曲美他嗪联合阿托伐他汀治疗冠心病同时降低血脂的效果研究

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Abstract ObjectiveTo explore the effect of Trimetazidine（TMZ） combined with Atorvastatin in the treatment of coronary heart disease and lower blood lipids.MethodsFrom September 2015 to October 2016,a total of 73 patients with hyperlipidemia and coronary heart disease who were treated in our hospital were selected and divided into observation group and control group by random grouping.The observation group were consisted of 37 patients and the control group of 36 cases.The control group was given oral TMZ on the basis of conventional therapy for two courses.The observation group was treated with oral TMZ combined with Atorvastatinfor two courses.After treatment,the clinical outcomes and adverse reactions were compared，meanwhile,the results of relevant indicators of serum lipid levels and serum creatinine,urea nitrogen and 24 h urine protein of two groups of patients before and after treatment were compared.ResultsAfter treatment，the total effective rate of clinical treatment of coronary heart disease in the observation group was higher than that in the control group,the incidence of adverse reactions was lower than that of the control group,the difference was statistically significant(P＜0.05);after treatment,the observation group of patients with lipid levels were lower than the control group,the difference was statistically significant(P＜0.05).Serum creatinine and urine nitrogen levels of two groups were compared,the difference was not statistically significant(P＞0.05),the level of 24 h urinary protein in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).ConclusionCompared with control group,observation group has a better clinical effect,the use of TMZ combined with Atorvastatin can lower blood lipids and get better results，it is recommended to promote the use of clinical.

Key words： Coronary heart disease Hyperlipidemia Trimetazidine Atorvastatin

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ZHANG Shu-xia. Effect of Trimetazidine combined with Atorvastatin on coronary heart disease and lower blood lipid[J]. 中国当代医药, 2017, 24(32): 133-135.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I32/133

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