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Quick Search     Adv Search 2020 Vol. 27, No. 19 Published: 2020-07-08   4 Clinical effect and safety of Albumin-bound Paclitaxel combined with Nedaplatin in the treatment of advanced recurrent nasopharyngeal carcinoma TONG Yan-li；MEI Qing-hua；ZENG Si-yu；YANG Shui-yuan Objective To observe the clinical effect and safety of Albumin-bound Paclitaxel combined with Nedaplatin in the treatment of advanced recurrent nasopharyngeal carcinoma. Methods The clinical data of 78 patients who received Paclitaxel combined with Platinum for chemotherapy after relapse of advanced nasopharyngeal carcinoma in our hospital from August 2016 to June 2019 were retrospectively analyzed. Patients with Albumin-bound Paclitaxel combined with Nedaplatin for chemotherapy were used as the observation group, and patients with common Paclitaxel Injection combined with Nedaplatin for chemotherapy were used as the control group, with 39 cases in each group. After 4 cycles of chemotherapy, the short-term efficacy and incidence of adverse reactions in the two groups of patients were evaluated. Results After 4 cycles of chemotherapy, the total remission rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference in the incidence of hematological toxicity between the two groups (P＞0.05). In terms of non-hematological toxicity, the incidence rates of skin rash, facial flushing and peripheral neurotoxicity in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the incidence rate of nausea and vomiting between the two groups (P＞0.05). Conclusion Albumin-bound Paclitaxel combined with Nedaplatin in the chemotherapy of advanced recurrent nasopharyngeal carcinoma has good clinical effect, with fewer allergic reactions such as skin rash and facial flushing, and good tolerance. 2020 Vol. 27 (19): 4-7 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 8 Study on the regulatory network and potential mechanism of Bezoar in the treatment of cerebral infarction LIANG Yu-hua；HE Hua-hua；DENG Tai-ping Objective To predicit the potential target of Bezoar in the treatment of cerebral infarction via network pharmacology and to explore its regulatory network and mechanism of action. Methods The main active components of Bezoar were were obtained through traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP) database and literature mining, and the target of the active ingredients of Bezoar was predicted and screened using the human gene database GeneCards. String database and Cytoscape 3.7.1 software were used to draw protein interaction (PPI) network, and gene ontology (GO) analysis of potential genes was performed with the application of DAVID6.8 database. Results A total of 5 active ingredients of Bezoar were obtained by screening, involving 3 targets.GO analysis results showed that the biological process of Bezoar in the treatment of cerebral infarction mainly involved steroid hormone receptor activity, nuclear receptor activity, transcription factor activity, steroid binding, vitamin D receptor binding, nuclear receptor binding, chromatin DNA binding, and ATPase binding, etc. Conclusion The treatment of cerebral infarction by Bezoar is a complex process with multiple components and multiple targets, mainly by regulating the three targets of NR3C2, PGR and RXRA, involving nuclear receptor activity, transcription factor activity,steroid binding, vitamin D receptor binding, chromatin DNA binding, ATPase binding and other biological processes to play a role in intervening cerebral infarction. 2020 Vol. 27 (19): 8-11 [Abstract] ( 43 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 12 Determination of recovery rate of Aconitine skin microdialysis in vitro and study on its influencing factors GUO Li-rong；XU Song；LI Na Objective To investigate experimental factors affecting recovery rate of Aconitine skin microdialysis in vitro. Methods The effect of persuate flow rate, Aconitine concentration and ambient temperature on the recovery rate of microdialysis in vitro was investigated by gain method and loss method. Results The recovery rate of microdialysis in vitro decreased with the increasing of perfusate flow rate. The Aconitine concentration has little effect on the recovery rate of microdialysis in vitro. The higher the ambient temperature, the higher the recovery rate of microdialysis in vitro.Conclusion The recovery rate of Aconitine skin microdialysis in vitro is affected by the perfusate flow rate and ambient temperature, and not affected aconitine concentration. 2020 Vol. 27 (19): 12-16 [Abstract] ( 41 ) HTML (40 KB)  PDF  (0 KB)  ( 6 ) 17 Research progress of NK cells in immune abnormal spontaneous abortion LI Yan-bin；WANG Ling；WU Yun-ting；CHEN Jin-hong NK cells (natural killer cells) are important immune cells in the body and have characteristic changes in normal pregnancy and patients with spontaneous abortion(especially those with recurrent abortion).With the development of reproductive immunology,research on NK cells at home and abroad has become a hot spot and has made breakthrough progress. NK cells appear in the central, peripheral immune organs and multiple non-immune organs with a variety of cell phenotypes, and their physiological or pathological changes have an important impact on the pregnancy process.Therefore, this article summarizes the results of domestic and foreign research on the changes in the number,phenotype, and receptors of peripheral blood NK cells and decidual NK cells in patients with spontaneous abortion, and integrates the treatment progress of modern medicine and traditional Chinese medicine for NK cell-related spontaneous abortion. 2020 Vol. 27 (19): 17-21 [Abstract] ( 46 ) HTML (50 KB)  PDF  (0 KB)  ( 6 ) 22 Research progress of circular RNA in the area of reproduction and pregnancy ZHAO Yi-yan；JU Jie；KONG Xiang Circular RNA is an endogenous no-coding RNA (ncRNA) that naturally exists in living organisms and has a covalently closed loop structure. It plays an important role in the regulation of gene expression. It acts as microRNA(miRNA) in the circular RNA-miRNA-mRNA axis, regulating alternative splicing and parental gene expression. With the development of technology in recent years, people have gradually discovered that circular RNA with unique biological characteristics has broad development and application space in clinical disease prediction, early intervention and diagnosis and treatment, and has become a research focus in recent years. However, circular RNA is relatively rare in non-tumor obstetrics and gynecology diseases. Therefore, circular RNA is briefly introduced and its research progress in non-tumor related diseases in human reproduction and pregnancy is briefly summary in this article. 2020 Vol. 27 (19): 22-26 [Abstract] ( 48 ) HTML (47 KB)  PDF  (0 KB)  ( 7 ) 27 Research progress in diagnosis of Helicobacter pylori infection CEHN Chen；ZHOU Xue-jun；HE Ying Endoscopic imaging is constantly being improved. In addition to narrow band imaging, blue laser imaging,linked color imaging and convolutional neural networks combined with artificial intelligence systems can be clinically applied to observe Helicobacter pylori (HP) infection. In chronic active gastritis, immunohistochemistry is recommended clinically if Hp is not detected by standard staining or there are rare and special bacterial infections. The molecular method based on real-time polymerase chain reaction (PCR) has shown a high accuracy both for detecting Hp infection and drug-resistant Hp. The most reliable non-invasive test remains the urea breath test. The sensitivity of stool antigen test is comparable to the urea breath test, and may be a good alternative to the latter. This article divides the related methods for the diagnosis of Hp infection into two categories: invasive and non-invasive, and reviews the relevant methods for the diagnosis of Hp infection 2020 Vol. 27 (19): 27-30 [Abstract] ( 44 ) HTML (40 KB)  PDF  (0 KB)  ( 6 ) 31 Research advances on chemical constituents and pharmacological effect of Nelumbinis stamen SONG Jing；CHEN Ya-nan；RAO Gao-xiong Based on the literature review, this paper summarizes the current situation of the studies on the record,chemical composition, content determination and pharmacological action of Nelumbinis stamen, so as to provide a basis for the follow-up study of Nelumbinis stamen. At present, the research on the chemical components of Nelumbinis stamen is relatively insufficient, and the pharmacological action is mainly the activity study of the total extract, the active components and the mechanism of action are not obvious, and there is no clear index component in the Chinese Pharmacopoeia for the determination of its content. Therefore, in the later stage, the chemical components of Nelumbinis stamen can be further studied, which can provide scientific basis for the better development and utilization of Nelumbinis stamen 2020 Vol. 27 (19): 31-34 [Abstract] ( 43 ) HTML (41 KB)  PDF  (0 KB)  ( 9 ) 35 Clinical effect of CO2 dot lattice laser combined with hyaluronic acid in the treatment of hypertrophic scars LONG Li-yun Objective To investigate the effect of CO2 dot lattice laser combined with hyaluronic acid introduction on hypertrophic scars. Methods From January 2018 to July 2019, 30 patients with hypertrophic scars who were treated in the outpatient clinic and then admitted into the hospital for surgery were selected as the research subjects. They were divided into observation group (n=15) and control group (n=15) by double blind method. In the observation group,hyaluronic acid combined with CO2 lattice laser was used, while in the control group, CO2 lattice laser alone was used.The clinical effect and adverse reactions of the two groups were compared. The changes of the scores of color, softness,thickness or blood vessel distribution in the two groups were explored. Results The total incidence of adverse reactions and the total effective rate of treatment were compared between the two groups, and the differences were not statistically significant (P＞0.05). Before treatment, there were no statistically significant differences in the scores of color, softness, thickness or blood vessel distribution between the two groups (P＞0.05). After treatment, the scores of color, softness, thickness and blood vessel distribution of the observation group were lower than those of the control group, with statistical significance (P＜0.05). Conclusion The use of CO2 dot lattice laser combined with hyaluronic acid in the treatment of hypertrophic scars can enhance the effect of wound and facilitate good prognosis. 2020 Vol. 27 (19): 35-37-41 [Abstract] ( 53 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 38 Effect observation and nursing of continuous irrigation of abdominal double cannula combined with external application of Mirabilite in the treatment of severe acute pancreatitis LI Xue-qin；HUANG Wen-lei；LI Xiao-xia；ZHANG Nuo-bei Objective To explore the clinical effect and nursing method of continuous irrigation of abdominal double cannula combined with external application of mirabilite in the treatment of severe acute pancreatitis (SAP). Methods A total of 142 patients with SAP who were admitted to our hospital from October 2018 to October 2019 were selected.They were divided into two groups by random number table method, 71 cases in each group. The control group was given regular treatment, and the experimental group was given continuous irrigation with abdominal double cannula combined with external application of Mirabilite. The course of treatment was 1 week, accompanied by nursing intervention during the period. The vital signs, inflammation index levels, and symptom improvement time were compared between the two groups until four weeks later, and pancreatic exudative absorption was evaluated. Results The differences in vital signs and levels of inflammation indices before treatment were not statistically significant between the two groups (P＞0.05); the average arterial pressure in the experimental group after 1 week of treatment was (87.95±7.76) mmHg higher than that in the control group of (83.64±7.82) mmHg, respiratory frequency, heart rate, white blood cell count (WBC), creactive protein (CRP) ([19.11±2.29] times/min, [93.88±8.69] times/min, [12.09±2.06] ×109/L,[37.62±7.78] mg/L) were lower than those in the control group ([21.43±2.18] times/min, [100.47±8.83] times/min,[13.57±2.24] ×109/L, [45.35±8.62] mg/L), and the differences were statistically significant (P＜0.05); the time of improvement in fever, abdominal pain and distention in the experimental group([4.36±1.65],[4.13±1.29],[6.38±1.77] d) were shorter than those in the control group ([5.89±2.03] d, [5.72±1.68] d, [8.43±2.52] d), and the differences were statistically significant (P＜0.05); the pancreatic exudative absorption rate in the experimental group (88.73%) was higher than that in the control group (76.06%), and the difference was statistically significant (P＜0.05). Conclusion The continuous irrigation of abdominal double cannula combined with external application of mirabilite has a significant effect in the treatment of SAP, which effectively improves the patients′ vital signs and symptoms, reduces inflammation and index level, and promotes pancreatic exudative absorption. Combined nursing intervention can further reduce the risk of treatment. 2020 Vol. 27 (19): 38-41 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 42 Prospective randomized controlled study of preoperative intestinal decontamination in the prevention of acute pancreatitis after ERCP SHU Hong-chun；LIAN Huo-jun；ZHUGE Qun；ZHOU Wei-ping；ZHENG Mei-hong；DENG Hui-qiu Objective To investigate the curative effect of preoperative intestinal decontamination on preventing acute pancreatitis and hyperamylasemia in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).Methods Altogether 110 patients who underwent ERCP in our hospital from January 2019 to January 2020 were selected as the study subjects. According to the random number table method, the subjects were divided into the experimental group and the control group, 55 cases in each group. ERCP was performed in both groups. The experimental group was given Compound Polyethylene Glycol Electrolyte Powder 2000 ml orally at 7 pm before operation, and the control group was given clear water 2000 ml orally.The levels of WBC,ALT and TBil were measured before and 24 hours after operation.The incidence of acute pancreatitis and hyperamylasemia was recorded between the two groups.The defecation time, abdominal pain score, hospitalization time and medical expenses were compared between the two groups.The prognosis during hospitalization and other complications were observed between the two groups. Results The levels of WBC, ALT and TBil at 24 hours after operation in the two groups were lower than those before operation, and the differences were statistically significant (P＜0.05). The levels of WBC, ALT and TBil 24 hours after operation in the experimental group were lower than those in the control group, with significant differences (P＜0.05). The incidence of acute pancreatitis and hyperamylasemia after ERCP in the experimental group was lower than that in the control group,with significant difference (P＜0.05). Postoperative defecation time and hospitalization time of the experimental group were shorter than those of the control group, abdominal pain score was lower than that of the control group, and medical expense was lower than that of the control group, with significant differences (P＜0.05). The cure discharge rate of the experimental group was higher than that of the control group, and the mortality of the experimental group was lower than that of the control group, and the differences were statistically significant (P＜0.05). The incidence of infection and bleeding after operation in the experimental group was lower than that in the control group, with significant difference(P＜0.05). Conclusion Preoperative intestinal decontamination can reduce the incidence of acute pancreatitis after ERCP, alleviate postoperative abdominal pain and other discomforts, improve the prognosis of patients and reduce medical costs, which is worthy of clinical application. 2020 Vol. 27 (19): 42-45 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 46 Effect of Xuebijing Injection on intestinal function and inflammatory factors in critically ill patients CHEN Zhi-xin；YAN Bin-yi；ZHANG Fa-yang；ZHOU Rong Objective To investigate the effect of Xuebijing Injection on intestinal function and inflammatory factors in critically ill patients. Methods From January 2018 to January 2019, 100 critically ill patients treated in our hospital were selected as subjects for the study. They were divided into control group (n=50) and research group (n=50) by the random number table method. Patients in the control group were treated with routine therapy, while patients in the study group were treated with Xuebijing Injection. Both groups were treated for 7 d, plasma levels of diamine oxidase(DAO), endotoxin (LPS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were compared before and after treatment between the two groups. The oxygenation index (OI), acute physiological and chronic health score (APACHE Ⅱ)were compared between the two groups. Results After treatment for 7 days, the DAO and LPS levels in both groups were lower than those before treatment, with statistically significant differences (P＜0.05). After treatment for 7 days, the DAO and LPS levels in the research group were lower than those in the control group, the differences were statistically significant (P＜0.05). After treatment for 7 days, the TNF-α, IL-6 levels in both groups were lower than those before treatment, with statistically significant differences (P＜0.05). After treatment for 7 days, the levels of TNF-α and IL-6 in the research group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment for 7 days, the OI values of the two groups were higher than those before treatment, and the APACHE Ⅱscores of the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05).After treatment for 7 days, the OI value of the research group was higher than that of the control group, and the score of APACHE Ⅱwas lower than that of the control group, the differences were statistically significant (P＜0.05). The feeding time of the research group was shorter than that of the control group, the difference was statistically significant(P＜0.05). Conclusion Xuebijing Injection can effectively reduce the level of DAO, LPS, improve the intestinal function of critically ill patients, and effectively reduce the level of inflammatory factors and the severity of the disease, which is worthy of extensive clinical use. 2020 Vol. 27 (19): 46-49 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 50 Effect of three types of glucocorticoid administration on lung function and inflammatory status of acute exacerbation of chronic obscructive pulmonary disease XIAO Wen-xiang；LI Jing；LIU Hong-mei Objective To investigate the effects of three kinds of Glucocorticoids on pulmonary function and inflammatory status of acute exacerbation of chronic obscructive pulmonary disease (AECOPD). Methods A total of 60 patients with AECOPD admitted to our hospital from September 2018 to October 2019 were selected as the research subjects,according to the random number table method, they were divided into group A (oral Prednisone), group B (intravenous Methylprednisolone), and group C (nebulized inhaled Budesonide), each had 20 cases. All three groups of patients received conventional treatments such as asthma, phlegm and cough relief, oxygen inhalation, nutritional support, and correction of electrolyte balance. Pulmonary function [forced expiratory volume in 1 second (FEV1), forced vital capacity(FVC), FEV1/FVC], serum inflammatory cytokines [tumor necrosis factor-α (TNF-α), C-reactive protein level (CRP) ]levels, the occurrence of adverse reactions were compared. Results There were no statistically significant differences in the levels of FEV1, FVC, and FEV1/FVC before treatment (P＞0.05). After 5 days of treatment, the levels of FEV1, FVC,and FEV1/FVC in the three groups were higher than those before treatment, and the difference were statistically significant (P＜0.05). The FEV1, FVC, FEV1/FVC levels in group B were higher than those in group C, the differences were statistically significant (P＜0.05). Ther was statistically significant difference in the above indicators of three groups (P＜0.05). The levels of serum TNF-α and CRP in the three groups before and after treatment were not statistically significant (P＞0.05); after 5 days of treatment, the levels of serum TNF-α and CRP in the three groups were lower than those before treatment (P ＜0.05). After 5 days of treatment, the total incidence of adverse reactions in groups A and B(40.00%, 35.00%) were higher than that in group C (5.00%), the differences were statistically significant (P＜0.05); adverse reactions in three groups, the difference in total incidence was statistically significant (P＜0.05). Conclusion Both intravenous drip therapy with Methylprednisolone and atomized inhalation therapy with Budesonide can effectively improve the lung function of AECOPD patients, reduce patients′ serum inflammatory factor levels, however, but the safety of Budesonide atomization inhalation therapy is higher. 2020 Vol. 27 (19): 50-53 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 54 Influence of enteral nutrition support via different catheterization modes on the complications and nutritional status of chronic obstructive pulmonary disease patients LIU Yan-ming；YE Qiu-rong；SU Ba-li；HE Zhi-ying；ZHONG Qiu-jie Objective To analyze the influence of enteral nutrition support via different catheterization modes on the complications and nutritional status of COPD (chronic obstructive pulmonary disease) patients. Methods A total of 60 patients with COPD who received enteral nutrition support in our hospital from January 2018 to December 2019 were selected for research. According to random number table, patients were assigned to control group (via nasogastric tube,n=30) and observation group (via nasal jejunal feeding tube, n=30). Upon 1 d and 14 d of admission, arm muscle circumference, serum albumin, hemoglobin, and prealbumin levels and complication rate were counted. Results Upon 1 d of admission, arm muscle circumference, serum albumin, hemoglobin and prealbumin levels between groups were not significantly different (P＞0.05); upon 14 d of admission, arm muscle circumference in the observation group was longer than that of control group; serum albumin, hemoglobin and prealbumin levels in the observation group were higher than those of control group, with statistically significant differences (P＜0.05); the incidence rate of complications like abdominal distension, diarrhea, emesis, regurgitation and gastric content retention in the observation group was lower than that of control group, with statistically significant difference (P＜0.05). Conclusion Introducing nasal jejunal catheterization for COPD patients with enteral nutrition support has fewer complications than nasogastric catheterization, which can improve the nutritional status of patients. It is an effective and safe, simple operation method of catheterization 2020 Vol. 27 (19): 54-56-60 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 57 Clinical effect of Reduning Injection in the treatment of sepsis-induced acute respiratory distress syndrome patients LI Wan-quan；WU Shan；QIU Chun-hui Objective To investigate the effect of Reduning Injection on the immune function of sepsis-induced acute respiratory distress syndrome patients, and the effect of Reduning Injection on the survival rate of sepsis-induced acute respiratory distress syndrome patients. Methods A total of 88 patients with sepsis-induced acute respiratory distress syndrome patients to our hospital from March 2018 to March 2019 were selected as the research objects, and they were divided into treatment group and reference group according to random number table method, 44 cases in each group.The patients in the reference group were treated with conventional Western medicine, and the patients in the treatment group were given Reduning Injection combined with conventional Western medicine treatment. During the treatment period, the immune function of the two groups of patients was observed, and the treatment efficacy and survival rate were statistically analyzed and evaluated. Results The CD3+, CD4+, CD4+/CD8+ of the patients in the treatment group were higher than those of the reference group, and the CD8+of the patients in the treatment group was lower than that of the reference group,the differences were statistically significant (P＜0.05).The total effective rate in the treatment group was 90.91%, higher than that in the reference group of 68.18%, the difference was statistically significant (P＜0.05); the survival rate of patients in the treatment group after 6 months of follow-up was 67.50% (27/40), the survival rate of the reference group 56.67% (17/30), the difference between the two groups was not statistically significant (P＞0.05). Conclusion Reduning Injection has obvious clinical effect in treating patients with sepsis-induced acute respiratory distress syndrome, and it has an impact on the immune function of patients, which is worthy of clinical promotion and application. 2020 Vol. 27 (19): 57-60 [Abstract] ( 50 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 61 Influence of stellate ganglion block on the patients with aneurysmal subarachnoid hemorrhage ZHANG Xu-biao；NIE Ying Objective To investigate the influence of stellate ganglion block (SGB) on the patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods A total of 78 patients with aSAH who were given invasive treatment under general anesthesia in our hospital from September 2017 to August 2019 were selected as the research subjects. They were divided into the observation group (39 cases) and the control group (39 cases) according to the random number table method. The control group was given conventional endotracheal intubation and resting combined with invasive therapy under maintenance anesthesia. The observation group was given Ropivacaine for SGB. The cerebral hemodynamic indicators (mean blood flow velocity [Vm] of middle cerebral artery [MCA], anterior cerebral artery [ACA], and posterior cerebral artery [PCA]), endothelin-1 (ET-1), S100B protein, neurospecific enolase (NSE) and the incidence of cerebral vasospasm (CVS) were compared between the two groups. Results There were no significant differences in VM of MCA, ACA PCA, and ET-1, S100B, NSE between the two groups before treatment (P＞0.05). After treatment, the Vm of MCA, ACA, PCA and ET-1, S100B, NSE in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The incidence rate of CVS in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion SGB can improve cerebral hemodynamics, reduce cerebral nerve damage, and reduce the incidence rate of CVS in the patients with aSAH. 2020 Vol. 27 (19): 61-63 [Abstract] ( 47 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 64 Clinical effect of Risperidone in the treatment of mental disorders induced by craniocerebral injury RAO Ying-hua；QIN Ming-jun；ZHANG Xun Objective To explore the influence of Risperidone on psychiatric symptoms, nerve function and social function in patients with mental disorders induced by craniocerebral injury. Methods A total of 40 patients with mental disorders induced by craniocerebral injury from October 2017 to October 2019 in our hospital were selected as the research objects. According to the random number table method, all participants were divided into the observation group(20 cases)and the control group(20 cases).The observation group was treated with routine therapy combined with Risperidone, while the control group was treated with routine therapy. The scores of National Institutes of Health Stroke scale(NIHSS),positive and negative syndrome scale(PANSS),activity of daily living(ADL)and treatment emergent symptom scale(TESS) were compared between the two groups before treatment and after 8 weeks of treatment. Results After 8 weeks of treatment, the total scores of NIHSS and PANSS in the observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05). After 8 weeks of treatment, the total scores of ADL and TESS in the observation group were higher than those of the control group, and the differences were statistically significant(P＜0.05). Conclusion The combination of Risperidone can promote the recovery of neurological function, improve the mental symptoms and improve the social function of patients with mental disorders induced by craniocerebral injury. 2020 Vol. 27 (19): 64-66-70 [Abstract] ( 35 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 67 Clinical effect of Levodopa combined with Pramipexole in the treatment of Parkinson′s disease with dementia YUE Li-lei Objective To investigate the clinical effect of Levodopa combined with Pramipexole in the treatment of Parkinson′s disease with dementia. Methods From January 2017 to December 2018, 100 patients with Parkinson′s disease with dementia were selected as the study subjects, which were divided into control group (50 cases) and study group (50 cases) according to the method of random drawing lots. The control group was treated with Levodopa, and the study group was treated with Levodopa combined with Pramipexole. The clinical efficacy of the two groups was compared, and the Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) scores before and after treatment of the two groups were compared, and the occurrence of adverse reactions in the two groups was compared. Results The total effective rate of clinical treatment in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05). The scores of HAMD and HAMA of the study group were lower than those of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The treatment of Levodopa combined with Pramipexole in patients with Parkinson′s disease with dementia can effectively improve their psychological status,and the incidence of adverse reactions is low, the therapeutic effect is remarkable. It has important value. 2020 Vol. 27 (19): 67-70 [Abstract] ( 46 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 71 Clinical effect of acupuncture combined with Yinao Zengzhi Decoction in the treatment of vascular dementia after cerebral infarction HUANG Ren-feng；CHEN Rong-hao；LI Xiao-min；GUAN Wen-feng；GUO Fu Objective To investigate the clinical effect of acupuncture combined with Yinao Zengzhi Decoction in the treatment of vascular dementia after cerebral infarction. Methods A total of 70 patients with vascular dementia after cerebral infarction admitted to our hospital from January 2018 to January 2019 were enrolled in the study. According to the random number table method, they were divided into the observation group and in the conventional group, 35 patients in each group. Patients in the conventional group were treated with conventional therapy, and the observation group was treated with acupuncture combined with Yinao Zengzhi Decoction. Hemodynamic parameters, mental improvement status scores, and daily living ability scores were compared between the two groups. Results The 120 s whole blood viscosity, hematocrit and plasma viscosity of the observation group were lower than those of the conventional group, the differences were statistically significant (P＜0.05). The scores of intelligence improvement and daily life ability of the observation group were higher than those of the conventional group, the differences were statistically significant (P＜0.05). Conclusion Acupuncture combined with Yinao Zengzhi Decoction can effectively improve the hemodynamic parameters of patients with vascular dementia after cerebral infarction, meanwhile, it can also effectively improve the intelligence improvement status score and the daily life ability score of patients, which is worth promoting. 2020 Vol. 27 (19): 71-73 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 74 Application effect of Tirofiban in acute cerebral infarction undergoing mechanical thrombectomy WEN Wei-wei；ZHANG Zhi-cheng Objective To explore the application effects of Tirofiban in acute cerebral infarction undergoing mechanical thrombectomy. Methods From February 2016 to February 2019, a total of 88 patients with acute cerebral infarction undergoing mechanical thrombectomy admitted in the Fifth People′s Hospital of Shenyang City were selected as research objects. According to the method of the table of random number, they were divided into the control group (45 cases) and the treatment group (45 cases). In the control group, Aspirin and Clopidogrel were used, while in the treatment group,Tirofiban bridged Aspirin and Clopidogrel was used. The score of National Institutes of Health Stroke scale (NIHSS),the score of Barthel index, and the total effective rate before and after treatment were compared between the two groups. Results The NIHSS score of the treatment group after treatment was lower than that of the control group, while the Barthel index score of the treatment group was higher than that of the control group, and the differences were statistically significant (P＜0.05). The total effective rate in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞0.05). Conclusion Antiplatelet therapy of Tirofiban in emergency mechanical thrombectomy maybe a safe and effective method, which is worthy of further clinical application. 2020 Vol. 27 (19): 74-76 [Abstract] ( 46 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 77 The relationship between neutrophil ratio before thrombolysis of acute ischemic stroke patients and their clinical outcome after thrombolysis LIU Chang；DONG Meng；LIU Ji-hong；ZOU Jia-lin；DONG Jun Objective To explore the relationship between the percentage of neutrophils before intravenous thrombolysis and clinical outcome after thrombolysis in patients with acute cerebral infarction. Methods A retrospective analysis of 118 patients with acute cerebral infarction who received intravenous thrombolysis in department of neurology in our hospital from August 2017 to August 2019. Early neurological deterioration was defined as at 24 h after thrombolysis the National Institutes of Health Stroke scale (NIHSS) score increased by ≥4 points before thrombolysis, and the poor prognosis was defined as a modified Rankin score of 3 months ＞2 points. Binary Logistic regression was used to analyze the independent risk factors of early neurological deterioration, poor prognosis and death within 3 months. Results There were 18 patients (15.3%) had early neurological deterioration, 55 patients (46.6%) had poor prognosis, and 23 patients (19.5%) died within 3 months. Logistic regression analysis showed that the percentage of neutrophils (OR=1.058, 95%CI=1.006-1.112) and NIHSS score before thrombolysis (OR=1.099, 95%CI=1.019-1.186) were independent risk factors for early neurological deterioration (P＜0.05); after correcting NIHSS score (OR=1.251, 95%CI= 1.145-1.366), the percentage of neutrophils (OR= 1.049, 95%CI=1.009-1.091) was still an independent risk factor for poor prognosis within 3 months (P＜0.05); atrial fibrillation (OR=3.600, 95%CI=1.079-12.017), percentage of neutrophils(OR=1.068, 95%CI=1.012-1.127) and NIHSS score before thrombolysis (OR=1.177,95%CI=1.068-1.297)were independent risk factors for death within 3 months after thrombolysis (P＜0.05). Conclusion The percentage of neutrophils before intravenous thrombolysis in patients with acute cerebral infarction has a certain predictive value for the clinical outcome after intravenous thrombolysis. 2020 Vol. 27 (19): 77-80 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 81 Clinical efficacy and safety of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease MA Chun-li；XU Tian-yin；WANG Yi-ning Objective To investigate the clinical effect and safety of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease. Methods From January 2017 to December 2018, 100 patients with Parkinson′s disease treated in our hospital were selected as subjects, and divided into control group (n=50) and study group (n=50) by random lottery method. Patients in the control group were treated with Levodopa, while patients in the study group were treated with Pramipexole combined with Levodopa. The clinical treatment effect of patients of the two groups was compared, the concise health status scale (SF-36) scores and the Hamilton depression scale (HAMD-17) scores of the two groups before and after treatment were compared, and the occurrence of adverse reactions of patients in the two groups was compared. Results The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, indexes of SF-36 scores in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). After treatment, the HAMD-17 score in the study group was lower than that in the control group, with statistically significant difference (P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of Pramipexole combined with Levodopa in the treatment of Parkinson′s disease can effectively improve the symptoms of the disease, improve the clinical efficacy, and has high safety. It has important clinical application value. 2020 Vol. 27 (19): 81-84 [Abstract] ( 47 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 85 Clinical effect of Valproic Acid combined with Lamotrigine in the treatment of epilepsy LANG Xiao-ling Objective To investigate the clinical effect of Valproic Acid combined with Lamotrigine in the treatment of epilepsy. Methods A total of 100 epilepsy patients admitted in our hospital from January 2017 to June 2019 were selected as subjects, and they were divided into two groups by random lottery, 50 cases in each group. The control group was treated with Valproic Acid, and the study group was treated with Valproic Acid combined with Lamotrigine. The clinical therapeutic effect, clinical symptoms and adverse reactions were compared between the two groups. Results The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, the number of seizures and epileptiform discharge in the study group were less than those in the control group, the duration was shorter than that in the control group, and the level of lead involvement number was lower than that in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Patients with epilepsy were treated with Valproic Acid combined with Lamotrigine, it can not only effectively improve the relevant clinical symptoms of patients, but also has high safety and low incidence of adverse reactions. It is worth popularizing in clinical application. 2020 Vol. 27 (19): 85-87 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 88 Clinical effect of Alprostadil on the treatment of early diabetic nephropathy ZHANG Qi-fen; YANG Ming-min;XIONG Yan;ZHOU Hai-xing;YU Ying Objective To investigate the clinical effect of Alprostadil Injection on microalbuminuria in early diabetic nephropathy (DN). Methods A total of 180 patients with early DN admitted to our hospital from June 2016 to June 2019 were selected as subjects, and divided into the treatment group (90 cases) and the control group (90 cases) according to the random number table. Patients in both groups were given conventional treatment. The control group was given oral Huangkui Capsules on the basis of conventional treatment. The treatment group was treated with intravenous Alprostadil Injection on the basis of the control group. The therapeutic course was 4 weeks in the two groups of patients. The total treatment efficiency of the two groups of patients after treatment was compared. Blood urea nitrogen(BUN), serum creatinine (SCr), glycosylated hemoglobin (HbA1c) and 24 h microalbumin (mAlb) were compared before and after treatment between the two groups. The incidence of adverse reactions after treatment between the two groups was compared. Results The total effective rate of treatment group was higher than that in the control group, the difference was statistically significant (P＜0.05). The mAlb, BUN, SCr and HbA1c after treatment in the treatment group were lower than those before treatment, while mAlb, BUN, SCr and HbA1c after treatment in treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in adverse reactions of two groups (P＞0.05). Conclusion Alprostadil combined with Huangkui Capsule for the treatment of patients with early DN can effectively improve clinical curative effect , decrease 24 h mAlb, delay renal function injury and be suitable for clinical application. 2020 Vol. 27 (19): 88-90-94 [Abstract] ( 49 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 91 Application of local anesthesia percutaneous nephroscope lithoipsy in patients with upper urinary tract calculi in grass-roots hospitals PAN Guo-quan Objective To explore the application of local anesthesia percutaneous nephroscope lithoipsy (PCNL) in patients with upper urinary tract calculi in grass-roots hospitals. Methods A total of 60 patients with upper urinary tract calculi admitted to our hospital from May 2018 to March 2020 were selected as the research objects. They were divided into control group (30 cases) and study group (30 cases) according to the random grouping method. The control group was treated with PCNL under combined spinal and epidural anesthesia, and the study group was treated with PCNL under local anesthesia. The surgical index, renal function index and pain grade of the two groups of patients were compared. Results The operation time, indwelling time and hospitalization time of the patients in the study group were shorter than those of the control group, and the stone clearance rate was higher than that of the control group, the differences were statistically significant (P＜0.05). Before surgery, there were no significant differences in blood urea nitrogen (BUN) and creatinine (Cr) between the two groups (P＞0.05). After surgery, BUN and Cr levels were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the degree of pain between the two groups (P＞0.05). Conclusion Carrying out local anesthesia PCNL in grass-roots hospitals to treat patients with upper urinary tract calculi can shorten the operation time and hospitalization time of patients, improve the stone clearance rate, and thus improve the renal function of patients. It is worthy of popularization and application in grass-roots hospitals. 2020 Vol. 27 (19): 91-94 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 95 Clinical effect of modified Devine surgery combined with dorsal foreskin skin flap turnover transvers treating severe concealed penis LUO Feng-zhen；LIU Li-xin Objective To explore the clinical effect of modified Devine surgery combined with dorsal foreskin skin flap turnover transvers treating severe concealed penis. Methods A total of 64 cases of severe concealed penis children admitted to our hospital from September 2018 to July 2019 were selected as the research objects. They were divided into control group and test group by random number table method, with 32 cases in each group. In the control group, only dorsal foreskin skin flap turnover transvers was used. In the test group, modified Devine surgery+dorsal foreskin skin flap turnover transvers was provided. The surgery time, penis length 3 months after surgery, flap survival, and penis appearance satisfaction were observed. Results According to statistics, the surgery time of the test group was longer than that of the control group, the penis length 3 months after the surgery was longer than that of the control group, and the total satisfaction was higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Modified Devine surgery combined with dorsal foreskin skin flap turnover transvers has a remarkable effect on treating severe concealed penis. It can not only extend the length of the penis and increase the survival rate of the flap,but also can obtain good penis appearance satisfaction from children. 2020 Vol. 27 (19): 95-97 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 98 Risk factors of urinary tract infection after transurethral resection of prostate SONG Jing；ZHANG Ling-ling；CHEN Lei；WANG Yang Objective To investigate the risk factors of urinary tract infection after transurethral resection of prostate.Methods A total of 200 cases of transurethral resection of prostate admitted to our hospital from January 2018 to February 2019 were selected as the study objects. According to the methods of postoperative urinary tract infection or not, they were divided into the observation group (100 cases) and the control group (100 cases). The observation group was accompanied by urinary tract infection, while the control group was free of urinary tract infection. The risk factors of urinary tract infection after transurethral prostatectomy was analyzed. Results There were statistically significant differences between the two groups of patients in age ≥70 years, operation time ＞1 h, indwelling catheter time ＞5 d, and preoperative preventive use of antibiotics without prevention (P＜0.05). Taken age ≥70 years, operation time ＞1 h, indwelling catheter time ＞5 d, and preoperative not preventive use of antibiotics as independent variables, postoperative urinary tract infection as the dependent variable, Logistic regression analysis was conducted. According to the results,age ≥70 years, operation time ＞1 h, indwelling catheter time ＞5 d, and preoperative preventive use of antibiotics for the urethra prostate electricity cut method in patients were risk factors for urinary tract infection (P＜0.05). Conclusion The risk factors for urinary tract infection after transurethral prostatectomy include age ≥70 years, operation time ＞1 h,indwelling catheter time ＞5 d, and preoperative not preventive use of antibiotics, and early reventive measures should be taken. 2020 Vol. 27 (19): 98-100 [Abstract] ( 47 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 101 Clinical effect of transurethral plasma resection of prostate in the treatment of benign prostatic hyperplasia HUANG Kao-ping；LI Zhong；WEN Shi-he；LIU Lan Objective To investigate the clinical effect of transhepatic plasma resection of prostate in the treatment of benign prostatic hyperplasia (BPH). Methods The clinical data of 138 patients with BPH treated in our hospital from January 2015 to June 2019 were analyzed retrospectively. According to the treatment scheme, the patients were divided into control group (69 cases) and observation group (69 cases). The patients in the control group were treated with transurethral resection of prostate and the patients in the observation group were treated with transurethral prostatectomy. The surgical indexes and residual urine volume of prostate symptom score were compared between the two groups.The incidence rates of penile erectile dysfunction and retrograde ejaculation in the two groups were analyzed. Results The operation time, postoperative bladder irrigation time and indwelling catheter time of the patients in the observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05). The amount of intraoperative blood loss and residual urine volume in the observation group were less than those of the control group,and the differences were statistically significant (P＜0.05). The prostate symptom score (IPSS score), the incidence of penile erectile dysfunction and retrograde ejaculation in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Transhepatic plasma resection of prostate is effective in the treatment of BPH, which can promote the rehabilitation of patients. 2020 Vol. 27 (19): 101-103 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 104 Influence of different operation timing of laparoscopic cholecystectomy on senile acute cholecystitis GU Lin-ming；ZHONG Zhu-luan；LUO Xiao-fang Objective To investigate the influence of different operation timing of laparoscopic cholecystectomy on senile acute cholecystitis. Methods The clinical data of 70 senile patients with acute cholecystitis who admitted to Shangrao Fifth People′s Hospital from March 2017 to March 2019 were retrospectively analyzed. The clinical data of 25 patients with symptom-to-operation time ＜48 h were classified as group A, the clinical data of 25 patients with symptom-to-operation time from 48 to 72 h were classified as group B, and the clinical data of 20 patients with symptom-to-operation time ＞72 h were classified as group C. The surgical indexes, conversion to laparotomy and the total incidence of complications were compared among the three groups. Results The total effective rate of patients in group A was higher than that in group C, and the difference was statistically significant (P＜0.05). There was no significant difference in the total effective rate between group A and group B (P＞0.05). There was no significant difference in the total effective rate between group B and group C (P＞0.05). The operative time, exhaust time and hospital stay of patients in group A were shorter than those in group B and group C, and the intraoperative blood loss was less than that in group B and group C, with statistical differences (P＜0.05). There was no statistical difference in the rate of conversion to laparotomy among the three groups (P＞0.05). There was no statistical difference in the total incidence of complications among the three groups (P＞0.05). Conclusion Laparoscopic cholecystectomy within 48 h of onset of symptoms for senile patients with acute cholecystitis has better efficacy, it can promote postoperative rehabilitation of patients. 2020 Vol. 27 (19): 104-107 [Abstract] ( 44 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 108 Application effect of multimodal analgesia based on the concept of rapid rehabilitation surgery in mixed hemorrhoid surgery XIANG Guang-yang；OU Chang-bai；ZHANG Xiao-wei；ZHOU Yun-tian Objective To explore the application and clinical effect of multimodal analgesia based on the concept of rapid rehabilitation surgery in mixed hemorrhoid surgery. Methods From January to June 2019, 60 patients with mixed hemorrhoids admitted to our hospital to undergo milligan-morgan hemorrhodectomy were selected as the research objects. They were divided into observation group and control group according to the order of admission, with 30 cases in each group. During the perioperative period, patients in the observation group were subjected to multimodal analgesia based on the concept of rapid rehabilitation surgery, while patients in the control group were subjected to traditional mode analgesia. Visual analogue scale (VAS) score, postoperative first defecation time, postoperative first ambulation time and postoperative hospital stay time were observed between the two groups. The occurrence of adverse reactions such as drowsiness, urinary retention, nausea and vomiting, itchy skin and respiratory depression within 48 h after operation were compared between the two groups. Results The VAS scores of the observation group at different postoperative time points (immediately after surgery, at the 4th, 12th, 24th and 48th hour after surgery) were lower than those of the control group, and the differences were statistically significant (P＜0.05). The first defecation time and the first time to get out of bed after the observation group were earlier than the control group, and the differences were statistically significant (P＜0.05). The incidence rates of drowsiness, nausea and vomiting, urinary retention, respiratory depression and skin pruritus between the two groups within 48 h after surgery were not statistically significant (P＞0.05). Conclusion The concept of rapid rehabilitation surgery in the perioperative application of patients with mixed hemorrhoids can significantly reduce the patients′ pain, has a good analgesic effect, facilitates the patients′ postoperative recovery, and does not increase the incidence of adverse reactions. 2020 Vol. 27 (19): 108-111 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 112 Clinical effect of laparoscopic cholecystectomy for acute cholecystitis CAI Wei-sheng；HUANG Huang-ye Objective To study the clinical effect of laparoscopic cholecystectomy in the treatment of acute cholecystitis (AC). Methods A total of 52 patients with AC treated in our hospital from June 2017 to June 2018 were selected as study subjects. The patients were randomly divided into two groups according to the random number table method, each had 26 cases. Patients in the control group underwent open cholecystectomy, patients in the experimental group underwent laparoscopic cholecystectomy. The immune function indexes, perioperative indexes, serum lipase (LPS), serum amylase (AMY) , and serum alkaline phosphatase (ALP) levels between the two groups were compared. Results Tn the postoperative, the levels of CD3+, CD4+, CD4+/CD8+experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The perioperative index of the experimental group in the postoperative group was less than that of the control group, the operation time and abdominal drainage time were shorter than those in the control group, and the amount of surgical bleeding was less than that in the control group, the differences were statistically significant (P＜0.05), The levels of LPS, AMY, and ALP in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusions Laparoscopic cholecystectomy is effective in treating AC, and can effectively alleviate postoperative immune function suppression, reduce LPS, AMY,ALP and promote patient recovery. 2020 Vol. 27 (19): 112-114 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 115 Effect comparison of Mametong minimally invasive rotary resection and traditional small incision on the treament of benign breast nodules TIAN Shao-lin；CHEN Bo Objective To investigate the effect of minimally invasive rotary incision and traditional small incision surgery on the treatment of benign breast nodules. Methods A total of 75 breast nodule patients admitted in our hospital from November 2018 to November 2019 were selected as the research subjects. They were divided into a reference group (38 cases) and an experimental group (37 cases) according to the lottery method. The reference group was treated with a small incision, in the traditional surgical treatment, the experimental group was treated with Mymotomy minimally invasive rotary resection. The clinical treatment effect, surgical status and hospital stay, and postoperative complications were compared between the two groups. Results The clinical treatment excellent rate in the experimental group was higher than that in the reference group, and the difference was statistically significant (P＜0.05). The intraoperative blood loss in the experimental group was lower than that in the reference group, the length of the incision was shorter than that in the reference group, and the operation time and hospital stay were shorter than those in the reference group, and the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the experimental group was lower than that in the reference group, and the difference was statistically significant (P＜0.05). Conclusion Compared with the traditional operation with small incision, the clinical effect of mammotome minimally invasive surgery for benign breast nodules is better, and it can reduce the amount of bleeding, the length of incision, the time of operation and hospitalization, and the rate of complications. 2020 Vol. 27 (19): 115-117 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 118 Correlation study between CXCR4 expression and triple negative breast cancer TANG Chao-li Objective To investigate the expression of the chemokine receptor 4 (CXCR4) in triple negative breast cancer and its relationship with the prognosis of recurrence and metastasis. Methods A total of 160 cases of triple negative breast cancer from May 2015 to January 2018 in our hospital were collected, immunohistochemistry was used to analyze the expression of CXCR4. The clinicopathological features and the relationship between CXCR4, time of disease progression and total survival were analyzed. Results There were significant differences in the age, axillary lymph nodes and disease-free survival (DFS) of CXCR4 group (P＜0.001). There were shorter DFS with age ≤45 years old, axillary lymph node positive and CXCR4 positive. The overall survival (OS) of CXCR4 positive patients was shorter than that of CXCR4 negative patients. Conclusion CXCR4 overexpression is not only a marker of tumor invasiveness, but also a marker of poor prognosis in triple negative breast cancer patients. 2020 Vol. 27 (19): 118-121 [Abstract] ( 35 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 122 Effect analysis of low-dose Decitabine combined Arubicin + Cytarabine +Recombinant Granulocyte Colony Stimulating Factor programme in the treatment of myelodysplastic syndrome JIN Meng-di；XIAO Jian-hong；WANG Dan-yu Objective To investigate and analyze the efficacy of low-dose Decitabine combined with Arubicin + Cytarabine + Recombinant Granulocyte Colony Stimulating Factor (CAG) regimen in the treatment of myelodysplastic syndrome. Methods From October 2011 to October 2018, 82 patients with myelodysplastic syndrome admitted to our hospital were selected as study subjects. They were divided into the study group (n=41) and the reference group (n=41)by the random number table method. Patients in the reference group were given conventional CAG, patients in the study group were treated with low-dose Decitabine combined CAG regimen. The clinical treatment effect of the two groups of patients was compared, and the adverse reactions of the two groups after treatment were observed. Results The remission rate of the patients in the study group was 78.05%, which was higher than that in the control group(58.54%), the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence rate of adverse reaction between the two groups (P＞0.05). Conclusion The treatment of patients with myelodysplastic syndrome with low-dose Decitabine combined with CAG is helpful to improve the clinical remission rate, and will not increase the obvious adverse reactions, and the safety is good. 2020 Vol. 27 (19): 122-124-128 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 125 Comparison of therapeutic effect between en bloc enucleation and transurethral resection of bladder tumor in the treatment of non-muscular invasive bladder tumor CHEN Jian；WEI Huai-ying；TANG Hua；YE De-chuan Objective To investigate the safety and effectiveness of en bloc enucleation in the treatment of nonmuscular invasive bladder tumor(NMIBC).Methods The clinical data of 49 patients with NMIBC who underwent surgical treatment from December 2015 to June 2019 in our hospital were retrospectively analyzed. According to different treatment methods,the patients were divided into the observation group(26 cases)and the control group(23 cases)according to different treatment methods. The observation group was treated by transurethral en bloc enucleation, and the control group was treated with transurethral resection of bladder tumor (TURBT).The operation time,intraoperative hemorrhage,postoperative complications, postoperative hospitalization time, hospitalization cost and the positive rate of the incision base were compared between the two groups. At the same time, the self-assessment of depression and anxiety were used to compare the psychological scores of the two groups after 4 weeks of treatment. Results There were no significant differences between the two groups in operation time, postoperative hospitalization time and hospitalization cost (P＞0.05). The intraoperative blood loss of patients in the observation group was less than that in the control group, and the difference was statistically significant (P＜0.05). The positive rate of pathological margin basement after operation in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05);There were no significant difference in the incidence of bladder perforation, obturator nerve reflex and postoperative bladder irritation between the two groups (P＞0.05). There were no significant difference in the psychological scores of depression and anxiety between the two groups after 4 weeks of treatment (P ＞0.05). Conclusion Compared with traditional TURBT, transurethral en bloc enucleation has the advantages of less intraoperative bleeding and lower positive rate of pathological margin after operation. It is a simple, safe, effective treatment method and worthy of clinical promotion. 2020 Vol. 27 (19): 125-128 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 129 Application of nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure after ventilator weaning in preterm infants JIANG Yun Objective To explore the application effect of nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (NCPAP) after ventilator weaning in preterm infants. Methods A total of 50 preterm infants admitted to our hospital from June 2016 to July 2019 were selected as research subjects. They were divided into control group (n=25) and an observation group (n=25) by random number table method. NCPAP was used in the control group and NIPPV was used in the observation group. After treatment, the treatment effect, indicators of blood gas analysis, recovery, and near-term and long-term complications of the two groups were compared. Results The incidence of ventilator weaning failure within 7 days after extubation,arterial carbon dioxide partial pressure(PaCO2),arterial partial pressure of oxygen (PaO2）, pH, total hospital stay, biparietal diameter (BPD), retinopathy of prematurity(ROP), and the incidence of intracranial hemorrhage of the two groups had no significant differences (P＞0.05). After treatment, the time of non-invasive ventilation and fraction of inspired oxygen (FiO2) in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion After ventilator weaning of premature infants, both NIPPV and NCPAP treatment can alleviate the hypoxic state of the infants, and the effect is remarkable. However, taking factors like the short-term and long-term complications of the infants into consideration, ventilation scheme should be appropriately chosen according to the specific conditions of the infants in clinic. If the infants′ condition allows, NIPPV can be preferentially selected to improve their quality of life. 2020 Vol. 27 (19): 129-132 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 133 Study on the influencing factors of the morbidity of female vulva white lesions WU Juan Objective To investigate the influencing factors of the morbidity of vulva white lesions in female patients.Methods The retrospective analysis was adopted. A total of 200 patients confirmed as vulva white lesions by pathological section in the hospital from January 2014 to October 2017 were selected as vulva white lesions group,and 200 healthy female relatives and friends, health check-ups or family members of inpatients who were accompanied during the same period were selected as healthy control group. The general data were recorded, and univariate and multivariate Logistic regression analysis were performed to find the influencing factors of vulva white lesions in female patients. Results There was no statistical difference in the proportion of underwear material between two groups (P＞0.05). The proportion of time daily sitting work≥6 h, spicy dietary habit, pessimistic and passive emotions, immune disease, vaginitis or urethritis, birth injury, and parity (≥2 times) in vulval white lesions group were higher than those in healthy control group(P＜0.05). The Logistic regression analysis found that time daily sitting work≥6 h, spicy dietary habit, pessimistic and passive emotions, immune disease, vaginitis or urethritis, birth injury, and parity (≥2 times) were influencing factors of vulval white lesions in female patients (OR＞1, P＜0.05). Conclusion Daily sitting work≥6 h, spicy dietary habit, pessimistic and passive emotions, etc. are risk factors that cause vulva white lesions in female patients. Clinically, it can improve their psychological state and reduce their risks of vulva white lesions by improving the working style and dietary habit. 2020 Vol. 27 (19): 133-135 [Abstract] ( 51 ) HTML (28 KB)  PDF  (0 KB)  ( 6 ) 136 Clinical effect comparison of Didroxyprogesterone and Progesterone Injection in the treatment of threatened abortion LIANG Jing-mei；ZHANG Dong-tao Objective To compare the clinical effect of Didroxyprogesterone and Progesterone Injection in the treatment of threatened abortion. Methods A total of 50 cases of threatened abortion patients admitted to our hospital from January 2018 to January 2019 were selected as the research objects. According to the method of random number table,they were divided into observation group and control group, with 25 cases in each group. The observation group was treated with Didroxyprogesterone orally, while the control group was treated with Progesterone Injection. The clinical symptom relief time, hormone level, success rate of fetal protection and adverse reactions of the two groups were compared. Results The relieving time of lumbago, abdominal pain and hemostasis in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05). Two weeks after treatment, the progesterone (P) and estradiol (E2) in the observation group were lower than those in the control group, and the levels of chorionic gonadotropin (HCG) were higher than those in the control group, the levels of P, E2 and HCG were lower than those in the control group at 4 weeks after treatment, with statistically significant differences (P＜0.05). The materni success rate of the observation group which was higher than that in the control group, with statistically significant difference (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, with statistically significant difference (P＜0.05). Conclusion The clinical effect of Dydrogesterone on threatened abortion is better than Progesterone Injection. 2020 Vol. 27 (19): 136-138 [Abstract] ( 44 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 139 Effect of Qilin Pills combined with Levocarnitine Oral Liquid treating oligospermia and asthenospermia HUANG Jun Objective To investigate the effect of Qilin Pills combined with Levocarnitine Oral Liquid treating oligospermia and asthenospermia. Methods A total of 100 patients of oligoasthenospermia who were treated in our hospital from May 2017 to March 2019 were selected. According to the principle of random control, the patients were divided into two groups, 50 cases in each group. The control group was treated with Levocarnitine Oral Liquid. The observation group was treated Levocarnitine Oral Liquid combined with Qilin Pills. The curative effect, sex hormone level and semen quality were observed. Results The total effective rate of the observation group was higher than that of the control group (P＜0.05); the levels of testosterone (T), estrogen (E2), follicle estrogen (FSH) and luteinizing hormone (LH)in the observation group were higher than those in the control group (P＜0.05); the sperm concentration, sperm survival rate, A-level sperm activity, and the level of FSH in the observation group were higher than those in the control group(P＜0.05), the activity of A+B sperm was higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Qilin Pills combined with Levocarnitine Oral Liquid is effective in the treatment of oligospermia and asthenospermia, which can effectively improve the level of sexual hormone and semen quality. 2020 Vol. 27 (19): 139-141 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 142 Effect of Nuangong Qiwei Powder combined with Vitamin E Capsules on the decline of ovarian reserve function in elderly women SU Hong-li；XIE Zhuo-jian；JIANG Jun；LIN Jin-rong Objective To explore the effect of Nuangong Qiwei Powder combined with Vitamin E Capsules in the treatment of ovarian reserve decline in women at advanced ages. Methods A total of 90 elderly women with decreased ovarian reserve function who were admitted to our hospital from June 2018 to September 2019 were selected. They were divided into control group and experimental group according to random number table method, 45 cases in each group. In the control group, Progesterone was used, while in the experimental group, Nuangong Qiwei Powder combined with Vitamin E Capsules were provided. The clinical treatment effect, and changes of luteinizing hormone (LH), follicle stimulating hormone (FSH), and estradiol (E2), serum anti-Müllerian hormone (AMH), sinus follicle number (AFC), and serum inhibin B (INHB) before treatment and 3 months after treatment were observed. Results After 3 months of treatment, the LH and FSH levels of the two groups were lower than those before treatment, and the levels of E2, AMH,AFC, INHB levels were higher than those before treatment, the levels of the LH and FSH in the experimental group were lower than those in the control group, and the levels of E2, AMH, AFC, INHB levels were higher than those in the control group, and the differences were statistically significant (P＜0.05). The total clinical response rate of the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Nuonggong Qiwei Powder combined with Vitamin E Capsules has a good effect on the reduction of ovarian reserve function in elderly women. It can not only improve the therapeutic effect and the levels of E2, AMH, AFC, but also reduce LH and FSH levels. 2020 Vol. 27 (19): 142-144--148 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 145 Comparison of clinical effect between hysteroscopic electrotomy and hysteroscopic curettage in patients with endometrial polyps OUYANG Wen；LIU Feng-ping Objective To compare the clinical effects of hysteroscopic electrotomy and hysteroscopic curettage in patients with endometrial polyps. Methods A retrospective analysis of 76 patients with endometrial polyps diagnosed based on pathological results in our hospital from January 2017 to October 2019 was selected. They were divided into control group (n=36) and observation group (n=40) according to different surgical methods. In the control group, hysteroscopic curettage was used, and in the observation group, hysteroscopic electrotomy was applied. The overall response rate, operation time, intraoperative blood loss, hospital stay, menstrual time and volume, and incidence of complications and recurrence rate were compared between the two groups. Results The overall response rate of the observation group was 95.00, which was higher than that of the control group of 80.56%, and the difference was statistically significant (P＜0.05). The amount of intraoperative bleeding in the observation group was less than that in the control group, and the operation time and hospital stay were shorter than those in the control group, with statistical differences(P＜0.05). The menstrual time of the observation group was shorter than that in the control, and the menstrual volume was less compared with the control group, with statistical differences (P＜0.05). The total complication rate and recurrence rate of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Compared with hysteroscopic curettage, hysteroscopic electrotomy has better curative effect on endometrial polyps, which can reduce surgical trauma, shorten the operation and hospital stay, improve their menstrual status and reduce the occurrence of complications. The recurrence rate is low and the safety is high, which is worthy of clinical application. 2020 Vol. 27 (19): 145-148 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 149 Clinical effect of preservative-free autologous serum eye drops in the treatment of dry eyes after femtosecond laser-assisted in situ keratomileusis YAO Tao；HE Wei Objective To evaluate the clinical effect of preservative-free autologous serum eye drops in the treatment of dry eyes after femtosecond laser-assisted in situ keratomileusis (LASIK). Methods Forty-two patients diagnosed with moderate to severe dry eyes from August 2018 to August 2019 one month after LASIK were selected as the research objects, and they were divided into the control group (21 cases, 42 eyes) and experimental group (21 cases, 42 eyes) according to the random number table method. Patients in the control group were treated with 0.1% Sodium Hyaluronate Eye Drops for routine treatment, and patients in the experimental group were treated with preservative-free autologous serum eye drops. Local eye drops were continuously treated for 28 days, and were followed up regularly at 7, 14, and 28 days after treatment. The subjective symptom (evaluated by the ocular surface disease index [OSDI]) score, tear break-up time (BUT), corneal fluorescein staining score, Schirmer I test results of the two groups of patients before and after treatment were recorded and analyzed. The incidence of adverse reactions of the two groups was observed. Results At 14 and 28 days after treatment, the OSDI scores of the patients in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). At 14 and 28 days after treatment, the BUT of the experimental group was longer than that of the control group, and the difference was statistically significant (P＜0.05). At 7, 14, and 28 days after treatment, the corneal fluorescein staining scores of the experimental group were lower than those of the control group, and the differences were statistically significant (P＜0.05). At 28 days after treatment,the amount of tears secreted in the experimental group was more than that in the control group, and the difference was statistically significant (P＜0.05). No adverse reactions occurred during the treatment in two groups. Conclusion Preservative-free autologous serum eye drops can safely and effectively treat dry eye patients after LASIK, promote corneal epithelial repair, improve the quality of tear film and relieve the subjective symptoms. 2020 Vol. 27 (19): 149-152 [Abstract] ( 48 ) HTML (40 KB)  PDF  (0 KB)  ( 8 ) 153 Randomized controlled study of Fruit Acid revitalizing and LED red and blue light in the treatment of acne vulgaris NIE Min-yan；LI Guang；WEN Xiao-yi Objective To compare and analyze the effect of Fruit Acid rejuvenation and LED red and blue light in the treatment of acne vulgaris. Methods A total of 90 patients with acne vulgaris treated in our hospital from November 2015 to May 2017 were selected and divided into three groups of A, B, and C according to the random number table method, with 30 cases in each group. Group A was treated by Fruit Acid rejuvenation combined with external rubbing Vitamin E ointment treatment, group B was treated with LED red and blue light combined with external rubbing Vitamin E ointment treatment, and group C was treated with pure external rubbing Vitamin E ointment treatment. The efficacy and the adverse reactions treatment period after 4, 8, 12, and 16 weeks were compared among the three groups.Results After 4, 8, 12, and 16 weeks of treatment, the total effective rate of treatment in group A was higher than that in group B and group C, and the total effective rate of treatment in group B was higher than that in group C, the differences were statistically significant (P＜0.05). There were no significant differences in the total effective rate of treatment in the same group after 4, 8, 12, and 16 weeks (P＞0.05). There was no significant difference in the incidence rate of adverse reactions among the three groups (P＞0.05). Conclusion Fruit Acid rejuvenation and LED red and blue light have good effect in treating acne vulgaris, but Fruit Acid rejuvenation is more effective. 2020 Vol. 27 (19): 153-155 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 156 Effect of eustachian tube balloon dilatation combined with tympanic membrane puncture and drainage in the treatment of refractory secretory otitis media TAN Xiang-gao； XU Wei-hua；DAI De；WU Hui-min Objective To investigate the effect of eustachian tube balloon dilatation combined with tympanic membrane puncture and drainage in the treatment of refractory secretory otitis media. Methods Fifty patients with refractory secretory otitis media treated in Maoming Petrochemical Hospital from March 2016 to September 2017 were selected as the research subjects. They were divided into observation group (n=25) and control group (n=25) according to the random number table method. The control group was treated with traditional methods such as eustachian tube bluffing,tympanic membrane puncture, and tube placement after local hormone treatment, and the observation group was treated with eustachian tube balloon dilatation combined with tympanic membrane puncture and drainage. The pure tone hearing threshold (PTA), air-bone conduction gap (ABG), eustachian tube manometer (TMM), and eustachian tube function score (ETS) of the two groups were compared before and after 24 months. The proportion of patients with R value of 30 mbar, R value of 40 mbar, and R value of 50 mbar before and 24 months after surgery were measured. Results After treatment, the levels of PTA and ABG in the two groups were lower than those before treatment, and the score of ETS was higher than that before treatment, the differences were statistically significant (P＜0.05). After treatment, the levels of PTA and ABG in the observation group were lower than those in the control group, the ETS score was higher than that in the control group, the differences were statistically significant (P＜0.05). After treatment, the proportion of patients with R value at 30, 40, and 50 mbar in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Traditional treatment can relieve the symptoms of patients in a short period of time. Eustachian tube balloon dilatation can make the eustachian tube obstructed again, and it can solve the obstruction of physiological ventilation function of the middle ear. The symptom improvement is obvious, the effect is lasting, the curative effect is definite, it is worth popularizing. 2020 Vol. 27 (19): 156-158-179 [Abstract] ( 41 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 159 Effect comparison of root canal and post-myelinus root canal in the treatment of pulpitis after inactivation of vital pulp ZHAO Ying-jie；ZHANG Xiao-jiao Objective To compare the effect of endodontic treatment of pulpitis after inactivation of living pulp teeth and root canal extraction. Methods A total of 86 patients with pulpitis who were admitted to our hospital from January 2017 to April 2019 were selected as the research objects. They were divided into two groups according to the time of admission, and each had 43 patients. The observation group was treated with root canal after inactivation of the living pulp teeth,and the control group was treated with root canal after extubation. The patients were followed up for 4 months after treatment, the efficacy were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05); the incidence of pain in the observation group after treatment was lower than that in the control group, the difference was statistically significant (P＜0.05); The rate of acute reaction occurred in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05); the total incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Compared with root canal treatment after pulp extraction, root canal treatment after active pulp tooth deactivation can significantly improve the efficacy of pulpitis, improve pain, and have fewer adverse reactions. 2020 Vol. 27 (19): 159-161 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 162 Application value of 128-slice spiral CT and multi-planar post-processing technology in preoperative diagnosis of gastrointestinal stromal tumor WU Ying-lan Objective To analyze the application value of 128-slice spiral CT and multi-planar (MPR) post-processing technology in preoperative diagnosis of gastrointestinal stromal tumor (GIST), so as to valuable reference for clinical diagnosis in the future. Methods From January 2017 to June 2019, 20 GIST patients confirmed by surgical pathology and immunohistochemistry were selected as the research objects. A total of 128 slice spiral CT was performed on them, and MPR post-processing technology was applied. Based on the results of pathology and immunohistochemistry, the detection of lesions, the location and qualitative results of CT and MPR post-processing technology were statistically analyzed. Results By CT and MPR post-processing technology, 13 cases of gist were located in stomach, 5 in small intestine and 2 in duodenum. There were 13 cases of mucosal appearance and 7 cases of obvious ulcer in mucosa. There were 15 cases of solid capsule and 5 cases of solidity. Enhanced scanning revealed 12 cases of uniform tumor enhancement and 8 cases of uneven enhancement. Among the patients with uniform enhancement, 11 cases were diagnosed as benign and 1 case was potentially malignant. Among the patients with uneven enhancement, the lesions were diagnosed as benign in 2 cases and malignant in 6 cases. There were no significant differences between the location and qualitative results of CT and MPR post-processing technology and pathological examination (P>0.05). Conclusion 128-slice spiral CT and MPR post-processing technology can obtain accurate localization and qualitative results, and have high clinical diagnostic accuracy, which is worthy of attention and promotion. 2020 Vol. 27 (19): 162-164 [Abstract] ( 42 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 165 Application value of MSCTU+CTA in the diagnosis of urological malignant tumor ZUO Kai-rong;CHEN Li; LI Lun-cheng;LI Zheng-xiong;DAI Hong; ZHOU Yi；LIU Yuan-bin Objctive To investigate the aoolication value of multi-slice spiral computed tomography urography and computed tomography angiography (MSCTU+CTA) in the diagnosis of urological malignant tumor. Methods A total of 55 participants with urological malignant tumor who were examined by MSCTU + CTA and ultrasound (US) in our hospital from January 2014 to September 2019 were selected as the study objects. Imaging was analyzed retrospectively,and the diagnostic efficacy of the two groups was evaluated according to the surgical and pathological results. Results Within the 55 malignant tumor, there were 18 cases with renal cell carcinomas, 3 cases with renal pelvic cancer, 2 cases with ureteral cancer, and 32 cases with bladder cancer. A total of 42 cases were diagnosed correctly, 8 cases were misdiagnosed, and 5 cases were missed by US, the accuracy of location diagnosis was 90.90% (50/55), and that of qualitative diagnosis was 76.36% (42/55). As for MSCTU+CTA, there were 50 cases diagnosed correctly, 3 cases were misdiagnosed and 2 cases were missed, the accuracy of location diagnosis was 96.36% (53/55), and that of qualitative diagnosis was 90.90% (50/55). The diagnostic accuracy of MSCTA+CTU was significantly higher than US, and the difference was statistically significant (P＜0.05). Conclusion Both MSCTU+CTA and US play important role in the diagnosis of urological malignant tumor. MSCTU+CTA is better than US in diagnostic accuracy and has significant value for clinical application. 2020 Vol. 27 (19): 165-168 [Abstract] ( 45 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 169 Retrospective study of characteristics of preoperative ultrasonography in patients with cervical lymph node metastasis of papillary thyroid carcinoma ZENG Lin-hui Objective To study the characteristics of preoperative ultrasonography in patients with cervical lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTMC). Methods From January 2016 to December 2019, the clinical data of 100 patients with PTMC confirmed by postoperative pathology in our hospital were analyzed retrospectively,31 patients developed CLNM among them. All patients underwent ultrasound examination before operation. The preoperative ultrasound examination data were analyzed.The difference between CLNM and non-CLNM preoperative ultrasound image characteristics was analyzed by univariate analysis, and the independent risk factors of CLNM were analyzed by multivariate Logistic regression. Results Univariate analysis showed that there were no significant difference between the two groups in the location, aspect ratio, shape, internal echo and internal echo components (P＞0.05). There were significant differences between the two groups in maximum diameter of cancer focus, definition of nodal boundary, microcalcification, internal blood flow signal and extracapsular invasion of thyroid (P＜0.05). The results of multivariate Logistic regression analysis showed that the maximum diameter of the cancerous foci ＞5 mm, microcalcification, and extrathyroidal invasion were independent preoperative ultrasound risk signs of CLNM (P＜0.05). Conclusion Preoperative ultrasound signs have a certain predictive value for CLNM in patients with PTMC, among which the maximum diameter of the cancerous foci ＞5 mm, microcalcification and extrathecal thyroid invasion are the high-risk features of CLNM. 2020 Vol. 27 (19): 169-171 [Abstract] ( 38 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 172 Effect of Masquelet technique combined with Yanghe Decoction in the treatment of tibial osteomyelitis HUANG Zhuang-le Objective To explore the clinical effect of Masquelet technique combined with Yanghe Decoction in the treatment of tibial osteomyelitis. Methods A total of 78 patients with tibial osteomyelitis admitted to the First Department of Trauma, Yangchun Hospital of Traditional Chinese Medicine from July 2015 to May 2016 were selected as the research objects, and they were divided into group A (n=39) and group B (n=39). Group A was treated with Masquelet technology and Yanghe Decoction, while group B was treated with Masquelet technology alone. The callus growth score,fracture healing time and complication rate of the two groups were compared. Results The callus growth score in group A was higher than that in group B at 3 months and 6 months after treatment, the differences were statistically significant (P＜0.05); the fracture healing time in group A was significantly shorter than that in group B, the difference was statistically significant (P＜0.05); the incidence rates of adverse events of lower limb deep vein thrombosis (DTV), impaired liver and kidney function, and recurrence of symptoms in group A were lower than those in group B, and the differences were statistically significant (P＜0.05). Conclusion The treatment of tibial osteomyelitis patients with Yanghe Decoction and Masquelet technique can achieve better therapeutic effect, accelerate callus growth, shorten fracture healing time, reduce complication rate and relieve patients′ discomfort. 2020 Vol. 27 (19): 172-175 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 176 Effect of Indobufen combined with Buyang Huanwu Decoction treating Qi-stagnation and blood-stasis type of cerebral infarction YAN Shu-chuan；HU Shu-yun Objecctive To investigate the clinical effect of Indobufen combined with Buyang Huanwu Decoction treating qi-stagnation and blood-stasis type of cerebral infarction. Methods From January to October 2019, 110 patients with cerebral infarction of qi-stagnation and blood-stasis type admitted to our hospital were selected as research objects. They were divided into control group (55 cases)and observation group (55 cases)according to random number table method. The control group used conventional treatment methods. The observation group used Indobufen combined with Buyang Huanwu Decoction on the basis of conventional treatment methods. The clinical effects were determined by comparing the traditional Chinese medicine (TCM) syndrome score, Barthel score, TCM curative effect and neurological function defect curative effect of the two groups of patients before and after treatment. Results There were no significant differences in TCM syndrome scores between the two groups before treatment (P＞0.05). After treatment, the TCM syndrome scores of the two groups were lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant (P＜0.05). There were no significant differences in Barthel scores between the two groups before treatment (P＞0.05). After treatment, the Barthel scores of the two groups were higher than those before treatment, and the observation group was higher than the control group, the differences were statistically significant (P＜0.05). The total effective rate of patients of efficacy of TCM in the observation group was 96.36%,which was higher than 83.64% in the control group, the difference was statistically significant (P＜0.05). In comparing neurological function defect curative effect, the total effective rate of the observation group was 92.73%, higher than that of the control group of 70.91%, and the difference was statistically significant (P＜0.05). Conclusion Indobufen combined with Buyang Huanwu Decoction treating qi-stagnation and blood-stasis type of cerebral infarction is helpful to increase the clinical effect. 2020 Vol. 27 (19): 176-179 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 180 Psychological distress and related factors of patients with primary liver cancer HE Ye；WANG Xiao-song；HU Si-jun；WANG Xing-ying；FAN Shi-lan；HUANG Fang Objective To explore the psychological distress and related factors of patients with primary liver cancer.Methods The clinical data of 450 patients with primary liver cancer admitted to our hospital from October 2018 to May 2019 were retrospectively analyzed. All patients were screened by psychological distress screening tool (DMSM) questionnaire. A total of 150 cases with the degree of pain ≥4 points were in the observation group, and 300 cases with the degree of pain less than 4 points were the control group. The related data of the two groups were compared, and the influencing factors that may cause psychological pain were recorded and analyzed. Results The results of single factor analysis indicated that there were statistically significant differences between the two groups in age, education level,sleep disorders, disease understanding, medical burden, and adverse emotions (P＜0.05); the results of multifactor analysis indicated that the age was ≥40 years old (β= 0.693, OR=2.000, 95%CI=1.330-3.008), high school education and below (β=1.012, OR=2.750, 95%CI=1.795-4.214), had sleep disturbance (β=1.323, OR=3.755, 95%CI=2.416-5.837) ,low level of disease understanding (β=1.986, OR= 7.286, 95%CI=4.053-13.097), medical burden (β=0.700, OR=2.015,95%CI=1.343-3.022), had bad emotions (β= 1.880, OR=3.279, 95%CI= 2.129-5.052) were the risk factors for the psychological pain of patients with primary liver cancer (P＜0.05). Conclusion In view of the risk factors that cause the suffering of patients with primary liver cancer, we should increase the degree of attention and take effective measures to reduce the degree of pain in patients. 2020 Vol. 27 (19): 180-182 [Abstract] ( 41 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 183 Investigation and analysis of blood glucose stability, treatment cost and the impact on quality of life of diabetes patients in primary hospital LI Li；HUANG Shao-bing；CHEN Huan-ping；LIANG Xue-qiu Objective To explore the stability of blood glucose, the cost of treatment and the impact on the quality of life of diabetes patients in primary hospitals. Methods A total of 206 patients with type 2 diabetes mellitus (T2DW) in the community from March 2017 to July 2019 were selected. The general data of patients were collected and counted,the stability of blood glucose and quality of life were evaluated, and the relevant factors affecting the stability of blood glucose and quality of life were analyzed. Results Among the 206 T2DW patients, 133 (64.56%) had stable blood glucose and 73 (35.44%) had unstable blood glucose; hypertension, hyperlipidemia, smoking, drinking, poor diet control,overweight or obesity, and never exercising were independent risk factors affecting blood sugar stability (OR≥1, P＜0.05). Among 206 T2DW patients, 146 (70.87%) had high quality of life and 60 (29.13%) had low quality of life. A total of 91 cases (44.17%) had treatment cost ＞5000 yuan and 115 cases (55.83%) had treatment cost ≤5000 yuan.Age ≥60 years old, unstable blood sugar, treatment cost ＞5000 yuan, poor diet control, overweight or obesity are independent risk factors affecting quality of life (OR≥1, P＜0.05). Conclusion Diabetes patients in primary hospitals have higher treatment costs, better blood sugar stability and higher quality of life. Hypertension, hyperlipidemia, smoking history, drinking history, poor diet control, overweight or obesity, and never exercising are independent risk factors affecting blood sugar stability, while unstable blood sugar, treatment cost ＞5000 yuan, poor diet control, overweight or obesity are independent risk factors affecting quality of life, which should be paid attention to clinically. 2020 Vol. 27 (19): 183-186 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 187 Analysis of the causes of blood discarding of voluntary blood donor in Changsha region from 2015 to 2019 ZENG Fan-zhi；CHEN Jing；DENG Ye-hua；ZHAO Fei-xue Objective To understand the causes of unqualified blood screening of voluntary unpaid blood donors in Changsha region from 2015 to 2019, looking for methods and strategies to reduce blood waste. Methods The test results of 762 845 blood samples in Changsha region from 2015 to 2019 were collected and analyzed retrospectively. Results From 2015 to 2019, the total number of voluntary blood donors in Changsha region was 762 845. The annual blood collection showed an increasing trend year by year, and the annual unqualified rate was basically flat. The total number of unqualified persons was 14 646, and the unqualified rate was 1.92%. Hepatitis B surface antigen (HBsAg)and alanine aminotransferase (ALT) were the two main factors for scrap of blood sample in the past 5 years. There were statistically significant differences in the unqualified rates of HBsAg, hepatitis C virus antibody (anti-HCV), human immunodeficiency virus antibody/antigen (anti-HIV/HIV antigen), and ALT in different years (P＜0.05). Conclusion The unqualified blood screening in Changsha region in the past 5 years is basically consistent with the epidemic trends of corresponding disease. The establishment of a low-risk and fixed blood donation team is conducive to reducing the rate of blood scrapping. In order to reduce blood scrapping due to false positives, the preliminary blood screening criteria should be strict, and reagents with better specificity should be used. 2020 Vol. 27 (19): 187-189 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 190 Results of cervical cancer screening in rural women in Pulandian district of Dalian city GUO Yan-hua Objective To investigate the prevalence of cervical cancer among rural women in Pulandian District,Dalian. Methods From June to November 2018, 6001 married women aged 35 to 64 years in 5 townships under the jurisdiction of Dalian Pulandian were selected as the research objects. Abnormal cases of cervical shedding cytology(TCT) were further diagnosed by colposcopy and histopathology, The gynecological disease detection rate was counted,and the TBS classification, age, education, and pathological diagnosis of cervical cytology in TCT-positive women were analyzed. Results The total positive rate of TCT test was 2.52% (151/6001), the detection rate of cervical cancer was 366.61/100 000 (22/6001), the detection rate of reproductive tract infection was higher, and there was no atypical scale in the diagnosis of TCT abnormality. The detection rate of squamous cell (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) were higher. TCT abnormalities were mostly concentrated in women over the age of 45 years old with low education level. Histopathology mainly manifested as low-grade cervical intraepithelial lesions and Chronic cervicitis. Conclusion To improve the awareness of rural women′s self-care and regular screening in Pulandian District of Dalian City. For rural women with low education level and over 45 years of age, we should focus on strengthening health education and cervical cancer screening. 2020 Vol. 27 (19): 190-192 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 193 Application effect of 7S lean management in medical experience of inpatients YA Li-na；YI Xiao-qing；WU Li-ni；YANG Xiao-zhen；XIAO Lin Objective To explore the application effect of 7S lean management in medical experience of inpatients.Methods Using convenient sampling method, 300 inpatients in our hospital from January 2018 to December 2019 were selected as research objects. According to the different length of stay, 150 inpatients from January to December 2018 were set as the control group, and 150 inpatients from January to December 2019 were set as the observation group.The control group adopted routine inpatient hospital management, and the observation group implemented 7S lean management on the basis of the control group. The scores of hospitalization experience, the number of questions mentioned during hospitalization and the total satisfaction of the two groups were compared. Results The scores of experience and evaluation of the patients at the time of admission, first admission of the ward, during the hospitalization treatment stage, during the hospital service work, during the medical technology service work and during the discharge procedures in the observation group were higher than those in the control group, and the differences were statistically significant(P＜0.05). The number of questions mentioned during hospitalization in the observation group was fewer than that in the control group, and the difference was statistically significant (P＜0.05). The total satisfaction of the patients in the observation group was 96.00%, which was higher than 76.00% in the control group, and the difference was statistically significant (P＜0.05). Conclusion 7S lean management can improve medical experience of inpatients and satisfaction of patients, which is worthy of clinical promotion. 2020 Vol. 27 (19): 193-195 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 196 Research on the establishment and application of clinical diagnostic coding score database based on electronic medical records WENG Zhi-xiong；YU Zhi-jin；LIN Yan-feng；LI Shao-ling；PENG Cheng-yuan；ZHOU HUA-jian；CHEN Hui-xin；YU Rong1 Based on the structured electronic medical record system of a top three general hospital in Huizhou City,Guangdong Province,the three libraries of"clinical disease diagnosis database that conforms to the logical thinking of doctors","ICD-10 disease diagnosis coding library" and "medical insurance disease score database" are combined into one. In order to standardize and unify the doctor′s disease diagnosis terminology, optimize the work flow of medical record coding personnel, prompt medical personnel to make reasonable diagnosis and treatment, and strictly control the unreasonable growth of medical expenses, with a view to satisfying hospital medical quality management, medical record information management, medical insurance payment, medical research The development needs of various aspects such as teaching provide a reference plan for the next implementation of disease diagnosis-related classification in Huizhou. 2020 Vol. 27 (19): 196-199 [Abstract] ( 31 ) HTML (39 KB)  PDF  (0 KB)  ( 10 ) 200 Influence of hospital multi-department collaboration mechanism on disciplinary inspection and supervision capabilities BIAN Yu-hang Since the 19th National Congress of the Communist Party of China, China′s disciplinary inspection and supervision has reached a new level. Adhering to the ideology of socialism with Chinese characteristics in the new era led by Xi Jinping, implementing the spirit of the 19th National Congress of the Communist Party of China and the deployment of the second plenary session of Central Commission for Discipline Inspection, and promoting the high-quality development of disciplinary inspection and supervision while ensuring stability are important tasks of the current disciplinary inspection and supervision units. In the new era, hospitals can give full play to their respective functions and carry out coordinated supervision through multi-department cooperation mechanisms to form a joint supervision force.This article mainly explains the main content of hospitals′ disciplinary inspection and supervision, and puts forward some suggestions for the problems existing in the current multi-department collaboration mechanism of hospitals. 2020 Vol. 27 (19): 200-203 [Abstract] ( 38 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 204 Emergency management of novel coronavirus infection protection in emergency department of otolaryngology ZHOU Dan-yun Corona virus disease 2019 (COVID-19) is an acute infectious pneumonia discovered for the first time,which seriously harms people′s physical and mental health. Since the outbreak in Wuhan in December 2019, the disease has spread across the country. Till March 2, 2020, 80 174 people have been infected nationwide, and the death toll has reached 2915. The COVID-19 has been evaluated by the World Health Organization as a "public health emergency of international concern". The National Health Commission of the People′s Republic of China announced that the disease was included in a Class B infectious disease, and took Class A measures to prevent and control. In order to do well in epidemic prevention and control, the Affiliated Hospital of Nantong University, according to the notice of the local health department, unified deployment arrangements after the outbreak of the COVID-19. The daily outpatient clinic of the department of otolaryngology was ceased, emergency management plan was launched, and the emergency otolaryngology service was implemented. The prevention and control work was carried out in an orderly manner. There was no infection of medical personnel or nosocomial infections, and preliminary results were achieved. This article summarizes the relevant work, so as to provide suggestions and guidance for further prevention and control of the epidemic situation. 2020 Vol. 27 (19): 204-207 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 208 Effect of routed nursing measures on intraoperative bleeding and complications in patients with inguinal hernia ZHANG Xing；WANG Chun-xia；HONG Yan Objective To study the effect of pathological nursing measures on intraoperative bleeding and complications in patients with inguinal hernia. Methods From July 2017 to August 2018, 85 patients with perioperative inguinal hernia admitted to our hospital were selected and divided into two groups according to the random number table method,43 cases in the control group and 42 cases in the observation group. The control group received routine perioperative nursing, and the observation group underwent pathological nursing measures. The patients′ intraoperative blood loss,pain duration, bed time, hospitalization time, hospitalization cost, and incidence of adverse reactions during treatment were compared between two groups. Results The intraoperative blood loss in the observation group was less than that in the control group, and the difference was statistically significant (P＜0.05). The postoperative blood loss rate in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The postoperative pain duration, the time of getting out of bed, and the length of hospital stay in the observation group were shorter than those in the control group, and the hospitalization costs was lower than that in the control group， and the differences were statistically significant (P＜0.05). The incidence of retention was lower than that of the control group,and the difference was statistically significant (P＜0.05). Conclusion The implementation of pathological nursing measures for patients with inguinal hernia during perioperative period can significantly reduce the intraoperative blood loss,shorten the postoperative recovery time and hospital stay, and reduce the incidence of postoperative complications. 2020 Vol. 27 (19): 208-210-214 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 211 Application of the concept of rapid rehabilitation surgery in the nursing of middle-aged and elderly patients with peri-hip fracture TAN Juan Objective To explore the application effect of the concept of rapid rehabilitation surgery (FTS) in the nursing of middle-aged and elderly patients with peri-hip fracture. Methods A total of 68 middle-aged and elderly patients with peri-hip fracture in our hospital from January 2017 to December 2018 were selected. They were divided into control group and observation group by nursing mode,34 cases in each group.The control group was adopted routine nursing and routine follow-up after discharge. The observation group was adopted FTS nursing and extended nursing after discharge. Functional rehabilitation, postoperative complications, hospitalization days and quality of life were compared between the two groups. Results The rehabilitation score of the observation group at discharge and 1 month after discharge were higher than those of the control group, and the length of hospitalization was shorter than that in the control group, with statistical differences (P＜0.05); the Barthel index of the observation group at discharge and 1 month after discharge were higher than those of the control group,with statistical differences (P＜0.05); the total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant(P＜0.05). Conclusion In the nursing of middle-aged and elderly patients with peri-hip fracture, nursing under the guidance of the concept of FTS nursing can effectively improve the functional rehabilitation of patients, shorten the length of hospital stay, reduce the incidence of complications and improve the living ability, worthy of clinical application. 2020 Vol. 27 (19): 211-214 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 215 Application effect of volume-viscosity swallowing test on food management in patients with stroke and dysphagia LIN Yan-hua Objective To explore the application effect of volume viscosity swallowing test (V-VST) in the management of swallowing in stroke patients with dysphagia. Methods From January to December 2019, 60 stroke patients with dysphagia who had EAT-10 ≥3 points and improved Wada drinking water test gradeⅡ-Ⅲwere selected as the study objects, and were divided into observation group and control group according to random number table method, 30 cases in each group. The patients in the control group adopted the routine feeding management, including psychological nursing management, diet management, swallowing rehabilitation exercise and oral care. On the basis of routine feeding management, the observation group adopted the V-VST test results to guide the food characters and the amount of one mouthful, and developed a personalized feeding management plan. The incidence of aspiration errors, stroke-related pneumonia and quality of life of dysphagia patients were compared before and after intervention. Results The incidence of aspiration errors and stroke-related pneumonia in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05). After intervention, the quality of life score of dysphagia in the two groups was lower than that before intervention, the quality of life score of dysphagia in the observation group was lower than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The food safety management scheme based on the V-VST test results of patients with stroke dysphagia can reduce the incidence of aspiration and stroke-related pneumonia, and significantly improve the quality of life of patients with stroke dysphagia. 2020 Vol. 27 (19): 215-217 [Abstract] ( 32 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 218 Application effect of modified gastric tube in patients with food poisoning ZHONG lu-hua；CHEN Zuo-he；XIAO Shi-gui；HUANG Yu-juan Objective To study the application effect of modified gastric tube in patients with food poisoning. Methods Fifty-six cases of food poisoning patients admitted to our hospital from September 2018 to November 2019 were selected. According to the principle of random control, they were divided into the control group and the research group,28 cases in each group. Routine gastric tube washing was used in the control group, the research group was used modified gastric tube. Gastric lavage time, tube blocking times, gastric lavage time, complications and changes in heart rate and systolic blood pressure before and after intubation were compared between the two groups. Results The number of intubation and tube blocking in the research group were less than those in the control group, the gastric lavage time in the research group was (43.96±10.03) min, which was shorter than that in the control group of (56.23±11.23) min, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group (7.14%)was lower than that in the control group (35.71%), the difference was statistically significant (P＜0.05). Changes of heart rate and systolic blood pressure in the research group after intubation were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The improvement of gastric tube can effectively reduce the rate of tube blockage, shorten the time of gastric lavage and improve the clinical effect. 2020 Vol. 27 (19): 218-220 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 221 Effect of analgesia delivery combined with free posture delivery nursing on delivery outcome of primiparas ZHENG Hui Objective To analyze the value of analgesia delivery combined with free posture delivery nursing in primiparas with vaginal delivery. Methods A total of 268 primiparas with vaginal delivery who met the standard in our hospital from March 2016 to July 2018 were selected, and they were divided into control group and research group according to the random number table method, 134 cases in each group. The control group received analgesia delivery, while research group was given free posture delivery based on control group, and was given reasonable nursing intervention during delivery. The time of each stage of labor, pain degree and delivery outcome were compared between the two groups. Results There were 64 cases of pain degree with 0-2 during delivery in research group and 39 cases in control group, and research group was more than control group, and the difference was statistically significant (Z=3.612, P＜0.001). The time of first to third stage of labor and total stages of labor in research group ([6.12±1.51] h, [1.01±0.31] h,[7.88±1.59] min, [7.69±1.62] h) were shorter than those in control group ([9.01±1.79] h, [1.79±0.29] h, [12.61±2.89] min,[11.01±1.78] h), and the differences were statistically significant (t=21.758, 21.270, 16.600, 15.968, P＜0.001). The incidence of postpartum hemorrhage rate, conversion to cesarean section and neonatal asphyxia in research group (0.75%,1.49%, 0.75%) were lower than those in control group (5.97%, 8.96%, 5.97%), and the differences were statistically significant (χ2=4.139, 7.537, 4.139, P＜0.05). Conclusion Analgesia delivery combined with free posture delivery for primiparas with vaginal delivery is better than simple analgesia delivery, it can shorten the time of stages of labor, relieve delivery pain, reduce the incidence of postpartum hemorrhage and neonatal asphyxia, and increase the safety of delivery. 2020 Vol. 27 (19): 221-223-227 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 224 Application of disposable infusion tube exhaust smoke method in endoscopic surgery WU Xiao-feng；HUANG Xiao-ming；ZHAN Fang；XIAO Huan Objective To explore the clinical application effect of one-time infusion tube smoke exhaust method in endoscopic surgery. Methods From March 2016 to November 2018, 50 patients who were scheduled to undergo laparoscopic surgery in our hospital were selected as the study objects. They were divided into control group and observation group by random number table method, 25 cases in each group. Patients in both groups were treated with conventional laparoscopic radical surgery for colorectal cancer, while patients in the control group were treated with traditional smoke exhaust method, while patients in the observation group were treated with one-off infusion tube smoke exhaust method. The operation condition, image definition, CO2 concentration, surgeon satisfaction and air cleanliness before and after operation were compared between the two groups. Results The total time of operation in the observation group was shorter than that in the control group, and the amount of bleeding was less than that in the control group, the differences were statistically significant (P＜0.05). The scores of intraoperative image definition and surgeon satisfaction in the observation group were higher than those in the control group, the intraoperative CO2 concentration was lower than that of the control group, the differences were statistically significant (P＜0.05). The number of dust particles with diameter of 0.3, 0.5, 1.0, 3.0 and 5.0 μm in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion The method of one-time infusion pipe exhaust smoke can ensure the continuity of operation, shorten the operation time, improve the image clarity and the air cleanliness of the operating room, which is worthy of clinical recommendation. 2020 Vol. 27 (19): 224-227 [Abstract] ( 41 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 228 Application study of toilet habit nursing in elderly patients with myocardial infarction ZHU Min Objective To investigate the effect of customary lavatory nursing in elderly patients with myocardial infarction (AMI). Methods From February 2017 to February 2018, 108 patients with AMI treated in our hospital were selected as the research objects, according to the number of single and double method, they were divided into control groups and observation group, 54 cases in each group. The control group was given routine disease nursing,the observation group in the control group on the basis of toilet habits to carry out nursing, two groups of toilet habits scores, adverse reactions occur, the quality of life score and nursing satisfaction were compared. Results In the observation group, the scores of defecation difficulty, fecal shape, defecation sensation and defecation times were lower than those of the control group, with statistical differences (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The scores of physical function, emotional function, role function, social function and cognitive function of the observation group were higher than those of the control group, and the nursing total satisfaction was higher than that of the control group, with statistical differences (P＜0.05). Conclusion The implementation of toilet habit nursing in elderly patients with AMI can correct the bad toilet habit, reduce the occurrence of adverse reactions, improve the quality of life and nursing satisfaction of patients. 2020 Vol. 27 (19): 228-230 [Abstract] ( 49 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 231 Application effect of evidence-based nursing in patients undergoing anorectal operation HOU Miao；JIANG Li Objective To probe into the application effect of evidence-based nursing in anorectal operation. Methods A total of 100 patients with anorectal surgery from September 2018 to September 2019 in our hospital were selected and divided into two groups according to the pattern of odd and even numbers. The control group (n=50) carried out routine nursing, while the study group (n=50) carried out evidence-based nursing, and recorded the recovery indexes such as anal exhaust time, bowel sound recovery time, first defecation time and hospitalization time, the maximal urinary flow rate (MRF) and bladder residual urine volume (BPH) were calculated, and the patients′ satisfaction with nursing was evaluated by self-designed satisfaction questionnaire. Results The anal exhaust time, bowel sounds recovery time， first defecation time and hospital stay time in the study group were shorter than those in the control group,with statistical differences (P＜0.05). The residual urine volume of bladder in the study group was (48.67±23.11) ml,which was less than that in the control group of (79.86±24.38) ml, with statistical difference (P＜0.05). The maximal urinary flow rate was (14.36±4.34) ml/s in the study group, which was higher than that in the control group of (12.65±4.12) ml/s, with statistical difference (P＜0.05). The nursing total satisfaction of the patients in the study group was 96.00%, higher than that of the control group (82.00%), with statistical difference (P＜0.05). Conclusion Evidencebased nursing intervention in anorectal surgery can shorten the treatment time, promote the recovery of patients after surgery, and have positive significance for the prevention of dysuria, worthy of clinical application. 2020 Vol. 27 (19): 231-233 [Abstract] ( 38 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 234 Effect of precise nursing intervention on hypertension patients′ blood pressure and treatment compliance SUN Hong-yun Objective To analyze the effect of precise nursing intervention on hypertension patients′ blood pressure and treatment compliance. Methods A total of 102 cases hypertensive patients admitted to our hospital from January 2018 to June 2019 were selected, they were divided into control group and observation group according to odd even number grouping method, 51 cases in each group. The control group received routine clinical care, the observation group used precision nursing intervention, the blood pressure level, quality of life and treatment compliance of the two groups were compared. Results After the intervention, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the observation group were lower than those in the control group (P＜0.05). The scores of physical function, psychological state, social interaction, self-care ability and other quality of life indicators in the observation group were higher than those in the control group (P＜0.05). The scores of medication compliance, diet compliance, exercise compliance, healthy living behavior and other treatment compliance indicators in the observation group were higher than those in the control group, with statistical differences (P＜0.05). Conclusion Using precise nursing intervention in patients with hypertension can reasonably control their blood pressure level, improve treatment compliance and improve quality of life. 2020 Vol. 27 (19): 234-236 [Abstract] ( 47 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 237 Clinical application effect of continuous nursing intervention in children epilepsy WANG Ting-ting Objective To explore the clinical application effect of continuous nursing intervention in children epilepsy.Methods From January 2017 to November 2018, 68 children hospitalized in our hospital due to epilepsy were selected as the study objects. According to the random number table method, the childrens were divided into observation group and control group, 34 cases in each group. The control group was given routine discharge nursing guidance, and the observation group was given continuous nursing intervention on the basis of the control group. After different nursing intervention, the parents′ understanding of the medical knowledge related to epilepsy, the readmission rate and nursing satisfaction of the two groups were observed. Results There were no significant differences between the two groups of the scores of parents′ health education and satisfaction before intervention (P＞0.05). The patients in the observation group were followed up for 3, 6 and 12 months by telephone or outpatient. The re-hospitalization rate of the observation group was lower than those of the control group, and the length of stay was shorter than that of the control group, the differences were statistically significant (P＜0.05). The satisfaction and health education scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Continuous nursing intervention can reduce the number of re-hospitalization of epileptic children, shorten the length of hospitalization, improve parents′ cognition of the disease, improve patients′ satisfaction, and provide effective measures for out of hospital nursing and treatment. 2020 Vol. 27 (19): 237-239 [Abstract] ( 48 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 240 Application effect of comprehensive rehabilitation nursing in initially hospitalized female schizophrenia patients LI Liu-jin Objective To discuss the application effect of comprehensive rehabilitation nursing in initially hospitalized female schizophrenia patients. Methods A total of 65 initially hospitalized female schizophrenia patients admitted from January 2017 to October 2019 in our hospital were selected as research subjects. According to random number table method, patients were divided into control group (n=33) and observation group (n=32). The routine nursing was performed in the control group; on the basis of the former, the comprehensive rehabilitation nursing was performed in the observation group. Before and after intervention, the brief psychiatric rating scale (BPRS) scores, insight and treatment attitude questionnaire (ITAQ) scores and nursing satisfaction were compared between two groups. Results There were no significant between-group differences in BPRS, ITAQ scores and medicine-taking compliance before intervention(P＞0.05); after intervention, BPRS scores in the observation group were lower than those of control group, ITAQ scores and medication compliance were higher than those of control group, the differences were statistically significant (P＜0.05); the nursing total satisfaction in the observation group was higher than that of control group, with statistical difference (P＜0.05). Conclusion For initially hospitalized female schizophrenia patients, the comprehensive rehabilitation nursing can improve their insight, nursing satisfaction and medication compliance. It is worthy of application. 2020 Vol. 27 (19): 240-242-246 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 243 Application of comprehensive nursing intervention in patients with mechanical ventilation in intensive care unit CHENG Ying Objective To explore the application of comprehensive nursing intervention in patients with mechanical ventilation in intensive care unit. Methods From October 2018 to August 2019, 88 patients with mechanical ventilation in our hospital intensive care unit (ICU) were selected. According to the random number table method, the patients were divided into control group (n=44) and observation group (n=44). The control group received routine nursing intervention, while the observation group received comprehensive nursing intervention. The incidence of ventilator-associated pneumonia, inflammatory indexes and total incidence of adverse reactions were compared between the two groups.Results The total incidence of ventilator-associated pneumonia in the observation group was lower than that in the control group, with statistical difference (P＜0.05). The levels of procalcitonin, leukocyte count and C-reactive protein in the observation group were lower than those in the control group, with statistical differences (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, with statistical difference(P＜0.05). Conclusion Comprehensive nursing intervention for patients with mechanical ventilation in ICU can significantly reduce the incidence of ventilator-associated pneumonia, improve the level of inflammatory factors, and reduce the risk of adverse reactions. 2020 Vol. 27 (19): 243-246 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 247 Intervention effect of comprehensive nursing management on falls of elderly patients with mental disorders LIU Zhen；DONG Xian-miao；XIE Ji-qun；XU Qu；OUYANG Xiao-fen Objective To analyze the intervention effect of comprehensive nursing management on falls in elderly patients with mental disorders. Methods A total of 90 elderly patients with mental disorders admitted to our hospital from April 2017 to April 2019 were selected as the study objects. The patients were divided into the basic group (from April 2017 to March 2018) and the comprehensive group (from April 2018 to April 2019) according to the different admission time, 45 cases in each group. The basic group of patients were given conventional nursing management, comprehensive group of patients were given comprehensive nursing management. The quality of life (QLQ-C30) of the patients in the two groups was analyzed and compared, and the incidence of falls and the satisfaction of family members′ nursing were observed. Results After the nursing management, the QLQ-C30 scores of the patients in the comprehensive group were higher than those in the basic group; the fall rate of the patients in the comprehensive group (2.22%) was lower than that in the basic group (17.78%); the nursing total satisfaction of the family members (95.56%) was higher than that in the basic group (82.22%), the differences were statistically significant (P＜0.05). Conclusion Applying the comprehensive nursing management mode to the elderly patients with mental disorders can effectively reduce the incidence of falls and improve the quality of life and the nursing satisfaction of family members. 2020 Vol. 27 (19): 247-249 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 250 Application effect of comprehensive nursing in patients with cirrhotic ascites YANG Shun Objective To explore the application effect of comprehensive nursing in cirrhotic ascites patients. Methods A total of 80 patients with cirrhotic ascites admitted to our hospital from June 2017 to June 2019 were selected as the research objects. According to the random number table method, they were divided into the control group and the research group, 40 cases in each group. The control group was given routine nursing, while the research group was given comprehensive nursing. Results After nursing, the indexes of liver function of glutamic-oxalacetic transaminase (AST)and glutamic-pyruvic transaminase (ALT) in the two groups were lower than those before nursing, and albumin (ALB)was higher than that before nursing, the differences were statistically significant (P＜0.05). After nursing, AST and ALT liver function indexes in the research group were lower than those in the control group, and ALB was higher than that in the control group, with statistical differences (P＜0.05). The clinical efficacy of nursing care in the research group(95.00%) was higher than that in the control group (77.50%), and the difference was statistically significant (P＜0.05).Conclusion Comprehensive nursing intervention for cirrhotic ascites patients can improve the clinical treatment effect,significantly improve the indicators of cirrhosis, and improve the prognosis of patients with positive effects, it is worthy of clinical promotion. 2020 Vol. 27 (19): 250-252 [Abstract] ( 41 ) HTML (29 KB)  PDF  (0 KB)  ( 7 )

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