|
|
|
| Effect of Pregabalin combined with Mecobalamin on neuropathic pain and adverse reactions in patients with herpes zoster |
| GAO Jun-ming ZHAO Min WANG Dong-mei ZUO Xu WANG Qi |
| Department of Dermatology, Liaoyou Baoshihua Hospital of Panjin City, Liaoning Province, Panjin 124010, China |
|
|
|
|
Abstract Objective To investigate the effect of Pregabalin combined with Mecobalamin on neuropathic pain and adverse reactions in patients with herpes zoster, and to provide a basis for the clinical application of this therapy.Methods The clinical data of 82 patients with herpes zoster admitted to Liaoyou Baoshihua Hospital in Panjin from February 2019 to June 2020 were retrospectively analyzed.According to different treatment methods, they were divided into the observation group and the control group, with 41 cases in each group.The control group was treated with Mecobalamine, and the observation group was treated with Mecobalamine combined with Pregabalin.Neuropathic pain (visual analogue scale [VAS]score), inflammatory markers (interleukin [IL]-6, IL-8, C-reactive protein [CRP]) levels before and 2 weeks after treatment, and adverse reactions (sleepiness, fatigue, dizziness, nausea) during treatment were compared between the two groups.Results There was no significant difference in VAS score between the two groups before treatment (P＞0.05).The VAS scores in the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the VAS score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences in the levels of IL-6, IL-8 and CRP between the two groups (P＞0.05).After treatment, the levels of IL-6, IL-8 and CRP in the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the levels of IL-6, IL-8 and CRP in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Pregabalin combined with Mecobalamin has a significant effect on the treatment of herpes zoster, which can effectively reduce the degree of neuropathic pain and improve the inflammatory response of patients, and the medication is safer.
|
|
|
|
|
|
| [1] |
章荣，李威，李丹，等.肌内效贴联合加巴喷丁对头面部带状疱疹后神经痛的影响[J].中国康复医学杂志，2018，33（6）：724-726.
|
| [2] |
许纲，周朝生，唐维桢，等.围刺配合穴位注射甲钴胺对急性带状疱疹性神经痛的治疗作用[J].中国疼痛医学杂志，2020，26（2）：104-110.
|
| [3] |
奚奇，万成福，刘妍，等.普瑞巴林治疗糖尿病合并带状疱疹后神经痛的临床疗效观察[J].实用药物与临床，2017，20（7）：816-818.
|
| [4] |
中国医师协会皮肤科医师分会带状疱疹专家共识工作组.带状疱疹中国专家共识[J].中华皮肤科杂志，2018，51（6）：403-408.
|
| [5] |
肖杰，黄国坚.桃红四物汤联合前列地尔治疗带状疱疹后遗神经痛的临床观察[J].湖南中医药大学学报，2017，37（2）：209-211.
|
| [6] |
张颖，顾晓虹，朱涛.带状疱疹后遗神经痛的脊髓发病机制的研究进展[J].医学综述，2017，23（21）：4256-4261.
|
| [7] |
冯卫国，王锰.龙胆泻肝胶囊联合氦氖激光治疗带状疱疹临床疗效及对外周血T 淋巴细胞亚群、PGE2 和细胞因子的影响[J].中华中医药学刊，2018，36（11）：2763-2766.
|
| [8] |
申宇鸿，钱青，高春岩，等.点刺拔罐配合氦氖激光联合泛昔洛韦治疗早期带状疱疹疗效观察[J].现代中西医结合杂志，2019，28（3）：85-88.
|
| [9] |
王宇，贺达，沈玉杰.血府逐瘀胶囊联合干扰素治疗带状疱疹后遗神经痛的临床研究[J].现代药物与临床，2019，34（5）：1364-1367.
|
| [10] |
倪隽，陈淑珍.乌苯美司抗肿瘤作用研究进展[J].中国医药生物技术，2018，13（5）：70-73.
|
| [11] |
虞红，程纪群，李志强.复方甘草酸苷片降低带状疱疹后遗神经痛的疗效观察[J].实用皮肤病学杂志，2017，10（1）：22-24.
|
| [12] |
杨丽云，黄尧洲，郎娜.疏风解毒汤药对带状疱疹临床疗效、后遗神经痛及炎性细胞因子的影响[J].中国中医急症，2017，26（8）：1457-1459.
|
| [13] |
薛晓芳，赵静.普瑞巴林胶囊联合丁丙诺啡透皮贴治疗带状疱疹后神经痛应用研究[J].陕西医学杂志，2017，46（5）：593-595.
|
| [14] |
杜仁峰，郭朝晖.胶质细胞介导的神经炎性反应与神经病理性疼痛研究进展[J].疑难病杂志，2018，17（1）：91-94，100.
|
| [15] |
龚少智，黄发清，鲁昌宇，等.复方利多卡因乳膏联合普瑞巴林治疗带状疱疹后神经痛35例临床观察[J].安徽医药，2020，24（3）：597-599.
|
|
|
|
