依达拉奉在全麻下行胸腔镜下食管癌根治术患者中的应用效果

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Abstract Objective To investigate the application effect of Edaravone in patients undergoing thoracoscopic esophagectomy under general anesthesia.Methods A total of 60 patients undergoing thoracoscopic esophagectomy under general anesthesia in Qingdao Municipal Hospital from December 2016 to August 2017 were selected as the research subjects, aged 35-68 years old, with American Society of Anesthesiologists (ASA) Ⅰ-Ⅱgrades.All patients were divided into EI group and CG group according to the random number table method, 30 cases in each group.Patients in the EI group were given intravenous infusion of Edaravone 30 mg in 0.9% sodium chloride 100 ml after induction of anesthesia, while those in the CG group were given intravenous infusion of equal amounts of sodium chloride after induction of anesthesia.The venous blood samples were obtained at the following time points respectively：before skin incision after anesthesia (T0), one lung ventilation 60 min (T1), one lung ventilation 90 min (T2), one lung ventilation 120 min (T3), dilated lung 30 min (T4) and 60 min after operation (T5), and enzyme-linked immunosorbent assay(ELISA) was used to detect phosphatidyl inositol 3-kinase (PI3K), phosphorylated protein kinase B (p-AKT), activating protein-1 (AP-1), and interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD) expression levels.The operation of the two groups of patients was compared.Results There were no significant differences in the operation time, intraoperative one lung ventilation time, anesthesia time, operation path, and post-anesthesia care unit (PACU) time between the two groups (P＞0.05).The expression levels of PI3K, p-AKT, AP-1, IL-8 and TNF-α in the plasma of the two groups at T1-T5 were higher than those at T0, and the differences were statistically significant (P＜0.05).The expression levels of SOD in the plasma of the two groups at T1-T5 were lower than those at T0, and the differences were statistically significant (P＜0.05).The expression levels of PI3K, p-AKT, AP-1, IL-8 and TNF-α in the plasma of patients in EI group at T1-T5 were lower than those in CG group, and the differences were statistically significant (P＜0.05).The expression levels of SOD in the plasma of patients in EI group at T1-T5 were higher than those in CG group, and the differences were statistically significant (P＜0.05).Conclusion Edaravone has a protective effect on one lung ventilation-induced lung injury, and reduces the postoperative pulmonary inflammatory response by reducing the release of pro-inflammatory cytokines.

Key words： Edaravone One lung ventilation Lung injury

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	Articles by authors
	TANG Yu-ru
	SHUAI Xun-jun
	XU Tang-wen
	LI Hui
	SUN Chang-rong
	AI Deng-bin

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TANG Yu-ru,SHUAI Xun-jun,XU Tang-wen, et al. Application effect of Edaravone in patients undergoing thoracoscopic esophagectomy under general anesthesia[J]. 中国当代医药, 2020, 27(13): 107-110.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I13/107

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