再生障碍性贫血感染危险因素分析

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Abstract Objective To investigate the infection characteristics and risk factors of aplastic anemia patients to provide the theoretical basis for effective prevention and treatment.Methods 330 patients with aplastic anemia treated in the Hematology Department of Affiliated Hospital of Southwest Medical University from May 2013 to May 2017 were selected as object.Retrospective investigation and analysis method was used to analyze the related infection characteristics and the related risk factors of patients.Data were analyzed by SPSS 17.0 software.Results Among 330 patients with aplastic anemia,128 cases had infections(38.8%),46 cases of hospital infection(35.9%),82 cases of community infection(64.1%),111 cases of single infection(86.7%),14 cases of double infection(10.9%),3 cases of multiple infection(2.4%).A total of 19 cases of pathogenic bacteria were trained,Gram-negative bacteria in 12 case(63.2%),Gram-positive bacteria in 4 cases(21.1%),fungal infections in 3 cases(15.7%).Single factor analysis showed that the hospitalization time,white blood cell count,neutrophils count,agranulocytosis duration,albumin content,invasive operation and the application of hormone were risk factors for infection in patients with aplastic anemia (P＜0.01).Multivariate analysis showed that the hospitalization time,agranulocytosis duration,albumin content,number of neutrophils were independent risk factors for aplastic anemia with infection (P＜0.01).Conclusion In clinic,positive and effective preventive measures should be taken according to the above risk factors to reduce the incidence of infection in patients with aplastic anemia.

Key words： Aplastic anemia Infection Risk factors

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	HE Hong-xiu
	LI Qin
	LI Xiao-ming

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HE Hong-xiu,LI Qin,LI Xiao-ming. Analysis of risk factors of infection in aplastic anemia[J]. 中国当代医药, 2018, 25(1): 27-30.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I1/27

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