Objective To investigate the overall efficacy and safety of sedative analgesia with alone Sufentanil in endoscopic hemostasis in patients with upper gastrointestinal hemorrhage.Methods60 patients received endoscopic hemostasis in our hospital from October 2016 to August 2017 were selected and randomly divided into the low dose Sufentanil+Propofol group(the PS group,n=30)and the Sufentanil group(the S group,n=30).The anesthesia effect,PACU residence time,vital signs,the incidence rate of adverse events and the satisfaction degree of patients and endoscopic were observed.Results The heart rate,mean arterial pressure and pulse oximetry during surgery of the PS group were significantly higher than those of the S group(P＜0.01).The incidence rate of severe hypotension and severe respiratory depression in the PS group were higher than that in the S group(P＜0.01).And the PACU residence time of the PS group was significantly longer than that of the S group (P＜0.01).There was no significant difference in the incidence rate of adverse events such as nausea,hematemesis,cough,severe physical activity between the two groups.And there was no significant differences in patient satisfaction degree and endoscopic satisfaction degree between the two groups(P＞0.05).Conclusion Sedative with alone Sufentanil also provides a good surgical environment and patient experience for upper digestive haemorrhagic endoscopic hemostasis and provides a safer environment for intravenous anesthesia than Propofol.