中国当代医药
      Home                              中文
中国当代医药
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2018 Vol. 25, No. 1
Published: 2018-01-08
 
 
4 Protection mechanism of intermittent hypoxia on heart ischemia/reperfusion injury in rats
WANG Yuan-yuan;CAO Jian; WAN Jian-hua
Objective To study the expression of phosphatidylinositide 3-kinase signaling pathway(PI3K),hypoxia-inducible factor 1α (HIF-1α),vascular endothelial growth Factor-2(VEGF-2)and to studied the correlation protection mechanism of intermittent hypoxia on heart ischemia/reperfusion(I/R)injury in rats.Methods 72 rats were randomly divided into the sham-operated group(n=18),the myocardial I/R group(n=18),the myocardial I/R+intermittent hypoxia(IH)group(I/R+IH)(n=18)and the myocardial I/R+IH+phosphatidylinositide 3-kinase(PI3K)inhibitor(wortmannin)group(IH+I/R+PI3K inhibitor group)(n=18).Mice were exposed to cycles to establish the IH model.I/R model was established by ligating the left anterior descending coronary artery.The MDA and GSH of cardic muscle tissues,and the serum biomarkers CK-MB in the four groups were detected.The LV end-diastolic volume(LVEDV),LV end-systolic(LVESV),LV ejection fraction(LVEF)of the rats by echocardiography after 8 weeks were assessed.The expression of phosphorylation of protein kinase B (Akt),HIF-1α,VEGF-2 was analyzed by Westen-blot.Results The level of MDA,CK-MB,LVEDV,LVESV of the I/R group was higher than that of the sham-operated group,the value of GSH,LVEF and the expression of AKt,HIF-1α,VEGF-2 of the I/R group was lower than that of the sham-operated group,with significant difference (P＜0.05).The level of MDA,CK-MB,LVEDV,LVESV of the I/R+IH group was lower than that of the I/R group,the value of GSH,LVEF and the expression of AKt,HIF-1α,VEGF-2 of the I/R+IH group was higher than that of the I/R group,with significant difference(P＜0.05).The level of MDA,CK-MB,LVEDV,LVESV of the I/R+IH+PI3K inhibitor group was higher than that of the sham-operated group,the value of GSH,LVEF and the expression of AKt,HIF-1α,VEGF-2 of the I/R+IH+PI3K inhibitor group was lower than that of the sham-operated group,with significant difference(P＜0.05).Conclusion The PI3K/Akt pathway and the expression of HIF-1α,VEGF-2 is important for IH-induced cardioprotection and may represent aviable target to reduce myocardial I/R injury.
2018 Vol. 25 (1): 4-7 [Abstract] ( 194 ) HTML (37 KB)  PDF  (0 KB)  ( 37 )
8 Clinical application of sedative analgesia with alone Sufentanil in endoscopic hemostasis in patients with upper gastrointestinal hemorrhage
QIU Chun-hua;ZHENG Xiao-ling;WU Wei-lan;CHEN Yan-qing
Objective To investigate the overall efficacy and safety of sedative analgesia with alone Sufentanil in endoscopic hemostasis in patients with upper gastrointestinal hemorrhage.Methods60 patients received endoscopic hemostasis in our hospital from October 2016 to August 2017 were selected and randomly divided into the low dose Sufentanil+Propofol group(the PS group,n=30)and the Sufentanil group(the S group,n=30).The anesthesia effect,PACU residence time,vital signs,the incidence rate of adverse events and the satisfaction degree of patients and endoscopic were observed.Results The heart rate,mean arterial pressure and pulse oximetry during surgery of the PS group were significantly higher than those of the S group(P＜0.01).The incidence rate of severe hypotension and severe respiratory depression in the PS group were higher than that in the S group(P＜0.01).And the PACU residence time of the PS group was significantly longer than that of the S group (P＜0.01).There was no significant difference in the incidence rate of adverse events such as nausea,hematemesis,cough,severe physical activity between the two groups.And there was no significant differences in patient satisfaction degree and endoscopic satisfaction degree between the two groups(P＞0.05).Conclusion Sedative with alone Sufentanil also provides a good surgical environment and patient experience for upper digestive haemorrhagic endoscopic hemostasis and provides a safer environment for intravenous anesthesia than Propofol.
2018 Vol. 25 (1): 8-10转15 [Abstract] ( 159 ) HTML (33 KB)  PDF  (0 KB)  ( 34 )
11 Preparation of Esomeprazole Magnesium enteric-coated pellets-type tablets
LIU Xiu-min;XU Wei-feng
Objective To Study on the preparation method of Esomeprazole Magnesium enteric-coated pellets-type tablets.Methods The enteric-coated Esomeprazole Magnesium pellets were prepared by fluid bed bottom spray coating method,the Esomeprazole Magnesium pellets were prepared by direct compression of the enteric-coated pellets and suitable excipients.Results The drug layer contained 7%of the HPC-SSL aqueous solution as the binder,adding 5%of the Esomeprazole Magnesium raw materials and 3%talc as anti-binder agent,prepared into drug-containing pellets.Isolation layer contained 5%HPC-SSL aqueous solution as the coating material,coating weight gain of 15%to 20%.The ratio of enteric materials Eudragit L30D-55/NE30D was 9∶1,the coating weight gain was 40%,enteric-coated pellets/excipients(Lactose/MCC/PVPP=140∶80∶25)was 1∶1,the enteric-coated tablets releasen in 0.1 mol/L hydrochloric acid in 2 h was less than 10%,while in pH 6.8 Phosphate buffer in 45 min was more than 75%.Conclusion The release behavior of Esomeprazole Magnesium enteric-coated pellets prepared by the above method is preferred,and it may be used in industrial production.
2018 Vol. 25 (1): 11-15 [Abstract] ( 154 ) HTML (40 KB)  PDF  (0 KB)  ( 31 )
16 Research on the preformulation of Dexibuprofen Sustained-Release Dry Suspensions
XU Jie-hong;GAO Ying;CAO Qing-ri
Objective To determine the solubility of drug in different media,to evaluate the stability of raw material and drug/excipient interactions for the development of Dexibuprofen Sustained-Release Dry Suspensions.Methods The solubility of the drug was determined indifferent pH buffer solutions(pH 1.2,pH 4.5,pH 5.0,pH 6.8 and pH 7.4),water and ethanol.The related substances of raw material were analyzed at the 5th and 10th days after storage under high temperature(60℃),high humidity(RH 92.5%)and strong light(4500 Lx).The drug-excipient interactions were also studied at the 5th and 10th days under high temperature(60℃),high humidity(RH 92.5%)and strong light(4500 Lx).Results The solubility of drug increased as the pH of solution increased in the range from pH 1.2 to pH 7.4.The drug was highly soluble in ethanol.The related substances of raw material slightly increased under high temperature and showed hygroscopicity under high humidity.But the related substancesafter storage under three different conditions were all less than 0.3%.The related substances from drug-excipient interactions under three conditions were below 0.3%.Conclusion The drug solubility showed a pH dependent manner.The raw material was quite sensitive to high temperature.No drug-excipientinteractions were observed between the drug and excipients.
2018 Vol. 25 (1): 16-18 [Abstract] ( 172 ) HTML (28 KB)  PDF  (0 KB)  ( 37 )
19 Risk factors of pancreaticfistula after pancreaticoduodenectomy
LI Ze-feng;ZHAO Hao-liang;YANG Lin
Pancreatoduodenectomy is still a routine procedure for the benign and malignant disease around the head of the pancreas and the abdomen.This operation is basically the biggest operation in abdominal surgery.It involves more viscera and is difficult to operate.With the improvement of surgical doctor technology,rich experience,and perioperative and postoperative management of standardization,reasonable mortality reported significantly lower,but the incidence of postoperative complications(18.5%-50.0%)is still not very satisfactory.The occurrence of pancreatic fistula is one of the most important complications of the operation,which is one of the main reasons for the increase in mortality of patients and the extension of time in hospital.Therefore,the possible risk factors for the occurrence of pancreatic fistula after PD surgery are reviewed with the existing reports and clinical observations.
2018 Vol. 25 (1): 19-22 [Abstract] ( 171 ) HTML (34 KB)  PDF  (0 KB)  ( 36 )
23 Effect of laparoscope treating acute senility appendicitis
SI Yu-guang; LI Jie
Objective To investigate the effect of laparoscope treating acute senility appendicitis and its influence of postoperative inflammatory cytokine and sleep quality in patients.Methods The clinical data of 90 patients with acute senility appendicitis treated in our hospital from March 2015 to August 2016 was retrospectively analyzed.All patients were divided into the laparoscopic group(n=50)and laparotomy group(n=40)according to surgical procedure.The general operation condition was observed in patients of the two groups,and the postoperative recovery,preoperative and postoperative inflammatory cytokines,incidence of complications and sleep quality were compared inpatients between the two groups.Results The operation time of the laparoscopy group was longer than that in the laparotomy group,the amount of bleeding during the operation was fewer than that in the laparotomy group,and the length of the incision was shorter than that in the laparotomy group(P＜0.001).In the laparoscopy group,the exhaust,the ambulation and the postoperative hospital stay were shorter than those in the laparotomy group(P＜0.001).There was no significant difference in inflammatory cytokine level between the two groups before operation(P＞0.05)，and the level of CRP and WBC in the laparoscopic group was lower than that in laparotomy group at after 1 d operation (P＜0.05).There was no significant difference in the sleep quality score between the two groups before operation(P＞0.05),and the sleep quality score of the laparoscopic group was better than that of the laparotomy group after 3 d operation (P＜0.05).There was no significant difference in the incidence of postoperative complications between the two groups (χ2=0.621,P=0.431).Conclusion Laparoscopic appendectomy for acute senility appendicitis has good therapeutic effect and less trauma,which plays a positive significance in promoting the postoperative rehabilitation of patients.
2018 Vol. 25 (1): 23-26 [Abstract] ( 164 ) HTML (34 KB)  PDF  (0 KB)  ( 39 )
27 Analysis of risk factors of infection in aplastic anemia
HE Hong-xiu;LI Qin;LI Xiao-ming
Objective To investigate the infection characteristics and risk factors of aplastic anemia patients to provide the theoretical basis for effective prevention and treatment.Methods 330 patients with aplastic anemia treated in the Hematology Department of Affiliated Hospital of Southwest Medical University from May 2013 to May 2017 were selected as object.Retrospective investigation and analysis method was used to analyze the related infection characteristics and the related risk factors of patients.Data were analyzed by SPSS 17.0 software.Results Among 330 patients with aplastic anemia,128 cases had infections(38.8%),46 cases of hospital infection(35.9%),82 cases of community infection(64.1%),111 cases of single infection(86.7%),14 cases of double infection(10.9%),3 cases of multiple infection(2.4%).A total of 19 cases of pathogenic bacteria were trained,Gram-negative bacteria in 12 case(63.2%),Gram-positive bacteria in 4 cases(21.1%),fungal infections in 3 cases(15.7%).Single factor analysis showed that the hospitalization time,white blood cell count,neutrophils count,agranulocytosis duration,albumin content,invasive operation and the application of hormone were risk factors for infection in patients with aplastic anemia (P＜0.01).Multivariate analysis showed that the hospitalization time,agranulocytosis duration,albumin content,number of neutrophils were independent risk factors for aplastic anemia with infection (P＜0.01).Conclusion In clinic,positive and effective preventive measures should be taken according to the above risk factors to reduce the incidence of infection in patients with aplastic anemia.
2018 Vol. 25 (1): 27-30 [Abstract] ( 165 ) HTML (33 KB)  PDF  (0 KB)  ( 34 )
31 ClinicaleffectanalysisofendoscopictitaniumclipcombinedwithEpinephrine Injection in the treatment of non-varicose upper gastrointestinal hemorrhage
LIANG Ming-chao;WANG Xiao-gu;OUYANG Xin-qiang;CHEN Zhao-da;GONG Jian-an
Objective To explore the clinical effect of endoscopic titanium clip combined with Epinephrine Injection in the treatment of non-varicose upper gastrointestinal hemorrhage.Methods 32 patients with non-varicose upper gastrointestinal hemorrhage treated in our hospital from January 2014 to January 2017 were selected as the object and they were randomly divided into the control group and observation group using the computer random number grouping method,and there were 16 cases in each group.Patients in the control group were given simple endoscopic Epinephrine Injection treatment,while patients in the observation group were given endoscopic titanium clip combined with Epinephrine Injection treatment.The total effective rate,immediate hemostasis rate,hemostasis time,defervescence time,re-bleeding rate,the incidence of adverse reaction and quality of life score were compared in patients between the two groups.Results The total effective rate and the immediate hemostasis rate of the observation group were higher than those of control group (P＜0.05).The hemostasis time and defervescence time of the observation group were shorter than those of the control group (P＜0.05).The re-bleeding rate was 0 in the observation group,which was significantly lower than that of the control group (25.00%)(P＜0.05).The incidence of adverse reaction of the observation group was significantly lower than that of the control group (P＜0.05).The score of quality of life in all aspects of the observation group were higher than those of control group(P＜0.05).Conclusion Eendoscopic titanium clip combined with Epinephrine Injection in the treatment of non-varicose upper gastrointestinal hemorrhage has a significant effect,and it can effectively stop bleeding and remove fever,reduce the occurrence of rebleeding and adverse reactions,and improve the quality of life of patients.
2018 Vol. 25 (1): 31-33 [Abstract] ( 184 ) HTML (30 KB)  PDF  (0 KB)  ( 37 )
34 Curative efficacy comparison of prone position and left lateral position thoracoscopic esophagectomy applied in esophageal cancer under T3N1M0
LI Guan-ran;FANG Yuan;WANG Yang;ZHANG Qing-hua
Objective To compare the treatment effect of prone position and left lateral position thoracoscopic esophagectomy applied in esophageal cancer under T3N1M0.Methods From January 2013 and September 2015,78 patients with esophageal cancer under T3N1M0of clinical stages treated in Dalian Central Hospital were selected and they were divided into group A (prone position thoracoscopic esophagectomy)and group B (left lateral position thoracoscopic esophagectomy)according to the random number table method,and there were 39 cases in each group.Surgical related indexes,the incidence of postoperative complications and prognostic indicators in patients between the two groups were compared.Results The operation time of group A([215.2±16.1]min)was obviously shorter than that of group B([286.8±32.6]min),the amount of bleeding during operation of group A([278.5±21.5]ml)was obviously fewer than that of group B([357.7±33.0]ml),the number of lymph nodes of group A([8.5±1.2])was obviously more than that of group B([6.2±0.8]),the differences were statistically significant(P＜0.05).The incidence of postoperative complications and the fatality rate in group A were not significantly different from that in group B(P＞0.05).Conclusion For esophageal cancer under T3N1M0,surgical outcomes are similar between prone position and left lateral position thoracoscopic esophagectomy,but the operation time of prone position operation is shorter and it is more favorable for cleaning the lymph nodes.
2018 Vol. 25 (1): 34-36转40 [Abstract] ( 180 ) HTML (33 KB)  PDF  (0 KB)  ( 36 )
37 Clinical research of interventional therapy after thrombolysis and direct interventional therapy treating acute myocardial infarction
LIU Zhi-jian;XU Hui-lin;DONG Meng-shu
Objective To investigate clinical effect of interventional therapy after thrombolysis and direct interventional therapy treating acute myocardial infarction.Methods 132 patients with acute myocardial infarction diagnosed and treated in our hospital were selected from August 2014 to August 2016,and they were divided into the two groups using the random number table method.66 patients in the control group were given interventional therapy after thrombolysis,while 66 patients in the observation group were given direct interventional therapy.Cardiac function assessement and clinical parameters detection before and after treatment were conducted,and clinical curative efficacy and the incidence of complications were compared between the two groups.Results Left ventricular end diastolic diameter,left ventricular end diastolic volume index,cardiac function classification were decreased in patients of the two groups after treatment and left ventricular ejection fraction,creatine kinase isoenzyme,N-terminal pro brain natriuretic peptide,TIMI blood flow classification were increased,6 min walking distance were increased in the two groups after treatment(P＜0.05).Left ventricular end diastolic diameter,left ventricular end diastolic volume index,cardiac function classification,the total incidence of complication in the observation group were lower than those of the control group after treatment(P＜0.05).Left ventricular ejection fraction,creatine kinase isoenzyme,N-terminal pro brain natriuretic peptide,TIMI blood flow classification and the total effective rate were higher than those of the control group and 6 min walking distance in observation group were longer than those of the control group after treatment(P＜0.05).Postoperative hospitalization time in the observation group was shorter than that of the control group(P＜0.05).Conclusion Interventional therapy after thrombolysis and direct interventional therapy are effective methods treating acute myocardial infarction,and the effect of direct interventional therapy is better.
2018 Vol. 25 (1): 37-40 [Abstract] ( 139 ) HTML (32 KB)  PDF  (0 KB)  ( 30 )
41 Effect evaluation of alginate functional dressing stuffing the wound after complex anal fistula
LIAO Zhi-ping YE Hong-ping LIN Miao-hong
Objective To explore the effect of alginate functional dressing (AFD)stuffing the wound after complex anal fistula.Methods64 patients with complex anal fistula treated in our hospital from January 2016 to June 2017 were selected and they were randomly divided into the observation group (n=32)and control group (n=32).The control group was treated with vaseline oil yarn packing while the observation group was treated with AFD.VAS score of patients when taking out the stuffing for the first time after 48 h operation and after 72 h operation dressing,the wound hemorrhage score at the end of the operation and when taking out the stuffing for the first time after 48 h operation,and percolation score of wound after 24 h and 48 h operation between the two groups were compared.Results VAS score of patients when taking out the stuffing for the first time after 48 h operation and after 72 h operation dressing in the observation group were significantly lower than those of the control group (P＜0.05).The wound hemorrhage score at the end of the operation and when taking out the stuffing for the first time after 48 h operation in the observation group were significantly lower than those of the control group (P＜0.05).Percolation score of wound after 24 h and 48 h operation in the observation group were significantly lower than those of the control group(P＜0.05).Conclusion Stuffing the wound with AFD in patients after complex anal fistula operation can significantly improve the postoperative pain,reduce the incision hemorrhage rate,and relieve the bleeding and infiltration of the wound,which is suitable for clinical promotion and application.
2018 Vol. 25 (1): 41-43 [Abstract] ( 141 ) HTML (28 KB)  PDF  (0 KB)  ( 36 )
44 Effect observation of respiratory exercise,muscle strength exercise combined with bronchial diastolic drug treating moderate-severe chronic obstructive pulmonary disease
CHEN Su-ting
Objective To observe the effect of respiratory exercise,muscle strength exercise combined with bronchial diastolic drug treating moderate-severe chronic obstructive pulmonary disease.Methods From February 2016 to April 2017,77 patients with moderate-severe chronic obstructive pulmonary disease treated in our hospital were selected.In the reference group,33 patients were treated by aerosol inhalation of bronchial diastolic drug.In the research group,44 patients were given the respiratory exercise and muscle strength exercise on the basis of the reference group.The clinical effect between the two groups was compared.Results After treatment,the total effective rate was 93.2%and the score of life quality was (95.41±1.23)points in the research group while in the reference group,it was 72.7%and(86.92±7.42)points respectively,and there was a statistical difference of above-mentioned indexes between the two groups (P＜0.05).The improvement degree of FEV1%pred,PaCO2and PaO2in the research group were better than those in the reference group(P＜0.05).Conclusion For patients with moderate-severe chronic obstructive pulmonary diseases,application of bronchial diastolic drug,respiratoryexercise,and muscle strength exercise is of great significance on improvement of pulmonary function as well as the life quality.
2018 Vol. 25 (1): 44-46 [Abstract] ( 162 ) HTML (29 KB)  PDF  (0 KB)  ( 43 )
47 Effect on diabetes mellitus and cardio-cerebrovascular events by comprehensive intervention in the community people of pre-diabetes
ZHOU Zu-yong;LlANG Jin-hua;WU Yu-dong;ZHANG Yan-Li; MAI Hai-yuan;ZHOU Hong-hui
Objective To investigate the effect on diabetes mellitus and cardio-cerebrovascular events by comprehensive intervention in the community people of pre-diabetes.Methods In October 2013,people diagnosed with pre-diabetes in the six communities(randomly selected from the 12 communities that had been surveyed for chronic disease control)of community health service center in our hospital were selected as subjects,a total of 712 cases.Three communities(366 cases)in the six were randomly selected as the enhanced intervention group,and the other three communities(346 cases)were selected as the control group.The intervention group was treated with enhanced intervention,and the control group was treated with routine treatment.The fasting blood glucose,postprandial blood glucose,triacylglycerol,cholesterol,waist circumference,hip circumference and blood pressure were compared before and after the intervention of the two groups,and the incidence of cardio-cerebrovascular disease of the two groups were compared.Results Before intervention,the waist circumference,hip circumference,blood glucose,systolic blood pressure,cholesterol and triacylglycerol were compared in the two groups,the differences were not statistically significant(P＞0.05).After intervention,the waist circumference,fasting blood glucose,postprandial blood glucose,cholesterol and systolic blood pressure of the enhanced intervention group were significantly lower than those of before intervention,the differences were statistically significant(P＜0.05).The fasting blood glucose,postprandial blood glucose and systolic blood pressure of the control group were significantly higher than those of before intervention,the differences were statistically significant(P＜0.05).After intervention,the waist circumference,fasting blood glucose,postprandial blood glucose,systolic blood pressure,cholesterol and triacylglycerol of the enhanced intervention group were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The incidence of progress from pre-diabetes to diabetes of the enhanced intervention group (9.02%)was significantly lower than that in the control group(16.47%),the difference was statistically significant(χ2=10.73,P＜0.01).The total incidence of cardio-cerebrovascular events of the enhanced intervention group (3.28%)was significantly lower than that in the control group (7.80%),the difference was statistically significant(χ2=6.33,P=0.012).Conclusion Targeted community comprehensive intervention is more effective to prevent or delay of progress from pre-diabetes to diabetes than conventional treatment,and to reduce the incidence of cardio-cerebrovascular events in the people of pre-diabetes,too.So it can provide a new strategy for the prevention of cardio-cerebrovascular diseases.
2018 Vol. 25 (1): 47-50 [Abstract] ( 142 ) HTML (37 KB)  PDF  (0 KB)  ( 40 )
51 Effect of Irbesartan combined with conventional therapy on left ventricular hypertrophy and heart rate variability in patients with hypertension
LIU Da-liang;OU Xing-mian
Objective To investigate the effect of Irbesartan combined with conventional therapy on left ventricular hypertrophy and heart rate variability in patients with hypertension.Methods 80 patients with hypertension treated in our hospital from January 2015 to December 2016 were selected as subjects and divided into two groups according to the random number table method,40 patients in each group.The patients in the control group were treated with conventional therapy,patients in the study group were given Irbesartan combined with conventional therapy.The blood pressure,left ventricular structure indexs and heart rate variability indexs were compared between the two groups before and after intervention.Results After intervention,the systolic and diastolic pressure of the study group were significantly lower than those of the control group,the differences were statistical significance (P＜0.05).The left ventricular correlation indexs of the study group were significantly lower than those of the control group,the differences were statistical significance(P＜0.05).The indexes of SDANN,SDNN,rMSSD,PNN50 and HF in the study group were significantly higher than those in the control group,and the LF and LF/HF were lower than those in the control group,the differences were statistical significance (P＜0.05).Conclusion In the treatment of patients with hypertension in the choice of Irbesartan combined with routine treatment can significantly reduce the blood pressure,improve patients with left ventricular structure and heart rate variability,it is worth popularizing in clinical use.
2018 Vol. 25 (1): 51-53 [Abstract] ( 171 ) HTML (31 KB)  PDF  (0 KB)  ( 36 )
54 Comparison of the effects of Benazepril and Metoprolol in the treatment of elderly patients with essential hypertension and heart failure
LAI Mu-qiao;HUANG Fei-xiong;WU Xiao-feng
Objective To investigate the clinical effects of Benazepril and Metoprolol in the treatment of elderly patients with essential hypertension and heart failure.Methods 90 elderly patients with essential hypertension and heart failure who treated in our hospital from February 2014 to December 2016 were selected as subjects.They were randomly divided into three groups,each group with 30 cases.The patients in the control group 1 were treated with Benazepril,the patients in the control group 2 were treated with Metoprolol,and the patients in the study group were treated with Benazepril combined with Metoprolol.The clinical efficacy,blood pressure,heart rate and indexs of cardiac function of the three groups were compared.Results The total effective rate of clinical treatment in the study group (96.67%)was significantly higher than that in the control group 1 (76.67%)and the control group 2 (73.33%),and the differences were statistically significant(P＜0.05).After intervention,the blood pressure and heart rate of the patients in the study group were lower than that of the control group 1 and the control group 2,and the differences were statistically significant(P＜0.05).After intervention,the levels of LVESD and LVEDD in the study group were significantly lower than those in the control group 1 and the control group 2,the levels of LVEF and 6MWT were higher than those of the control group 1 and the control group 2,and the differences were statistically significant(P＜0.05).Conclusion In the treatment of elderly patients with essential hypertension and heart failure,Benazepril combined with Metoprolol treatment can significantly improve the treatment effect,not only a good pressure control effect can also improve the patients′cardiac function,worthy of clinical use.
2018 Vol. 25 (1): 54-56转60 [Abstract] ( 194 ) HTML (32 KB)  PDF  (0 KB)  ( 33 )
57 Randomized controlled trial of treatment with low-frequency repetitive transcranial magnetic stimulation for patients with primary insomnia
YUAN Jun-mei;LI Xue-xin;XU Yao-kun;SU Feng-ling;WANG Ning;GUO Tong
Objective To investigate the efficacy of low-frequency repetitive transcranial magnetic stimulation(rTMS)for patients with primary insomnia.Methods 60 patients were diagnosed with"primary insomnia"who were treated in the psychiatric department of veterans hospital in Liaocheng city from November 2015 to November 2016 were selected as subjects.The random number table method was used to divide them into treatment group and control group,30 cases in each group.The patients in the treatment group were treated with rTMS,the patients in the control group were given fake stimulus for treamnet,which were treated 5 times a week,20 min each time,20 times in total.The PSQI scores before and after 2,4 weeks of treatment,the total efficiency of treatment and adverse reactions were compared between the two groups.Results Before treatment,the PSQI score was compared in both groups,and the difference was not statistically significant(P＞0.05).After 2 and 4 weeks of treatment,the PSQI scores of both groups were lower than before treatment,the PSQI scores in the treatment group were significantly lower than those in the control group,the differences were statistically significant(P＜0.01).The total treatment efficiency of patoients in the treatment group(96.7%)was higher than taht in the control group (26.7%),the difference was statistically significant(P＜0.01).The adverse reactions in the two groups were compared,and the difference was not statistically significant(P＞0.05).Conclusion The rTMS which is painless,non-invasive,cost-effective and safe may help to improve insomnia without increase of the adverse events.
2018 Vol. 25 (1): 57-60 [Abstract] ( 146 ) HTML (35 KB)  PDF  (0 KB)  ( 31 )
61 Clinical effect of minimally invasive therapy of small bone window in the treatment of hypertension-induced cerebral hemorrhage
ZHANG Rui-jian;HAN Zhi-tong;CHEN Yun-zhao;ZHAO Wei-ping;ZHANG Yi-song
Objective To investigate the clinical effect of small bone window in the treatment of hypertension-induced cerebral hemorrhage.Methods From January 20,2016 to January 20,2017,100 patients with hypertension-induced cerebral hemorrhage who treated in our hospital were selected as subjects.They were randomly divided into observation group and control group,50 cases in each group.In the observation group,minimally invasive therapy of small bone window was applied,while in the control group,traditional craniotomy for evacuation of hematoma was provided.The treatment effect,complication rate and scores of life quality of the two groups were compared.Results The total effective treatment rate in the observation group(98.00%)was higher than that in the control group(78.00%),and the difference was statistically significant(P＜0.05).The incidence of complications in the observation group (2.00%)was lower than that in the control group(20.00%),and the difference was statistically significant(P＜0.05).The scores of body function,social function,psychological function and material life of the patients in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Application of small bone window as a minimal invasion in the treatment of patients with hypertension-induced cerebral hemorrhage,the effect is remarkable in high safety,can effectively improve the quality of life scores,which is worthy of clinical promotion.
2018 Vol. 25 (1): 61-63 [Abstract] ( 162 ) HTML (28 KB)  PDF  (0 KB)  ( 34 )
64 Rehabilitation application study of regular return visit to patients with spinal injury after discharge
LI Fang;LIN Gao-ping;ZENG Jin-feng;OUYANG Qin
Objective To explore the rehabilitation application effect of regular return visit to patients with spinal injury after hospital discharge.Methods From March 2016 and March 2017,the clinical data of 88 patients with spinal injury after discharge in our hospital were retrospectively analyzed.According to whether the regular return visit,they were evenly divided into the control group and the research group,44 cases in each group.In the control group,no regular return visit was used,while in the research group,regular return visit was adopted.The scores of physical function and psychological status,complications,recurrence,and awareness of rehabilitation knowledge by patients and their families before and after visits were compared between the two groups.Results Before return visit,there was no great difference in scores of physical function or psychological status between the two groups(P＞0.05).The FMA score after return visit in the research group was much higher than that in the control group(P＜0.05).The scores of SDS and SAS in the research group were greatly lower than those in the control group (P＜0.05).The incidence rate of complications and recurrence rate in the research group were greatly lower than those in the control group(P＜0.05).The qualified rate of understanding rehabilitation knowledge by patients and their families in the research group was obviously lower than that in the control group (P＜0.05).ConclusionRegular return visit after hospital discharge for patients with spine injury can improve the physical function and psychological status,and reduce the incidence rate of complications and recurrence.
2018 Vol. 25 (1): 64-66 [Abstract] ( 146 ) HTML (30 KB)  PDF  (0 KB)  ( 29 )
67 Clinical effect analysis of antecubital brachial artery and median nerve approach in the treatment of ulna coracoid process fracture
WANG Xian-fang;LIU Zhang-sheng;LIU Chuan-lin
Objective To explore the clinical effect of antecubital brachial artery and median nerve approach in the treatment of patients with ulna coracoid process fracture.Methods 42 patients with ulna coracoid process fracture treated in our hospital from April 2015 to April 2017 were enrolled as research objects.According to the random number table method,they were evenly divided into the control group(21 cases)and the observation group(21 cases).The control group was treated medial approach,and the observation group was treated with antecubital brachial artery and median nerve approach.The therapeutic effectiveness rate,operation time,intraoperative amount of bleeding,postoperative volume of drainage,healing time of bone fracture,and the incidence of complications were compared between the two groups.Results The therapeutic effectiveness rate in the observation group was 95.23%,which was higher than that in the control group accounting for 71.43%,with a statistical difference(P＜0.05).The indexes of operation time,healing time of bone fracture in the observation group was shorter than that in the control group,intraoperative amount of bleeding,postoperative volume of drainage in the observation group was less than that in the control group,with statistical differences(P＜0.05).The incidence rate of postoperative complications in the observation group was 4.76%,which was significantly lower than that in the control group accounting for 28.57%,which was displayed a statistical difference(P＜0.05).Conclusion For patients with ulna coracoid process fractures,application of antecubital brachial artery and median nerve approach can obtain a remarkable effect by greatly increasing the cure rate and reducing the clinical adverse reaction,which is worthy of promotion.
2018 Vol. 25 (1): 67-69 [Abstract] ( 151 ) HTML (30 KB)  PDF  (0 KB)  ( 27 )
70 Clinical effectiveness of closed reduction and internal fixation with PFNA combined with Huayu Jiegu Decoction in the treatment of senile femoral intertrochanteric fracture
WANG Yang
Objective To investigate the clinical effect of closed reduction and internal fixation with PFNA combined with Huayu Jiegu Decoction in the treatment of senile femoral intertrochanteric fracture.Methods Altogether 130 cases of elderly patients with femoral intertrochanteric fracture who were treated in our hospital from August 2012 to June 2016 were selected as the research object,and randomly divided into the control group and the study group according to the simple averaging method,with 65 cases in each group.The control group was given conventional surgery,the study group was given oral Huayu Jiegu Decoction on the basis of routine surgery.The fracture healing situation of the two groups was observed by using X-ray film postoperatively,and the fracture healing days of the two groups were recorded.The hip joint function status was evaluated at postoperative 3 months by using the Harris hip score standard.Results The excellent rate of the study group was higher than that of the control group,with statistically significant difference(P＜0.05).The clinical healing days of the study group was less than that of the control group,with statistically significant difference(P＜0.05).At postoperative 3 months,the hip joint function score of the study group was higher than that of the control group,with statistically significant difference(P＜0.05).The score of callus growth of the study group was higher than that of the control group at postoperative 2 and 3 months,with significant difference(P＜0.05).Conclusion Application of closed reduction and internal fixation with PFNA combined with Huayu Jiegu Decoction has the features of short healing time,high hip joint function score and high excellent rate in the treatment of senile femoral intertrochanteric fracture,which is worthy of popularization and application in primary hospitals.
2018 Vol. 25 (1): 70-72转75 [Abstract] ( 174 ) HTML (31 KB)  PDF  (0 KB)  ( 31 )
73 Effect of double Kirschner wire antegrade intramedullary fixation in the treatment of fifth metacarpal neck fracture
GONG Jun;QIU Chuan-jun;ZHANG Yue-lin

Objective To investigate the effect of double Kirschner wire antegrade intramedullary fixation in the treatment of fifth metacarpal neck fractures.Methods 60 cases of fifth metacarpal neck fracture patients from June 2014 to June 2016 in our hospital were selected,according to different treatment methods,they were divided into the observation group(33 cases)and the control group(27 cases).The observation group was treated with double Kirschner wire and antegrade intramedullary fixation,and the control group was treated with micro condylar plate and screw fixation.The average operative time,fracture healing time and hand function recovery of the two groups of fracture patients were recorded and compared.Results The average operation time of the observation group was(19.0±3.1)min,which was shorter than that of the control group ([48.0±2.6]min),and the difference between the two groups was significant(P＜0.05).There was no significant difference in the time of fracture healing between the two groups(P＞0.05).According to the TAM standard for evaluation assessment,there was no significant difference in the recovery of hand function between the two groups(P＞0.05).Conclusion Using Kirschner needle operation method in the treatment of the fifth metacarpal neck fracture in patients has little trauma and short operative time for patients,it can promote early recovery of patients.Micro condyle plate and internal fixation is a better treatment for comminuted metacarpal neck fracture.
2018 Vol. 25 (1): 73-75 [Abstract] ( 135 ) HTML (27 KB)  PDF  (0 KB)  ( 37 )
76 Effect comparison of pedicle screw fixation and general spinal internal fixation in the treatment of thoracolumbar spine fracture
PENG Chuan-hua;CHEN Jian
Objective To analyze the effect of different internal fixation methods in the treatment of thoracolumbar spinal fractures,and to provide a reference for the selection of specific surgical methods in clinical practice.Methods The clinical data of 61 patients with thoracolumbar spinal fractures treated in our hospital from January 2014 to January 2017 were retrospectively analyzed,and all patients were treated with single segment fixation,bone graft and fusion.According to the different methods of internal fixation,61 patients were divided into the control group(30 cases)and the observation group (31 cases).The control group was treated with pedicle screw fixation,and the observation group was treated with general spinal internal fixation.The curative effect and the incidence rate of complication between the two groups were compared,and the amount of bleeding and the operation time of the patients were compared.Results There was no significant difference in the height of the Cobb angle,the posterior edge and the front edge of the vertebral body between the two groups of patients(P＞0.05).The amount of bleeding in the observation group was less than that of the control group,and the operation time in the observation group was shorter than that in the control group,with significant difference (P＜0.05).The incidence rate of complications in the observation group was 0.00%,which was lower than that in the control group(13.33%),with significant difference(P＜0.05).Conclusion Compared with pedicle screw fixation,the use of general spinal fixation for pedicle screw fixation can significantly reduce the amount of intraoperative blood loss and shorten the operation time,and less complications and adverse reactions,high safety,therefore,in clinical practice,the general spinal internal fixation is the first choice for the treatment of thoracolumbar spine fracture with single segmental fixation and bone graft fusion.
2018 Vol. 25 (1): 76-78 [Abstract] ( 146 ) HTML (30 KB)  PDF  (0 KB)  ( 32 )
79 Effect observation of hip arthroplasty in the treatment of displaced femoral neck fracture in elderly patients
GUO Wen-long
Objective To investigate the effect of hip arthroplasty(HA)and internal fixation(IF)in the treatment of displaced femoral neck fracture in elderly patients.Methods 65 cases of elderly patients with femoral neck fracture were selected as the subjects,who were hospitalized in our hospital from July 2010 to January 2015.They were divided into the HA group(31 cases)and the IF group(34 cases)according to different treatment methods.The patients in the IF group were treated with IF,and the patients in the HA group were treated with HA.The intraoperative blood loss,duration of operation,length of hospital stay,incidence of postoperative complication and reoperation rate in the two groups were recorded.The hip function of the two groups was compared in the first,second years after operation.Results Compared with the HA group,the IF group patients had less intraoperative bleeding,shorter operation time and shorter hospitalization time,and the difference between the two groups was statistically significant(P＜0.05).The long term postoperative complication rate was 26.5%in the IF group and was 9.7%in the HA group,the reoperation rate was 23.5%in the IF group and was 6.5%in the HA group,the difference between the two groups was statistically significant(P＜0.05).The excellent and good rate of hip joint function in the HA group was better than that in the IF group,the difference between the two groups was statistically significant(P＜0.05).Conclusion The long-term clinical effect of HA in the treatment of displaced femoral neck fracture in elderly patients is better than that of internal fixation and it is worthy of clinical promotion.
2018 Vol. 25 (1): 79-81 [Abstract] ( 162 ) HTML (29 KB)  PDF  (0 KB)  ( 26 )
82 Study on the value of Notch 3 in the early stage of premature infants with early diagnosis of bronchopulmonary dysplasia
CHEN Ying;ZHANG Jin-feng; MAI Li-shan;ZHANG Li-xia;ZENG Li-jun;LU Zhen-qi
Objective To investigate the value of Notch 3 in the blood of preterm infants in the early diagnosis of bronchopulmonary dysplasia (BPD).MethodsA total of 78 patients with gestational age of 27 to 32 weeks received in Maternal and Child Health Hospital of Foshan City from January 2016 to February 2017 were recorded.There were 23 patients with BPD and 55%of non-BPD children.The BPD group was set as the observation group,and the children who had not been diagnosed with BPD were matched with the gestational age of BPD group in the neonatal department.The expression of Notch 3 in the two groups was measured.Results The values of Notch 3 in the observation group were significantly higher than those in the control group,and the difference between the observation group and the control group was statistically significant(P＜0.05).Conclusion Notch 3 is highly expressed in the pathogenesis of BPD,and Notch 3 has a high early diagnostic value for BPD.
2018 Vol. 25 (1): 82-84 [Abstract] ( 145 ) HTML (28 KB)  PDF  (0 KB)  ( 31 )
85 The clinical application value of yoga exercise in pregnant women
SHAO Yan-ling;HE Nuan-hong
Objective To analyze the clinical application value of yoga exercise in pregnant women,and to provide guidance for clinical practice.Methods From January to June in 2016,100 pregnant women were selected as target objects in this experiment in our hospital.By a random number table method,these participants were evenly divided into the control group and the experimental group,50 cases in each group.In the control group,routine prenatal care was used from week 16 of gestation to delivery,while in the experimental group,on the basis of the routine prenatal care,yoga exercise was added during the same time.The body mass index(BMI),stages of labor,deliverymode,and maternal and child outcomes in the two groups were analyzed and compared.Results There was no significant difference in the BMI or the third stage of labor between the two groups before intervention(P＞0.05).Before delivery,theBMI,time of the first and second stages of labor,and time of total stage of labor were displayed statistical differences between the two groups(P＜0.05）.The vaginal delivery rate was 84.00%in the experimental group,higher than that in the control group accounting for 46.00%,with a statistical difference(P＜0.05）.In the experimental group,incidence of gestational diabetes mellitus,gestational hypertension,neonatalasphyxia,and fetal distress was 2.00%,6.00%,2.00%,and 6.00%,much lower than those in the control group,18.00%,26.00%,20.00%,and 24.00%accordingly,which were displayed statistical differences(P＜0.05）.There was no great difference in the incidence of premature rupture of fetal membranes,6.00%and 12.00%in the experimental group and control group respectively(P＞0.05）.Conclusion Yoga exercise for pregnant women can effectively control the weight,shorten the labor,increase vaginal delivery rate,anddecrease the incidence of gestational diabetes mellitus,gestational hypertension,and fetal distress,which is helpful to ensure the safety of newborns.
2018 Vol. 25 (1): 85-87 [Abstract] ( 117 ) HTML (28 KB)  PDF  (0 KB)  ( 40 )
88 Effect of peripheral blood TSH，FT4and FT3levels on maternal and child birth outcomes in pregnant women less than 20 weeks of pregnancy
CHANG Li-ping
Objective To investigate the relationship between early pregnancy maternal serum thyrotropin(TSH),free triiodothyronine(FT3),free thyroxine(FT4)levels and maternal birth outcomes,in order to study the effect of maternal birth outcomes.Methods From February 2015 to February 2017,250 cases in our hospital obstetrics were collected according to screening results of the thyroid function and divided into 80 cases in thyroid abnormalities groups(24 cases of clinical hypothyroidism and 56 cases of subclinical hypothyroidism),66 cases in the treatment groups(22 cases of clinical hypothyroidism and 44 cases of subclinical hypothyroidism)and 104 cases of normal thyroid function as the control group.TSH,FT3,FT4level were detected among all subjects.At the 12 weeks of pregnancy,treatment group underwent levothyroxine(L-T4)treatment,and TSH,FT3and FT4levels were close monitoring until delivery,when the levels of TSH,FT3and FT4in each group in different times as well as neonatal and maternal outcomes were compared.Results Compared with the control group,the differences of TSH,FT3and FT4levels in the clinical hypothyroidism group and subclinical hypothyroidism groups were statistically significant(P＜0.05),adverse neonatal outcomes rate in hypothyroidism and subclinical hypothyroidism treatment groups were significantly lower than abnormalities groups after symptomatic treatment,treatment of subclinical hypothyroidism group had lower incidence rate of maternal complications than abnormalities subclinical hypothyroidism group,the differences were statistically significant(P＜0.05).Conclusion Early pregnancy joint detection in TSH,FT3,FT4level can figure out the abnormal thyroid function timely and accurately,which can effectively improve the security of delivery under the timely diagnosis and early treatment.
2018 Vol. 25 (1): 88-91 [Abstract] ( 149 ) HTML (36 KB)  PDF  (0 KB)  ( 29 )
92 A comparative contraceptive effect among different contraceptive actions after cesarean scar pregnancy curettage
YANG Cai-hong;LI Yong-da
Objective To explore the contraceptive efficacy and safety of compound short-acting oral contraceptives,levonorgestrel releasing intrauterine system and condoms after cesarean scar pregnancy curettage.Methods From August 2014 to August 2016,121 patients with cesarean scar pregnancy were randomized into three groups.39 patients in the contraceptive pill group were treated with compound short-acting contraceptives,39 patients in mirena group were placed Mirena (levonorgestrel-releasing intrauterine system)after curettage immediately,and 43 patients in condom group were given condoms contraception.Patients of three groups were followed up to compare ultrasonic examination results,unexpected pregnancy and menstrual flow change.Results Patients were followed up for 12 months.The total effective rates of patients in contraceptive pill group was 97.4%,there was 1 case of recurrent CSP in contraceptive pills group because of forget to take the pills.The total effective rates of patients in Mirena patient group was 100%.The total effective rates of patients in condoms contraception group was 91%.There was 4 pregnancy occurred,including 1 case of recurrent CSP and 3 case of intrauterine pregnancy.The total effective rates of patients in contraceptive pill group and Mirena patient group were significantly higher than patients in condoms contraception group,and the difference was statistically significant(P＜0.05).Ultrasonic examination showed there were no incision rupture or damage and no complaints about asexual life in the 3 groups.There was no increase in the amount of menstruation in the three groups and the decrease of menstruation in the patients of Mirena group was significantly higher than that of the condom group and the contraceptive pill group at 3,6 and 12 months postoperatively,with significant difference (P＜0.05).ConclusionAfter uterine artery embolization combined with uterine curettage cesarean scar pregnancy patients can take marvelon and Mirena intrauterine contraception,which is safe,reliable,and can benefit patients more,and is better than only using condoms.
2018 Vol. 25 (1): 92-94 [Abstract] ( 132 ) HTML (29 KB)  PDF  (0 KB)  ( 37 )
95 Vaginal delivery after cesarean section without vaginal delivery
WEN Jie-hong;CHEN Lin
Objective To explore the safety of vaginal delivery after cesarean section without vaginal delivery.Methods The clinical data of 128 cases pregnant women(study group)without vaginal delivery after cesarean section and 130 cases pregnant women(control group)who conformed to the standard of vaginal delivery in our hospital from April 2015 to April 2017 were retrospectively analyzed.The vaginal delivery success rate,vaginal delivery course,rate of rupture of uterus,postpartum hemorrhage and neonatal condition were compared between the two groups.Results The vaginal delivery success rate of the study group was slightly lower than the control group,but no statistic difference(P＞0.05).There was no statistic difference in the first stage,the second stage,the third stage and the total stage of labor between two groups(P＞0.05).The 2 and 24 h postpartum hemorrhage of the study group were significantly higher than the control group,the difference was statistically significant(P＜0.05).There was no statistic difference in neonatal weight,score and asphyxia between two groups(P＞0.05).Conclusion The pregnant women without vaginal delivery after cesarean section could be recommended to try vaginal labor under strict screening and close monitoring.
2018 Vol. 25 (1): 95-97 [Abstract] ( 125 ) HTML (29 KB)  PDF  (0 KB)  ( 35 )
98 Analysis of indicators of tidal volume mechanical ventilation in children with acute lung injury/acute respiratory distress syndrome
TIAN Xing-guo
Objective To study the effect of different tidal volume ventilation strategies on the prognosis of children with acute lung injury/acute respiratory distress syndrome.Methods 94 children with acute lung injury/acute respiratory distress syndrome were enrolled in our hospital.All subjects were enrolled from July 2015 to July 2017,and random numbers were used.The patients were divided into the study group and the control group,47 cases in each group.The control group of children were treated with 10-12 ml/kg tidal volume for mechanical ventilation,the observation group of children were treated with 6-8 ml/kg tidal volume.The plasma ventilation time,mortality,survival time,hospitalization time and the incidence of adverse reactions were compared between the two groups.ResultsAfter 4 days of ventilation,the levels of pH,PaCO2and PaO2in the two groups were better than those in the initial ventilation(P＜0.05).After 4 days of ventilation,ventilation,pH、PaCO2、PaO2and the incidence of adverse reactions was no significant difference between the two groups(P＞0.05).The plasma ventilation time,mortality,survival time,hospitalization time in the study group lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The effect of mall tidal volume ventilation strategy in acute lung injury/acute respiratory distress syndrome in children is better,should be recommended.
2018 Vol. 25 (1): 98-100 [Abstract] ( 135 ) HTML (29 KB)  PDF  (0 KB)  ( 31 )
101 Effect of Yanhuoning on the treatment of mycoplasma pneumonia in children and its effects on immune function
WANG Gang
Objective To investigate the effect of Yanhuning on the treatment of mycoplasma pneumonia in children and its immune function.Methods A total of 96 children with mycoplasma pneumonia were selected from January 2014 to July 2016.The patients were randomly divided into experimental group and reference group,each group was 48 patients.The experimental group was given Azithromycin combined with Yanhuning,and the reference group was treated with azithromycin.The clinical efficacy,therapeutic efficiency and changes of cellular immune parameters after treatment were compared between the two groups.Results After treatment,the effective rate of treatment in the experimental group was 93.75%,which was significantly higher than that of the reference group(79.17%),the difference was statistically significant(P＜0.05).There was no significant difference in immunoglobulin M(IgM),immunoglobulin G(IgG)and immunoglobulin A(IgA)between the two groups before treatment(P＞0.05).IgM,IgG and IgA levels in both groups were significantly lower than those before treatment(P＜0.05）.The level of IgM and IgG were significantly lower in both groups(P＜0.05).Conclusion The use of Yanhuning adjuvant treatment of children with mycoplasma pneumonia has a significant clinical efficacy,can improve the efficiency of treatment in children,improve the humoral immune function in children,in clinical treatment worthy of promotion and application.
2018 Vol. 25 (1): 101-103 [Abstract] ( 131 ) HTML (27 KB)  PDF  (0 KB)  ( 21 )
104 Risk factors of retinopathy of prematurity requiring treatment
YE Zheng-wei;ZHENG Yi;PEN Li;MAO Jin ;ZHOU Hong;JIANG Yan
Objective To investigate the risk factors of retinopathy of prematurity(ROP)requiring treatment.Methods To exclude infants of multiple malformations,to run a retrospective study of all the infants diagnosed with ROP from March 2014 to February 2015 in our hospital.They were divided into ROP treated group （16 cases） and non-treatment group（28 cases）.ROP treated group included：ROP 4 or 5 periods,Ⅰ type pre-threshold disease and the threshold disease.The rest are non-treatment group.The relationship between various clinical risk factors and the ROP requiring treatment were considered by t-test,X2-test and multiple logistic regression analysis,and those risk factors includes gestational age,birth weight,gender,oxygen time,suffocation,blood transfusion,multiple births,sepsis,mode of delivery.Results A total of 44 cases diagnosed with ROP,16 cases were included in treated group(36.36%),and the other 28 cases were untreated(63.64%).Gestational age,blood transfusion and normal delivery had something to do with the occurrence of ROP requiring treatment.Conclusion Gestational age,blood transfusion and vaginal delivery are the risk factors of ROP requiring treatment.
2018 Vol. 25 (1): 104-106 [Abstract] ( 150 ) HTML (29 KB)  PDF  (0 KB)  ( 28 )
107 Clinical effect of laparoscopic in the treatment of ectopic pregnancy
SHEN Jian-hua
Objective To analyze the clinical application effect of laparoscopic surgery for patients with ectopic pregnancy.MethodsThe clinical data of 70 cases of patients with ectopic pregnancy treated in our hospital from July 2014 to July 2015 were retrospectively analyzed.All patients were given the surgical treatment to terminate the pregnancy,of which 45 cases treated with laparoscopic surgery were selected as the study group and 25 cases treated with laparotomy were enrolled in the control group.The incision size,operative time,intraoperative blood loss,hospital stay,catheter retention time,the time of first getting out of bed and the postoperative complications were recorded between the two groups,and the operative effect was evaluated.After 2 years of follow-up,the pregnancy condition (intrauterine pregnancy,ectopic pregnancy)and fallopian tube recanalization rate were recorded in the two groups.Results①The two groups were successfully completed the operation and the success rate was 100%.The levels of incision size,operative time,intraoperative blood loss,hospital stay,catheter retention time,the first time to get out of bed and the postoperative complications in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).②Follow-up results showed that the intrauterine pregnancy rate in the study group was significantly higher than that in the control group while the ectopic pregnancy rate was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Laparoscopic surgery is a minimally invasive surgery with small trauma and can reduce the interference to the physiological function.Little intraoperative blood loss,short postoperative hospital stay and few complications in patients can greatly improve the intrauterine pregnancy rate,therefore it is worthy of the promotion for patients with ectopic pregnancy but without laparoscopic surgery contraindications.
2018 Vol. 25 (1): 107-109 [Abstract] ( 143 ) HTML (28 KB)  PDF  (0 KB)  ( 39 )
110 Observation on the clinical application of cervical dilatation balloon in promoting cervical maturity and induction of labor in full-term pregnancy
JIN Zhi;YANG Jian-en;HUANG Yan-li;CHEN Li-xia;WANG Nai-ping;GUO Dong-qin
Objective To investigate the clinical effect of cervical dilatation balloon in promoting cervical maturity and induction of labor in full-term pregnancy.Methods From January 2015 to January 2017,200 cases of full-term pregnant women with indications of induction of labor and cervical score＜6 who were admitted to our hospital were selected as the observation subjects.According to the methods of induction of labor,the patients were divided into two groups,100 cases in each group.The control group were given oxytocin for labor induction,and in the observation group were given cervical dilatation balloon for labor induction.The clinical effect and the duration of induction of labor to childbirth were observed in both groups.Results There were significant differences in the clinical effects between the observation groups and the control group(P＜0.05),with statistical significance;the duration of induction of labor to childbirth,and maternal postpartum hemorrhage in the observation were significantly lower than that in the control group,and the 5 min neonatal Apgar score was significantly higher than that in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in neonatal body mass index between the two groups(P＞0.05).Conclusion The clinical effect of cervical dilatation balloon for full-term pregnancy promoting cervical maturity and induction of labor is more significant,safe and reliable,which is worthy of promotion.
2018 Vol. 25 (1): 110-112 [Abstract] ( 141 ) HTML (28 KB)  PDF  (0 KB)  ( 31 )
113 Clinical efficacy of gonadotropin-releasing hormone agonist combined with add-back therapy for consolidation treatment after the surgery of endometriosis
MI Yi
Objective To study the effect of gonadotropin-releasing hormone agonist(GnRHa)add-back therapy after the surgery of endometriosis.Methods A total of 86 patients with endometriosis who were admitted to the department of gynecology in our hospital from January 2016 to February 2017 were selected as the study subjects.The patients were divided into groups by a complete double-blind method.In the control group,43 patients were given GnRHa treatment，and in the experimental group,43 patients were given GnRHa combined with add-back therapy.The efficacy was evaluated in both groups，and the changes of the levels of serum sex hormones and the occurrence of adverse reactions were observed in both groups.Results①The total effective rate in the experimental group was significantly higher than that in the control group(P＜0.05).②The levels of serum P,LH and FSH in the experimental group were significantly lower than those in the control group，and E2was significantly higher than that in the control group(P＜0.05).③After medication,the two groups showed menopausal symptoms.The incidence rate of hot flashes in the experimental group was significantly lower than that in the control group (P＜0.05)and there was no statistically significant difference in the incidence rate of other symptoms(P＞0.05).Conclusion In the consolidation treatment after the surgery of endometriosis,the curative effect of GnRHa combined with add-back therapy is superior to GnRHa alone,add-back therapy is conducive to stabilizing the level of serum sex hormones,and relieving adverse reactions,which is worthy of being learned from.
2018 Vol. 25 (1): 113-115 [Abstract] ( 119 ) HTML (28 KB)  PDF  (0 KB)  ( 34 )
116 Value of color Doppler ultrasound in the diagnosis of senile degenerative heart valvular disease
HE Wei-ming;LI Shao-jun
Objective To study and explore the value of color Doppler ultrasound in the diagnosis of senile degenerative heart valvular disease(SDHVD).Methods From March 2013 to July 2017,130 elderly patients with suspected SDHVD in our hospital were selected as research objects.All patients were examined by color Doppler ultrasound.With reference to clinical comprehensive diagnostic results,the diagnostic sensitivity,specificity，and accuracy of color Doppler ultrasound for SDHVD were calculated.The consistency between the diagnostic results of color Doppler ultrasound and clinical diagnosis was analyzed,and the diagnostic coincidence rate of SDHVD in different types was statistically analyzed.Results The sensitivity,specificity,and accuracy of color Doppler ultrasound in the diagnosis of SDHVD were 94.23%,96.15%,and 94.61%,respectively,which proved a great consistence between the diagnostic results of color Doppler ultrasound and clinical diagnosis(Kappa=0.735).The diagnostic accordance rates of color Doppler ultrasound in aortic valve calcification,mitral valve calcification,and combined valve calcification were 96.23%,96.43%,and 100.00%respectively.Conclusion In the clinical diagnosis of SDHVD,color Doppler ultrasound diagnosis has a high sensitivity,specificity,and accuracy,can be used to distinguish the different types of valvular heart disease in a relatively high diagnostic value.
2018 Vol. 25 (1): 116-118 [Abstract] ( 129 ) HTML (27 KB)  PDF  (0 KB)  ( 36 )
119 Value of respiratory biphasic contrast in thoracic mycobacteria with children
ZENG Qing-hua
Objective To evaluate the clinical value of respiratory biphasic contrast in thoracic mycobacteria with children.Methods 80 children with mycoplasma pneumonia were enrolled from February 2016 to June 2017 and they were randomly divided into observation group and control group,40 cases in each group.The observation group was treated with respiratory biphasic chest radiography.The control group was treated with routine chest radiography.Then the two group of chest radiographs showed with the main indexes of lesion morphology,density and lung texture and diagnosed rate were compared.Results The scores of the lesion grade with observation group was significantly lower than those before and control group after intervention(P＜0.05),the score of lung-marking in the observation group was significantly lower than those before and control group after intervention (P＜0.05),the diagnostic rate with the observation group was significantly higher than that the control group,the differences were statistically significant(P＜0.05).Conclusion For children with mycoplasma pneumonia to use breathing biphasic contrast chest radiography can better access to lung lesions morphology,density and changes in lung texture,so it can improve diagnostic efficiency.
2018 Vol. 25 (1): 119-121 [Abstract] ( 124 ) HTML (29 KB)  PDF  (0 KB)  ( 30 )
122 Analysis and evaluation the rational use of second psychotropic drugs in wards
ZHANG Jing-shuang;GUO Mei
Objective To investigate the use status of second psychotropic drugs in our hospital and evaluate the rationality of its clinical use.Methods The frequency of drug use(DDDs)and drug utilization index(DUI)as the index,combined with the basic information of patients(including age,gender,diagnosis,liver and kidney function and so on),the use of second psychotropic drugs of our hospital in July 2017 were counted and analyzed.Results The second psychotropic drugs with high use frequency were Clonazepam Tablets,Lorazepam Tablets and Oxazepam Tablets,the DUI value of Oxazepam Tablets was significantly greater than 1.0,the DUI values of the 10 other second psychotropic drugs were less than or equal to 1.0.Conclusion The use of second psychotropic drugs in our ward is basically reasonable,but some varieties have abuse.So we need to further strengthen the management and realize the standardization of its clinical use.
2018 Vol. 25 (1): 122-124转128 [Abstract] ( 134 ) HTML (31 KB)  PDF  (0 KB)  ( 36 )
125 Effect observation of Levosimendan combined with Levocarnitine in the treatment of patients with refractory heart failure
BAI Qiao-yan;LI Wei;NI Chun-mei;YANG Xiao-mei;DONG Nan;HAN Li-ying;LI Yan-hui;WANG Feng-gong
Objective To investigate the clinical effect of Levosimendan combined with Levocarnitine in the treatment of patients with refractory heart failure.Methods From March 2016 to July 2017,60 patients with refractory heart failure treated in our hospital were enrolled as observation subjects.They were randomly divided into observation group and control group by a random number table method,30 cases in each group.The two groups were provided with routine therapeutic measures such as ECG monitoring,oxygen therapy,diuretic,and angiotensin converting enzyme inhibitor and so forth.In the control group,only Levocarnitine used,while in the observation group,Levosimendan was added on the basis of the control group.The clinical efficacy was observed.Differences of the indicators of left ventricular end diastolic diameter(LVEDd),left ventricular end systolic diameter(LVESd),left ventricular ejection fraction(LVEF)and heart index(CI)by echocardiography (ECG)were observed.The incidence of adverse reactions between the two groups was recorded.ResultsThe total therapeutic effectiveness rate in the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).Before treatment,the LVEDd,LVESd,LVEF and CI of the two groups were compared,and the differences were statistically significan (P＞0.05).After therapy,the values of LVEDd and LVESd in the observation group was significantly higher than those in the control group,and the differences were statistically significan (P＜0.05).The LVEF and CI were greatly lower than those in the control group,and the differences were statistically significan (P＜0.05).The incidence of adverse reactions was 3.33%in the observation group,while the incidence of adverse reactions in the control group was 10.0%,and the incidence of adverse reactions was compared,and the difference was statistically significan (P＞0.05).Conclusion Levosimendan combined with Levocarnitine in the treatment of refractory heart failure can obtain a favorable clinical effect by effectively improving the patients′cardiac function in high safety,which is worthy of promotion in clinical practice.
2018 Vol. 25 (1): 125-128 [Abstract] ( 133 ) HTML (32 KB)  PDF  (0 KB)  ( 41 )
129 Effect evaluation of Ulinastatin intravenous drip in the treatment of severe pneumonia in children
DAI Shang-kang;YU Qia-chao;TAN Yong-hong
Objective To investigate the clinical effect of Ulinastatin intravenous drip in the treatment of severe pneumonia in children.Methods60 children with severe pneumonia treated in our hospital from February 2013 to December 2016 were selected as subjects and divided into control group and study group according to random number method,each group had 30 cases.The patients in the control group received routine treatment,and the patients in the study group were treated with Ulinastatin.The body temperature returned to normal time,white blood cell(WBC)count recovery time,hospitalization time,acute physiology and chronic health evaluation (APACHE-II)and related indexes of lung function and inflammatory stress related indexes of patients in the two groups were compared.Results The body temperature returned to normal time,the WBC count returned to normal time and hospitalization time of patients in the study group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).The score of APACHE-Ⅱof patients in the study group was lower than that of control group,and the difference was statistically significant(P＜0.05).After intervention,the PO2,PaO2/FiO2and lung adaptability of the study group were higher than those in the control group,and P(A-a)O2and respiration rate were lower than those in the control group,and the differences were statistically significant(P＜0.05).After intervention,two groups of patients of IL-1β,TNF-α,CRP,IL-8,PCT levels were significantly lower than before intervention,and the above indices of patients in the study group were significantly lower than the control group,the differences were statistically significant(P＜0.05).Conclusion Ulinastatin intravenous drip can significantly alleviate inflammatory reaction and improve lung function in the treatment of severe pneumonia in children,and has definite clinical efficacy.
2018 Vol. 25 (1): 129-131 [Abstract] ( 123 ) HTML (31 KB)  PDF  (0 KB)  ( 34 )
132 Clinical study of Ginkgo Leaf Extract and Dipyridamole Injection in the treatment of young and middle-aged patients with acute cerebral infarction
ZHANG Tian
Objective To investigate the clinical effect of Ginkgo Leaf Extract and Dipyridamole Injection (GLEDI)in the treatment of young and middle-aged patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction who were admitted to neurology department of our hospital from January 2016 to June 2017 were randomly selected as the objects of this study and divided into two groups according to the random number table method,50 cases in each group.The patients in the control group were given conventional treatment,and the patients in the observation group were treated with Ginkgo Leaf Extract and Dipyridamole Injection based on the control group.The clinical efficacy,NIHSS scores,serum Hcy,hs-CRP and Barthel scores were compared between the two groups after intervention with different medication regimens.Results The total effective rate of the observation group was 92.00%(46/50),which was significantly higher than that of the control group (80.00%,40/50),the difference was statistically significant (P＜0.05).Before treatment,the NIHSS scores were compared in both groups,and the difference was not statistically significant(P＞0.05).After treatment,the NIHSS scores of the observation group was(2.5±0.3)points,which was significantly lower than that of the control group of(6.5±0.8)points,and the difference was statistically significant(P＜0.05).Before treatment,the levels of serum Hcy and hs-CRP were compared in both groups,and the differences were not statistically significant (P＞0.05).After treatment,the levels of serum Hcy and hs-CRP of observation group were significantly lower than those of control group,and the differences were statistically significant(P＜0.05).Before treatment,the Barthel scores were compared in both groups,and the difference was not statistically significant (P＞0.05).After treatment,the NIHSS scores of the observation group was(78.9±5.3)points,which was significantly higher than that of the control group of(63.1±1.9)points,and the difference was statistically significant(P＜0.05).Conclusion Application of Ginkgo Leaf Extract and Dipyridamole Injection has definite therapeutic effect and good clinical curative effect in treatment of young and middle-aged patients with acute cerebral infarction.It plays an important role in improving the patients′neurological function,serum level and the prognosis of activities of daily living,which is worthy of popularization and application.
2018 Vol. 25 (1): 132-134转138 [Abstract] ( 128 ) HTML (30 KB)  PDF  (0 KB)  ( 32 )
135 Feasibility analysis of glucocorticoid in the treatment of severe heart failure
HUANG Zhong-yi
Objective To investigate the clinical efficacy of glucocorticoids in the treatment of severe heart failure with Irbesartan and Hydrochlorothiazide.Methods 50 patients with severe heart failure treated in our hospital from January 2016 to July 2017 were selected as subjects and randomly divided into control group and study group according to random number method,25 cases in each group.The patients in the control group were treated with Irbesartan and Hydrochlorothiazide,and patients in the the study group were treated with glucocorticoids combined with Irbesartan and hydrochlorothiazide.The clinical efficacy,echocardiographic findings,changes of neuroendocrine factors and the distance of 6 min walk test were compared between the two groups.Results The total effective rate of the study group (92.00%)was significantly higher than that of the control group(70.00%),and the difference was statistically significant(P＜0.05).After the intervention,two groups of LVISD,LVIDD,LVEDV and LVESV both were significantly lower than before the intervention,LVEF was significantly higher than before the intervention,and the differences were statistically significant(P＜0.05).The LVISD,LVIDD,LVEDV and LVESV in the study group were significantly lower than those in the control group,LVEF was significantly higher than that in the control group,and the differences were statistically significant(P＜0.05).After the intervention,two groups of ALD,COR,ET,TGF-Β1and Hs-CRP both were compared,and the differences were statistically significant(P＜0.05),while the ANP and Β2-MG were compared,the differenced were not statistically significant(P＞0.05).After the intervention,the distance of 6 min walking test in the study group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Glucocorticoid-assisted Irbesartan and Hydrochlorothiazide in the treatment of severe heart failure can improve neuroendocrine factor secretion and cardiac function and improves clinical efficacy.
2018 Vol. 25 (1): 135-137 [Abstract] ( 115 ) HTML (33 KB)  PDF  (0 KB)  ( 34 )
139 Summary of academic thoughts and clinical experience for professor WANG Yong-yan
ZHANG Li-mei;HU Yuan-hui;CHEN Jin
Professor WANG Yong-yan has been engaged in medicine and teaching for more than 50 years,he creatively established and improved the system of traditional Chinese medicine (TCM)diagnosis and treatment of stroke,and put forward the formulation TCM diagnosis and curative effect evaluation standard of stroke,which played a leading role and exemplary role for the study on standardization of diagnosis and treatment of common diseases and syndromes in clinical departments.Professor Wang made a clear interpretation of the concept of abnormal collaterals for the first time,pointed out that the abnormal collaterals is the collateral disease of the pathological process and pathogenesis,the source of disease and syndrome.It is of great significance to deepen the analysis of pathogenesis of abnormal collaterals,to seek common pathogenesis of syndromes,to determine the treatment and treatment of prescription and to determine the prognosis.On this basis,developing and innovating,he combined theory and practice for the treatment of cardiovascular disease,put forward the heart-YIN deficiency and wind-driven heart collaterals is one of the pathogenesis of premature ventricular contraction,according to the basic pathogenesis of this disease,he formed the experienced prescription:Yangyinxifengfumai Decoction.The purpose of this study is to summarize the academic thought and clinical experience of Professor WANG Yong-yan,in order to provide reference for the clinical prevention and treatment of cardiovascular and cerebrovascular diseases.
2018 Vol. 25 (1): 139-143 [Abstract] ( 133 ) HTML (44 KB)  PDF  (0 KB)  ( 24 )
144 Short-and long-term clinical effect of multiple-superficial needling on Ashi point as a main therapy in the treatment of migraine with deficiency of qi and blood
TANG Tong-bo
Objective To explore the short-and long-term clinical effect of multiple-superficial needling on Ashi point as a main therapy in the treatment of migraine with deficiency of qi and blood.Methods From January 2015 to December 2016,60 patients with migraine of deficiency of qi and blood treated in our hospital were divided into the two groups by a random number table,and there were 30 cases in each group.The control group was treated with Flunarizine Hydrochloride Capsules,and the research group,on the basis of the control group,main therapy of multiple-superficial needling on Ashi point was added.The clinical effect between the two groups was compared.Results The total effective rate in a short term in the research group was 93.33%,which was significantly higher than that in the control group accounting for 80.00%(P＜0.05).After treatment,the headache score in the research group was greatly lower in comparison of that in the control group(P＜0.05).The blood flow velocity of ICA-MCA,ACA,and PCA in the research group was displayed statistical significance compared with that in the control group (P＜0.05).The total effective rate in a long term was 86.66%in the research group,which was much higher than that in the control group(60.00%)(P＜0.05).Conclusion In the treatment of migraine patients with deficiency of qi and blood,main selection of multiple-superficial needling on Ashi point obtains short-and long-term effect by greatly improving the cerebral blood flow,which is worthy of application and promotion in clinic.
2018 Vol. 25 (1): 144-146 [Abstract] ( 131 ) HTML (29 KB)  PDF  (0 KB)  ( 42 )
147 Clinical analyzing of acupuncturing sichong point combined with Yishen Huatan Decoction treating aphasia after cerebral arterial thrombosis
GAO Hai-song
Objective To explore the clinical effect of acupuncturing sichong point combined with Yishen Huatan Decoction treating aphasia after cerebral arterial thrombosis.Methods Clinical data of 80 patients with cerebral arterial thrombosis treated in our hospital from February 2015 to March 2017 analyzed and patients were divided into the two group by different treatment methods,and there were 40 cases in each group.The control group was given conventional treatment,while the observation group was given acupuncturing sichong point combined with Yishen Huatan Decoction on the basis of the control group.CRRCAE score of patients in the two group before and after treatment was observed,and the total effective rate and the change of the severity of aphasia were observed in the two groups.Results The expression,name,reading,rehearsal score of patients in the two group were no statistical difference before treatment(P＞0.05).After treatment,the expression,name,reading,rehearsal score of patients in the two group were higher than those before treatment,and the expression,name,reading,rehearsal score of patients in the observation group after treatment were higher than those of the control group(P＜0.05).The total effective rate of the patients in the observation group was higher than that of the control group (P＜0.05).The severity of aphasia in the observation group was better than that of the control group (P＜0.05).ConclusionFor acupuncturing sichong point combined with Yishen Huatan Decoction treating aphasia after cerebral arterial thrombosis,language ability recovery is obvious,curative efficience is good,it is worthy of clinical promotion and application.
2018 Vol. 25 (1): 147-149 [Abstract] ( 137 ) HTML (28 KB)  PDF  (0 KB)  ( 28 )
150 The influence of early nursing intervention on the knowledge-attitudepractice and pregnancy outcomes of women with gestational diabetes mellitus
XIONG Hua;YANG Jinhua
Objective To study the influence of early nursing intervention on the knowledge-attitude-practice and pregnancy outcomes of women with gestational diabetes mellitus.Methods 96 cases of gestational diabetes mellitus in our hospital from February 2015 to February 2016 were selected and divided into observation group and control group according to the random number table grouping method,48 cases in each group.with the grouping method of random number table.Practice routine nursing measures in the control group while practicing early nursing intervention on the basis of routine nursing measures in the observation group.Compare the maternal pregnancy outcomes of the two groups.Results The awareness and knowledge of diabetes and the compliance behavior of the observation group surpass those of the control group;and the occurrence of neonatal asphyxia,neonatal respiratory distress syndrome,neonatal pneumonia and macrosomia ranks lower than the control group;the results are statistical significant relatively (P＜0.05).Conclusion The practice of early nursing intervention in women with gestationa diabetes mellitus can effectively prevent adverse pregnancy outcomes and occurrence of adverse events for maternal gestational diabetes mellitus;through the knowledgeattitude-practice mode health education to pregnant women,the patients′understanding and grasping of relevant knowledge concerning gestational diabetes can be promoted,thereby,the pregnancy outcomes of maternal gestational diabetes mellitus can be ameliorated and the occurrence of neonatal complications can be reduced;such method is thus worthy of being recommended in clinical practice.
2018 Vol. 25 (1): 150-153 [Abstract] ( 129 ) HTML (35 KB)  PDF  (0 KB)  ( 25 )
154 Effect of HY-D type computerintermediate frequency drug introduction in the treatment of juvenile idiopathic arthritis
XIE Gui-xiang;XU Yan; LIU Qing
Objective To observe the effect of HY-D type computer intermediate frequency drug introduction in the treatment of juvenile idiopathic arthritis.Methods100 childpatients with juvenile idiopathic arthritisadmitted treated in the department of rheumatology and immunology of our hospital from January 2011 to December 2012 were selected,and divided into the observation group and the control group according to the random number table,50 cases in each group.The control group received routine treatment and nursing.The observation group was given HY-D type computer intermediate frequency drug introduction on the basis of the control group.The inflammatory indexes,treatment effect and recovery time were compared between the two groups before and after treatment.Results There were no significant differences in C-reactionprotein(CRP),interleukin-1β (IL-lβ),interleukin 6(IL-6)and interleukin-7(IL-7)between the two groups before treatment(P＞0.05).After treatment,the levels of CRP、IL-lβ、IL-6 and IL-7 in the observation group were significantly lower than those in the control group,the difference was statistically significant(P＜0.05).The proportion of ACR20,ACR50 and ACR70 in the observation group were obviously higher than those in the control group,the difference was statistically significant(P＜0.05).The swelling disappearance time,pain disappearance time,erythrocyte sedimentation rate(ESR),recovery time and hospitalization time of the observation group were significantly shorter than those of the control group,the difference was statistically significant(P＜0.05).Conclusion The treatment of HY-D type computerintermediate frequency drug introduction can effectively improve the effect and shorten the recovery time in children with juvenile idiopathic arthritis.
2018 Vol. 25 (1): 154-156转159 [Abstract] ( 111 ) HTML (32 KB)  PDF  (0 KB)  ( 30 )
157 The application effect of systematic prenatal health education in pregnant women
XIONG Xue-lian
Objective To explore the application effect of systematic prenatal health education in pregnant women.Methods From October 20,2016 to January 20,2017,100 pregnant women admitted to our hospital were selected as the subjects,and evenly divided into observation group (systematic prenatal health education)and control group(routine health education)in random,50 cases in each group.The score of psychological state,labor time and delivery mode were compared between the two groups.Results The SAS score of pregnant women in the observation group was(35.06±1.48)points,and SDS score was(34.84±1.87)points.In the control group,they were(48.31±1.02)points and(49.66±1.35)points respectively,the differences were statistically significant after comparison between the two groups (P＜0.05).The first stage of labor for pregnant and lying-in woman was(6.82±1.02)h and the second stage of labor was(32.61±1.87)min in the observation group,which were both shorter compared with those in the control group for(9.99±1.14)h in the first labor stage and(55.99±1.35)min in the second stage respectively,the differences were statistically significant(P＜0.05).The natural delivery rate in the observation group (92.00%)was significantly higher than that in the control group(72.00%),the difference was statistically significant(P＜0.05).Conclusion Systematic prenatal health education for pregnant women can effectively improve the bad mood,and also play an important role in increasing the clinical natural delivery rate,which is worthy of promotion.
2018 Vol. 25 (1): 157-159 [Abstract] ( 114 ) HTML (27 KB)  PDF  (0 KB)  ( 28 )
160 Application effect of early systematic rehabilitation nursing in patients with acute cerebral infarction complicated with hemiplegia
ZHU Li-juan;HE Wen-jing;ZHANG Xiao-ying;YOU Cai-fen
Objective To explore the effect of early systematic rehabilitation nursing in acute cerebral infarction patients complicated with hemiplegia.Methods64 cases of acute cerebral infarction patients complicated with hemiplegia treated in our hospital from December 2015 to December 2016 were selected as the subjects,and divided into two groups according to the nursing methods.The control group(33 cases) received routine nursing care and the observation group(31 cases)received early systematic rehabilitation nursing.The Berg balance scale(BBS)and Holden Functional Ambulation Category(Holden FAC)were used to assess the balance function and walking ability of the two groups,and the postoperative quality of life was also evaluated.Results The postoperative BBS scale and Holden FAC scores of two groups were significantly higher than those before treatment,the difference was statistically significant(P＜0.05).The scores of the observation group were significantly higher than those of the control group,the difference was statistically significant(P＜0.05).The MOS 36-Item Short-Form Health Survey (SF-36)scores of observation group were higher in general health,energy,physical pain,physical function and physiological role than those in the control group,the difference was statistically significant(P＜0.05).ConclusionApplication of early systematic rehabilitation nursing in acute cerebral infarction patients complicated with hemiplegia can not only significantly improve the body function and speed up rehabilitation,but also improve the overall quality of life,which is worthy of clinical application.
2018 Vol. 25 (1): 160-162 [Abstract] ( 129 ) HTML (29 KB)  PDF  (0 KB)  ( 39 )
163 Effects of family visit nursing guided by PDCA (quality circle)theory on compliance behavior and family function in elderly hypertensive patients
LIAO Hong-ying
Objective To explore the effect of family visit nursing guided by PDCA theory on compliance behavior and family function in elderly patients with hypertension.Methods 90 patients admitted to our hospital for elderly patients with hypertension from February 2015 to April 2017 were selected as the subjects,and divided into the control group and observation group by random number table method,45 cases in each group.Patients in the control group were treated with routine family visit after discharge,and patients in the observation group were treated with the family visit care under the theory guide of PDCA,6 months a course of treatment.The difference of nursing effect between the two groups was compared.Results After the intervention,the compliance score and family function score of the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The total satisfaction rate of the observation group(93.33%)was higher than that in the control group(75.56%),the difference was statistically significant(P＜0.05).Conclusion The family visit nursing model guided by PDCA theory can effectively improve the treatment compliance and family function of elderly patients with hypertension,which is worthy of promotion.
2018 Vol. 25 (1): 163-165转169 [Abstract] ( 118 ) HTML (30 KB)  PDF  (0 KB)  ( 25 )
166 The application effect of nursing intervention in the treatment of diabetic foot by vacuum sealing drainage
ZHAO Xue-ying;XU Dan;XU Yang
Objective To explore the effect of nursing intervention in the treatment of diabetic foot by vacuum sealing drainage.Methods A total of 104 patients with diabetic foot from December 2012 to December 2014 treated in our hospital were selected as the subjects.By a random number table,they were evenly divided into control group and observation group,52 cases in each group.Patients in the control group were treated with routine nursing.And the patients in observation group were treated with nursing intervention.All of the patients were treated with vacuum sealing drainage.The treatment compliance,recovery,hospitalization,complications,and nursing satisfaction were compared between the two groups.Results In the observation group,the time of blood glucose control,wound healing time,dressing change,hospital stay,and hospital cost were (2.4±0.8)d,(12.7±1.8)d,(1.4±0.3)times,(14.7±2.5)d,(10 327.5±1234.8)yuan,which were significantly lower than those in the control group,(4.2±1.0)d,(17.6±2.3)d,(3.5±1.6)times,(19.8±3.1)d,and(13 473.6±2490.3)yuan accordingly.The dressing duration in the observation group([10.3±1.2]d)was shorter than that in the control group [(5.4±0.7)d].The incidence of complications,treatment compliance,and nursing satisfaction was 1.9%,98.1%,and 96.2%respectively,all superior to those in the control group with 15.4%,86.5%,and 82.7%,the differences were statistically significant(P＜0.05).Conclusion In the treatment of diabetic foot by vacuum sealing drainage,nursing intervention can shorten the course of treatment,improve safety,remarkably increase the treatment compliance and nursing satisfaction,which is worthy of clinical application.
2018 Vol. 25 (1): 166-169 [Abstract] ( 136 ) HTML (33 KB)  PDF  (0 KB)  ( 34 )
170 Application analysis of high quality nursing intervention in peritoneal dialysis patients with chronic renal failure
HE Xiu-juan
Objective To explore the application of high quality nursing intervention in patients with chronic renal failure undergoing peritoneal dialysis.MethodsAltogether 86 patients with chronic renal failure undergoing peritoneal dialysis treated in our hospital from June 2015 to August 2016 were selected as the subjects,and divided into the experiment group and the control group by simple random method,with 43 cases in each group.The experiment group was treated with high quality nursing intervention,while the control group received routine nursing care.The incidence of complications,improvement of nutritional status and quality of life were compared between the two groups.Results After the intervention,the incidence of complications in the experiment group was lower than that in the control group,with statistically significant difference(P＜0.05).After the intervention,the Malnutrition-inflammation Scale(MIS)score of the experiment group was lower than that in the control group,with statistically significant difference (P＜0.05).After the intervention,the body mass index,serum albumin and hemoglobin of the experiment group were higher than those in the control group,with statistically significant difference(P＜0.05).After the intervention,the scores of physiological function,body pain,general health and mental health in the experimental group were higher than those in the control group,with statistically significant difference (P＜0.05).ConclusionHigh quality nursing can improve the quality of life,reduce the complications and improve the nutritional status of peritoneal dialysis patients with chronic renal failure.
2018 Vol. 25 (1): 170-172 [Abstract] ( 131 ) HTML (28 KB)  PDF  (0 KB)  ( 26 )
173 Effect of Evidence-Based Nursing on Prevention of Pressure Sores in Stroke Patients
ZHANG Su-rong;CHEN Yu-shan;CHEN Yu-zhu;XU Huan-wei
Objective To study the effect of evidence-based nursing in preventing pressure sores in stroke patients.Methods The clinical data of 64 stroke patients admitted to our hospital from June 2015 to June 2017 and needed to be on bed rest were selected as the subjects,and retrospectively analyzed.32 cases with evidence-based nursing care were taken as the observation group.32 cases with routine nursing were taken as the control group.After nursing intervention,the incidence of pressure ulcers,Braden score and nursing satisfaction of the two groups were compared and analyzed,in order to explore the clinical effect of evidence-based nursing.Results The incidence rate of pressure ulcer of the observation group (3.13%)was significantly lower than that in control group (15.63%),with statistically significant difference (P＜0.05).The Braden score of the observation group was significantly higher than that in the control group,with statistically significant difference (P＜0.05).The nursing satisfaction of patients in the observation group and their family members(93.75%)was significantly higher than that in the control group(65.63%),with statistically significant difference(P＜0.05).Conclusion The application of evidence-based nursing in stroke patients who are in need of clinical nursing of bed rest,can significantly reduce the incidence of pressure ulcers and improve the nursing satisfaction degree of patients and their family members,which is suitable for clinical application.
2018 Vol. 25 (1): 173-176 [Abstract] ( 133 ) HTML (33 KB)  PDF  (0 KB)  ( 32 )
177 Effect of nursing intervention on complications of thoracoscopic lung cancer patients undergoing anesthesia convalescence
LI Jian
Objective To explore the nursing intervention of thoracoscopic lung cancer radical mastectomy and its effect on the complications of anesthesia recovery.Methods From August 23,2015 to April 11,2017,70 patients with thoracoscopic lung cancer underwent radical surgery were selected as the subjects,and divided into control group and observation group according to different nursing models,35 cases in each group.The control group was given basic intervention,and the observation group took the comprehensive nursing on the basis of the control group.The incidence and quality of life of the two groups were observed.Results The incidence of arrhythmia (0.00%),hypoxemia (2.86%),agitation(5.71%)and gastrointestinal discomfort(8.57%)in observation group were lower than those in control group,the differences were statistically significant (P＜0.05).Social relations,physical life,psychological status,physiological function scores in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).Conclusion In patients with thoracoscopic lung cancer radical resection,effective nursing interventions can improve the quality of service and reduce the complications of anesthesia recovery.
2018 Vol. 25 (1): 177-179 [Abstract] ( 161 ) HTML (27 KB)  PDF  (0 KB)  ( 37 )
180 Observation of the effect of perioperative nursing in the bone arthroplasty
ZHONG Sai-qiong;ZHU Yan-ni;ZHENG Bin-na
Objective To explore the effect of perioperative nursing in the bone arthroplasty.Methods A total of 102 patients treated in our hospital by bone arthroplasty from May 15,2016 to May 15,2017 were selected as the subjects.According to the sequence of admission,they were evenly divided into conventional group and experimental group,51 cases in each group.The conventional group was provided general perioperative nursing,while the experimental group treated with clinical nursing path intervention during perioperative period.The nursing effect was compared between the two groups.Results The incidence of infection in the experimental group was 1.96%,lower than that in conventional group accounting for 15.69%,the difference was statistically significant(P＜0.05).The nursing satisfaction in the experimental group was 94.12%,which was higher than that in the conventional group for 76.47%,the difference was statistically significant(P＜0.05).The hospital stay and time to be off bed in the experimental group were shorter compared with those in the conventional group,the differences were statistically significant(P＜0.05).The incidence of postoperative complications in the experimental group was 3.92%,lower than 17.65%in the conventional group,the difference was statistically significant(P＜0.05).Conclusion Application of clinical nursing path intervention during perioperative period for patients with bone arthroplasty is beneficial to reduce the incidence of postoperative infection and improve nursing effect,which is worthy of practice and promotion.
2018 Vol. 25 (1): 180-182 [Abstract] ( 145 ) HTML (28 KB)  PDF  (0 KB)  ( 28 )
183 Effects evaluation of clinical nursing pathway in painless endoscopic diagnosis and treatment
CHENG Han-rong
Objective To study the effects of clinical nursing pathway in painless endoscopic diagnosis and treatment.Methods 80 patients who conducted painless endoscopic diagnosis from February 2014 to October 2014 of our hospital were selected as objects.Patients were divided into two groups according to different nursing mode,and each group was 40 cases.Patients in control group were given routine nursing,and patients in study group were given clinical nursing pathway on the basis of control group.Vital signs liked systolic pressure and heart rate,patient care satisfaction,occurrence situation of adverse effects and fall rate in two groups before and after treatment were detected and accounted,and the results were analyzed and compared.Results Before treatment,the difference of systolic pressure and heart rate between two groups were not obvious,and the difference had no statistical significance(P＞0.05);the heart rate is unchanged (P＞0.05).After treatment,the systolic pressure and heart rate in study group had obvious difference compared with control group (P＜0.05).The total care satisfaction in study group,obvious higher than that was in control group,and the difference was statistical significance (P＜0.05).The total incidence rate of adverse effects and fall rate in study group were respectively 7.5%and 2.5%,which had significant difference compared with control group (P＜0.05).Conclusion Clinical nursing pathway can obvious decrease the fall rate of patients after painless endoscopic diagnosis and treatment,which is helpful to the diagnosis and treatment proceed smoothly of and with application value in clinical.
2018 Vol. 25 (1): 183-185 [Abstract] ( 135 ) HTML (29 KB)  PDF  (0 KB)  ( 34 )
186 The application of comprehensive nursing in the treatment of acute attack of children with asthma in budesonide atomization
MIAO Ling-Xia
Objective To study the budesonide aerosol inhalation in treating children asthma acute application and application effect of comprehensive nursing care.Methods Selection during May 2015 to August 2016,86 cases of acute attack of asthma,children on average,according to the simple randomized divided into the control group and the observation group,with 43 cases in each group,an integrated care,compared two groups after treatment with intervention effect evaluation,adverse reaction,nursing adverse events,satisfaction evaluation,and so on and so forth.Results Observation group total effective rate is significantly higher than the control group,the difference was statistically significant(P＜0.05).Observation group after treatment with 1 incidence of nursing adverse events (2.23%)waslower than the control group (16.30),the difference was statistically significant(P＜0.05).Observation group after treatment with adverse reactions to 0 was lower than the control group (13.95%),the difference was statistically significant(P＜0.05).Observation group satisfaction was higher than the control group,the difference was statistically significant(P＜0.05).ConclusionChildren with asthma acute attack using budesonide atomization inhalation therapy after application of comprehensive care,treatment effect is remarkable,the low incidence of adverse events,patient satisfaction is high,is worth clinical use.
2018 Vol. 25 (1): 186-188 [Abstract] ( 125 ) HTML (27 KB)  PDF  (0 KB)  ( 41 )
189 Nursing observation of Doxofylline combined with self blood acupoint injection in the treatment of bronchial asthma
YE Xiao-qian;HUANG Cheng-zhi;WANG Geng-jie;HONG Lan;KE Hua-qi;YANG Yan
Objective To investigate the effect of Doxofylline combined with self blood acupoint injection in the treatment of bronchial asthma clinical curative effect and nursing.Methods 60 patients with bronchial asthma diagnosed and treated in our hospital from February 2016 to July 2017 were selected as the study subjects,were randomly divided into observation group and treatment group,with 30 cases in each group.The observation group was treated with Doxofylline treatment,the patients in the treatment group was treated with Doxofylline combined with self blood acupoint injection treatment and nursing intervention with the appropriate,the clinical treatment effect and adverse reactions of two groups of patients were compared.Results In the observation group significantly higher than that of the control group ((P＜0.05));The FEV1 and PEF indexes in the treatment group were significantly higher than those in the observation group(P＜0.05),while the incidence of adverse reactions was significantly lower than that in the observation group,and the differences were statistically significant(P＜0.05).Conclusion Doxofylline combined with self blood acupoint injection for treatment of bronchial asthma curative effect,proper nursing intervention with the treatment process,can significantly improve the treatment efficiency,improve lung function,reduce the incidence of adverse reactions,worthy of further clinical application.
2018 Vol. 25 (1): 189-191 [Abstract] ( 151 ) HTML (29 KB)  PDF  (0 KB)  ( 28 )
192 Systematic nursing in laparoscopic Meckel's diverticulum resection in children
LIU Qiu-ju;WANG Bin
Objective To explore the system of nursing in laparoscopic resection of Meckel′s diverticulum in children.MethodsThe 120 patients who underwent laparoscopic mekel diverticectomy in our hospital from January 2015 to December 2016 were divided into the control group and the research group according to the random number method.60 cases in each group.The control group received routine nursing intervention,and the study group adopted systematic nursing intervention.To compared two groups of patients with postoperative 7d fecal occult blood test negative rate,30 d re examination of the effective rate of the treatment and nursing satisfaction.Results The study group patients with postoperative 7 d fecal occult blood test negative rate (95.00%)in study group was significantly higher than the control group(68.33%),between the two groups was statistically significant(P＜0.05).The effective rate of postoperative 30 d reexamination in the study group(98.33%)was significantly higher than that in the control group(73.33%),and the difference between the two groups was statistically significant(P＜0.05).The satisfaction degree of the patients in the study group(96.66%)was significantly higher than that of the control group(83.33%),the difference between the two groups was statistically significant(P＜0.05).conclusion systematic nursing in laparoscopic resection of Meckel's diverticulum in children can effectively improve the cure rate and the effective rate of treatment and patient satisfaction,has a positive effect on patients,it is worth popularizing in clinical use.
2018 Vol. 25 (1): 192-194 [Abstract] ( 124 ) HTML (28 KB)  PDF  (0 KB)  ( 32 )
195 Application effect of rehabilitation nursing in total hip replacement
PAN Yue-zhi;QIU Ting;XIE Xiao-li
Objective To explore the application effect of rehabilitation nursing in total hip replacement.Methods 92 patients with total hip arthroplasty in department of orthopedics from February 2014 to December 2016 were selected as the research objects.They were divided into experimental group and control group by touch ball method,46 cases in each group.The experimental group was used rehabilitation nursing,while the control group was only used routine nursing care.The Barthel index,hip joint Harris score,postoperative complications and SDS and SAS scores were compared between the two groups before and after intervention.Results There was no significant difference in before intervention Barthel and Harris scores between the two groups(P＞0.05).Second weeks,fourth weeks and twelfth weeks after the intervention,the scores of the experimental group were higher than those of the control group,and the difference was statistically significant(P＜0.05).The incidence of complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in SDS and SAS scores between the two groups before intervention (P＞0.05),After the intervention,the experimental group was better than the control group,the difference was statistically significant(P＜0.05).Conclusion Rehabilitation nursing is beneficial to the functional recovery of patients after total hip arthroplasty in department of orthopedics,and which can improve the psychological state and reduce complications.
2018 Vol. 25 (1): 195-197 [Abstract] ( 129 ) HTML (29 KB)  PDF  (0 KB)  ( 31 )
Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech