早期足量用伐昔洛韦联合糖皮质激素与单用伐昔洛韦在中老年带状疱疹患者中的应用效果

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Abstract Objective To explore the effect and safety of Valaciclovir alone and early adequate Valaciclovir combined with Glucocorticoid in the treatment of middle-aged and elderly patients with herpes zoster.Methods Seventy-five middle-aged and elderly patients with herpes zoster who were treated in our hospital from October 2018 to September 2019 were selected as subjects.They were divided into the single group (37 patients) and the combination group (38 patients) by alternating grouping method, the single group was treated with Valacyclovir, and the combination group was treated with early adequate Valaciclovir combined with Glucocorticoid.The pain disappearance time, stagnation time,scarring time, total effective rate of treatment and total incidence of adverse reactions were compared between the two groups.Results The pain disappearance time, stagnation time and scarring time in the combination group were shorter than those in the single group, and the differences were statistically significant (P＜0.05).The total effective rate of treatment in the combination group (97.74%) was higher than that in the single group (72.97%), the total incidence of adverse reactions in the combination group (2.63%) was lower than that in the single group (18.92%), the differences between the two groups were statistically significant (P＜0.05).Conclusion The combination of Glucocorticoid and early adequate Valaciclovir in the treatment of middle-aged and elderly patients with herpes zoster has better effect, can effectively improve the clinical symptoms, reduce the incidence of adverse reactions, and has better safety, which is worthy of clinical promotion.

Key words： Herpes zoster Valaciclovir Glucocorticoid Therapeutic effect Safety

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	ZHANG Lin

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ZHANG Lin. Application effect of early adequate Valaciclovir combined with Glucocorticoid and Valaciclovir alone in the treatment of middle-aged and elderly patients with herpes zoster[J]. 中国当代医药, 2020, 27(13): 145-147.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I13/145

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