中国当代医药
      Home                              中文
中国当代医药
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2018 Vol. 25, No. 3
Published: 2018-01-28
 
 
4 High performance liquid chromatography method for rapid detection of cholesterol-lowering type of proprietary Chinese medicine illegally added chemicals
TANG Jun;LONG Yu-qiong
ObjectiveTo establish a quick,sensitive method for analysis of Prefvastatin Sodium,Atorvastatin Calcium,Lovastatin and Simvastatin illegally added into cholesterol-lowering type of proprietary Chinese medicine.MethodsAnglient ZORBAX SB-C18(5 μm,4.6 mm×150 mm)column was used,mobile phase consisted of methanol and 0.03 mol/L phosphate(PH to 3.5)(25:75)with flow rate 1.0 ml/min and column temperature at 30℃.The detection wavelength was set at 238 nm.ResultsThe linear equation of Prefvastatin Sodium was Y=2933.12927X+153.32226(r=0.99971),the linear equation of Atorvastatin Calcium was Y=2382.54405X-38.16470(r=0.99998),the linear equation of Lovastatin was Y=2166.75981X+84.99321(r=0.99993),the linear equation of Simvastatin was Y=1784.69863X+147.95365(r=0.99981).The average recoveries(n=6)of Prefvastatin Sodium,Atorvastatin Calcium,Lovastatin and Simvastatin were 103.3%(RSD=0.9%),108.3%(RSD=0.7%),99.6%(RSD=0.6%),95.6%(RSD=0.7%).ConclusionAfter validation,the method was proved to be quick and simple,which can be used to detect illegal additive in cholesterol-lowering type of proprietary Chinese medicine.
2018 Vol. 25 (3): 4-6 [Abstract] ( 217 ) HTML (29 KB)  PDF  (0 KB)  ( 62 )
7 Simultaneous determination of the concentration of Theophylline and Doxofylline in human plasma by revered-phase high performance liquid chromatography
ZHAO Rui-ke;CAO Jun-hua

ObjectiveTo establish a method for simultaneous determination of theophylline and doxofylline in human plasma by RP-HPLC.MethodsPhenomenex C18(250 mm ×4.6 mm,5 μm)column was used.The mobile phase was composed of methanol-water(30∶70)at flow rate of 1.0 ml/min.The detection wavelength was 273 nm and the internal standard was caffeine.ResultsThe linear range was 1.05 to 67.33 μg/ml for theophylline and doxofylline (r＞0.999).The recovery rates was 96.79%-105.40%and 91.85%-95.51%respectively.The intra-day precisions and the inter-day precisions were both less than 10%.ConclusionThe method is rapid and accurate.It can be used for the simultaneous determination of theophylline and doxofylline concentration in human plasma.
2018 Vol. 25 (3): 7-9 [Abstract] ( 221 ) HTML (26 KB)  PDF  (0 KB)  ( 92 )
10 Experimental research on the pharmacological effects of astragalus polysaccharide on immune function in mice
FAN Wen-tong
ObjectiveTo investigate the effect of astragalus polysaccharide in multiple administrations on humoral,cellular,and nonspecific immune function in mice from day 14 to 17.MethodsMale Kunming mice were selected as the subjects,and randomly divided into 8 groups:blank control group(taking into account that the cellulose itself also belongs to polysaccharide,and blank control group was set in order to exclude its impact),normal control group,model group,1000 mg/kg Ganodermalucidum polysaccharide group,and groups of Astragalus polysaccharide in doses of 125 mg/kg,250 mg/kg,500 mg/kg and 1000 mg/kg.There were 12 animals in each group.Each day,8:00 was for fasting,and 14:00 for intragastric administration based on the weight(0.4 ml/20 g).There was no drug or menstruum in the blank control group.In the normal and model groups,same volume of 0.5%CMC was offered.After 2-hour medication,food was provided with 3 g each mouse.The medication was lasted for 15 days.In day 10 of administration,S180 tumor-bearing cells were inoculated to the right axilla in mice except blank and normal control groups.24 hour after medication,blood was collected from eye socket,and serum was separated.The serum was diluted in 3 times to determine the diameter of IgG precipitation ring.By reference of the standard IgG,the relative content of IgG in the sample was calculated.The experimental results were statistically analyzed.ResultsAstragalus polysaccharide in 125,250,500 mg/kg,and 1000 mg/kg could significantly increase the serum IgG content in the immunosuppressive mice induced by cyclophosphamide and tumorbearing.Astragalus polysaccharide in 500 mg/kg and 1000 mg/kg greatly increased the content of serum IgG in irradiated mice.After skin allergy due to exposure to 2,4-dinitrofluorobenzene,the delayed allergic reaction mediated by T cells could be induced by repeated skin contact about one week.Astragalus polysaccharide in 250 mg/kg and 500 mg/kg could increase delayed allergic reaction in normal mice induced by 2,4-dinitrofluorobenzene.If in 125 mg/kg and 500 mg/kg,astragalus polysaccharidecould increase the delayed allergic reaction in immunosuppressive miceinduced by cyclophosphamide which was from 2,4-dinitrofluorobenzene.Astragalus polysaccharide in 250 mg/kg and 500 mg/kg could obviously restore the phagocytic function in immunosuppressive mice induced by cyclophosphamide,and 500 mg/kg could markedly raise the carbon clearance index K and phagocytic index α in mice.ConclusionIt is indicated that thatastragalus polysaccharide has the function of increasing humoral immunity,promotes the function of T-lymphocyte immune cells,and can significantly improve the nonspecific immune function in mice.
2018 Vol. 25 (3): 10-14 [Abstract] ( 202 ) HTML (43 KB)  PDF  (0 KB)  ( 83 )
15 UPLC method in the determination of the content of Vitamin E in plasma
ZHU Jiang;HE Wen-ji;LI Cui-lian;GUO Gui-tang;YANG Guang-neng;ZHANG Zhen
ObjectiveTo establish a rapid and accurate method in the determination of the content of Vitamin E in children′s plasma clinically.Methods200 μl children′s plasma was collected.140 μl methanol and isopropanol were added with the proportion of v/v,8:2,which were vortexed for 30 s.1 ml n-hexane was added and vortexed for 1 min.They were centrifuged at a high speed at room temperature for 120 s(12 000×g).700 μl supernatant was collected after centrifuge,blown dry and redissolved by 100 μl methanol.Chromatographic condition:BEH C18chromatographic column from Waters company was applied (50 mm×2.1 mm,1.7 μm).The prepared solution of 5 μl was taken as a sample,and determined with the flow rate of 0.3 mL/min.Methanol-water(96:4)was the mobile phase.The column temperature was 30℃.Under the condition,the determination wavelength was 291 nm.ResultsThe chromatographic peak of vitamin E in plasma was separated favorably,and non-interference linear regression equation was y=118296x+11644,r2=0.9997.The recovery rate was 90%-120%.ConclusionThe method is simple to operate,which is suitable for the rapid determination of Vitamin E content in children′s plasma.
2018 Vol. 25 (3): 15-17 [Abstract] ( 185 ) HTML (27 KB)  PDF  (0 KB)  ( 108 )
18 Research progress of elastography technology on donor evaluation of liver transplantation
YANG Wan-dong;XIAO Chun-hua;CHEN Xiao;PU Hui-min
Liver transplantation is the most effective method for end-stage liver disease,and the quality of donor is crucial to the success of the operation.CT,MRI and conventional ultrasound can assess the donor status,but have limitations.Elastography is a new method of noninvasive detection of tissue hardness,which can monitor the elastic hardness of the liver,and is widely used in the evaluation of liver diseases and liver transplantation.In this paper,the imaging evaluation methods of liver transplantation and the development of elastography,the application of liver lesions and liver transplantation were reviewed,and highlight its advantages of assessment of donor quality in liver transplantation and prospect of application.
2018 Vol. 25 (3): 18-20 [Abstract] ( 179 ) HTML (26 KB)  PDF  (0 KB)  ( 84 )
21 Research progress of relationship between functional dyspepsia and gastric mucosalmast cells
JIA Bao-hui;LI Xiao-li
The pathogenic factors and pathogenesis of functional dyspepsia (FD)are diverse and unelucidated.At present,it is believed that it is related to gastrointestinal motility disorders,visceralhypersensitivity,infection of H.pylori and psychological dysfunction.Numerous studies have proved that mast cell(MC)as an immune cell may participate in the pathophysiological process of FD.The aim of this dissertation is to review the relationship between FD and MC through the above aspects.
2018 Vol. 25 (3): 21-23 [Abstract] ( 175 ) HTML (25 KB)  PDF  (0 KB)  ( 72 )
24 Study on postoperative infection of laparoscopic cholecystectomy for acute cholecystitis complicated with biliary peritonitis
ZHOU Xiao-long; ZENG Xian-min
ObjectiveTo compare the effects of laparoscopic cholecystectomy(LC)and traditional open cholecystectomy(OC)on immune response and systemic inflammation in patients with acute cholecystitis complicated with biliary peritonitis.MethodsFrom November 2015 to November 2016,100 cases of acute cholecystitis patients were complicated with bile peritonitis,were randomly divided into two groups according to the random number table method,50 cases in each group.The patients of the observation group were used laparoscopic cholecystectomy treatment.The patients of the control group were used the traditional open cholecystectomy treatment.The postoperative complications,length of stay and death were observed and compared between the two groups.The changes of neutrophil,IL-6 red cell sedimentation rate (ESR)and serum CRP level were compared between the two groups.ResultsThe hospital stay in the observation group ([5.3±2.6]d)was compared to the control group([10.1±3.4]d),significantly less than the latter(P＜0.05）;the patients in the observation group the incidence of abdominal abscess(6%),the mortality rate(4%)were both lower than in the control group(36%,28%)(P＜0.05）.At first,third and 6 days after operation,the levels of neutrophils,serum CRP,ESR and IL-6 in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).ConclusionCompared with OC，LC can reduce the level of systemic inflammatory response，promote the construction of transient immune defense，and can minimize the risk of postoperative infection,and has high clinical application value.
2018 Vol. 25 (3): 24-26 [Abstract] ( 201 ) HTML (25 KB)  PDF  (0 KB)  ( 75 )
27 Comparison of the effects of intracapsular injection of Triamcinolone acetonide and incision and drainage in treatment of pseudocyst of auricle
HE Li-xing;XU Jin-hua;WU Lu-jing;JIANG Wan-fu;LU Hua;WANG De-xiong
ObjectiveTo investigate the clinical effect of intracapsular injection of Cu Ann Ned and incision and drainage in the treatment of pseudocyst of auricle.Methods100 cases of pseudocyst of auricle treated in our hospital from February 2014 to December 2016 were selected and randomly divided into control group and study group according to the random number table method,50 cases in the control group were treated with incision and drainage,and 50 cases in the study group were treated with intracapsular injection of Triamcinolone acetonide.After 30 days treatment,the patients relapsed and underwent two treatment.The clinical efficiency of the first treatment and the two treatment were recorded,and the clinical effects,recurrence,patient satisfaction and adverse reactions were compared between the two groups after 6 months of treatment.ResultsThe total effective rate(92.00%)of the study group after two treatment was significantly higher than that of the first treatment(76.00%)(P＜0.05).After 6 months,the total effective rate(92.00%)of the study group was significantly higher than that of the control group (72.00%)(P＜0.05),and the recurrence rate of the study group (4.00%)was significantly lower than that of the control group (30.00%).The total satisfaction degree of the patients in the study group(92.00%)was significantly higher than that of the control group(78.00%)(P＜0.05).The incidence of adverse events in the study group (4.00%)was not significantly different from the control group (8.00%)(P＞0.05).ConclusionIntracapsular injection application of Triamcinolone acetonide in auricle pseudocyst patients compared with incision and drainage treatment,clinical curative effect is high,the recurrence rate is low,a high degree of satisfaction,has certain safety,it is worth popularizing in clinical use.
2018 Vol. 25 (3): 27-29 [Abstract] ( 184 ) HTML (28 KB)  PDF  (0 KB)  ( 38 )
30 Effect of emergency laparoscopic minimally invasive surgery treatment perforation of gastroduodenal ulcer
JIANG Yi-yang; TAN Ying-sheng ;WU De-ai
ObjectiveTo explore the clinical effect of minimally invasive laparoscopic minimally invasive surgery in the treatment of gastroduodenal ulcer perforation.Methods92 patients with acute gastroduodenal ulcer who were treated in our hoptipal from October 2009 to September 2017 were retrospectively analyzed,and they were divided into observation group and control group(n=46)according to different treatments.The patients in the control group were treated with traditional laparotomy.The patients in the observation group were treated with minimally invasive laparoscopic minimally invasive surgery.The operation time,intraoperative blood loss,anal exhaust time and hospitalization time were compared between the two groups,and the postoperative complications were compared between the two groups.ResultsThe operation time of observation group was longer than that of the control group(P＜0.05);intraoperative blood loss in the observation group was lesser than that in the control group(P＜0.05);the observation group anal exhaust time,hospitalization time was shorter than that in the control group (P＜0.05);observation group patients with complication rate was 2.2%（1/46）,significantly lower than the control group 10.9%（5/46）,the differences were statistically significant(P＜0.05).ConclusionLaparoscopic minimally invasive surgery for the treatment of gastroduodenal ulcer perforation is effective，can effectively reduce the surgical injury,accelerate the rehabilitation of patients after surgery,while reducing the incidence of complications,worthy of clinical promotion and application.
2018 Vol. 25 (3): 30-32 [Abstract] ( 187 ) HTML (27 KB)  PDF  (0 KB)  ( 93 )
33 Application of multifunctional rectal catheterization in the treatment of abdominal compartment syndrome
LIN Mei-zhen
ObjectiveTo study the application effect of multifunctional rectal catheterization in the treatment of patients with abdominal compartment syndrome(ACS).MethodsFrom January 2014 to January 2017,25 patients with ACS treated in our hospital were selected as research objects.All participants were performed with multifunctional rectal catheterization for abdominal decompression.The therapeutic effect was statistically analyzed and the difference of intra-abdominal pressure(IAP)before and after treatment was compared.ResultsThe level of IAP before treatment was(25.4±2.2)mmHg,and(19.4±2.3)mmHg after therapy.The descending amplitude was (5.4±1.6)mmHg compared with prior treatment,which was displayed statistical significance(P＜0.05).Among all these participants,5 cases were in death,and the mortality rate was 20.0%.To be specific,2 patients with severe abdominal trauma were dead due to several serious complications.One patient with craniocerebral injury died because of invalid rescue during operation.The fourth case suffered from suppurative obstructive cholangitis was also due to invalid rescue during surgery.The last one diagnosed as endometrial cancer died due to cachexy state combined with abdominal compartment syndrome.ConclusionApplication of multifunctional rectal catheterization can obtain a favorable effect in patients with ACS and effectively improve the continuous increase of IAP which is worthy of clinical promotion.
2018 Vol. 25 (3): 33-35 [Abstract] ( 170 ) HTML (24 KB)  PDF  (0 KB)  ( 87 )
36 Efficacy and safety analysis of medium-wave high-energy ultraviolet irradiation combined with 0.03%Tacrolimus Ointment in the treatment of children with vitiligo
LIANG Xing-long ;YAN Jun; FENG Fan
ObjectiveTo observe the safety of medium-wave high-energy ultraviolet irradiation combined with 0.03%Tacrolimus Ointment in the treatment of vitiligo in children and the analysis of its influencing factors.MethodsA total of 120 patients diagnosed as pediatric vitiligo treated in our hospital from March 2014 to March 2017 were selected as research objects.Their clinical data were collected and analyzed retrospectively.According to the different therapeutic regimen,they were divided into the observation group,control group 1,and control group 2 evenly.In the observation group,40 cases were treated with medium-wave high-energy ultraviolet irradiation combined with 0.03%Tacrolimus Ointment,1 to 2 times per week,12 weeks for one course of treatment.In the control group 1,only ultraviolet radiation was used,and in the control group 2,only external application of Tacrolimus Ointment was adopted.The therapeutic effect,influencing factors,and safety among the three groups were analyzed.ResultsIn the observation group,the total effectiveness rate was 67.50%(27/40),significantly higher than that of control group 1 accounting for 50.00%(20/40),and control group 2 accounting for 42.5%(17/40),the difference was statistically significant(P＜0.05).There was no significant difference between the control group 1 and control group 2 (P＞0.05).The onset time of color restoration of skin lesions in the observation group was (1.52±0.66)months,greatly lower than that in the control group 1 and control group 2,(1.90±0.95)months and(1.95±0.90)months(P＜0.05),but there was no significant difference between the last two groups(P＞0.05).The effectiveness rates of the head and face,the trunk,four limbs,and the end of extremities were all higher than those in the control group 1 and control group 2,but no statistical difference was detected when comparing the data between the control groups(P＞0.05).The incidence of adverse reaction for the first time in the observation group was 45.00%,which was the same as that in the control group 1,but slightly higher than that in control group 2 accounting for 40.00%.There was no significant difference between control groups (P＞0.05).Conclusion In the treatment of children with vitiligo,application of medium-wave high-energy ultraviolet irradiation combined with 0.03%Tacrolimus Ointment can obtain a favorable effect in mild side effect and high safety and the therapeutic effects are mainly influenced by the affected site,course of disease，and treatment frequency,and is worthy of clinical promotion.
2018 Vol. 25 (3): 36-38 [Abstract] ( 205 ) HTML (28 KB)  PDF  (0 KB)  ( 72 )
39 Observation on the clinical efficacy of Budesonide Formoterol Inhalant in the treatment of chronic obstructive pulmonary disease
FAN Yan-ni;SUN Xiao-qin
ObjectiveTo investigate the clinical efficacy of Budesonide Formoterol Inhalant in the treatment of chronic obstructive pulmonary disease.MethodsA total of 120 patients with chronic obstructive pulmonary disease treated in our hospital from August 2015 to August 2017 were selected as the research subjects.The patients were divided into experimental group and control group on the basis of random digital table method,with 60 cases in each group.The control group was given conventional treatment,and the experimental group was supplemented with Budesonide Formoterol Inhalant on the basis of routine treatment.The cycle of treatment was 8 weeks in both groups.The lung function,6-WMD,and the incidence rate of adverse reactions during the treatment were compared between the two groups before and after treatment.The quality of life before and after treatment was evaluated using the St.George′s Respiratory Disease Questionnaire (SGRQ)scale and CAT questionnaire.ResultsCompared with those before treatment,FEV1,FEV1pred%,and FEV1/FVC in the experimental group were decreased,and 6-WMD,SGRQ score and CAT score were improved.Compared with those before treatment,FEV1,FEV1pred%,FEV1/FVC,6-WMD,SGRQ scores and CAT scores in the control group were not significantly different,and the differences were not statistically significant(P＞0.05).After treatment,FEV1,FEV1pred%,FEV1/FVC,6-WMD,SGRQ and CAT scores in the experimental group were significantly better than those in the control group,the differences were statistically significant(P＜0.05).ConclusionBudesonide Formoterol Inhalant can effectively relieve the clinical symptoms of patients with chronic obstructive pulmonary disease,improve lung function and improve the quality of life,which is worthy of clinical promotion and application.
2018 Vol. 25 (3): 39-41转44 [Abstract] ( 191 ) HTML (30 KB)  PDF  (0 KB)  ( 76 )
42 Effect of high flux hemodialysis on nutritional status of elderly maintenance hemodialysis patients
MIAO Hui;LIU Fang; LIU Xi;SHEN Ming-jing
ObjectiveTo investigate the effect of high flux hemodialysis(HFHD)on nutritional status of elderly patients with maintenance hemodialysis(MHD).Methods58 cases of elderly patients with MHD in the hemodialysis room in our hospital as the research object,randomly divided into two groups according to random number table method,29 cases in each group.The control group was treated with conventional low flux hemodialysis (CHD)treatment,the observation group received HFHD treatment,serum hs-CRP,ALB and PAB levels and MQSGA score of two groups were compared before and after treatment.ResultsAfter treatment,the serum hs-CRP,ALB,PAB and MQSGA score in control group compared with before treatment was of no statistically significant difference (P＞0.05).The serum hs-CRP and MQSGA score decreased significantly in the observation group,serum ALB and PAB increased significantly and compared with the control group,the differences were of statistically significant(P＜0.05).ConclusionHFHD can effectively inhibit the micro inflammatory reaction and improve the nutritional status in elderly patients with maintenance hemodialysis.
2018 Vol. 25 (3): 42-44 [Abstract] ( 181 ) HTML (23 KB)  PDF  (0 KB)  ( 41 )
45 Influence of Ozone on the untoward effect related to ischemia reperfusion after angioplasty of lower extremity atheroselerotic disease
TAN Zhi-bin;ZHONG Li-qing;LIN Ji-ping;ZHANG Zhi-cheng;XIAO Yi-ming;TANG Cheng-fu

ObjectiveTo investigate the influence of ozone major autohemotherapy(O-MAHT)on untoward effect related to ischemia reperfusion after angioplasty of lower extremity.Methods75 cases of LEAD patients who had successful endovascular therapy in our hospital from August 2015 to May 2017 were selected as research subjects and divided into 3 groups,25 cases in each group.The patients were treated with O-MAHT three days after angioplasty were included into group A were patients were treated with O-MAHT 12 hours after angioplasty were included into group B;and those had no O-MAHT therapy before and after angioplasty were included into group C.The untoward effect of patients in these three groups after angioplasty was observed and recorded.ResultsThe occurrence rate of untoward effect of patients in group A,group B and group C was 60.0%,64.0%and 88.0%respectively.The group comparison between group A and B regarding the occurrence rate of untoward effect had no statistical difference(P＞0.05);and that between group A and C,group B and C had statistical difference (P＜0.05).ConclusionApplying O-MAHT to patients who had angioplasty of lower extremity atheroselerotic disease before angioplasty and at the early period of postoperation could protect the lower extremity and reduce the untoward effect due to ischemia reperfusion.
2018 Vol. 25 (3): 45-47 [Abstract] ( 174 ) HTML (25 KB)  PDF  (0 KB)  ( 87 )
48 Clinical effect of noninvasive ventilation as an adjuvant therapy in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure
ZHANG Guo-liang; JIANG Lan
ObjectiveTo investigate the clinical effect of noninvasive ventilation （NIV）as an adjuvant therapy in the treatment of chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.MethodsFrom May 2015 to May 2017,96 patients with COPD complicated with respiratory failure in our hospital were enrolled and evenly divided into the observation group(n=48)and the control group(n=48)by the random number table method.In the control group,traditional ventilation via nasal catheter as an adjuvant therapy was used,while in the observation group,NIV was applied.The heart rate(HR),respiratory rate(RR),PaO2level,and clinical effect were compared before and after therapy.ResultsThere was no significant difference in HR,RR,or PaO2between the two groups before treatment(P＞0.05).After treatment,in the observation group,the HR and RR were(23.91±1.49)times/min and(97.20±2.54)times/min,which were greatly lower than those in the control group(29.35±2.43)times/min and(116.32±2.61)times/min(P＜0.05).The PaO2level in the observation group was (83.62±11.23)mmHg,higher than that in the control group(64.35±9.17)mmHg,the differences were statistically significant (P＜0.05).The therapeutic effectiveness rate in the observation group was 93.75%,superior to that in the control group accounting for 75.00%,the difference was statistically significant(P＜0.05).ConclusionNIV as an adjuvant therapy in the treatment of COPD complicated with respiratory failure can effectively improve the patient′s condition,promote the recovery of respiratory function.The effect is remarkable,and is worthy of promotion.
2018 Vol. 25 (3): 48-50 [Abstract] ( 158 ) HTML (25 KB)  PDF  (0 KB)  ( 110 )
51 Observe the clinical effect of Xingnaojing Injection in the treatment of severe craniocerebral injury
GUAN Yuan-zhi
ObjectiveTo observe the clinical effect of treatment with Xingnaojing Injection on patients with severe craniocerebral injury.Methods90 patients with severe craniocerebral injury who were treated in our hospital from January 2016 to October 2017 were randomly divided into two groups according to random number table method.45 cases in the control group were treated by conventional therapy.45 cases in the study group were treated with Xingnaojing Injection，compared two groups of related clinical indicators data changes.ResultsThe Glasgow Coma Scale （GCS） score in the latter half month and one month after treatment in the study group was significantly higher than that in the control group，the difference was statistically significant（P＜0.05）.There was no significant difference in GCS score between three days and one week after treatment （P＞0.05）.The total effective rate and awake rate of clinical treatment in the study group were higher than those in the control group，the awake time was shorter than that in the control group，the incidence of complications and mortality were lower than the control group，the differences were statistically significant （P＜0.05）.ConclusionClinical treatment of patients with severe craniocerebral injury in the conventional treatment based on the use of Xingnaojing Injection for treatment，which can effectively control the patient′s condition，improve clinical outcomes and reduce the rate of adverse clinical reactions in patients with high safety，which will help shorten the patients Awake time to promote their physical recovery，it is worthy of clinical application.
2018 Vol. 25 (3): 51-53 [Abstract] ( 162 ) HTML (28 KB)  PDF  (0 KB)  ( 70 )
54 Application effect of different drugs in the anaesthesia of transvaginal puncture and ovum extraction
HU Shuai
ObjectiveTo explore the application effect of different drugs in the anaesthesia of transvaginal puncture and ovum extraction.Methods50 patients received the transvaginal puncture and ovum extraction from August 1,2015 to July 31,2017 were selected as object.Using the computer random grouping method,50 patients were divided into the two groups,and there were 25 cases in each group.The observation group was treated with Dexmedetomidine+Diazepam,while the control group was treated with Remifentanil+Propofol.Various signs of life and incidence of adverse reaction between the two groups were compared.ResultsThe respiratory frequency,oxygen saturation,heart rate and mean arterial pressure of the patients in the observation group were not significantly changed at T1,T2,T3,T4and T5(P＞0.05).The respiratory rate and oxygen saturation at T2,T3,T4and T5in the observation group were higher than those in the control group and the heart rate and mean arterial pressure at T2in the observation group were higher than those in the control group,and the heart rate and mean arterial pressure at T5were lower than those in the control group,with a statistically significant difference(P＜0.05).The incidence of postoperative restlessness and oxygen saturation ＜92%was lower in the observation group than in the control group,and the difference was statistically significant(P＜0.05).ConclusionThe effect of Dexmedetomidine combined with Diazepam applied in the transvaginal puncture and ovum extraction is reliable.
2018 Vol. 25 (3): 54-56 [Abstract] ( 142 ) HTML (27 KB)  PDF  (0 KB)  ( 80 )
57 Value analysis of Narcotrend monitoring in general anesthesia of pediatric patients
HUANG Mei
ObjectiveTo investigate the value of Narcotrend monitoring in general anesthesia of pediatric patients.Methods92 children undergoing general anesthesia operation treated in our hospital were selected from March 2016 to March 2017.All children were treated with Propofol-Seven Halothane inhalation combined with general anesthesia.Using random number method method,all children were divided into the observation group and control group,and each group had 46 cases.The concentration of Propofol and Seven Halothane in the observation group were adjusted according to Narcotrend while Propofol and Seven Halothane concentration in the control group were regulated according to the blood pressure,heart rate,and other vital signs and the experience of the anesthesiologist.The recovery time,extubation time,dosage of Propofol and Seven Halothane were compared in pediatric patients between the two groups,and the incidence of adverse reactions such as cough,nausea and vomiting and postoperative agitation in pediatric children were observed.ResultsThe recovery time and extubation time in the observation group were significantly shorter than those in the control group (P＜0.05).The dosage of Propofol and Seven Halothane in the observation group was significantly fewer than those of the control group (P＜0.05).The total incidence of adverse reactions in the observation group was 8.70%,which was significantly lower than that in the control group(28.26%)(P＜0.05).ConclusionNarcotrend anesthesia depth monitoring of anesthesia in pediatric patients has fewer narcotic drugs consumption,recovery time and extubation time are short with fewer adverse reactions,and it is a simple,efficient and practical depth of anesthesia detection method.It is worthy of clinical promotion.
2018 Vol. 25 (3): 57-59 [Abstract] ( 180 ) HTML (25 KB)  PDF  (0 KB)  ( 97 )
60 The influence of Lidocaine on the perioperative stress reaction and immunologic function in patients undergoing cervical lymph node tuberculosis resection
ZHOU Tian-tian;CHEN Zi-yang;YU Shu-xia;ZHANG Shao-gang
ObjectiveTo observe the influence of Lidocaine on the perioperative stress response and immunologic function in patients undergoing cervical lymph node tuberculosis resection.MethodsSixty patients scheduled for cervical lymph node tuberculosis resection from August 2016 to June 2017 in our hospital were selected.The patients were divided into Lidocaine group(group L)and control group(group C)according to the random number table method,and there were 30 patients in each group.Group L was administered 1.5 mg/kg bolus dose of Lidocaine before 10 min tracheal intubation,followed by 1.5 mg/（kg·h） infusion until the end of operation while group C was continuously pumped the equal capacity of normal saline.MAP,HR were recorded before 30 min anesthesia induction(T0),after 1 h operation initiation(T1),immediately after operation(T2),after 6 h operation(T3).Enzyme-linked immunosorbent assay was used to detect norepinephrine (NE),epinephrine (E),cortisol(Cor)at T0-T3.Flow cytometry was used to detect T lymphocytes(CD3+,CD4+,CD8+,CD4+/CD8+)and NK cells at T0-T3.ResultsCompared to those at T0,MAP,HR and stress hormones(NE,E,Cor)in both groups were significantly increased at T1-T3(P＜0.05),which was more significant in group C than that of group L(P＜0.05).The level of CD3+,CD4+,CD8+,CD4+/CD8+at T1-T3were significantly lower in both groups,and the levels in group C were obviously lower than those in group L(P＜0.05).The level of NK cells was higher at T1-T3in both groups,the level in group L was obviously higher than those in group C(P＜0.05).ConclusionIntravenous infusion of Lidocaine can suppress perioperative stress reaction effectively and reduce the influence on immunologic function of cell.
2018 Vol. 25 (3): 60-62转66 [Abstract] ( 166 ) HTML (34 KB)  PDF  (0 KB)  ( 101 )
63 Clinical study of transversus abdominis plane block applied in the postoperative analgesia of abdominal surgery
HU Xiao-dong; LI Kun;ZHANG Hai-bo;ZHANG Xiao-lin
ObjectiveTo study the clinical effect of transverse abdominal plane (TAP)block applied in the postoperative analgesia of abdominal surgery.MethodsFrom January 2015 to April 2017,98 patients undergoing abdominal surgery admitted into our hospital were selected and they were divided into the two groups according to the random number table method,and there were 49 patients in each group.TAP block was performed in both groups.The control group was given normal saline,and the experimental group was given Ropivacaine.The pain score (VAS score),sedation degree(Ramsay score),comfort degree(BCS score),incidence rate of adverse reactions,and the useage of analgesic pump(drug use dose of 24 h analgesic pump,the duration from the first demand of analgesic pump to awakening and extubation,actual press times of analgesic pump,valid press times of analgesic pump,and the total effective rate of 24 h press)were compared between the two groups.ResultsAfter 0.5 h,2 h,6 h,12 h and 24 h,VAS score in the experimental group was lower than that in the control group,and Ramsay and BCS score were higher than those in the control group,and the difference was statistically significant(P＜0.05).There was no statistical difference of the total incidence of adverse reactions between the two groups(P＞0.05).The drug use dose of 24 h analgesic pump,actual press times of analgesic pump and valid press times of analgesic pump in the experimental group were fewer than those in the control group,the duration from the first demand of analgesic pump to awakening and extubation time in the experimental group was longer than that of the control group,and the total effective rate of 24 h press in the experimental group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion TAP block can reduce postoperative pain degree after abdominal surgery,improve the comfort degree and sedation effect,and has a higher safety.
2018 Vol. 25 (3): 63-66 [Abstract] ( 176 ) HTML (30 KB)  PDF  (0 KB)  ( 52 )
67 Influence of Sufentanil and Fentanyl used for anaesthesia on hemodynamics in elderly patients with laparoscopic cholecystectomy
LIU Rong-wei
ObjectiveTo observe the influence of Sufentanil and Fentanyl used for anaesthesia on hemodynamics in elderly patients with laparoscopic cholecystectomy.Methods156 elderly patients with gradeⅠ-Ⅱ of ASA and scheduled for laparoscopic cholecystectomy in our hospital from April 2016 to August 2017 were selected as object and they were randomly divided into the Sufentanil group and Fentanyl group according to the random number table method,and there were 78 cases in each group.The Fentanyl group was combined with Fentanyl for anesthesia induction and maintenance,and Sufentanil was used in the Sufentanil group.The change of HR,SBP and DBP before anesthesia induction(T0),after induction(T1),intubation(T2)and after extubation(T3)in patients between the two groups were compared.At the same time,the revival situation and the incidence of adverse reactions in patients between the two groups were compared.ResultsHR,SBP and DBP at T1were significantly lower than those at T0in the two groups,and the abovementioned-indexes at T2and T3were significantly higher than those at T0(P＜0.05).HR,SBP and DBP at T1in the Sufentanil were significantly higher than those in the Fentanyl group,and HR,SBP and DBP at T2,T3in the Sufentanil were significantly lower than those in the Fentanyl group (P＜0.05).Time required for anaesthesia recovery,spontaneous breathing recovery and extubation in patients of the Sufentanil group were significantly shorter than those of the Fentanyl group (P＜0.01).The total incidence of respiratory depression,gastrointestinal reaction,irritability and arrhythmia and so on in the Sufentanil group was significantly lower than that of the Fentanyl group (P＜0.05).ConclusionIn the induction and maintenance of anesthesia for elderly patients with laparoscopic cholecystectomy,Fentanyl and Sufentanil can influence the hemodynamics of patients,but compared with Fentanyl,Sufentanil in maintaining the hemodynamic stability has a more prominent role,at the same time,it can also promote the recovery of patients after anesthesia with fewer adverse reactions,it is worthy of clinical promotion and application.
2018 Vol. 25 (3): 67-69转72 [Abstract] ( 159 ) HTML (31 KB)  PDF  (0 KB)  ( 89 )
70 Anesthetic effect comparision of intravenous inhalational anesthesia and totalintravenousanesthesiainpatientswithgynecologiclaparoscopicsurgery
HE Jun-yong; ZHONG Xiang-peng; LI Zhi-chao; WANG Song; LIU Yong
ObjectiveTo compare the anesthetic effect of intravenous inhalational anesthesia and total intravenous anesthesia in patients with gynecologic laparoscopic surgery to provide the clinical guidance on the selection of the anesthesia methods of gynecologic laparoscopic surgery.Methods90 patients receiving the gynecological laparoscopic surgery treated in our hospital from September 2015 to September 2017 were selected and they were randomly divided into the control group (n=45)and experimental group (n=45).Patients in the control group were given intravenous inhalational anesthesia,while patients the experimental group were given total intravenous anesthesia.The anesthetic effect,hemodynamics indexes and the incidence of adverse reaction after operation were compared in patients between the two groups.ResultsThe onset time of anesthesia,opening time and extubation time in the experimental group were significantly shorter than those of the control group (P＜0.05).The hemodynamics index of SBP,DBP and heart rate and son on in the experimental group were significantly better than those of the control group (P＜0.05).The total incidence of postoperative adverse reactions in the experimental group was significantly lower than that in the control group (P＜0.05).ConclusionCompared with the intravenous inhalational anesthesia,the total intravenous anesthesia has an more ideal anesthetic effect in patients with gynecologic laparoscopic surgery,and the hemodynamics index is more stable,the safety is higher.It is worthy of clinical promotion and application.
2018 Vol. 25 (3): 70-72 [Abstract] ( 192 ) HTML (26 KB)  PDF  (0 KB)  ( 73 )
73 Comparison of clinical diagnosis between DR and spiral CT in emergency treatment of thoracoabdominal trauma
SUN Ji
ObjectiveTo compare the clinical value of DR and spiral CT in emergency treatment of thoracoabdominal trauma.Methods120 emergency patients with thoracoabdominal trauma admitted from October 2015 to November 2017 in our hospital were selected.All patients were given DR and spiral CT examination.The imaging quality of the two diagnostic methods was analyzed,and the diagnostic coincidence rates of the two diagnostic methods were compared.ResultsThe quality of CT imaging was significantly higher than that of DR(P＜0.05).The coincidence rate of CT in diagnosis of rib fracture,diaphragmatic injury,kidney injury,spleen injury,pancreatic injury,pulmonary contusion,atelectasis,pneumothorax,hematoma and emphysema was as high as 100.00%,significantly higher than that of DR diagnosis of 84.17%,the difference was statistically significant(P＜0.05).ConclusionCompared with DR,the diagnostic value of CT in emergency treatment of chest and abdomen trauma is higher,and it can be used to accurately locate and evaluate the trauma site,which is of great promotion value.
2018 Vol. 25 (3): 73-75 [Abstract] ( 160 ) HTML (25 KB)  PDF  (0 KB)  ( 53 )
76 CT and MRI imaging features and differential diagnosis of IgG4-associated cholangitis
LIUFU Yan-yu
ObjectiveTo investigate the CT and MRI imaging features and differential diagnosis of IgG4-associated cholangitis(IAC).MethodsAltogether 15 patients who were confirmedly diagnosed as IAC in our hospital from January 2014 to June 2017 were selected as the subjects.The research was underwent CT plain scan and enhanced scan,MRI scan and enhanced scan as well as Magnetic Resonance Cholangiopancreatography (MRCP)examination.Statistical analysis of the examination results was made and all the patients received hormone therapy after examinations.Patients were followed up via telephone and outpatient.And the imaging data were evaluated.ResultsOf the 15 patients,10 patients received CT plain scan and enhanced scan,8 patients received MRI plain scan and enhanced scan,and 10 patients received MRCP examination.CT scan showed obvious thickening of the pancreatic duct wall of extrahepatic bile duct.Eccentric thickening of the bile duct wall in the upper part of the pancreas was also showed in some patients with progressive enhancement in bile duct wall.MRCP examination showed extrahepatic biliary pancreatic stricture,intrahepatic bile duct stricture and extrahepatic bile duct stricture were shown in a few patients.The follow-up results showed that 8 patients did not receive steroid treatment,and 3 patients had recurrent bile duct lesions after treatment,resulting in aggravation of the disease.In the rest of the patients,the lesions of the bile duct were obviously improved after steroid treatment.ConclusionThe imaging features of CT and MRI in patients with IgG4-associated cholangitis have obvious characteristics,which can provide reliable references for clinical diagnosis and differential diagnosis,it deserves attention.
2018 Vol. 25 (3): 76-78 [Abstract] ( 195 ) HTML (25 KB)  PDF  (0 KB)  ( 72 )
79 Evaluation of diagnostic value of simple transabdominal ultrasonography and combined transvaginal ultrasonography in adenomyosis
CAO Xiang-xi;LIU Fen
ObjectiveTo study and analysis of simply by abdominal ultrasound examination and combined value of transvaginal ultrasonography in the diagnosis of adenomyosis.Methods100 cases of patients with adenomyosis confirmed by pathology treated in our hospital from January 2016 to September 2017 were selected as the subjects,and randomly divided into control group and observation group by computers,50 cases in each group.The control group adopted simply by abdominal ultrasound examination,the observation group based on the combined transvaginal ultrasound.The diagnosis results and pathological results of the two groups were compared.ResultsCompared with the pathologic results,46 cases were diagnosed in the observation group,4 cases of misdiagnosis,the diagnosis rate was 92.0%(46/50).37 cases were diagnosed in the control group,13 cases of misdiagnosis,the diagnosis coincidence rate was 74%(37/50),the observation group was significantly higher compared with the control group,the difference was statistically significant(P＜0.05).The observation group measured blood flow to the uterus artery,pulsatility index,arterial resistance index (73.24±16.32)ml/min,1.24±0.12,2.85±0.82,the control group were (106.85±16.77)ml/min,0.73±0.16,1.13±0.82,the observation group compared with the control group,the difference was statistically significant(P＜0.05).ConclusionThe combination of transvaginal ultrasonography in diagnosis of adenomyosis is significantly higher than that of simply by abdominal ultrasound examination,the former can improve the diagnosis rate,so as to provide a reliable reference for the treatment of the disease,which is worthy of clinical application.
2018 Vol. 25 (3): 79-81 [Abstract] ( 163 ) HTML (25 KB)  PDF  (0 KB)  ( 70 )
82 Analysis on the application value of color Doppler ultrasound and contrast-enhanced ultrasound in differential diagnosis of ovarian tumors
WANG Li-rong
ObjectiveTo study the application value of color Doppler ultrasound and contrast-enhanced ultrasound in the differential diagnosis of ovarian tumors.MethodsFrom January 1,2016 to September 20,2017,100 patients with ovarian tumor confirmed by pathological examinations and treated in our hospital were enrolled as research objects.They were all examined by color Doppler ultrasound and contrast-enhanced ultrasound successively.The sensitivity,specificity,and accuracy of the two methods were compared.Besides,the parameters of contrast-enhanced ultrasound on benign or malignant tumors were observed and compared.ResultsThe sensitivity (96.00%),specificity (92.00%)and accuracy(94.00%)of contrast-enhanced ultrasound in detection of patients with ovarian tumors were higher than those of color Doppler ultrasound,the difference was statistically significant(P＜0.05).In Contrast-enhanced ultrasound,the initial increase time,peak time and perfusion intensity of benign ovarian tumors were(25.73±2.31)s,(27.92±5.18)s,and(6.05±3.29)dB,which were displayed statistical differences compared with those in malignant lesions(P＜0.05).ConclusionIn the differential diagnosis of ovarian tumors,contrast-enhanced ultrasound has high sensitivity and accuracy,and the clinical value is more important than color Doppler ultrasound.
2018 Vol. 25 (3): 82-84 [Abstract] ( 191 ) HTML (24 KB)  PDF  (0 KB)  ( 77 )
85 Value analysis of ultrasonography in the diagnosis of different pathological types of appendicitis
WU Wei-ke;ZHANG You-hong
ObjectiveTo study the value of ultrasonography in the diagnosis of different pathological types of appendicitis.MethodsFrom January to December in 2016,100 appendicitis patients treated in our hospital were selected as the subjects,recruited and received ultrasonography,consisting of 30 simple appendicitis,25 acute gangrenous appendicitis,15 chronic appendicitis,and 30 acute episode of chronic appendicitis.The length,width,and thickness of the wall of the appendix were preoperatively measured by ultrasonic examination,and the characteristics of the ultrasonic examinations among different types of appendicitis were ascertained by inter-group comparisons.ResultsA total of 83 patients were diagnosed with appendicitis.The success rate of ultrasound diagnosis accounted for 83%.There was no statistical difference in the length of appendix among different types of appendicitis using ultrasonography before surgery(P＞0.05).The preoperative width of appendix in the acute gangrenous appendicitis was wider than that in the acute simple appendicitis and chronic appendicitis.In addition,there was no significant difference displayed in lymph node enlargerment or masses accompanied in the inner side of lumen in different types of appendicitis (P＞0.05).As for indistinct layers of the tube wall and lumen expansion,there were statistical differences in the ultrasonographic images in three types of appendicitis(P＞0.05).ConclusionThe use of ultrasound in the detection of the pathological types of appendicitis has a strong diagnostic value.The width of the appendix is important for the identification of acute gangrenous appendicitis and acute simple appendicitis,but the detected value of ultrasound for acute gangrenous appendicitis,acute simple appendicitis,and chronic appendicitis is very limited.
2018 Vol. 25 (3): 85-87 [Abstract] ( 152 ) HTML (26 KB)  PDF  (0 KB)  ( 83 )
88 Study on the value of CT in the diagnosis and staging of colon cancer
LI Mu-zi
ObjectiveTo study the value of MSCT in the diagnosis and staging of colon cancer before operation.MethodsA total of 1,000 patients with colon cancer were enrolled in our hospital from January 2015 to March 2017.The staging results of CT imaging and the staging of pathology were analyzed and compared.The MSCT was performed on colon cancer,and the accuracy of preoperative diagnosis was analyzed.ResultsThe accuracy index of colon cancer staging using MSCT was the following four aspects.The accuracy of T staging results was 91.9%,the accuracy of N index was 88.5%,and the accuracy of M was 98.2%.The index accuracy of TMN was 71.3%.After correlation analysis and comparison of the accuracy in colorectal cancer and the results of postoperative cases,the results showed that the diagnostic accuracy of MSCT was better,without significant difference(P＞0.05).ConclusionMultislice spiral CT has a greater clinical value on the preoperative diagnosis and staging of colon cancer,which is worthy of clinical use.
2018 Vol. 25 (3): 88-90 [Abstract] ( 171 ) HTML (26 KB)  PDF  (0 KB)  ( 74 )
91 Therapeutic effect of Acarbose combined with Tongxinluo Capsules in coronary heart disease patients with impaired glucose tolerance
LI Hua-ping; YIN Xiu-ying; LIN Hai-yan
ObjectiveTo analyze the therapeutic effect of Acarbose combined with Tongxinluo Capsules in coronary heart disease (CHD)patients with impaired glucose tolerance.MethodsA total of 120 patients with CHD complicated with impaired glucose tolerance admitted into our hospital were selected as research objects.They were divided into group A(n=33),group B(n=27),group C(n=31)and group D(n=29)according to the random number table method.The patients of the group A were treated with conventional treatment of secondary prevention of CHD,the patients of the group B were treated with Acarbose on the basis of the conventional treatment,the patients of the group C were treated with Tongxinluo Capsules on the basis of the conventional treatment and the patients of the group D were treated with Acarbose and Tongxinluo Capsules on the basis of the conventional treatment.The occurrence of cardiovascular events,results of coronary angiography and ratios of albumin-creatinine(UACR)within continuous half a year of follow up visits among the four groups were compared and analyzed.ResultsThe basic heart rate,body mass index,systolic pressure,diastolic blood pressure,blood lipid(total cholesterol,low density cholesterol and triglycerides),fasting blood-glucose and blood-glucose of 2 h after 75 g oral glucose,UACR and other general datas were compared of patients of the four groups,the differences were not statistically significant(P＞0.05).The results of coronary angiography were compared in four groups,the differences were not statistically significant(P＞0.05).After six months of follow-up,the UACR in group D was significantly lower than that of group B and C,and the differences were statistically significant(P＜0.05).The incidence of cardiovascular events in group A was higher than that in group B,C and D,and incidence of cardiovascular events in group D was lowest,the differences were statistically significant(P＜0.05).The incidence of cardiovascular events was compared in group B,C and D,the differences were not statistically significant(P＞0.05).ConclusionFor CHD patients with impaired glucose tolerance,combination of Acarbose and Tongxinluo Capsules can obtain a remarkable effect.The effect is better than single medication.It is beneficial to reduce the UACR level and reduce the incidence of adverse cardiovascular events,it is worth promoting the application.
2018 Vol. 25 (3): 91-93转97 [Abstract] ( 208 ) HTML (27 KB)  PDF  (0 KB)  ( 67 )
94 Analysis and interference on irrational medical orders in pharmacy intravenous admixture services
LIU Hua; GENG Zhou; WANG Xiao-lan; YANG Wen-bing; SU Cun-jin ;PAN Jie
ObjectiveTo gather and analyze the irrational use of intravenous drugs in hospitalized patients,in order to promote the rational medication.MethodsThe 1 102 593 medical orders of intravenous drugs in pharmacy intravenous admixture service center(PIVAS)of the second affiliated hospital of Soochow University from March 2016 to March 2017 were collected,and retrospectively analyzed.ResultsThere were 1579 irrational medication orders,accounting for 0.14%.The irrational medication orders mainly involve improper selection of drugs(1.58%),solvent type(11.21%),volume(33.19%),irrational dosage(16.91%),incorrect medication route(0.82%),interval(15.83%)and incompatible drug use (20.46%).ConclusionThe intervention of the prescription-checking pharmacists greatly ensured rational clinical medication,thus reducing adverse events of drug application.
2018 Vol. 25 (3): 94-97 [Abstract] ( 163 ) HTML (27 KB)  PDF  (0 KB)  ( 55 )
98 Effect comparison of different methods in the treatment of newly diagnosed type 2 diabetes mellitus
ZHAO Sa ;SHI Yi-shan
ObjectiveTo compare the efficacy and safety between Glargine Insulin plus Melformin and Insulin Aspart 30 Injections in newly diagnosed type 2 diabetes mellitus patients(T2DM).MethodsA total of 68 newly diagnosed type 2 diabetes mellitus patients who hospitalized in the endocrinology department of our hospital from October 2015 to October 2016 were selected as subjects and were randomized into Glargine Insulin plus Melformin group(Gla+Mel group)and Insulin Aspart 30 Injections group(Asp 30 group),34 cases in each group,and they were treated for four weeks.The blood glucose,the blood glucose up to standard time,the incidence of hypoglycemia and the patient satisfaction rate were compared between the two groups.ResultsAfter 4 weeks of treatment,the FBG,2 h PG and HbA1c of the two groups were significantly lower than those in the group before treatment,and the differences were statistically significant(P＜0.05).The FBG,2 h PG and HbA1c of patients in Gla+Mel group were compared with Asp 30 group,and the differences were not statistically significant(P＞0.05).The blood glucose up to standard time of patients in the two group were compared,and the difference was not statistically significant(P＞0.05).The incidence of hypoglycemia in Gla+Mel group was significantly lower than that in the Asp 30 group,and the difference was statistically significant(P＜0.05).The satisfaction rate of patients in the Gla+Mel group was significantly higher than that of Asp 30 group,and the difference was statistically significant(P＜0.05).ConclusionFor newly diagnosed type 2 diabetic mellitus patients,Glargine Insulin plus Melformin could control blood glucose well,the incidence of hypoglycemia is low,and the satisfaction of treatment is high.
2018 Vol. 25 (3): 98-100 [Abstract] ( 144 ) HTML (27 KB)  PDF  (0 KB)  ( 81 )
101 Effect comparison of Parecoxib Sodium and Dexmedetomidine alone and combined use on postoperative early cognitive function in elderly patients
LING Wei-xian;HE Li-chan
ObjectiveTo study and compare the effect of Parecoxib Sodium and Dexmedetomidine alone and combined use on postoperative early cognitive function in elderly patients.MethodsFrom July 2016 to June 2017,137 elderly patients who underwent total hip replacement,femoral head replacement and total knee joint replacement in our hospital were selected as subjects.According to the randomized control method,the patients were divided into Parecoxib Sodium group(hereinafter referred to as group P,n=42),Dexmedetomidine group(hereinafter referred to as group D,n=47),and combined group (n=48).In the operation,the treatment was performed with Parecoxib Sodium,Dexmedetomidine and a mixture of both.The concentrations of S-100β protein,neuron-specific enolase(NSE)and MoCA scores of 1 h(t0)before surgery,3 h(t1),24 h(t2)and 72 h(t3)after the surgery and the incidence rate of postoperative cognitive impairment of patients in the three groups were compared.ResultsThe serum S-100β protein content at t1of the patients in the combined group was significantly lower than those in group P and group D,the serum S-100β protein and NSE content in t2and t3were significantly lower than those in group P and group D,and the differences were statistically significant(P＜0.05).The MoCA scores of the patients in the combined group were significantly higher than those in group P and group D,and the differences were statistically significant(P＜0.05).The incidence rate of POCD in the group(14.5%)was significantly lower than that in group P(28.5%)and group D(29.7%),and the differences were statistically significant(P＜0.05).ConclusionThe combination of Parecoxib Sodium and Dexmedetomidine in the elderly patients for maintenance anesthesia can significantly reduce the incidence of postoperative cognitive impairment.The effect is better than single use,which is worthy of promotion and application.
2018 Vol. 25 (3): 101-104 [Abstract] ( 157 ) HTML (32 KB)  PDF  (0 KB)  ( 105 )
105 Clinical study of Edaravone combined with Clopidogrel in the treatment of acute cerebral infarction
LI Tian-bao; YAN Xin-zheng ;WANG Hai-yan
ObjectiveTo investigate the efficacy of Edaravone combined with Clopidogrel in the treatment of acute cerebral infarction.Methods120 patients with acute cerebral infarction treated in our hospital from June 2015 to June 2017 were selected as subjects.All patients were randomly divided into two groups according to the random number table method,60 cases in each group.The control group was treated with Clopidogrel,and the experimental group was treated with Edaravone combined with Clopidogrel.The clinical efficacy,the activity of daily living scale(ADL)score and neurological function(NIHSS)score of the two groups were compared.ResultsThe total effective treatment rate in the experimental group (90.00%)was higher than that in the control group (66.67%),and the difference was statistically significant(P＜0.05).After treatment,both ADL and NIHSS scores in two groups were lower than those before treatment,and the scores of ADL and NIHSS in the experimental group were lower than those in the control group,and the differences were statistically significant(P＜0.05).ConclusionThe application of Clopidogrel combined with Edaravone in treatment of acute cerebral infarction patients can improve the patient′s symptoms,have a significant effect on neural function and improve the quality of life and change.It is worth promoting the application in clinical treatment.
2018 Vol. 25 (3): 105-107 [Abstract] ( 157 ) HTML (25 KB)  PDF  (0 KB)  ( 100 )
108 Analysis of the effect of Chloropidogrel Sulfate and Aspirin on stable angina pectoris
WAN De-li
ObjectiveTo explore the value of the treatment of Chloropidogrel Sulfate combined Aspirin in patients with stable angina pectoris.Methods200 patients with stable angina treated in our hospital from March 10,2015 to August 30,2016 were selected as subjects and were devided into two groups according to the patient treatment plan,100 cases in each group.Patients in the control group received Aspirin treatment on the basis of routine treatment such as Atorvastatin and Betalogram,while patients in the experimental group were treated with Aspirin and Chloropidogrel Sulfate.The clinical efficacy,the occurrence of adverse reactions,the number of angina pectoris onset,the duration of the attack and fibrinogen level were compared.ResultsThe total effective treatment rate in the experimental group (94.00%)was significantly higher than that in the control group(84.00%),and the difference was statistically significant(P＜0.05).After treatment,the number of angina pectoris onset of patients in the two groups were less than before treatment,the duration of the attack were shorter than before treatment,at the same time,the number of angina pectoris onset of patients in the experimental was less than that in the control group,the duration of the attack was shorter than that in the control group,the fibrinogen levels was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference of the occurrence of adverse reactions between the two groups(P＞0.05).ConclusionIt is significant that patients with stable angina pectoris should be treated with Chloropidogrel Sulfate combined with Aspirin to improve the curative effect and the cardiac function of patients.It is of great significance and is worthy of clinical application.
2018 Vol. 25 (3): 108-110 [Abstract] ( 158 ) HTML (26 KB)  PDF  (0 KB)  ( 96 )
111 Effect of Tacrolimus in the treatment of membranous nephropathy and its effect on patients with T lymphocyte subsets
MIAO Sheng-ju ;CHEN Li-sa▲HAN Fang
ObjectiveTo investigate the effect of Tacrolimus in the treatment of membranous nephropathy and its effect on patients with T lymphocyte subsets.MethodsFrom October 2015 to July 2017,82 patients with membranous nephropathy treated in our hospital were selected as subjects of the study and were divided into two groups according to the random number table method,41 cases in each group.Prednisone was used in all patients.In addition to the control group,the patients were treated with Leflunomide,and the patients in the observation group were treated with Tacrolimus,6 months was one course of treatment.The levels of the 24 h urinary protein,serum creatinine,CD3+,CD4+/CD8+before and after treatment and the total effective of clinical treatment between the two groups were compared.ResultsAfter treatment,the 24 h urinary protein and serum creatinine levels in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The CD3+and CD4+/CD8+in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total effective treatment rate in the observation group(80.49%)was higher than that in the control group(58.54%),and the difference was statistically significant(P＜0.05).ConclusionTacrolimus combined with Prednisone is effective in treating membranous nephropathy,which can improve renal function,regulate immune function,be safe and reliable,and worth promoting.
2018 Vol. 25 (3): 111-113 [Abstract] ( 192 ) HTML (30 KB)  PDF  (0 KB)  ( 77 )
114 Application effect of We-Chat platform for health guidance in patients with type 2 diabetes
HUANG Xiao-di
ObjectiveTo investigate the application effect of We-Chat platform for health guidance in patients with type 2 diabetes.Methods200 cases of patients with Type 2 diabetes treated in our hospital from June 2015 to June 2016 were selected as research objects and were divided into telephone group (control group)and We-chat group(observation group)rantomly,each group has 100 cases of patients.The patients in the control group were given regular health guidance and telephone follow-up,and the We-Chat platform was established of patients in the observation group to guide their families.The drug compliance,the level of FBG,2 h PG and GHb,the adverse reaction and the incidence of drug bias after one year follow-up were compared between the two groups.ResultsThe total compliance rate in the observation group(98.00%)was higher than that in the control group(90.00%),and the difference was statistically significant(P＜0.05).After intervention,two groups of patients of FBG,2 h PG and GHb were obviously lower than those before intervention,and the observation group of patients with FBG,2 h PG and GHb were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The incidence of adverse drug reactions in the two groups was not statistically significant(P＞0.05).The incidence of drug bias in the observation group(5.00%)was lower than that in the control group (17.00%),and the difference was statistically significant(P＜0.05).ConclusionWe-Chat platform can improve drug compliance in patients with type 2 diabetes by health guidance and can better control blood glucose in patients with type 2 diabetes.
2018 Vol. 25 (3): 114-116 [Abstract] ( 161 ) HTML (26 KB)  PDF  (0 KB)  ( 66 )
117 Protective effect of Buzhong Yiqi Decoction on liver mitochondrial function in mice infected by candida albicans
LIN Tong;ZHANG Yu-qi;LI Xiao-yue

ObjectiveTo discuss the protective effect of Buzhong Yiqi Decoction on liver mitochondrial function in mice infected by candida and its mechanism.Methods40 male Kunming mice were given intraperitoneal injection of candida albicans suspension after pretreatment by CTX and then made into models infected by candida albicans and were randomly divided into the control group(n=20)and experimental group(n=20).Mice in the control group were given Antifungal therapy,while mice in the experimental group were given antifungal drug combined with Buzhong Yiqi Decoction.The survival rate,mitochondriopoiesis index,nitrosative stress index and hepatic pathology were observed.ResultsSurvival rate was significantly higher in the experimental group than that in the control group(70%vs.30%,P=0.011).The level of PGC-1α mRNA was significantly higher in the experimental group than that in the control group(P＜0.05).The nitrosative stress index was significantly lower in the experimental group than in the control group,the difference was statistically significant(P＜0.05).Conclusionof hepatic sinusoid observed by light microscope was lighter in the experimental group than that in the control group.Conclusion Buzhong Yiqi Decoction may protect the liver mitochondrial function and facilitate mitochondriopoiesis in mice infected by candida albicans via inhibition of nitrosative stress.
2018 Vol. 25 (3): 117-119 [Abstract] ( 131 ) HTML (28 KB)  PDF  (0 KB)  ( 73 )
120 The study of bone metabolism markers in schizophrenia
WU Yong ;WAN Jing; PING Jun-jiao; XUE Kun-xi;REN Yan-zhen; HUANG Cai-ying;DU Bao-guo
ObjectiveTo explore the levels of bone metabolism markers in first-episode schizophrenia without treatment and schizophrenia who were treated with atypical antipsychotics.MethodsFirst-episode,treated with atypical antipsychotics schizophrenia and healthy controls were chosen to participate this study from April 2016 to October.These patients were outpatient or in-patient and each group included 40.The blood concentrations of bone metabolism markers of 3 groups,including OC,PTH,PTNP,VitD-T and β -CTX were compared.ResultsLevels of OC,PTNP and β -CTX in first-episode and treatment groups were higher than the control group and the differences were significant(P＜0.01).Levels of VitD-T and PTH were lower than the control group and the differences were significant(P＜0.01).β-CTX blood concentration in the first-episode group was higher than the treatment group,and the difference was significant(P＜0.01)ConclusionThe levels of bone metabolism markers in first-episode schizophrenia are abnormal and clinical workers should take measures to prevent the risk of fracture.
2018 Vol. 25 (3): 120-122 [Abstract] ( 153 ) HTML (26 KB)  PDF  (0 KB)  ( 72 )
123 Comparative analysis of the clinical value of immunoassay and routine examination in prenatal examination of pregnant women
WU Jie-ru
ObjectiveTo explore the clinical value of immunoassay in prenatal examination of pregnant women.Methods60 pregnant women who received delivery in our hospital from March 2013 to February 2016 were selected as the research subjects.Pregnant women who underwent routine testing were used as the control group,and the pregnant women were used immunoassay on the basis of routine test as the observation group,30 cases in each group.The detection rate of abnormal conditions and the satisfaction degree of the two groups were compared.ResultsThe positive detection rate of hepatitis B virus,the positive detection rate of microorganism,the detection rate of syphilis,the positive detection rate of HIV and the total detection rate in the observation group were higher than those in the control group,with significant difference (P＜0.05).The high risk pregnancy rate in the observation group was 10.00%,which was significantly lower than that of the control group(36.67%),with significant difference(P＜0.05).The intervention satisfaction degree by immunoassay of the pregnant women in the observation group was 96.67%,which was significantly higher than that of the control group(70.00%),with significant difference(P＜0.05).ConclusionImmunological examination has significant clinical value in prenatal examination of pregnant women.Through immunoassay,potential factors in high-risk pregnancy during pregnancy can be found in time,and taking targeted measures can reduce the risk of pregnant women during pregnancy,and ensure the safety of pregnant women.
2018 Vol. 25 (3): 123-125 [Abstract] ( 164 ) HTML (25 KB)  PDF  (0 KB)  ( 85 )
126 Value analysis of serum human epididymis protein 4 in the diagnosis of ovarian cancer
LIU Lian-bin;ZHOU Mao-hua;YU Ying;XUE Ling;LI Rong;WANG Qi;ZHOU Xiao-juan;LIN Wei
ObjectiveTo explore the application value of HE4 in the diagnosis of ovarian cancer by detecting human epididymal protein 4 (HE4)and CA125 in ovarian cancer,benign ovarian tumor and healthy population.MethodsFrom May 2015 to December 2016,the cases that conform to the criteria for admission in Tumor Hospital of Ganzhou City were selected.The serum level of HE4 of 57 cases of patients with ovarian cancer(the ovarian cancer group),49 cases of ovarian benign tumor patients(the benign ovarian tumor group)and 100 healthy people(the control group)were detected by electrochemiluminescence(ECL)detection method,and the results were compared with the detection results of CA125.ResultsThe level of serum HE4 in the ovarian cancer group was(329.7±215.3)pmol/L,which was significantly higher than that in the ovarian benign tumor group([37.6±25.3]pmol/L)and in the control group([23.5±9.1]pmol/L),with significant difference (P＜0.01).The sensitivity and specificity of HE4 in the diagnosis of ovarian cancer were higher.The sensitivity and specificity of HE4 and CA125 in the detection of ovarian cancer with different methods could reach 91.23%and 95.91%respectively,which were more advantageous than that in the single tumor markers.ConclusionThe serum level of HE4 has high diagnostic value for ovarian cancer,and it might be a markers in the diagnosis of ovarian cancer.
2018 Vol. 25 (3): 126-128 [Abstract] ( 169 ) HTML (29 KB)  PDF  (0 KB)  ( 66 )
129 Study on TORCH screening during pre-pregnancy and early pregnancy among women of childbearing age in Dongguan Region
LIANG Fu-xiao; YU Xun; YE Wan-ling; LIU Mei-xia
ObjectiveTo analyze the results of TORCH screening during pre-pregnancy and early pregnancy in women of childbearing age in Dongguan Region.MethodsFrom March 2016 to February 2017,10 041 women of childbearing age who were screened for TORCH during pre-pregnancy and early pregnancy in our hospital were selected as study subjects.8782 cases became pregnant.According to the pregnancy outcomes,there were 814 cases in the adverse pregnancy group,and 7968 cases in the normal pregnancy group.Toxoplasma gondii,Rubella virus,Cytomegalovirus,Herpes simplex virus IgM,IgG antibody of the study subjects were tested by chemiluminescence immune detection system.The correlation between pregnancy outcomes and TORCH screening results was observed.ResultsThe pathogen with the highest positive rate of IgM was Herpes simplex virus,and the pathogen with the highest positive rate of IgG was Cytomegalovirus.The positive rates of IgM of various pathogens in the adverse pregnancy group was higher than that in the normal pregnancy group,and the differences were statistically significant(P＜0.05).ConclusionTORCH screening during pre-pregnancy and early pregnancy in women of childbearing age has an important clinical significance in improving the quality of the population and is worthy of popularization and application.
2018 Vol. 25 (3): 129-131 [Abstract] ( 190 ) HTML (25 KB)  PDF  (0 KB)  ( 63 )
132 Application value of C reactive protein combined with blood routine detection in infection disease in pediatric respiratory tract
LI Nan-de; LAO Li-fen ;GUAN Rong-ju
ObjectiveTo investigate the application value of C reactive protein (CRP)combined with blood routine detection in infectious diseases in pediatric respiratory tract.Methods124 cases of respiratory tract infection in children from March 2016 to April 2017 treated in our hospital were selected as the research object,according to the different test methods,all patients were divided into the control group and the observation group,62 cases in each group.The control group was carried out the blood routine detection,the observation group was carried out the blood routine combined with CRP detection,the detection results and the treatment of the two groups were compared.ResultsIn the children of the observation group,12 cases(19.35%)were CRP≤8 mg/L,20 cases(32.26%)with CRP＞8 mg/L,46 cases(74.19%)with WBC and CRP increase simultaneously.In the control group,there were 14 cases(22.58%)of WBC increase,and 10 cases (16.13%)with WBC reduction.The total effective rate of treatment in the observation group was 98.38%,which was higher than that of the control group of 79.03%,with significant difference (P＜0.05).ConclusionThe combined application of blood routine and CRP in the detection of respiratory tract infection in pediatrics can improve the accuracy of bacterial infection.In addition,the assessment and treatment of the infection degree of understanding of the situation also has application value,can ensure the clinical rational use of drugs,so it is worthy of further promotion in clinical inspection work in pediatrics.
2018 Vol. 25 (3): 132-134 [Abstract] ( 174 ) HTML (26 KB)  PDF  (0 KB)  ( 62 )
135 Application value analysis of ELISA and Chemiluminescence in detection of serum HIV-1,HIV-2 and HCV antibodies
HUANG Yan-qing;LIN Yu-ye
ObjectiveTo analyse the significance of ELISA and CLIA value on serum HIV-1 antibody,HIV-2 antibody,HCV antibody detection.Methods1188 blood samples collected in our hospital from March 2016 to June 2017 were selected.HIV-1 antibody,HIV-2 antibody and HCV antibody were detected by ELISA and CLIA respectively.Western blot test results as HIV-1 antibody,HIV-2 antibody test gold standard,PCR test results as HCV antibody test gold standard,the diagnostic effects of both methods were compared.ResultsIn the detection of HIV-1 antibody,HIV-2 antibody,the Kappa of CLIA method with Western blot was 0.923,which was higher than that of the ELISA method(0.768).The Youden index of CLIA was 0.999,which was higher than that of the ELISA(0.832).In the detection of HCV antibody,the Kappa of CLIA method with Western blot was 0.898,which was higher than that of the ELISA method(0.831).The Youden index of CLIA was 0.905,which was higher than that of the ELISA (0.831).ConclusionIn the detection of HIV-1,HIV-2,HCV,the sensitivity,specificity of CLIA is higher,and more consistent with the gold standard,which is worthy of clinical promotion.
2018 Vol. 25 (3): 135-137转141 [Abstract] ( 172 ) HTML (28 KB)  PDF  (0 KB)  ( 67 )
138 Significance of uric acid,plasma cystatin C and high sensitive C reactive protein in the formation of carotid atherosclerosis in acute cerebral infarction
ZHANG Tian
ObjectiveTo investigate the significance of uric acid,plasma cystatin C and high sensitivity C reactive protein in the formation of carotid atherosclerosis in acute cerebral infarction.Methods100 cases of acute cerebral infarction treated in the Neurology Department of the Third Hospital of Nanchang City from January 2014 to December 2016 were randomly selected as the observation group,the clinical data of the patients were analyzed retrospectively.In addition,100 healthy volunteers without cerebral infarction and carotid atherosclerosis lesions were selected as the control group at the health check-up center of our hospital at the same time.The difference of uric acid,plasma cystatin C and hypersensitive C reactive protein between the two group were compared.On this basis,according to the degree of carotid atherosclerotic plaques,all patients were divided into the soft plaque group,the hard plaque group and the mixed plaque group,the level of uric acid,plasma cystatin C and hypersensitive C reactive detection values were compared.According to the prognosisis,all patients were divided into the good prognosis group and the poor prognosis group,and the same three indexes were compared.ResultsThe level of serum uric acid in the observation group was significantly lower than that in the normal group,the levels of plasma cystatin C and hypersensitive C reactive protein in the observation group were significantly higher than those in the control group,with significant difference (P＜0.05).The serum uric acid level of the soft plaque group was significantly lower than that of the hard plaque group and the mixed plaque group,the levels of plasma cystatin C and high sensitive C reactive protein in the soft plaque group were significantly higher than those in the hard plaque group and the mixed plaque group,with significant difference(P＜0.05).The level of serum uric acid in the mixed plaque group was significantly lower than that in the hard plaque group,and the level of plasma cystatin C and hypersensitivity C reactive protein in the mixed plaque group were significantly higher than those in the hard plaque group,with significant difference(P＜0.05).There was significant difference in the levels of serum uric acid,plasma cystatin C and hypersensitive C reactive protein between the poor prognosis group and the good prognosis group(P＜0.05).ConclusionUricacid,plasma cystatin,hypersensitive C reactive protein are closely related to the formation of carotid atherosclerosis in patients with acute cerebral infarction.The three parties participate in the occurrence and development of carotid atherosclerosis in acute cerebral infarction,which must be paid more clinical attention to.
2018 Vol. 25 (3): 138-141 [Abstract] ( 145 ) HTML (30 KB)  PDF  (0 KB)  ( 67 )
142 Evaluating the therapeutic effect of pulmonary tuberculosis by serum albumin，hemoglobin and prealbumin combined detection
ZHENG Song;CHENG Jie;LI Mei;WANG Dian-chao;PENG Ling
ObjectiveTo investigate serum albumin(ALB),hemoglobin(HGB)and prealbumin(PA)in the evaluation of therapeutic effect of pulmonary tuberculosis.Methods147 patients with pulmonary tuberculosis in our hospital from October 2015 to March 2017 were selected as research object.Based on the control of pulmonary tuberculosis patients,serum albumin,hemoglobin and prealbumin in patients with pulmonary tuberculosis before and after treatment were measured to evaluate the therapeutic effect.ResultsThe level of ALB,PA and HGB of the patients with pulmonary tuberculosis increased after treatment,and the difference of ALB and PA after treatment was statistically significant compared with that before treatment(P＜0.001).There was no significant difference in hemoglobin before and after treatment(P=0.245).The change in albumin was not affected by gender(P=0.601)and age(P=0.707),but was positively correlated with hospitalization time (P＜0.001).Prealbumin was not affected by patient sex,age and hospitalization time (P＞0.05).ConclusionThe changes of serum PA and ALB levels can be used as an objective criterion for monitoring the therapeutic effect of pulmonary tuberculosis drugs,and prealbumin is not affected by the gender,age and hospitalization time in patients with tuberculosis.
2018 Vol. 25 (3): 142-144 [Abstract] ( 179 ) HTML (25 KB)  PDF  (0 KB)  ( 72 )
145 Correlation between HbA1c level and pregnancy outcome in pregnant women with gestational diabetes mellitus
HUANG Zi-kai
ObjectiveTo investigate the correlation between glycosylated hemoglobin(HbA1c)levels and pregnancy outcomes in pregnant women with gestational diabetes mellitus(GDM).MethodsAltogether 30 cases of pregnant women with GDM who underwent antenatal examinations and delivery in department of obstetrics and gynecology in our hospital from April 2015 to April 2016 were selected as the study group,while,30 healthy pregnant women who underwent examinations during the same period and had normal blood glucose levels were randomly selected as the control group.The differences of HbA1c levels and adverse pregnancy outcomes between the two groups were recorded and analyzed,and the correlation between the two groups was analyzed.ResultsThe level of HbA1c in the study group was higher than that of the control group,with statistically significant difference(P＜0.05).The incidence of premature rupture of membranes,amniotic fluid abnormalities and preterm birth of the study group was significantly higher than that of the control group,with statistically significant difference(P＜0.05).The premature rupture of membranes,abnormal amniotic fluid,premature delivery,fetal distress and postpartum hemorrhage of the study group were positively correlated with HbA1c,with statistically significant difference(P＜0.05).There was no significant difference in gestational age at delivery and Apgar score between the two groups(P＞0.05),while the level of blood glucose in the study group was higher than that in the control group,with statistically significant difference(P＜0.05).ConclusionThe premature rupture of membranes,abnormal amniotic fluid,premature delivery,fetal distress and postpartum hemorrhage of patients with gestational diabetes mellitus are positively correlated with HbA1c levels.The incidence of maternal complications rate increases with the increase of HbA1c level.Therefore,close monitoring of patients′HbA1c level can reduce the incidence of adverse symptoms,which is worthy of application in primary hospitals.
2018 Vol. 25 (3): 145-147 [Abstract] ( 202 ) HTML (25 KB)  PDF  (0 KB)  ( 72 )
148 Influence of hyperlipidemia on the detection of electrolyte by indirect ion selective electrode
JIA Li-sha
ObjectiveTo understand the influence of severe hyperlipidemia on the detection of serum electrolyte K+,Na+,Cl-by indirect ion selective electrode method.MethodsSerum samples of normal blood lipid,mild to moderate blood lipid and severe blood lipid were selected,20 case in each group.K+,Na+,Cl-were detected by Hitachi 7600 automatic biochemical analyzer and the Roche cobas b 123 blood gas analyzer,comparing the results.The results were compared and analyzed.ResultsFor specimens of normal and mild and moderate blood hyperlipidemia,there was no significant difference in the detection results between the Hitachi 7600 automatic biochemical analyzer and the Roche cobas b 123 blood gas analyzer(P＞0.05).The detection results of severe hyperlipidemia of the Hitachi 7600 automatic biochemical analyzer was lower than that of the Roche cobas b 123 blood gas analyzer,with significant difference (P＜0.05).ConclusionThe results of direct ion selective electrode method for detecting K+,Na+,Cl-are more true and reliable for severe lipid blood samples.
2018 Vol. 25 (3): 148-150 [Abstract] ( 142 ) HTML (27 KB)  PDF  (0 KB)  ( 80 )
151 Correlation analysis of serum lactic acid content and the degree of nerve injury and myocardial damage in children with hand-foot-mouth disease
CHEN Mu-rong
ObjectiveTo investigate the correlation between serum lactic acid content and the degree of nerve injury and myocardial damage in children with hand-foot-mouth disease.MethodsFrom June 2015 to June 2017,37 children with hand-foot-mouth disease complicated with encephalitis were enrolled as the encephalitis group.The other 58 children only with hand-foot-mouth disease at the same time were selected as the simple hand-foot-mouth disease group.The content of lactic acid in serum was determined by enzyme colorimetric method.The indexes of nerve injury and content of inflammatory factors were determined by enzyme linked immunosorbent assay (ELISA).The content of myocardial enzymes in serum was determined by radioimmunoassay.Pearson test was used to evaluate the correlation between serum lactic acid content and severity of nerve injury in children with hand-foot-mouth disease complicated with encephalitis.Results The content of lactic acid in children in the encephalitis group was higher than that in the simple hand-foot-mouth disease group(P＜0.05).The contents of neuron specific enolase(NSE),S-100B protein(S-100B),and myelin basic protein (MBP)in the encephalitis group were significantly higher than those in the simple hand-footmouth disease group (P＜0.05).Meanwhile,the levels of serum LDH,CK-MB,α-HBDH,and AST in children in the encephalitis group were higher than those in children in the simple hand-foot-mouth disease group (P＜0.05).The serum lactate content in children with hand foot and mouth disease is positively correlated with the nerve damage index NSE,S-100B and MBP(r=0.245,0.195,0.318,P＜0.05).The serum lactate content in children with hand foot and mouth disease is positively correlated with myocardial enzyme spectrum LDH,CK-MB,α-HBDH,AST (r=0.275,0.415,0.512,0.198,P＜0.05).ConclusionThe serum lactic acid level in children with hand-foot-mouth disease rises,and the indexes of nerve injury and myocardial damage also increase,which display a positive correlation,therefore,the serum lactic acid content can be used as a predictive index of nerve injury and myocardial damage in hand-foot-mouth disease.
2018 Vol. 25 (3): 151-153 [Abstract] ( 203 ) HTML (26 KB)  PDF  (0 KB)  ( 98 )
154 Changes of serum thyroid function and immune content and its clinical application in patients with hyperthyroidism during pregnancy
LIANG Miao-zhi;CHEN Dong-lian; WANG Fei-ma;SONG Xing-xian; YANG Ying
ObjectiveTo explore the changes of serum thyroid function and immune content in patients with hyperthyroidism during pregnancy and its clinical application.Methods122 pregnant patients with hyperthyroidism treated from May 2015 to December 2016 in our hospital were selected as the observation group,120 pregnant women without hyperthyroidism were selected as the control group at the same time.The immune function and thyroid function at the different gestational periods between the two groups were compared.ResultsThe index of TSH at the early,mid,late trimester of pregnancy in the observation group was lower than that in the control group,the level of T3,FT3,T4,FT4at the early,mid,late trimester of pregnancy in the observation group was higher than that in the control group,with significant difference (P＜0.05).The positive rate of TRAb,Anti-TG and TPOAb at the early,mid trimester of pregnancy in the observation group was higher than that in the control group,with significant difference (P＜0.05).There was no significant difference in the positive rate of TRAb between the two groups (P＞0.05).The positive rate of Anti-TG and TPOAb at the late trimester of pregnancy in the observation group was higher than that in the control group,with significant difference (P＜0.05).ConclusionThe thyroid function and immunoglobulin contents at the different gestational periods are significantly different.It is necessary to attach great importance to this kind of patient,to diagnose and treat early,to check the thyroid function regularly and improve the outcome of maternal and infant.
2018 Vol. 25 (3): 154-156 [Abstract] ( 181 ) HTML (26 KB)  PDF  (0 KB)  ( 71 )
157 Application of PBL+microlectures teaching methods in experimental teaching of central nervous system
YANG Bo;YIN Jian;YANG Ben;HU Zhao-yong;LIAO Jun;CHEN An;LI Liang
ObjectiveTo observe the effect of problem-based learning (PBL)method in the experimental teaching of central nervous anatomy.Methods100 students of five year undergraduate students of clinical specialty of Hunan University of Chinese Medicine in 2014 were selected and they were randomly divided into the control group and the observational group,with 50 people in each group.The control group received the traditional teaching method,and the observational group was given PBL+microlectures method.After the experimental teaching of CNS,traditional test questions,cases and practical test questions and questionnaire survey were applied to evaluate effects of these two teaching methods.ResultsThe score of traditional questions,cases and practical questions in the observational group were obviously higher than that in the control group (P＜0.05).The percentage of liking degree to the classroom teaching model,teaching satisfaction degree for classroom,classroom learning effects,classroom learning efficiency,classroom improving the learning interest and enthusiasm,classroom improving the ability of independent thinking,the classroom helping to develop and improve the ability to analyze and solve problems in the observation group was obviously higher than that those of the control group(P＜0.05 or P＜0.01).ConclusionPBL+microlecture methods can improve experimental teaching quality of central nervous anatomy and is beneficial to improve students′interest in learning and efficiency,and to improve their ability to analyze and solve problems and so on.It is worthy of promotion.
2018 Vol. 25 (3): 157-159 [Abstract] ( 154 ) HTML (28 KB)  PDF  (0 KB)  ( 85 )
160 Establishment of clinical skills training and evaluation system in Jiangxi Province
GUAN Xi-hong;LUO Li-sheng;CHEN Yu;XIONG Chang-hui;DONG Yong-hai
To explore and establish the clinical skills training and evaluation system in Jiangxi Province,strengthen the clinical practice skills training of medical personnel in our province,improve the ability and level of medical service,and ensure the medical quality and safety,Health and Family Planning Commission of Jiangxi Province has taken a series of measures including organizing expert verification,clinical practice skills training and competition,and survey on satisfaction,and formulated Implementation Scheme of Clinical Practice Skills Training and Competition in Jiangxi Province in 2015 and 2016,2016-2020 Plan of Clinical Practice Skills Training and Competition in Jiangxi Province,and supportive documents of training assessment system about training.By successful holding of the clinical practice skills training and competition in 2015 and 2016,it is proved that establishment of clinical skills training and evaluation system in 2015 in Jiangxi Province is operable and effective to standardize the clinical practice skills and improve the level of clinical skills.
2018 Vol. 25 (3): 160-162转166 [Abstract] ( 147 ) HTML (31 KB)  PDF  (0 KB)  ( 73 )
163 Probe on basic nursing teaching mode based on combination of clinical practice and teaching
XU Gui-na;TAN Gui-huang;CAO Xue-qun
ObjectiveTo explore the active and effective basic nursing teaching mode to improve the quality of teaching and enhance the students′core competence.MethodsThe students of grade 2016 in class 1 and 2 of junior college in our school were exacted as object.Class 1 was randomly chosed as be the control group,and class 2 was the experimental group.The control group was given the traditional teaching theory classroom teaching,while the experimental group was given the combination mode of clinical simulation teaching and clinical clerkship.In the end of the semester,the same papers were used for theoretical assessment,and self-made questionnaire was used to carried out the teaching effect.ResultsThe theoretical examination results of students in the experimental group were higher than those of the control group(P＜0.01),and the performance evaluation were higher than that of the control group(P＜0.01).The learning interest,understanding ability,thinking ability,practical ability,communication ability,cooperation ability,comprehensive ability and the recognition of teaching reform in the experimental group were all higher than those in the control group(P＜0.01).ConclusionTeaching mode of combination of clinical practice and teaching used can improve the quality of teaching and improve the core competence of students,which is conducive to the development of schools and disciplines.
2018 Vol. 25 (3): 163-166 [Abstract] ( 172 ) HTML (29 KB)  PDF  (0 KB)  ( 77 )
167 Feedback and countermeasures of functional science design experiment teaching
HUANG Yan-feng
To carry out the functional design experiment can improve students′ability of practice,research and innovation consciousness,the comprehensive ability of applying knowledge,is the effective means to mobilize students′learning,but also promote the teachers improve their own quality,promote the basic medical experimental teaching reform.Combined with the practice and exploration of 10 years,The author makes a summary and discussion on the present situation of the functional science design experiment and the feedback of the students.At the same time,the author puts forward the corresponding countermeasures to the problems arising in the process of implementation.
2018 Vol. 25 (3): 167-169转173 [Abstract] ( 165 ) HTML (26 KB)  PDF  (0 KB)  ( 70 )
170 Application research on the teaching method based on clinical pathway in the standardized training of medical residents in respiratory department
XIAO Kun; XIE Li-xin
ObjectiveTo explore the application effect of teaching method based on the clinical pathway in the standardized training of hospitalized physicians in respiratory department.MethodsFrom August 2014 to June 2017,235 hospitalized doctors who participated in the training of respiratory medicine in PLA General Hospital were randomly divided into experimental group(n=118)and control group(n=117)according to the entry time.In the experimental group,the mode of clinical pathway teaching was used,and in the control group,traditional teaching mode was applied.The score of professional theoretical knowledge,clinical skills,case analysis ability,and patients′satisfaction degree were compared between the two groups after department.ResultsIn the experimental group,the score of case analysis ability and clinical skills were both higher than those in the control group([91.56±4.32]points vs.[82.26±5.81]points;[87.83±3.25]points vs.[81.77±4.57]points),which were both displayed statistical differences(P＜0.05).The scores of professional theoretical knowledge was(85.54±5.78)points and(82.41±6.22)points in the experimental group and control group respectively,which was not displayed a great difference (P＞0.05).The total satisfaction degree of the resident doctors in the experimental group(88.4%)was significantly higher than that of the control group(75.5%),and the difference was statistically significant(P＜0.05).ConclusionThe teaching method based on clinical pathway can obviously improve the abilities of clinical record analysis and skill operation as well as patients′satisfaction degree,and is beneficial to cultivate the clinical thinking of resident doctors,and is worthy of further promotion in clinical teaching.
2018 Vol. 25 (3): 170-173 [Abstract] ( 169 ) HTML (29 KB)  PDF  (0 KB)  ( 74 )
174 The value observation of psychological intervention in the nursing of chronic pelvic inflammatory disease
YU Ping; HU Bi-hua
ObjectiveTo study and analyze the clinical effect of psychological intervention in the nursing of chronic pelvic inflammatory disease.MethodsFrom May 2015 to June 2016,84 patients with chronic pelvic inflammatory disease received by the department of obstetrics and gynecology of our hospital were selected,and the patients were randomly divided into control group and observation group,with 42 patients in each group.Control group of patients were given ward regularly disinfected and observing vital signs such as routine nursing care,observation group was given the new hospital,hospital nursing intervention measures on the basis of the control groip,the nursing effect of the two groups was compared.ResultsTreatment efficiency of patients in observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).After nursing,SDS and SAS scores of patient of two groups were significantly lower than that before treatment,the difference was statistically significant(P＜0.05);SDS and SAS scores of patients in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05),the nursing satisfaction of the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).ConclusionFor chronic pelvic inflammation disease patients,implementation of psychological nursing intervention can obtain a remarkable clinical efficacy and increase the therapeutic effectiveness rate,which is worthy of promotion in clinic.
2018 Vol. 25 (3): 174-176 [Abstract] ( 164 ) HTML (27 KB)  PDF  (0 KB)  ( 63 )
177 Therapeutic effect analysis of cluster nursing combined with routine nursing in children with Kawasaki disease
GUO Feng-ping
ObjectiveTo analyze the application effect of cluster nursing combined with routine nursing in children with Kawasaki disease.Methods84 patients with kawasaki disease admitted to our hospital from October 2014 to July 2017 were selected,and were divided into control group and study group according to the single and double number method,with 42 cases in each group.In the control group,routine nursing was carried out,and the study group was combined with cluster nursing on the basis of this nursing,and the improvement of clinical indicators and the patient′s family satisfaction of the two groups were compared.ResultsThe CRP content and white blood cell content of the study group were less than that of the control group,and the difference was statistically significant(P＜0.05).Team average defervescence time,length of hospital stay of the study group were shorter than that of the control group,the difference was statistically significant(P＜0.05),the parents satisfaction of the study group was significantly lower than that of the control group,the difference was statistically significant(P＜0.05).ConclusionThe combination of intensive care and routine nursing can significantly improve the clinical symptoms of children with Kawasaki disease,improve the family care satisfaction of children,shorten the recovery time,is worthy of clinical selection and comprehensive promotion.
2018 Vol. 25 (3): 177-179 [Abstract] ( 169 ) HTML (25 KB)  PDF  (0 KB)  ( 66 )
180 Clinical significance analysis of early enteral nutrition and nursing in patients with severe neurological diseases
ZHU Xiao-wen
ObjectiveTo study and explore the clinical significance of early enteral nutrition and nursing in critically ill patients of Neurology department.MethodsA total of 60 critically ill patients admitted to our hospital from January 2014 to March 2017 were prospectively studied.They were divided into control group and observation group by random number table,with 30 cases in each group.The control group adopted routine enteral nutrition support,and the observation group adopted early enteral nutrition support,and the nursing intervention was applied to the two groups during the period of nutritional support.Two groups of Neurology severe patients were compared in terms of nutritional indicators,immune function indexes,and the incidence of complications.ResultsAfter treatment,the nutrition indicators of the observation group were higher than those of the control group,the difference was statistically significant(P＜0.05);before treatment,compared two groups of immune function indexes,the difference was not statistically significant(P＞0.05),but after treatment,the immune function indexes of the observation group were better than those of the control group,and the difference was statistically significant(P＜0.05).The incidence of complications in the observation group was significantly lower than that of the control group,and the difference was statistically significant(P＜0.05).ConclusionEarly enteral nutrition support and nursing intervention can effectively improve the nutritional status and immune function of patients with severe neurological diseases,and also can reduce complications,it is propitious to improve prognosis.
2018 Vol. 25 (3): 180-182 [Abstract] ( 164 ) HTML (25 KB)  PDF  (0 KB)  ( 65 )
183 Influence of special nursing intervention on sleep quality in elderly patients with pulmonary heart disease
PENG Chun-ling
ObjectiveTo explore the influence of special nursing intervention on the sleep quality of elderly patients with pulmonary heart disease.Methods96 cases of elderly patients with pulmonary heart disease who were cleary diagnosed in our hospital from January 2014 to December 2015 were selected.They were divided into control group and observation group by random number table method,with 48 cases in each group.In the control group,routine nursing was carried out,and special nursing intervention was performed in the observation group.The nursing effects of the two groups was compared.ResultsThe sleep quality score of the observation group was significantly lower than that of the control group(P＜0.05).The optimal rate of treatment in the observation group was significantly higher than that in the control group(P＜0.05).ConclusionSpecial nursing intervention can be achieved in elderly patients with pulmonary heart disease,which can improve the quality of sleep and improve the therapeutic effect.
2018 Vol. 25 (3): 183-185 [Abstract] ( 198 ) HTML (25 KB)  PDF  (0 KB)  ( 74 )
186 Study on the effect of humanistic care on nursing satisfaction and quality of life in patients with rectal cancer
YANG Qing
ObjectiveTo study the effect of humanistic care on nursing satisfaction and quality of life in patients with rectal cancer.Methods90 cases of rectal cancer treated in our hospital from August 2015 to August 2016 were selected.They were divided into control group and experimental group by random number table method,45 cases in each group.The control group was given routine professional nursing of perioperative colorectal cancer,and the experimental group was given humanistic nursing and care on this basis.The SF-36 quality of life scale was used to evaluate and compare the differences of quality of life.At the same time,the self-made questionnaire of nursing satisfaction in our hospital was used to survey and the nursing satisfaction of the two groups was compared.ResultsQuality of life index of patients of two groups after treatment was improved significantly compared with before treatment(P＜0.05),and the quality of life index score in the experimental group was significantly higher than that in control group(P＜0.05);the nursing satisfaction of patients in the experimental group was significantly higher than that in the control group(P＜0.05).ConclusionThe humanistic nursing care has an obvious effect on improving quality of life and improving nursing satisfaction in the patients with rectal cancer,which is suitable for promotion.
2018 Vol. 25 (3): 186-188 [Abstract] ( 181 ) HTML (25 KB)  PDF  (0 KB)  ( 68 )
189 Analysis on the effect of operation room comprehensive nursing on postoperative incision infection
ZHENG Qing-liang
ObjectiveTo evaluate the efficacy of operation room comprehensive nursing in reducing postoperative incision infection.MethodsFrom May 2015 to June 2016,562 patients undergoing surgical treatment in our hospital were selected as the research subjects.The patients were divided into control group(283 patients)and observation group(279 patients)according to the admission time.The control group was given routine operation room nursing,and the observation group was given the comprehensive nursing strategies such as training,preoperative surgical program discussions,operation room environmental management on the basis of the experience of nursing at home and abroad,as well as the experience of nursing in our department.The incision infection rate,mortality rate,nursing satisfaction and length of stay in the two groups of patients were compared.ResultsPostoperative incision infection rate and in-hospital mortality patients of observation group were significantly lower than those in the control group,the difference was statistically significant(P＜0.05),intraoperative blood loss of patients of two groups had no statistically significant difference(P＞0.05);The patients in the observation group were significantly shorter than the control group in the period of hospitalization and the 30%cut in the incision,and the difference was statistically significant(P＜0.05).The nursing satisfaction score of the observation group was better than the control group,and the difference was statistically significant(P＜0.05).ConclusionFor the patients in the operation room,the application of comprehensive nursing strategies can reduce the postoperative incision infection rate,shorten the length of hospital stay,improve the comfort of hospitalization and quality of care,and can reduce postoperative mortality and improve nursing efficacy.
2018 Vol. 25 (3): 189-191转194 [Abstract] ( 148 ) HTML (30 KB)  PDF  (0 KB)  ( 68 )
192 Effect of comfort nursing on reducing pain and improving quality of life in postoperative patients with lumbar spinal compression fracture
LIUChun-lian; KEJin-ping ;ZHUMin-ling
ObjectiveTo study the effect of comfort nursing on the pain and quality of life of patients with lumbar vertebral compression fractures.Methods90 cases of compression fracture of the aged lumbar spine were selected in our hospital From March 2016 to March 2017.The random number method was used to divide into control group and observation group,with 45 cases in each group.All patients were treated with surgical treatment.The patients in the observation group were given comfortable nursing care,and the control group was treated with traditional basic nursing.The VAS score and Barthel index score of the two groups were compared.ResultsThere was no significant difference in the preoperative VAS score between the two groups(P＞0.05),and the VAS score in the observation group was significantly lower than that of the control group(P＜0.05).There was no significant difference in the Barthel index score between the two groups before operation (P＞0.05).The Barthel index score of the observation group in six months was significantly higher than that of the control group (P＜0.05).ConclusionIn the elderly patients with lumbar vertebral compression fractures,the use of comfort nursing can significantly reduce the pain and improve the quality of life,it is worthy of clinical promotion.
2018 Vol. 25 (3): 192-194 [Abstract] ( 178 ) HTML (24 KB)  PDF  (0 KB)  ( 76 )
195 The role of systematic nursing intervention in reducing adverse reactions of intravenous infusion and improving nursing satisfaction
FENG Yu-li;CHEN Qi-ni;ZHAO Jin-li
ObjectiveTo explore the role of systematic nursing intervention in reducing adverse reactions of intravenous infusion and improving nursing satisfaction.Methods247 patients in our hospital emergency department with intravenous infusion from February 2015 to March 2017 were selected,and were divided into experimental group (n=134)and control group(n=113)according to the random control grouping method.The two groups were given systematic nursing intervention and traditional nursing intervention mode respectively.The incidence of adverse reactions and nursing satisfaction scores of the two groups were analyzed and compared.ResultsThe incidence of adverse reactions in the intervention group was lower than that in the control group(P＜0.05),and the score of nursing satisfaction in the intervention group was higher than that in the control group(P＜0.05).ConclusionSystematic nursing intervention can effectively reduce the adverse reactions of emergency intravenous infusion,and improve the satisfaction of nursing.
2018 Vol. 25 (3): 195-197 [Abstract] ( 172 ) HTML (26 KB)  PDF  (0 KB)  ( 71 )
Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech