急性脑梗死患者静脉溶栓前中性粒细胞百分比与溶栓后临床结局的关系

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Abstract Objective To explore the relationship between the percentage of neutrophils before intravenous thrombolysis and clinical outcome after thrombolysis in patients with acute cerebral infarction. Methods A retrospective analysis of 118 patients with acute cerebral infarction who received intravenous thrombolysis in department of neurology in our hospital from August 2017 to August 2019. Early neurological deterioration was defined as at 24 h after thrombolysis the National Institutes of Health Stroke scale (NIHSS) score increased by ≥4 points before thrombolysis, and the poor prognosis was defined as a modified Rankin score of 3 months ＞2 points. Binary Logistic regression was used to analyze the independent risk factors of early neurological deterioration, poor prognosis and death within 3 months. Results There were 18 patients (15.3%) had early neurological deterioration, 55 patients (46.6%) had poor prognosis, and 23 patients (19.5%) died within 3 months. Logistic regression analysis showed that the percentage of neutrophils (OR=1.058, 95%CI=1.006-1.112) and NIHSS score before thrombolysis (OR=1.099, 95%CI=1.019-1.186) were independent risk factors for early neurological deterioration (P＜0.05); after correcting NIHSS score (OR=1.251, 95%CI= 1.145-1.366), the percentage of neutrophils (OR= 1.049, 95%CI=1.009-1.091) was still an independent risk factor for poor prognosis within 3 months (P＜0.05); atrial fibrillation (OR=3.600, 95%CI=1.079-12.017), percentage of neutrophils(OR=1.068, 95%CI=1.012-1.127) and NIHSS score before thrombolysis (OR=1.177,95%CI=1.068-1.297)were independent risk factors for death within 3 months after thrombolysis (P＜0.05). Conclusion The percentage of neutrophils before intravenous thrombolysis in patients with acute cerebral infarction has a certain predictive value for the clinical outcome after intravenous thrombolysis.

Key words： Acute ischemic stroke Intravenous thrombolysis Outcome Neutrophil

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	LIU Chang
	DONG Meng
	LIU Ji-hong
	ZOU Jia-lin
	DONG Jun

Cite this article:

LIU Chang,DONG Meng,LIU Ji-hong, et al. The relationship between neutrophil ratio before thrombolysis of acute ischemic stroke patients and their clinical outcome after thrombolysis[J]. 中国当代医药, 2020, 27(19): 77-80.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I19/77

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