经鼻间歇指令通气与经鼻持续正压通气在早产儿撤机后的应用

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Abstract Objective To explore the application effect of nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (NCPAP) after ventilator weaning in preterm infants. Methods A total of 50 preterm infants admitted to our hospital from June 2016 to July 2019 were selected as research subjects. They were divided into control group (n=25) and an observation group (n=25) by random number table method. NCPAP was used in the control group and NIPPV was used in the observation group. After treatment, the treatment effect, indicators of blood gas analysis, recovery, and near-term and long-term complications of the two groups were compared. Results The incidence of ventilator weaning failure within 7 days after extubation,arterial carbon dioxide partial pressure(PaCO2),arterial partial pressure of oxygen (PaO2）, pH, total hospital stay, biparietal diameter (BPD), retinopathy of prematurity(ROP), and the incidence of intracranial hemorrhage of the two groups had no significant differences (P＞0.05). After treatment, the time of non-invasive ventilation and fraction of inspired oxygen (FiO2) in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion After ventilator weaning of premature infants, both NIPPV and NCPAP treatment can alleviate the hypoxic state of the infants, and the effect is remarkable. However, taking factors like the short-term and long-term complications of the infants into consideration, ventilation scheme should be appropriately chosen according to the specific conditions of the infants in clinic. If the infants′ condition allows, NIPPV can be preferentially selected to improve their quality of life.

Key words： Premature infant Nasal intermittent positive pressure ventilation Nasal continuous positive airway pressure Complications

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JIANG Yun. Application of nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure after ventilator weaning in preterm infants[J]. 中国当代医药, 2020, 27(19): 129-132.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I19/129

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