甲巯咪唑与丙硫氧嘧啶治疗甲状腺功能亢进症的临床效果比较

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Abstract Objective To compare the clinical application effect of Methimazole and Propylthiouracil in the treatment of thyroid glands syndrome (hereinafter referred to as hyperthyroidism).Methods A total of 114 patients with hyperthyroidism admitted to our hospital from January 2018 to June 2019 were selected as the study subjects.The patients were divided into normal group (57 cases) and scientific research group (57 cases) by random number table method.The patients in normal group were treated with Propylthiouracil.The patients in the scientific research group were treated with Methimazole.The thyroid hormone levels at different time stages (before treatment, 60 and 90 days after treatment), the total incidence of adverse reactions, the treatment time, the length of stay and the time of symptom improvement were compared between the two groups.Results After 60 and 90 days of treatment, the levels of free triiodothyronine (FT3)and free thyroxine (FT4) in the scientific research group were lower than those in the normal group, with statistically significant differences (P＜0.05).The levels of thyroid-stimulating hormone (TSH) in the scientific research group after 60 and 90 days of treatment were higher than those in the normal group, and the differences were statistically significant (P＜0.05).The overall incidence of adverse reactions in the scientific research group was lower than that in the normal group, and the difference between the two groups was statistically significant (P＜0.05).There was no significant difference in treatment time between the two groups (P＞0.05).The length of stay and symptom improvement time of patients in the scientific research group were shorter than those in the normal group, and the differences were statistically significant (P＜0.05).Conclusion After comparing the clinical effect and safety of Methimazole with that of Propylthiouracil in the treatment of hyperthyroidism, the safety of Methimazole is higher and the incidence of adverse reactions can be reduced obviously.But in the actual treatment process should still be combined with the patient′s condition to choose different drugs, its blood routine, liver function changes for careful observation.

Key words： Methimazole Propylthiouracil Thyroid glands syndrome Safety Clinical application Analysis

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	WANG Ming

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WANG Ming. Clinical effect comparison of Methimazole and Propylthiouracil in the treatment of thyroid glands syndrome[J]. 中国当代医药, 2020, 27(13): 141-144.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I13/141

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