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Quick Search     Adv Search 2021 Vol. 28, No. 8 Published: 2021-03-18   4 Fingerprint and multicomponent quantitative analysis of Banxia Baizhu Tianma Decoction by HPLC WANG Shu-ling;YANG Hui-min;LI Min-hui;XU Nan;MEN Lian-hui; WANG Yue;GU Yu-xin;BAI Xue;TIAN Chao Objective To establish HPLC fingerprint of Banxia Baizhu Tianma Decoction, and simultaneously determine the contents of seven components (gastrodin, liquiritin, naringin, hesperidin, isoliquiritin, atractylodes lactone Ⅲ, glycyrrhetinic acid).To provide the basis for the quality control of Banxia Baizhu Tianma Decoction.Methods The separation was carried out on an Inert Sustain C18 column (250 mm×4.6 mm, 5 μm).The mobile phase was acetonitrile-water solution, gradient elution was used.Volume flow rate was 1.0 mL/min.Detection wavelength was 254 nm.Column temperature was 30 ℃.HPLC fingerprints of 18 batches of Banxia Baizhu Tianma Decoction samples were established,the similarity was evaluated.The common peaks were assigned and identified, and the quantity of components identified was determined.Results The similarity of fingerprints of the control and 18 batches of samples were greater than 0.983.And 25 common peaks were calibrated, including 2 from Pinellia Ternata, 1 from Gastrodia Elata, 6 from Atractylodes Macrocephala, 6 from Exocarpium Citri Rubrum, 2 from Poria Cocos and 5 from Glycyrrhiza Uralensis Fisch, of which 2 common peaks could not be clearly identified.Peak 8 was gastrodin.Peak 14 was liquiritin.Peak 15 was naringin.Peak 16 was hesperidin.Peak 19 was isoliquiritin.Peak 21 was atractylodes lactone Ⅲ.Peak 25 was glycyrrhetinic acid.Contents of the seven components respectively were: gastrodin 2.1933-5.0626 mg/g, liquiritin 0.1220-0.2867 mg/g, naringin 7.3165-15.8486 mg/g, hesperidin 0.1301-0.3928 mg/g, isoliquiritin 0.1733-0.4524 mg/g, atractylodes lactone Ⅲ0.2361-0.7849 mg/g, glycyrrhetinic acid 0.0180-0.0372 mg/g.Conclusion HPLC fingerprint and quantitative determination method of Banxia Baizhu Tianma Decoction have merits of good repeatability and stability, which provide the reference for quality control and evaluation. 2021 Vol. 28 (8): 4-8转17 [Abstract] ( 47 ) HTML (46 KB)  PDF  (0 KB)  ( 9 ) 9 Effect of triptolide on human renal carcinoma A498 cells proliferation,migration and invasion CAO Bo；FU Gang；WANG Xiao-min；CHAI Chun-xiang；ZHANG Zhao-guang；CHEN Xue-xun ective To investigate the effect of triptolide on the proliferation, migration and invasion of human renal carcinoma A498 cells.Methods A498 cells exposed to different concentrations of triptolide.The concentrations of triptolide were 0, 200, and 400 nmol/L, which were defined as control group, low-dose group and high-dose group.Western Blot was used for testing the expressions of AKT, p-AKT, MTOR and p-MTOR in A498 cells, and the proliferation, migration and invasion were evaluated.Results The expressions of p-AKT and p-MTOR in the low-dose group and highdose group were lower than those in the control group, the expressions of p-AKT and p-MTOR in the high-dose group were lower than those in the low-dose group, and the differences were statistically significant (P＜0.05).The proliferation,migration and invasion ability of A498 cells in the low-dose group and high-dose group were lower than those of the control group, the proliferation, migration and invasion ability of A498 cells in the high-dose group were lower than those of the low-dose group, and the differences were statistically significant (P＜0.05).Conclusion Triptolide can inhibit the proliferation, migration and invasion of A498 cells by blocking the PI3K/AKT/mTOR signal pathway. 2021 Vol. 28 (8): 9-12 [Abstract] ( 43 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 13 Effect comparison of non-fusion stable elastic rod fixation system and nucleus pulposus removal intervertebral fusion pedicle screw rod fixation system in the treatment of lumbar degeneration YEJun；WANGHai-tao Objective To compare the effect of non-fusion stable elastic rod fixation system and nucleus pulposus removal intervertebral fusion pedicle screw rod fixation system in the treatment of lumbar degeneration.Methods A total of 40 patients with severe lumbar degeneration who required surgery in Fuyong People′s Hospital of Bao′an District in Shenzhen City from December 2016 to June 2018 were selected as the research objects.They were divided into the dynamic fixation group and the fusion fixation group according to the random lottery method, with 20 cases in each group.Patients in the dynamic fixation group were treated with pedicle elastic rod internal fixation system without removing the nucleus pulposus, and patients in the fusion fixation group were routinely treated with nucleus pulposus removal intervertebral fusion pedicle screw rod system internal fixation.The visual analogue scale (VAS) of low back pain, lower extremity pain, the Oswestry dysfunction (ODI) index and overall lumbar spine mobility before and after surgery, and incidence of postoperative complications were compared between the two groups.Results All 40 patients successfully completed the operation and were followed up after the operation.There were no statistically significant differences in the VAS score, ODI index and the overall lumbar spine mobility between the two groups at three days after operation(P＞0.05).At six months after operation, the VAS score and ODI index of the dynamic fixation group were lower than those of the fusion fixation group, the differences were statistically significant (P＜0.05).At 12 and 18 months after surgery, there were no significant differences in the VAS score and ODI index between the two groups (P＞0.05).At 6,12, and 18 months after surgery, the overall lumbar spine mobility of the dynamic fixation group was higher than that of the fusion fixation group, and the difference was statistically significant (P＜0.05).The lumbar spine pain, function and mobility were improved in the two groups at 6, 12, and 18 months after surgery compared with this group at three days after surgery, and the differences were statistically significant (P＜0.05).No serious complications occurred in both groups.Conclusion Both the non-fusion stable elastic rod fixation system and the nucleus pulposus removal intervertebral fusion pedicle screw rod fixation system are effective surgical methods for the treatment of lumbar degeneration,and they can achieve good surgical results.The dynamic fixation group has the advantages of rapid relief of pain, quick recovery of overall postoperative lumbar spine mobility, large postoperative lumbar spine overall mobility, reduced incidence of degeneration of adjacent segments, and rehydration of nucleus pulposus after surgery.But the dynamic fixed group also has stress and deformation of elastic rods. 2021 Vol. 28 (8): 13-17 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 18 Effect of mild acute normovolemic hemodilution with different fluids on indicators of hemodynamics, blood gas and thrombelastogram indicators of lumbar spinal fusion patients ZHU Hai-tao ；WANG Dan-dan； FENG Guang-ju Objective To investigate the effect of mild acute normovolemic hemodilution (ANH) with different fluids on indicators of hemodynamics, blood gas and thrombelastogram indicators of lumbar spinal fusion patients.Methods A total of 50 patients who underwent lumbar spinal fusion under general anesthesia in Huazhong University of Science and Technology Union Shenzhen Hospital from August 2017 to December 2019 were selected as the research subjects.The patients were divided into the hydroxyethyl starch group and the compound sodium chloride group by the random number table method, with 25 patients in each group.The two groups were treated with Hydroxyethyl Starch 130/0.4 and Compound Sodium Chloride Solution for ANH, respectively, and the hematocrit was expected to be 30% after dilution.The changes of indicators of hemodynamics, blood gas and thrombelastogram of patients in the two groups were observed before and after blood dilution.Results There were no significant differences in blood oxygen saturation(SpO2), heart rate (HR) and mean arterial pressure (MAP) 5 min before mild ANH (T1) and 15 min after mild ANH (T2)between the two groups (P＞0.05).There were no statistically significant differences in SpO2, HR and MAP at T2 in the two groups compared with those at T1 (P＞0.05).Among the indicators of thromboelastic diagram, K value at T2 in the hydroxyethyl starch group was higher than that in the compound sodium chloride group, and Angle was lower than that in the compound sodium chloride group, the differences were statistically significant (P＜0.05).The reaction time (R)value of the hydroxyethyl starch group at T2 was higher than that at T1, and its Angle was lower than that at T1, with statistical significance (P ＜0.05).There were no significant differences in coagulation time (K) and maximum clot strength (MA) at T2 in the hydroxyethyl starch group compared with those at T1 (P＞0.05).The R value and K value of the compound sodium chloride group at T2 were lower than those at T1, and the differences were statistically significant(P＜0.05).The Angle at T2 in compound sodium chloride group was higher than that at T1 in this group, and the difference was statistically significant (P＜0.05).There was no significant difference in MA value at T2 in the compound sodium chloride group compared with that at T1 (P＞0.05).There was no significant difference in the pH value at T2 of the two groups compared with that at T1 (P＞0.05).The hematocrit at T2 in the two groups was lower than that at T1, with statistical significance (P＜0.05).The level of lactic acid at T2 in the hydroxyethyl starch group was lower than that at T1,and the difference was statistically significant (P＜0.05).There was no significant difference between the lactate level at T2 and T1 in the compound sodium chloride group (P＞0.05).Conclusion In mild ANH, the uses of Hydroxyethyl Starch 130/0.4 and Compound Sodium Chloride do not significantly affect the hemodynamics of the patients.The use of Hydroxyethyl Starch 130/0.4 will direct the coagulation function of the patients to hypocoagulability, while the use of Compound Sodium Chloride will direct the coagulation function to hypercoagulability.The lactic acid level can be reduced after the use of Hydroxyethyl Starch 130/0.4. 2021 Vol. 28 (8): 18-22转26 [Abstract] ( 41 ) HTML (49 KB)  PDF  (0 KB)  ( 8 ) 23 Analysis of NTRK1 gene mutation in a family with neonatal congenital insensitivity to pain with anhidrosis and follow-up YU Mu-xue；PAN Si-nian；FENG Jia-li；LI Shu；HU Yi-xin Objective To analyze neurotrophic tyrosine kinase receptor type 1 (NTRKl) gene mutation in a family with neonatal onset congenital insensitivity to pain with anhidrosis (CIPA) and to follow-up the neonate.Methods The male proband was born in the First Affiliated Hospital, Sun Yat-sen University in February 2018, who had a history of recurrent episodes of unexplained fever after 12 hours.Blood samples were collected from the proband and his patients.Sanger sequencing for all the exons and splicing sites of NTRK1 was performed on all samples.Follow-up of the proband was performed.Results Sanger sequencing demonstrated compound heterozygous mutations in NTRK1 for the proband.One mutation c.447_450dupTCTG (p.His151fs) was found in the proband′s father, and the other mutation c.287+2dupT was found in the proband′s mother.The proband had manifestations including fever, anhidrosis, self-mutilating behavior (biting of fingers), psychomotor retardation, and premature loss of primary teeth, growth retardation and microcephaly also were noted over the 28-month follow-up period.Conclusion The gene mutation spectrum and clinical manifestations of neonatal CIPA are expanded. 2021 Vol. 28 (8): 23-26 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 27 A case of intrahepatic biliary cystadenoma WU Jin-ke；ZENG Chao；LI Xiao-fang Intrahepatic biliary cystadenoma (IBC) is a benign tumor with low incidence, unknown etiology and lack of specificity in clinical symptoms.It is easy to be confused with liver diseases such as liver cyst, liver abscess and liver echinococcosis.IBC progresses slowly, but is at risk of malignant transformation.The principle of treatment is early surgical removal of the tumor completely.A case of IBC was reported retrospectively.Ultrasound examination of the abdomen in this case revealed cystic tumor, anechoic areas in the liver, contains multiple separate liquid dark areas and light bands floating.Pathological examination revealed that the cyst wall was composed of fibrotic tissue, with local ovarioid stroma and a single layer of cubic/columnar epithelium.It was consistent with a mucinous cystadenoma of the bile duct.To report the image and diagnosis and treatment analysis of this case, aim to improve the understanding of IBC and reduce the incidence of misdiagnosis. 2021 Vol. 28 (8): 27-29转33 [Abstract] ( 56 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 30 Research progress in etiology of polycystic ovary syndrome HU Xin-yi；AN Li-feng Polycystic ovary syndrome (PCOS) is the most common reason of reproductive endocrine dysfunction and anovulatory infertility for adolescent girls and women in childbearing age.It′s one of the clinical refractory gynecological diseases.There are various etiopathogenisis of it, and the pathogenesis is complex.Both of them are not clear.At present, PCOS not only affects menstrual cycle and fertility, but also leads to long-dated metabolic complications and even malignant tumor.Therefore, this paper reviews the etiology of PCOS, in odder to provide the new ideas for the drug discovery, diagnose and therapy of PCOS from the origin. 2021 Vol. 28 (8): 30-33 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 34 A review on influencing factors of breastfeeding among obstetric staffs HE Yue-fang；YANG Jia-rong；YANG Ting-ting；YE Si-yi；YU Meng-ting It has been previously proved that breast milk, as the natural food for infans, is rich in well-proportioned nutrients and easy to be absorbed.Breastfeeding can not only reduce the incidence of various diseases of infants and young children, but also promote their growth and cognitive development.It′s also beneficial for mothers and the society.This review mainly summarizes the influencing factors of obstetric staffs′ breastfeeding attitude and practice from three aspects, breastfeeding knowledge, self-efficacy and social support.And the practical advice for breastfeeding promotion is also suggested.Hopefully this review can provide valuable information for the further investigation on the influencing factors of breastfeeding attitude and behavior of obstetric staffs and the interventional studies to promote bteastfeeding among them. 2021 Vol. 28 (8): 34-36 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 37 Progress of Lumbrokinase for the treatment of ischemic stroke XIAO Qiu-ping；ZUO Ke-xuan；LI Ying-meng；ZHENG Long-jin；HE He-chu；LIU Wen-jun Lumbrokinase (LK) is purifed from earthworm and pertained serine protein.It could directly and indirectly degrade fibrin to promote thrombolysis and prevent formation of thrombus by defibrating and lowering blood viscosity due to pharmacological activity of plasminogen activator and plasmin.At present, LK used in thrombotic diseases is proved effective and safe, especially ischemic stroke.Combined with basic treatment, LK can improve hemorheology in patients with acute ischemic stroke, reduce fibrinogen content, improve neurological function score and quality of life,and it has a good and safe curative effect.Besides, LK could decrease recurrence rate of ischemic stroke with Aspirin.Therefore, LK has certain potential in the treatment and prevention of ischemic stroke.To provide theoretical support for further development and utilization of LK, this paper summarizes pharmacological activity and clinical application of ischemic stroke. 2021 Vol. 28 (8): 37-40 [Abstract] ( 51 ) HTML (40 KB)  PDF  (0 KB)  ( 8 ) 41 Diagnosis and treatment analysis of media ear cholesteatoma and complication based on imaging ZHAO Lian-hui Combined with clinical experience, this paper expounds cholesteatoma of media ear, and analyzes the high resolution CT (HRCT) diagnosis of tympanic orifice lesions, the extent of bone destruction, cholesteatoma of media ear in of media ear and acquired primary cholesteatoma in middle ear and mastoiditis, so as to evaluate the specific application characteristics of imaging.CT can accurately diagnose cholesteatoma of media ear and its complications, and can accurately reflect the clinical characteristics of cholesteatoma o media ear.Therefore, it is necessary to increase the application of CT in clinic.However, there are some misunderstandings in the diagnosis of facial nerve in cholesteatoma of media ear.It is easy to be confused with granulomatous of media ear, middle ear tuberculosis and middle ear malignant tumor.Therefore, it is necessary for clinical medical staff to combine various factors for diagnosis, so as to improve the diagnosis rate. 2021 Vol. 28 (8): 41-47转51 [Abstract] ( 51 ) HTML (41 KB)  PDF  (0 KB)  ( 7 ) 45 Effect of Sacubatril Valsartan Sodium Tablets combined with Spironolactone on oxidative stress and vascular endothelial function in patients with chronic heart failure ZHENG Wen；ZHANG Yuan-ya；LI Dong-fang；LIAO Ling；LIU Fan Objective To investigate the effect of Sacubatril Valsartan Sodium Tablets combined with Spironolactone on chronic heart failure (CHF).Methods A total of 80 CHF patients who were treated in Shangrao People′s Hospital from April 2017 to November 2019 were selected as the research objects and divided into the control group and the observation group according to random number table method, with 40 cases in each group.The control group was treated with Spironolactone, and the observation group was treated with Sacubatril Valsartan Sodium Tablets combined with Spironolactone.The clinical effect, cardiac function, oxidative stress, vascular endothelial function and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).There were no significant differences in the levels of superoxide dismutase (SOD), propylene glycol (MDA), left ventricular ejection fraction(LVEF), resistin, endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP) between the two groups before treatment (P＞0.05).After treatment, SOD, LVEF and CGRP levels in the two groups were higher than those before treatment,and observation group was higher than control group,the differences were statistically significant(P＜0.05).After treatment,the levels of resistin,ET-1 and MDA in the two groups were lower than those before treatment,and the observation group was lower than the control group, the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The treatment of CHF patients with Sacubitril Valsartan Sodium Tablets combined with Spironolactone has relatively good efficacy, which can effectively improve cardiac function, vascular endothelial function and oxidative stress and with certain safety. 2021 Vol. 28 (8): 45-47转51 [Abstract] ( 75 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 48 Effect of Pregabalin combined with Mecobalamin on neuropathic pain and adverse reactions in patients with herpes zoster GAO Jun-ming；ZHAO Min；WANG Dong-mei；ZUO Xu；WANG Qi Objective To investigate the effect of Pregabalin combined with Mecobalamin on neuropathic pain and adverse reactions in patients with herpes zoster, and to provide a basis for the clinical application of this therapy.Methods The clinical data of 82 patients with herpes zoster admitted to Liaoyou Baoshihua Hospital in Panjin from February 2019 to June 2020 were retrospectively analyzed.According to different treatment methods, they were divided into the observation group and the control group, with 41 cases in each group.The control group was treated with Mecobalamine, and the observation group was treated with Mecobalamine combined with Pregabalin.Neuropathic pain (visual analogue scale [VAS]score), inflammatory markers (interleukin [IL]-6, IL-8, C-reactive protein [CRP]) levels before and 2 weeks after treatment, and adverse reactions (sleepiness, fatigue, dizziness, nausea) during treatment were compared between the two groups.Results There was no significant difference in VAS score between the two groups before treatment (P＞0.05).The VAS scores in the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the VAS score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences in the levels of IL-6, IL-8 and CRP between the two groups (P＞0.05).After treatment, the levels of IL-6, IL-8 and CRP in the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the levels of IL-6, IL-8 and CRP in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Pregabalin combined with Mecobalamin has a significant effect on the treatment of herpes zoster, which can effectively reduce the degree of neuropathic pain and improve the inflammatory response of patients, and the medication is safer. 2021 Vol. 28 (8): 48-51 [Abstract] ( 84 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 52 Clinical effect of Budesonide combined with Doxofylline in the treatment of chronic obstructive pulmonary disease JIA Tie-gang；NIE Qing-rong Objective To investigate the clinical effect of Budesonide combined with Doxofylline in the treatment of chronic obstructive pulmonary disease.Methods A total of 90 patients with chronic obstructive pulmonary disease admitted to Liangxiang Hospital of Fangshan District, Beijing from May 2017 to June 2019 were selected as the research objects.According to random number table method, they were divided into the observation group and the control group,with 45 cases in each group.The observation group was given Budesonide combined with Doxotheophylline, while the control group was given routine treatment, the treatment period was 10 d.The therapeutic effect, pulmonary function indexes, arterial blood gas indexes and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.78%, which was higher than that of the control group(68.89%), and the difference was statistically significant (P＜0.05).There were no significant differences in forced expiratory volume in one second (FEV1) and forced expiratory volume in one second/forced vital capacity (FEV1/FVC) between the two groups before treatment (P＞0.05).After treatment, FEV1 and FEV1/FVC in the two groups were higher than those before treatment, FEV1 and FEV1/FVC in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Before treatment, there were no significant differences in blood oxygen partial pressure (PaO2) and arterial carbon dioxide partial pressure (PaCO2) between the two groups (P＞0.05).After treatment, PaO2 levels in two groups were higher than those before treatment, PaCO2 levels were lower than those before treatment, PaO2 in the observation group was higher than that in the control group, PaCO2 was lower than that in the control group, and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was 6.67%, which was lower than that in control group (22.22%), and the difference was statistically significant (P＜0.05).Conclusion Budesonide combined with Doxofylline can be used for the treatment of chronic obstructive pulmonary disease with fewer adverse events.It is safe and has clinical application value. 2021 Vol. 28 (8): 52-54转58 [Abstract] ( 49 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 55 Correlation between micro-inflammation status and nutritional status and cardiac function in maintenance hemodialysis patients with end-stage renal disease FU Zhi-hui Objective To explore the relationship between the micro-inflammatory state of maintenance hemodialysis in patients with end-stage renal disease (ESRD) and heart failure, nutritional status, and cardiac function.Methods Clinical data of 60 patients with ESRD admitted to the First People′s Hospital of Fuzhou City, Jiangxi Province from February 2018 to April 2020 were retrospectively analyzed.According to different treatment methods, the patients were divided into two groups: 30 patients receiving maintenance HD were treated as the HD group, and 30 patients without dialysis were treated as the non-dialysis group.30 healthy people who underwent physical examination in First People′s Hospital of Fuzhou City, Jiangxi Province were selected as the control group.According to the New York Heart Association cardiac function (NYHA) classification standard classification method, 60 patients with ESRD were rated Ⅱ20 cases,Ⅲ23 cases,Ⅳ17 cases.Fastening venous blood of each group was collected,and its C-reactive protein(CRP),hemoglobin (Hb), albumin (ALB), urea nitrogen (BUN), serum creatinine (SCr), B-type natriuretic peptide (BNP), serum iron (SF), etc., and the left ventricular ejection fraction (LVEF) of the three groups was measured by cardiac color Doppler ultrasonography.Results The CRP levels in the non-dialysis group and HD group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The CRP level in HD group was higher than that in non-dialysis group, and the difference was statistically significant (P＜0.05).There was no correlation between CRP level and SF and SCr level in non-dialysis group and HD group (r=0.16, 0.24, P＞0.05).The CRP level in ESRD patients was negatively correlated with ALB and HB (r=-0.50,-0.36, P＜0.05).The levels of CRP and BNP in the grade Ⅱgroup were lower than those in the grade Ⅲand Ⅳgroups, and the differences were statistically significant (P＜0.05).The levels of CRP and BNP in the grade Ⅲgroup were lower than those in the grade Ⅳgroup,and the differences were statistically significant (P＜0.05).The LVEF of the grade Ⅱgroup was higher than that of the grade Ⅲand Ⅳgroup, and the differences were statistically significant (P＜0.05).The LVEF of the grade Ⅲgroup was higher than that of the grade Ⅳgroup, and the differences were statistically significant (P＜0.05).The CRP level in ESRD patients was negatively correlated with LVEF (r=-0.36, P＜0.05), and positively correlated with plasma BNP (r=0.58, P＜0.05).Conclusion For ESRD patients and heart failure, most of them present in a micro-inflammatory state,and this state is closely related to malnutrition and cardiac function. 2021 Vol. 28 (8): 55-58 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 59 Correlation analysis of red blood distribution width levels with blood pressure variability in patients with prim-ary hypertension LIU Jian-feng；ZHOU Zhi-min；GAO Chao-ming；WU Yi Objective To analyze the correlation of red blood distribution width (RDW) levels with blood pressure variability (BPV) in patients with primary hypertension.Methods Retrospective analysis was made on the clinical data of 220 patients with essential in Beijing Xicheng District Pingan Hospital from October 2017 to June 2019.24 hours ambulatory blood pressure monitoring was conducted.Plasma levels of RDW, fasting blood glucose and lipids were also examined.Patients were divided into 4 groups based on their RDW levels: group Ⅰwith 58 cases (RDW＜12.4%),group Ⅱwith 56 cases (12.4%≤RDW＜12.9%), group Ⅲwith 52 cases (12.9%≤RDW＜13.5%), group Ⅳwith 54 cases (RDW≥13.5%).In this study, the standard deviation of 2-hour ambulatory blood pressure reading was used as the index of BPV, including 24 hours systolic blood pressure standard deviation (24 h SSD), 24 hours diastolic blood pressure standard deviation (24 h DSD).The BPV of patients with different RDW levels was compared and the correlation between RDW and BPV was analyzed.Results Comparison of BPV indicators showed that the levels of 24 h SSD and 24 h DSD of group Ⅳwere higher than those of the group Ⅲ, the levels of 24 h SSD and 24 h DSD of groupⅢwere higher than those of the group Ⅱ, and the levels of 24 h SSD and 24 h DSD of group Ⅱwere higher than those of the group Ⅰ, and the differences were statistically significant (P＜0.05).The result of Pearson correlation analysis showed that RDW was positively correlated with 24 hours SSD and 24 hours DSD (r=0.727 and 0.557, P＜0.05).Conclusion The RDW level of patients with essential hypertension is positively correlated with BPV, RDW is closely related to BPV in patients with essential hypertension. 2021 Vol. 28 (8): 59-61转65 [Abstract] ( 53 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 62 Effect of Levocarnitine injection before dialysis on protein energy consumption and bone metabolism in patients with diabetic nephropathy WU Yu；SUN Xiao-mei Objective To investigate the effect of the application of Levocarnitine on protein energy expenditure (PEW)and bone metabolism of patients with diabetic nephropathy hemodialysis before dialysis.Methods Clinical data of 70 patients with diabetic nephropathy undergoing hemodialysis admitted to Iron Coal General Hospital of Liaoning Health Industry Group from October 2016 to October 2018 were retrospectively analyzed.The patients were divided into the observation group and the control group according to whether Levocarnitine was used before dialysis, with 35 patients in each group.Patients in both groups were treated with high-throughput dialysis.Patients in the control group were not treated with Levocarnitine, and patients in the observation group were given Levocarnitine injection 1.0 g 15 min before each dialysis.The PEW related indexes and bone metabolism indexes before and after treatment were compared between the two groups.Results After treatment, the levels of pre-albumin (PA), albumin (ALB), cholesterol and lean body weight in the observation group were higher than those before treatment, and the levels of C-reactive protein(CRP), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C)in the observation group were lower than those before treatment, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in hemoglobin level in the observation group before and after treatment (P＞0.05).The level of TG in control group after treatment was lower than that before treatment, and the difference was statistically significant (P＜0.05).After treatment, the levels of PA, lean body weight and ALB in the observation group were higher than those in the control group, while the levels of CRP and LDL-C in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).After treatment,there were no significant differences in the levels of hemoglobin, cholesterol, HDL-C and TG between the two groups(P＞0.05).After treatment, the level of parathyroid hormone in the observation group was lower than that in the control group, the level of 25-hydroxyvitamin D3 in the observation group was higher than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of Levocarnitine before hemodialysis in diabetic nephropathy hemodialysis patients can improve PEW and bone metabolism disorders, and is suitable for clinical application. 2021 Vol. 28 (8): 62-65 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 66 Clinical study on the switching timing of sequential treatment of non-invasive and invasive mechanical ventilation XU Jin-quan；GANG Li；ZHANG Xin-li Objective To explore the switching time of sequential with non-invasive and invasive mechanical ventilation.Methods A total of 80 cases with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to Zhongshan Hospital from January 2019 to May 2020 were selected as research objects and divided into two groups according to random number table method, with 40 cases in each group.The control group was treated with experience, while the observation group was treated with the switch point between invasive breathing and non-invasive breathing in the control window of lung infection.The levels of inflammation-related factors, pulmonary function, St.George′s respiratory questionnaire (SGRQ) scores before and after treatment and complications of the two groups were compared, the main complications included ventilator-associated pneumonia, pneumothorax and heart failure.Results The levels of tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) in the observation group were lower than those in the control group after treatment, and the differences were statistically significant (P＜0.05).The levels of forced expiratory volume in one second (FEV1) and forced expiratory volume in one second／forced vital capacity (FEV1/FVC) in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The SGRQ scores of the two groups were lower than those at 48 h and 7 d after treatment before treatment, the SGRQ score of the observation group was lower than that of the control group, and the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of pulmonary infection control window as the switching point can effectively reduce the inflammatory response, improve respiratory function and reduce the complications incidence with noninvasive-invasive ventilator sequentially. 2021 Vol. 28 (8): 66-69 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 70 Preliminary study on mechanical stimulation to improve knee joint function CHEN Ke；CHEN Ming Knee osteoarthritis (KOA) is a common clinical disease, especially in the middle-aged and elderly people.Among them, articular cartilage damage and degeneration are important factors in the occurrence of knee osteoarthritis,which often cause knee joint pain and dysfunction.In severe cases, joint deformation may affect the daily activities of patients.Based on the biomechanical properties of articular cartilage and the low self-repair ability, it is of great significance to study the improvement of knee joint function in patients with KOA.This article discusses the possible mechanism of mechanical stimulation affecting articular cartilage tissue repair and improving knee joint function from the aspects of the effects and ways of mechanical stimulation affecting cartilage cells, as well as understanding the clinical application of mechanical stimulation. 2021 Vol. 28 (8): 70-73 [Abstract] ( 48 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 74 Clinical effect comparison of Kirschner wire internal fixation and mini plate internal fixation in the treatment of Bennett fracture ZHOU Jin Objective To explore the clinical effect of Kirschner wire internal fixation and mini plate internal fixation in the treatment of Bennett fracture, and provide an important reference for clinical studies.Methods Clinical data of Bennett fracture patients admitted to Department of Hand and Foot Surgery, Pulandian District Central Hospital of Dalian City from January 2019 to January 2020 were retrospectively analyzed.A total of 69 patients who received Kirschner wire internal fixation were randomly selected, and 73 patients whose propensity score matched the micro plate internal fixation.The related indicators of surgery such as operation time, intraoperative blood loss, fracture healing time and hospital stay, the excellent and good rate of surgery and postoperative recovery were compared between the two groups.Results The length of hospital stay and fracture healing time of patients in the microplate internal fixation group were shorter than those in the Kirschner wire internal fixation group, the upper limb function assessment form (DASH) scores at 4 and 8 months after discharge were lower than those in the Kirschner wire internal fixation group, the excellent and good rates of surgery was higher than that in the Kirschner wire internal fixation group, and the differences were statistically significant (P＜0.05).There were no significant differences in operative time and intraoperative blood loss between the two groups (P＞0.05).Conclusion Mini plate internal fixation in the treatment of Bennett fractures has less hospitalization time than Kirschner wire internal fixation, faster fracture healing, and obvious short-term effects.The long-term effects need further clinical exploration. 2021 Vol. 28 (8): 74-76 [Abstract] ( 55 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 77 Application effect of whole body vibration training combined with exercise therapy in knee osteoarthritis ZHANG Yi；QIN Jia-wei；HE Ze-xiang；WU Li-jian；LIN Yi-heng；LIN Qiu-xiang Objective To investigate the effect of whole body vibration training combined with exercise therapy in the treatment of knee osteoarthritis, so as to provide guidance for clinical conservative treatment.Methods A total of 32 patients with knee osteoarthritis who had received rehabilitation in Quanzhou First Hospital Affiliated to Fujian Medical University from January 2018 to December 2019 were selected as study subjects.They were divided into observation group and control group by random number table method, with 16 patients in each group.Both groups received conventional rehabilitation therapy, the control group was treated with exercise therapy on this basis, and the observation group was treated with whole body vibration training combined with exercise therapy.After 8 weeks of treatment, visual analogue scale (VAS) score, the Western Ontario and McMaster Universities osteoarthritis (WOMAC) index were compared between the two groups.Results After 8 weeks of treatment, the VAS score and WOMAC index of two groups were lower than those before treatment, with statistical significance (P＜0.05).After treatment, WOMAC index of observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).There was no significant difference in VAS score between the two groups after treatment (P＞0.05).Conclusion Whole body vibration training combined with exercise therapy has a good effect in the treatment of knee osteoarthritis, which can significantly improve the pain and knee function of patients 2021 Vol. 28 (8): 77-80 [Abstract] ( 40 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 81 Effect and safety of Anlotinib combined with chemotherapy in the treatment of non-small cell lung cancer WANG Xiao-zhou；LI Hong-shi；YU Xi WANG Zi-ying；HE Li-jie Objective To explore the effect and safety of Anlotinib combined with chemotherapy in the treatment of non-small cell lung cancer (NSCLC).Methods A total of 57 patients with advanced NSCLC (third-line) diagnosed by the First Department of Oncology, People′s Hospital of Liaoning Province from July 2018 to January 2019 were selected as the research objects, and the patients were divided into observation group (29 cases) and control group (28 cases) by the random number table method.The control group was treated with conventional chemotherapy and symptomatic treatment, and the observation group was given oral Anlotinib Hydrochloride Capsules 12 mg/(times·d) for two weeks on the basis of conventional chemotherapy, with one week of withdrawal, three weeks as a treatment cycle, and the efficacy was evaluated at the sixth week.The clinical efficacy, survival indicators and incidence of adverse reactions were compared between the two groups.Results The disease control rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The progression-free survival of the observation group was longer than that of the control group, and the difference was statistically significant (P＜0.05).The overall survival in the observation group was longer than that in the control group, and the difference was statistically significant(P＜0.05).The main adverse reactions were abnormal liver function, anorexia, nausea and vomiting, leukopenia, abnormal renal function, thrombocytopenia, fatigue, diarrhea and bleeding.There was no statistically significant difference in the incidence rate of adverse reactions between the two groups (P ＞0.05).Conclusion Anrotinib combined with chemotherapy for the treatment of NSCLC can effectively control the development of the disease, prolong the survival time of patients, and has good safety. 2021 Vol. 28 (8): 81-83转88 [Abstract] ( 56 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 84 Clinical application of Olanzapine in preventing nausea and vomiting caused by chemotherapy in patients with advanced non-small cell lung cancer WANG Lei；WANG Ming-ji Objective To investigate the clinical effect and safety of Olanzapine in preventing nausea and vomiting caused by chemotherapy in patients with advanced non-small cell lung cancer.Methods A total of 50 patients with advanced non-small cell lung cancer chemotherapy-induced nausea and vomiting in Dalian Friendship Hospital from November 2016 to November 2019 were selected, and they were divided into the observation group (n=25) and the control group (n=25) by the random number table method.Both groups were given Cisplatin combined with Paclitaxel/Docetaxel chemotherapy.Patients in the control group were treated with Ondansetron Hydrochloride Injection preventively,and in the observation group, they were treated with Olanzapine combined with Ondansetron Hydrochloride Injection to stop vomiting.The complete remission rate of nausea and vomiting after chemotherapy was recorded.The quality of life and incidence of adverse reactions between the two groups were compared.Results There was no significant difference in the complete remission rate of acute nausea and acute vomiting between the two groups (P＞0.05).The complete remission rates of delayed nausea and delayed vomiting in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The emotional function score on the quality of life scale of the observation group was higher than that of the control group, and the difference was statistically significant(P＜0.05).The nausea, vomiting and decreased appetite scores on the quality of life scale of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).The incidence of drowsiness and dizziness in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Olanzapine has a good effect on preventing delayed nausea and vomiting caused by chemotherapy in patients with advanced nonsmall cell lung cancer, and it can improve the quality of life of patients. 2021 Vol. 28 (8): 84-88 [Abstract] ( 49 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 89 Application effect of information support based on transtheoretical model in patients with breast cancer undergoing chemotherapy GUO Qiong-ping Objective To explore the application effect of information support based on transtheoretical model in patients with breast cancer undergoing chemotherapy.Methods A total of 73 patients with breast cancer who received chemotherapy admitted to Putian Medical District, No.900 Hospital of Joint Support Force from January 2018 to November 2019 were selected as research subjects.They were divided into the control group (n=36, routine intervention) and the observation group (n=37, information support based on transtheoretical model) by the random number table method.The strategies used by patients to promote health (SUPPH), compliance of rehabilitation behavior, and disability of arm shoulder and hand (DASH) scores before and after intervention were observed in the two groups.Results After intervention, the SUPPH score of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).The compliance of rehabilitation behavior in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).The DASH score of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05).Conclusion The application of information support based on transtheoretical model in breast cancer patients undergoing chemotherapy can increase patients′ confidence in treatment, benefit awareness of rehabilitation training, and strengthen the recovery of affected limbs, which is worthy of further research and promotion. 2021 Vol. 28 (8): 89-91转95 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 92 Application effect of modified blindfold on the prevention of falling during blue light irradiation for newborns LI Ting；YAN Ji-chun；LI Rong；OUYANG Yan；WANG Fei Objective To analyze the preventive effect of the modified blindfold on the falling during the blue light irradiation in the treatment of newborns.Methods A total of 78 children with neonatal jaundice who were treated in the First Affiliated Hospital of Gannan Medical University from August 2018 to February 2019 were selected as the research objects.They were all treated with blue light irradiation and divided into two groups according to the lottery method.The 41 cases in group A used modified blindfold, and 37 cases in group B used conventional blindfold.The fall-off rate of blindfold, the incidence of adverse reactions, the comfort score and the total bilirubin levels before and after treatment were compared.Results The fall-off rate of blindfold in group A (12.20%) was lower than that in group B (32.43%), and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in group A(14.63%) was lower than that in group B (35.14%), and the difference was statistically significant (P＜0.05).The comfort scores of group A were lower than those of group B, and the differences were statistically significant (P＜0.05).Before treatment, the total bilirubin levels of the two groups were not significantly different (P＞0.05).After treatment, the total bilirubin level of group A was lower than that of group B,the difference was statistically significant (P＜0.05).Conclusion The use of modified blindfold for blue light irradiation in neonates can reduce the fall of blindfold, has fewer adverse reactions, and can improve the comfort of children, thereby promoting the resolution of jaundice. 2021 Vol. 28 (8): 92-95 [Abstract] ( 55 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 96 Effect of prophylactic use of antibiotics on outcomes of perinatal infants in pregnant women with positive Group B streptococcus HUANG Wei Objective To explore the effect of prophylactic use of antibiotics on the outcomes of perinatal infants in pregnant women with positive Group B streptococcus (GBS).Methods A total of 48 patients from October 2019 to April 2020 who were positive for GBS detection by fluorescent labeling polymerase chain amplification (PCR) in Guangzhou Women and Children′s Medical Center were selected as observation group and were given antibiotic prophylaxis, and 52 cases with negative PCR detection were selected as control group.The pregnancy outcomes of pregnant women and outcomes of perinatal infants were compared between the two groups.Results There were no significant differences in the incidence rates of premature rupture of membranes, premature delivery and late abortion between the two groups(P＞0.05).There was no significant difference in postpartum hemorrhage volume between the two groups (P＞0.05).The time of postpartum lochia in the observation group was longer than that in the control group, the volume of lochia was more than that in the control group, and the incidence rate of puerperal infection was higher than that in the control group (16.67% vs.1.92%), with statistically significant differences (P＜0.05).The incidence rates of fetal distress, intrauterine vertical infection, neonatal asphyxia and postpartum horizontal infection in the observation group were 12.5%,14.58%, 10.42% and 8.33%, higher than those in the control group accounting for 1.92%, 1.92%, 0.00% and 0.00%,with statistically significant differences (P＜0.05).There were no significant differences in the incidence rates of jaundice and pneumonia between the two groups (P＞0.05).Conclusion Prophylactic use of antibiotics can improve delivery outcomes and neonatal outcomes in pregnant women with positive GBS. 2021 Vol. 28 (8): 96-98 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 99 Rehabilitation effect of pelvic floor muscle training in female patients with pelvic floor dysfunction CHEN Jing-si Objective To explore the clinical rehabilitation effect of pelvic floor muscle training in female pelvic floor dysfunction.Methods A total of 100 female patients with pelvic floor dysfunction who received treatment in Shenyang Maternal and Child Health Hospital from July 1, 2018 to December 31, 2019 were selected as the study subjects.According to the random number table method, the subjects were divided into the control group and the observation group,50 cases in each group.The Patients in the control group received only routine rehabilitation measures, and the observation group adopted pelvic floor muscle training on the basis of the control group.The score of pelvic floor myoelectric activity, normal pelvic floor muscle strength and life quality score were compared between the two groups.Results The score of pelvic floor myoelectric activity, normal rate of muscle strength and life quality score in the observation group were all higher than those in the control group, with statistically significant differences (P＜0.05).Conclusion The pelvic floor muscle training for female patients with pelvic floor dysfunction has significant clinical rehabilitation effect,it can improve the electrical activity of pelvic floor muscle, promote the strength of pelvic floor muscle to return to normal, and thus improve the quality of life. 2021 Vol. 28 (8): 99-101 [Abstract] ( 36 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 102 Effect and safety of different maintenance doses of Caffeine Citrate in the treatment of premature infants with gestational age ＜34 weeks with apnea HUANG Yao Objective To explore the effect and safety of different maintenance doses of Caffeine Citrate in the treatment of premature infants with gestational age ＜34 weeks with apnea.Methods A total of 80 premature infants with apnea less than 34 weeks of gestational age admitted to Yingtan People′ Hospital from February 2019 to February 2020 were selected as the research objects and divided into the control group and the observation group according to the random number table method, with 40 patients in each group.Both groups were treated with Caffeine Citrate as a therapeutic agent.The dosage of the control group was 5 mg/(kg·d), and the dose of the observation group was 10 mg/(kg·d).The total effective rate, treatment time, number of apnea at different stages and the probability of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The mechanical ventilation time, low-flow oxygen ventilation time and hospital stay time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).The number of apnea after 24, 48, 72 hours in the observation group was fewer than that in the control group, and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The maintenance dose of 10 mg/(kg·d) of Caffeine Citrate is more effective in the treatment of premature infants with apnea ＜34 weeks of gestational age and less adverse reactions. 2021 Vol. 28 (8): 102-104 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 105 Application effect of cognitive behavior therapy in reducing uterine contraction pain by intramuscular injection of Oxytocin after cesarean section ZHANGNan Objective To explore the application effect of cognitive behavior therapy (CBT) in reducing uterine contraction pain by intramuscular injection of Oxytocin after cesarean section.Methods A total of 200 cases of intramuscular Oxytocin injection after cesarean section in Dalian Maternal and Child Health Care Hospital from April to November 2019 were selected as the research objects and divided into the control group and the intervention group according to random number method, with 100 cases in each group.The control group was given routine nursing care,while the intervention group received CBT on the basis of routine nursing care.The pain and comfort of the two groups were compared.Results The contractions pain (visual analogue scale [VAS]score) of the intervention group was lower than that of the control group, the comfort condition (general comfort questionnaire [GCQ]score) of the intervention group was higher than that of the control group, and the differences were statistically significant (P＜0.05).The pain of intramuscular injection of Oxytocin (faces pain scale revised [FPS-R]score) in the intervention group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion CBT can reduce the severity of pain caused by intramuscular injection of Oxytocin after cesarean section, relieving uterine contraction pain,improving comfort. 2021 Vol. 28 (8): 105-107转111 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 108 Effect of transcutaneous electrical nerve stimulation combined with endorphin regimen and technique treatment on women with chronic pelvic pain syndrome and its influence on sexual life LIU Xiao-lin；ZHANG Hua-lin Objective To explore the effect of transcutaneous electrical nerve stimulation (TEN′S) combined with endorphin regimen and technique treatment on women with chronic pelvic pain syndrome (CPPS) and its influence on sexual life.Methods A total of 96 patients with CPPS admitted to Tai′an City Maternity and Child Care Hospital from May 2018 to May 2020 were selected as the research objects and divided into the control group (48 cases) and the treatment group (48 cases).The control group adopted pure technique treatment,and the treatment group adopted TEN′S+ endorphins solution + technique treatment.The clinical efficacy, visual analogue scale (VAS) score, incidence of pelvic dysfunction, and female sexual function index (FSFI) score were compared between the two groups.Results The total clinical efficiency of the treatment group was higher than that of the control group, and the difference was statistically significant (P＜0.05).After 2 courses of treatment, the VAS score of the treatment group was lower than that of the control group, and the difference was statistically significant (P＜0.05).After 2 courses of treatment, the FSFI score in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The total incidence of pelvic dysfunction in experimental group was lower than that in control group and the difference was statistically significant (P＜0.05).Conclusion TEN′S combined with endorphin regimen and technique treatment can effectively improve pain symptoms and sexual quality in CPPS patients, and reduce incidence of pelvic dysfunction.It is worth popularizing and applying. 2021 Vol. 28 (8): 108-111 [Abstract] ( 52 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 112 Clinical analysis of 19 patients with carotid artery stenosis first diagnosed with ocular symptoms TANG Yu；BAI Jing Objective To analyze the ophthalmological diagnosis and treatment results of carotid artery stenosis patients first diagnosed with ocular symptoms, in order to reduce the missed diagnosis of carotid artery stenosis, improve the prognosis of patients, and improve the quality of life of patients.Methods A total of 19 patients (19 eyes) who were admitted to the Ophthalmology Department of Dalian Municipal Central Hospital from January 2018 to November 2020 due to ocular symptoms and were later diagnosed with carotid artery stenosis were retrospectively selected.All patients underwent routine ophthalmological examination, fundus fluorescent-contrast examination, and color ultrasonography of carotid artery and retrobulbular vessels.The ophthalmological examination, carotid artery stenosis grading, treatment and prognosis of the patients were analyzed.Results There were 15 cases of sudden decline of monocular vision, 2 cases of transient amaurosis, 2 cases of vision loss with eye pain.There were 10 cases of retinal vein occlusion, 2 cases of retinal artery occlusion, 3 cases of ocular ischemic syndrome (including 2 cases with neovascular glaucoma), 2 cases of anterior ischemic optic neuropathy, and 2 cases of transient amaurosis without specific ophthalmic diagnosis.Carotid artery stenosis classification, carotid stenosis was 30%-50% in 2 cases, 51%-70% in 9 cases and 71%-99% in 8 cases.In ophthalmology department, symptomatic treatments such as improving microcirculation and vasodilating were given.Patients with carotid artery stenosis that did not meet the surgical intervention criteria were given oral drugs.After surgical intervention, the visual prognosis was not significantly improved, but fluorescene angiography showed that the arm-retinal circulation time was improved.Conclusion Patients with carotid artery stenosis can be first diagnosed in ophthalmology due to ocular symptoms.Therefore, great attention should be paid to timely screening to avoid missed diagnosis, reduce systemic complications and improve the quality of life of patients. 2021 Vol. 28 (8): 112-114转118 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 115 Clinical effect of Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel in the treatment of meibomian gland dysfunction xerophthalmia KANG Bin；WAN Jin-lan Objective To investigate the clinical effect of Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel in the treatment of meibomian gland dysfunction（MGD）xerophthalmia.Methods A total of 311 cases (622 eyes) of MGD patients with xerophthalmia who visited the outpatient department of Jingmen Traditional Chinese Medicine Hospital from April 2018 to July 2019 were selected as the research subjects.According to the random drawing method, the patients were divided into the observation group (160 cases, 320 eyes)and the control group (151 cases, 302 eyes).Two groups were treated with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel of conductance treatment, and the meibomian gland was mechanical dredged.The observation group was treated with Polyethylene Glycol Eye Drops 4 times/d, and the control group was treated with Polyethylene Glycol Eye Drops every other day.The patients′ self-conscious symptom score, Schirmer Ⅰtest (SⅠT), tear film rupture time(BUT), corneal fluorescein staining score and lipid trait score were compared between the two groups.Results There were no significant differences in BUT, corneal fluorescein staining and conscious symptom scores between the two groups before treatment (P>0.05).After treatment, BUT in the observation group was longer than that in the control group, and the corneal fluorescein staining and conscious symptom score in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment, lipid trait scores of the two groups were lower than those before treatment, and the difference was statistically significant (P＜0.05).There was no significant difference in SⅠT between the two groups before and after treatment (P>0.05).There were no obvious adverse reactions in the two groups during the process of the treatment.Conclusion The clinical effect of standard Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel for the treatment of eyelid gland dysfunction type xerophthalmopathy is better and has high safety. 2021 Vol. 28 (8): 115-118 [Abstract] ( 57 ) HTML (37 KB)  PDF  (0 KB)  ( 5 ) 119 Clinical application effect of minimally invasive tooth extraction and traditional tooth extraction in patients with mandibular impacted wisdom teeth extraction QIN Wen-long Objective To explore the clinical application effect of minimally invasive tooth extraction and traditional tooth extraction in patients with mandibular impacted wisdom teeth extraction.Methods A total of 124 patients with mandibular impacted wisdom teeth extraction who were admitted to Chengdu Women′s and Children′s Central Hospital from November 2018 to December 2019 were selected as the research subjects.They were divided into two groups according to the admission sequence by odd-even grouping method.The odd numbers were the reference group (62 cases,62 teeth) and the even numbers were the study group (62 cases, 62 teeth).Patients in the reference group were treated with traditional tooth extraction, and in the study group, minimally invasive tooth extraction was used.After tooth extraction, visual analogue scale (VAS) score, mouth opening restriction rating, tooth extraction duration, and the total incidence of intraoperative and postoperative complications were compared between the two groups.Results The VAS score of the study group after tooth extraction was lower than that of the reference group, and the difference was statistically significant (P＜0.05).The degree of mouth opening restriction of the study group was milder than that in the reference group, and the difference was statistically significant (P＜0.05).The total extraction time of the study group was shorter than that of the reference group, and the difference was statistically significant (P＜0.05).The total incidence of intraoperative complications in the study group was lower than that in the reference group, and the difference was statistically significant (P＜0.05).The total incidence of postoperative complications in the study group was lower than that in the reference group, and the difference was statistically significant (P＜0.05).Conclusion In the extraction of impacted mandibular wisdom teeth, minimally invasive tooth extraction obtains a more prominent clinical effect than traditional tooth extraction in regardless of significant reduction in the occurrenceboth intraoperative and postoperative complications. 2021 Vol. 28 (8): 119-121转125 [Abstract] ( 37 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 122 Combined effect of root canal surgery, periodontal and occlusal adjustment in treatment of retrograde pulpitis LI Kun Objective To investigate combined effect of root canal surgery, periodontal and occlusal adjustment in treatment of retrograde pulpitis.Methods A total of 112 patients with retrograde pulpitis who were admitted to Fushun Hospital of Chinese Medicine from April 15, 2018 to June 18, 2019 were selected as study subjects.They were divideded into study group and control group according to random number table method, with 56 cases in each group.The study group adopted the combined treatment of root canal therapy, periodontal therapy and occlusal adjustment, while the control group adopted root canal therapy.The levels of tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2),tooth mobility score, percussion pain score and the total incidence of adverse reactions were compared between the two groups.Results The levels of TNF-α and IL-2 in the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).The levels of TNF-α and IL-2 in the study group were lower than those in the control group after treatment, and the differences were statistically significant (P＜0.05).After treatment, the scores of tooth mobility score and percussion pain in both groups were lower than those before treatment,and the differences were statistically significant (P＜0.05).After treatment, the scores of tooth mobility score and percussion pain in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Comparison of the total incidence of adverse reactions between the two groups, the difference was not statistically significant (P＞0.05).Conclusion Application of combination of root canal surgery, periodontal and occlusal adjustment in treatment of patients with retrograde pulpitis can effectively reduce the degree of tooth loosening, relieve pain and improve the curative effect. 2021 Vol. 28 (8): 122-125 [Abstract] ( 50 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 126 Effect of different interventions on the diopter and eye axis of juvenile myopia patients DENG En-li Objective To explore the effect of different interventions on the diopter and eye axis of juvenile myopia patients.Methods The clinical data of 86 adolescent myopia patients treated in Dalian Maternal and Child Health Care Hospital from January 2017 to June 2019 were analyzed retrospectively.According to the difference of intervention method, they were divided into frame glasses group (30 cases, 52 eyes), orthokeratology group (29 cases, 53 eyes) and low-concentration atropine group (27 cases, 49 eyes).Frame glasses group routinely fitted single focus frame glasses after routine ophthalmology examination, the orthokeratology group selected an appropriate orthokeratology lens according to corneal eccentricity, corneal center curvature radius and corneal diopter, the low-concentration atropine group used 0.1 g/L Atropine eye drops before going to bed and wore frame glasses during the day.The changes of diopter, eye axis,naked eye vision, and tear film rupture time (BUT) were compared among the three groups.Results At 6 months after the intervention, the refractive power of the frame glasses group was lower than that before intervention, and the eye axis was longer than than that before intervention, the differences were statistically significant (P＜0.05).Compared refractive power and eye axis between orthokeratology group and low-concentration atropine group, the difference was not statistically significant (P＞0.05).At 6 months after intervention, the uncorrected visual acuity of the three groups was higher than that that before intervention, and the visual acuity of the orthokeratology group and the low-concentration atropine group was higher than that of the frame glasses group, the differences were statistically significant (P＜0.05).At 6 months after intervention, the BUT values in the orthokeratology lens group and the low-concentration atropine group were shorter than those before intervention, the differences were statistically significant (P＜0.05).Conclusion Compared with the frame glasses correction method, orthokeratology and low-concentration Atropine correction can more effectively control the diopter and eye axis growth of adolescents, which is conducive to controlling the development of adolescent myopia, but orthokeratology is not effective in stabilizing the tear film. 2021 Vol. 28 (8): 126-129 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 130 Evaluation on the effect of pulp regeneration treatment on infected young permanent teeth CHEN Ming；YU Peng Objective To explore the clinical effect endodontic pulp revascularization treatment for infected young permanent teeth.Methods A total of 96 young permanent tooth infection patients admitted to Fushun Stomatological Hospital from December 2018 to December 2019 were selected as the research objects.According to the random number table method, they were divided into observation group (48 cases) and control group (48 cases).The control group used routine Root apex formation, the observation group used root canal pulp vascular regeneration.The clinical efficacy,pain degree after treatment, and mental state score of the two groups were compared.Results The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The pain degree of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).After treatment, the self-rating anxiety scale (SAS) and self-rating depression scale(SDS) scores of patients in the two groups were lower than those before treatment, and the SAS and SDS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion The treatment of root canal pulp vascular regeneration for young permanent tooth infection patients can effectively reduce the pain of the patients, improve the treatment effect of the disease, and significantly improve the mentality of the patients, with high application value. 2021 Vol. 28 (8): 130-132 [Abstract] ( 54 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 133 Effect of tongue muscle functional training combined with psychological counseling on self-efficacy of children undergoing early treatment for malocclusion HE Jia Objective To explore effect of tongue muscle functional training combined with psychological counseling on self-efficacy of children undergoing early treatment for malocclusion.Methods A total of 136 cases with malocclusion who were admitted to the Department of Pediatric Dentistry, Dalian Stomatological Hospital from August 2018 to December 2019 were selected.They were divided into an observation group (68 cases) and a control group (68 cases) according to the random number table method.Both groups were given psychological counseling during early treatment,and the observation group was additionally given 8 weeks of tongue muscle functional training.Correction effects of the two groups were evaluated, and the anterior teeth coverage depth, upper incisor inclination, lower anterior teeth inclination, self-efficacy changes and nursing satisfaction were recorded before and after treatment.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P＜0.05).Before intervention, there were no statistically significant differences in anterior teeth coverage depth, upper incisor inclination and lower anterior teeth inclination between the two groups (P＞0.05).After intervention, the anterior tooth coverage and upper incisor inclination of both groups were smaller than those before intervention, while the lower anterior teeth inclination was larger than that before intervention, and the differences were statistically significant (P＜0.05).After intervention, the anterior tooth coverage and upper incisor inclination in the observation group was lower than that in the control group, and the lower anterior teeth inclination was higher than that in the control group, and the differences were statistically significant (P＜0.05).Before intervention, there was no significant difference in self-efficacy score between the two groups (P＜0.05).After intervention, the self-efficacy scores of the two groups were higher than those before intervention, and the difference was statistically significant (P＜0.05).After intervention, that self-efficacy score of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total satisfaction degree of nursing care in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Applying tongue muscle functional training in psychological nursing of patients undergoing early treatment for malocclusion can improve the anterior teeth coverage depth, upper incisor inclination and lower anterior teeth inclination as well as the patient′s self-efficacy.It can also promote the development of harmonious nurse-patient relationship. 2021 Vol. 28 (8): 133-136 [Abstract] ( 40 ) HTML (43 KB)  PDF  (0 KB)  ( 7 ) 137 Application of transepithelial excimer laser keratectomy in patients with low and moderate myopia ZHANG Rui；ZHANG Qiao-si；LIANG Wei；YU Chun-jing Objective To explore the clinical value of transepithelial excimer laser keratectomy in patients with low and moderate myopia.Methods A total of 80 patients (80 eyes) with low and moderate myopia admitted to The Third People′s Hospital of Dalian from May 2018 to May 2019 were selected as the research subjects.According to the random number table method, they were divided into observation group and control group, with 40 cases (40 eyes) in each group.Patients in the control group underwent personalized femtosecond laser assisted in-situ keratomi (F-LASIK) surgery, and in the observation group,patients accepted transepithelial photorefractive keratectomy(Trans-PRK).The corneal endothelial cell density before and after the operation, the corneal high-order aberration and the ocular high-order aberration at the pupil diameter of 3 mm after one year operation, and the vision before and after the operation were all compared between the two groups.After 1-year follow up visits, the occurrence of complications between the two groups was compared.Results The density of corneal endothelial cells in the observation group was greater than that of the control group at 1 year after surgery, the differences were statistically significant (P＜0.05).The corneal higher-order aberration of cornea at a pupil diameter of 3 mm in the observation group was lower than that of the control group, and ocular higher-order aberration was lower than that of the control group, the differences were statistically significant (P＜0.05).The visual acuity of the observation group was high than that of the control group at 1 year after operation, the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Compared with F-LASIK,Trans-PRK treatment for low and moderate myopia can better promote the growth of corneal cells and improve the vision of patients with fewer complications and higher safety. 2021 Vol. 28 (8): 137-139 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 140 Application of perioperative multidisciplinary pain management combined with psychological intervention in modified radical mastectomy SHU Hua；LIANG Zheng；HUANG Da-xue；LI Jing；WANG Dan Objective To investigate the application and clinical effect of perioperative multidisciplinary pain management combined with psychological intervention in modified radical mastectomy.Methods A total of 180 cases of breast cancer patients in the Second People′s Hospital of Neijiang from June 2017 to December 2018 were selected and divided into group A, group B and group C according to random number table method, 60 cases in each group.All patients were given general anesthesia through tracheal in tubation.Group A was given postoperative patient controlled intravenous analgesia (PCIA), group B was given nerve block combined postoperative PCIA, and group C was given psychological intervention combined nerve block and postoperative PCIA.The postoperative analgesia time was 48 h.Visual analogue score (VAS), PCIA pressing times and dosage of postoperative nonsteroidal analgesic of the three groups were observed at the first and third day after operation, Zung depression (SDS) and anxiety scale (SAS) were used to evaluate the psychological status of the three groups before operation and at the first and third day after operation, and the recent complications and hospital stay were observed among the three groups.Results There was no significant difference in preoperative VAS score among the three groups (P＞0.05).The VAS scores at the first and third days after operation in group C were lower than those in group A and group B, the differences were significant difference (P＜0.05).Pressing time of PCIA and dosage of postoperative nonsteroidal analgesic in C group were less than those in group A and group B, the differences were significant difference (P＜0.05).There were no significant differences in preoperative SDS and SDA scores among the three groups (P＞0.05).The SDS and SDA scores at the first and third days after operation in group C were lower than those in group A and group B, the differences were significant difference (P＜0.05).The total incidence of complications in group C was lower than that in group A and group B, the differences were significant difference (P＜0.05).The hospital stay in group B and group C was shorter than that in group A, the differences were significant difference (P＜0.05).Conclusion Perioperative multidisciplinary pain management combined with psychological intervention can alleviate psychological and physiological stress response in patients with modified radical mastectomy for breast cancer, relieve psychological pressure, improve analgesic effect after operation, and promote rehabilitation after operation. 2021 Vol. 28 (8): 140-143 [Abstract] ( 46 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 144 Application effect of Ropivacaine combined with Sufentanil for brachial plexus block in children undergoing upper limb surgery YANG Liu；WANG Zhu；YAO Shao-hong；ZHENG Rong Objective To explore the application effect of Ropivacaine combined with Sufentanil brachial plexus block in children with upper limb surgery.Methods A total of 60 children who underwent upper limb surgery in Central People′s Hospital of Zhanjiang from January 2019 to June 2020 were selected, they were divided into the control group and the observation group, 30 cases in each group.The control group was given Ropivacaine for brachial plexus block, the observation group was given Ropivacaine combined with Sufentanil for brachial plexus block.The pain scores (FLACC scores) at 1, 2, 4, 6, 8, 10, 12 h after operation, the anesthesia effect, the dosage of postoperative analgesics and the incidence of adverse reactions were compared between the two groups.Results There was no significant difference in FLACC score between the two groups at 1, 12 h after operation (P＞0.05).The FLACC scores of the two groups at 2, 4,6, 8, 10, 12 h after operation were higher than those at 1 h after operation (P＜0.05), and the FLACC scores of the observation group at 2, 4, 6, 8, 10 h after operation were lower than those of the control group (P＜0.05).The onset time of brachial plexus block of the observation group was earlier than that of the control group, the duration of continuous analgesia of the observation group was longer than that of control group (P＜0.05).The postoperative analgesic dosage of the observation group was less than that of the control group (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion In pediatric upper limb surgery anesthesia,the application of Ropivacaine combined with Sufentanil brachial plexus block has better effect, faster onset, longer analgesia time, and does not increase the incidence of adverse reactions in children. 2021 Vol. 28 (8): 144-146转150 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 147 Effect of Ketotifen combined with Salbutamol in the treatment of children with asthma SONG Yi Objective To explore the effect of Ketotifen combined with Salbutamol in the treatment of children with asthma.Methods A total of 72 children with asthma admitted in the Third Affiliated Hospital of CQMU from February 2019 to February 2020 were selected as the research objects, and they were divided into a control group (36 cases) and a test group (36 cases) according to the lottery method.The patients in control group were treated with Salbutamol, and the patients in test group were treated with Salbutamol and Ketotifen.The clinical total effectiveness, day and night symptom scores, serum endothelin-1 (ET-1) and circulating endothelial cell (CEC) levels were compared between the two groups.Results The clinical effective rate of test group was higher than that in control group, the difference was statistically significant (P＜0.05).Before treatment, the differences in clinical symptom scores between the two groups were not statistically significant (P＞0.05);after treatment, the clinical symptom scores of two groups were all lower than those before treatment, and the differences were statistically significant (P＜0.05);after treatment, the clinical symptom scores of the test group were lower than those in control group, the differences were statistically significant(P＜0.05).Before treatment, there were no statistically significant differences in the levels of ET-1 and CEC between the two groups(P＞0.05);after treatment, the levels of ET-1 and CEC in two groups were all lower than those before treatment, and the differences were statistically significant (P＜0.05);after treatment, the levels of ET-1 and CEC in test group were lower than those in control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the adverse reaction ratio between the two groups (P＞0.05).Conclusion Ketotifen combined with Salbutamol in the treatment of asthma is helpful to improve the effectiveness of the treatment, improve the clinical symptoms, and has high safety. 2021 Vol. 28 (8): 147-150 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 151 Clinical effect of Levocetirizine Hydrochloride Tablets combined with Compound Glycyrrhizin Tablets in the treatment of dermatitis and eczema HE Wen-qiang Objective To explore the clinical effect of Levocetirizine Hydrochloride Tablets combined with Compound Glycyrrhizin Tablets in the treatment of dermatitis and eczema.Methods A total of 126 patients with dermatitis and eczema were selected from October 2018 to November 2019 in Iron Coal General Hospital of Liaoning Health Industry Group.The patients were divided into control group (63 cases) and study group (63 cases) according to the random number table method, the control group accepted Levocetirizine Hydrochloride Tablets treatment, the study group accepted Levocetirizine Hydrochloride Tablet combined with Compound Glycyrrhizin Tablets, and the two groups were compared in terms of pruritus, erosion and total effective rate.Results Before treatment, there were no significant differences in the scores of pruritus and erosion between the two groups of patients (P＞0.05);after treatment, the scores of pruritus and erosion in the study group were lower than those of the control group, the differences were statistically significant (P＜0.05).The total effective rate of treatment in the study group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Levocetirizine Hydrochloride Tablets combined with Compound Glycyrrhizin Tablets are effective in the treatment of dermatitis and eczema, and improve the clinical symptoms,making up for the shortcomings of single drug. 2021 Vol. 28 (8): 151-153 [Abstract] ( 51 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 154 Discussion on the experience of TCM treatment of atherosclerosis QI Lei；LI Hua-gang；ZHOU Yu-zhu；ZHANG Yu Based on the theories of traditinal Chinese medicine (TCM) and the thoughts and achievements of modern medical research on atherosclerosis (AS), the author understands the three pathological stages of AS oriented by stages,namely formation stage of AS plaque treat with the principle of regulating the liver, nourishing the kidneys and strengthening the spleen: stable stages of AS plaque on the principle of clearing heat and detoxifying, rupture stages of AS plaque under the principle of activating blood circulation and removing blood stasis.The author suggests that the TCM treatment of AS should be based on the achievements of modern medical research and staged treatment according to the different stages of plaque formation and development, so as to improve the therapeutic effect. 2021 Vol. 28 (8): 154-156 [Abstract] ( 61 ) HTML (32 KB)  PDF  (0 KB)  ( 4 ) 157 Immediate effect observation of four needles for treating pharyngitis under the guidance of Quanxi Yixiang Theory in the treatment of acute pharyngitis and pharyngalgia LIU Jiao；ZHENG Wei-dong Objective To explore the immediate effect of four needles for treating pharyngitis under the guidance of Quanxi Yixiang Theory in the treatment of acute pharyngitis and pharyngalgia.Methods A total of 60 patients with acute pharyngitis and pharyngalgia who were treated in Jiangxi Pingxiang People′s Hospital from May 2019 to July 2020 were selected, and they were divided into an observation group and a control group according to the random number table, 30 cases in each group.The patients in control group were treated with ordinary acupuncture, and the patients in observation group were treated with four needles for treating pharyngitis guided by Quanxi Yixiang Theory.The pain improvement in different periods before and after acupuncture treatment and the satisfaction with the acupuncture effect were compared between the two groups.Results The visual analogue scale (VAS) scores of pain degree of the two groups were lower than those before treatment at 1-3 min, ＞3-10 min, ＞10-20 min, ＞20-30 min after acupuncture,and the differences were statistically significant (P＜0.05);at 1-3 min, ＞3-10 min, ＞10-20 min, ＞20-30 min after acupuncture, the VAS scores of the pain degree of observation group were all lower than those in control group, the differences were statistically significant (P＜0.05);the total satisfaction degree of acupuncture treatment in observation group was 90.00%, it was higher than that in the control group of 66.66%, and the difference was statistically significant(P＜0.05).Conclusion For patients with acute pharyngitis and pharyngalgia, the immediate effect of four needles for treating pharyngitis guided by Quanxi Yixiang Theory is better, it can further reduce pain and improve the satisfaction. 2021 Vol. 28 (8): 157-159 [Abstract] ( 47 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 160 Analysis of the effect and safety of Bushen Huoxue Decoction combined with Low Molecular Weight Heparin in the treatment of prethrombotic recurrent miscarriage in early pregnancy LIU Yu-xin；QI Bing Objective To analyze the effect and safety of Bushen Huoxue Decoction combined with Low Molecular Weight Heparin in the treatment of prethrombotic recurrent miscarriage in early pregnancy.Methods A total of 60 patients with recurrent miscarriage at prethrombotic state who visited the Gynecological Clinic of Beijing Tongrentang Hospital of Traditional Chinese Medicine from January 2017 to January 2019 were selected as the research subjects.They were randomly grouped according to the principle of voluntariness, and divided into control group (n=30) and experimental group (n=30).The two groups were treated with Low Molecular Weight Heparin under basic corpus luteum support.In the experimental group, Bushen Huoxue Decoction on the basis of the control group was added.After 42 days of treatment, the uterine artery blood flow parameters, blood coagulation function index, traditional Chinese medicine(TCM) syndrome integral, total effectiveness rate of treatment and total adverse reaction rate were compared between the two groups.Results After treatment, the left resistance index (RI) was (0.771±0.056), right RI was (0.784±0.047),uterine artery maximum blood flow velocity/end diastolic blood flow velocity (S/D) was (10.66±1.35), fibrinogen was(2.22±0.16) g/L, and D-dimer was (161.53±45.38) μg/mL, all lower than those of the control group of (0.817±0.076),(0.844±0.053), (11.73±1.39), (3.48±0.27) g/L and D-dimer (262.70±43.51) μg/mL, with statistical significances (P＜0.05).The integral of TCM syndromes of the experimental group was (7.83±2.33) points, which was lower than that of the control group of (11.89±1.88) points, with statistical significance (P＜0.05).The total effectiveness rate of treatment in the experimental group was 93.34%, which was higher than that in the control group accounting for 76.66% with statistical significance (P＜0.05).The total adverse reaction rate in the experimental group was 6.67%, which was lower than that in the control group accounting for 16.67%, and the difference was statistically significant (P ＜0.05).Conclusion Compared with Western medicine treatment, Bushen Huoxue Decoction combined with Low Molecular Weight Heparin has a significant effect on the treatment of prethrombotic recurrent miscarriage, which is more beneficial to improve the various indicators of the patient′s body, so that the total effectiveness rate of treatment is greatly improved, and it is safe and feasible. 2021 Vol. 28 (8): 160-164 [Abstract] ( 35 ) HTML (42 KB)  PDF  (0 KB)  ( 8 ) 165 Clinical efficacy study on bioinformatics infrared liver disease therapeutic instrument Qimen acupoint irradiation combined with Biejiajian Pills in the treatment of compensated liver cirrhosis CHEN Ling；ZOU Bi-ying；YIN Dong-lin Objective To investigate the clinical effect on bioinformatics infrared liver disease therapeutic instrument(BILT treatment instrument) Qimen acupoint irradiation combined with Biejiajian Pills in the treatment of compensated liver cirrhosis.Methods A total of 60 patients with compensatory cirrhosis treated in the Hepatology Department of Jiujiang Traditional Chinese Medicine Hospital from July 2019 to February 2020 were selected as the research objects,and they were divided into the observation group and the control group according to random number table method, with 30 cases in each group.The observation group was treated with BILT liver disease treatment instrument Qimen acupoint irradiation+Biejiajian Pills, and the control group was treated with Biejiajian Pills orally.The changes in the four fiber items and liver stiffness were compared between the two groups.Results After 2, 4, and 6 weeks of treatment, the levels of laminin (LN), hyaluronidase (HA), type Ⅳcollagen (Ⅳ-C), type Ⅲprocollagen (PC Ⅲ) and liver stiffness in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion BILT liver disease treatment Qimen acupoint irradiation combined with Biejiajian Pills has a definite effect in the treatment of compensatory liver cirrhosis, which can reduce liver damage, reduce the degree of liver fibrosis, and reduce liver stiffness, and has high clinical promotion value. 2021 Vol. 28 (8): 165-167转174 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 168 Effect of Tiotropium Bromide combined with Bufei Huoxue Capsules on quality of life and respiratory function in patients with pneumoconiosis LI Zhi-teng；GONG Xiang-wen；LIU Chun-yun Objective To investigate the effect of Tiotropium Bromide combined with Bufei Huoxue Capsules on quality of life and respiratory function in patients with pneumoconiosis.Methods A total of 80 patients with pneumoconiosis admitted to Ganzhou Fifth People′s Hospital from January 2019 to March 2020 were selected as the research objects and divided into the observation group and the control group according to random number table method, with 40 patients in each group.The observation group was treated with Tiotropium Bromide combined with Bufei Huoxue Capsules, and the control group was treated with Tiotropium Bromide.Both groups were treated for 12 weeks.Quality of life(6-minute walk test [6MWT]distance, Brog dyspnea score, St.George′s respiratory questionnaire [SGRQ]score) and respiratory function (forced expiratory volume in first second [FEV1], diffusion capacity for carbon monoxide [DLCO])were compared between the two groups before and after treatment.Results After treatment, the distance of 6MWT in both groups was longer than that before treatment, Brog and SGRQ scores were lower than those before treatment, and the distance of 6MWT in the observation group was longer than that in the control group, and the Brog and SGRQ scores in the observation group were lower than those in the control group, the differences were significant statistically(P＜0.05).After treatment, FEV1 and DLCO levels in the two groups were higher than those before treatment, and FEV1 and DLCO levels in the observation group were higher than those in the control group, the differences were significant statistically (P＜0.05).Conclusion For patients with pneumoconiosis, Tiotropium Bromide combined with Bufei Huoxue Capsules can improve their life quality and respiratory function. 2021 Vol. 28 (8): 168-170 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 171 Value of serum glycolic acid in the diagnosis of liver diseases LIU Xiao-mei；GAN Fu-sheng Objective To explore the value of serum glycocholic acid (CG) in the diagnosis of liver diseases.Methods A total of 200 patients with liver disease admitted to the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2018 to December 2019 were selected as the observation group, further according to liver disease, they were divided into liver cancer group, viral hepatitis group and cirrhosis group, and 200 healthy subjects who received physical examination during the same period were selected as the control group, serum CG and other liver function indexes were detected.Liver function indexes were compared, and the correlation between serum CG level and other liver function indexes in patients with different liver diseases was analyzed, as well as the diagnostic efficacy of liver function indexes for various liver diseases.Results Serum levels of CG, total bile acid (TBA), glutamic-oxalacetic transaminase (ALT), alanine aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (TBil) in liver cancer group were higher than those in control group, viral hepatitis group and cirrhosis group, the differences were statistically significant (P＜0.05).The indexes of cirrhosis group were higher than those of viral hepatitis group and control group, the differences were statistically significant (P＜0.05).The indexes of viral hepatitis group were higher than those of the control group, the differences were statistically significant (P＜0.05).In viral hepatitis group, cirrhosis group and liver cancer group, there was a positive correlation between serum CG and TBA, ALT, AST, ALP, TBil (P＜0.05).The diagnostic efficacy of serum CG in viral hepatitis, liver cirrhosis and liver cancer was higher than that of other liver function indexes, and the differences were statistically significant (P＜0.05).Conclusion Serum CG is usually abnormally elevated in liver lesions.Serum CG has a good value in differential diagnosis of liver lesions 2021 Vol. 28 (8): 171-174 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 175 Application value of urine sediment microscopic examination and urine routine dry chemical method in urine routine examination LIN Hua Objective To explore the value of urinary sediment microscopic examination and urine routine dry chemical method in routine urine examination.Methods A total of 340 urine samples admitted to Shenyang Fifth People′s Hospital from January 2018 to January 2020 were selected as the research subjects, microscopic examination of urinary sediment, routine dry chemistry and the combination of the two methods were performed.The positive rates of white blood cell, urine protein and red blood cell of the three detection methods were compared.Results There were no significant differences in the sensitivity, specificity and accuracy between microscopic examination of urinary sediment and routine dry chemical method (P＞0.05).The sensitivity, specificity and accuracy of the combined detection of the two methods were higher than those of the single method, and the differences were statistically significant (P＜0.05).The positive rate of quantitative leukocyte in urine dry chemistry test was lower than that in urine sediment microscopic examination, and the positive rate of quantitative erythrocyte in urine sediment microscopic examination was higher than that in urine sediment microscopic examination, and the differences were statistically significant (P＜0.05).Quantitative leukocyte positive rate and quantitative erythrocyte positive rate of combined detection were higher than those of urine routine dry chemical method and urinary sediment microscopic examination, the differences were statistically significant(P＜0.05).Conclusion Both urine sediment test and routine dry chemical urine test have clinical testing value, and the combined application of the two detection methods is more effective in reducing the probability of missed diagnosis and misdiagnosis, and improving the level of clinical testing. 2021 Vol. 28 (8): 175-177 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 178 Analysis of 7383 infertile women infected with TORCH in a hospital from 2017 to 2019 WEN Gui-Ping；GE Yun-Sheng；ZHOU Yu-lin▲ Objective To investigate the prevalence of TORCH infection in infertile women.Methods Serum samples of 7383 infertile women from January 2017 to December 2019 were collected in the Women and Children′s Hospital Affiliated to Xiamen University, and the TORCH-IgM antibody was detected by chemiluminescence method.Results The positive rate of TORCH-IgM in infertile women was 12.66%.The positive rates of herpes simplex virus IgM,rubella virus IgM, cytomegalovirus IgM and Toxoplasma gondii IgM were 10.89%, 1.22%, 0.39% and 0.16%, respectively.The positive rate of herpes simplex virus IgM was higher than that of rubella virus, cytomegalovirus and Toxoplasma gondii, and the positive rate of herpes simplex virus IgM in 2019 was higher than that of 2017 and 2018, the differences were statistically significant (P＜0.05).The positive rate of TORCH-IgM in different seasons was statistically significant (P＜0.05).There was no significant difference in the positive rate of TORCH-IgM among different age groups(P＞0.05).Conclusion There is a certain percentage of TORCH infection among infertile women.It is necessary to strengthen the screening and monitoring of TORCH infection in such population, so as to achieve prevention and early intervention and improve the quality of newborn population. 2021 Vol. 28 (8): 178-181 [Abstract] ( 34 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 182 Application of mobile phone WeChat in the observation of results of outpatients after PPD trial LI Li-ying；HUANG Yan-qun；LEI Shu-qin Objective To explore the application of mobile phone WeChat in the observation of results of tuberculin test (PPD) in outpatients.Methods A total of 800 patients undergoing the PPD test admitted to Jiangxi Thoracic Hospital from July to December 2019 were selected as the research objects, and they were divided into the control group(400 cases) and the observation group (400 cases) according to the method of dynamic randomization.The control group was given the conventional method to receive the observation results, and the observation group was given the mobile phone WeChat to receive the observation results.The compliance, satisfaction and mental state of the two groups were compared.Results The total compliance of the observation group after intervention was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total satisfaction of the observation group after intervention was higher than that of the control group, and the difference was statistically significant (P＜0.05).The anxiety,fear, tension, insomnia and memory or attention deficit score after intervention in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion The application effect of mobile phone WeChat in the observation results of outpatients after PPD test is significant, it can not only improve the compliance of patients with receiving results, but also improve the satisfaction level of outpatient services, greatly improve the psychology and emotions of patients, and which have higher application value and promotion value. 2021 Vol. 28 (8): 182-184 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 5 ) 185 Application effect of PDCA cycle management in sterilization quality monitoring and management of disinfection and supply center WANG Li；JIANG Jie Objective To explore the application effect of PDCA cycle management in sterilization quality monitoring and management of disinfection supply center.Methods A total of 100 disinfection articles in Shanxi Provincial General Hospital of Armed Police Force from January to December 2018 were randomly selected as the control group, and 100 disinfection articles in Shanxi Provincial General Hospital of Armed Police Force from January to December 2019 were randomly selected as the experimental group.The control group was given routine management method, and the experimental group was given PDCA cycle management method.The qualified rate of sterilization effect, satisfaction degree of clinical department disinfection and sterilization articles and staff assessment results of the two groups were compared.Results The qualified rate of biological monitoring sterilization effect, B-D test sterilization effect qualification rate and chemical monitoring sterilization effect qualification rate of the experimental group were higher than those of the control group, the differences were statistically significant (P＜0.05).The total satisfaction of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05).The result of staff assessment in the experimental group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Adding the PDCA cycle management method to the disinfection supply center can increase the qualification rate of the sterilization effect, the overall satisfaction of the disinfection and sterilization items in the clinical department, and can promote the improvement of the staff′s assessment performance, which has important application value. 2021 Vol. 28 (8): 185-187 [Abstract] ( 61 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 188 Application effect of multidisciplinary team nursing model in patients with pregnancy complicated with tuberculosis LIAO Qian；WU Chuan-fang；QU Qun-fang；XIE Xiao-hui；LI Yan-rong Objective To explore the effect of multidisciplinary team (MDT) nursing model in patients with pregnancy complicated with tuberculosis.Methods A total of 69 cases of pregnant patients with tuberculosis admitted to the Tuberculosis Diagnosis and Treatment Center of a hospital in Hu′nan from January 2015 to December 2017 were selected as research objects and divided into two groups according to the historical control study.There were 34 cases in the control group for routine nursing;and in the observation group, 35 cases carried out the MDT nursing model.The treatment compliance, complication rate, patient satisfaction, hospital stay and pregnancy outcome before and after intervention were compared between the two groups.Results The treatment compliance of the observation group was higher than that of the control group, the incidence of complications was lower than that of the control group, the pregnancy outcome was better than that of the control group, the patient satisfaction in the observation group was higher than that in the control group, and the hospitalization time was shorter than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion The MDT nursing model for pregnant patients with tuberculosis can improve the treatment effect, pregnancy outcome and nursing quality. 2021 Vol. 28 (8): 188-192 [Abstract] ( 42 ) HTML (41 KB)  PDF  (0 KB)  ( 6 ) 193 A case of neonatal pleural effusion due to central venous catheter inserted through lower limb veins CHEN Li-lian；XIONG Xiao-yun；WEN Chun-ying；YANG Chuan-zhong Peripherally inserted central catheter (PICC) is a common vein access in critically ill newborns, especially in very low birth weight infants or extremely low birth weight infants.Pleural effusion is one of the complications related to PICC, which can be life-threatening in severe cases.It has been reported from time to time that PICC was placed through the upper extremity veins and complicated with pleural effusion, but the cases of pleural effusion complicated by the catheterization through the lower extremity veins is rare.This paper presented a case of newborn with 32+6 weeks, who was infused with intravenous nutrient solution (TPN) by PICC through the great saphenous vein of lower extremity on the 3rd day after birth.On the 9th day after birth, the baby developed symptoms such as shortness of breath and rapid heart rate.Chest radiography and B-ultrasound showed pleural effusion, which disappeared two days after the catheter was removed.Based on the results of chest radiographs of the child and related literature, it was considered that the cause of this case was pleural effusion caused by the misinsertion of PICC catheter into the azygian vein. 2021 Vol. 28 (8): 193-196 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 197 A case of multiple myeloma starting with thoracic spine mass YI Wen-jing；WANG Yi；LIU Song-shan；DENG Jie The paper reported a case of multiple myeloma (MM) admitted to Affiliated Hospital of Chengdu University of Traditional Chinese Medicine with thoracic mass as the first case.Combined with relevant literature review, the clinical manifestations, disease characteristics, prognosis and treatment options of MM and extramedullary plasmacytoma (EMP) were differentiated, so as to reduce clinical misdiagnosis and mistreatment.A 57 years old male patient presented to the orthopedics department due to repeated weakness of both lower limbs at the first episode.The abnormal signal of the 6th thoracic vertebrae and appendages was found by MRI.The nature of the lesion did not exclude tumor lesions, and pathology after lumpectomy was performed.The biopsy showed diffuse infiltration of plasma cell-like cells, and immunohistochemistry mainly expressed plasma cell markers, considering plasma cell tumors;further improvement of serum protein electrophoresis revealed an abnormal increase in M protein,and serum immunofixation electrophoresis showed IgG LAM type M protein (+), bone marrow biopsy revealed a small number of CD138(+), Igκ(+) or Igλ (+) plasma cells scattered and distributed.For the diagnosis of malignant plasmacytoma, EMP is more likely to be considered.Long-term regular oral administration of lenalidomide and dexamethasone outside the hospital.The disease has progressed in the past two years after the control of the disease, and the bone marrow smear and flow cytometry have confirmed the abnormal increase of clonal plasma cells. 2021 Vol. 28 (8): 197-199 [Abstract] ( 45 ) HTML (29 KB)  PDF  (0 KB)  ( 5 ) 200 A case report and literature review of MRI manifestations of Pierre Robin sequence sign GAO Ya-li；PENG Song；YANG Qiao-li Pierre Robin sequence(PRS)is a congenital malformation with complex etiology and unclear pathogenesi.It is characterized by micrognathia, cleft palate, glossoptosis and airway stenosis, which can lead to difficulty in breathing and feeding after birth.The mortality of this disease is high, which seriously threatens the life safety of newborn.In this study, the infant was born prematurely at about 30 weeks of gestation and had dyspnea immediately after birth, and died after the rescue failed.In order to improve the understanding of the disease and improve the postpartum survival rate of children, we retrospectively analyzed and discussed the pathogenesis, etiology, clinical diagnosis, treatment and related literature review of fetal magnetic resonance imaging of PRS. 2021 Vol. 28 (8): 200-202 [Abstract] ( 53 ) HTML (26 KB)  PDF  (0 KB)  ( 6 ) 203 Application of modified Y-type disposable venous blood sampling needle in clinical blood sampling CHEN Xue-qin；TANG Wen；PAN Yan-juan Objective To explore the application effect of modified Y-type disposable venous blood collection needle in clinical blood collection.Methods A total of 200 patients admitted to Jiujiang First People′s Hospital Jiangxi Province from November 2019 to June 2020 were selected as the research objects, and they were divided into two groups according to the lottery method, 100 cases in each group.The control group used a disposable venous blood collection needle to collect blood, and the observation group used a modified Y-type disposable venous blood collection needle to collect blood.The success rate, blood contamination rate, blood sample qualification rate and satisfaction degree of the two groups were compared.Results The success rates of one-time blood collection from the dorsal hand vein, the median cubital vein, and the vein in the observation group were (98.00%, 99.00%, 96.00%), which were higher than those of the control group of (91.00%, 92.00%, 88.00%), and the differences were statistically significant (P＜0.05);the blood contamination rate of the observation group was 2.00%, lower than that of the control group for 9.00%, and the qualified rate of blood samples was 98.00%, higher than that of the control group 91.00%, the differences were statistically significant (P＜0.05).The total satisfaction rate of blood sampling was 98.00%, higher than that of the control group for 90.00%, the difference was statistically significant (P＜0.05).Conclusion The use of modified Y-type disposable venous blood sampling needle for blood sampling can reduce the blood contamination rate, improve the success rate of blood sampling, the qualified rate of blood samples and blood sampling satisfaction. 2021 Vol. 28 (8): 203-205 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 206 Design and clinical application of the drying rack for neonatal silicone mask HUANG；Lan LAI；Lian-mei；HU Zhu Objective To investigate the design and clinical application of wall-mounted silicone mask drying frame in neonates.Methods A total of 178 face masks from operating room of Ganzhou Maternal and Child Health Hospital,Jiangxi Province from November 2019 to January 2020 were selected.They were divided into the experimental group and the control group by random digital table method, 89 in each group.After cleaning, the control group was placed directly on the cleaning table to dry.20 nursing staff and 178 newborns were selected, and the satisfaction of nursing staff before and after using the wall-mounted silicone mask before and after drying was obtained.The condition，the secondary infection of mask and the incidence of respiratory tract infection were observed.Results The drying time of the mask in the experimental group was shorter than that in the control group, the secondary infection rate and the incidence of respiratory tract infection in newborns were lower than those in the control group, the differences were statistically significant (P＜0.05).The total satisfaction of nursing staff after using wall-mounted silicone mask was higher than that before, the difference was statistically significant (P＜0.05).Conclusion The design and clinical application of wall-mounted silicone mask drying frame have good clinical effect, it can not only shorten the drying time of the mask,reduce the secondary infection rate of the mask and the incidence of respiratory tract infection in the newborn, at the same time, it can also improve the satisfaction of the nursing staff, and has high clinical value. 2021 Vol. 28 (8): 206-208 [Abstract] ( 41 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 209 Application study of optimized MDT model in treatment of hyperthyroidism with iodine 131 HE Li-juan；HE Zhao；DENG Na；CHEN Si-ping；GONG Yu-ping Objective To explore the application of optimized multidisciplinary diagnosis and treatment (MDT) model in the treatment of hyperthyroidism with iodine 131.Methods One hundred patients with hyperthyroidism treated with iodine 131 who were admitted to Pingxiang People′s Hospital, Jiangxi Province from July 2019 to January 2020 were selected and divided into the control group (50 cases) and the observation group (50 cases) by the random number table method.The control group was given the conventional management model, while the observation group was given the optimized MDT model.The hospitalization time, treatment cost, return visit rate and patient satisfaction were compared between the two groups.Results After intervention, the hospitalization time of the observation group was shorter than that of the control group, and the treatment cost was lower than that of the control group, with statistical differences (P＜0.05).The total satisfaction and return visit rate of the observation group were higher than those of the control group,with statistical differences (P ＜0.05).Conclusion The application of optimized MDT model in patients with hyperthyroidism undergoing iodine 131 therapy significantly shortens the length of hospitalization time, reduces treatment cost, and improves patient satisfaction and return visit rate, indicating good application effect. 2021 Vol. 28 (8): 209-211 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 212 Effect of PDCA cycle management on postoperative physiological function recovery and lactation of parturients after cesarean section CHEN Xiao-yan Objective To investigate the effect of plan-do-check action (PDCA) cycle management on postoperative physiological function recovery and lactation of parturients after cesarean section.Methods A total of 100 women underwent cesarean section in Jiangxi Maternal and Child Health Hospital from July 2018 to January 2020 were selected as the research subjects.They were divided into the control group (n=50) and the observation group (n=50) by random number table method.Patients in the control group were given routine nursing intervention, and in the observation group, PDCA cycle management was combined.The lactation volume and physiological function recovery between the two groups were compared.Results There was no significant difference in generic quality of life inventory 74 (GQOLI-74) scale score between the two groups before nursing (P＞0.05).The observation group had higher physical function scores on the GQOLI-74 scale after 14 days of nursing than that of the control group, and the difference was statistically significant significance （P＜0.05）.The lactation volume at 72 h after delivery in the two groups was higher than that at 24 and 48 h after delivery, and the lactation value at 48 h after delivery was higher than that at 24 h, and the differences were statistically significant (P＜0.05).The lactation volume at 24, 48, 72 h after delivery in the observation group was higher than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion PDCA cycle management can promote postoperative physiological function recovery of parturients after cesarean section and increase postoperative lactation volume with satisfactory clinical application effect. 2021 Vol. 28 (8): 212-214 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 215 Application effect of predictive nursing in patients undergoing laparoscopic radical resection of colorectal cancer HE Ling；CHEN Xiao-na；DU Juan；YU Wei-jun Objective To explore the application effect of predictive nursing in patients undergoing laparoscopic radical resection of colorectal cancer.Methods A total of 92 patients undergoing laparoscopic surgery for colorectal cancer in Yingkou Central Hospital, Liaoning Province from January 2018 to December 2019 were selected and divided into two groups according to random number table method, 46 cases in each group.Patients in the control group were provided with routine perioperative nursing intervention, and in the observation group, predictive nursing was used until discharge.The operation status and the incidence of complications in the two groups were compared.Results The amount of bleeding in the observation group was (71.64±9.77) mL, less than that in the control group of (76.79±10.02) mL, the operation time, first getting out of bed, bowel movement, and first exhaust time were (138.25±13.91) min, (25.13±3.78) h,(26.04±4.15) h, and (34.36±5.52) h, shorter than those in the control group of (145.54±14.15) min, (29.50±5.19) h,(30.22±5.37) h, and (39.11±6.08) h, with statistical differences (P＜0.05).The total incidence of postoperative complications in the observation group was 4.35%, lower than that in the control group accounting for 17.39%, with statistical difference (P＜0.05).Conclusion The use of predictive nursing in patients undergoing laparoscopic radical resection of colorectal cancer can reduce surgical bleeding, shorten the operation time, time to get out of bed, and gastrointestinal recovery time, and decrease the incidence of complications. 2021 Vol. 28 (8): 215-217 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 218 Effect of predictive comprehensive nursing mode on fall and fall of stroke patients ZENG Xiao-yan Objective To explore the effect of predictive comprehensive nursing mode on the fall and fall of stroke patients.Methods A total of 60 stroke patients in Fuzhou First People′s Hospital, Jiangxi Province from September 2018 to April 2020 were selected as the research objects and divided into the observation group (30 cases) and the control group (30 cases) by random sample.The observation group was given predictive comprehensive nursing mode, and the control group was given routine nursing mode.The total incidence of falls, bed fall and complaints, nursing total satisfaction were compared between the two groups.Results After nursing, the total incidence of falls, bed falling and complaints in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).The total nursing satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion The implementation of predictive comprehensive nursing model for stroke patients can effectively reduce the occurrence of falls and falling off bed events, and further improve the comfort and satisfaction of patients. 2021 Vol. 28 (8): 218-220 [Abstract] ( 43 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 221 Application effect of comprehensive nursing in the treatment of pressure ulcer patients with Kangfuxin Solution and infrared ray FAN Yan-ling；LIAO Li；CHEN Yu-lan；CHEN Li Objective To explore the application effect of comprehensive nursing in the treatment of pressure ulcer patients with Kangfuxin Solution and infrared ray.Methods From June 2016 to March 2018, 60 patients with pressure sore treated in Yichun Hospital of Traditional Chinese Medicine, Jiangxi Province were selected as the research objects.All patients were treated with Kangfuxin Solution and infrared ray.On this basis, nursing work was carried out.According to the method of random comprehensive balance, they were divided into group A (30 cases) and group B (30 cases).Group A adopted routine nursing method and group B adopted comprehensive nursing method.The compliance, selfrating anxiety scale (SAS) and self-rating depression scale (SDS) scores and nursing satisfaction of the two groups were compared.Results The nursing total compliance of group B was higher than that of group A, and the difference was statistically significant (P＜0.05).Before the intervention, the SAS and SDS scores of the two groups had no significant difference (P＞0.05);after the intervention, the SAS and SDS scores of group B were lower than those of group A, the scores of SAS and SDS of two groups after intervention were lower than those before intervention, the differences were statistically significant (P＜0.05) The total nursing satisfaction of group B was higher than that of group A, the difference was statistically significant (P＜0.05).Conclusion The implementation of comprehensive nursing method in the process of Kangfuxin Solution combined with infrared ray in the treatment of pressure ulcer can effectively improve the nursing compliance of patients and improve their bad emotions.Patients and their families are satisfied with the nursing work. 2021 Vol. 28 (8): 221-223转227 [Abstract] ( 56 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 224 Effect of knowledge，attitude and practice nursing mode on mental state and postoperative rehabilitation of patients with hysteromyoma undergoing total abdominal hysterectomy ZHAN Xiao-fang；SHENG Li-qin Objective To explore the effect of knowledge attitude practice nursing mode in patients with hysteromyoma undergoing abdominal hysterectomy.Methods A total of 82 patients with uterine fibroids in Fuzhou Maternal and Child Health Center, Jiangxi Province from March 2018 to March 2020 were selected and divided into two groups according to random number table method, 41 cases in each group.The control group was given routine nursing, and the observation group was given knowledge, attitude and practice nursing mode on the basis of the routine nursing.After 2 months of intervention, the awareness of health knowledge was compared between the two groups;before and after 2 months of intervention, the psychological status of the two groups was compared;the postoperative recovery and prognosis of the two groups were compared.Results The awareness of health knowledge in the observation group was 97.56%, higher than 80.49% of the control group;the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The anal exhaust time, ambulation time and hospitalization time of the observation group were (29.06±7.75) h, (1.93±0.47) d, (12.20±4.29) d, which were shorter than (34.02±8.78) h, (2.78±1.14) d, (14.29±4.33) d in the control group;the total incidence of poor prognosis in the observation group was 4.88%, which was lower than 21.59% in the control group, the differences were statistically significant (P＜0.05).Conclusion The knowledge, attitude and practice nursing model can improve the awareness of health knowledge of patients with uterine fibroids undergoing abdominal hysterectomy, which is conducive to improve the psychological status of patients, accelerate the recovery after operation,reduce the incidence of complications and improve the prognosis. 2021 Vol. 28 (8): 224-227 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 228 Effect of psychological nursing combined with early sucking of newborn on postpartum hemorrhage HUYan Objective To explore the effect of psychological nursing combined with early newborn suckling on postpartum hemorrhage of primipara during vaginal delivery.Methods A total of 400 parturients admitted to Xinyu Maternity and Child Health Hospital, Jiangxi Province from January 2018 to December 2019 were selected.They were divided into the experimental group and the control group by two-color ball throwing, 200 cases in each group.In the control group, routine nursing midwifery and postpartum nursing were used.On the basis of the control group, parturients in the experimental group were given psychological nursing and early suckling of the newborn.The outcomes of the two groups were compared.Results The labor time, placenta delivery time and lactation initiation time in the experimental group were shorter than those in the control group, with statistical differences (P＜0.05).The bleeding volume 2 hours after delivery in the experimental group was less than that of the control group, the postpartum lactation volume was more than that of the control group, with statistical differences (P＜0.05).There was no difference in the negative emotion scores of the two groups before intervention (P＞0.05).The negative emotion scores of the two groups after intervention were lower than those before intervention, the negative emotion scores of the experimental group after intervention were lower than those of the control group, with statistical differences (P＜0.05).The postpartum hemorrhage rate, postpartum depression rate, and postpartum anxiety rate of the experimental group were lower than those in the control group, with statistical differences (P＜0.05).Conclusion The basic nursing intervention for parturients from vaginal delivery combined with psychological nursing and early neonatal sucking can promote uterine contractions, improve the negative emotions of the parturients, and reduce the rate of postpartum hemorrhage and postpartum depression. 2021 Vol. 28 (8): 228-231 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 5 ) 232 Application effect of diversity nursing in elderly patients with diabetes mellitus complicated with coronary heart disease HONG Wei-yan Objective To explore the application effect of diversified nursing in elderly patients with diabetes and coronary heart disease.Methods A total of 80 elderly patients with diabetes and coronary heart disease in Tieling Center Hospital, Liaoning Province from January to October 2019 were selected, and divide into the observation group and the control group according to random number table method, 40 cases in each group.Both groups were treated with Atorvastatin Tablets, and both groups were treated for 2 months.The control group was given routine nursing intervention,and the observation group was given diversified nursing intervention.The intervention period was 2 months.Two groups of patients′ psychological symptom scores before and after the intervention, health survey questionnaire (SF-36)score, after the intervention to the service satisfaction evaluation, cognition of the disease knowledge score, daily health behavior cognition score, improve the level of blood glucose control at the time, and cardiac function level 2 time,length of hospital stay and the incidence of hypoglycemia, heart failure were compared.Results There was no significant difference in the score of psychological symptoms between the two groups before intervention (P＞0.05).The scores of psychological symptoms in the two groups after intervention were lower than those before intervention, after intervention, the scores of psychological symptoms in the observation group were lower than those in the control group, the differences were statistically significant (P ＜0.05).There was no significant difference in SF-36 score between the two groups before intervention (P＞0.05).The SF-36 scores of the two groups after intervention were higher than those before intervention, the SF-36 score of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05).After intergroup intervention, the five-item scores of nurses in the observation group were higher than those in the control group, including problem solving ability, service attitude, operational skills, health education level of nurses, and frequency of nurses′ visits, after intergroup intervention, the cognitive scores of disease knowledge and daily health care behaviors in the observation group were higher than those in the control group, the time of blood glucose reaching the standard, the time of cardiac function improvement reaching level 2,and the length of hospital stay were shorter than those of the control group, the differences were statistically significant(P＜0.05).The total incidence of patients in the observation group was 5.00%, which was lower than 22.50% of the control group, the difference was statistically significant (P＜0.05).Conclusion Diversified nursing for elderly patients with diabetes and coronary heart disease can better promote patient recovery and increase satisfaction. 2021 Vol. 28 (8): 232-236 [Abstract] ( 48 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 237 Application of the knowledge-attitude-practice nursing model intervention in the early hemodialysis patients with chronic renal failure WU Xiao-qiong Objective To explore the application effect of the knowledge-attitude-practice nursing model in the early hemodialysis (HD) patients with chronic renal failure (CRF).Methods A total of 78 patients with HD the early stage of CRF treated in Huizhou Central People′s Hospital from May 2018 to April 2019 were selected and divided into the control group (n=38) and the observation group (n=40) by random number table method.The control group adopted routine nursing plan, and the observation group adopted the knowledge-attitude-practice nursing model.The psychological state, self-care ability and quality of life of the two groups were compared before and after 3 months of intervention.Results Before the intervention, there were no significant differences in self-rating anciety scale (SAS) and self-rating depression scale (SDS) scores between the two groups (P＞0.05);after the intervention, the SAS and SDS scores of the two groups were lower than those before the intervention, and the SAS and SDS scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).Before the intervention,there were no significant differences in the scores of self-care ability and quality of life between the two groups (P＞0.05).After the intervention, the scores of self-care ability and quality of life in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).Conclusion The knowledge-attitudepractice nursing model can effectively reduce the negative emotions of patients with CRF in early HD, improve the patients′ disease self-care ability and quality of life, which is worthy of application in clinical nursing. 2021 Vol. 28 (8): 237-240 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )

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