中国当代医药
      Home                              中文
中国当代医药
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2018 Vol. 25, No. 2
Published: 2018-01-18
 
 
4 Effect of Scutellarin on angiokinesis responses in rats with spontaneous hypertension
CHEN Chen1LI Qing-qing2ZHANG Xiu-juan;DU Xiao-hua;DAI Ze-lan;RAO Qiang;DU Ting-yan;YANG Wei-min
ObjectiveTo investigate the effect of Scutellarin (SCU)on angiokinesis responses in rats with spontaneous hypertension(SHR).MethodsIn this study,basilar artery(BA)and coronary artery(CA)vascular rings which were isolated for 14 weeks and 40 weeks respectively from SHR and its control of Wistar-Kyoto rats(WKY)were applied.Wire Myograph vascular tension analysis system was applied,and tension changes of BA and CA vascular rings were measured.The effects of SCU on hypertension induced cardiovascular and cerebrovascular angiokinesis in rats were observed.ResultsIn the vasodilator reaction assay,the angiokinesis effect of blood vessels was significantly enhanced by incubation with SCU(P＜0.001),and 40 weeks vasodilation was stronger than that 14 weeks.In vasocontraction response assay,the maximum contraction rate of blood vessels was decreased with the increase of SCU incubation concentration,and the EC50value in the SCU group was significantly higher than that in the control group(P＜0.05).ConclusionScutellarin has certain influence on the vasodilatation and vasocontraction responses induced by hypertension in rats.
2018 Vol. 25 (2): 4-6转10 [Abstract] ( 161 ) HTML (29 KB)  PDF  (0 KB)  ( 62 )
7 In vitro anti-tumor activity of di-lacunary Keggin-type tungstate
LIN Xiao-qi;PENG Yue-si;XIA Meng-yu;CHEN Meng;GAO Ying-xue;XUE Ying-xue
ObjectiveTo study the in vitro anti-tumor activity of di-lacunary Keggin-type tungstate K8[γ-SiW10O36]·12H2O (abbreviated form：KSiW10).MethodsThe inhibitory effect of KSiW10 on the growth of human hepatoma HepG2 cells,lung cancer A549 cells and breast cancer MCF-7 cells was studied by MTT (3-[4,5-dimethylthiazo-2-y]-2,5-diphenyltetrazolium bromide)assay.The morphological change in HepG2,A549 and MCF-7 cells affected by different concentration of drugs was observed by optical microscopes.ResultsKSiW10could inhibit HepG2,A549 and MCF-7 cells proliferation,with IC50value of 9.8×10-5,3.6×10-4and 1.8×10-4mol/L,respectively,showing dose-dependent.The morphological changes in tumor cells showed shrinking of cells and round cells under an optical microscope after treating with different concentrations of KSiW10.ConclusionTungstate KSiW10has antitumor activity in vitro and can inhibit the proliferation of tumor cells.
2018 Vol. 25 (2): 7-10 [Abstract] ( 160 ) HTML (34 KB)  PDF  (0 KB)  ( 71 )
11 Influence of Emodin on the expression of iNOS,COX-2 in hippocampus after status epilepticus by kainic acid in mice
OUYANG Long-qiang; XIA Wen-yan;YANG Shao-chun; ZOU Lian-sheng ;LOU Jian-yun; GAO Zhi-qiang
ObjectiveTo investigate Emodin′s influence on the expression of iNOS,COX-2 in hippocampus of mice after status epilepticus by kainic acid.Methods45 ICR male mice were selected and randomly divided into the control group,the SE group and the Emodin group,15 cases in each group.The epileptic model of mice was established by kainic acid.The treatment group was injected with 200 mg/kg by Emodin.The SE group and the control group were injected an equal amount of saline.HE stain was observed the morphological changes in hippocampal nerve after 24 h,RT-PCR and Western blot was used to detect the expression of the mRNA and protein level of iNOS,COX-2.ResultsEmodin could significantly relieve the hippocampal injury after status epilepticus in mice.The content of iNOS,COX-2 mRNA and protein in the Emodin group was significantly lower than that of the mRNA and protein in the SE group,with significant difference(P＜0.05).ConclusionEmodin may derease the expressions of the mRNA and protein 1evel of iNOS,COX-2 in hippocampus after status epilepticus in mice.
2018 Vol. 25 (2): 11-14 [Abstract] ( 147 ) HTML (30 KB)  PDF  (0 KB)  ( 61 )
15 Related research progress in influence of airborne particulate matter on micro-ecology of respiratory tract
LI Bing-yu; XIAO Chun-ling
With the development of society and the progress of industrial technology,air pollution has become a global social problem.The airborne particulate matter adsorbing a variety of harmful substances and pathogens can enter the airway and deposit in the alveolar cavity,change the micro-ecology of respiratory tract,cause inflammation,and adversely affect the health of the body.This paper discusses in detail the main characteristics and sources of airborne particulate matter which has adverse effects on human body,the balance and imbalance of micro-ecology of the respiratory tract,the influence of airborne particulate matter on the micro-ecology of the respiratory tract,and the application of probiotics.
2018 Vol. 25 (2): 15-18 [Abstract] ( 169 ) HTML (34 KB)  PDF  (0 KB)  ( 82 )
19 Study of the therapeutic mechanism of chronic subdural hematoma by hormone
CHEN Xu;ZHAN Jian;ZHANG Yong-an;GONG Shao-hui
ObjectiveTo investigate the therapeutic mechanism of hormone on chronic subdural hematoma.MethodsFrom August 2015 to December 2016,53 patients with chronic subdural hematoma admitted to our hospital were selected as subjects and randomly divided into control group and experimental group.In the control group (n=26),treatment including borehole drainage,intraoperative rinse and postoperative intensive fluid replacement was used,while in the experimental group (n=27),hormone was applied on the basis of borehole drainage.The therapeutic effect,recurrence rate,incidence of re-bleeding after clot lysis,postoperative quality of life score and hospital stay in the two groups were compared.ResultsThe total effective of the two groups was compared,and the difference was not statistically significant(P＞0.05).After treatment,the recurrence rate(7.41%)and incidence of re-bleeding after clot lysis(18.52%)of patients in the experimental group were lower than those in the control group(23.36%,27.63%),and the differences were statistically significant(P＜0.05).The postoperative quality of life score of patients in the experimental group was higher than that of the control group,the hospitalization time was shorter than that in the control group,and the differences were statistically significant(P＜0.05).ConclusionAccording to the results,implementation of borehole drainage for the patients with chronic subdural hematoma have less postoperative complications,but with plenty of recurrent manifestations which are not helpful in patients′prognosis.Application of hormone therapy can significantly reduce the recurrence rate and promote the prognosis of patients.
2018 Vol. 25 (2): 19-21 [Abstract] ( 166 ) HTML (25 KB)  PDF  (0 KB)  ( 77 )
22 Clinical comparative analysis of positive and negative HIV antibody cryptococcal meningitis
TIAN Xiao-li;WU Song-lin
ObjectiveTo analyze the clinical characteristics of cryptococcal meningitis patients with positive and negative HIV antibody.MethodsThe clinical data of 53 patients with cryptococcal meningitis treated in our hospital from June 2014 to June 2017 were retrospectively analyzed.The patients were divided into two groups according to the positive and negative HIV antibody,HIV antibody positive group had 27 cases and HIV antibody negative group had 26 cases.The clinical manifestations,laboratory tests and death rate of the two groups were compared.ResultsThe gender and preclinical course of HIV antibody positive group and HIV antibody negative group were compared,the differences were not statistically significant(P＞0.05).Headache and vomiting were the main clinical manifestations in the two groups.The cerebrospinal fluid protein,cerebrospinal fluid cell count,cerebrospinal fluid saccharide,cerebrospinal fluid LDH,cerebrospinal fluid chloride,blood chlorine and other indicators were compared in the two groups,and the differences were not statistically significant(P＞0.05).The blood lymphocyte count of patients in the HIV antibody positive group was lower than those of the HIV antibody negative group,and the difference was statistically significant(P＜0.05).The death rate was compared between the two groups,and the difference was not statistically significant(P＞0.05).In patients with preclinical course of less than 10 d,the death rate of patients in the HIV antibody positive group was lower than those of the HIV antibody negative group,and the difference was statistically significant(P＜0.05).ConclusionThe preclinical course of cryptococcal meningitis in HIV antibody positive patients is shorter than that of HIV antibody negative group,but there is no significant difference between two groups in cerebrospinal fluid examination and clinical prognosis,which indicates that the disease progression of HIV-positive patients is faster.
2018 Vol. 25 (2): 22-24转28 [Abstract] ( 154 ) HTML (27 KB)  PDF  (0 KB)  ( 49 )
25 The experience of bronchoalveolar lavage with bronchoscope in the treatment of pneumonia caused by extensively drug-resistant Acinetobacter and the changes of serum IL-6 and PCT
DENG Zhi-qiang;FENG Xue-ying;HUAN Jian
ObjectiveTo investigate the value of bronchoalveolar lavage (BAL)in the treatment of extensively resistant Acinetobacter pneumonia and the changes of serum IL-6 and PCT.MethodsThe 50 patients with pneumonia treated in our hospital from January 2014 to June 2017 were selected and randomly divided into group A and group B according to CPIS scores,PCT values and stratified randomized grouping method,25 patients in each group.The patients in group A were treated with 1 g of Meropenem and 3 g of Piperacillin and Sulbactam,each 8 h intravenous drip was injected 1 time,the patients were treated for 2 consecutive weeks.The patients in group B were given electronic endotracheal tube lavage on the basis of antibiotic treatment of group A,daily or alternate days(depending on the amount of sputum and tolerance of the patient).The clinical pulmonary infection score,oxygenation index,serum IL-6 and PCT level of the two groups were compared before and after treatment for 1 or 2 weeks.ResultsAfter 1 week of treatment,the indicators of group A were compared with those before treatment,and the differences were not statistically significant(P＞0.05).The serum IL-6 and PCT of patients in group B were lower than before treatment,and the differences were statistically significant(P＜0.05),but CPIS score was compared with that before treatment,the difference was not statistically significant(P＞0.05).After 1 week of treatment,patients of group B with serum IL-6 and PCT were lower than those in group A,the PaO2/FiO2was significantly higher than that of group A,the differences were statistically significant(P＜0.05),while the CPIS score of patients in group B was compared with group A,the difference was not statistically significant(P＞0.05).After 2 weeks of treatment,the serum IL-6 and PCT of patients in group A were lower than before the treatment,the PaO2/FiO2was higher than before the treatment,and the differences were statistically significant(P＜0.05),but the CPIS score was compared with before treatment,the difference was not statistically significant(P＞0.05).The serum IL-6,PCT and CPIS score in group B were lower than before treatment,while PaO2/FiO2was higher than before the treatment,and the differences were statistically significant(P＜0.05).After 2 weeks of treatment,the serum IL-6,PCT and CPIS score in group B were significantly lower than those in group A,while the PaO2/FiO2was significantly higher than group A,and the differences were statistically significant(P＜0.05).ConclusionFor patients with lung infection caused by extensively drug-resistant Acinetobacter,bronchoalveolar lavage can rapidly decrease the serum levels of IL-6 and PCT,improve oxygenation and relieve the clinical symptoms.
2018 Vol. 25 (2): 25-28 [Abstract] ( 145 ) HTML (29 KB)  PDF  (0 KB)  ( 82 )
29 Effect of microwave combined with Interleukin-2 and Interferon Vaginal Effervescent Tablets in the treatment of female condyloma acuminatum
CHEN Hui-qin
ObjectiveTo investigate the curative effect of microwave combined with Interleukin-2(IL-2)and Interferon Vaginal Effervescent Tablets in the treatment of female condyloma acuminatum.MethodsAltogether 120 cases of condyloma acuminatum who were treated in outpatient of our hospital from January 2016 to June 2017 were selected as the subjects of this research and randomly divided into the experiment group and the conventional group according to the random number method,60 cases in each group.The conventional group was treated with single microwave,and the experiment group was treated with Interleukin-2 and Interferon Vaginal Effervescent Tablets on the basis of the conventional group.The curative effect and the incidence of adverse reactions were compared between the two groups.ResultsThe total effective rate in the experimental group(90.00%)was significantly higher than the conventional group(66.67%),and the difference was statistically significant(P＜0.05).In the experimental group,1 patient showed slight pain and discomfort in the waist and abdomen after treatment,but the symptoms gradually disappeared without any treatment in a few days later.ConclusionApplication of microwave combined with Interleukin-2 and Interferon Vagina Effervescent Tablets is effective in the treatment of female condyloma acuminatum,with low recurrence rate,which is worthy of clinical promotion.
2018 Vol. 25 (2): 29-31 [Abstract] ( 167 ) HTML (27 KB)  PDF  (0 KB)  ( 39 )
32 Effect of Shenmai Injection on blood pressure and heart rate in carotid artery stenting
MO Jian-yi
ObjectiveTo investigate the effect of Shenmai Infection on blood pressure and heart rate in carotid artery stenting.Methods60 cases of patients with carotid artery stenosis treated in our hospital from April 2015 to June 2016 were selected as subjects.These patients were divided into trial group and control group randomly,30 cases in each group.Patients in control group received routine treatment,the patients in trial group were treated with Shenmai Injection 3 hours    before the surgery until 7 days later.Thesystolicbloodpressure,diastolicbloodpressureandheartrateofbeforetheintervention,1 h after the anaesthesia,24 h and 72 h after the surgery were compared between the two groups.ResultsBefore intervention,the systolic blood pressure,diastolic blood pressure and heart rate of the two groups were comapred,and the differences were not statistically significant(P＞0.05).The systolic blood pressure,diastolic blood pressure and heart rate of 1 h after the anaesthesia,24 h and 72 h after the surgery of the two groups were higher than those of before intervention,the systolic blood pressure,diastolic blood pressure and heart rate of 1 h after the anaesthesia,24 h and 72 h after the surgery of patients in the trial group were higher than those in the control group,and the differences were statistically significant(P＜0.05).ConclusionShenmai Infection could help maintain the systolic blood pressure,diastolic blood pressure and heart rate stable,which is effective and safety and to be worth spreading and further research.
2018 Vol. 25 (2): 32-34 [Abstract] ( 167 ) HTML (25 KB)  PDF  (0 KB)  ( 70 )
35 Effect of bronchofibroscopic bronchoalveolar lavage on inflammatory factor and lung function in patients with severe pneumonia
YE Xian-qin;XU Wei-zhen;MO Jian-wei;LIU Bin;WU Chun-yan
ObjectiveTo investigate the effect of bronchofibroscopic bronchoalveolar lavage on inflammatory factor and lung function in patients with severe pneumonia.Methods80 patients with severe pneumonia treated in our hospital from February 2015 to December 2016 were selected as subjects,and they were divided into two groups by random number table method,40 cases in each group.Control group was given conventional treatment,while observation group was given bronchofibroscopic bronchoalveolar lavage based on control group.The inflammatory factors and lung function factors were compared between the two groups.ResultsBefore treatment,the STREM-1,HMGB-1,CD11b positive neutrophils,FVC,FEV1and FVC/FEV1were compared of patients between the two groups,and the differences were not statistically significant(P＞0.05).After treatment,the STREM-1,HMGB-1,CD11b positive neutrophils,FVC,FEV1and FVC/FEV1of patients in the two groups were significantly lower than before treatment,the STREM-1,HMGB-1 and CD11b positive neutrophils of patients in the observation group were lower than those in the control group,while the FVC,FEV1and FVC/FEV1in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).ConclusionBronchofibroscopic bronchoalveolar lavage for patients with severe pneumonia is effective,it can improve lung function and reduce inflammatory response.
2018 Vol. 25 (2): 35-37 [Abstract] ( 162 ) HTML (26 KB)  PDF  (0 KB)  ( 67 )
38 Effect analysis of Magnesium Isoglycyrrhizinate on patients with hemorrhagic fever with renal syndrome
LIU Dan
ObjectiveTo investigate the effect of Magnesium Isoglycyrrhizinate on patients with hemorrhagic fever with renal syndrome.MethodsA total of 60 patients with hemorrhagic fever with renal syndrome treated in our hospital from June 2015 to April 2017 were selected as subjects of this study.The patients were divided into observation group and control group by random assignment method,30 cases in each group.The control group was treated with routine treatment.The patients in the observation group were treated with Magnesium Isoglycyrrhizinate on the basis of the treatment of the control group.The clinical efficacy in the treatment of more than half,the change of alanine aminotransferase(ALT)aspartate amino acid transferase(AST)in the serum before and after treatment and the average treatment time of the two groups of patients were compared.ResultsIn the treatment of more than half,the therapeutic efficiency of the observation group(96.67%)was significantly higher than that in the control group(73.33%),and the difference was statistically significant(P＜0.05).Before treatment,the levels of ALT and AST in the two groups were compared,and the differences were not statistically significant(P＞0.05).After treatment,the levels of ALT and AST in the observation group was significantly lower than those in the control group,and the average treatment time was shorter than that in the control group,the differences were statistically significant(P＜0.05).ConclusionThe treatment of patients with hemorrhagic fever with renal syndrome is based on the general treatment.The treatment of Magnesium Isoglycyrrhizinate can improve the total effective rate of the treatment,improve the liver function and improve the rehabilitation rate,and be worthy of clinical application.
2018 Vol. 25 (2): 38-40 [Abstract] ( 132 ) HTML (25 KB)  PDF  (0 KB)  ( 78 )
41 Clinical significance of fractional exhaled Nitric Oxide test in asthmatic patients at different stages
CHEN Lin
ObjectiveTo investigate the clinical significance of fractional exhaled Nitric Oxide(FeNO)test in asthmatic patients at different stages.Methods30 patients with asthma treated in our hospital from June to December 2016 were selected as asthma group of this study,and 30 non smokers in our hospital during the same period were selected as the control group.The FeNO values were compared between the two groups before treatment(T1),at 4 weeks(T2)and 12 weeks(T3)of treatment.ResultsAt T1,T2and T3,the FeNO values of patients in the asthma group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).At T2,the FeNO value of patients in the asthma group was lower than T1,and the difference was statistically significant(P＜0.05).At T3,the FeNO value of patients in the asthma group was significantly lower than that of T1and T2,and the differences were statistically significant(P＜0.05).ConclusionThe FeNO value of patients in the asthma group at different stages are higher than those of healthy people,and with the increase of treatment time,the detection value of FeNO gradually decreased,and the FeNO test has a good guiding role in the treatment of asthma.
2018 Vol. 25 (2): 41-43 [Abstract] ( 152 ) HTML (27 KB)  PDF  (0 KB)  ( 71 )
44 Effect observation of Tiotropium combined non-invasive ventilation on chronic obstructive pulmonary disease and pulmonary function in patients with typeⅡrespiratory failure
YIN Ying-qiu;ZHENG Hui-ying;WEI Jie;YANG Yin-lou
ObjectiveTo investigate the effect of Tiotropium combined with non-invasive ventilation on chronic obstructive pulmonary disease and pulmonary function in patients with typeⅡrespiratory failure.Methods108 cases of COPD and typeⅡrespiratory failure patients treated in our hospital from February 2014 to December 2016 were selected as subjects and were divided into the control group and the study group according to the random number method,54 cases in each group.The patients in the control group were treated with non-invasive ventilation,and patients in the study group were treated with Tiotropium combined with non-invasive ventilation.The dyspnea symptom scores,lung function indexs,blood gas correlation indexs and 6 min walking distance were compared between the two groups.ResultsAfter the intervention,the score of dyspnea symptoms in the study group was significantly lower than those in the control group,the difference was statistically significant(P＜0.05).The PaO2of the study group was significantly higher than that of the control group,and the PaCO2of the study group was lower than that of the control group,the differences were statistically significant(P＜0.05).The FEV1,FVC and FEV1/FVC in the study group were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).The walking distance of 6 min in the study group was significantly long than that in the control group,the difference was statistically significant(P＜0.05).ConclusionTiotropium combined with noninvasive ventilation in the treatment of COPD patients with typeⅡrespiratory failure can significantly improve the pulmonary function and blood gas index,reducing dyspnea score,improve exercise tolerance,and be worth promoting the application.
2018 Vol. 25 (2): 44-46转49 [Abstract] ( 173 ) HTML (31 KB)  PDF  (0 KB)  ( 75 )
47 Clinical effect comparison of laparoscopic and open radical gastrectomy treating advanced gastric cancer
WU Chang-hua
ObjectiveTo explore the clinical effect of laparoscopic and open radical gastrectomy treating advanced gastric cancer.MethodsFrom December 22,2015 and April 26,2017,64 patients with advanced gastric cancer admitted into our hospital were selected and divided into the study group and control group according to lottery method,and there were 32 patients in each group.The study group was given laparoscopic radical gastrectomy,while the control group was given radical gastrectomy.The operation time,intraoperative blood loss,incision length,postoperative recovery time,bed ambulation time,and the incidence of incisional infection and residual gastric inactivity were compared between the two groups.ResultsThe operation time,incision length,postoperative recovery time,bed ambulation time in the study group were shorter than those of the control group(P＜0.05).The incidence of incisional infection and residual gastric inactivity in the study group were lower than those of the control group(P＜0.05).ConclusionLaparoscopic radical gastrectomy for patients with advanced gastric cancer has a significant effect.
2018 Vol. 25 (2): 47-49 [Abstract] ( 178 ) HTML (23 KB)  PDF  (0 KB)  ( 65 )
50 Comprehensive clinical efficacy comparison of thoracoscopic assisted and open radical resection of esophageal carcinoma
CHANG Hui-wen;ZHANG Ya-jun;SONG Jian-xiang;SHI Zhan
ObjectiveTo compre the comprehensive clinical efficacy of thoracoscopic assisted and open radical resection of esophageal carcinoma.MethodsFrom May 2014 to May 2017,62 patients with esophageal cancer diagnosed and treated in our hospital were selected as object,and they were divided into the study group (n=31)and reference group(n=31)according to the random number table method.The patients in the reference group were treated with traditional open radical resection of esophageal cancer,and the patients in the study group were treated with thoracoscopic assisted radical resection of esophageal carcinoma.The operation time,the length of stay,the number of lymph node dissection and the amount of bleeding during operation,the drainage volume of after 24 h operation,the degree of chest pain after 36 h operation,and the incidence of postoperative complications were compared between the two groups.ResultsThere was no significant difference of the operation time and the number of lymph node dissection in patients between the two groups (P＞0.05).The length of stay in patients of the study group was significantly shorter than that in the reference group,the amount of bleeding during operation,the drainage volume of after 24 h operation in patients of the study group were significantly fewer than those of the control group,the chest pain score after 36 h operation in patients of the study group was significantly lower than that in the reference group,and there was a statistical difference(P＜0.05).Conclusionthoracoscopic assisted and open radical resection of esophageal carcinoma has a characteristics of small trauma,few bleeding amount,faster postoperative recovery,and can effectively reduce the incidence of postoperative complications,compared with open radical operation of esophageal cancer,the advantages are more obvious,and it is worthy of widely promotion and application in clinic.
2018 Vol. 25 (2): 50-52 [Abstract] ( 161 ) HTML (25 KB)  PDF  (0 KB)  ( 71 )
53 Effect comparision of laparoscope and laparotomy treating uterine fibroid and its influence on immune function
MI Yi
ObjectiveTo investigate the effect of laparoscope and laparotomy treating uterine fibroid and its influence on immune function.Methods124 patients with uterine fibroid treated in department of gynaecology of our hospital from February 2015 to August 2016 were extracted as object.The patients were grouped by operation method:the control group(n=62)was treated with laparotomy,while the experimental group(n=62)was treated with laparoscopic myomectomy.The treatment effect between the two groups was compared and the change of immune function was compared.ResultsThe bleeding amount during operation in the experimental group was significantly fewer than that in the control group,and the postoperative ambulation time,the recovery time of gastrointestinal function and the hospitalization time in the experimental group were significantly shorter than those in the control group(P＜0.05).The level of immune index in the experimental group was significantly higher than that in the control group after operation (P＜0.05).The total incidence of complications and recurrence rate in the experimental group were significantly lower than those in the control group(P＜0.05).ConclusionCompared with laparotomy,laparoscopic surgery has better short-term and long-term effect in the treatment of uterine fibroids,and has little influence on immune function and fewer complications.It is worthy of reference.
2018 Vol. 25 (2): 53-55 [Abstract] ( 181 ) HTML (27 KB)  PDF  (0 KB)  ( 82 )
56 Clinical effect observation of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer
SHI Hong-wei;XU Bin ;LIN Bin
ObjectiveTo investigate the clinical effect of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer.MethodsFrom November 7,2015 to December 3,2016,82 patients with primary liver cancer were selected and they were randomly divided into two groups.The control group was treated with transcatheter arterial chemoembolization.On this basis,the observation group was treated with Bazhen Decoction and Huaji Pills.The clinical effect,quality of life and the incidence of adverse events were observed in the two groups.ResultsThe total remission rate of the observation group was 51.22%,which was significantly higher than that of the control group(24.39%)(P＜0.05).Psychological,physiological function,social relationship,material life score in the observation group was(81.55±3.03),(84.86±3.57),(80.89±4.14),(86.27±3.06)points respectively,which was higher than that of the control group ([76.19±3.26],[72.71±2.79],[71.79±3.28],[75.79±4.11]points)(P＜0.05).There was no significant difference in the incidence of adverse events between the two groups(P＞0.05).ConclusionThe clinical value of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer is high.
2018 Vol. 25 (2): 56-58 [Abstract] ( 179 ) HTML (25 KB)  PDF  (0 KB)  ( 46 )
59 Effect comparison of laparoscopic radical resection of colon cancer and laparotomy treating colon cancer
CHEN Xin-gui;XIE Rong-ming; WEI Wen-bo ;JIANG Shu-song
ObjectiveTo explore the effect of laparoscopic radical resection of colon cancer and laparotomy treating colon cancer.Methods100 patients with colon cancer treated in our hospital from June 2015 to June 2017 were divided into the control group(n=50)and the study group(n=50)by blind selection method.The control group was treated with laparotomy,while the study group was treated with laparoscopic radical resection of colon cancer.Clinical effect between the two groups was compared.ResultsThe operation time,lymph nodes were compared between the two groups had no difference (P＞0.05).The intraoperative blood loss in the study group was significantly fewer than that in the control group,postoperative exhaust time,hospitalization time and gastrointestinal function recovery time in the study group were significantly shorter than those in the control group (P＜0.05).The incidence of postoperative complications in the study group was significantly lower than that in the control group(P＜0.05).ConclusionThe clinical effect of laparoscopic radical resection of colon cancer is more significant than that of laparotomy,and it is worthy of clinical promotion and application.
2018 Vol. 25 (2): 59-61 [Abstract] ( 193 ) HTML (24 KB)  PDF  (0 KB)  ( 72 )
62 effect analysis of neural behavior detection in premature infants and early intervention in child healthcare clinic
CHEN Kui-huan
ObjectiveTo investigate clinical effect analysis of the neural behavior detection in premature infants and early intervention in child healthcare clinic.MethodsFrom March 2015 to March 2017,235 preterm infants born in our hospital were selected as research objects.According to the neurobehavioral evaluation and differences of intervention methods,they were divided into observation group(n=110)and control group(n=125).In the observation group,premature infants were provided with neurobehavioral evaluation 3 months after month corrections.If the score less than 37 points,infants were required to be hospitalized and performed with intervention measures such as exercise therapy,physical therapy,and nerve electrical stimulation.If the score no less than 37 points,personalized training at home was necessary after instructing parents.The training was adjusted reasonably according to the actual state of neurological assessment.After 3 month intervention,the development of neural behavior was assessed.In the control group,neurobehavioral screening and status of development assessment were directly performed 3 months after month corrections.The clinical intervention effect on neurobehavioral screening was compared in the two groups.ResultsIn the observation group,the detection rate of nervous abnormality was significantly lower than that in the control group with a statistical difference(P＜0.05).With regard to development assessment of the functional areas,the large movement,adaptive capacity,and development quotient were significantly better than those in the control group,which were displayed statistical significance(P＜0.05).ConclusionThe implementation of neurobehavioral detection in premature infants has advantages of strong safety and simple operation.Early detection and intervention on neural deviation in premature infants can reduce the incidence of their nerve abnormalities,and improve the motor development as well as intelligence level of premature infants.
2018 Vol. 25 (2): 62-64 [Abstract] ( 181 ) HTML (26 KB)  PDF  (0 KB)  ( 57 )
65 Bacterial vaginosis in patients with high-risk HPV infection and local microcirculation changes in the situation
ZHOU Bo;HE Yun ;WEI Yu; DING De-xian
ObjectiveTo investigate the changes of high-risk HPV infection and local microcirculation in patients with bacterial vaginal diseases,and to provide a reliable basis for the treatment of the disease.MethodsFrom July 2016 to June 2017 in our hospital was diagnosed with bacterial vaginosis in 350 patients as the experimental group,select the same period of 350 cases of healthy women as the reference group.The HPV infection and local microcirculation were observed and compared between the two groups.ResultsThe HPV16，HPV18 and other high-risk HPV infection rates were 31.14%,34.86%and 32.29%in the experimental group,which were significantly higher than those in the reference group（6.86%,7.71%and 5.43%,respectively）.The differences were statistically significant(P＜0.05).The severe infection rate of HPV16,HPV18 and other high-risk HPVs in the experimental group was significantly higher than the moderate infection rate,and the moderate infection rate was significantly higher than the mild infection rate,the difference was statistically significant(P＜0.05).The composition of the cervix in the experimental group was significantly higher than that in the reference group,and the color was light red,that is,the microcirculation normal state was lower than the reference group(P＜0.05).In the experimental group,the prevalence of cyanosis,dark red and redness of cervix was significantly higher than that of moderate constitution,and the ratio of moderate constitution was significantly higher than that of mild constitution both were statistically significant(P＜0.05).The diameter of capillary tube,blood perfusion and microvessel diameter of the experimental group were significantly lower than those of the control group(P＜0.05).In the experimental group,the microvascular diameter,the capillary diameter and the severity of blood flow instillation were mildly higher than moderate and moderately higher than those in severe group(P＜0.05).ConclusionBacterial vaginosis patients with high-risk HPV infection rate was significantly higher than healthy women,local microcirculation changes were significantly worse than healthy women,indicators for the degree of the patient′s disease has a certain significance,clinical aspects should be increased attention and intervention.
2018 Vol. 25 (2): 65-67 [Abstract] ( 163 ) HTML (28 KB)  PDF  (0 KB)  ( 41 )
68 Analysis of related factors of autism in children
XIAO Qiu-yan;WANG Wei
ObjectiveTo investigate the incidence of autism among community children and related factors.MethodsFrom June 2016 to June 2017,453 infants aged from 18 to 24 months in the community were selected as the subjects.Autism screening was conducted by using the infant communication and symbolic behavior development scale (CSBSDP).Univariate and multivariate logistic regression were used to analyze the influencing factors of autistic screening for children with autism.ResultsSocial interaction,language features and symbolic behavior of suspicious rate is 2.65%,5.96%and 3.97%respectively,total score suspicious for 21 cases,positive rate was 4.64%.Univariate logistic regression analysis showed that there were statistically significant differences in gender,gestational age,anemia,parental relationship,educational style and parental education(χ2=8.34,28.66,10.50,22.92,48.83,51.20,6.53,5.98,P＜0.05).Multivariate logistic regression analysis showed that boys,anxiety/depression during pregnancy,premature birth and anemia were risk factors for autism in children(OR=1.869,1.569,1.457,1.682),and harmonious in parental relationship,persuasion education and parental education were the protective factors of autism(OR=0.547,0.422,0.532,0.557).ConclusionThere is a certain proportion of autistic people in the 18-24 months population,and are affected by a variety of factors.
2018 Vol. 25 (2): 68-70 [Abstract] ( 190 ) HTML (23 KB)  PDF  (0 KB)  ( 72 )
71 Clinical effect of high-dose Cyclophosphamide in the treatment of nephrotic syndrome children with Henoch Schonlein purpura nephritis
ZOU Xian;LI Jian-wei
ObjectiveTo investigate the effect of high dose Cyclophosphamide combined with prednisone in children with nephrotic syndrome and purpura nephritis.Methods60 cases of nephrotic syndrome type purpura nephritis were selected from February 2014 to March 2016.According to the random number table method,the control group and the study group were divided into 30 cases.The control group was treated with strong pine treatment,the study group to give high-dose Cyclophosphamide combined with prednisone treatment.Compared of the clinical efficacy of the two groups,24 h urinary protein,peripheral white blood cell(WBC)count,urine red blood cell count,total cholesterol(TC），triglyceride（TG）,serum creatinine(Scr),blood urea nitrogen(BUN),plasma albumin(ABL),extra renal symptoms and adverse reaction should the occurrence.ResultsThe total remission rate of the study group(93.33%)was significantly higher than that of the control group(66.66%)(P＜0.05).After intervention,the levels of 24 h urinary protein,TG,Scr,BUN,TC,and urine red blood cell count in the study group were significantly different from those in the control group(P＜0.05).After the intervention,the proportion of Cushing syndrome in the study group was significantly less than that in the control group(P＜0.05),and the proportion of microscopic hematuria was significantly smaller than that of the control group(P＜0.05).ConclusionHigh dose Cyclophosphamide combined with prednisone in the treatment of children with nephrotic syndrome type purpura nephritis curative effect is exact,less adverse reactions in patients,can significantly improve renal function.
2018 Vol. 25 (2): 71-73 [Abstract] ( 174 ) HTML (26 KB)  PDF  (0 KB)  ( 66 )
74 Interferon suppository with cervical electric loop possibility cutting treatment of cervical human papilloma virus infection
LIU Jin-lan
ObjectiveTo investigate the interferon suppository combined with loop electrosurgical excision procedure(LEEP)for the treatment of cervical human papilloma virus(HPV)infection in the clinical effect.Methods100 cases of cervical infection with high-risk HPV infection were treated in our hospital from February 2014 to December 2016,and LEEP operation was performed.The patients were divided into control group and study group according to the patients′wishes,50 cases in each group.The control group was treated with LEEP surgery,and the study group was treated with interferon suppository combined with LEEP treatment.The clinical efficacy,HPV negative condition,TCM syndrome score,clinical symptom and physical sign score,wound healing time and adverse reactions were compared between the two groups.ResultsThe clinical effective rate of the study group(94.00%)was higher than that of the control group(80.00%)(P＜0.05).The negative rate of HPV in the study group(86.00%)was higher than that in the control group(64.00%)(P＜0.05).Before the intervention，two groups of TCM syndrome score and clinical symptom score was not statistically significant(P＞0.05),after the intervention of the two groups of TCM syndrome score and clinical symptom score were decreased (P＜0.05),and the study group was lower than the control group (P＜0.05).The wound healing time of the study group was shorter than that of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the adverse reactions between the two groups(P＞0.05).ConclusionInterferon suppository combined with LEEP in the treatment of cervical HPV infection can significantly improve the clinical symptoms of patients,the curative effect is exact,and has a certain security.
2018 Vol. 25 (2): 74-76 [Abstract] ( 145 ) HTML (25 KB)  PDF  (0 KB)  ( 76 )
77 Comparison of the effect of cervical cold knife conization and cervical resection for cervical intraepithelial neoplasia
ZHENG Man-jia
ObjectiveTo explore contrast cervical cold knife cuts（CKC） and the cervical cone annular cutting （LEEP）treatment of cervical intraepithelial neoplasia（CIN）Ⅲ level effect.Methods82 CINⅢ patients who treated in our hospital from April 2014 to July 2015 were selected for this study.They were divided into two groups according to the random number table method,41 cases in each group.One group patients were treated with CKC,referred to as CKC group.The other were treated with LEEP,referred to as LEEP group.The clinical data of the two groups were observed and recorded.ResultsThe operation time,intraoperative blood loss and postoperative cervical healing time of the two groups of patients was compared,LEEP group were lower than the CKC group,the difference between the two groups was statistically significant(P＜0.05).The recurrence of the two groups of patients at 3,6,12 and 22 months after surgery was compared,CKC group was lower than LEEP group，the difference between the two was statistically significant(P＜0.05).HPV infection between the two groups of patients was compared,patients in the CKC group were significantly lower than those in the LEEP group,the difference was statistically significant(P＜0.05).ConclusionTraditional CKC and LEEP surgery have their own characteristics.The advantages of LEEP is quick and easy operation.Its trauma is small and patients′recovery time is short.But there is also disadvantage,like small range of cutting and cutting edge relapsing easily.Therefore for the treatment of patients with cervical intraepithelial neoplasia,the decision should be made according to their concrete condition and need.
2018 Vol. 25 (2): 77-79 [Abstract] ( 137 ) HTML (23 KB)  PDF  (0 KB)  ( 67 )
80 Clinical effect of Sodium Phosphate creatine for the treatment of asphyxia neonatal myocardial injury
SHAO Xiao-hui
ObjectiveTo observe the clinical effect of Sodium Phosphate creatine in the treatment of asphyxia neonatal myocardial injury.MethodsFrom February 2016 to January 2017,100 with myocardial damage in neonatal asphyxia patients received treatment in our hospital were selected as the research objects.All patients were divided into observation group and control group according to the different treatment methods,50 cases in each group.The patients in control group were given the conventional treatment method,the patients in observation group were given Sodium Phosphate creatine treatment.The with troponin I and troponin T index,myocardial enzyme index and the incidence of adverse reaction of patients in the two groups were evaluated.ResultsThe total effective rate was(98.00%)and the improvement of ECG in the observation group were higher than that of the control group(P＜0.05).The CK[(453.37±1.03)U/L],CK-MB[(6.65±1.02)U/L],HBDH[(62.98±1.02)U/L],LDH[(435.03±1.65)U/L],the incidence of adverse reactions,troponin I and troponin T in the the observation group were lower than that of the control group,the differences were statistically significant(P＜0.05).ConclusionSodium Phosphate used in the treatment of asphyxia neonatal myocardial injury has a significant clinical effect and high safety,which can effectively improve the myocardial enzyme index and is worthy of study.
2018 Vol. 25 (2): 80-82 [Abstract] ( 151 ) HTML (26 KB)  PDF  (0 KB)  ( 77 )
83 Clinical observation and safety evaluation of laparoscopic cystectomy for ovarian cysts
HE Hong-xing
ObjectiveTo investigate the efficacy and safety of laparoscopic cystectomy for ovarian cysts.MethodsA total of 60 patients with benign ovarian tumors treated in our hospital from June 2006 to June 2013 were enrolled.Acording to the order of admission,they were divided into routine group(n=30)and experimental group(n=30).Laparotomy was used in the routine group,while laparoscopic surgery was adopted in the experimental group.The surgical therapeutic effect,ovarian function,incidence of adverse reaction were compared between the two groups.ResultsThe operation time,recovery of intestinal function,and hospital stay in the experimental group were shorter than those in the routine group.The amount of bleeding was less compared with the routine group.The highest body temperature 24 hours after operation was lower than that of the routine group with a statistical difference(P＜0.05).After surgery,the level of E2was higher,LH and FSH levels were lower,the number of antral follicles was less compared with the routine group,which were displayed statistical differences(P＜0.05).The incidence of adverse reaction in the experimental group was significantly lower in comparison of that in the routine group with statistical significance.ConclusionFor patients with benign ovarian cysts,application of laparoscopic ovarian cystectomy can obtain a remarkable effect and is beneficial to the early recovery of the body,which is worthy of promotion and clinical practice.
2018 Vol. 25 (2): 83-85 [Abstract] ( 148 ) HTML (24 KB)  PDF  (0 KB)  ( 77 )
86 Clinical effect of drug in combination as an adjuvant therapy in children with severe pneumonia
LIANG Rui-tian
ObjectiveTo explore the clinical effect of drug in combination as an adjuvant therapy in children with severe pneumonia.MethodsFrom April 2015 to April 2017,the clinical data of 80 children with severe pneumonia in our hospital were statistically analyzed.According to the different therapeutic methods,these childrens were evenly divided into routine treatment group and routine treatment combined with Dopamine and Phentolamine group(adjuvant therapy group).The clinical efficacy,duration of main clinical manifestations,hospital stay,and incidence of adverse reactions were statistically analyzed.ResultsIn the adjuvant therapy group,the total effectiveness rate was 95.0%,which was greatly higher than that in routine treatment group accounting for 82.5%(P＜0.05).The duration of fever,cough,dyspnea,and lung rale,and hospital stay were significantly shorter than those in the routine treatment group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions was 7.5%in the adjuvant treatment group and 5.0%in the conventional treatment group,which was not displayed a significant difference between the two groups(P＞0.05).ConclusionThe effect of dopamine combined with phentolamine in the treatment of severe pneumonia in children is remarkable with few adverse reactions，worthy of clinical application.
2018 Vol. 25 (2): 86-88 [Abstract] ( 159 ) HTML (24 KB)  PDF  (0 KB)  ( 73 )
89 Changes of myocardial zymogram in neonates with hypoxic ischemic encephalopathy and its relationship with brain injury after asphyxia
CHEN Xu-sheng;HUANG Bi-jun ;ZHAO Xuan-zhu
ObjectiveTo analyze the changes of myocardial zymogram in neonates with HIE and its relationship with brain injury after asphyxia.Methods76 children with HIE in our hospital from February 2015 to February 2017 were collected.According to their severity,they were divided into mild group 26 cases,moderate group 30 cases and severe group 20 cases.All the children were detected by automatic biochemical analyzer,and the level of myocardial zymogram was analyzed.After two groups of treatment were completed,they were divided into 70 groups with good prognosis and 6 cases with poor prognosis.The levels of myocardial enzymes were collected and compared between the two groups.ResultsWith the increase of the severity of the disease,the myocardial zymogram level of HIE patients showed a rising trend,and showed a significant positive correlation with myocardial enzyme spectrum (r=0.485,P＜0.05).The myocardial zymogram level of the patients with poor prognosis was significantly higher than that of the prognosis group,the difference was statistically significant(P＜0.05).ConclusionThe occurrence and development of HIE will lead to a larger change of myocardial enzyme spectrum,so by analyzing the changes of myocardial enzyme spectrum can determine the severity of the HIE patients.Especially,it can accurately understand brain injury,also can guide the analysis of the prognosis,with a high clinical value.
2018 Vol. 25 (2): 89-91 [Abstract] ( 159 ) HTML (24 KB)  PDF  (0 KB)  ( 62 )
92 Explore the effect of biofeedback combined with electrical stimulation rehabilitation therapy on the delivery of pregnant women
ZHANG Hai-xia
ObjectiveTo investigate the effects of the combined electrostimulation rehabilitation method on maternal selection of biofeedback and the effects of post-delivery.Methods100 cases of pregnant women who were admitted to our hospital from January 2016 to January 2017 were selected as experimental subjects.According to the number of parity were divided into control group(50 cases)and observation group(50 cases).The control group was treated with pelvic floor rehabilitation training;Observe biofeedback electric stimulation combined with rehabilitation training;rehabilitation treatment effects were compared between the two groups.ResultsThe total effective rate of pelvic floor muscle improvement in the observation group was higher than that the control group,and the difference was statistically significant(P＜0.05).In the observation group and the control group，the improvement of pelvic floor muscle strength was higher than before the treatment,and the difference was statistically significant(P＜0.05).Compared between groups,the observation group was higher than the control group,and the difference was statistically significant(P＜0.05).The observation group and control group 16 weeks after treatment maternal vaginal muscles voltage higher than 6 weeks after treatment,the difference was statistically significant(P＜0.05),the comparison between groups,the observation group was higher than the control group,the difference was statistically significant(P＜0.05).In the observation group and control group,the number of night urine was less than 6 weeks after treatment,and the difference was statistically significant(P＜0.05).Compared between groups,the observation group was less than the control group,and the difference was statistically significant(P＜0.05).ConclusionCompared with the pure pelvic floor rehabilitation training,biofeedback joint electrical stimulation methods of rehabilitation can significantly enhance maternal pelvic floor muscle strength and increase the degree of vaginal tightening,effectively improve the quality of life,after giving birth to a child is worth wide application in the clinical practice.
2018 Vol. 25 (2): 92-94 [Abstract] ( 154 ) HTML (25 KB)  PDF  (0 KB)  ( 87 )
95 Effect comparison of autologous ossicular chain and artificial ossicular chain in the treatment of chronic otitis media with hearing impairment
LIN Si-ping;ZHANG Zhi-gang
ObjectiveTo evaluate the clinical effect of autologous ossicular chain and artificial ossicular chain in the treatment of chronic otitis media with hearing impairment.MethodsClinical data of 78 patients with chronic otitis media who underwent ossicular reconstruction from February 2014 to October 2016 in our hospital and the Second Hospital Affiliated to Zhongshan Medical Sciences University were retrospectively analyzed.According to the different ossicular chain reconstruction material,they were divided into the autologous ossicular chain group(n=47)and artificial ossicular chain group (n=31).The hearing improvement before surgery and after 6 months surgery and occurrence of complications in patients between the two groups were compared.ResultsThe bone-conduction threshold and air-conduction threshold in pure tone test and the air-bone gap (ABG)before surgery were not displayed significant differences between the two groups (P＞0.05).After 6 months surgery,the bone-conduction threshold and air-conduction threshold in pure tone test and ABG of the artificial ossicular chain group was lower than that of those of the autologous ossicular chain group (P＜0.05).There was no great difference of the incidence of postoperative complications between the two groups(P＞0.05).ConclusionArtificial ossicular chain reconstruction in the treatment of chronic otitis media with hearing impairment can remarkably decrease the hearing threshold,improve hearing,and obtain a favorable clinical effect.
2018 Vol. 25 (2): 95-97 [Abstract] ( 130 ) HTML (25 KB)  PDF  (0 KB)  ( 73 )
98 Application value of micro-implant anchorage in the treatment of oral orthodontic treatment of adolescents
ZHAI Ma-li
ObjectiveTo explore the application value of micro-implant anchorage in the treatment of oral orthodontic treatment of adolescents.Methods100 adolescents given oral orthodontic treatment treated in our hospital from August 20,2014 to May 22,2016 were selected as object.They were grouped according to their different treatment method,and there were 50 cases in each group.The control group received non-implant anchorage therapy,while the experimental group received micro-implant anchorage treatment.Treatment effect between the two groups was compared.ResultsThe treatment success rate (100.00%)of the experimental group was significantly higher than that of the control group(76.00%)，and the incidence of adverse reaction (discomfort,mild edema,oral infection)in the experimental group was obviously lower than that of the control group (P＜0.05).In the experimental group,the incision angle difference and the convexity difference of the upper and middle incisors were greater than those of the control group,and molar displacement distance was shorter than that of the control group(P＜0.05).ConclusionAdolescent oral orthodontic treatment patients given the micro-implant support treatment can achieve a better effect,and the incidence of adverse reaction is lower,the application value is higher.
2018 Vol. 25 (2): 98-100 [Abstract] ( 149 ) HTML (24 KB)  PDF  (0 KB)  ( 67 )
101 Application effect of Dexmedetomidine in patients undergone radical resection of esophageal cancer by total endoscope
XIAO Zhuo-hui
ObjectiveTo investigate the application effect of Dexmedetomidine in patients undergone radical resection of esophageal cancer by total endoscope.MethodsFrom January 2015 to June 2017,56 patients accepted radical resection of esophageal cancer under total endoscope were selected and evenly divided into the observation group and the control group by a random number table method.In the observation group,Dexmedetomidine was pumped after tracheal intubation for general anesthesia,while in the control group,the same amount of normal saline was pumped.The operation effect,and the VAS and NRS scores in the two groups were observed and compared.ResultsIn the observation group,the recovery time of spontaneous breathing,eye-opening time,and extubation time were all significantly shorter than those in the control group (P＜0.05).The incidence of complications and intraoperative awareness rate in the observation group were both greatly lower in comparison with those in the control group (P＜0.05).The VAS and NRS scores in the observation group were significantly lower compared with those in the control group(P＜0.05).ConclusionFor patients undergone radical resection of esophageal cancer by total endoscope,application of Dexmedetomidine can markedly shorten the extubation time and respiratory recovery time,and decreases the scores of VAS and NRS,which is worthy of promotion and application.
2018 Vol. 25 (2): 101-103 [Abstract] ( 136 ) HTML (26 KB)  PDF  (0 KB)  ( 66 )
104 Influence of Dexmedetomidine,Dezocine and Tramadol on the general anesthesia recovery quality
HAN Ming-jie;YE Lin-yang
ObjectiveTo explore the influence of Dexmedetomidine,Dezocine and Tramadol on postoperative shivering and emergence agitation in patients anesthetized with Sevoflurane undergoing laparoscopic nephrectomy,and haemodynamic stability during extubation.Methods160 patients with kidney cancer in our hospital,American Society of Anesthesiologists(ASA)Ⅰ-Ⅱ,undergoing laparoscopic nephrectomy from January to October in 2016 were selected and divided into the Dexmedetomidine(Dex)group,the Dezocine(Dez)group,the Tramadol(Tra)group,the 0.9%Sodium Chloride Solution(Con)group according to the random number table method,40 cases in each group.All patients were anesthetized with Sevoflurane (≥0.6 MAC)supplemented by Remifentanil 0.15-0.30 μg/(kg·min)after anesthesia induction.The Dex group received 1 mg/kg of Dexmedetomidine,the Dez group received 0.1 mg/kg of Dezocine,the Tra group received 1 mg/kg of Tramadol,the Con group received 0.9%normal saline 30 minutes before the end of surgery.The incidence of postoperative shivering and emergence agitation,the time of autonomous respiration,eye opening,extubation and the mean arterial pressure(MAP),hear rate(HR),Riker Sedation-Agitation Scale and Rameasy sedation score,SpO2were compared at the last three time points and 1,5,10,20,30 min after extubation.ResultsThe incidence of shivering in the three groups of Dex,Dez and Tra were 32.5%,32.5%and 7.5%respectively,which was significantly lower than that of the Con group (57.5%)(P＜0.05),the incidence of shivering in the Tra group was significantly lower than that in the Dex and Dez group (P＜0.05).The incidence of emergence agitation in the Tra,Dez and Dex groups were 40.0%,12.5%and 10.0%,respectively,which was significantly lower than that in the Con group(70.0%)(P＜0.05).The incidence of emergence agitation in the Tra group was significantly higher than that in the Dex and Dez group (P＜0.05).The levels of HR and MAP in the Dex,Dez,and Tra group at T3,T4and T5were significantly lower than those of the Con group (P＜0.05).The level of HR and MBP at T3,T4,and T5in the Con group was significantly higher than that at T1(P＜0.05).The level of HR and MAP at T3and T4in the Dex and Dez group was significantly lower than that in the Tra group (P＜0.05).ConclusionAdministration of Dexmedetomidine (1 μg/kg),Dezocine (0.1 mg/kg)or Tramadol(1 mg/kg)at 30 minutes before the end of surgery can reduces postoperative shivering and emergence agitation,and attenuates the hemodynamic response to extubation in patients receiving Sevoflurane anesthesia for laparoscopic nephrectomy.
2018 Vol. 25 (2): 104-108 [Abstract] ( 152 ) HTML (43 KB)  PDF  (0 KB)  ( 52 )
109 Influence of Remifentanil combined with Propofol on hemodynamics in transcervical resection of adhesions
HU Shuai
ObjectiveTo observe the influence of Remifentanil and Propofol on hemodynamics in transcervical resection of adhesions.Methods100 cases of intrauterine adhesions underwent transcervical resection of adhesions from February 17,2015 to February 17,2017 in our hospital were selected and divided into the control group and the observation group according to the random number table methods,50 cases in each group.The control group was given with Remifentanil,and the observation group was given Rremifentanil combined with Propofol anesthesia.The index of hemodynamics,the wake-up time,as well as the extubation time of the two groups were compared.ResultsThe MAP level in extubation in the control group was higher than that before the induction,with significant difference (P＜0.05).The level of HR and MAP of the observation group at 20 min of operation begins,before extubation,at 5 min after extubation was lower than that before the operation,with significant difference(P＜0.05).There was no significant difference in the level of HR and MAP between the two groups before induction(P＞0.05).The level of HR and MAP of the observation group at 20 min of operation begins,before extubation,at 5 min after extubation was lower than that of the control group,with significant difference (P＜0.05).The wake-up time and the extubation time in the observation group were shorter than those in the control group,with significant difference(P＜0.05).ConclusionApplication of Remifentanil combined with Propofol has a lower influence of hemodynamics in transcervical resection of adhesions,the effect of anesthesia is good,and it has good clinical promotion value.
2018 Vol. 25 (2): 109-111 [Abstract] ( 134 ) HTML (24 KB)  PDF  (0 KB)  ( 54 )
112 Application effect of different nerve block methods in the internal fixation of patients with clavicle fractures
LIU Chun-gen;LUO Yu-lan;HUANG Hong-zhou
ObjectiveTo explore the application effect of different nerve block methods in the internal fixation of patients with clavicle fractures.MethodsFrom January 2015 to January 2017,80 patients with clavicle fracture who were treated by internal fixation in our hospital were selected.The patients were evenly divided into the control group and the observation group in random,40 cases in each group.In the control group,simple neck block anesthesia was used,while in the observation group,the combined cervical and brachial plexus block anesthesia was adopted.The anesthetic effect and complications were compared between the two groups.ResultsThere was no significant difference in the heart rate and NIBP between the two groups before anesthesia (P＞0.05).The heart rate and NIBP during slicing and reduction of fracture in the observation group were higher than those in the control group,with significant difference (P＜0.05).There was no significant difference in the heart rate between the two groups at 24 h after operation(P＞0.05).The NIBP at 24 h after operation in the observation group was lower than that in the control group,with significant difference(P＜0.05).The excellent and good rate of anesthesia in the observation group was much better than that in the control group,with statistical difference(P＜0.05).The postoperative incidence of complications in the observation group was lower than that in the control group,which was displayed statistical significance (P＜0.05).ConclusionFor patients with clavicle fractures,application of combined cervical and brachial plexus block anesthesia for internal fixation can obtain a remarkable effect,which is beneficial to improve the anesthetic effect and alleviate the severity of nerve injury in a great clinical value.It is worthy of extensively promoted.
2018 Vol. 25 (2): 112-114 [Abstract] ( 132 ) HTML (26 KB)  PDF  (0 KB)  ( 36 )
115 Effect comparison of Tramadol Hydrochloride,Dezocine,Sufentanil,Hydromorphone Hydrochloride in the prevention and treatment of hypersensitivity pain after Remifentanil combined anesthesia
HUA Bing
ObjectiveTo compare the clinical effect of Tramadol Hydrochloride,Dezocine,Sufentanil,Hydromorphone Hydrochloride in the prevention and treatment of hypersensitivity pain after Remifentanil combined anesthesia.Methods157 patients with ASA gradeⅠ-Ⅱ who underwent gynecological laparoscopic surgery in our hospital from March 2015 to June 2017 were enrolled in this study,according to the different drugs used before surgery,the patients were divided into group A(Tramadol Hydrochloride,34 cases),group B(Dezocine,43 cases),group C(Sufentanil,39 cases)and group D(Hydromorphone Hydrochloride,41 cases).The recovery time and extubation time,extubation heart rate (HR)and mean arterial pressure (MAP)were compared between the four groups,the VAS scores and Ranmsay sedation scores were compared between the four groups at 15 minutes,1 h,2 h,4 h,8 h,16 h and 24 h postoperatively,and the incidence of adverse reactions during and after extubation in 24 hours were compared.ResultsThe recovery time and extubation time of group D were significantly shorter than those of group A,group B and group C (P＜0.05),and those of group B and group C were significantly shorter than those of group A(P＜0.05),there was no significant difference between the group B and group C in the recovery time and extubation time (P＞0.05).The HR and MAP of extubation of group D were significantly lower than those of group A,group B and group C (P＜0.05),the HR and MAP of extubation of group B and group C were also significantly lower than those of group A (P＜0.05),and there was no significant difference between the group B and group C in the HR and MAP of extubation(P＞0.05).The VAS score at 2 hours to 24 hours after operation in group D were significantly lower than those of group A,group B and group C (P＜0.05),while those of group B and group C were significantly lower than those of group A (P＜0.05),there was no significant difference between group B and group C in the VAS score at 2 hours to 24 hours after operation (P＞0.05).The ramsay sedation scores at 15 minutes to 2 hours after operation in group D were obviously better than those of group A,group B and group C (P＜0.05),those of group B and group C were obviously better than that of group A (P＜0.05),there was no significant difference between group B and group C in the ramsay sedation scores at 15 minutes to 2 hours after operation(P＞0.05).The incidence of adverse reactions in the four groups after extubation and postoperative 24 h was group A＞group B＞group C＞group D,the differences were statistically significant(P＜0.05).ConclusionIn the prevention and treatment of Remifentanil after anesthesia,the effect of Hydromorphone Hydrochloride is the most obvious,it does not affect the recovery and extubation time of the patients,and the incidence of adverse reactions is also the lowest,followed by Dezocine and Sufentanil,both are quite effective,but the adverse effects of Sufentanil postoperative complication rate is lower,and Tramadol Hydrochloride is the worst.
2018 Vol. 25 (2): 115-118转122 [Abstract] ( 141 ) HTML (34 KB)  PDF  (0 KB)  ( 69 )
119 Influence of low dose Ketamine combined with Lidocaine on stress response and preemptive analgesia in patients undergoing hysteromyoma surgery
LIU Rong-wei
ObjectiveTo investigate the influence of low dose Ketamine combined with Lidocaine on stress response in patients undergoing hysteromyoma surgery.Methods135 patients with ASAⅠ-Ⅱ hysteromyoma underwent surgical treatment from March 2015 to June 2017 in our hospital were selected and randomly divided into group A,group B and group C,with 45 patients in each group.Patients in group A received postoperative analgesia.Group B patients received preemptive analgesia with Ketamine at 30 min before surgery,and group C patients were given low dose Ketamine and Lidocaine preemptive analgesia.The operation conditions,the visual analogue scales,the indexes of stress reaction and the incidence of adverse drug reactions of the three groups were compared.ResultsAll patients completed the operation successfully.There was no significant difference in the operation time,intraoperative bleeding volume,postoperative exhaust time and bed time and surgery related indicators between the three groups(P＞0.05).The VAS score at 6-12 hours after operation in the three groups was significantly lower than that at 1 h after operation(P＜0.05).The scores of VAS at 6-12 hours after operation in group C were significantly lower than those of group A and group B,with significant difference(P＜0.05).The use rate of postoperative analgesic medication in group C was significantly lower than that of group A and group B(P＜0.05).There was no significant difference in the use rate of postoperative analgesic medication between group A and group B (P＞0.05).The levels of adrenocortical hormone,norepinephrine and cortisol in 6,24 h after operation were significantly higher than that in the three groups after operation at once (P＜0.05).The levels of adrenocortical hormone,norepinephrine and cortisol at 6,24 h after operation of group C were significantly lower than those of group A and group B (P＜0.05).There was no significant difference in the levels of adrenocortical hormone,norepinephrine and cortisol at 6,24 h after operation between group A and group B (P＞0.05).There was no significant difference in the incidence of adverse drug reactions between the three groups(P＞0.05).ConclusionLow dose Ketamine combined Lidocaine preemptive analgesia in patients with hysteromyoma can effectively relieve postoperative pain,reduce the stress response of patients,reduce the damage to the body,and do not increase adverse reactions,it is worthy of clinical popularization and application.
2018 Vol. 25 (2): 119-122 [Abstract] ( 141 ) HTML (29 KB)  PDF  (0 KB)  ( 62 )
123 The influence of Trimetazadine on the clinical efficacy of patients with chronic heart failure
ZHANG Bo
ObjectiveTo evaluate the effects of Trimetazadine on patients with chronic heart failure.Methods100 patients with chronic heart failure treated in our hospital form February 2016 to February 2017 were selected as the subjects,and divided into therapy group and control group,50 cases in each group.The control group patients were given basic treatment with angiotensin converting enzyme inhibitor(ACEI),digitalis,diuretics,βblock.And the therapy group were given Trimetazadine in addition to the basic treatment.Heart function,LVEF,LVDD,LVDS and BNP level in those patients were observed before and after three months treatment.ResultsCompared with the control group,the total effective rate increased significantly in the therapy group.After treatment,the LVEF of the patients was obviously improved,and RHR in therapy group was decreased.LVDD,LVDS and BNP level also decreased at 3 months compared with those in therapy group,the difference was statistically significant(P＜0.05).ConclusionIn additional to the conventional therapy,Trimetazadine can improve the left ventricular performance and remodeling in patients with coronary heart failure.
2018 Vol. 25 (2): 123-125 [Abstract] ( 150 ) HTML (26 KB)  PDF  (0 KB)  ( 59 )
126 Effect of modified peanut skin on prevention and treatment of tumor chemotherapy-related thrombocytopenia
GE Yun;WANG Qin;XU Dong;WANG Ke-shan

ObjectiveTo observe the effect of modified peanut skin in the prevention and treatment of chemotherapyrelated thrombocytopenia.MethodsFrom October 2014 to February 2017,132 patients with malignant tumor associated thrombocytopenia were enrolled as observation objects.They were randomly divided into treatment group (n=64)and control group (n=68).In the treatment group,the modified peanut skin was provided besides chometherapy,while in the control group,no preventive measure was used.The minimum value of platelet,the duration of platelet less than 75×109/L and less than 100×109/L,the degree of thrombocytopenia,and adverse reactions after chemotherapy were observed in two groups.ResultsAfter two-cycle chemotherapy,the minimal PLT in the treatment group was higher than that in the control group,but without significant difference(P＞0.05).The duration of platelet less than 75×109/L and less than 100×109/L in treatment group were significantly shorter than that in control group,the difference was significant difference (P＜0.05).In the treatment group,the decrease degree of thrombocytopenia was lower than that in the control group with a statistical difference(P＜0.05).No bleeding was recurred.ConclusionPreventive application of modified peanut skin can reduce the amplitude of platelet induced by chemotherapy and shorten the duration of thrombocytopenia,which is worthy of clinical promotion.
2018 Vol. 25 (2): 126-128 [Abstract] ( 157 ) HTML (27 KB)  PDF  (0 KB)  ( 55 )
129 Tiotropium bromide in the treatment of COPD and its impact on quality of life
WEN Zhi-guang
ObjectiveTo investigate the effect of Tiotropium Bromide in the treatment of chronic obstructive pulmonary disease (COPD)and its influence on the quality of life.Methods100 patients with COPD from February 2014 to December 2016 treated in our hospital were selected as the subjects,and randomly divided into control group and study group,with 50 cases in each group.The control group was given conventional treatment,and the study group was treated with Tiotropium Bromide on the basis of the control group the clinical efficacy,pulmonary function index,blood gas index,6 min walking distance(6MWD),quality of life score and incidence of adverse reactions were compared between the two groups.ResultsThe tatal clinical effective rate of the study group(90.00%)was significantly higher than that of the control group (72.00%),the difference was statistically significant(P＜0.05).Before intervention,there was no significant difference in pulmonary function index and 6MWD between the two groups(P＞0.05).After intervention,the FEV1,FVC,FEV1%and 6MWD in the two groups were significantly increased,and the study group was higher than that of the control group (P＜0.05).Before intervention,there was no significant difference in blood gas index between the two groups(P＞0.05).After intervention,the two groups of PaO2were increased,PaCO2decreased,and the study group was significantly changed compared with the control group,the difference was statistically significant(P＜0.05).Before intervention,there was no significant difference in the quality of life score between the two groups(P＞0.05).After intervention,the quality of life scores of the two groups were decreased,and the study group was lower than that of the control group (P＜0.05).Two groups of patients the incidence of adverse reactions was not statistically significant(P＞0.05).ConclusionTiotropium Bromide in the treatment of COPD can significantly improve the lung function and quality of life of patients,improve exercise endurance,curative effect is exact,and the clinical application has certain security.
2018 Vol. 25 (2): 129-131 [Abstract] ( 173 ) HTML (28 KB)  PDF  (0 KB)  ( 71 )
132 Analysis of adverse reaction and rational use of antibiotics
ZHOU Bing;QIAO Shou-cui
ObjectiveTo analyze the adverse reaction and rational use of antibiotics.MethodsThe clinical data of 60 patients with adverse drug reactions from January to December in 2016 were analyzed retrospectively in pharmacy.The varieties of antibiotics causing adverse reactions were calculated,and adverse reactions-involved systems and clinical manifestations were analyzed.ResultsAmong the 60 patients with adverse drug reactions,there were seven kinds of drugs including cephalosporins,penicillin,macrolides,aminoglycosides,quinolones,tetracycline,and nitrate imidazoles.The five systems involved skin and its accessory system,digestive system,nervous system,cardiovascular system,and respiratory system.ConclusionThere are various adverse reactions caused by antibiotics,which affect the curative effect in patients.Therefore,we should strengthen the rational drug use,reduce the incidence of adverse reactions,and ensure its safety.
2018 Vol. 25 (2): 132-134 [Abstract] ( 165 ) HTML (25 KB)  PDF  (0 KB)  ( 77 )
135 Comparison of the effects of imipenem and cefepime in the treatment of severe pneumonia in children
ZHOU Zhi-hao
ObjectiveTo compare the efficacy of imipenem and cefepime in the treatment of severe pneumonia in children.MethodsFrom February 2014 to February 2016,50 cases of children with severe pneumonia were selected as the research object.The patients were divided into the study group and the reference group according to the order before and after the visit,25 cases in each group.The reference group was treated with cefepime,and the study group was treated with imipenem.The clinical treatment effects of the two groups were compared.ResultsThe total efficiency of the study group after treatment(96%)was significantly higher than that of the control group(80%),with a significant difference (P＜0.05).Pulmonary rales in study group after treatment,the body temperature returned to normal time,the disappearing time of clinical symptoms,X-ray absorption time,antibiotic use time and hospital stay time were shorter than those in the reference group.The difference was statistically significant(P＜0.05).The WBC,PaO2,PaO2/FiO2indicators in the study group after treatment were better than those in the reference group,the difference was statistically significant(P＜0.05).ConclusionThe implementation of statin therapy,imipenem and the Secretary for children with severe pneumonia were good effect,which is worth popularizing.
2018 Vol. 25 (2): 135-137 [Abstract] ( 186 ) HTML (27 KB)  PDF  (0 KB)  ( 81 )
138 Comparison of efficacy and safety between tacrolimus and leflunomide in the treatment of idiopathic membranous nephropathy
WANG Tian-qi;YANG Ying-da
ObjectiveTo compare the efficacy and safety of tacrolimus and leflunomide in the treatment of idiopathic membranous nephropathy.Methods80 patients with membranous nephropathy treated in our hospital from June 2015 to January 2017 were selected as the subjects,and divided into control group and observation group according to random data table method,40 cases in each group.All patients were treated with prednisone regularly.In addition,patients in the control group were treated with leflunomide,and patients in the observation group were treated with tacrolimus,6 months for a course of treatment.The difference of clinical efficacy between the two groups was compared.ResultsAfter treatment,the renal function indexes such as 24 h urinary protein and serum creatinine in the observation group were lower than those in the control group,the difference was statistically significant(P＜0.05).Triglyceride (TG),total cholesterol(TC)and other blood lipid levels in the observation group were lower than those in the control group,the difference was statistically significant(P＜0.05).The total effective rate of the observation group (77.50%)was higher than that of the control group (55.00%),the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group(30.00%)was higher than that of the control group(13.33%),the difference was statistically significant (P＜0.05).ConclusionFor leflunomide,tacrolimus is more effective in the treatment of idiopathic membranous nephropathy.Tacrolimus can effectively improve renal function and blood lipid levels,safe and reliable,which is worthy of promotion.
2018 Vol. 25 (2): 138-140转144 [Abstract] ( 170 ) HTML (27 KB)  PDF  (0 KB)  ( 60 )
141 Analysis on the use of hypoglycemic drugs in the Second People′s Hospital of Fuxin City from 2015 to 2016
ZHOU You-zhi
ObjectiveTo investigate the clinical application of diabetes drugs in the hospital and provide basis for the rational use of drugs.MethodsThe usage information of insulin analogues and oral hypoglycemic agent in our hospital computer from January 2015 to December 2016 were selected as the subjects.The sales amount and proportion of oral hypoglycemic agent and insulin analogues,sales volumes,usage rate and sales amount of various drugs were analyzed.ResultsIn the sales amount of hypoglycemic drug,insulin analogs was close to oral hypoglycemic agent of our hospital in 2015 and 2016,and each accounted for 50%.Among 11 kinds of insulin preparations,the premixed insulin utilization rate was higher,reaching 30%on average.The use rate of protamine zinc insulin was low,coming up to 5%on average.In terms of oral glucose-lowering drugs,biguanide utilization was higher,reaching 50%on average.ConclusionThe hospital has varieties of antiglycemic drugs and can basically meet the demands of rational clinical use.
2018 Vol. 25 (2): 141-144 [Abstract] ( 134 ) HTML (26 KB)  PDF  (0 KB)  ( 77 )
145 Effect observation of ribavirin injection combined with tanreqing ultrasonic atomization in the treatment of viral pneumonia in influenza virus infection
ZHANG Tong
ObjectiveTo investigate the effect of Ribavirin Injection combined with Tanreqing ultrasonication in the treatment of viral pneumonia caused by influenza virus infection.MethodsA total of 100 patients with viral pneumonia enrolled in our hospital from October 2013 to October 2016 were selected as the subjects,and divided into two groups according to the time difference of treatment,50 cases in each group.The patients in the control group were treated with Ribavirin Injection alone.The patients in the experimental group were treated with Ribavirin Injection combined with Tanreqing ultrasonication.The disappearance time and the final curative effect of the clinical symptoms between the two groups were compared.ResultsTwo groups of patients with symptoms,signs and clinical symptoms disappeared time comparison,the experimental group was significantly shorter than the control group,the difference was statistically significant(P＜0.05).The experimental group and the control group eventually curative effect,the total effective rate in the experimental group was significantly higher than the control group,the difference was statistically significant(P＜0.05).ConclusionThe use of Ribavirin Injection combined with Tanreqing ultrasonic atomization in the treatment of influenza virus infection caused by viral pneumonia is significant and can improve rapidly with little side effects of drugs,which has the value of popularization.
2018 Vol. 25 (2): 145-147 [Abstract] ( 158 ) HTML (25 KB)  PDF  (0 KB)  ( 74 )
148 Effect and safety of Qishenyiqi Drop Pills combined with Methylcobalamin in treatment of diabetic peripheral neuropathy
FU Fang-liang;LI Yin-di;ZHANG Ou
ObjectiveTo study the effect and safety of Qishenyiqi Drop Pills combined with Methylcobalamin in treatment of diabetic peripheral neuropathy.Methods90 patients with diabetic peripheral neuropathy (qi deficiency and blood stasis type)treated in our hospital from August 2015 to May 2017 were enrolled in the study and randomly grouped according to the random data table method.45 patients in the control group were treated with Methylcobalamin Injection,while 45 patients in the observation group were treated Methylcobalamin Injection combined with Qishenyiqi Drop Pills.12 weeks were a course of treatment.The improvement of lower limb nerve conduction velocity,the clinical efficacy and the incidence of adverse reactions were compared between the two groups.ResultsAfter treatment,the motor conduction velocity of the tibial nerve and the common peroneal nerve in the observation group were quicker than those in the control group,the difference was statistically significant(P＜0.05).The total effective rate of the observation group was 88.89%,which was higher than that of the control group(68.89%)(P＜0.05.The total incidence of adverse reactions was 6.67%in the observation group and it was 4.44%in the control group,the difference was not statistically significant(P＞0.05).ConclusionQishenyiqi Drop Pills combined with Methylcobalamin is effective in the treatment of diabetic peripheral neuropathy,which can improve nerve conduction function,it is safe and reliable,it is better than single western medicine treatment,and it is worthy of promotion.
2018 Vol. 25 (2): 148-150 [Abstract] ( 175 ) HTML (26 KB)  PDF  (0 KB)  ( 56 )
151 Influence of Astragalus Granules combined with Montelukast sodium on pulmonary function and life quality in children with cough variation asthma
QUAN Shou-dong
ObjectiveTo investigate the influence of Astragalus Granules combined with Montelukast sodium on pulmonary function and life quality in children with cough variation asthma.MethodsEighty-eight children with cough variation asthma treated in outpatient of Department of Pediatrics in the Second Hospital of Chaoyang City from January 2014 and December 2016 were selected and they were randomly divided into the control group (n=44)and the treatment group (n=44).The two groups were given Montelukast sodium treatment,at the same time,on the basis of this,the treatment group was given oral Astragalus Granules,and patients were treated for 3 months.The clinical efficacy between the two groups was compared,and the lung function and the life quality before and after the treatment between the two groups were compared.ResultsThe total effective rate in the treatment group was significantly higher than that in the control group(95%vs.86%,P＜0.05).The lung function of the treatment group after treatment was better than that of the control group(P＜0.05).After treatment,each dimension score and total score of life quality in the treatment group were significantly higher than those before treatment(P＜0.05),but the symptoms and activity scores in the control group were significantly higher than those before treatment(P＜0.05).The score of each dimension and total score of the life quality in the treatment group were significantly higher than those in the control group(P＜0.05).ConclusionAstragalus Granules combined with Montelukast sodium can obviously improve the lung function and life quality in disease children,and improve the clinical effect.
2018 Vol. 25 (2): 151-153 [Abstract] ( 164 ) HTML (27 KB)  PDF  (0 KB)  ( 61 )
154 Effect of Bufei Huayu Tongluo Decoction assisting on regular therapy of western medicine in the treatment of chronic pulmonary embolism
LIU Fang
ObjectiveTo analyze the effect of Bufei Huayu Tongluo Decoction assisting on regular therapy of western medicine in the treatment of chronic pulmonary embolism.MethodsFrom July 2015 to February 2017,the clinical data of 16 patients diagnosed as chronic pulmonary embolism were selected and divided into the control group(n=8)and research group (n=8)in random.In the control group,patients were treated by routine western medicine,while in the research group,besides western medicine,Bufei Huayu Tongluo Decoction as an adjuvant therapy was added.After 2 months treatment,the therapeutic effect,coagulation function indicators (PT,PLT,FIB),pulmonary function indexes(FEV1%prep,FEV1/FVC),serum high mobility group protein B-1 (HMGB-1)and the incidence of adverse symptoms were compared between the two groups.ResultsAfter treatment,the total effective rate in the research group (87.50%)was much higher than that in the control group (75.00%)(P＜0.05).PT of the research group was significantly longer than that of the control group,and the level of PLT and FIB were significantly higher than those of the control group,and FEV1%prep and FEV1/FVC were significantly better than those of the control group,while HMGB-1 was lower than that of the control group,with a statistically significant difference (P＜0.05).There was no statistical difference of the incidence of adverse symptoms between the two groups(P＞0.05).ConclusionBufei Huayu Tongluo Decoction assisting on routine treatment of western medicine treating chronic pulmonary embolism can significantly improve the coagulation function and pulmonary function,and the incidence of adverse symptoms is low,which can be promoted in grass-root hospital.
2018 Vol. 25 (2): 154-156 [Abstract] ( 142 ) HTML (28 KB)  PDF  (0 KB)  ( 74 )
157 Clinical effect of Shugan Jieyu Capsules combined with Duloxetine in the treatment of depression in patients with parkinson disease
YAO Xu-dong; LIU Fang
ObjectiveTo observe the clinical effect of Shugan Jieyu Capsules combined with Duloxetine in the treatment of depression in patients with parkinson disease (PD).Methods73 PD patients with depression treated in outpatient of the psychiatry department of our hospital from February 2016 to June 2017 were selected as object and they were randomly divided into the control group (36 cases)and combined group (37 cases).Patients in the control group were treated with Duloxetine Hydrochloride Enteric-coated Tablets,while the patients in the combined group were treated with Shugan Jieyu Capsules at the same time.4weeks were a course of treatment and the patients were treated continuously for 2 courses.The score of HAMD,UPDRS-Ⅲand ADL before treatment and at the fourth,eighth week of treatment were compared in patients between the two groups.At the eighth week of treatment,the treatment effect between the two groups was compared according to HAMD reduction rate,and the incidence of adverse reactions during the treatment of the two groups was compared at the same time.ResultsAt the fourth and eighth weeks treatment,the score of HAMD,UPDRS-Ⅲin the two groups were significantly decreased,ADL score was obviously increased,and there was a statistical difference compared with before treatment(P＜0.05).At the eighth weeks treatment,the score of HAMD and UPDRS-Ⅲ of the patients in the combined group were significantly lower than those in the control group(P＜0.05)and at the fourth and eighth weeks treatment,ADL score of the patients in the combined group was significantly higher than that in the control group(P＜0.05).At the eighth weeks,the total effective rate of the patients in the combined group was 91.89%,which was significantly higher than that of the control group (71.31%)(P＜0.05).The incidence of adverse drug reactions in the combined group was 13.51%,compared with 19.44%in the control group,the difference was not statistically significant(P＞0.05).ConclusionThe combination of Shugan Jieyu Capsules combined with Duloxetine is effective in the treatment of PD complicated with depression,both can work together to strengthen the effect of depressive symptoms,help improve the daily living ability and exercise ability of patients,and can reduce the incidence of adverse drug reaction,it is worthy of clinical promotion and application.
2018 Vol. 25 (2): 157-159转171 [Abstract] ( 182 ) HTML (27 KB)  PDF  (0 KB)  ( 78 )
160 SWOT analysis of position evaluation in the public hospital
HAO Su-juan
To study the operation effect and strategic significance of post evaluation in public hospital with SWOT analysis,based on the comprehensive reform of medicine separation in Beijing,in order to provide references for other medical institutions to carry out the work.
2018 Vol. 25 (2): 160-162 [Abstract] ( 167 ) HTML (27 KB)  PDF  (0 KB)  ( 74 )
163 Analysis of hidden troubles in pre-hospital first aid and its countermeasures discussion
LIU Jin-song;ZHANG Yong-yan;HE Di-hui;ZHANG Hui-fang; LI Zhong-yuan
Pre-hospital first aid is an important part of modern emergency medical system,and acts as the first link of rescuing patients in severe and critical conditions.The hidden troubles of medical security in pre-hospital first aid frequently occur and are difficult to prevent,which easily lead to medical disputes.Based on the analysis of the hidden dangers in prehospital first aid,this paper summarizes the corresponding preventive measures from six aspects,such as establishing rules,learning relevant laws and regulations,technical training,equipment maintenance,humanistic care,and self-cultivation,and provides reference for implementation of pre-hospital emergency in safe,maintenance of the legitimate rights and interest of both patients and medical personnel,and reduction of medical disputes.
2018 Vol. 25 (2): 163-165 [Abstract] ( 119 ) HTML (27 KB)  PDF  (0 KB)  ( 60 )
166 Observation of the application effect on details management in the nursing management of supply room
HU Bi-hua;YU Ping
ObjectiveTo explore the application value of details management in the nursing management of supply room.MethodsA total of 120 medical staffs in our hospital from January 2015 to December 2016 were selected as the subjects.According to the sequence of selected time,they were divided into the control group (January to December,in 2015)and the research group(January to December,in 2016),with 60 cases in each group.In the control group,the medical staff were provided with traditional nursing management mode in the supply room,and in the research group,the details management mode in the supply room was adopted.The scores of nursing quality of supply room and clinical satisfaction were compared between the two groups.ResultsThe safety recognition ability,risk prevention consciousness,and service awareness in the research group were significantly higher than those in the control group,with significiant differences(P＜0.05).On satisfaction of recovery,packaging,distribution,and service in the research group were all superior to those in the control group,with significiant differences (P＜0.05).ConclusionIn the nursing management of the supply room,application of details management can effectively improve the nursing quality of the supply room and clinical satisfaction,and has a high value for promotion.
2018 Vol. 25 (2): 166-168 [Abstract] ( 127 ) HTML (26 KB)  PDF  (0 KB)  ( 71 )
169 The role of full range nursing in the control of nosocomial infection and nursing quality in blood ward
ZHONG Chun-fang;HU Gui-qiong
ObjectiveTo discuss the role of full range nursing in hospital infection and nursing quality in blood ward.MethodsFrom January 2015 to June 2017,120 patients with hematologic diseases were selected in our hospital,Randomly divided into observation group and control group,60 cases in each group.The patients in the observation group were treated with comprehensive nursing,while the patients in the control group were treated with routine nursing.The infection and nursing quality of the two groups were observed.ResultsThe air quality of the two wards reached the standard(100%),but the number of strains in the air of the observation group was lower than that of the control group(P＜0.05).The total infection rate in the observation group was lower than that in the control group(P＜0.05).The total infection rate of the observation group was lower than that of the control group,the difference was statistically significant(P＜0.05),the satisfaction of the observation group was significantly higher than that of the control group,the difference was statistically significant(P＜0.05).ConclusionAdopting full range nursing in blood ward can reduce the infection rate of patients,improve the quality of nursing,and is helpful to the prognosis of patients.It can be widely used in clinic.
2018 Vol. 25 (2): 169-171 [Abstract] ( 137 ) HTML (24 KB)  PDF  (0 KB)  ( 59 )
172 Influence of nursing intervention on cognitive level and rescue ability of family members of patients with sudden cardiac death at high risk
ZHANG Yong-hong
ObjectiveTo investigate the influence of nursing intervention on the cognitive level and rescue ability of the family members of patients with sudden cardiac death at high risk.Methods92 relatives of high-risk patients with sudden cardiac death admitted to our hospital from December 2012 to November 2016 were divided into the observation group and the control group according to the order of grouping random,46 cases in each group.The observation group was given nursing intervention,and the control group was not given nursing intervention.The cognitive level and rescue ability of the family members of patients were compared between the two groups.ResultsOn admission,the two groups of family members of patients in SCD related diseases and CPR mastery rate between the two groups were no significant difference(P＞0.05),The rate of SCD related diseases in the observation group after 1 month of discharge was significantly higher than that of the control group (P＜0.05),and the mastery rate of 3 d before discharge was significantly higher than that of the control group (P＜0.05).ConclusionNursing intervention can significantly improve the level of cognition and rescue ability of family members of patients with sudden cardiac death at high risk.It is worthy of clinical application.
2018 Vol. 25 (2): 172-174 [Abstract] ( 140 ) HTML (25 KB)  PDF  (0 KB)  ( 67 )
175 The effect of continuity of care on prognosis of patients with coronary heart disease complicated with type 2 diabetes mellitus after PCI.
LIN Xue-jian;HOU Hai-juan;LAI He-ping
ObjectiveTo discuss the effect of continuous nursing on prognosis of patients with coronary heart disease complicated with type 2 diabetes treated by percutaneous coronary intervention(PCI).MethodsFrom may 2014 to April 2016,220 patients with coronary heart disease complicated with type 2 diabetes were enrolled in our hospital.Simple random draw method was used to divide into conventional nursing group and continuous nursing group,110 cases in each group.Different nursing methods were applied to compare the differences of medication compliance,control level of cardiovascular risk factors such as blood pressure,blood lipid,blood glucose and stent restenosis rate between the two groups at one year after operation.ResultsThe medication compliance of the patients in the continuous nursing group was higher than that in the conventional nursing group,and the number of hospital stays in one year.The blood pressure,blood lipid,blood glucose level and stent restenosis rate were lower than those in the conventional nursing group (P＜0.05).ConclusionThe continuity of care improve the self-management level,quality of life and the prognosis in patients of coronary heart disease complicated with type 2 diabetes after PCI.
2018 Vol. 25 (2): 175-178 [Abstract] ( 184 ) HTML (30 KB)  PDF  (0 KB)  ( 69 )
179 The role of continuous health education combined with routine care in peritoneal dialysis patients
CHEN Li-ping;ZHOU Bing;LIU Jie-ru;WEN Chun-lan;CHENG Min-ying;XIE Qing-mei;HUANG Li-fang;FAN Xue-ling
ObjectiveTo explore the clinical effect of continuous health education combined with routine nursing in peritoneal dialysis patients.MethodsFrom February 2014 to December 2016,100 patients with peritoneal dialysis who treated in our hospital,According to the random number method,50 cases in each group were divided into study group and control group were selected.The control group received routine nursing,and the study group received continuous health education combined with routine nursing.The compliance,complications,readmission and nursing satisfaction were compared between the two groups at 8 months after discharge.ResultsThe compliance rate of the study group was significantly higher than that of the control group(P＜0.05),the complication rate and readmission rate in the study group were significantly lower than those in the control group(P＜0.05).The nursing satisfaction of the study group was significantly higher than that of the control group(P＜0.05).ConclusionIn patients with peritoneal dialysis catheter care in the selection of continuing health education combined with routine nursing can effectively improve the compliance behavior of patients,reduce the incidence of complications and readmission rate,conducive to the establishment of a harmonious relationship between nurses and patients.
2018 Vol. 25 (2): 179-181 [Abstract] ( 138 ) HTML (27 KB)  PDF  (0 KB)  ( 64 )
182 Analysis on the application effect of health education of continuous selfefficacy after discharge in the patients after the surgery of benign prostatic hyperplasia
LIU Ying-yun;DENG Jin-tao;WU Min-zhi;PENG Zhi-yong
ObjectiveTo analyze the application effect of continuous self-efficacy health education after discharge in patients with benign prostatic hyperplasia.Methods106 patients discharged from our hospital from September 2015 to March 2017 were selected as the research objects.They were divided into control group and experimental group according to the drawing method,53 patients in each group,The control group was discharged from hospital and the experimental group was given continuous self-efficacy health education after discharge.The differences of health behavior and self-management ability between the two groups before and after intervention were compared.ResultsThere was no significant difference between the two groups(P＞0.05),the self-care ability of the experimental group was better than that of the control group (P＜0.05).The scores of health behavior related dimension after intervention were higher than those before intervention(P＜0.05).The scores of health behaviors in the experimental group were better than those in the control group(P＜0.05).ConclusionThe implementation of continuous self-efficacy health education after discharge for patients after the surgery of benign prostatic hyperplasia plays an important role in improving postoperative health behavior and improving self-care ability,which is worthy of application and promotion.
2018 Vol. 25 (2): 182-184 [Abstract] ( 151 ) HTML (25 KB)  PDF  (0 KB)  ( 67 )
185 Value of airbag biomimetic midwifery in natural delivery of primipara
ZHONG Jie-juan
ObjectiveTo investigate the clinical value of airbag biomimetic midwifery in natural delivery of primipara.Methods80 cases of vaginal delivery from August 2016 to August 2017 were randomly divided into two group.The control group were received routine vaginal delivery.The observation group was supplemented with airbag biomimetic midwifery.Then the maternal first stage of labor and the second time of labor statistics,the two groups of neonatal birth 1 min and 5 min after the Apgar score statistics,the two groups at different time points with pain were compared.ResultsThe Apgar score with 1 min in the observation group was higher than that of the control group(P＜0.05).The Apore score with 5 min in the observation group was higher than that of the control group (P＜0.05).The VAS score in the observation group was significantly lower than control group with the second stage of labor,24 hours postpartum and discharge (P＜0.05).ConclusionFor the first generation of women with balloon bionic midwifery can significantly shorten the labor and reduce maternal pain,so it can improve childbirth safety.
2018 Vol. 25 (2): 185-187 [Abstract] ( 142 ) HTML (26 KB)  PDF  (0 KB)  ( 68 )
188 The effect of family humanistic care on the social functioning of schizophrenia patients who return to communities
ZHU Yan-ling;PENG Yan-ping; HUANG Cai-ming
ObjectiveTo explore the effect of family humanistic care on the social functioning of schizophrenia patients who return to communities.MethodsThe 90 schizophrenia patients were selected from who with Guangzhou city were discharged from my hospital in January to June 2016.They were randomly divided into experimental group and control group with 45 cases in each group.The patients in the experimental group were received humanistic care provided by their family members under rehabilitation nurses′guidance,while in the control group was taken care of by their family members without guidance.The scale for the assessment of negative symptoms(SANS)and the social disability screening schedule(SDSS)were used to assess the outcome of subjects with two groups,when was at baseline and the 6 month after the intervention.ResultsThere were no statistical difference in the two groups of the SANS and SDSS scores before the intervention,the differences were not statistically significant(P＞0.05).After the intervention,the scores of both groups decreased,and there were statistical difference in the experimental group in addition to the marriage,the parents function factor score(P＜0.05),while there were statistical difference in the control group only SANS scores,SDSS scores and social withdrawal factor(P＜0.05).After the intervention,the scores in addition to the marriage and the parents function factor were lower decreased comparison between the experimental group and the control group,the differences were statistically significant(P＜0.05).ConclusionFamily humanistic care shows positive significance in social functioning rehabilitation of schizophrenia patients returning to communities.A positive and healthy home environment can improve the quality of their lives.
2018 Vol. 25 (2): 188-190转193 [Abstract] ( 125 ) HTML (28 KB)  PDF  (0 KB)  ( 67 )
191 Application effect analysis of humanistic nursing in patients with cystoscopy
WANG Wei
ObjectiveTo analyze the application effect of humanistic nursing in patients with cystoscopy.Methods74 patients undergoing cystoscopy in our hospital from February 1,2016 to June 30,2017,were randomly divided into observation group and control group,37 cases in each group.The control group provided routine nursing service,and the observation group provided humanistic care nursing service.The patients in the two study groups were compared in fear level,tension level and pain level.ResultsThe proportion of patients with fear and tension in observation group was higher than that in control group (P＜0.05).The proportion of patients in gradeⅡ andⅢ was significantly lower than that in control group(P＜0.05).The proportion of patients with slight pain and mild pain in observation group was higher than that in control group (P＜0.05).The proportion of patients with severe pain and severe pain was significantly lower than that of the control group (P＜0.05).ConclusionHumanistic care can significantly improve the negative emotions of patients undergoing cystoscopy,and its effect is also reliable in alleviating pain.
2018 Vol. 25 (2): 191-193 [Abstract] ( 125 ) HTML (24 KB)  PDF  (0 KB)  ( 57 )
194 Study on the effect of application of diabetes knowledge WeChat platform in the extended service of diabetes nursing
WU Ping
ObjectiveTo explore the effect of application of diabetes knowledge WeChat platform in the extended service of diabetes nursing.MethodsFrom March 2015 to April 2017,200 patients with diabetes in our hospital were selected as the research objects,and randomly divided into observation group and control group,100 cases in each group.The observation group received diabetes knowledge WeChat platform continuous nursing intervention,while the control group received routine discharge intervention.The self-management ability,blood glucose,hypoglycemia and hospitalization rate,disease awareness rate,medication compliance rate and intervention satisfaction rate were compared between the two groups.ResultsThe excellent rate of self-management ability in the observation group was higher than that in the control group (P＜0.05).The fasting blood glucose and postprandial blood glucose in the observation group were better than those in the control group(P＜0.05).The incidence and hospitalization rate of hypoglycemia in observation group were lower than those in control group (P＜0.05).The disease awareness rate,medication compliance rate and intervention satisfaction rate in the observation group were higher than those in the control group(P＜0.05).ConclusionDiabetes knowledge WeChat platform has great effectiveness in extended service of diabetes nursing.It increases patients′selfmanagement ability,maintains blood glucose stability,decreases hypoglycemia and hospitalization rate,improves disease awareness and medication compliance and satisfaction rate,which should be widely popularized and applied.
2018 Vol. 25 (2): 194-196 [Abstract] ( 131 ) HTML (25 KB)  PDF  (0 KB)  ( 81 )
Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech