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| Comparison of pathology and immune function of thymus in children with cyanotic and non-cyanotic congenital heart disease |
| GUO Chen1 AI Ling-yun2▲ HU Shu-xia1 YANG Wen-ping3 KE Jiang-wei4 MING Teng5 ZOU Yong5 |
1.Children′s Heart Center,Children′s Hospital of Jiangxi Province,Nanchang 330006,China;
2.Science and Education Section,Children′s Hospital of Jiangxi Province,Nanchang 330006,China;
3.Department of Pathology,Children′s Hospital of Jiangxi Province,Nanchang 330006,China;
4.Department of Pediatrics,Children′s Hospital of Jiangxi Province,Nanchang 330006;
5.Department of Cardiothoracic Surgery,Children′s Hospital of Jiangxi Province,Nanchang 330006,China |
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Abstract ObjectiveTo investigate the pathology and immune function of thymus in children with cyanotic and noncyanotic congenital heart disease,and to provide basis for the diagnosis and treatment of disease.Methods30 patients with cyanotic congenital heart disease(group A)and 40 patients with non-cyanotic congenital heart disease(group B)treated in our hospital from May 2016 to March 2017 were selected as subjects.The CD3,CD4,CD8,CD19,NK cells and cytotoxic T cells counts in two groups were detected and compared.The hist opathological changes of thymus in two groups were observed and compared.ResultsThe CD3,CD4,CD8,CD19,NK cells and cytotoxic T cells counts in group B were higher than those of group A,and the differences were significant(P＜0.05).The CD3,CD4,CD8,CD19,NK cells and cytotoxic T cells counts in children aged 1-2 years in both groups were lower than those of 0-1 years old children in the two groups,and the differences were significant(P＜0.05).Pathological examination resaults showed that both of the two groups had thymus structure exists,clear edge state,rich cortical lymphocytes,medullary thymus body structure exists,and no interstitial change,besides group B aged 1-2 years old children had small number of stars and thymus mild atrophy,group A aged 0-1 years old children had stars phenomenon and thymus mild atrophy,and group A aged 1-2 years old children had much stars and thymus atrophy.ConclusionThymic atrophy in children with cyanot-ic congenital heart disease are severe than that of the children with non-cyanotic congenital heart disease,and immune function in children with cyanotic congenital heart disease are lower than those of the children with non-cyanotic congenital heart disease.And the thymic atrophy and immune function lowering of children with congenital heart disease are aggravated with age.
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