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Quick Search     Adv Search 2020 Vol. 27, No. 13 Published: 2020-05-08   4 Protective effect and mechanism of flavonoids of Ardisa japonica on liver fibrosis in rats CAO Qing-sheng; LI Zhi-chao2; HAN Li-wang Objective To study the protective effect and mechanism of flavonoids of Ardisa japonica (FAJ) on liver fibrosis.Methods Sixty rats were randomly divided into a normal control group, a model group, a high-dose of FAJ group (600 mg/kg), a medium-dose of FAJ group (400 mg/kg), and a low-dose of FAJ group (200 mg/kg), with 12 rats in each group.Hepatic fibrosis model was prepared by intraperitoneal injection of 0.5% dimethylnitrosamine.At the same time, each group with intervention was administered with FAJ once a day for 8 weeks.The general morphology of rats was observed.The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD), malondialdehyde (MDA), hyaluronic acid (HA), and laminin (LN) were tested.The changes of liver in rats were observed via hematoxylin-eosin (HE) staining, and the expression of transforming growth factor-β1 (TGF-β1),tumor necrosis factor-α (TNF-α), matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinase-1(TIMP-1) was detected using immunohistochemical methods.Results The levels of ALT, AST, MDA, HA, and LN in the serum of rats in the high and medium-dose of FAJ groups were lower than those in the model group, and the SOD levels were higher than those in the model group, the degree of inflammation and fibrosis of liver was better compared with that in the model group, the positive rates of expression of TGF-β1, TNF-α, TIMP-1 were lower than those of the model group, and the positive rates of expression of MMP-1 were higher than those of the model group, the differences were statistically significant (P＜0.05).The serum levels of ALT, AST, MDA, and LN in rats in the low-dose of FAJ group were lower than those in the model group, and the differences were statistically significant (P＜0.05).There were no significant differences in the levels of SOD or HA when compared with the model group (P＞0.05).There were no significant differences in the degree of inflammation and fibrosis compared with the model group (P＞0.05).There were no significant differences in the positive rates of expression of TGF-β1, TNF-α, MMP-1 or TIMP-1 compared with the model group (P＞0.05).Conclusion The FAJ has protective effect on liver fibrosis in a dose-related manner.The mechanism may be related to protecting liver cells, reducing the degree of inflammation, preventing the occurrence of oxidative stress, inhibiting the activation of hepatic stellate cells, and decreasing the formation of extracellular matrix. 2020 Vol. 27 (13): 4-8 [Abstract] ( 81 ) HTML (53 KB)  PDF  (0 KB)  ( 13 ) 9 Application value of dual bioelectrical impedance analysis in detecting visceral fat area in patients with type 2 diabetes mellitus WU Jin-zhi； ZHENG Gui-an； LAI Peng-bin； XIE Liang-xiao； ZHA Xiao-yun Objective To investigate the application value of dual bioelectrical impedance analysis (dBIA) in detecting visceral fat area (VFA) in patients with type 2 diabetes mellitus (T2DM).Methods From January 2017 to January 2019,128 patients with T2DM were selected from the department of endocrinology of our hospital.The blood biochemical analysis was performed and the history of hypertension and/or dyslipidemia was recorded.According to brain natriuretic peptide (BNP) level, the patients were divided into the BNP≥100 pg/ml group and the BNP＜100 pg/ml group.VFA was measured using dBIA and computed tomography (CT) on the same day.Pearson′s correlation analysis was used to detect the relationship between VFA measured by dBIA (VFA-dBIA) and VFA measured by CT (VFA-CT).Multiple regression analysis was performed to detect multiple factors related to measurement error of VFA.The receiver operating characteristic (ROC) analysis for the VFA was used to detect the presence of comorbid hypertension and/or dyslipidemia with T2DM.The areas under the curve (AUC) were also calculated and compared.Results The percent measurement error between VFA-dBIA and VFA-CT in the BNP ≥100 pg/ml group was significantly higher than that in the BNP＜100 pg/ml group ([39.2±8.1]% vs.[24.1±6.4]%, P=0.031).After excluding patients with BNP≥100 pg/ml, the VFA-dBIA was significantly correlated with the VFA-CT (r=0.917, P＜0.0001).The AUC in the ROC analysis for the VFA-dBIA to detect the presence of comorbid hypertension and/or dyslipidemia with T2DM was almost equivalent to that for the VFA-CT.Conclusion In patients with T2DM without potential heart failure, estimation of the VFA-dBIA significantly correlates with VFA-CT, and VFA-dBIA has the same diagnostic efficacy as VFA-CT in identifying diabetes mellitus with comorbid hypertension and/or dyslipidemia. 2020 Vol. 27 (13): 9-12转17 [Abstract] ( 82 ) HTML (42 KB)  PDF  (0 KB)  ( 12 ) 13 Study on the correlation between single nucleotide polymorphisms of APE1 gene and clinical phenotype of hepatocellular carcinoma LU Xiao-hua ； ZHU Xiao-qing； YUAN Hong-xin； CHU Yu-shan Objective To investigate the correlation between the single nucleotide polymorphisms of APE1 gene at the locus of -141T/G and 148Asp/Glu and different clinical phenotypes of hepatocellular carcinoma.Methods A total of 125 patients newly diagnosed with hepatocellular carcinoma who were hospitalized in the Interventional Radiology Department of the Affiliated Hospital of Nantong University from January 1 to December 31, 2018 were selected as the research objects to extract genomic DNA.The panel high-throughput data analysis was adopted to conduct APE1 genotyping and the correlation between each genotype and the clinical phenotype of hepatocellular carcinoma was analyzed.Results At locus -141, patients with heterozygous mutant genotype TG had an increased risk of later stage than patients with wild-type TT (OR=4.513, 95%CI：1.411-14.445, P＜0.05), the patients with homozygous mutant genotype GG had an increased risk of later stage than patients with wild-type TT (OR=4.444, 95%CI：1.217-16.233, P＜0.05),and the risk of later stage in patients with mutant genotype TG+GG was higher than that in patients with wild type TT (OR=4.491, 95%CI：1.457-13.848, P ＜0.05).There was no significant difference in the risk of stages of each genotype at locus 148 (P＞0.05).At locus -141,patients with heterozygous mutant genotype TG had an increased risk of portal vein invasion compared with patients with wild-type TT (OR=3.091, 95%CI：1.019-10.064, P＜0.05), the patients with homozygous mutant genotype GG had an increased risk of portal vein invasion compared with patients with wild-type TT (OR=3.789, 95%CI：1.025-14.009, P＜0.05), and the risk of portal vein invasion in patients who carried the mutant genotype TG+GG was higher than that in patients with wild type TT (OR=3.302, 95%CI：1.061-10.276, P＜0.05).There was no significant difference in the risk of portal vein invasion among all genotypes at locus 148 (P＞0.05).There was no significant difference in the risk of lymph node metastasis among genotypes at locus -141 (P＞0.05).At locus 148, patients with homozygous mutation GG had an increased risk of lymph node metastasis compared patients with wild-type TT (OR=3.500, 95%CI：1.018-12.03, P＜0.05).At locus -141, patients with homozygous mutation GG had an increased risk of distant metastasis compared with patients with wild-type TT (OR=5.667, 95%CI：1.074-29.891, P＜0.05).There was no significant difference in the risk of distant metastasis among all genotypes at locus 148 (P＞0.05).Conclusion The single nucleotide polymorphisms of APE1 gene are correlated with clinical phenotypes of hepatocellular carcinoma such as BCLC stage,portal vein invasion, lymph node metastasis and distant metastasis. 2020 Vol. 27 (13): 13-17 [Abstract] ( 72 ) HTML (38 KB)  PDF  (0 KB)  ( 10 ) 18 Clinical study of pulse variability index in guiding laparoscopic intestinal tumor surgery LUO Rui ； ZHU Yan-hong； LIAO Fei Objective To explore the clinical application value of goal-directed fluid therapy under the guidance of pulse variability index (PVI) in laparoscopic intestinal tumor surgery.Methods Forty patients who underwent elective laparoscopic intestinal tumor surgery in our hospital from January 2018 to July 2019 were selected as the research subjects, and they were divided into group S and group D according to the random number table method, 20 cases in each group.Patients in group S were guided by PVI for intraoperative fluid therapy, and patients in group D were judged comprehensively for intraoperative fluid therapy based on indicators such as heart rate (HR), blood pressure, and central venous pressure (CVP).The hemodynamic indicators (mean arterial pressure [MAP], HR, CVP, PVI, pulse perfusion index[PI])at the following time points were recorded in the two groups of patients,like room admission(T1),after anesthesia intubation (T2), 5 minutes after the pneumoperitoneum was established (T3), when the tumor was removed (T4),5 minutes after the deflation of the abdomen (T5), and the completion of the surgery (T6).The surgery time, total infusion volume, urine volume, blood loss and intraoperative anesthetic drug use of the two groups were recorded, and the postoperative exhaust time, the incidence of lung and gastrointestinal adverse events in the two groups were observed.Results There were no significant differences in MAP, HR, CVP, PVI, and PI at T1-T3 and T5-T6 between the two groups (P＞0.05).At T4, the HR of group S ([64.00±6.62]times/min) was lower than that of group D ([73.89±8.08]times/min), and the difference was statistically significant (P＜0.05).There were no statistically significant differences in surgery time, urine volume, blood loss and intraoperative anesthetic drug use between the two groups (P ＞0.05).The total infusion volume of patients in group S([2502.53±347.62]ml) was less than that in group D ([2778.60±366.62]ml), and the difference was statistically significant (P＜0.05).The postoperative exhaust time of group S ([56.52±29.66]h) was shorter than that of group D ([82.67±40.71]h), and the difference was statistically significant (P＜0.05).There was no statistically significant difference in the incidence rate of lung adverse events between the two groups (P＞0.05).The incidence rate of gastrointestinal adverse events in group S (5.0%) was lower than that in group D (30.0%), and the difference was statistically significant (P＜0.05).Conclusion PVI used to guide the liquid therapy in laparoscopic intestinal tumor surgery can reduce the fluid input while maintaining the stability of the circulation, and it is beneficial to the rapid recovery of patients after surgery and can reduce the incidence of gastrointestinal adverse events, which is worthy of clinical recommendation. 2020 Vol. 27 (13): 18-21 [Abstract] ( 78 ) HTML (47 KB)  PDF  (0 KB)  ( 11 ) 22 Research progress in treatment of chronic obstructive pulmonary disease by traditional Chinese medicine external therapy WANG Yu； CHEN Feng； HONG Min-shen For chronic obstructive pulmonary disease (COPD), western medicine mostly adopts COPD global strategy(GOLD) graded treatment, which cannot reverse the progressive decrease of pulmonary function and brings great side effects.In recent years, with the gradual deepening of people′s understanding of COPD, the traditional Chinese medicine(TCM) external treatment has made a significant effect in the treatment of COPD.This paper gives a brief overview of the research progress in the treatment of COPD by TCM external therapy in recent years to provide more basis for clinical application.Databases such as CNKI, Wanfang Data, CQVIP have been searched and the representative related literatures in recent 5 years at home and abroad have been selected.The experimental and clinical research progress in the treatment of chronic obstructive pulmonary disease by TCM external treatment has been summarized from the aspects of acupuncture, moxibustion, acupoint application, acupoint embedding and so on.It is shown that the TCM external therapy can improve the clinical symptoms, pulmonary function and quality of life of patients with chronic obstructive pulmonary disease, and is an effective and safe method of treatment.In the meantime, this paper COPD and deficiencies in the current studies, thus provides a way of thinking for further research. 2020 Vol. 27 (13): 22-24转29 [Abstract] ( 88 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 25 Research progress on continuous nursing care of patients with coronary heart disease after percutaneous coronary intervention GUAN De-juan； LI Chun-rong At this stage, with the change of people′s living habits and eating habits, the incidence and mortality of coronary heart disease in China have increased, and the age of onset shows a younger trend.Percutaneous coronary intervention (PCI) is one of the important methods for the treatment of coronary heart disease, which uses cardiac catheterization to dredge the coronary artery lumen with stenosis or even occlusion, so as to improve the blood perfusion of ischemic myocardium.At present, it has become one of the importart methods to treat partents with coronary heart disease.However, the occurrence of major adverse cardiac events (MACE) such as restenosis, stent thrombosis and new heart failure after PCI limits the long-term efficacy of PCI.To address this problem, the European Society of Cardiology guidelines recommend that patients after PCI need routine antiplatelet therapy to effectively inhibit platelet aggregation and reduce the incidence of long-term MACE events.In addition, due to the acceleration of population aging, the limited level of medical knowledge and regional development differences, poor drug compliance is common in PCI patients,which significantly reduces the short-term and long-term prognosis of PCI patients.In recent years, more and more attention has been paid to the application of continuous nursing in clinical practice.It usually refers to the continuous nursing from hospital to family, through a series of effective intervention measures for patients, to ensure that they benefit from continuous care in different situations.This paper summarized the research progress of continuous nursing after PCI for patients with coronary heart disease, and provided reference basis for clinical nursing. 2020 Vol. 27 (13): 25-29 [Abstract] ( 87 ) HTML (43 KB)  PDF  (0 KB)  ( 12 ) 30 Research progress in occupational hazards and protection of nurses in infectious diseases in the new era WANG Xiao-yi The infectious department is the place where infectious disease patients are concentrated, the working environment is special, and the particularity of the disease of the service object.If personal protection is not paid attention to during the operation, the risk of occupational hazards is greater and the physical and mental health of nurses will be affected.The development of medical science and technology and the change of medical mode in the new era have led to changes in the pattern of infectious department in hospitals.Nurses in infectious department face higher occupational hazards than other departments in hospitals.Therefore, clinical practice should summarize the risk factors leading to occupational hazards of infectious nurses in the new era and explore the corresponding protective measures to reduce the incidence of occupational hazards.This article reviews the occupational hazards of infectious nurses in the new era and the protective measures. 2020 Vol. 27 (13): 30-32 [Abstract] ( 93 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 33 New advances in diabetic retinopathy treatment LI Ya-li； CHEN Li-li Diabetic retinopathy (DR) is one of the most common and severe microvascular complications of type 2 diabetes, and the leading cause of blind as well.It seriously affects people′s health and quality of life, which has gained more and more attention.In the early stage, DR doesn′t show any symptoms and the treatment is poor.Therefore, it is the hot research topic how to treat DR effectively as soon as possible.This paper is the review of recent advances in diabetic retinopathy treatment. 2020 Vol. 27 (13): 33-36 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 37 Investigation on the efficacy and safety of Atorvastatin in the treatment of subacute subdural hematoma HUANG An-jin Objective To investigate the clinical effect of Atorvastatin in the treatment of subacute subdural hematoma.Methods A total of 50 patients with subacute subdural hematoma in our hospital from March 2017 to March 2019 were divided into the observation group and the control group according to the digital parity method, 25 cases in each group.The control group was drilled at the thickest part of the skull hematoma, and the observation group was treated with Atorvastatin.The therapeutic effect, adverse reactions and recurrence, neurological function score and activity of daily life score of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group, the rates of adverse reactions and recurrence were lower than those of the control group, and the scores of neurological function and activities of daily life after treatment were lower than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Atorvastatin is not only effective in the treatment of subacute subdural hematoma, but also can reduce the incidence of adverse reactions, reduce the recurrence rate, improve the neurological function, and improve the ability of daily life, which has significant clinical value. 2020 Vol. 27 (13): 37-39 [Abstract] ( 73 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 40 Influence of remote ischemic preconditioning on the prognosis of patients with cerebral infarction LIU Hua； HUANG Bin-ying； WANG Yan-chan Objective To discuss the influence of remote ischemic preconditioning (RIPC) on the prognosis of patients with cerebral infarction.Methods A total of 104 cerebral infarction patients treated in our hospital from January 2015 to January 2016 were selected as the research objects.Patients were divided into the observation group and the control group according to the computer random method, 52 cases in each group.Patients in the observation group received conventional drug therapy combined with RIPC nursing intervention, and patients in the control group received conventional nursing+drug therapy.The national institutes of health stroke scale (NIHSS) scores of the two groups of patients before and after intervention were evaluated, and the cerebral ischemia recurrence rate, quality of life score, and total satisfaction were compared between the two groups.Results There was no significant difference in NIHSS score between the two groups of patients before intervention (P＞0.05).After intervention, the NIHSS score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Among patients in the observation group, 1 case (1.92%) of cerebral ischemia recurred confirmed by cranial magnetic resonance examination 6 months after attack, and 8 cases (15.38%) in the control group.The recurrence rate of cerebral ischemia in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).After 6 months of intervention, the physical function, social function, mental health, energy and general health status scores of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The total satisfaction of patients in the observation group (96.15%) was higher than that in the control group (65.38%), and the difference was statistically significant (P＜0.05).Conclusion The implementation of RIPC can effectively improve the prognosis of patients with cerebral infarction, improve the life quality of patients, and reduce the risk of cerebral ischemia recurrence. 2020 Vol. 27 (13): 40-43 [Abstract] ( 76 ) HTML (35 KB)  PDF  (0 KB)  ( 15 ) 44 Clinical effect of arthroscopy combined with minimally invasive incision in the treatment of dislocation of knee joint complicated with multiple ligament injury LI Zheng-nan; WANG Yi-hai; YANG Kang-hua; LUO Zhi-huan; CAI Xing-jian; ZHU Dao-xin; XIAO Shi-liang Objective To investigate the clinical effect of arthroscopy combined with minimally invasive incision in the treatment of dislocation of knee joint complicated with multiple ligament injury.Methods From January 2017 to January 2019, 60 patients with dislocation of knee joint complicated with multiple ligament injury treated in our hospital were selected as the subjects, and divided into observation group (n=30) and control group (n=30) according to the method of drawing lots.The control group was treated with conventional orthopedic surgery, and the observation group was treated with arthroscopy combined with minimally invasive incision.The therapeutic effect, recovery time of knee joint function and complications were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).The recovery time of knee joint function in the observation group was shorter than that in the control group, the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Arthroscopy combined with minimally invasive incision is more effective in the treatment of dislocation of knee joint with multiple ligament injury,which can effectively improve the therapeutic effect, shorten the recovery time of patients, and the incidence of complications is low. 2020 Vol. 27 (13): 44-46转50 [Abstract] ( 83 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 47 Clinical effect of operation under the guidance of theory of damage control in the treatment of pelvic fracture combined with skin and soft tissue injury HUANG Sheng； LIANG Xian-zhang Objective To study the clinical effects of operation under the guidance of theory of damage control (TDC)in the treatment of pelvic fracture combined with skin and soft tissue injury.Methods The clinical data of 350 cases of pelvic fracture combined with skin and soft tissue injury in our hospital from February 2016 to December 2018 were analyzed retrospectively.According to different treatment methods,the patients were divided into control group(175 cases)and observation group (175 cases).The patients in the control group were treated by conventional operation, while those in the observation group were treated by operation under the guidance of TDC.The operation time, intraoperative bleeding volume, total hospitalization time, treatment effect and complications between the two groups were compared.Results The operation time and hospitalization time of the patients in the observation group were shorter than those in the control group, and the amount of bleeding in the operation was less than that in the control group, the differences were statistically significant (P＜0.05).The excellent and good rate of treatment in the observation group was 84.4%,higher than 53.7% in the control group, the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was 4.0%, lower than 35.4% in the control group, the difference was statistically significant (P＜0.05).Conclusion Under the guidance of TDC, the operation for pelvic fracture with systemic skin and soft tissue injury has a significant effect.Compared with conventional operation, it can significantly shorten the operation time, reduce the amount of intraoperative bleeding, shorten the length of stay and reduce complications, which is worth popularizing and applying in clinical practice. 2020 Vol. 27 (13): 47-50 [Abstract] ( 86 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 51 Application effect of mastectomy in segment combined with intraoperative rapid freezing in the treatment of breast tumors OUYANG Zhen-fu； LIAO Sheng-you； WANG Yue Objective To investigate the effect of mastectomy in segment combined with intraoperative rapid freezing in the treatment of breast tumors.Methods Clinical data of 80 breast tumor patients treated in our hospital from March 2017 to March 2019 were retrospectively analyzed.The clinical data were collated and analyzed.They were divided into control group and observation group according to the different surgical methods, with 40 cases in each group.Patients in the control group were treated with traditional breast tumor resection, and patients in the observation group were treated with mastectomy in segment combined with intraoperative rapid freezing.The surgical indicators, postoperative aesthetics and quality of life were compared between the two groups.Results The amount of bleeding during surgery in the observation group was less than that in the control group, the waiting time for pathological results, postoperative hospital stay, incision healing time, and postoperative pain time in the observation group were shorter than those in the control group, and the excellent and good rate of aesthetics in the observation group was higher compared with that in the control group, with statistical significance differences (P＜0.05).In the observation group, the scores of environmental, social, physica, psychological, and comprehensive in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Mastectomy in segment combined with intraoperative rapid freezing in the treatment of breast tumors can shorten the waiting time for pathological results and hospital stay, promote recovery, and improve postoperative aesthetics as well as the quality of life of patients. 2020 Vol. 27 (13): 51-53转57 [Abstract] ( 84 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 54 Application effect of targeted lymphadenectomy in patients undergoing laparoscopic radical gastrectomy ZHANG Wen-tao Objective To investigate the application effect of targeted lymphadenectomy in patients undergoing laparoscopic radical gastrectomy.Methods Eighty-six patients who underwent laparoscopic radical gastrectomy in our hospital from March 2016 to March 2019 were selected as the subjects.According to simple randomization, they were divided into directional group (43 cases) and conventional group (43 cases).Patients in the directional group were treated with targeted lymphadenectomy, and patients in the conventional group were treated with conventional lymphadenectomy.The surgical indexes of the two groups were compared, and the micrometastases in the blood and abdominal cavity of the two groups were observed.Results The operation time and postoperative hospitalization time of the directional group were shorter than those of the conventional group, the intraoperative blood loss was less than that of the conventional group, and the differences were statistically significant (P＜0.05).The postoperative micrometastasis rates of blood and abdominal cavity in the directional group were lower than those of the conventional group, and the differences were statistically significant (P＜0.05).There were no significant differences between the two groups in the way of anastomosis, the number of lymphadenectomy, the distance between the margin and the tumor, and the time of anal exhaust (P＞0.05).There were no significant differences in preoperative micrometastasis rates of blood and abdominal cavity between the two groups (P＞0.05).There were no significant differences in micrometastasis rates of blood and abdominal cavity in the directional group before and after opration (P＞0.05).Conclusion Targeted lymphadenectomy in laparoscopic radical gastrectomy can not only shorten the operation time, reduce the amount of bleeding, but also reduce the risk of recurrence by reducing the risk of micrometastasis. 2020 Vol. 27 (13): 54-57 [Abstract] ( 85 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 58 Effect of Gemcitabine combined with Cisplatin in the treatment of anthracycline-resistant and taxane-resistant advanced breast cancer HUANG Jun-cong Objective To explore the effect of Gemcitabine combined with Cisplatin in the treatment of anthracyclineresistant and taxane-resistant advanced breast cancer.Methods A total of 76 patients with advanced anthracycline-resistant and taxane-resistant breast cancer who were admitted to our hospital from March 2017 to June 2019 were selected as the subjects.They were divided into two groups according to the random number table method, with 38 cases in each group.In the control group, Vinorelbine combined with Cisplatin was used, and in the experimental group,Gemcitabine combined with Cisplatin was adopted.The treatment effect, quality of life, and adverse reactions were compared between the two groups.Results The disease control rate (DCR) and objective response rate (ORR) of the experimental group were 50.00% and 86.84%, which were higher than those of the control group accounting for 26.32%and 44.74%, respectively, and the differences were statistically significant (P＜0.05).The Karnofsky performance status(KPS) score was (85.56±12.86) points, which was higher than that of the control group ([75.78±12.48]points), and the difference was statistically significant (P＜0.05).There were no significant differences in the incidence of anemia, fever,hair loss, renal impairment or liver impairment (P＞0.05).Conclusion Gemcitabine combined with cisplatin is safe for patients with anthracycline-resistant and taxane-resistant advanced breast cancer. 2020 Vol. 27 (13): 58-60转70 [Abstract] ( 77 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 61 Effect of pelvic floor rehabilitation therapy combined with pelvic floor muscle training on pelvic floor function of parturient women YANG Gui-xia Objective To explore the effect of pelvic floor rehabilitation combined with pelvic floor muscle training on the pelvic floor function of parturient women.Methods A total of 60 primiparas diagnosed and treated in our hospital from May 2018 to may 2019 were selected as the research objects for retrospective analysis.According to the different research methods, they were divided into control group (n=30) and study group (n=30).The control group was treated with pelvic floor rehabilitation therapy instrument alone，and the study group was treated with pelvic floor rehabilitation therapy combined with pelvic floor muscle training.The lactation initiation time, duration of lochia, pelvic floor muscle tone score, urinary incontinence score between two groups were compared.Results The time of lactation initiation and duration of lochia in the study group were shorter than that in the control group, with statistical differences (P＜0.05).After treatment, the score of pelvic floor muscle tension in the study group was higher than that in the control group, with statistical difference (P＜0.05), while the score of urinary incontinence was lower than that in the control group, with statistical difference (P＜0.05).Conclusion Pelvic floor rehabilitation therapy combined with pelvic floor muscle training has a positive effect on the recovery of pelvic floor function of parturient women, which can promote the early lactation, discharge lochia and relieve the symptoms of urinary incontinence, it can be popularized in clinical practice. 2020 Vol. 27 (13): 61-63 [Abstract] ( 95 ) HTML (30 KB)  PDF  (0 KB)  ( 14 ) 64 Application effect of caring after caring for family planning care after artificial abortion LAI Jian; CHEN Cui-lian; CHEN Yi-lian Objective To investigate the effect of post-abortion care (PAC) in family planning care after artificial abortion.Methods A total of 364 patients who underwent artificial abortion in our hospital from April 2017 to April 2019 were selected as the study subjects, they divided into observation group and control group according to random number table method, 182 cases in each group.The control group underwent routine flow health education, and the observation group was followed by PAC guidance.The awareness of contraceptive knowledge of contraceptive knowledge,complication rate, negative emotional severity and patient satisfaction were compared between the two groups.Results There was no significant difference in the awareness of contraceptive knowledge between the two groups before intervention (P＞0.05).The awareness of contraceptive knowledge after intervention of the observation group was higher than that of control group, the difference was statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).The negative emotion scores of the two groups were lower than those before the intervention (P＜0.05).The scores of anxiety and depression in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The total satisfaction of the patients in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The implementation of PAC in family planning care after induced abortion can improve the patients′ knowledge of birth control and birth control.At the same time, it can alleviate the negative emotion of patients and improve the satisfaction of patients, which is worth popularizing. 2020 Vol. 27 (13): 64-66 [Abstract] ( 83 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 67 Application of thyroxine in patients with pregnancy complicated with hypothyroidism DENG Xia-mei ; LUO Yun-shan Objective To explore the application of thyroxine in patients with pregnancy complicated with hypothyroidism.Methods A total of 96 patients with pregnancy complicated with hypothyroidism who were treated in our hospital from August 2017 to July 2019 were selected.They were divided into the control group and the study group according to the digital parity method, 48 cases in each group.The control group was treated with conventional iodine supplementation, while the study group was given thyroxine.The thyroid hormone level, progesterone level, and maternal and child outcomes were compared between the two groups.Results There were no significant differences in serum thyroid stimulating hormone (TSH) level, free thyroid hormone (FT4) level, and free triodothyronine (FT3) level between the two groups before treatment (P＞0.05).After treatment, the TSH level in the study group was lower than that in the control group, the FT4 and FT3 levels in the study group were higher than those in the control group, with statistical differences (P＜0.05).There was no statistically significant difference in the progesterone level between the two groups before treatment (P＞0.05).The progesterone level in the study group was higher than that in the control group after treatment, with statistical difference (P＜0.05).There was no statistically significant difference in the hypersensitive C-reactive protein (hs-CRP) level between the two groups before treatment (P＞0.05).The hs-CRP level in the study group was lower than that in the control group after treatment, with statistical difference (P＜0.05).The total incidence of complications, such as gestational hypertension, intrahepatic cholestasis of pregnancy, and fetal distress, in the study group was lower than that in the control group, with statistical difference (P＜0.05).The incidences of preeclampsia, early abortion and fetal malformation in the study group were lower than those in the control group, with statistical differences (P＜0.05).The weight of newborns in the study group was higher than that in the control group, with statistical difference (P＜0.05).Conclusion Thyroxine can improve thyroid hormone and elevate progesterone level in patients with pregnancy complicated with hypothyroidism.It can also improve maternal and infant outcomes, with significant clinical value. 2020 Vol. 27 (13): 67-70 [Abstract] ( 90 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 71 Clinical effect of perinatal health care and calcium supplementation to prevent pregnancy-induced hypertension syndrome PENG Kai-xin Objective To explore the clinical effects of perinatal health care and calcium supplementation to prevent pregnancy-induced hypertension syndrome.Methods A total of 100 pregnant women admitted to our hospital from February 2018 to May 2019 were selected as research subjects.They were divided into control group (n=50) and observation group (n=50) according to the random number table method.In the observation group, health care and calcium supplementation were provided during perinatal period; in the control group, regular nursing was used.After nursing,the occurrence of pregnancy-induced hypertension syndrome, blood calcium levels, pregnancy outcomes, and neonatal conditions were compared between the two groups.Results The blood calcium level of pregnant women in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The incidence of pregnancy-induced hypertension syndrome was lower than that in the control group, and the difference was statistically significant (P＜0.05).The maternal birth rate and neonatal Apgar score of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).The postpartum hemorrhage rate and the incidence of neonatal asphyxia were lower than those of the control group with statistical significance (P＜0.05).Conclusion Health care and calcium supplementation during perinatal period have a positive effect on the prevention of pregnancy-induced hypertension syndrome, and it is worthy of extensive promotion and implementation. 2020 Vol. 27 (13): 71-73 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 74 Effect of Oxytocin combined with Carprostol Tromethamine Injection on postpartum hemorrhage in cesarean section of scar uterus LI Xiao-ling Objective To investigate the effect of Oxytocin combined with Carprostol Tromethamine Injection on postpartum hemorrhage in scar uterus (SU).Methods Sixty-two patients with SU who were scheduled to undergo cesarean delivery from October 2017 to November 2018 in our hospital were selected.The patients were divided into observation group (n=30) and control group (n=32) according to the principle of computer randomization.The observation group received Oxytocin combined with Carprostol Tromethamine Injection, the control group received Oxytocin treatment, the hemostatic effect of the two groups of patients after treatment were observed, and the number of postpartum hemorrhage was counted.Results The amount of bleeding after 2 and 24 hours of postpartum in the observation group were lower than those in the control group, the duration of postpartum hemorrhage was shorter than that in the control group, the incidence of postpartum hemorrhage of the observation group was lower than that in the control group.The differences were statistically significant (P＜0.05).Conclusion The prophylactic application of Oxytocin combined with Carprostol Tromethamine Injection in patients with SU can reduce the probability of postpartum hemorrhage after delivery and reduce the amount of postpartum hemorrhage. 2020 Vol. 27 (13): 74-76 [Abstract] ( 91 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 77 Application effect of mechanical ventilation in prone position in treatment of children with severe pneumonia CHEN Neng-hui Objective To explore the application effect of mechanical ventilation in the prone position in the treatment of children with severe pneumonia.Methods A total of 120 children who were treated for severe pneumonia in our hospital from April 2018 to April 2019 were selected.They were divided into the control group and the experimental group using computer generated random numbers, 60 cases in each group.The control group was treated with conventional mechanical ventilation in the supine position, while the experimental group was given mechanical ventilation in the prone position.The arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), mean arterial pressure (MAP), dynamic pulmonary compliance (Cdyn), and treatment satisfaction were compared between the two groups before and after treatment.Results The PaO2 and Cdyn levels of the experimental group after treatment were higher than those of the control group, and the PaCO2 was lower than that of the control group, with statistical differences (P＜0.05).The total treatment satisfaction rate of the experimental group (93%) was higher than that of the control group (80%), with statistical difference (P＜0.05).Conclusion Mechanical ventilation in the prone position can effectively improve the treatment effect and overall satisfaction in the treatment of children with severe pneumonia.It can be used for reference in the treatment of severe pneumonia in children. 2020 Vol. 27 (13): 77-79 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 80 Application effect comparison of Misoprostol and COOK cervical dilatation balloon in promoting cervical ripening in late pregnancy JIANG Yan-yan; MIAO Li-lin Objective To compare the effect of Misoprostol and cook cervical dilatation balloon in promoting cervical ripening in late pregnancy.Methods Ninety late pregnant women with indications of induced labor and immature cervix from January 2016 to July 2019 in our hospital were selected as research objects.They were randomly divided into 40 cases of Misoprostol group (group A), 50 cases of COOK balloon group (group B) by drawing.The cervical score before and after treatment, delivery outcome, complications and neonatal condition of pregnant women were compared between two groups.Results The cervical score of the two groups after treatment were higher than those before treatment, the differences were statistically significant (P＜0.05).The effective rate of promoting cervical maturation in group B was higher than that in group A (P＜0.05).The incidence of uterine contraction overfrequency and fetal distress in group A were higher than that in group B (P＜0.05).There were no significant differences in cesarean section rate, postpartum hemorrhage rate and neonatal asphyxia between the two groups (P＞0.05).Conclusion COOK cervical dilatation balloon and Misoprostol can significantly improve cervical ripening, but COOK cervical dilatation balloon is more safe and worthy of clinical application. 2020 Vol. 27 (13): 80-82 [Abstract] ( 95 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 83 Application effect of touch nursing on the weaning time of baby′s breast milk and physical growth ZHOU Li Objective To explore the effect of applying touch nursing on the weaning time of baby′s breast milk and physical growth.Methods A total of 66 babies who were admiteed to our hospital from April 2017 to January 2019 were selected as the research objects.By random number table method, they were divided into control group (n=33) and observation group (n=33).The babies in the control group received daily nursing, and in the observation group, they were provided with touch nursing.The Gatzel score, physical development indicators (head circumference, length, and weight), daily sleep time, and weaning time from breast milk after 8 months intervention in the two groups were compared.Results The baby′s gross motor score, fine movement score, adaptive ability score, language score, and social behavior score in the observation were higher than those in the control group, with statistical differences (P＜0.05).The head circumference was longer than that of the control group, length was higher than that of the control group, and weight was greater than that of the control group, with statistical differences (P＜0.05).The daily sleep time and weaning time in the observation group were both longer than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion The touch nursing has a positive effect on the weaning time and physical growth in babies.It can improve the baby′s Gatsel score, promote the development, and extend the daily sleep time and weaning time. 2020 Vol. 27 (13): 83-85 [Abstract] ( 86 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 86 Clinical effect of alveolar crest approach in the treatment of odontogenic maxillary sinusitis and missing teeth implant restoration MAO Jun-mu; LIU Xiao Objective To observe the clinical effect of alveolar crest approach in the treatment of odontogenic maxillary sinusitis and missing teeth implant restoration.Methods From January 2015 to December 2017, 60 patients with odontogenic maxillary sinusitis treated in our hospital were selected as research objects.They were divided into control group (30 cases) and experimental group (30 cases) according to the random number table method.The patients in control group were treated with traditional Caldwell-Luc operation, while those in experimental group were treated with alveolar crest approach.After the operation of two groups of patients, missing teeth implant restoration was performed in the corresponding area, and the effective follow-up period was 18 months for two groups of patients.The surgical conditions, total clinical effective rate of treatment, mucosal perforation rate of the maxillary sinus mucosa during the second-stage implant operation, and the recurrence rate of odontogenic maxillary sinusitis during follow-up in the two groups of patients were compared between the two groups, and the problems related to dental implant restoration at 18 months were scored.Results In the experimental group, the bleeding volume was less than that in the control group,the operation time was shorter than that in the control group, the postoperative swelling and pain score was lower than that in the control group, and the differences were statistically significant (P＜0.05).The total effective rate of treatment in the experimental group was 96.67%, which was higher than that in the control group accounting for 76.67%, and the difference was statistically significant (P＜0.05).The mucosal perforation rate of the maxillary sinus mucosa during the second-stage implant operation in the experimental group was 0.00%, which was lower than that of the control group (13.33%), and the difference was statistically significant (P＜0.05).There was no recurrence in the experi-mental group during the follow-up period, while in the control group, there was one case of recurrence at 12 and 18 months of follow-up respectively; there was no significant difference in the recurrence rate of odontogenic maxillary sinusitis between the two groups (P＞0.05).The chewing function and satisfaction scores of the patients in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion For the treatment of odontogenic maxillary sinusitis, after adopting the treatment method of alveolar crest approach and implanting the missing teeth in the corresponding area, a better clinical treatment effect can be obtained,and reduce the perforation of the maxillary sinus mucosa during the second-stage implant operation and relapse after operation, improve the chewing function of the patients, and the effect is ideal. 2020 Vol. 27 (13): 86-89 [Abstract] ( 76 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 90 Effect of functional endoscopic sinus surgery in the treatment of chronic rhinosinusitis GAO Xiang; LI Jun-zheng; WU Jian Objective To investigate the effect of functional endoscopic sinus surgery (FESS) in the treatment of chronic rhinosinusitis (CRS).Methods A total of 80 patients with CRS admitted to Dongguan Fifth People′s Hospital from January 2017 to January 2019 were selected as the study subjects.They were divided into the experimental group and the control group by the random number table method, 40 patients in each group.The experimental group was treated with FESS, while the control group was treated with traditional surgery.The total response rate of the two groups was compared.The scores of quality of life and main symptoms before and 6 months after treatment were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences between the two groups in the scores of living quality factors, such as physical pain, role physical, physical function, social function,vitality, mental health, emotional function and general health (P＞0.05).After 6 months of treatment, the scores of living quality factors, such as physical pain, role physical, physical function, social function, vitality, mental health, emotional function and general health in both groups were higher than those before treatment, and the scores of living quality factors, such as physical pain, role physical, physical function, social function, vitality, mental health, emotional function and general health in the experimental group were all higher than those in the control group, with statistically significant differences (P＜0.05).Before treatment, there were no significant differences between the two groups in the scores of major symptoms, such as nasal congestion, hyposmia,nasal secretion, dizziness, headache and facial pain (P＞0.05).The the scores of major symptoms, such as nasal congestion, hyposmia, nasal secretion, dizziness, headache and facial pain of the two groups after 6 months of treatment were all lower than those before treatment, and the scores of major symptoms, such as nasal congestion, hyposmia, nasal secretion, dizziness, headache and facial pain of the experimental group were lower than those of the control group, with statistically significant differences (P＜0.05).Conclusion FESS has a significant effect in the treatment of CRS patients.It can significantly improve the quality of life of patients and reduce the main symptoms and should be widely applied in clinical practice. 2020 Vol. 27 (13): 90-93 [Abstract] ( 73 ) HTML (40 KB)  PDF  (0 KB)  ( 11 ) 94 Clinical effect of crown repair and root canal therapy in the treatment of cracked pulpitis QIN Si-si ； CHEN Ning-ning Objective To explore the clinical effect of crown repair and root canal therapy in the treatment of cracked pulpitis.Methods A total of 300 patients with cryptic pulpitis admitted to our hospital from 2016 to June 2018 were selected as subjects in the study.They were divided into the control group (150 cases) and the study group (150 cases)according to the random number table method.Patients in the control group were treated with crown repair and root canal therapy in step by step, while patients in the study group were treated with crown repair and root canal therapy simultaneously.After treatment, the treatment effect, pain and total treatment satisfaction of the two groups were compared.Results After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The incidence of pain in the study group was lower than that of the control group, and the difference was statistically significant (P＜0.05).The total satisfaction of treatment was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion The effect of crown repair and root canal therapy in the treatment of patients with cracked pulpitis is significant, which can effectively improve the total satisfaction of treatment and improve the patients′ tooth pain, which is worthy of clinical promotion. 2020 Vol. 27 (13): 94-96转100 [Abstract] ( 66 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 97 Clinical effect comparison of intratympanic hormone injection at different time in the treatment of total frequency type profound sudden sensorineural hearing loss GUO Shuang; LI Da-wei; ZHANG Dong-mei; CUI Shi-hui Objective To compare the clinical effect of intratympanic hormone injection at different time in the treatment of total frequency type profound sudden sensorineural hearing loss.Methods Fifty-eight patients with total frequency type profound sudden sensorineural hearing loss treated in our hospital from February 2014 to January 2019 were selected as the subjects.According to the random number table method, the patients were divided into group Ⅰ(27 cases) and group Ⅱ(31 cases).Group Ⅰwas given intratympanic hormone injection immediately after oral administration, and group Ⅱwas given intratympanic hormone injection one week after oral administration.The auditory threshold, total effective rate and total incidence of complications were compared between the two groups.Results The auditory threshold of the two groups after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05).There was no significant difference in auditory threshold between the two groups after treatment (P＞0.05).There were no significant differences in the total effective rate and total incidence of complications between the two groups (P＞0.05).Conclusion The clinical effect of intratympanic hormone injection at different time is similar for patients with total frequency type profound sudden sensorineural hearing loss, and it can be used according to the specific situation of patients. 2020 Vol. 27 (13): 97-100 [Abstract] ( 89 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 101 Application effect comparison of stainless steel ligature wire and elastic ligation ring archwire in oral orthodontics ZHOU Yu-hui Objective To compare the application effect of stainless steel ligature wire and elastic ligature ring archwire in oral orthodontics.Methods From January 2014 to January 2019, 124 patients who received orthodontic treatment in our hospital were selected as the study objects.According to the coin tossing method, they were divided into the control group (n=62) and the observation group (n=62).Patients in the control group received elastic ligation and archwire fixation, and the patients in the observation group received stainless steel ligation.The treatment effect after 6 months of treatment, the time of orthodontic ligation and dismantling during orthodontic treatment, oral microbial environment between the two groups were compared.Results The total effective rate (96.77%) in the observation group was higher than that in the control group (77.42%), and the difference was statistically significant (P＜0.05).In the observation group, the orthodontic ligation time and removal time were longer than those in the control group, the differences were statistically significant (P＜0.05).The total detection rate of oral microbes in the observation group (9.68%) was lower than that in the control group (32.26%), and the difference was statistically significant (P＜0.05).Conclusion Compared with the elastic ligation circle archwire treatment during the oral orthodontic treatment, the stainless steel ligation wire treatment can obtain better correction effect and reduce the bacteria in the oral cavity although the ligation time and the removal time are longer. 2020 Vol. 27 (13): 101-103 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 104 Clinical effect of nasal endoscopy in the treatment of sinusitis with nasal polyps JIAO Xiao-ming Objective To explore the clinical effect of nasal endoscopy in the treatment of sinusitis with nasal polyps.Methods Eighty-eight patients with sinusitis and nasal polyps treated in our hospital from October 2017 to June 2019 were selected as the subjects.They were divided into control group (44 cases) and observation group (44 cases) according to their wishes.The patients in the control group were treated by routine operation, and the patients in the observation group were treated by nasal endoscopy.The clinical effect, operation time, intraoperative blood loss, postoperative hospital stay, visual analogue scale (VAS) score, clinical symptom scores, and complications were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 95.45%, which was higher than that in the control group (79.55%), the difference was statistically significant (P＜0.05).The operation time and postoperative hospital stay in the observation group were shorter than the control group, the intraoperative blood loss was less than that in the control group, and VAS score was lower than that in the control group, and the differences were statistically significant (P＜0.05).The scores of facial pain, olfactory disturbance, nasal obstruction, nasal secretion,dizziness and headache in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group was 4.55%, which was lower than that in the control group (18.18%), the difference was statistically significant (P＜0.05).Conclusion The treatment of nasosinusitis with nasal polyp by nasal endoscopy can effectively improve the symptoms of the nasal cavity, improve the treatment efficiency, and the surgical trauma is small, and the postoperative complications are few, so it is worth popularizing and applying. 2020 Vol. 27 (13): 104-106 [Abstract] ( 66 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 107 Application effect of Edaravone in patients undergoing thoracoscopic esophagectomy under general anesthesia TANG Yu-ru; SHUAI Xun-jun; XU Tang-wen; LI Hui; SUN Chang-rong; AI Deng-bin Objective To investigate the application effect of Edaravone in patients undergoing thoracoscopic esophagectomy under general anesthesia.Methods A total of 60 patients undergoing thoracoscopic esophagectomy under general anesthesia in Qingdao Municipal Hospital from December 2016 to August 2017 were selected as the research subjects, aged 35-68 years old, with American Society of Anesthesiologists (ASA) Ⅰ-Ⅱgrades.All patients were divided into EI group and CG group according to the random number table method, 30 cases in each group.Patients in the EI group were given intravenous infusion of Edaravone 30 mg in 0.9% sodium chloride 100 ml after induction of anesthesia, while those in the CG group were given intravenous infusion of equal amounts of sodium chloride after induction of anesthesia.The venous blood samples were obtained at the following time points respectively：before skin incision after anesthesia (T0), one lung ventilation 60 min (T1), one lung ventilation 90 min (T2), one lung ventilation 120 min (T3), dilated lung 30 min (T4) and 60 min after operation (T5), and enzyme-linked immunosorbent assay(ELISA) was used to detect phosphatidyl inositol 3-kinase (PI3K), phosphorylated protein kinase B (p-AKT), activating protein-1 (AP-1), and interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD) expression levels.The operation of the two groups of patients was compared.Results There were no significant differences in the operation time, intraoperative one lung ventilation time, anesthesia time, operation path, and post-anesthesia care unit (PACU) time between the two groups (P＞0.05).The expression levels of PI3K, p-AKT, AP-1, IL-8 and TNF-α in the plasma of the two groups at T1-T5 were higher than those at T0, and the differences were statistically significant (P＜0.05).The expression levels of SOD in the plasma of the two groups at T1-T5 were lower than those at T0, and the differences were statistically significant (P＜0.05).The expression levels of PI3K, p-AKT, AP-1, IL-8 and TNF-α in the plasma of patients in EI group at T1-T5 were lower than those in CG group, and the differences were statistically significant (P＜0.05).The expression levels of SOD in the plasma of patients in EI group at T1-T5 were higher than those in CG group, and the differences were statistically significant (P＜0.05).Conclusion Edaravone has a protective effect on one lung ventilation-induced lung injury, and reduces the postoperative pulmonary inflammatory response by reducing the release of pro-inflammatory cytokines. 2020 Vol. 27 (13): 107-110 [Abstract] ( 60 ) HTML (42 KB)  PDF  (0 KB)  ( 13 ) 111 Influence of general anesthesia or epidural anesthesia on myocardial function in patients with ischemia-reperfusion ZOU Jie-he； WU Xi-mei Objective To investigate the influence of general anesthesia or epidural anesthesia on myocardial function in patients with ischemia-reperfusion.Methods From October 2016 to October 2018, 60 patients who received abdominal surgery in our hospital and had myocardial ischemia-reperfusion injury were selected and divided into the control group and the study group according to random number table method, 30 cases in each group.General anesthesia was performed in the control group, and epidural anesthesia was performed in the study group.The effects of surgery anesthesia, changes of myocardial function related indexes before and after anesthesia, adverse reactions induced by anesthesia, recovery time of anesthesia, hospitalization time and patients′ satisfaction were compared between the two groups.Results The total effective rate of anesthesia in the study group was higher than that in the control group, the incidence of adverse reactions in the study group was lower than that in the control group, the recovery time and postoperative hospitalization time of anesthesia in the study group were shorter than that in the control group, and the satisfaction of anesthesia program and effect in the study group was higher than that in the control group, the differences were statistically significant (P＜0.05).Conclusion Patients undergoing abdominal surgery and myocardial injury due to ischemia-reperfusion received epidural anesthesia during the treatment period, which can not only improve the effect of anesthesia, but also reduce the impact on myocardial function, shorten the postoperative recovery time and hospitalization time, so as to reduce anesthesia related adverse reactions and achieve the desired effect. 2020 Vol. 27 (13): 111-113转117 [Abstract] ( 69 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 114 Effect of Dexmedetomidine combined with Pentazocine on restlessness and hemodynamics during general anesthesia recovery period in elderly patients LU You-ming Objective To investigate the effect of Dexmedetomidine combined with Pentazocine on restlessness and hemodynamics during general anesthesia recovery period in elderly patients.Methods A total of 150 elderly patients admitted to our hospital from January to December 2018 were selected as the research objects, and they were divided into group D+P (75 cases) and group P (75 cases) according to the random number table method.Patients in group D+P were anesthetized with Dexmedetomidine combined with Pentazocine, and patients in group P were anesthetized with Pentazocine.The heart rate (HR) and mean arterial blood pressure (MAP) at the completion of surgery (T1), tracheal tube extraction (T2), and 5 minutes after tracheal tube extraction (T3) were compared in the two groups, the incidence of adverse reactions in the two groups was observed,and the time of tracheal tube extraction and the first time of spontaneous respiration in the two groups of patients were recorded.Results The HR and MAP of patients in group D+P at T1-T3 were lower than those in group P, and the differences were statistically significant (P＜0.05).The HR and MAP at T2 and T3 in group D+P were higher than those at T1,and the differences were statistically significant (P＜0.05).The HR and MAP at T2 and T3 in group P were higher than those at T1, and the differences were statistically significant (P＜0.05).The incidence rates of nausea, vomiting and agitation in group D+P were lower than those in group P, and the differences were statistically significant (P＜0.05).The incidence rate of bradycardia in group D+P was higher than that in group P,and the difference was statistically significant (P＜0.05).The time of tracheal tube extraction and the first time of spontaneous respiration in group D+P were shorter than those in group P, and the differences were statistically significant(P＜0.05).Conclusion The use of Dexmedetomidine combined with Pentazocine during surgery in elderly patients has a low incidence of adverse reactions, hemodynamic stability can be guaranteed during the general anesthesia recovery period, and it can shorten the time of tracheal tube extraction and the first time of spontaneous respiration, which can be used as an important anesthesia method for elderly patients, and it is worthy of widespread application in clinic. 2020 Vol. 27 (13): 114-117 [Abstract] ( 65 ) HTML (41 KB)  PDF  (0 KB)  ( 13 ) 118 Influence of continuous epidural anesthesia on analgesic effect, labor process and maternal and infant outcome of painless delivery in parturients LONG Ting-hui Objective To explore the influence of continuous epidural anesthesia on analgesic effect, labor process and maternal and infant outcome of painless delivery in parturients.Methods A total of 500 cases of parturient patients admitted to hospital from January 2015 to April 2019 were selected as the study objects, and they were divided into group A (250 cases) and group B (250 cases) according to the random number table method.Group A did not receive labor analgesia, and group B received continuous epidural anesthesia.The analgesic effect, duration of labor process and maternal and infant outcomes of the two groups were compared.Results After intervention, the visual analogy scale (VAS)score of group B was higher than that of group A, the first and second duration of labor process in group B were shorter than that in group A, the rate of spontaneous delivery in group B was higher than that in group A, and the rate of neonatal asphyxia in group B was lower than that in group A, the differences were statistically significant (P＜0.05).Conclusion The application of continuous epidural anesthesia of painless delivery in parturients can effectively relieve the degree of labor pain, shorten the time of labor process, improve the rate of spontaneous delivery, and improve the outcome of maternal and infant.It is worthy of popularizing and application in clinical practice. 2020 Vol. 27 (13): 118-120 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 2 ) 121 Application of entropy index monitoring for general anesthesia in the elderly patients underwent abdominal surgery ZHU Yu-mei Objective To explore the application of entropy index monitoring for general anesthesia in the elderly patients underwent abdominal surgery.Methods A total of 60 elderly patients underwent elective abdominal surgery under general anesthesia who were admitted to our hospital from February 2018 to October 2019 were selected as the research objects,and they were divided into group E(n=30)and Group C(n=30)according to random number table method.Group E adjusted Remifentanil and Sevoflurane according to entropy index, group C adjusted Remifentanil and Sevoflurane according to blood pressure and heart rate (HR).The systolic blood pressure (SBP), diastolic blood pressure(DBP), HR at the time before anesthesia (T0), before induction (T1), after induction (T2), during skin incision (T3), after extubation (T4), the dosage of Remifentanil, the average inhalation concentration of Sevoflurane, the time of spontaneous breathing, eye opening, extubation, satisfaction scores , adverse reaction were compared between the two groups.Results The SBP, DBP and HR of group E at T1 were lower than those at T0, the differences were statistically significant(P＜0.05).The SBP, DBP and HR in group C at T1 were lower than at T0, the SBP, DBP and HR in group C at T3 and T4 were higher than those at T0, the differences were statistically significant (P＜0.05).The SBP, DBP and HR of group E at T1 were higher than those of group C, the SBP, DBP and HR of group E at T3 and T4 were lower than those of group C, the differences were statistically significant (P＜0.05).There were no significant differences in SBP, DBP, HR between T2, T3, T4 and T0 in group E (P＞0.05).There were no significant differences in SBP, DBP, HR between T0 and T2 in group C (P＞0.05).There were no significant differences in SBP, DBP and HR between the two groups at T2 (P＞0.05).The time of respiratory recovery, eye opening and extubation in Group E were shorter than those in group C, the dosage of anesthetics in Group E was less than that in group C, and the satisfaction rate in Group E was higher than that in group C, the differences were statistically significant (P＜0.05).The incidence rates of nausea, hypotension, restlessness and cognitive impairment in Group E were lower than those in group C, the differences were statistically significant (P＜0.05).There were no significant differences in the incidence of vomiting, intraoperative awareness, bradycardia and respiratory depression between the two groups (P＞0.05).The total incidence of adverse reactions in Group E was lower than that in group C, the difference was statistically significant (P＜0.05).Conclusion Application of entropy index monitoring in the elderly patients underwent abdominal surgery with general anesthesia can improve the anesthesia quality and save the anesthesia cost. 2020 Vol. 27 (13): 121-124 [Abstract] ( 57 ) HTML (46 KB)  PDF  (0 KB)  ( 8 ) 125 Comparison of diagnostic value of electrocardiogram and echocardiography in hypertensive heart disease WEN Cui; WANG Dan-yu Objective To compare the diagnostic value of electrocardiogram and echocardiography in hypertensive heart disease.Methods A total of 160 suspected patients with hypertensive heart disease who were admitted to our hospital from October 2017 to October 2018 were selected as research objects.All patients were examined by electrocardiogram and echocardiography.The sensitivity, specificity, positive rate and detection accuracy of the two methods were compared.Results Among 160 suspected patients with hypertensive heart disease, 45 cases were negative and 115 cases were positive that were confirmed by "gold standard", of which 82 cases were positive and 78 cases were negative that were inspected by electrocardiogram, 95 cases were positive and 65 cases were negative that were inspected by echocardiography.The sensitivity, specificity and accuracy of echocardiography were higher than those of electrocardiogram, the differences were statistically significant (P＜0.05).Conclusion Echocardiography has high sensitivity, specificity and accuracy in the diagnosis of hypertensive heart disease, which has high diagnostic value and is worth popularizing and application. 2020 Vol. 27 (13): 125-127 [Abstract] ( 75 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 128 Diagnostic value of SPECT/CT tomographic fusion imaging in bone metastasis of prostate cancer LIAN Li-tao Objective To investigate the diagnostic value of SPECT/CT tomographic fusion imaging in the bone metastasis of prostate cancer.Methods A total of 110 patients with suspected prostate cancer admitted to People′s Hospital of Nanshan District of Shenzhen City from March 2017 to July 2019 were selected as the research objects.All patients received 99mTc-MDP intravenous injection, and all patients were examined by single photon emission computed tomography (SPECT) and SPECT/CT.Pathological examination was the "gold standard" for the diagnosis of the disease.The sensitivity, specificity and accuracy of SPECT/CT fusion images and SPECT whole body bone scan were compared.Results The sensitivity and accuracy of SPECT/CT tomography were higher than those of SPECT whole body bone scan,and the differences were statistically significant (P＜0.05).There was no significant difference in the specificity of the two examination methods(P＞0.05).Conclusion The diagnostic value of SPECT/CT tomographic fusion imaging in the bone metastasis of prostate cancer is significant, and high diagnostic sensitivity, specificity and accuracy can be obtained. 2020 Vol. 27 (13): 128-130 [Abstract] ( 67 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 131 Application value of digital radiography photography technology in health examination of inorganic dust operators in Jiangmen City LING Cai-hong Objective To explore the application value of digital radiography (DR) technology in health examination of inorganic dust operators in Jiangmen City.Methods Forty-one inorganic dust operators in Jiangmen City who had health examination in our hospital from January to June 2018 were selected as the research objects, and they were examined by both traditional high-KV photography and DR photography.The chest image quality and pneumoconiosis detection rate of the two methods were compared.Results After comparison, the photography quality of DR on chest was better than that of traditional high-KV chest radiograph, and the difference was statistically significant (P＜0.05).The rate of excellent images using DR on chest was higher than that of the traditional high-KV chest radiograph, and the difference was statistically significant (P＜0.05).The pneumoconiosis detection rate of DR chest radiograph was higher than that of traditional high-KV chest radiograph, with statistical significance (P＜0.05).The pneumoconiosis grade determined based on DR chest radiography was better than that of traditional high-KV chest radiograph, and the difference was statistically significant (P＜0.05).Conclusion The chest radiograph of DR can be used for health examination of dust operators, and has good clinical value. 2020 Vol. 27 (13): 131-133 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 134 Application value of ultrasonography in the diagnosis of liver fibrosis in patients with viral hepatitis XIE Xiao-qin Objective To explore the application value of ultrasonography in the diagnosis of liver fibrosis in patients with viral hepatitis.Methods A total of 50 patients with viral hepatitis admitted to our hospital from January 2018 to January 2019 were selected as the research objects, and were divided into 5 stages according to the results of puncture biopsies：no liver fibrosis to liver cirrhosis (S0-S4).The biopsies were divided into 4 grades (G1-G4) according to inflammation.The differences in the ultrasound indicators (maximum velocity of portal vein, thickness of gallbladder wall,long diameter of spleen and inner diameter of portal vein trunk) were compared.Results In the whole ultrasonic qualitative index structure, the distribution and morphology of light spots in liver parenchyma were abnormal, and the echo of liver surface was related to the grade of inflammation.However, in view of these qualitative indexes, there was a great variation in the diagnosis and judgment of specific patients.Among the degree of liver fibrosis, there were differences in the diameter of spleen portal vein and the length of spleen (P＜0.05).The limit value of the spleen′s long diameter was 12.1 cm, and the specificity and sensitivity for the diagnosis of early cirrhosis were 75.2% and 60.0%, respectively.Taking the splenic vein inner diameter of 8 mm as the limit value, the specificity and sensitivity for the diagnosis of early cirrhosis were 78.0% and 60.0% respectively.When the limit value of inner diameter of portal vein trunk was 12 mm, the specificity and sensitivity in the diagnosis of early liver cirrhosis were 44.5% and 76.6%.If the limit value of maximum velocity of portal vein was 30.5 cm/s, the specificity and sensitivity for the diagnosis of early liver cirrhosis were 66.8% and 78.5%, respectively.Conclusion Ultrasonography is practical and efficient in the diagnosis of liver fibrosis in viral hepatitis, with outstanding clinical application value. 2020 Vol. 27 (13): 134-136 [Abstract] ( 56 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 137 Clinical effect of Feitai Capsules combined with Western antituberculosis drug in the treatment of preliminary smear-positive pulmonary tuberculosis WU Xian-hui; YI Shu-lin Objective To investigate the effect and safety of Feitai Capsules combined with Western antituberculosis drug in the treatment of preliminary smear-positive pulmonary tuberculosis.Methods From January 2016 to December 2018, 150 patients with newly diagnosed smear-positive pulmonary tuberculosis who were treated in the Yingtan People′s Hospital (Railway Branch) were selected as the research subjects.The patients were randomly divided into the control group (n=75) and study group (n=75) using computer-generated random number.In the control group, 2HRZE/4HR regimen was used, while in the study group, Feitai Capsules on the basis of the control group were added.The clinical efficacy of the two groups was compared.The sputum negative conversion rate of the two groups was compared.The lung lesion absorption, cavity closure and clinical symptom improvement were compared between the two groups.The total incidence of adverse reactions was compared between the two groups.Results The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05).The sputum negative conversion rate in the study group was higher than that in the control group at the end of 2, 5, and 6 months treatment,the differences were statistically significant(P＜0.05).After treatment,the lung lesion absorption rate,cavity closure rate, and clinical symptom improvement rate in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The lesion absorption time, cavity closure time and clinical symptom improvement time of patients in the study group were all shorter than those in the control group, with statistically significant differences (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Feitai Capsules combined with Western antituberculosis drug for the treatment of smear-positive pulmonary tuberculosis are effective and safe.Feitai Capsules can be used as an adjuvant treatment for preliminary smear-positive tuberculosis. 2020 Vol. 27 (13): 137-140 [Abstract] ( 73 ) HTML (38 KB)  PDF  (0 KB)  ( 14 ) 141 Clinical effect comparison of Methimazole and Propylthiouracil in the treatment of thyroid glands syndrome WANG Ming Objective To compare the clinical application effect of Methimazole and Propylthiouracil in the treatment of thyroid glands syndrome (hereinafter referred to as hyperthyroidism).Methods A total of 114 patients with hyperthyroidism admitted to our hospital from January 2018 to June 2019 were selected as the study subjects.The patients were divided into normal group (57 cases) and scientific research group (57 cases) by random number table method.The patients in normal group were treated with Propylthiouracil.The patients in the scientific research group were treated with Methimazole.The thyroid hormone levels at different time stages (before treatment, 60 and 90 days after treatment), the total incidence of adverse reactions, the treatment time, the length of stay and the time of symptom improvement were compared between the two groups.Results After 60 and 90 days of treatment, the levels of free triiodothyronine (FT3)and free thyroxine (FT4) in the scientific research group were lower than those in the normal group, with statistically significant differences (P＜0.05).The levels of thyroid-stimulating hormone (TSH) in the scientific research group after 60 and 90 days of treatment were higher than those in the normal group, and the differences were statistically significant (P＜0.05).The overall incidence of adverse reactions in the scientific research group was lower than that in the normal group, and the difference between the two groups was statistically significant (P＜0.05).There was no significant difference in treatment time between the two groups (P＞0.05).The length of stay and symptom improvement time of patients in the scientific research group were shorter than those in the normal group, and the differences were statistically significant (P＜0.05).Conclusion After comparing the clinical effect and safety of Methimazole with that of Propylthiouracil in the treatment of hyperthyroidism, the safety of Methimazole is higher and the incidence of adverse reactions can be reduced obviously.But in the actual treatment process should still be combined with the patient′s condition to choose different drugs, its blood routine, liver function changes for careful observation. 2020 Vol. 27 (13): 141-144 [Abstract] ( 77 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 145 Application effect of early adequate Valaciclovir combined with Glucocorticoid and Valaciclovir alone in the treatment of middle-aged and elderly patients with herpes zoster ZHANG Lin Objective To explore the effect and safety of Valaciclovir alone and early adequate Valaciclovir combined with Glucocorticoid in the treatment of middle-aged and elderly patients with herpes zoster.Methods Seventy-five middle-aged and elderly patients with herpes zoster who were treated in our hospital from October 2018 to September 2019 were selected as subjects.They were divided into the single group (37 patients) and the combination group (38 patients) by alternating grouping method, the single group was treated with Valacyclovir, and the combination group was treated with early adequate Valaciclovir combined with Glucocorticoid.The pain disappearance time, stagnation time,scarring time, total effective rate of treatment and total incidence of adverse reactions were compared between the two groups.Results The pain disappearance time, stagnation time and scarring time in the combination group were shorter than those in the single group, and the differences were statistically significant (P＜0.05).The total effective rate of treatment in the combination group (97.74%) was higher than that in the single group (72.97%), the total incidence of adverse reactions in the combination group (2.63%) was lower than that in the single group (18.92%), the differences between the two groups were statistically significant (P＜0.05).Conclusion The combination of Glucocorticoid and early adequate Valaciclovir in the treatment of middle-aged and elderly patients with herpes zoster has better effect, can effectively improve the clinical symptoms, reduce the incidence of adverse reactions, and has better safety, which is worthy of clinical promotion. 2020 Vol. 27 (13): 145-147 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 148 Experience of lung cancer treated by professor Ma Ke MA Lu； MA Ke； XIA Shu-min； DU Hai-xia Professor Ma Ke has been engaged in clinical and scientific research in cancer for more than 20 years, who has his own insights into the treatment of lung cancer, especially applying traditional Chinese herbal medicine in pairs to treat various patterns of lung cancer and has achieved favorable effect.In this article, professor Ma Ke′s experience in the treatment of lung cancer using traditional Chinese herbal medicines in pairs was introduced.The basic idea of professor Ma Ke′s clinical treatment of lung cancer is to give basic herbal pairs based on the early stage of pattern identification, and then considering the lesions of the affected organs to construct a formula targeting on certain patterns,and in the later stage, focusing on the changes of the patients′ condition to modify the prepared formula in order to restore the function viscera internal organs of patients.The characteristics of the herbal pairs are based on the meridian entry, reasonable dose compatibility, the overall consideration of the patients′ cancer conditions and its etiology and pathogenesis.After in-depth study of the herbal compatibility and long-term clinical practice, professor Ma Ke has developed its own ideas.The formulation is unique and the effect is remarkable, thus summing to share with peer. 2020 Vol. 27 (13): 148-150转157 [Abstract] ( 90 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 151 Treatment of senile functional constipation from the holism of five Zang organs LIANG Li-jie； HE Feng-hua； LIU Yu-zi； WU Ye； XIE Ze-hong； HONG An-jing； LI Shu Traditional Chinese medicine has obvious advantages in the treatment of functional constipation, which can not only relieve constipation, adjust the disordered gastrointestinal function, but also improve the physical condition of patients.But at present, there are many disadvantages in the treatment of functional constipation in the elderly according to traditional Chinese medicine, such as confusion of clinical syndrome types, various names, no unified standard and so on.It is caused by the imbalance of Qi, Blood, Yin and Yang in human body, and it is also the local manifestation of the imbalance of multiple viscera functions in the intestine.Although the disease is located in the large intestine, the cause of the disease is closely related to the dysfunction of the spleen, kidney, lung, heart and liver.Based on the clinical experience and literature research, this paper analyzes the elderly functional constipation from holism of five Zang organs, and discusses the relationship between the five Zang organs and constipation.The treatment is based on the spleen, kidney, lung, heart and liver, respectively, with the principle of “syndrome differentiation and treatment”, prescriptions based on the five Zang organs, and guided treatment of senile functional constipation by the maintenance of the normal function of the five Zang organs. 2020 Vol. 27 (13): 151-153 [Abstract] ( 60 ) HTML (37 KB)  PDF  (0 KB)  ( 11 ) 154 Comparison of Yiqi Huoxue Decoction and Fracture Detumescence Decoction in preventing deep venous thrombosis in lower limbs after hip fracture in the elderly BI Fang-shan； YIN Tian； LIU Yang； NIU Kai； HOU Yun-jie； CHEN Wen-xue； ZHAO Xing-wei Objective To explore the effect of Yiqi Huoxue Decoction and Fracture Detumescence Decoction in preventing deep venous thrombosis in lower limbs after hip fracture in the elderly.Methods Sixty elderly hip fracture patients who underwent hip replacement surgery in our hospital from January 2017 to October 2018 were selected as the research subjects and divided into experimental group (30 cases) and control group (30 cases) according to random number table method.The control group was treated with Fracture Detumescence Decoction after operation, and the experimental group was treated with Yiqi Huoxue Decoction after operation.The incidence of deep venous thrombosis of the lower limbs, incidence of adverse reactions, plasma prothrombin time, fibrinogen, activated partial thrombin time,D-dimer levels were compared.Results The incidence of lower limbs deep venous thrombosis in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05); the total incidence of adverse reactions in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05); The plasma prothrombin time and activated partial thrombin time were longer in the experimental group than in the control group, and the levels of fibrinogen and D-dimer were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion Elderly hip fracture surgery patients receiving Yiqi Huoxue Decoction can promote blood circulation and reduce the incidence of deep venous thrombosis of lower limbs, and have fewer adverse reactions, which is worthy of promotion and application. 2020 Vol. 27 (13): 154-157 [Abstract] ( 62 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 158 One case of professor You Zhao-ling in the treatment of infertility due to intrauterine adhesions TANG Li; TAN Zhen-Yu; YOU Zhao-Ling; QIU Le-Le Uterine adhesion is a kind of damaging lesion of the endometrium, which is a pathological phenomenon that the basal layer of the endometrium is damaged by various reasons and the uterine walls adhere to each other.Professor You Zhao-ling believes that intrauterine adhesion is in the category of "hypomenorrhea" "amenorrhea" and "infertility"of traditional Chinese Medicine according to the manifestations, the syndrome differentiation is mainly based on kidney deficiency and blood stasis syndrome, and the combination of traditional Chinese medicine and Western medicine has obvious clinical effect.In the process of diagnosis and treatment of the disease, professor You comprehensively and accurately analyzes its occurrence, development and prognosis, gives appropriate suggestion and treatment, and brings hope to the help seeker, whose ideas of diagnosis and treatment and sincerities of medicine are worth studying.This article introduces one case of professor You Zhao-ling in the treatment of infertility due to intrauterine adhesions, analyzes ideas of diagnosis and treatment to benefit the peer. 2020 Vol. 27 (13): 158-161 [Abstract] ( 61 ) HTML (40 KB)  PDF  (0 KB)  ( 6 ) 162 Construction and development of bio-pharmaceutical major at Beijing University of Chinese Medicine XU Wen-juan; ZHANG Jian; HE Ping ; LIU Ying It is very important to train talents for the development of biological technology industry in China.Beijing University of Chinese Medicine set up the major of bio-pharmaceutical depending on the National Base of Life Science and Technology Education in 2003.Based on the educational philosophy of combination of traditional Chinese medicine and modern life science, fifteen years of undergraduates have been trained.According to the training process of the bio-pharmaceutical major, this paper discussed the training objective, requirements, courses, and teacher construction,and analyzed the future of this major and students′ career choices.We hope this paper will provide a reference for constructing the same major for other traditional Chinese medicine universities. 2020 Vol. 27 (13): 162-165 [Abstract] ( 73 ) HTML (39 KB)  PDF  (0 KB)  ( 14 ) 166 Analysis of independent risk factors of hypertensive patients among native Tibetan GUAN Hong-yin; TIAN Peng; CHEN Yan; Yangla; GAO Fei-fei; ZHAXI Luo-bu; AWANG Duo-ji; Deji Objective To analyze the independent risk factors of hypertensive in native Tibetan.Methods A total of 111 cases of hypertension admitted to our hospital from May 2018 to December 2018 were selected as the case group.Altogether 236 non-hypertensive patients were selected as the control group.The clinical data of the two groups were compared, and the risk factors of hypertension were analyzed by Logistic regression analysis.Results There were significant differences in age, blood pressure, occupation, educational level and drinking between two groups (P＜0.05).Logistic multivariate analysis showed that age (β=0.050, OR=1.051, 95%CI：[1.008～1.096]), systolic blood pressure (β=0.100,OR=1.105, 95%CI：[1.071～1.140]), diastolic blood pressure (β=0.061, OR=1.063, 95%CI：[1.012～1.116]) were risk factor for hypertension (P＜0.05).Conclusion Native Tibetan hypertensive patients need to actively reduce blood pressure,especially in older patients, they need to know their blood pressure values in real time and adjust blood pressure values in time. 2020 Vol. 27 (13): 166-169 [Abstract] ( 74 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 170 Investigation analysis of prescription reviews in our community service station OU Huan-jiao； HU Hui-qin； CHEN Jia-zhi； ZENG Hui-fen； SHEN Li Objective To randomly check out community outpatient prescriptions and give comments, and analyze the unreasonable drug use of the prescriptions, so as to promote the rational use of drugs by medical staff at the primary level.Methods From June 2017 to June 2019, prescriptions from eight community service stations affiliated to our hospital were randomly selected and reviewed.A total of 3600 prescriptions were collected and the reviews were analyzed statistically.Results A total of 3567 prescriptions were commented and analyzed.The use of antibacterial drugs was 21.75%, the use of glucocorticoids accounted for 11.44%.The incidence rate of unreasonable prescriptions was 7.06%.Inappropriate dosage forms and administration routes were the most common, followed by medication without indication, inappropriate selection of drugs, and unsuitable usage and dosage.Conclusion The community service station should take prescription reviews as the cornerstone.Clinical pharmacists together with the community health service office routinely conduct prescription reviews and give the feedback after the reviews to doctors in order to enhance the awareness of safe medication in doctors at primary level and promote rational clinical use of drug. 2020 Vol. 27 (13): 170-172转176 [Abstract] ( 65 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 173 Investigation and analysis of antiplatelet drugs used in elderly outpatients with coronary heart disease in our hospital FANG Hai-yan； CHEN Li-xin Objective To investigate the use of antiplatelet drugs in elderly outpatients with coronary heart disease in our hospital.Methods Altogether 100 prescriptions were randomly extracted from elderly outpatients with coronary heart disease every month from January to December 2018 and a total of 1200 prescriptions were selected for investigation analysis.Then the use of antiplatelet drugs was counted and analyzed.Results The percentage of the use of Aluminum Magnesium Aspirin, Aspirin, Clopidogrel and Ticagrelor was 5.67%, 53.67%, 23.67% and 0.67%, respectively.Among them, antiplatelet drugs were used in 848 prescriptions (70.67%), including 148 prescriptions (12.33%) for two antiplatelet drugs used and 700 prescriptions (58.33%) for one antiplatelet drug used.The most frequently prescribed antiplatelet drugs were Aspirin and Clopidogrel.Meanwhile, 12 unreasonable prescriptions (1.00%) were found in this study and all the unreasonable prescriptions were accounted for adverse drug interactions between Clopidogrel and proton pump inhibitors.Conclusion The proportion of antiplatelet drugs used in elderly outpatients with coronary heart disease in our hospital is relatively high and the traditional antiplatelet drug (Aspirin) is still the main used drug.The use of antiplatelet drugs is basically reasonable, but more attention to drug interactions between Clopidogrel and proton pump inhibitors should be paid. 2020 Vol. 27 (13): 173-176 [Abstract] ( 63 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 177 Analysis of the first hepatitis B vaccine vaccination for the neonates of Yizhou District in Hechi City from 2015 to 2018 HUANG Huan-hui； WEI Ri-jiang Objective To analyze the first hepatitis B vaccine vaccination for the neonates of Yizhou District in Hechi City from 2015 to 2018.Methods Based on the information management platform of vaccination in Guangxi Zhuang Autonomous Region, the information of the first dose of hepatitis B vaccination for the neonates of Yizhou District in Hechi City from 2015 to 2018 was derived.The first dose of hepatitis B vaccine vaccination in different years, the first dose of hepatitis B vaccine vaccination in different medical institutions and the reasons for not timely vaccination were analyzed.Results In 2015-2018, 29 457 neonates were delivered to four hospitals of Yizhou District in Hechi City,96.62% of whom received the first hepatitis B vaccine, and 94.88% of them received it in time.In 2017, the rate of hepatitis B vaccine and the rate of hepatitis B vaccine in time were higher.The vaccination rate and the timely rate of hepatitis B vaccine was the highest in Hospital of traditional Chinese medicine of Yizhou District of Hechi City, which was the lowest in People′s Hospital of Yizhou District of Hechi City.Low birth weight (43.20%), premature birth and dystocia (29.13%) were the main reasons why the first hepatitis B vaccine was not given in time.The most children in the People′s Hospital of Yizhou District of Hechi City were not in time, accounting for 73.13%.Conclusion The timely rate of the first hepatitis B vaccine vaccination has reached a high level in Yizhou District of Hechi City.It is necessary to strengthen the training so that the vaccinators can correctly grasp the contraindications of hepatitis B vaccination, strengthen health education and further improve the timely rate of the first hepatitis B vaccine vaccination. 2020 Vol. 27 (13): 177-179 [Abstract] ( 79 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 180 Analysis of infection status of Group B Streptococcus and pregnancy outcomes in perinatal pregnant women in a tertiary hospital in Nanchang City ZHA Gu-zhang； YUAN Li Objective To analyze the infection status of Group B Streptococci (GBS) in perinatal women in a tertiary hospital in Nanchang City and its effect on pregnancy outcome.Methods From April 2018 to March 2019, a total of 1137 perinatal pregnant women who came to the hospital to perform prenatal examination and have a delivery were selected as the research object.The anus and genital tract secretions were taken for bacterial culture, according to the culture results, they were divided into the infection group and the control group, and the status of infection and its relevant factors were analyzed.In addition, the incidence of adverse pregnancy outcomes was compared between the two groups.Results A total of 67 cases of GBS were detected in the 1137 cases of perinatal pregnant women, the infection rate was 5.89%(67/1137);as for puerperal who ≥35 years old,≥3 times of abortion history,undergraduate and above,the infection rates were 9.63%,11.43%,7.01%respectively,which were higher than the infection rates of puerperal ＜35 years old, ＜3 times of abortion history, bachelor degree or below, which were 4.55%, 5.33%, 3.54%.The differences were statistically significant (P＜0.05).The incidence rates of puerperal infection, premature rupture of membranes, premature delivery in infection group were 16.42%, 10.45% and 13.43% respectively, which were higher than 7.20%, 5.40% and 6.36% of the control group.The differences were statistically significant (P＜0.05).The incidence rates of neonatal upper respiratory tract infection, pathological jaundice , neonatal low weight in infection group were 5.97%, 28.36% and 7.46% respectively, which were higher than 1.03%, 10.75%, 1.96% of the control group.The differences were statistically significant (P＜0.05).There were no significant differences in the incident rates of dystocia and neonatal asphyxia in the two groups.(P＞0.05).Conclusion The incidence of GBS among pregnant women in the perinatal period is higher in the hospital, which is related to the age, abortion history and educational background of pregnant women.GBS infection can lead to maternal puerperal infection, premature rupture of membranes and premature delivery, and increase the incidence of neonatal upper respiratory tract infection, pathological jaundice and low neonatal weight, which seriously affects maternal and infant health. 2020 Vol. 27 (13): 180-182 [Abstract] ( 64 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 183 Clinical practice of multi -disciplinary structured three -level nursing rounds LIN Qiu-wei； CHEN Yu-fang； SONG Hai-ping Objective To establish a multi-disciplinary structured three-level nursing rounds model and explore its clinical value.Methods A total of 10 clinical nursing units of our hospital from September 2018 to August 2019 were randomly divided into the control group and the observation group by cluster sampling method, each with 5 units.There were 82 nurses in the control group and 86 nurses in the observation group.The traditional three-level nursing rounds were used in the control group, and the multi-disciplinary structured three-level nursing rounds were used in the observation group.The ability of critical thinking, the level of specialized knowledge and the satisfaction of nursing service of the two groups were compared.Results Before the intervention, there were no significant differences between the two groups in the scores of critical thinking ability and specialized knowledge theory (P＞0.05).After intervention,the scores of critical thinking ability and specialized knowledge theory in the observation group were higher than before riter uention and that in the control group, and the patients′ satisfaction of nursing service was higher than that in the control group, and the differences were statistically significant (P＜0.05).Conclusion The multi-disciplinary structured three-level nursing rounds can improve the critical thinking ability and professional knowledge level of nurses, improve the quality of nursing services, and improve the satisfaction of patients with nursing services. 2020 Vol. 27 (13): 183-185转199 [Abstract] ( 67 ) HTML (35 KB)  PDF  (0 KB)  ( 3 ) 186 Effect of nursing quality management on hospital infection control rate,nursing-patient disputes and nursing quality of hospitalized patients in neurosurgery OU Yong-zhen； LIANG Xing-ling ； YE Jian-hui Objective To explore the effect of nursing quality management on hospital infection control rate, nursingpatient disputes and nursing quality of hospitalized patients in neurosurgery.Methods Sixty inpatients undergoing neurosurgery in our hospital from May 2017 to May 2019 were selected as the research subjects, and were divided into the control group (n=30) and the observation group (n=30) according to the random number table method.In the control group, routine nursing intervention was used, and in the observation group, nursing quality management was adopted.The hospital infection control rate, nurse-patient dispute rate, and nursing quality score were compared between the two groups.Results The rate of hospital infection control in the observation group was 6.67%, lower than that of the control group accounting for 26.67% (P＜0.05).The incidence of nursing disputes (0.00%) in the observation group was lower than that in the control group (13.33%) (P＜0.05).Nursing quality score in the observation group was higher than that in the control group (P＜0.05).Conclusion Nursing quality management for inpatients can effectively reduce the incidence of hospital infection and nurse-patient disputes, and can also improve the nursing quality.Therefore, this management pattern is worth promoting in the clinic. 2020 Vol. 27 (13): 186-188 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 189 Application effect of postoperative pain management by multidisciplinary team in total hip replacement for 72 hours ZHOU Lan-dao； WANG Qiao-na； YANG Meng； HUANG Qiu-huan Objective To investigate the effect of multidisciplinary team on postoperative pain management in total hip arthroplasty (THA) for 72 hours.Methods From February to July 2016, 92 patients who underwent THA in our hospital were selected and divided into observation group and control group on the longitudinal axis of time.The control group used routine pain management after hip replacement, while the observation group was combined with multidisciplinary,the incidence of moderate and severe pain and the efficiency of pain management between the two groups within 72 h after operation were compared.Results The incidence of moderate and severe activity pain in the observation group within 72 h after operation was lower than that in the control group, the effective rates of pain management was higher than that of the control group, and the differences were statistically significant (P＜0.05).Conclusion Multidisciplinary diagnosis and treatment teams, can effectively reduce the pain intensity after THA for 72 h and improve the pain management effect after THA. 2020 Vol. 27 (13): 189-192 [Abstract] ( 63 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 193 Application value of predictive nursing in preventing pulmonary infection in patients undergoing tracheotomy in neurosurgical intensive care unit YUAN Na Objective To explore the clinical application value of predictive nursing in preventing pulmonary infection in patients undergoing tracheotomy in neurosurgical intensive care unit (NICU).Methods A total of 90 patients with tracheotomy and pulmonary who were admitted to our hospital from June 2015 and June 2019 were selected as the subjects.They were divided into the observation group (n=45) and the control group (n=45) by random number table method.The control group was given routine nursing, while the observation group was given both routine nursing and predictive nursing.The situation of pulmonary infection, effects of anti-infective treatment, total incidence of adverse reactions and satisfaction were compared between the two groups.Results The incidence rate of pulmonary infection and the total incidence rate of adverse reactions in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The effective rate of anti-infective therapy and satisfaction scores of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).Conclusion The clinical effect of predictive nursing is good in patients undergoing tracheotomy in NICU.It can effectively reduce pulmonary infection, improve the effective rate of anti-infective treatment, reduce the incidence of adverse reactions, and improve the satisfaction of patients and their family members.It is worthy of clinical use. 2020 Vol. 27 (13): 193-195 [Abstract] ( 56 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 196 Application of continuous intensive meticulous nursing in patients with severe preeclampsia ZHANG Wan-ling; LIU Qun-yan; FENG Yuan-yan Objective To explore the effect of continuous meticulous nursing in patients with severe preeclampsia.Methods Eighty patients with severe preeclampsia treated in our hospital from January to August 2019 were selected as the research objects.They were divided into the control group (n=40) and the observation group (n=40) according to the random number table method.The control group was used routine nursing, the observation group adopted continuous meticulous nursing.Pregnancy outcomes, blood pressure levels, and nursing satisfaction were compared between the two groups, and the self-rating anxiety scale (SAS) and self-depression rating scale (SDS) were used to assess the mental status of the two groups.Results The total incidence of maternal and infant complications in the observation group was lower than that in the control group, and the differences were statistically significant (P＜0.05).The systolic blood pressure and diastolic blood pressure after the intervention in the two groups were lower than before the intervention,and the differences were statistically significant (P＜0.05).Systolic and diastolic blood pressure were lower than those of the control group, and the difference was statistically significant (P＜0.05).The SAS and SDS scores of the two groups after intervention were lower than those before the intervention, the differences were statistically significant (P＜0.05).The SAS and SDS of the observation group after the intervention were lower than those of the control group, and the differences were statistically significant (P＜0.05).The overall nursing satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Continuous and detailed nursing for patients with severe pre-eclampsia can reduce the incidence of maternal and infant complications,and help alleviate patients′ negative emotions, control blood pressure levels, and improve nursing satisfaction, which has good application value. 2020 Vol. 27 (13): 196-199 [Abstract] ( 62 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 200 Effect of layered chain nursing mode on postoperative urination and defecation in patients with hemorrhoid surgery XIAO Xiao-fang; Hu Bo; ZOU Xiao-yan; XIA Lian-xiang ; YANG Hui-ping Objective To investigate the effect of layer-chain nursing mode on postoperative urination and defecation in patients with hemorrhoid surgery.Methods A total of 56 patients with hemorrhoid surgery admitted to our hospital from May 2018 to September 2019 were enrolled in the study.They were divided into reference group (n=28) and test group (n=28)according to randomized method.The reference group used traditional nursing.The urination,defecation,incidence of adverse reactions and total satisfication were compared between the two groups.Results The time of first urination，first defecation and time consumption of defecation in the test group was shorter than that in the reference group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the test group was lower than that in the reference group, and the difference was statistically significant (P＜0.05).The total satisfaction of the test group was higher than that of the reference group, and the difference was statistically significant (P＜0.05).Conclusion In patients with hemorrhoid surgery, the management of layer-chain nursing mode can not only improve postoperative urination and defecation, but also reduce postoperative adverse reactions and enhance patient satisfaction. 2020 Vol. 27 (13): 200-202 [Abstract] ( 61 ) HTML (31 KB)  PDF  (0 KB)  ( 15 ) 203 Effect of Wechat continuity nursing on self-care ability and quality of life in patients with chronic heart failure WANG Si-hua ; YANG Zhuan-qing Objective To investigate the effect of Wechat continuity nursing on self-care ability and quality of life in patients with chronic heart failure (CHF).Methods A total of 94 patients with CHF admitted to our hospital from January 2018 to June 2019 were enrolled in the study.They were divided into the control group (n=47) and the observation group (n=47) according to the random number table method.The control group received routine CHF out of hospital nursing, the observation group used Wechat-based continuity nursing.The self-care index, quality of life,medication adherence, and satisfaction of the two groups were compared between the two groups.Results After intervention, the self-care index and quality of life score of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05).The medication compliance of the observation group was higher than that of the control group (93.62% vs.78.72%), the difference was statistically significant (P＜0.05).The nursing total satisfaction of the observation group was higher than that of the control group (91.49% vs.74.47%), and the difference was statistically significant (P＜0.05).Conclusion In patients with CHF, the use of continuous nursing based on the Wechat platform can significantly improve the patient′s self-care ability and quality of life, improve the patient′s medication compliance, and improve the satisfaction of nursing services, which is worthy of clinical promotion. 2020 Vol. 27 (13): 203-205 [Abstract] ( 54 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 206 Application effect of camellia oil in oral nursing of patients with coma CHEN Dan; CAO Xiao-shan; XU Wen-min Objective To discuss the application effect of camellia oil in oral nursing of patients with coma.Methods The clinical information of 80 patients with coma treated in our hospital from February 2016 to September 2019 were analyzed.The patients were divided into the control group (n=40) and the observation group (n=40) by the random paper method.The care using sterile normal saline was given to the control group, and the care using camellia oil was given to the observation group.The evaluations of the oral mucosa, the fungal culture of throat swabs and the care effect before and after care in the two groups were observed.Results There were no statistically significant differences in positive percentages of the oral malodor, the redness and swelling or congestion of oral mucosa, the white attachment on oral mucosa, or the fungal culture of the white attachment before care between the two groups (P＞0.05).There were no statistically significant differences in the percentage of redness and swelling or congestion of oral mucosa after care between the two groups (P＞0.05).The positive percentages of the oral malodor, the white attachment on oral mucosa, or the fungal culture of the white attachment in the two groups after care were lower than those before care, the positive percentages of the oral malodor, the white attachment on oral mucosa, or the fungal culture of the white attachment in the observation group were lower than those in the control group, the overall response rate after clinical care in the observation group was higher than that in the control group, with statistical differences (P＜0.05).Conclusion The application of camellia oil in oral nursing of patients with coma can improve the oral environment and reduce the incidence of oral infection, which is worthy of popularization and application in clinical practice. 2020 Vol. 27 (13): 206-208 [Abstract] ( 50 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 209 Effect of guiding patient self-health care model in patients with chronic obstructive pulmonary disease WANG Shui-ping Objective To observe the effect of guiding patient self-health care for patients with chronic obstructive pulmonary disease (COPD).Methods Sixty patients with COPD admitted to our hospital from June 2017 to June 2018 were selected.They were divided into observation group (n=30) and control group (n=30) according to the sampling method.The observation group used the guiding patient self-health care model, while the control group used the routine nursing model, the total effective rate and lung function indicators of the two groups (the forced expiratory volume in one second [FEV1]accounted for the predicted percentage, FEV1/the forced vital capacity [FVC], FEV1) situation were compared between two groups.Results The total effective rate of the observation group was 93.33%, higher than that of the control group (73.33%), and the difference was statistically significant (P＜0.05).Before the nursing, the lung function indexes (FEV1 accounted for the predicted percentage, FEV1/FVC, FEV1) were not significantly different (P＞0.05).After nursing, the two groups of FEV1 acconted for the predicted percentage, FEV1/FVC and FEV1 were higer that those before nuring, the differences were statistically significant (P＜0.05), and the FEV1 acconted for the predicted percentage, FEV1/FVC and FEV1 were higher than the control group.The differences were statistically significant (P＜0.05).Conclusion The implementation of guiding self-health care measures in the nursing of patients with COPD can improve the lung function of patients and improve the nursing effect.The clinical application and promotion value are high. 2020 Vol. 27 (13): 209-211 [Abstract] ( 59 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 212 Application effect of irrigation combined with tooth-brushing in oral nuring of patients with tracheotomy YE Qin; GU Yuan; YANG Xiu-hua; GUO Lian-yi; LU Ning-yan; YANG Rong Objective To explore the application effect of the method of irrigation combined with tooth-brushing in oral nursing of patients with tracheotomy.Methods A total of 130 cases of tracheotomy in our hospital from September 2017 to May 2019 were selected as the research objects, they were divided into control group and experiment group according to random number table method，65 cases in each group.The control group was given traditional oral nursing, the experimental group was given irrigation combined with tooth-brushing.The incidence rate of halitosis, oral inflammation, oral bacteria infection, oral nursing time in two groups were compared.Results The incidence rates of oral bacteria infection after 3 and 7 days oral nuring in the experimental group were 23.08% and 9.23% respectively, the incidence rates of oral inflammation were 18.46% and 12.31% respectively, the incidence rates of halitosis were 10.78%and 7.69% respectively, while the incidence rates of oral bacteria infection after 3 and 7 days oral nuring in the control group were 35.38% and 15.38% respectively, the incidence rates of oral inflammation were 20.00% and 23.08% respectively, the incidence rates of halitosis were 24.62% and 20.00% respectively, the experimental group of patients with oral bacteria infection, oral inflammation and halitosis were lower than those of the control group, the differences were statistically significant (P＜0.05).The oral nursing time of the experimental group was (6.12±1.82 )min, while the control group was (7.25±2.55) min, the experimental group of oral nursing time was shorter than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Irrigation combined with tooth-brushing is beneficial to reduce halitosis and oral inflammation and oral bacteria infection in the experimental group, the experimental group can improve the quality of oral nursing in patients with tracheotomy effectively and shorten oral nursing time.It can improve the treatment effect and nursing efficiency and is worthy of application. 2020 Vol. 27 (13): 212-214 [Abstract] ( 71 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 215 Application effect of personal digital assistant graded nursing in cesarean section puerperae LIN Shao-hong; CAI Wei-lan; WANG Jing; ZHANG Yan-ping Objective To investigate application effect of personal digital assistant(PDA)graded nursing in cesarean section puerperae.Methods A total of 102 cesarean section puerperae treated in our hospital from July to December 2019 were selected as subjects.They were divided into two groups by random number table method, 51 cases in each group.In the control group, puerperae received traditional nursing, while in the observation group, puerperae received PDA graded nursing.The nursing work time, the total incidence of nursing adverse events and the total service satisfaction of puerperae between the two groups were compared.Results The time to draw temperature list, inquiry time of medical records, time to distribute medicine, time to record vital signs in the observation group were shorter than those in the control group, with statistically significant differences (P＜0.05).The total incidence of nursing adverse events in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The total service satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion PDA graded nursing in cesarean section in the maternal effect is very good,puerperae′s satisfaction is high, worthy of clinical application. 2020 Vol. 27 (13): 215-217 [Abstract] ( 61 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 218 Application effect of 5A nursing mode combined with structured health education in patients with type 2 diabetes FU Li Objective To explore the effect of 5A nursing mode combined with structured health education in patients with type 2 diabetes (T2DM).Methods Sixty patients with T2DM who were admitted to our hospital from January 2018 to May 2019 were selected and divided into observation group and control group, 30 cases in each group.The observation group used the structured health education combined with the 5A nursing model，and the control group used the traditional nursing method.Glycosylated hemoglobin (HbA1c), postprandial 2-hour blood glucose (2 h PBG), fasting blood glucose (FBG), self-efficacy score, disease uncertainty (MUIS) score，medication compliance (Morisky) score, total nursing satisfaction index were compared between two groups.Results The scores of HbA1c, 2 h PBG, FBG and MUIS in the observation group were lower than those in the control group, the differences were statistically significant(P＜0.05).The self-efficacy score, total satisfaction rate of nursing and Morisky score were higher in the observation group than in the control group, the differences were statistically significant (P＜0.05).Conclusion Structured health education combined with 5A nursing mode can effectively improve the overall satisfaction rate and self-efficacy of patients with T2DM, improve their blood sugar levels, and it is worth promoting. 2020 Vol. 27 (13): 218-220 [Abstract] ( 65 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 221 Application effect of comfort nursing on elderly patients with mental disorder FENG Jian-qian; ZHOU Zhi-cong; FU Chun-lian; CHEN Mei-ying; DENG Juan Objective To explore the application effect of comfort nursing on elderly patients with mental disorder.Methods Seventy-two elderly patients with mental disorders admitted to Mental Hospital of Guangzhou Civil Affairs Bureau and Home for the Aged Guangzhou from October 2017 to November 2018 were selected as the research subjects.They were divided into the routine group (n=36) and the comfort group (n=36) by random draw.Routine nursing intervention was carried out in the routine group, while comfort nursing intervention was carried out in the comfort group.The scores of activity of daily living scale (ADL), mini-mental state examination (MMSE), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) of the two groups were compared.Results After nursing intervention,the ADL score of the comfort group was lower than that of the routine group.The MMSE score of the comfort group was higher than that of the routine group.The SAS and SDS scores of the comfort group were lower than those of the routine group, the differences were statistically significant (P＜0.05).Conclusion The implementation of comfort nursing in the elderly patients with mental disorders can effectively improve the mental state of elderly patients with mental disorders and improve their cognitive function and daily living ability.It has good application effect. 2020 Vol. 27 (13): 221-223 [Abstract] ( 61 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 224 Application effect of targeted predictive nursing in patients with tendency of deep venous thrombosis of lower extremity after gynecologic tumor surgery YU Ai-zhen Objective To investigate the effect of targeted predictive nursing in patients with tendency of deep venous thrombosis (DVT) of lower extremity after gynecologic tumor surgery.Methods A total of 50 patients with gynecologic tumors postoperative DVT tendence of lower extremity admitted to our hospital from May 2017 to June 2019 were selected as research objects, according to the sequence of admission time, they were divided into control group and experimental group, 25 cases in each group.The control group received routine nursing intervention, and the experimental group used targeted predictive nursing, the incidence of DVT of lower extremities, clinical indicators, and patient nursing satisfaction were compared between two groups.Results The incidence of DVT in the lower extremities of the experimental group was lower than that of the control group, with statistical difference (P＜0.05).The blood flow velocity and anticoagulant factor Xa in the experimental group were higher than those in the control group, while the lower extremities circumference of the experimental group was smaller than that in the control group, the differences were statistically significant (P＜0.05).In the control group, prothrombin time （PT） and activated partial thromboplastin time(APTT) were longer than those of the control group, and the differences were statistically significant (P＜0.05).The nursing satisfaction score of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion For patients with postoperative venous tumors with tendency to DVT of the lower extremity, it is necessary to make a targeted assessment before surgery and give effective predictive nursing measures to reduce the incidence of DVT in the lower limbs after gynecologic tumor surgery.Patient nursing satisfaction plays an important role, and good measures are worthy of clinical promotion. 2020 Vol. 27 (13): 224-226 [Abstract] ( 57 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 227 Application of traditional Chinese medicine foot bath in patients with hand-foot syndrome caused by Oxaliplatin chemotherapy YE Peng; LI Ying-chun; YU Feng-yuan Objective To explore the application effect of traditional Chinese medicine foot bath in patients with Oxaliplatin chemotherapy-induced hand-foot syndrome (HFSR).Methods A total of 60 patients with HFSR caused by Oxaliplatin chemotherapy admitted to our hospital from July 2017 to August 2019 were selected as the study objects.The patients were divided into the control group and the observation group by random number table method, 30 cases in each group.The patients in both groups received routine nursing measures for HFSR.The control group received vitamin B6 orally, and the observation group received traditional Chinese medicine foot bath.The classification of HFSR before and after intervention was compared between the two groups.Results Before treatment, there was no statistically significant difference in the grade data of HFSR between the two groups (P＞0.05), and the observation group was better than that of the control group after treatment, with statistical difference (P＜0.05).Total effectiveness of intervention in the observation group was 93.33%, which was higher than that of the control group (73.33%).The onset time in the observation group was (3.21±0.54) d, earlier than that of the control group (9.17±1.42) d, with statistical differences (P＜0.05).No adverse reactions such as skin allergy or skin irritation occurred in the two groups of patients during the treatment.Conclusion Traditional Chinese medicine foot massage has a definite effect on HFSR caused by Oxaliplatin chemotherapy, can significantly reduce the classification of HFSR, has advantages of short onset time and high safety,and is worthy of clinical application. 2020 Vol. 27 (13): 227-229 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 230 Application of comprehensive nursing intervention in elderly schizophrenic patients DING Xi-lian Objective To explore the effect of comprehensive nursing intervention in elderly schizophrenic patients.Methods A total of 100 elderly schizophrenic patients admitted to our hospital from January to December 2018 were selected as the research objects.They were divided into intervention group and control group by random number table method, 50 cases in each group.The control group adopted routine nursing methods, while the intervention group adopted comprehensive nursing intervention measures.After 6 months of intervention, the total awareness rate of health knowledge, treatment compliance, incidence of adverse reactions and total nursing satisfaction were compared between the two groups.Results The treatment compliance, total health knowledge awareness rate and total nursing satisfaction of the intervention group were higher than those of the control group, and the total incidence of adverse reactions was lower than that of the control group, with statistical differences (P＜0.05).Conclusion Comprehensive nursing intervention can effectively improve the knowledge of the related diseases in the elderly schizophrenic inpatients, improve the patient′s doctor-based behavior, reduce the incidence of adverse reactions, and also increase the patient′s satisfaction with nursing services.It is worth promoting. 2020 Vol. 27 (13): 230-232 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 233 Effect of targeted nursing on prognosis of uremic hemodialysis patients HUANG Li; WANG Min; LUO Su-juan Objective To explore the effect of targeted nursing on the prognosis of hemodialysis (HD) patients.Methods A total of 60 patients with advanced uremia admitted to our hospital from September 2016 to March 2018 were selected as the research objects.They were divided into control group (n=30) and observation group (n=30) according to random number table method.The control group adopted routine nursing method, while the observation group adopted targeted nursing method.The intervention effects of the two groups were compared.Results The levels of serum creatinine and urea nitrogen in the observation group were lower than those in the control group, with statistical differences(P＜0.05), there were no significant differences in the levels of white blood cells, red blood cells, blood sodium and blood potassium between the two groups (P＞0.05); the levels of diastolic blood pressure (SBP), systolic blood pressure(DBP), mean arterial pressure (MAP) in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).The score of quality of life in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Targeted nursing has a good effect on HD patients.It can improve the serum creatinine level and urea nitrogen level，reduce the levels of SBP, DBP and MAP, while it has a good stability on the levels of white blood cells，red blood cells，, blood sodium and blood potassium, and improve the quality of life of patients. 2020 Vol. 27 (13): 233-235 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 236 Application of comprehensive nursing intervention in patients with colostomy after operation of low rectal cancer SUN Hui Objective To investigate the application of comprehensive nursing intervention in colostomy fistula after low rectal cancer.Methods The clinical data of 86 cases of colostomy after operation for low rectal cancer treated in our hospital from February 2017 to February 2019 were retrospectively analyzed.They were divided into group A (n=43) and group B (n=43) according to difference the nursing methods.Group A used conventional nursing methods,group B used comprehensive nursing intervention.The quality of life, complications and self-nursing ability were compared between the two groups.Results The quality of life score([33.07±4.92]points)was lower in group A than in group B([44.29±4.51]points)，and the difference was statistically significant (P＜0.05).The incidence of complications in group B was 4.65%, which was lower than 18.60 % in group A, and the difference was statistically significant (P＜0.05).Patients in group B scored were higher than group A in self-care management such as self-concept, self-care responsibility, self-care knowledge, and self-care skills, the differences were statistically significant (P＜0.05).Conclusion Comprehensive nursing intervention for patients with postoperative colostomy of low rectal cancer can reduce the incidence of various complications and improve the patients′ self-management ability and quality of life, which is worthy of promotion and application. 2020 Vol. 27 (13): 236-238转242 [Abstract] ( 55 ) HTML (34 KB)  PDF  (0 KB)  ( 12 ) 239 Application effect of family companion perinatal nursing in women with depression tendency YANG Wei Objective To observe the effect of family companion perinatal nursing in women with depression.Methods A total of 106 women with depressive propensity who were admitted to our hospital from January 2017 to December 2018 were selected.According to the admission time, 53 women who were admitted in 2017 were included in the routine group, and 53 women who were admitted in 2018 were included in the family group.The routine group used routine perinatal nursing, and the family group used family companion perinatal nursing.The maternal and child outcomes and the complications of childbirth were compared between the two groups.The mental state of the two groups was evaluated 5 days after delivery.The follow-up period was 1 month.The incidence of postpartum depression and psychotic symptoms in the two groups was evaluated.Results The natural delivery rate of the family group was 83.02%, the neonatal abnormal rate was 5.66%, the difficult labor rate was 15.09%, the total labor time was (5.23±1.21) h, and the routine group was 64.15%, 22.64%, 32.08%, (8.46±1.35) h, the natural delivery rate of the family group was higher than that of the routine group, the abnormal rate of the newborn, and the dystocia were lower than those of the routine group.The total maternal duration of the family group was shorter than that of the routine group, and the differences were statistically significant (P＜0.05).The incidence of lactation, constipation and wound infection were lower than the routine group, the differences were statistically significant (P＜0.05).On the 5th days after delivery, the family group maternal Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), negative and the positive symptom scale(PANSS) scores were lower than the routine group, the differences were statistically significant (P＜0.05).The follow-up period of 1 month，the incidence of postpartum depression (PPD) in the family group was 9.43%, accompanied by psychotic symptoms for 1.89%, were lower than that of the routine group for 24.53% and 13.21%, respectively, the differences were statistically significant (P＜0.05).Conclusion Family companion perinatal nursing can effectively improve the mental state of women with depression tendency, reduce the risk of maternal and child adverse outcomes, and prevent maternal postpartum depression to certain extent. 2020 Vol. 27 (13): 239-242 [Abstract] ( 54 ) HTML (36 KB)  PDF  (0 KB)  ( 11 ) 243 Application effect of personalized nursing on persistent headache after intracranial aneurysm intervention ZHANG Zhi-hong Objective To explore effect of personalized nursing on persistent headache after intracranial aneurysm intervention.Methods A total of 80 cases with severe headache after aneurysm interventional therapy admitted to our hospital from December 2017 to May 2019 were selected as research objects and divided into observation group (n=40)and control group (n=40) according to random number table method.The control group were received routine nursing while the observation group were received individualized nursing in this study.Then the incidence of neck pain, dizziness, headache, nausea and vomiting after intervention were compared between the two groups.The ultrasound indexes(vertebral artery diameter, blood flow velocity and resistance index) of the affected vertebral artery after intervention were compared between the two groups.The clinical intervention effects in the two groups of patients were compared.Results After intervention, the incidence of neck pain, dizziness and headache, nausea and vomiting in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After intervention, the diameter of vertebral artery in the affected side of the observation group was larger than control group, average blood flow velocity was faster than control group, the resistance index was smaller than control group, the differences were statistically significant (P＜0.05).The total efficiency in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Individualized nursing intervention for patients with persistent headache caused by intracranial aneurysm can significantly improve headache symptoms, cerebral blood supply and clinical therapeutic effect. 2020 Vol. 27 (13): 243-245 [Abstract] ( 62 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 246 Application of self-efficacy intervention in elderly parturient LU Jun-yan； GONG Li-na Objective To explore the application effect of self-efficacy intervention in the elderly parturient.Methods A total of 192 elderly women in our hospital from August 2018 to August 2019 were selected as research objects, according to the random number table method, the patients were divided into observation group (n=96) and control group (n=96).The control group received routine nursing,on the basis of routine nursing,the observation group received self-efficacy intervention.The time of delivery, pregnancy outcome, negative emotion and self-efficacy were compared between the two groups.Results After intervention,the scores of Zung self rating anxiety scale (SAS)and Zung self rating depression scale (SDS) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The vaginal delivery rate of the observation group was higher than that of the control group, and the incidence of fetal distress, neonatal asphyxia and perinatal mortality was lower than that of the control group, the differences were statistically significant(P＜0.05).The first stage,the second stage and the third stage of labor in the observation group were shorter than those in the control group, the differences were statistically significant (P＜0.05).The scores of self-efficacy expectation scale （EE-16）, outcome expectation scale （OE-16） and simplified Chinese version of labor self-efficacy scale （CBSEI-C32） in the observation group were higher than those in the control group, the differences were statistically significant(P＜0.05).Conclusion On the basis of routine nursing, self-efficacy intervention can significantly shorten the delivery process of elderly women, reduce negative emotions, improve the level of self-efficacy and vaginal delivery rate, reduce the incidence of adverse outcomes of newborns, which deserves clinical attention. 2020 Vol. 27 (13): 246-249 [Abstract] ( 55 ) HTML (38 KB)  PDF  (0 KB)  ( 10 ) 250 Application effect of evidence-based nursing in patients with severe viral hepatitis DENG Guo-mei； DENG Guo-xia； HU Qing-qing； YU Di-ya Objective To evaluate the application effect of evidence-based nursing in patients with severe viral hepatitis.Methods A total of 100 patients with severe viral hepatitis admitted to the Ninth Hospital of Nanchang from January 2017 to December 2018 were enrolled in this research.According to the order of admission, patients were divided into control group (n=50) and observation group (n=50) in odds/even number.The control group was provided routine nursing and the observation group was provided evidence-based nursing respectively.The nursing effect of the two groups was compared.Results The level of physical elasticity of the observation group was higher than that of the control group and the total complication rate was 2.0%, lower than that of the control group accounting for 18.0% (P＜0.05).The nursing satisfaction score of the observation group was (92.48±5.19) points, higher than that in the control group of (84.12±5.20) points, with statistical difference (t=8.046, P=0.000).Conclusion Evidence-based nursing intervention has a significant effect on patients with severe viral hepatitis.It can alleviate psychological barriers, provide necessary emotional support, and has high clinical value, worthy of promotion and application. 2020 Vol. 27 (13): 250-253 [Abstract] ( 61 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )

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