疏肝解郁胶囊联合度洛西汀治疗帕金森患者抑郁的临床效果

Abstract
Figure/Table
References (15)
Related Citation (4)

Download: PDF (0 KB) HTML (27 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo observe the clinical effect of Shugan Jieyu Capsules combined with Duloxetine in the treatment of depression in patients with parkinson disease (PD).Methods73 PD patients with depression treated in outpatient of the psychiatry department of our hospital from February 2016 to June 2017 were selected as object and they were randomly divided into the control group (36 cases)and combined group (37 cases).Patients in the control group were treated with Duloxetine Hydrochloride Enteric-coated Tablets,while the patients in the combined group were treated with Shugan Jieyu Capsules at the same time.4weeks were a course of treatment and the patients were treated continuously for 2 courses.The score of HAMD,UPDRS-Ⅲand ADL before treatment and at the fourth,eighth week of treatment were compared in patients between the two groups.At the eighth week of treatment,the treatment effect between the two groups was compared according to HAMD reduction rate,and the incidence of adverse reactions during the treatment of the two groups was compared at the same time.ResultsAt the fourth and eighth weeks treatment,the score of HAMD,UPDRS-Ⅲin the two groups were significantly decreased,ADL score was obviously increased,and there was a statistical difference compared with before treatment(P＜0.05).At the eighth weeks treatment,the score of HAMD and UPDRS-Ⅲ of the patients in the combined group were significantly lower than those in the control group(P＜0.05)and at the fourth and eighth weeks treatment,ADL score of the patients in the combined group was significantly higher than that in the control group(P＜0.05).At the eighth weeks,the total effective rate of the patients in the combined group was 91.89%,which was significantly higher than that of the control group (71.31%)(P＜0.05).The incidence of adverse drug reactions in the combined group was 13.51%,compared with 19.44%in the control group,the difference was not statistically significant(P＞0.05).ConclusionThe combination of Shugan Jieyu Capsules combined with Duloxetine is effective in the treatment of PD complicated with depression,both can work together to strengthen the effect of depressive symptoms,help improve the daily living ability and exercise ability of patients,and can reduce the incidence of adverse drug reaction,it is worthy of clinical promotion and application.

Key words： Parkinson disaese Depression Duloxetine Shugan Jieyu Capsules

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YAO Xu-dong
	LIU Fang

Cite this article:

YAO Xu-dong,LIU Fang. Clinical effect of Shugan Jieyu Capsules combined with Duloxetine in the treatment of depression in patients with parkinson disease[J]. 中国当代医药, 2018, 25(2): 157-159转171.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I2/157

[1]	赵虹，黄华.帕金森病抑郁及认知障碍临床治疗分析[J].中国卫生标准管理，2015，6（17）：40-41.
[2]	郭元，陈明生，郑冲.帕金森病抑郁的发生率及相关因素分析[J].实用医学杂志，2015，14（16）：2717-2720.
[3]	陈霞，张银玲.帕金森患者抑郁及认知功能情况调查分析[J].齐鲁护理杂志，2013，19（9）：26-27.
[4]	周荣，陈克龙，吴志敏，等.柴胡疏肝散联合度洛西汀治疗帕金森病抑郁临床观察[J].浙江中西医结合杂志，2016，26（1）：50-52.
[5]	中华医学会神经病学分会神经心理学与行为神经病学组.帕金森病抑郁、焦虑及精神病性障碍的诊断标准及治疗
[6]	张熙悫，娄凡，刘娜，等.帕金森病伴发抑郁的研究进展[J].中华临床医师杂志（电子版），2015，9（4）：638-641.
[7]	王波，桂小红，张文颖，等.帕金森病抑郁影响患者健康相关生活质量[J].中华神经科杂志，2013，46（4）：252-253.
[8]	梁普莹，岑慧红，周玉兰，等.帕金森患者抑郁焦虑相关危险因素调查及心理护理对策[J].中国医药指南，2013，11（14）：5-6.
[9]	陈品，邓建中.盐酸文拉法辛联合奥氮平治疗帕金森病合并抑郁、焦虑状态[J].中国实用神经病学杂志，2013，16（12）：13-15.
[10]	董兴鲁，玉敏，曲淼.帕金森病伴发抑郁的流行病学和治疗研究进展[J].现代中医临床，2015，22（1）：56-60.
[11]	胡正祥，卢晓东，程忱.舒肝解郁胶囊联合普拉克索对帕金森病抑郁的治疗效果[J].中国生化药物杂志，2017，37（5）：335-337.
[12]	莫夸耀，陈晓昕，李凌恩，等.度洛西汀治疗抑郁症的疗效及安全性[J].现代医药卫生，2013，29（17）：2654-2655.
[13]	华彩霞，朱满连，周云芳，等.度洛西汀与舍曲林治疗老年抑郁症的疗效和安全性[J].中国临床药理学杂志，2013，29（2）：116-117.
[14]	赵剑华，张静霞，张碧云.解郁胶囊联合盐酸度洛西汀肠溶片治疗抑郁症 48 例[J].中医研究，2016，29（1）：15-17.
[15]	叶建飞，林勇，夏江明.舒肝解郁胶囊与舍曲林治疗老年抑郁症的对照研究[J].中成药，2014，36（5）：1104-1105.