前列地尔治疗早期糖尿病肾病的临床效果

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Abstract Objective To investigate the clinical effect of Alprostadil Injection on microalbuminuria in early diabetic nephropathy (DN). Methods A total of 180 patients with early DN admitted to our hospital from June 2016 to June 2019 were selected as subjects, and divided into the treatment group (90 cases) and the control group (90 cases) according to the random number table. Patients in both groups were given conventional treatment. The control group was given oral Huangkui Capsules on the basis of conventional treatment. The treatment group was treated with intravenous Alprostadil Injection on the basis of the control group. The therapeutic course was 4 weeks in the two groups of patients. The total treatment efficiency of the two groups of patients after treatment was compared. Blood urea nitrogen(BUN), serum creatinine (SCr), glycosylated hemoglobin (HbA1c) and 24 h microalbumin (mAlb) were compared before and after treatment between the two groups. The incidence of adverse reactions after treatment between the two groups was compared. Results The total effective rate of treatment group was higher than that in the control group, the difference was statistically significant (P＜0.05). The mAlb, BUN, SCr and HbA1c after treatment in the treatment group were lower than those before treatment, while mAlb, BUN, SCr and HbA1c after treatment in treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in adverse reactions of two groups (P＞0.05). Conclusion Alprostadil combined with Huangkui Capsule for the treatment of patients with early DN can effectively improve clinical curative effect , decrease 24 h mAlb, delay renal function injury and be suitable for clinical application.

Key words： Diabetic nephropathy Alprostadil Huangkui Capsule Microalbuminuria Creatinine Urea nitrogen

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	Articles by authors
	ZHANG Qi-fen
	YANG Ming-min
	XIONG Yan
	ZHOU Hai-xing
	YU Ying

Cite this article:

ZHANG Qi-fen,YANG Ming-min,XIONG Yan, et al. Clinical effect of Alprostadil on the treatment of early diabetic nephropathy[J]. 中国当代医药, 2020, 27(19): 88-90-94.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I19/88

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