大承气汤外敷结合常规方案治疗重症急性胰腺炎的临床效果

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Abstract ObjectiveTo study the clinical effect of Dachengqi Decoction as an external application combined with conventional therapy on severe acute pancreatitis(SAP)and its influence on serum C-reactive protein(CRP)and procalcitonin (PCT).MethodsFrom June 2010 to February 2016,60 SAP patients treated in Department of Gastroenterology in Hanchuan People′s Hospital were randomly divided into the control group(n＝30)and experimental group(n＝30).In the control group,conventional regimen was used,while in the experimental group,besides the conventional regimen,Dachengqi Decoction as an external application was added.The courses of treatment lasted 14 days in the two groups.The remission time of abdominal pain and distension,recovery time of bowel sound,time to defecate,and hospital stay and cost were recorded.The blood amylase (AMY),CRP,and PCT before and after treatment were tested.ResultsThe overall effective rate was 96.67%in the experimental group,which was higher than that in the control group (83.33%)(P＜0.05).In the experimental group,the remission time of abdominal pain and distension,recovery time of bowel sound,defecation time,time of blood routine,blood and urine AMY being normal were all shorter compared with those in the control group (P＜0.01).The hospital stay in the experimental group was shorter than the control group,and the hospitalization cost was lower in the experimental group (P＜0.01).The level of CRP and PCT and score of Ranson,APACHEⅡ,and CT in the experimental group were significantly lower than those in the control group (P＜0.01).ConclusionCombination of Dachengqi Decoction as an external application and conventional regimen can remarkably improve clinical symptoms including abdominal pain and distension,and intestinal paralysis,etc.at an acute stage in SAP patients,decrease the level of CPR and PCT,alleviate systemic damage due to inflammation of pancreas,and is beneficial to the rehabilitation of disease.

Key words： Severe acute pancreatitis Dachengqi Decoction External application C-reactive protein Procalcitonin

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	XIONG Xiao-yan
	TAN Shi-yun
	WANG Yong

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XIONG Xiao-yan,TAN Shi-yun,WANG Yong. Clinical effect of Dachengqi Decoction as an external application combined with conventional regimen in the treatment of severe acute pancreatitis[J]. 中国当代医药, 2017, 24(32): 152-155.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I32/152

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