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| Application of thyroxine in patients with pregnancy complicated with hypothyroidism |
| DENG Xia-mei LUO Yun-shan |
| Department of Obstetrics, Shaoguan Yuebei People′s Hospital, Guangdong Province, Shaoguan 512026, China |
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Abstract Objective To explore the application of thyroxine in patients with pregnancy complicated with hypothyroidism.Methods A total of 96 patients with pregnancy complicated with hypothyroidism who were treated in our hospital from August 2017 to July 2019 were selected.They were divided into the control group and the study group according to the digital parity method, 48 cases in each group.The control group was treated with conventional iodine supplementation, while the study group was given thyroxine.The thyroid hormone level, progesterone level, and maternal and child outcomes were compared between the two groups.Results There were no significant differences in serum thyroid stimulating hormone (TSH) level, free thyroid hormone (FT4) level, and free triodothyronine (FT3) level between the two groups before treatment (P＞0.05).After treatment, the TSH level in the study group was lower than that in the control group, the FT4 and FT3 levels in the study group were higher than those in the control group, with statistical differences (P＜0.05).There was no statistically significant difference in the progesterone level between the two groups before treatment (P＞0.05).The progesterone level in the study group was higher than that in the control group after treatment, with statistical difference (P＜0.05).There was no statistically significant difference in the hypersensitive C-reactive protein (hs-CRP) level between the two groups before treatment (P＞0.05).The hs-CRP level in the study group was lower than that in the control group after treatment, with statistical difference (P＜0.05).The total incidence of complications, such as gestational hypertension, intrahepatic cholestasis of pregnancy, and fetal distress, in the study group was lower than that in the control group, with statistical difference (P＜0.05).The incidences of preeclampsia, early abortion and fetal malformation in the study group were lower than those in the control group, with statistical differences (P＜0.05).The weight of newborns in the study group was higher than that in the control group, with statistical difference (P＜0.05).Conclusion Thyroxine can improve thyroid hormone and elevate progesterone level in patients with pregnancy complicated with hypothyroidism.It can also improve maternal and infant outcomes, with significant clinical value.
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| [1] |
张月芳，叶飞雪，田玉华.左甲状腺素钠片治疗对妊娠合并甲状腺功能减退患者甲状腺激素、血脂水平的影响[J].内科，2019，14（3）：271-273.
|
| [2] |
胡会平.左甲状腺素钠治疗妊娠合并甲减的效果及对患者血清TSH 水平影响[J].北方药学，2019，16（5）：128-129.
|
| [3] |
鲁辛，朱巍，张晶，等.甲状腺素治疗对妊娠合并甲减患者甲状腺激素、血清叶酸、孕酮水平及母婴结局的影响[J].四川医学，2019，40（4）：405-409.
|
| [4] |
李金鸽，贺译平，徐叶红，等.不同剂量左旋甲状腺素对妊娠合并甲减患者胎儿发育的影响[J].现代生物医学进展，2019，19（7）：1321-1324.
|
| [5] |
文立莲.左甲状腺素钠片治疗对妊娠合并甲减患者妊娠结局及子代的影响[J].中国处方药，2019，17（2）：63-64.
|
| [6] |
刘乐.甲状腺素治疗对妊娠合并甲减患者妊娠结局及子代的影响[J].首都食品与医药，2019，26（1）：35.
|
| [7] |
宋俊杰，李彩霞，申爱琴.妊娠合并甲状腺功能减退对先兆流产及妊娠结局的影响[J].临床医学，2018，38（8）：41-43.
|
| [8] |
崔健.不同剂量左旋甲状腺素钠片治疗妊娠合并甲减的临床效果分析[J].中国合理用药探索，2018，15（8）：12-14.
|
| [9] |
刘新胜.左旋甲状腺素治疗妊娠期亚临床甲减对孕妇甲状腺功能及母婴结局的影响研究[J].山西职工医学院学报，2018，28（3）：49-51.
|
| [10] |
郑春兰.左甲状腺素对妊娠合并亚临床甲减患者围生结局及安全性的影响[J].慢性病学杂志，2018，19（6）：772-773，776.
|
| [11] |
甄世萍，卢杉.妊娠合并甲状腺功能减退对妊娠和胎儿的影响探讨[J].基层医学论坛，2018，22（16）：2191-2192.
|
| [12] |
马丹，邬雪容，袁航路.左旋甲状腺素治疗对妊娠期糖尿病合并亚临床甲减母婴结局的影响[J].实用临床医学，2018，19（5）：68-69，75.
|
| [13] |
王国坤.小剂量左甲状腺素替代治疗对高龄老年慢性心衰合并亚甲减患者的疗效观察[J].中国卫生标准管理，2018，9（9）：82-84.
|
| [14] |
肖立，牛建民.妊娠合并甲状腺功能异常：子痫前期风险与防范[J].中国实用妇科与产科杂志，2018，34（5）：499-503.
|
| [15] |
王丽萍，王淑，胡虹宇，等.左甲状腺素钠治疗妊娠合并甲减的效果观察[J].中国民康医学，2018，30（8）：30-31.
|
| [16] |
侯洁.甲状腺素治疗对妊娠合并甲减患者妊娠结局及子代的影响研究[J].中国现代医生，2018，56（11）：50-52.
|
| [17] |
白伶俐，芦笛.左旋甲状腺素配合常规治疗对妊娠合并甲状腺功能减低产妇胎盘环氧合酶-2、核因子-κB 的影响[J].中国妇幼保健，2018，33（5）：1022-1025.
|
| [18] |
左敏毅.左旋甲状腺素联合右归丸治疗妊娠合并亚临床甲状腺功能减退症患者的疗效及对Hcy、SOD、25-（OH）-D 与叶酸水平的影响[J].中国妇幼保健，2018，33（3）：567-569.
|
|
|
|
