|
|
Effect comparison of non-fusion stable elastic rod fixation system and nucleus pulposus removal intervertebral fusion pedicle screw rod fixation system in the treatment of lumbar degeneration |
YE Jun WANG Hai-tao |
Department of Orthopedics, Fuyong People′s Hospital of Bao′an District in Shenzhen City, Guangdong Province, Shenzhen 518103, China |
|
|
Abstract Objective To compare the effect of non-fusion stable elastic rod fixation system and nucleus pulposus removal intervertebral fusion pedicle screw rod fixation system in the treatment of lumbar degeneration.Methods A total of 40 patients with severe lumbar degeneration who required surgery in Fuyong People′s Hospital of Bao′an District in Shenzhen City from December 2016 to June 2018 were selected as the research objects.They were divided into the dynamic fixation group and the fusion fixation group according to the random lottery method, with 20 cases in each group.Patients in the dynamic fixation group were treated with pedicle elastic rod internal fixation system without removing the nucleus pulposus, and patients in the fusion fixation group were routinely treated with nucleus pulposus removal intervertebral fusion pedicle screw rod system internal fixation.The visual analogue scale (VAS) of low back pain, lower extremity pain, the Oswestry dysfunction (ODI) index and overall lumbar spine mobility before and after surgery, and incidence of postoperative complications were compared between the two groups.Results All 40 patients successfully completed the operation and were followed up after the operation.There were no statistically significant differences in the VAS score, ODI index and the overall lumbar spine mobility between the two groups at three days after operation(P>0.05).At six months after operation, the VAS score and ODI index of the dynamic fixation group were lower than those of the fusion fixation group, the differences were statistically significant (P<0.05).At 12 and 18 months after surgery, there were no significant differences in the VAS score and ODI index between the two groups (P>0.05).At 6,12, and 18 months after surgery, the overall lumbar spine mobility of the dynamic fixation group was higher than that of the fusion fixation group, and the difference was statistically significant (P<0.05).The lumbar spine pain, function and mobility were improved in the two groups at 6, 12, and 18 months after surgery compared with this group at three days after surgery, and the differences were statistically significant (P<0.05).No serious complications occurred in both groups.Conclusion Both the non-fusion stable elastic rod fixation system and the nucleus pulposus removal intervertebral fusion pedicle screw rod fixation system are effective surgical methods for the treatment of lumbar degeneration,and they can achieve good surgical results.The dynamic fixation group has the advantages of rapid relief of pain, quick recovery of overall postoperative lumbar spine mobility, large postoperative lumbar spine overall mobility, reduced incidence of degeneration of adjacent segments, and rehydration of nucleus pulposus after surgery.But the dynamic fixed group also has stress and deformation of elastic rods.
|
|
|
|
|
[3] |
温永福,朱立新,闵少雄,等.ISOBAR TTL 半坚强动态内固定与坚强内固定治疗腰椎退行性疾病临床疗效的对比分析[J].中国矫形外科杂志,2011,19(5):373-377.
|
[4] |
游浩,刘洋,李明辉,等.使用Bioflex 系统治疗腰椎退变性疾病的临床分析[J].中国骨与关节损伤杂志,2012,27(3):254-255.
|
[5] |
陈博来,许鸿智,林颖,等.动态稳定系统治疗腰椎退行性疾病初期疗效报道[J].中国矫形外科杂志,2011,19(7):537-540.
|
[1] |
Silagi ES,Novais EJ,Bisetto S,et al.Lactate Efflux from Intervertebral Disc Cells is Required for Maintenance of Spine Health[J].J Bone Miner Res,2020,35(3):550-570.
|
[2] |
Priyadarshani P,Li Y,Yao L.Advances in biological therapy for nucleus pulposus regeneration[J].Osteoarthritis Cartilage,2016,24(2):206-212.
|
[6] |
黄道余.Dynesys 动态内固定治疗腰椎退行性疾病生物力学特点与邻近节段退变的关系[J].中国组织工程研究,2019,23(24):3895-3900.
|
[7] |
Hoppe S,Schwarzenbach O,Aghayev E,et al.Long-term Outcome After Monosegmental L4/5 Stabilization for Degenerative Spondylolisthesis With the Dynesys Device[J].Clin Spine Surg,2016,29(2):72-77.
|
[8] |
Chen Z,Peng B,Li D,et al.Minimum 5-year follow-up study on the effects of the Wallis dynamic stabilization system in the treatment of lumbar degenerative disease[J].Chin Med J(Engl),2014,127(20):3587-3591.
|
[9] |
Ahmed A,Jawed A,Venkatesan M,et al.Encouraging Medium-term Results of Wallis Second Generation Dynamic Stabilisation Device[J].Ortop Traumatol Rehabil,2018,20(2):149-156.
|
[10] |
Wu H,Pang Q,Jiang G.Medium-term effects of Dynesys dynamic stabilization versus posterior lumbar interbody fusion for treatment of multisegmental lumbar degenerative disease[J].J Int Med Res,2017,45(5):1562-1573.
|
[11] |
Gan Y,Li P,Wang L,et al.An interpenetrating networkstrengthened and toughened hydrogel that supports cellbased nucleus pulposus regeneration[J].Biomaterials,2017,136:12-28.
|
[12] |
Zhou X,Wang J,Huang X,et al.Injectable decellularized nucleus pulposus-based cell delivery system for differentiation of adipose-derived stem cells and nucleus pulposus regeneration[J].Acta Biomater,2018,81:115-128.
|
[13] |
范东伟,陈仲强.椎间盘再生的外科治疗策略[J].中华外科杂志,2009,47(14):1111-1113.
|
[14] |
Wu Y,Jia Z,Liu L,et al.Functional Self-Assembled Peptide Nanofibers for Bone Marrow Mesenchymal Stem Cell Encapsulation and Regeneration in Nucleus Pulposus[J].Artif Organs,2016,40(6):E112-E119.
|
[15] |
Hodgkinson T,Stening JZ,White LJ,et al.Microparticles for controlled growth differentiation factor 6 delivery to direct adipose stem cell-based nucleus pulposus regeneration[J].J Tissue Eng Regen Med,2019,13(8):1406-1417.
|
[16] |
Reyes-Sánchez A,Zárate-Kalfópulos B,Ramírez-Mora I,et al.Posterior dynamic stabilization of the lumbar spine with the Accuflex rod system as a stand-alone device:experience in 20 patients with 2-year follow-up[J].Eur Spine J,2010,19(12):2164-2170.
|
[17] |
Canbay S,Ataker Y,Canbulat N,et al.Effect of Posterior Dynamic Instrumentation on High-Intensity Zone in Lumbar Degenerative Disc Disease[J].Turk Neurosurg,2015,25(4):578-585.
|
[18] |
Cho BY,Murovic J,Park KW,et al.Lumbar disc rehydration postimplantation of a posterior dynamic stabilization system[J].J Neurosurg Spine,2010,13(5):576-580.
|
|
|
|