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Quick Search     Adv Search 2017 Vol. 24, No. 3 Published: 2017-01-28   4 Experimental study on immune regulation effect of Oviductus ranae in mice WANG Yan-wu；ZHAO Peng；QIN Guang-qiu；HE Li；FU Wei-zhong；ZHANG Lu-juan Objective To explore the effect of Oviductus ranae on the function of immunoregulation.Methods 240 mice were randomly divided into 6 groups of immune group,each group had 40 mice,each immune group was divided into low, medium and high dose group[334,667,1344 mg/(kg·BW)]and negative control group according to recommended oral dose (5,10,20 times)of Oviductus ranae 10 rats in each group.The mice were given intragastric administration according to volume of 0.2 ml/(10 g·BW),intragastric administration was given 1 time a day,and the immune indexes were measured after continuous intragastric administration of 30 d.Results The results of Oviductus ranae dose groups in comparison with the negative control group showed that proliferation and transformation of splenic lymphocyte were enhanced(P＜0.05);promoting mice late hairstyle allergy(P＜0.05);quantity of mice antibody-producing cell and sheep erythrocyte antibody levels in serum were raised(P＜0.05);mononuclear celiac macrophage phagocytic activity were increased(P＜0.05); the activity of NK cells in mice was inhanced(P＜0.05).Conclusion It is suggested that Oviductus ranae can enhance immune function. 2017 Vol. 24 (3): 4-6 [Abstract] ( 194 ) HTML (37 KB)  PDF  (0 KB)  ( 38 ) 7 Quantitative difference analysis of chromatin structure across the 5′proximal region of human RAG2 and study of its transcriptional regulatory mechanisms on the accessible areas XUE Wen-yu；ZENG Yan；WEI Xing-cheng Objective To study molecular mechanism of the regulation of RAG2 expression regulated the human recombination activating gene 2(RAG2)5′proximal chromatin accessible areas.Methods To compare the open states change of chromatin of RAG positive and negative lymphocytes as well as non lymphocyte chromatin,chromatin accessibility by real-time polymerase chain reaction(CHART-PCR)was used for DNaseⅠanalysis of RAG2 gene 5′proximal regions of hypersensitive sites(DHS).Double luciferases reporter assay was used to examine the transcriptional regulation effects of the DHS regions.Electrophoresis mobility shift assay and chromatin immunoprecipitation assays were used to detect the binding of GATA3 in vitro or in vivo.PCR site-directed mutant assay and dominant-negative mutant assay were used to identify the regulatory effects of GATA3 on the reporter gene(in vitro),as well as on RAG2 gene(in vivo). Results In T and B cells,the chromatin structures of 5′proximal region of human RAG2 were in distinct open states.In RAG positive T cells,the activity of RAG2 core promoter corresponded to its specific DHS.GATA3,a T-cell specific transfactor,bound to a highly conserved sequence within the specific DHS,and increased the expression of the reporter genes as well as RAG2 mRNA of the T cells in vivo.Conclusion RAG2 gene 5′proximal area through open states change of chromatin regulate the specificity of the gene expression,GATA3 regulates the expression of endogenous RAG2 in T cells by binding to highly conserved DHS regions. 2017 Vol. 24 (3): 7-12转16 [Abstract] ( 143 ) HTML (51 KB)  PDF  (0 KB)  ( 36 ) 13 Research on bone marrow stromal cells autotransplantation into rabbit′s sciatic nerve HE Xiao；DENG Li-li Objective To observe the ability and safety of autologous bone marrow stromal cells(BMSCs)as seed cells in repairing long distance defect of sciatic nerve in rabbits,and to explore the feasibility of BMSCs differentiating into neuron-like cells in sciatic nerve injury model.Methods BMSCs were injected into rabbit model of sciatic nerve injury, after isolated,cultured,induced,and identificated.Then electron microscope and immunohistochemisty were performed at the 1st,2nd,4th,8thand 16thweeks after cell transplantation.Results After transplantation,there were different degrees of regenerated nerve fibers between transplanted side and controlled side,but the number of nerve fibers was significantly reduced in control group,compared with the transplantation group(t=175.88,P＜0.01).Conclusion BMCSs transplantation has a well compatibility,which can promote the recovery of rabbit sciatic nerve dysfunction and provide an optimistic application prospect for cell replacement therapy. 2017 Vol. 24 (3): 13-16 [Abstract] ( 177 ) HTML (38 KB)  PDF  (0 KB)  ( 29 ) 17 Study the role of caveolin-1 in blood cerebrospinal fluid barrier QIAN Hua；LI Ya-jun Blood cerebrospinal fluid barrier is the key factor to maintain the stability of central nervous system. Important marker(caveolin-1)of endothelial cell caveolins plays an important role in the blood brain cerebrospinal fluid barrier.caveolin-1 is involved in the process of blood cerebrospinal fluid barrier by external aggression and signal transduction.At present,the research on caveolin-1 is still few.This retrospective study suggests that caveolin-1 has a very important significance in the blood cerebrospinal fluid barrier and central nervous system diseases. 2017 Vol. 24 (3): 17-19转23 [Abstract] ( 160 ) HTML (37 KB)  PDF  (0 KB)  ( 34 ) 20 Research progress of drug for acupoint injection therapy treating peripheral facial paralysis DU Yuan-hui；ZENG Qiang；LIU Li；CHEN Gui-quan There are many kinds of drugs for treating facial paralysis by acupoint injection,and the curative effect is good,but the method is not uniform.The related literatures about the treatment of peripheral facial paralysis(facial paralysis)by acupoint injection in the last 5 years are summarized,and the drugs,usage and dosage and curative effect of acupoint injection treating facial paralysis have been concluded in this paper,to provide reference for the choice of drugs. 2017 Vol. 24 (3): 20-23 [Abstract] ( 197 ) HTML (43 KB)  PDF  (0 KB)  ( 42 ) 24 Clinical effect of Entecavir combined with Heluoshugan Capsules treating hepatitis B cirrhosis of compensated stage ZHANG Li-yi；DING Guo-fengZHANG Li-yi1,2DING Guo-feng3▲ Objective To observe the clinical effect of Entecavir combined with Heluoshugan Capsules treating hepatitis B cirrhosis of compensated stage.Methods 82 patients with hepatitis B cirrhosis of compensated stage diagnosed and treated by department of gastroenterology in Central Hospital of Jiaozhou of Qingdao City from June 2011 to May 2012 were selected and they were randomly divided into treatment group of 41 cases and control group of 41 cases.Control group was treated with oral Entecavir Disket 0.5 mg,once a day,while the treatment group was treated with oral Heluoshugan Capsules for 5 capsules,three times a day,and taking Heluoshugan Capsules for 2 months and stopping 1 month and then continued to take according to the law,and both groups received 48 months treatment.Treatment effect between two groups was compared.Results Albumin(Alb)level in two groups were significantly different(t=6.351,P=0.017),the treatment group was better than the control group;the level of serum hyaluronie acid(HA),Laminin(LN),procollagen typeⅢ(PC-Ⅲ)and collagen typeⅣ-C(Ⅳ-C)were decreased significantly in treatment group than in control group, and the above-mentioned indexes were better than those in control group(P＜0.01).The negative conversion rate of treatment group(41.4%)was significantly higher than that of control group(14.6%)(P＜0.01).There was a statistical difference of the portal vein diameter between two groups(P＜0.01),but there was no significant difference in negative conversion rate of HBV-DNA(P＞0.05).Conclusion Entecavir combined with Heluoshugan Capsules treating hepatitis B cirrhosis of compensated stage can improve liver function,suppress viral replication persistently,and can delay or even reverse the progression of liver fibrosis,and it has clinical application value. 2017 Vol. 24 (3): 24-26转32 [Abstract] ( 150 ) HTML (36 KB)  PDF  (0 KB)  ( 33 ) 27 Effect of Octreotide Acetate Injection combined with Omeprazole Sodium Injection in the treatment of acute pancreatitis HUANG Jing-en；GAN Xiao-hai Objective To study the effect of Octreotide Acetate Injection combined with Omeprazole Sodium Injection in the treatment of acute pancreatitis.Methods 46 patients with acute pancreatitis admitted into our department from May 2013 to September 2016 were randomly divided into the observation group(n=23)and the control group(n=23).On the basis of routine treatment,the patients in the control group were treated with intravenous drip of Omeprazole Sodium Injection.Patients in the observation group were given continuous intravenous infusion of Octreotide Acetate Injection on the basis of the control group.The remission time of clinical symptoms and physical signs,and the time of laboratory test indicators returning to normal level were compared between two groups.The change of the level of serum C-reactive protein(CRP)and amylase were observed before and after treatment in both groups.The clinical therapeutic effect and incidence rate of complications were compared between the two groups.Results The time of the improvement of clinical symptoms and physical signs and the time of laboratory test indicators returning to normal level in the observation group were significantly shorter than those in the control group(P＜0.01);the level of serum CRP and amylase in the two groups after treatment were significantly lower than those before treatment(P＜0.01),and the level of serum CRP and amylase in the observation group were significantly lower than those in the control group(P＜0.01);the total effective rate was 87.0%in the observation group,and it was significantly higher than that of 60.9%in the control group(P＜0.05).The incidence rate of complications in the observation group was 8.7%,and it was significantly lower than that of 34.8%in the control group(P＜0.05).Conclusion Octreotide Acetate Injection combined with Omeprazole Sodium Injection can significantly improve the therapeutic effect of acute pancreatitis,promote the improvement of symptoms and recovery of the body,and reduce the inflammatory state and pancreatic injury. 2017 Vol. 24 (3): 27-29 [Abstract] ( 173 ) HTML (36 KB)  PDF  (0 KB)  ( 35 ) 30 Clinical efficacy and safety analysis of Sildenafil in the treatment of neonatal persistent pulmonary hypertension ZHENG Yu-hui；TANG Yi；SUN Hong-qin Objective To explore the clinical efficacy and safety of Sildenafil in neonates with persistent pulmonary hypertension(PPHN).Methods 60 patients with PPHN treated in our hospital from September 2014 to July 2016 were selected and randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with mechanical ventilation,and the treatment group was treated with Sildenafil.The clinical efficacy and safety of the two groups were compared.Results The pulmonary artery systolic pressure and oxygenation index in the observation group was lower than that in the control group,transcutaneous oxygen saturation in the observation group was higher than that in the control group,with significant difference(P＜0.05).There was no significant difference in the incidence rate of adverse events between the two groups(P＞0.05).Conclusion Compared with mechanical ventilation,the effect of neonatal continuous pulmonary hypertension in children with Sildenafil in the treatment of PPHN is ideal,drug safety is high,which can effectively improve the pulmonary artery systolic pressure in children,it is worthy of clinical promotion and application. 2017 Vol. 24 (3): 30-32 [Abstract] ( 162 ) HTML (30 KB)  PDF  (0 KB)  ( 37 ) 33 Application of quadruple therapy combined with Kangfuxin Liquid in patients with peptic ulcer and its effect on Hp eradication rate LIU Yong Objective To investigate the application of quadruple therapy combined with Kangfuxin Liquid in patients with peptic ulcer and its effect on Hp eradication rate.Methods 84 patients with peptic ulcer treated in our hospital from January 2014 to December 2015 were selected and randomly divided into the control group and the study group,42 cases in each group.The control group was treated with quadruple therapy,the study group was treated with quadruple therapy and Kangfuxin Liquid.The therapeutic effect and Hp eradication rate of the two groups were compared.Results The total effective rate of the study group was 95.2%,which was higher than 73.8%of the control group,with significant difference (P＜0.05).The Hp eradication rate of the study group was 92.9%,which was higher than 69.0%of the control group,with significant difference(P＜0.05).The recurrence rate of the study group was 15.4%,which was lower than 66.7%of the control group,with significant difference(P＜0.05).Conclusion The effect of quadruple therapy combined with Kangfuxin Liquid in the treatment of peptic ulcer is significant,can improve the eradication rate of Hp,which has important application value. 2017 Vol. 24 (3): 33-35转57 [Abstract] ( 142 ) HTML (36 KB)  PDF  (0 KB)  ( 41 ) 36 Effect of Meglucamine Diatrizoate plusing Simethicone in the treatment of early postoperative inflammatory intestinal obstruction ZHAO Xue-wen；CHEN Bo-tang Objective To investigate the effect of Meglumine Diatrizoate plus Simethicone in the treatment of early postoperative inflammatory intestinal obstruction.Methods 45 patients with early postoperative inflammatory intestinal obstruction who were treated in our hospital from January 2010 to December 2015 were retrospectively analyzed and randomly divided into the control group(n=20)and the treatment group(n=25).The control group was given routine Paraffin treatment,while the treatment group was treated with Meglumine Diatrizoate plusing Simethicone.The operation rate, complication rate,the postoperative first exhaust and defecation time,gastrointestinal decompression time and hospitalization time between the two groups were compared.Results There was no significant complications in the two groups during the conservative treatment.All cases were cured,there was no surgical treatment.The postoperative first exhaust and defecation time,gastrointestinal decompression time and hospitalization time in the treatment group was shorter than that in the control group,with significant difference(P＜0.01).Conclusion Meglumine Diatrizoate plus Simethicone in the treatment of early postoperative inflammatory intestinal obstruction may accelerate the recovery of intestinal function, shorten the time of hospitalization,it is worthy of clinical promotion and application. 2017 Vol. 24 (3): 36-38 [Abstract] ( 178 ) HTML (31 KB)  PDF  (0 KB)  ( 42 ) 39 Application effect comparison of I-SCAN technology and common high definition electronic colonoscopy in the diagnosis of colorectal polyps LI Bo；LIU Yang-lan；ZHANG Zong-sheng Objective To compare the application effect of I-SCAN technology and common high definition(HD)electronic colonoscopy in the diagnosis of colorectal polyps.Methods 86 patients underwent colonoscopy in our hospital from March to October in 2016 were selected and randomly divided into the experimental group and the control group, 43 cases in each group.The experimental group was given I-SCAN mode,and the control group was given ordinary HD model.The detection rates of colorectal polyps and adenomas,the coincidence rate of endoscopic pathological diagnosis and pathological biopsy results,the time of removing the endoscope and the degree of intestinal cleanliness in the two groups were compared.Results The detection rate of polyps in the experimental group was 58.14%,which was higher than 37.21%in the control group,with significant difference(P＜0.05).The detection rate of adenoma in the experimental group was 34.89%,which was higher than that in the control group(25.58%),with significant difference(P＜0.05).The total coincidence rate of colonoscopy pathological diagnosis and pathological biopsy in the experimental group was 95.00%,which was higher than that in the control group(55.56%),with significant difference(P＜0.05).There was no significant difference between the two groups in the time of removing the endoscope and the degree of intestinal cleanliness(P＞0.05).Conclusion Colonoscopy with I-SCAN technology can make the higher detection rate of polyps and adenomas,the endoscopic diagnosis rate of pathological type is higher,and the examination time has not been significantly prolonged,it is worthy of clinical promotion and application. 2017 Vol. 24 (3): 39-41 [Abstract] ( 185 ) HTML (34 KB)  PDF  (0 KB)  ( 45 ) 42 Effect of Tanreqing Injection on cytokines in patients with Pseudomonas aeruginosa pulmonary infection TU Si-yi；ZHANG Chuan-lin；WANG Chun-e Objective To observe the effect of Tanreqing Injection on cytokines in patients with Pseudomonas aeruginosa pulmonary infection.Methods 128 cases of pulmonary infection patients with Pseudomonas aeruginosa in our hospital from April 2013 to August 2014 were selected as research objects and divided into observation group(n=64)and control group(n=64)according to different treatment methods,patients in two groups were treated with conventional anti infection therapy according to the results of drug sensitivity,patients in the observation group were added with Tanreqing Injection.Clinical efficacy of two groups,serum cytokine levels of IL-6,IL-8 and IL-10 before and after treatment,and bacterial clearance rate after treatment were compared.Results Total effective rate in the observation group was 95.31%,which was significantly higher than 81.25%in the control group,the difference was statistically significant(P＜0.05);the levels of IL-10,IL-8 and IL-6 in two groups were significantly changed before and after treatment,and the levels of IL-8,IL-6 in the observation group was lower than that in the control group,the IL-10 level was higher than that in the control group,the difference was statistically significant(P＜0.05);Pseudomonas aeruginosa clearance rate in the sputum of the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The treatment of Tanreqing on the base of conventional anti-inflammatory and anti infective therapy can significantly improve therapeutic effect,and regulate cytokine levels.It is worth to be popularized in clinical application. 2017 Vol. 24 (3): 42-44 [Abstract] ( 151 ) HTML (35 KB)  PDF  (0 KB)  ( 34 ) 45 Effects comparison of different therapeutic course of Ilaprazole,bismuth and antibiotics in the treatment of Helicobacter pylori related chronic gastritis ZHAO Lan-min；SHI Zhen-dong Objective To observe the curative effect of one week therapeutic course and two weeks therapeutic course of Ilaprazole and Bismuth potassium citrate combined with two kinds of antibiotics in the treatment of Helicobacter pylori (Hp)related chronic gastritis.Methods According to random number table method,156 patients with Hp related chronic gastritis in our hospital from January 2013 to June 2015 were selected and randomly divided into group A(n=78)and group B(n=78).All patients were treated with Ilaprazole 5 mg,Bismuth potassium citrate 0.6 g,Amoxicillin 1.0 g and Levofloxacin 0.2 g,2 times a day.Group A and group B was treated with the drugs for one week and two weeks respectively.The clinical effect,Hp eradication rate and adverse reactions between two groups were compared.Results The total effective rate of group A and group B was 93.6%and 94.9%respectively,there was no significant difference between two groups(P＞0.05).Hp eradication rate of group B(89.7%)was obviously higher than that of group A(75.6%)，the difference was statistically significant(P＜0.05).Incidence rate of adverse reactions in group A and group B was 6.4%and 9.0%respectively, there was no significant difference between two groups(P＞0.05).Conclusion The cure rate and Hp eradication rate of two weeks therapeutic course of Ilaprazole and Bismuth potassium citrate combined with two kinds of antibiotics in the treatment of Hp related chronic gastritis were obviously better than one week therapeutic course,and their adverse reactions is similar. 2017 Vol. 24 (3): 45-47 [Abstract] ( 147 ) HTML (34 KB)  PDF  (0 KB)  ( 23 ) 48 Influence of positive end-expiratory pressure in different levels on hemodynamics in patients with acute respiratory distress syndrome YE Yong-shun；LI Wen-feng；LIU Hua Objective To explore the effect of positive end-expiratory pressure(PEEP)in different levels on hemodynamics in patients with acute respiratory distress syndrome(ARDS).Methods 36 ARDS patients from July 2014 to July 2015 were admitted into our intensive care unit in our hospital and were selected.All patients were treated with invasive mechanical ventilation.According to different levels of PEEP in the process of invasive mechanical ventilation,they were evenly divided into low PEEP group(＞5-8 cmH2O),medium PEEP group(＞8-12 cmH2O),and high PEEP group(＞12-16 cmH2O) respectively.Centralvenous pressure(CVP),mean arterial pressure(MAP),and heart rate 24 hours before and after treatment were compared between three groups.Additionally,inter-group difference of ΔCVP,ΔMAP,andΔHR before and after therapy was compared.Results Among comparisons of CVP,MAP and HR were compared before and after therapy, when application of PEEP,the CVP level were higher than these before treatment with statistical difference(P＜0.01).The levels of MAP and HR were lower than those before treatment after using PEEP,which were displayed statistical difference(P＜0.01).In comparison of ΔCVP and ΔMAP,the index in the high PEEP group was greatly larger than that of low PEEP group with statisticant difference(P＜0.05).There was no great obvious difference in ΔHR among the groups(P＞0.05).Conclusion With the increase of PEEP levels,the effect of invasive mechanical ventilation on hemodynamics in ARDS patients also increases accordingly. 2017 Vol. 24 (3): 48-50 [Abstract] ( 166 ) HTML (32 KB)  PDF  (0 KB)  ( 37 ) 51 Related factors affecting the occurrence of postoperative complications in patients with liver cirrhosis and portal hypertension YUAN Xing Objective To analyze the related factors of the occurrence of postoperative complications in patients with liver cirrhosis and portal hypertension.Methods The medical records of 80 patients with liver cirrhosis and portal hypertension were treated in our hospital from June 2013 to June 2016 were retrospectively analyzed in order to summa rize the relevant factors influencing on the occurrence of postoperative complications.Results Among 80 participants, 20 patients were occurred with postoperative complications accounting for 25.00%.The occurrence of postoperative complications in patients with liver cirrhosis and portal hypertension was related with ASA grading,Child-Pugh grading,operation of esophageal-gastric variceal ligation or not and usage of hand-assisted device,and albumin level and platelet count before surgery(P＜0.05).Conclusion The incidence of postoperative complications in patients with cirrhosis and portal hypertension is high,and active prophylactic measures should be taken to reduce it. 2017 Vol. 24 (3): 51-53 [Abstract] ( 133 ) HTML (30 KB)  PDF  (0 KB)  ( 47 ) 54 Effect comparison of PPH combined with external hemorrhoids cuttingstripping surgery and traditional Milligan-Morgan surgery in the treatment of circumferential mixed hemorrhoids HUANG Guo-feng；QIU Guang-ming；ZHOU Ming-zhu Objective To compare the effect of procedure for prolapse and haemorrhoids(PPH)combined with external hemorrhoids cutting-stripping surgery and traditional Milligan-Morgan surgery in the treatment of circumferential mixed hemorrhoids.Methods A total of 62 patients with circumferential mixed hemorrhoids who were treated in our hospital from April 2014 to April 2016 were enrolled in and divided into observation group and control group according to different treatment methods,with 31 patients in each group.Patients in the observation group were treated with PPH combined with external hemorrhoids cutting-stripping surgery,while patients in the control group were treated with traditional Milligan-Morgan surgery.The clinical pathophysiological parameters,effect and postoperative complication rate of two groups were compared.Results Operation time,intraoperative blood loss,postoperative pain time;using times of postoperative 36 h anesthesia drug and hospital stay time in the observation group was significantly less than that in the control group(P＜0.01).VAS score of after surgery in both groups was significantly lower than that on the day before(P＜0.01)and VAS score of in the observation group was significantly lower than that in the control group at simultaneous stage(P＜0.01).Total effective rate of the observation group was 93.5%,which was significantly higher than 71.0%of the control group;while postoperative complication rate of the observation group was 12.9%,which was significantly lower than 38.7%of the control group(P＜0.05).Conclusion PPH combined with external hemorrhoids cutting-stripping surgery has the advantages of less trauma,sooner reconery,less pain and postoperative complication compared with Milligan-Morgan surgery in the treatment of circumferential mixed hemorrhoids. 2017 Vol. 24 (3): 54-57 [Abstract] ( 150 ) HTML (38 KB)  PDF  (0 KB)  ( 34 ) 58 Effect and its postoperative recovery influence of laparoscopic in the treatment of colorectal cancer HE Zhi-gang；HE Yong-zhong；KONG Fan-dong；DU Han-peng；WU Ming-jian Objective To explore the clinical effect of laparoscopic and laparotomy in the treatment of colorectal cancer and influence on incidence rate of postoperative intestinal obstruction.Methods From February 2013 to February 2016,90 patients with colorectal cancer in our hospital were divided into experimental group（60 cases）and control group（30 cases）according to the patients′willingness.Patients in the experimental group were treated by laparoscopic, patients in the control group were treated by laparotomy.Intraoperative conditions(operation time,intraoperative blood loss, length of incision),postoperative pain score and feel good rate and postoperative conditions(anal exhaust time,ambulation time,discharge time,intestinal obstruction incidence rate,total complication rate,recurrence and metastasis rate)between two groups were compared.Results Intraoperative blood loss and length of incision in the experimental group was significantly less than that in the control group(P＜0.05),operation time was slightly longer than that in the control group,and the difference was statistically significant(P＜0.05).Postoperative pain score in the experimental group was significantly lower than that in the control group(P＜0.05),feel good rate was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).Postoperative anal exhaust time,ambulation time,discharge time in the experimental group was significantly shorter than that in the control group(P＜0.05),and intestinal obstruction incidence rate,total complication incidence,recurrence and metastasis rate was less than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Laparoscopic in the treatment of colorectal cancer has less blood loss,smaller cut,shorter anal exhaust time,ambulation time and discharge time,lower intestinal obstruction incidence rate, total complication rate,recurrence and metastasis rate,and better clinical effect,witch is worth of promoting. 2017 Vol. 24 (3): 58-60 [Abstract] ( 136 ) HTML (37 KB)  PDF  (0 KB)  ( 35 ) 61 Effect comparison of different doses regimen of Desloratadine citrate disodium in the treatment of chronic urticaria HOU Qi-gang；TANG Li-qin Objective To compare the clinical effect of different dosage regimen of Desloratadine citrate disodium in treating chronic urticaria.Methods A total of 62 patients with chronic urticaria who were treated in our hospital from Jannary to June 2016 were enrolled in and divieded into observation group and control group according to random number table method,with 31 patients in each group.Patients in the observation group were given decremental treatment of Desloratadine citrate disodium,while patients in the control group were given conventional treatment.The clinical symptom score,clinical effect,level of serum IgE,adverse reaction rate and recurrence rate of two groups were recorded and compared.Results Clinical symptom scores of pruritus,wheal size,wheal number and duration after treatment in two groups were significantly lower than those before treatment(P＜0.01);after treatment,the difference in clinical symptom score between two groups was statistically significant(P＜0.05).The total effective rate of the observation group was 93.55%,which was significantly higher than that 74.19%of the control group,and the difference was statistically significant(P＜0.05).Level of IgE after treatment in two groups was all significantly lower than that before treatment(P＜0.01), there was no statistically significant difference in level of IgE between two groups(P＞0.05);4 weeks after withdrawal, level of IgE in the observation group was not significantly higher than that after treatment(P＞0.05),while level of IgE in the control group was significantly increased than that after treatment(P＜0.01),level of IgE in the observation group was significantly lower than that in the control group(P＜0.01).Incidence rate of adverse reactions in the observation group was 6.45%,in the control group with 9.68%,and the difference was not statistically significant(P＞0.05).Recurrence rate in the observation group was 19.35%,significantly lower than 48.39%in the control group,and the difference was statistically significant(P＜0.05).Conclusion The decremental treatment of Desloratadine citrate disodium can enhance effective rate,improve level of serum IgE and reduce recurrence rate. 2017 Vol. 24 (3): 61-63转67 [Abstract] ( 167 ) HTML (37 KB)  PDF  (0 KB)  ( 33 ) 64 Microbiological examination and treatment for prevention of hand open injury FAN Qi-zhu；LIN li-jun；WU Ting；LI Xiu-qi Objective To explore the application value of microbiological examination in the prevention of infection in patients with hand open injury.Methods 200 cases of hand open injury in our hospital from July 2011 to July 2016 were selected and divided into group A and group B by random number table method,each group of 100 cases.Patients in group A were given antibiotics in routine way after debridement,bacterial culture and drug sensitivity test were carried out in patients of group B before debridement according to monitoring results to carry our infection treatment.The results of laboratory tests were observed in patients with group B,and medication time,length of stay,wound infection rate and wound healing were compared between two groups.Results 69 cases of bacterial infection were found by laboratory examination in group B,and 81 strains of pathogenic bacteria were detected.Among them,65 strains(80.2%)were gram negative bacilli,15 strains(18.5%)were gram positive bacteria and 1 strain(1.2%)was fungi.Escherichia coli and Pseudomonas aeruginosa were the main pathogens in gram negative bacteria,and staphylococcus aureus in gram positive bacteria.Medication time,length of stay and wound healing in group B were significantly better than those in group A, with statistical significance(P＜0.05).Conclusion Microbiological examination before surgery in patients with hand open injury is helpful to identify the type of bacterial infection.Targeted use of antibiotics avoids the occurrence of local complications and promotes wound healing. 2017 Vol. 24 (3): 64-67 [Abstract] ( 160 ) HTML (36 KB)  PDF  (0 KB)  ( 31 ) 68 Effect of rehabilitation therapy in patients with chronic obstructive pulmonary disease during stable phase WU Ji-bing；ZHU Yun-ping；CHEN Ke Objective To explore effect of rehabilitation therapy in chronic obstructive pulmonary disease during stable phase.Methods 80 patients with chronic obstructive pulmonary disease(COPD)during stable phase treated in our community from March 2014 to September 2016 were randomly divided into two groups,each group 40 cases.Patients in control group were given drug treatment,while patients in observation group were given drug combined rehabilitation therapy,curative effect,improved pulmonary function,quality of survival,breathing improvement and activity endurance were compared between two groups.Results Treatment effective rate in the observation group was 92.50%,significantly higher than 82.50%in the control group,and the difference was statistically significant(P＜0.05).FVC,FEV1,FEV1%, FEV1/FVC after treatment in the observation group was better than that in the control group,and the difference was statistically significant(P＜0.05).COPD life quality evaluation scale,6 MWT,Borg scale,SGRQ scores after treatment in the observation group was better than that in the control group,and the difference was statistically significant(P＜0.05). Conclusion Rehabilitation therapy in chronic obstructive pulmonary disease during stable phase has significant effect, can improve lung function,improve sports ability and enhance quality of life,which has a positive clinical significance. 2017 Vol. 24 (3): 68-70 [Abstract] ( 144 ) HTML (34 KB)  PDF  (0 KB)  ( 36 ) 71 Application effect of progesterone sustained-released vaginal gel for luteal phase support in vitro fertilization and embryo transfer WANG Mei-xian；ZHANG Yang；SHAO Xiao-guang Objective To analyze the efficacy and safety of progesterone sustained-released vaginal gel for luteal phase support in vitro fertilization-embryo transfer(IVF-ET).Methods From January to December 2015,992 patients who were agreed on long-term regimen of IVF-ET were selected.According to different progesterone-support regimens,they were divided into group A(muscular injection progesterone 60 mg,n=56),group B(muscular injection progesterone 40 mg,n=740), and group C(external application of progesterone sustained-released vaginal gel,n=196).The pregnancy rate,implantation rate,multiple-gestation pregnancy rate,miscarriage rate,ectopic pregnancy rate and incidence of adverse drug reactions were compared among the three groups.Results There was no significant difference in pregnancy rate,implantation rate, multiple gestation pregnancy rate,miscarriage rate,orectopic pregnancy rate among the three groups(P＞0.05).However,the pregnancy rate,multiple gestation pregnancy rate and implantation rate had increasing tendency,and miscarriage rate was in a decrease tendency in group C.The total incidence of adverse drug reactions was significantly lower than that in the group A and B，the difference was statistically significant(P＜0.01).Conclusion Progesterone sustained-released vaginal gel is one of the effective and safe methods for luteal phase support in IVF-ET. 2017 Vol. 24 (3): 71-73 [Abstract] ( 167 ) HTML (29 KB)  PDF  (0 KB)  ( 32 ) 74 Levels of serum vitamin A in children with recurrent respiratory tract infection and its impact on immune function LIN Feng-ji Objective To analyze the changes of serum vitamin A levels in children with recurrent respiratory tract infection and its effects on immune function.Methods 100 cases of children with recurrent respiratory tract infection treated in our hospital from January 2014 to June 2015 were selected as the study group，and 100 healthy children in our hospital were taken as control group.The observation group was divided into observation group 1（n=40）and observation group 2（n=60）.Children in the observation group were treated with conventional anti-infective therapy and the observation group 1 received vitamin A supplementation in addition.The levels of vitamin A and immune function of children in the control group were measured by microfluorescence，flow cytometry and automatic biochemical analyzer. The total effective rate of clinical treatment and the levels of IgA，IgM and IgG before and after treatment were compared between observation group 1 and observation group 2.Results The levels of vitamin A,IgA，IgM and IgG in the observation group were significantly higher than those in the control group（P＜0.01）.The total effective rate of clinical treatment in the observation group 1 was significantly higher than that in the observation group 2（P＜0.01）. There was no significant difference in the levels of IgA，IgM and IgG before treatment between observation group 1 and observation group 2（P＞0.05）.After treatment，Serum levels of IgM，IgG and IgA in observation group 1 were significantly higher than those in the observation group 2（P＜0.01）.Conclusion Children with recurrent respiratory tract infection have a lower level of serum vitamin A than healthy children.Vitamin A supplementation therapy for children with recurrent respiratory tract infection can enhance children′s immune function,get more significant therapeutic effect. 2017 Vol. 24 (3): 74-76 [Abstract] ( 157 ) HTML (33 KB)  PDF  (0 KB)  ( 37 ) 77 Related factors for the nosocomial infections in children with the rotavirus diarrhea HU Dan Objective To explore the related factors for nosocomial infections in the children with rotavirus diarrhea in the study，and to provide theoretical basis for clinical diagnosis,treatment and prevention.Methods A total of 180 rotavirus diarrhea children with nosocomial infections who were treated in the hospital from October 2013 to October 2016 were enrolled in the study.A survey was conducted for age，gender，season，the nutritional status of children，hand hygiene of the children′s family members，disinfection of tableware，length of hospital stay.Results There was no difference in the incidence of the different gender groups of children（P＞0.05）.The difference in the incidence was statistically significant among the different age groups of children（P＜0.05），and the incidence of nosocomial infections was highest in children aged 7 and 12 months old.The difference in the incidence was statistically significant among the different season groups of children（P＜0.05），and the autumn(from September to November)was the peak.At the same time，the Logistic analysis showed that the risk factors for the nosocomial infections in the children with rotavirus diarrhea included the nutritional status of children，hand hygiene of the children′s family members，disinfection of tableware，length of hospital stay（P＜0.05）.Conclusion The children with rotavirus diarrhea aged between 7 and 12 month are at high risk of nosocomial infections，and the incidence is high in autumn（from September to November）.It can be an effective method to prevent and control the nosocomial infections that improving the nutritional status of children，hand hygiene of the children′s family members，disinfection of tableware，and shorten hospital stay. 2017 Vol. 24 (3): 77-79 [Abstract] ( 152 ) HTML (30 KB)  PDF  (0 KB)  ( 37 ) 80 Effect of Aspirin combining with Dydrogesterone in the treatment of habitual miscarriage XIAO Wan-sheng Objective To observe the clinical effect of Aspirin combining with Dydrogesterone in the treatment of patients with habitual miscarriage.Methods By a random number table,140 patients with habitual miscarriage accepted treatment in Department of Gynecology and Obstetrics of our hospital from August 2013 to September 2014 were evenly divided,with 70 cases in each group.In conventional group,regular human chorionic gonadotropin combined with progesterone was applied,while in combination group,Aspirin together with Dydrogesterone was adopted.The therapeutic effect was compared between the two groups.Results The rate of miscarriage,level of IFN-γ and D-dimer,and incidence of adverse reactions in the combination group were greatly lower than those in the conventional group.The values of PT and APTT,and IL-4 level were all remarkably increased in comparison with those in the conventional group(P＜0.05). Conclusion Combination of Aspirin and Dydrogesterone can obtain a definite effect on treating habitual miscarriage,and is beneficial to improve coagulation function and regulate immune status in a low risk of adverse reactions,which has the significance and value of promotion. 2017 Vol. 24 (3): 80-82 [Abstract] ( 152 ) HTML (32 KB)  PDF  (0 KB)  ( 42 ) 83 Effect of different drug combination aerosol inhalation in the treatment of pediatric asthmatic bronchitis LIU Peng Objective To compare the efficacy of combination aerosol inhalation of Budesonide Suspension combined with nebulized inhalation of Terbutaline Sulfate,Compound Ipratropium Bromide Solution for Inhalation in the treatment of pediatric asthmatic bronchitis.Methods Eighty children with asthmatic bronchitis in our hospital from January 2013 to August 2016 were randomly selected,and they were divided into group A and group B,with 40 patients in each group. Group A was given aerosol inhalation of Budesonide combined with Terbutaline;group B was given aerosol inhalation of Budesonide combined with Compound Ipratropium Bromide Solution for Inhalation.The therapeutic effect of asthmatic bronchitis was compared between two groups.Results The therapeutic effect of the group A(97.5%)was similar to that of the group B(95.0%),and the difference was not statistically significant(P＞0.05).The improved time comparison of cough,wheeze and lung signs after treatment of the two groups had no statistically significant difference(P＞0.05).Conclusion In the clinical treatment of pediatric asthmatic bronchitis,combination aerosol inhalation of inhaled Budesonide Suspension combined with aerosol solution of Terbutaline Sulfate,Compound Ipratropium Bromide Solution for Inhalation can significantly improve the clinical symptoms of children,which achieves better clinical effect and it is worthy of clinical promotion and application. 2017 Vol. 24 (3): 83-85 [Abstract] ( 140 ) HTML (34 KB)  PDF  (0 KB)  ( 35 ) 86 Relationship between high-risk HPV infection and cervical lesions GUO Fei-fei；NAN Bei-bei Objective To investigate the relationship between high-risk HPV infection and cervical lesions.Methods A total of 9672 patients with cervical cancer who were screened by HPV method in Dalian Wafangdian Women and Children′s Hospital from January to December in 2015 were selected as research subjects,and the relationship between high-risk HPV infection and cervical lesions was analyzed.Results 8741 cases were HPV negative,and 931 cases were HPV positive.24 cases were low-grade lesions diagnosed by cervical biopsy,93 cases were cervical high-grade lesions, 1 case was high-grade lesion with suspected invasive carcinoma,and 1 case was cervical squamous cell carcinoma;the educational background and incidence rate of vaginitis in patients with HPV positive were significantly higher than those in patients with HPV negative,and the differences were significant(P＜0.01).HPV 16,18 and 52 were most likely to cause cervical lesions.Conclusion There is a close relationship between high-risk HPV infection and cervical precancerous lesions and cervical cancer.HPV 16,18 and 52 are the main infection factors in the high-risk HPV infection. Test of high-risk HPV infection has diagnostic significance in the screening of cervical cancer. 2017 Vol. 24 (3): 86-88转100 [Abstract] ( 112 ) HTML (34 KB)  PDF  (0 KB)  ( 34 ) 89 Retrospective analysis of intravenous immunoglobulin in the treatment of severe neonatal pneumonia ZHANG Ya-wei；KANG Wen-qing；XIONG Hong；XU Bang-li；ZHANG Yao-dong；LI Zhao-hui；WANG Ying-yuan；LIU Da-peng；ZHENG Li-juan Objective To discuss the clinical effect of intravenous immunoglobulin(IVIG)in the treatment of severe neonatal pneumonia and complications.Methods Clinical data of 160 hospitalized newborn with severe pneumonia in our hospital from May 2012 to May 2014 were retrospectively analyzed.Patients were divided into IVIG group(81 cases)and control group(79 cases).The therapeutic effects,dyspnea time,length of stay in hospital,duration of mechanical ventilation,and complications between the two groups were compared.Results Compared with the control group,the dyspnea time,duration of hospital stay and mechanical ventilation time were significantly shorter,the effective rate was improved in the IVIG group,the differences were statistically significant(P＜0.05).The incidence of pleural effusion and atelectasis were obviously lower in the IVIG group than that in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in respiratory failure and hepatic function damage between the two groups(P＞0.05).Conclusion IVIG is effective in the treatment of severe neonatal pneumonia,and with few complications. 2017 Vol. 24 (3): 89-91 [Abstract] ( 132 ) HTML (34 KB)  PDF  (0 KB)  ( 30 ) 92 Clinical study of Montelukast Sodium in the treatment of pediatric allergic purpura LIN Dong-li；LIN Dao-huang；XIE Shao-jun Objective To discuss the clinical effect of Montelukast Sodium in the treatment of pediatric allergic purpura. Methods Seventy children with pediatric allergic purpura in the Department of Pediatrics of People′s Hospital of Chenghai District in Shantou City were selected from May 2014 to May 2016.All the children were confirmed by clinical examination and accorded with the relevant diagnostic criteria of pediatric allergic purpura,they were divided into conventional group and treatment group,with 35 cases in each group.The conventional group was given the routine treatment,and the treatment group was given the Montelukast Sodium based on the treatment of conventional group.The therapeutic effect,time of skin purpura disappeared,the incidence of adverse reactions differences were compared.Results The effective rate of the treatment group was 97.1%,and the conventional group was 85.7%,the treatment group was significantly higher than that of conventional group,the difference was statistically significant(P＜0.05);and the time of skin purpura disappearance,joint pain disappeared,and the disappearance time of digestive tract disease[(4.9±1.9),(4.1±1.6),(4.2±1.3) d]was significantly shorter than that of the conventional group[(6.8±2.1),(6.3±2.3),(5.7±1.6)d],the difference was statistically significant(P＜0.05);there was no serious adverse reactions in the two groups in the course of treatment.Conclusion Montelukast Sodium on the basis of conventional drug therapy can effectively improve the therapeutic effect, shorten the treatment time of children and promote their early recovery,it has very important clinical significance,worthy of promotion and application. 2017 Vol. 24 (3): 92-94 [Abstract] ( 138 ) HTML (35 KB)  PDF  (0 KB)  ( 41 ) 95 Clinical Effect of Cyproterone acetate assisted hysteroscopic endometrial polypectomy for endometrial polyp LI Ji-mei；YOU Jin-hua；JIAO Hai-hua Objective To explore clinical effect of Cyproterone acetate assisted hysteroscopic endometrial polypectomy for endometrial polyps.Methods 88 patients with endometrial polyps treated in our hospital from March 2013 to March 2015 were randomly divided into control group and observation group by using a computer to generate a random number table,44 cases in each group.Patients in the control group were treated with hysteroscopic endometrial polypectomy treatment,while patients in the observation group were given with Cyproterone acetate assisted hysteroscopic endometrial polypectomy.Followed up for 12 months after treatment,endometrial thickness changes,menstrual blood loss score (PBAC score),normal menstrual cycle and recurrence during follow-up of two groups were compared before and after treatment.Results Before treatment,there was no statistical difference in endometrial thickness of two groups(P＞0.05); after treatment,endometrial thickness changes in two groups were better than that before treatment(P＜0.05),3,6,and 12 months after treatment,endometrial thickness in the observation group was lower than that in the control group(P＜0.05). Before treatment,there was no statistical difference in PBAC score of two groups(P＞0.05);after treatment,PBAC score of two groups was decreased with time(P＜0.05),3,6,12 months after treatment,PBAC score in the observation group score was lower than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,normal rate of menstrual cycle in two groups showed a ladder improvement(P＜0.05),and normal rate of menstrual cycle in the observation group was higher than that in the control group(P＜0.05)3,6,12 months after treatment.During follow-up,recurrence rate of the control group was 18.2%,which was higher than 2.3%of the observation group,and the difference was statistically significant(P＜0.05).Conclusion Cyproterone acetate assisted hysteroscopic endometrial polypectomy for endometrial polyps has a good effect,can reduce recurrence rate of endometrial polyps,it is worth clinical promotion. 2017 Vol. 24 (3): 95-97 [Abstract] ( 162 ) HTML (33 KB)  PDF  (0 KB)  ( 43 ) 98 Effect of low molecular heparin in the treatment of neonatal septicemia DU Pei-zhen；PAN Wen-zhong；LIAO Pei-na Objective To investigate effectiveness of low molecular heparin in the treatment of neonatal sepsis.Methods 58 cases of neonatal septicemia in our hospital from March 2015 to July 2016 were collected and divided into observation group and control group according to admission order,29 cases in each group.Patients in the control group were treated by traditional antibiotic treatment,patients in the observation group were treated with low molecular heparin on the basis of the control group,clinical therapeutic effect,changes of procalcitonin(PCT)and C reactive protein(CRP) levels before and after treatment between two groups were compared.Results Total effective rate in the observation group was 96.55%,higher than 86.21%in the control group,and the difference was statistically significant(P＜0.05).PCT and CRP level after treatment in the observation group was(0.29±0.17)ng/L and(5.52±2.37)mg/L respectively,significantly lower than(5.65±2.18)ng/L and(22.70±5.29 mg/L before treatment(P＜0.05);PCT and CRP level after treatment in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Low molecular heparin combined antibiotics in the treatment of neonatal sepsis has obvious clinical effect,can significantly improve procalcitonin and CRP level,which has high clinical value. 2017 Vol. 24 (3): 98-100 [Abstract] ( 154 ) HTML (31 KB)  PDF  (0 KB)  ( 33 ) 101 The effect of Gatifloxacin treating retreatment pulmonary tuberculosis QU Zhi-jun；LI Guo-hang；ZHUANG Gui-long；YU Xi；ZHU Nan-lan Objective To explore the clinical effect of Gatifloxacin treating retreatment pulmonary tuberculosis.Methods 100 cases with retreatment pulmonary tuberculosis treated by our hospital from January 2013 to March 2016 were selected as the research objects and they were randomly divided into two groups by taking the computer random sequence method,each group had 50 cases.The control group received routine anti tuberculosis treatment,while the observation group received Gatifloxacin treatment on the basic of routine anti tuberculosis treatment.The negative conversion rate of sputum bacterium,the total absorption rate of the focus,the incidence rate of adverse reaction and immune function indexes were compared between two groups.Results The negative conversion rate of sputum bacterium,the total absorption rate of the focus in the observation group were significantly higher than those in the control group(P＜0.05),and the incidence rate of adverse reaction was significantly lower than that in the control group(P＜0.05).Compared with before treatment,the immune function indexes in the two groups after treatment were decreased significantly(P＜0.05),but the immune function indexes in the observation group after treatment were higher than those in the control group(P＜0.05).Conclusion Gatifloxacin treating retreatment pulmonary tuberculosis has significant clinical effect,and can effectively promote the sputum bacterium for negative-conversing and the absorption of focus,but also can reduce the adverse reaction,improve immune function. 2017 Vol. 24 (3): 101-103 [Abstract] ( 119 ) HTML (32 KB)  PDF  (0 KB)  ( 33 ) 104 Influence of different doses of Atorvastatin on cardiac function and blood lipid index in patients with coronary artery disease after percutaneous coronary intervention and their safety evaluation JIANG Yu；BI Hui Objective To study the effect of different doses of Atorvastatin on cardiac function and blood lipid index in patients with coronary artery disease(CAD)after coronary intervention as well as their safety.Methods 100 patients with CAD undergone percutaneous coronary intervention(PCI)in our hospital from January to December 2015 were selected as research objects.By a random number table method,they were randomly divided into conventional(n=50)and highdose group(n=50).After surgery,they were both provided with Atorvastatin at a dose of 20 mg once per day(conventional dose group)and 40 mg once per day(high dose group).The course of treatment was lasted for one month.The cardiac function,blood lipid and drug safety between the two groups were compared.Results Before treatment,there was no difference in each index of cardiac function between the two groups(P＞0.05).After therapy,the left ventricular end systolic volume index(LVESVI)and left ventricular end diastolic volume index(LVEDVI)in the high dose group were both significantly lower than those in the conventional dose group,the left ventricular ejection fraction(LVEF)was higher in comparison with that in the conventional dose group,which were all displayed statistical difference(P＜0.05).No difference was found in each index of blood lipid before treatment in both groups(P＞0.05).After PCI,the total cholesterol (TC)and low density lipoprotein cholesterol(LDL-C)were both obviously lower than those in the conventional dose group with statistical difference(P＜0.05).With regards to adverse reactions,there were vertigo in one case,digestive tract reaction in two cases,and increase of urea nitrogen in one case in the high dose group,and the total incidence of adverse reactions was 8.0%.In the conventional dose group,one case was occurred with vertigo,one was digestive tract reaction, and one case with the increase of urea nitrogen.The total incidence of adverse reactions was 6.0%,which was not displayed difference after comparison(P＞0.05).Conclusion Atorvastatin can effectively improve cardiac function and blood lipid index after PCI in patients with CAD.The effect is better if used in a high dose of the drug with better safety, which is worthy of clinical promotion and application. 2017 Vol. 24 (3): 104-106 [Abstract] ( 132 ) HTML (32 KB)  PDF  (0 KB)  ( 33 ) 107 Clinical effect observation of Rosuvastatin combined with Clopidogrel in the treatment of unstable angina pectoris WANG Yan-wu Objective To observe the clinical efficacy of Rosuvastatin combined with Clopidogrel in the treatment of unstable angina pectoris.Methods Sixty patients with unstable angina pectoris treated in our hospital from January 2014 to January 2016 were selected as research objects.All patients were divided into observation group(n=30)and control group (n=30)by a random number table method.In the control group,conventional drugs for symptomatic treatment like oral administration of aspirin,nitrates,β-blockers,calcium antagonists,and low molecular weight heparin,etc.were used,while in the observation group,Rosuvastatin and Clopidogrel were added on the basis of the control group.The total effective rate after treatment,frequency of angina pectoris attack before and after treatment,number of myocardial ischemia and the total duration of myocardial ischemia were compared between the two groups.Results The total effective rate of the observation group was 96.7%,and that of the control group was 76.7%,and the total effective rate of the two groups was statistically significant(P＜0.05).Frequency of angina pectoris attack,number of myocardial ischemia and the total duration of myocardial ischemia were greatly reduced in comparison with those before treatment,and decrease in the observation group was more obvious compared with those in the control group with statistical difference(P＜0.05).Conclusion Rosuvastatin combined with Clopidogrel in treatment of unstable angina pectoris is safe,which can improve the curative effect and alleviate the clinical symptoms,and is worthy of clinical promotion. 2017 Vol. 24 (3): 107-109 [Abstract] ( 123 ) HTML (31 KB)  PDF  (0 KB)  ( 27 ) 110 Effect observation of Nifedipine treating threatened premature labor ZHU Ping Objective To explore the clinical effect of Nifedipine treating threatened premature labor.Methods 80 pregnant women with threatened premature labor treated by our hospital from June 2014 to June 2016 were selected as research objects and they were divided into observation group(n=40)and control group(n=40)using the random number table method.The observation group was treated by Nifedipine,while the control group was treated by Magnesium Sulfate.The curative effect and the incidence rate of adverse reaction between two groups were compared.Results The success rate of tocolysis in the observation group was 77.5%,and it was 75.0%in the control group,and the two groups had no statistical difference(P＞0.05).The incidence rate of adverse reaction in the observation group(15.0%)was significantly lower than that of the control group(40.0%)(P＜0.05).The rate of extension time of gestational week＞48 h and＞7 d in the observation group was 30.0%,45.0%respectively,and it was 27.5%,42.5%respectively in the control group,and the difference between the two groups in the prolongation of the gestational age was not statistically significant(P＞0.05). Conclusion The effect of Nifedipine and Magnesium Sulfate treating threatened premature laboris similar,but the adverse reaction is fewer for Nifedipine,and it has no adverse effects on the newborn,and in can be used as the choice drug treating threatened premature labor. 2017 Vol. 24 (3): 110-111转148 [Abstract] ( 134 ) HTML (29 KB)  PDF  (0 KB)  ( 40 ) 112 Application and clinical observation of multi-purpose refiner in smashing White Mustard Seed of moxibustion medicine XUAN Zhao-yin；XIN Zhen-jie；LIAO Yu-ming；CHEN Zong-wu；ZHONG Zhi-bing；LUO Xing Objective To explore the application and clinical observation of the multi-purpose refiner in smashing White Mustard Seed of moxibustion medicine.Methods 80 tested volunteers who had no skin allergy in June 2014 in our hospital were selected and divided into the control group A and the treatment group A according to the random number table method.The control group A was applied the moxibustion thick paste made with the traditional method in the relevant acupoint,the treatment group A was applied the moxibustion thick paste made with the multi-purpose refiner in the same acupoint.The skin irritation,onset time and fever degree of the two groups were observed.In addition,160 patients with deficiency and cold type asthma in our hodpital in July and August from 2014 to 2016 were selected and divided into the control group B and the treatment group B according to the random number table method.The control group B was applied the moxibustion thick paste made with the traditional method in the relevant acupoint,the treatment group B was applied the moxibustion thick paste made with the multi-purpose refiner in the same acupoint.The treatment effect was compared between the two groups.Results The reaction average scores at 1,24,48,and 72 h in the treatment group A was higher than that in the control group A,with significant difference(P＜0.05).The onset time of human skin in the treatment group A was shorter than that in the control group A,and the fever degree in the treatment group A was stronger than that of the control group A,with significant difference(P＜0.05).The total effective rate in the treatment group B was 91.25%,which was higher than that in the control group B(77.50%),with significant difference (P＜0.05).Conclusion The moxibustion thick paste made with the multi-purpose refiner has a strong stimulation in human skin and has high curative effect for deficiency and cold type asthma in clinic,it is worthy of clinical promotion and application. 2017 Vol. 24 (3): 112-114 [Abstract] ( 120 ) HTML (35 KB)  PDF  (0 KB)  ( 36 ) 115 Study on quality standard of Tongqiao Erlong Pills WANG Yi-chun；TANG Qiu-zhu Objective To establish quality control standards for Tongqiao Erlong Pills.Methods Microscopical identification was used to qualitative of material medcine prescription,thin layer chromatography(TLC)method were established to identify Bupleuri Radix and Gentianae Radix et Rhizoma,gentiopicroside was determined by HPLC with Phenomenon Luna C18column(4.6 mm×250 mm,5 μm)used with the mobile phase of mthanol-water(25∶75)at a flow rate of 0.8 ml/min.The detecting wavelength was 270 nm,the column temperature was 35℃.Results Microscopic identification features were exclusive.The spots of TLC were clear and the negative control without interference.The linear range of gentiopicroside was 0.091-0.912 μg（r=0.9999,n=6）with a great linear relationship.The mean recovery rates were 99.9%(n=6),RSD equal to 1.2%.Conclusion This method is simple,rapid,reproducible,precise,reliable and accurate.It can be used for the quantification of Tongqiao Erlong Pills. 2017 Vol. 24 (3): 115-119 [Abstract] ( 143 ) HTML (42 KB)  PDF  (0 KB)  ( 35 ) 120 Influence of lipopolysaccharide(LPS)with low dosages on the secretion of IL-17 in T cells from asthma mice LEI Sheng-qin；HU Shui-ting；CHENG Li；HUANG Xiao-yan Objective To explore the influence of LPS with low dosage on the secretion of IL-17 and the potential mechanism.Methods The asthma mouse model was copied successfully and the T cells from spleen were isolated and cultured in vitro,and the mice were divided into the control group and the LPS group.The mice in LPS group were divided into the LPS group 1 and the LPS group 2,and were stimulated with 1,2 ng/ml LPS respectively for 72 hours.The control group was stimulated with the same volume of saline.The concentrations of IL-17 in the supernatant were detected with ELISA,the change of concentration of IL-17 was observed.Results After stimulation with lower dosages of LPS,the secretion of IL-17 in the supernatant decreased significantly in the LPS groups than that in the control group, with significant difference(P＜0.01).Conclusion Low dosage of LPS can inhibit the secretion of IL-17 in T cells of asthma,and it may be related with immune tolerance. 2017 Vol. 24 (3): 120-122 [Abstract] ( 131 ) HTML (33 KB)  PDF  (0 KB)  ( 41 ) 123 Influence of Silicone Gel on the expression of vascular endothelial growth factor of scar model in minipig LI Ding-ling；GAO Yan-chen；NONG Xiao-lin Objective To study the influence of Silicone Gel on the expression of vascular endothelial growth factor (VEGF)in scar model on the back of miniature pig and to explore the mechanism of action of medical Silicone Gel. Methods From July to September in 2015,the minipig back scar model was constructed and were randomly divided into the control group and the Silicone Gel group.The Silicone Gel group was given Medical Silicone Gel Spray after operation for 28 days,the control group was not treated.The animals were sacrificed after operation at 56 days,and the scar of pig back was removed.The changes of VEGF was observed by immunohistochemistry.Results Scar hyperplasia in the Silicone Gel group was significantly reduced,compared with the blank control group.The average optical density of VEGF in the Silicone Gel group was 0.034±0.081,which was lower than 0.110±0.014 in the the control group,with significant difference(P＜0.05).Conclusion Silicone Gel may reduce scar hyperplasia by down-regulation of VEGF. 2017 Vol. 24 (3): 123-125 [Abstract] ( 134 ) HTML (30 KB)  PDF  (0 KB)  ( 32 ) 126 The disappeared Streptococcus pneumoniae in positive blood culture flask ZHOU Shi-juan Objective To explore how to identify the disappeared Streptococcus pneumoniae in positive blood culture flask.Methods By targeted DNA sequencing(16S rRNA gene amplification),the disappeared bacterium was finally identified.Results The disappeared bacterium was identified as Streptococcus pneumoniae.Conclusion By targeted DNA sequencing(16S rRNA gene amplification)identification can detect the Streptococcus pneumoniae dead due to autolysis.It is indicated that in the process of bacteriological examination,smear and transmission to plate combined with growth curve and smear results of blood culture are performed right away after blood culture being positive.Together with growth curve of blood culture and outcomes of smear staining,further analysis is needed in order to increase positive detection rate of blood culture and reduce occurrence of report in fail and mistake. 2017 Vol. 24 (3): 126-128 [Abstract] ( 109 ) HTML (35 KB)  PDF  (0 KB)  ( 27 ) 129 Detection significance of glycosylated hemoglobin and serum lipids in patients with diabetes mellitus complicated with coronary heart disease XIAO Chun-jie Objective To investigate significance of glycosylated hemoglobin and serum lipids detection in patients with diabetes mellitus complicated with coronary heart disease.Methods A total of 185 patients with type 2 diabetes mellitus in Department of Endocrinology of the hospital were selected from June 2015 to June 2016.Among them,98 patients with type 2 diabetes mellitus complicated with coronary heart disease were selected as complication group and 87 patients with simple type 2 diabetes mellitus as diabetes group,and then 60 healthy people for physical examination at the same period in the hospital were selected as control group.The levels of TC,TG,LDL-C,HDL-C,APOA-I,APOB,HbA1c were analyzed statistically.80 patients were randomly selected from 185 patients with type 2 diabetes mellitus,the fasting blood glucose level≥11.10 mmol/L was taken as group A,7.0 mmol/L≤fasting blood glucose level＜11.10 mmol/L as group B,relationship between blood glucose and blood lipid was analyzed.Results The level of TC,TG,LDL-C,APOB and HbA1c in the diabetic group and the complication group was significantly higher than that in the control group;the levels of HDL-C and APOA-Ⅰwas significantly lower than that in the control group;the levels of TG,HDL-C and HbA1c in the complication group was significantly higher than that in the diabetic group,there was significant difference between two groups(P＜0.05).The levels of TG in group A was significantly higher than that in group B[(2.76±1.32) mmol/L vs.(1.93±1.06)mmol/L](P＜0.05).APOB was significantly higher than that in group B[(1.34±0.19)g/L vs.(1.18± 0.23)g/L],there was significant difference(P＜0.05).Conclusion TG,HDL-C and HbA1c are the predictors of the development of type 2 diabetes mellitus patients with coronary heart disease.The patients with higher blood glucose levels are more prone to abnormal lipid metabolism,which may lead to vascular endothelial dysfunction.Therefore,strict control of type 2 diabetic patients mellitus with blood glucose,blood lipid levels,can play an important role in delaying and preventing coronary heart disease. 2017 Vol. 24 (3): 129-131 [Abstract] ( 144 ) HTML (32 KB)  PDF  (0 KB)  ( 41 ) 132 Changing pattern of antibiotic resistance in Acinetobacter baumannii isolates during 2011-2015 ZHANG Peng；SONG Xiao-hai；LIU Jun Objective To investigate changing of antibiotic resistance in Acinetobacter baumannii(A.baumannii)isolates in The Third People′s Hospital of Dalian City.Methods A total of 987 clinical strains of A.baumannii were collected during 2011-2015.Bacteria identification and antimicrobial susceptibility testing were performed for these strains.Results The resistance rate of A.baumannii to the common antimicrobial agents increased,especially to Imipenem.Conclusion The antimicrobial resistance of A.baumannii is becoming more and more serious,appropriate control measures should be taken to regulate the clinical use of drugs,to use antibiotics rationally,to prevent the growth of drug-resistant strains,and to prevent hospital infection. 2017 Vol. 24 (3): 132-134 [Abstract] ( 115 ) HTML (31 KB)  PDF  (0 KB)  ( 37 ) 135 Bacterial flora distribution and antibiotic resistance analysis for deep fungal infections of clinical patients LIU Bo Objective To explore the distribution and antimicrobial resistance of the fungal infection in clinical patients. Methods A total of 300 fungal culture specimens were randomly selected from October 2012 to October 2015,the strains were isolated,cultured,tested and tested for susceptibility to fungi.Fungi type,the distribution of fungi in various departments,anti-fungal drug resistance to fungi and other microbial data analysis and statistics.Results Among the 300 patients,the proportion of the patients over 55 years old was larger.The proportions of the fungi infection in the severe medicine and hematology were relatively large,and the proportions of the fungi infection in the encephalopathy and other departments were smaller.The proportion of Candida albicans and Candida glabrata were higher and the proportion of Cryptococcus neoformans was smaller.Therefore,fungal infection in the age,specimen type,sub-types of strains detected in different types and the proportion of different susceptibility results are different.Conclusion The distribution and drug resistance of the fungus in deep fungal infection are different. 2017 Vol. 24 (3): 135-137 [Abstract] ( 159 ) HTML (32 KB)  PDF  (0 KB)  ( 27 ) 138 Effect of GPR119 on lipid metabolism related gene expression CHEN Zhi-ping；WANG Lan-feng；HU Rong Objective To investigate the effects of overexpression of GPR119 on expression of genes related to lipid metabolism in THP-1 macrophages.Methods Expression vector GPR119,and transfected into THP-1 cells with phorbol ester(160 nmol/L,48 h)to differentiate into macrophages were constructed.NC group:the empty vector transfected into THP-1 Dil-oxLDL(50 g/ml)48 h;GPR119(H)group:over expression of GPR119 transfected with THP-1 Dil-oxLDL (50 g/ml)48 h.detection of lipid metabolism related genes expression in GPR119 transfected macrophages after THP-1. Results The expression of GPR119 in group SR-B1,APOE,LCAT gene expression were significantly higher than those of control group(P=0.000).Conclusion Over expression of GPR119 can cause changes in the expression of genes related to lipid metabolism. 2017 Vol. 24 (3): 138-139转142 [Abstract] ( 135 ) HTML (29 KB)  PDF  (0 KB)  ( 38 ) 140 Application effect analysis of urine routine examination and ultrasonography in the diagnosis of Acute appendicitis in children TONG Li-jun Objective To explore and analyze the application effect of urine routine examination and ultrasonography in the diagnosis of acute appendicitis in children.Methods 60 pediatric patients with acute appendicitis in our hospital from June 2014 to June 2016 were selected as research objects.According to a random number table,they were evenly divided into two groups,30 cases in each group.The control group was given ultrasonography,while the research group was applied urine routine examination.The therapeutic effect in the two groups was analyzed.Results The clinical diagnostic accuracy in the research group was 96.67%,significantly higher than that of control group accounting for 80.00% (P＜0.05).The score of parents'satisfaction in the research group was significantly higher than that of control group(P＜0.05).Conclusion Urine routine test can obtain a better effect in the diagnosis of acute appendicitis in children compared with ultrasonography. 2017 Vol. 24 (3): 140-142 [Abstract] ( 157 ) HTML (28 KB)  PDF  (0 KB)  ( 31 ) 143 Teaching graduate student curriculum"Material structure identification and characterization"through the NMR analysis of retusiusine A CAI Le；CAO Qiu-e；WEI Kun；DING Zhong-tao This paper describes the teaching of graduate student curriculum“Materia structural identification and characterization”through the NMR analysis of retusiusine A,which is a new compound isolated from Bulbophyllum retusiusculum.Retusiusine A contains benzene,oxygenated carbon and non-oxygenated carbon,and its NMR data are nonoverlapped and very suitable for NMR teaching content. 2017 Vol. 24 (3): 143-148 [Abstract] ( 122 ) HTML (42 KB)  PDF  (0 KB)  ( 42 ) 149 Application study of case-oriented standardized patients in nursing teaching rounds of the department of respiratory medicine CUI Xin-hao；WU Miao-xia；ZHANG Xin-xuan；DONG Xue-ning；HUANG Hui-xin；ZENG Li-li Objective To explore application effect of case-oriented standardized patients in nursing teaching rounds of the department of respiratory medicine.Methods 100 interns in the Department of Respiratory Medicine of our hospital from July 2015 to May 2016 were selected and divided into the control group and the experimental group according to the random number table method,50 cases in each group.The control group was given teaching rounds according to the conventional teaching methods,the experimental group was given case-oriented standardized patients,and the teaching rounds were conducted once a week.After a month,the examinations were taken uniformly,so that the comparison of effects could be made.Results The examination results of theory and the operation in the experimental group was better than that in the control group,with significant difference(P＜0.01).The score of each item of nursing teaching rounds in the experimental group was better than that in the control group,with significant difference(P＜0.01).Conclusion The method of applying case-oriented standardized patients in respiratory medicine is superior to the routine teaching round-ward,which is helpful to improve the effect of teaching rounds,it is worthy of promotion and application. 2017 Vol. 24 (3): 149-151 [Abstract] ( 138 ) HTML (32 KB)  PDF  (0 KB)  ( 28 ) 152 Application effect of CBL combined with CP teaching method in gynecology and obstetrics clinical practice teaching CAI Guo-qing；ZOU Wei；ZHANG Xiao-hong；CHEN Bi-liang；WANG Jian；YANG Hong Objective To compare the application effect of CBL combined with CP teaching method and multimedia teaching in gynecology and obstetrics teaching.Methods 182 undergraduate students in our department from May to September in 2015 were selected and randomly divided into the experimental group(92 cases)and the control group (90 cases).The experimental group was given CBL combined with CP teaching method,while the control group was given CP teaching method.After teaching,examination and questionnaire investigation were used to evaluate.Results Both of case analysis scores and clinical operating results,the total results in the experimental group was better than that in the control group,with significant difference(P＜0.05).The satisfaction degree in improving learning interest,doctor-patient communication,teamwork,problem-solving,clinical thinking ability,clinical practice in the experimental group was higher than that in the control group,with significant difference(P＜0.01).Conclusion CBL combined with CP teaching method can enhance teaching effect. 2017 Vol. 24 (3): 152-154 [Abstract] ( 161 ) HTML (31 KB)  PDF  (0 KB)  ( 35 ) 155 Practice research on the construction of training base for nursing students in the Vocational College of Health Sciences,Guangzhou Medical Unviersity WANG Xiao-qin Objective To study the requirements of nursing students in the Vocational College of Health Sciences, Guangzhou Medical Unviersity,to analyze the practical condition on the construction of training bases in the college. Methods From April 2011 to April 2012,the training base was not constructed in our college as conventional group, from May 2012 to May 2015,the training base was constructed as innovation group,80 cases in each group.According to the vocational education characteristics and arrangement of nursing courses,it was necessary to make a reform on the teaching methods,introduce the new teachers and standardize the management,the school on the basis of nursing practice base construction was putted forward.The student′s practical skills before and after construction of training bases were observed.Results The evaluation score of the student′s basic operation ability for innovation group was higher than that of conventional group(P＜0.01);the satisfaction of innovation group was higher than that of conventional group(P＜0.01).Conclusion For the work of the school practice base construction,can be combined with other colleges and universities demonstration site for reference,comprehensively improve the hardware and software facilities,the introduction of teachers,reform in college,emphasis should be focused on improving students practical ability,and most of the students for the college is satisfied with the arrangements. 2017 Vol. 24 (3): 155-157 [Abstract] ( 124 ) HTML (34 KB)  PDF  (0 KB)  ( 28 ) 158 The teaching ideas and exploration of Diaphoretics in classroom ZHANG Ru-yi；YOU Qiu-yun Diaphoretics is the first chapter of pharmacology of Chinese materia medica in pharmacy specialty of medical colleges.Exterior syndrome is the most common syndrome in our lives,diaphoretics is used rather widely in our daily lives.In order to let the students master the content of this chapter,and apply it to the real life and TCM clinic.The author has made a research on the pharmacology of Chinese materia medica concerned with treatment for exterior syndrome and teaching methods,and discusses the classroom teaching of Diaphoretics here. 2017 Vol. 24 (3): 158-160 [Abstract] ( 109 ) HTML (32 KB)  PDF  (0 KB)  ( 33 ) 161 Brief analysis on teaching method of spectrum analysis course for pharmacy major WEI Liu-bin；SHI Ling-gao；LIAO Na；ZHANG Yi Spectrum analysis course as one of the most difficult courses to learn in pharmacy major aims at analyzing the compound structure by spectrum.The course mixes with other courses like instrumental analysis,pharmaceutical chemistry,organic chemistry,physical chemistry and so on.The course plays a unique role in cultivating application skills and innovation ability for medical elites.In the process of teaching practice,aspects including stimulation of learning interest,optimization of teaching contents,multimediateaching,multiple teaching approaches,and optimization of evaluation system were discussed and summarized,which improved teaching effect.Through learning the course,the abilities to analyze and solve problems are developed in medical students. 2017 Vol. 24 (3): 161-163 [Abstract] ( 152 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 164 Exploration on education thoughtof hospital pharmacy interns CHENG Zhi-hong；LIU Xu-dong；YE Li-tong；CHEN Cai-yun；FAN Long Objective To explore the effect of continuing-innovation teaching method on the practice of pharmacy interns and to cultivate qualified pharmacists.Methods Continuing-innovation teaching method was taken into teaching process and both the teachers and the pharmacy students were orientated to solve the problems actively,the quality-ensured feedback system was used to measure the teaching quality.Results Continuous improvement of the teaching system and optimization of teaching methods were proved to promote pharmacy students′subjective initiative in learning and effectively enhance the comprehensive ability of pharmacy students in elaborative faculty,rational use of medicines and work specification.Conclusion Continuing-innovation teaching method is critical for improvement of administration level and the efficiency in teaching,and the pharmaceutical talents will be qualified enough for the society. 2017 Vol. 24 (3): 164-166 [Abstract] ( 115 ) HTML (30 KB)  PDF  (0 KB)  ( 39 ) 167 Study of case report in clinical thinking development of pediatrics LI Xiao-hua；ZHANG Cheng-xin；SONG Dong-mei；FU Jun-xian；YANG Yi-nan；HUANG Ying-long Objective To explore the role of case report in pediatric clinical thinking development.Methods 100 clinical medical undergraduates who took part in clinical internship in our department from Inner Mongolia Medical University from July 2014 to August 2015 were selected and randomly divided into control group(n=50)and experimental group (n=50)according to different teaching methods.In the experimental group,case report for these participants was given, while in the control group,there was no case report requirement.Case test scores and departmental examination scores between two groups were compared.Results The excellent rate and qualified rate of test scores in the experimental group and the control group was 30%and 18%,and 68%and 58%respectively,the unqualified rate was 2%and 24% accordingly,the excellent rate and the qualified rate in the experimental group were significantly higher than those in the control group,and the failure rate in the former was greatly lower than that in the latter,test scores of the experimental group was significantly better than that of the control group,and the difference was statistically significant(P＜0.01). The excellent rate of departmental rotation examination scores was 62%and 28%in the experimental group and the control group in turn,the difference of epartmental rotation examination scores between two groups had statistical significance(P＜0.01).The average test score in the experimental group and control group was(76.62±4.82)scores and(68.28± 7.45)scores,and the average score of departmental rotation examination was(84.76±6.61)scores and(72.46±5.67) scores,the average test score and average score of departmental rotation examination in the experimental group were both higher than those in the control group with statistical difference(P＜0.05).Conclusion Case report can remarkably increase the excellent rate and qualification rate of test results,improve average test score and average score of departmental rotation examination as well as student′s clinical thinking ability. 2017 Vol. 24 (3): 167-169 [Abstract] ( 145 ) HTML (35 KB)  PDF  (0 KB)  ( 41 ) 170 Effect of time-efficient encouraging nursing on early rehabilitation effects in patients with COPD XING Zhan-min Objective To explore the effect of time-efficient encouraging nursing on the early rehabilitation effects in patients with chronic obstructive pulmonary disease(COPD).Methods 76 patients with COPD who were admitted to our hospital from August 2013 to August 2015 were randomly divided into the observation group and control group,38 cases in each group.The control group were given routine nursing intervention,and the observation group were given time-efficient encouraging nursing.The treatment compliance,pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),the ratio of actual value and the predicted value(FEV1%)]and blood gas indexes[partial pressure of arterial oxygen(PaO2),partial pressure of arterial carbon dioxide(PaCO2),hydrogen ion concentration index(pH)]were compared between two groups.Results The treatment compliance of the observation group was 84.21%,significantly higher than that of the control group of 57.89%(P＜0.05).After nursing intervention,FVC,FEV1, FEV1%lung function index of observation group were significantly higher than those of control group(P＜0.05).After nursing intervention,levels of pH and PaO2in the observation group were significantly higher than those in the control group(P＜0.05),while PaCO2was significantly lower than that in the control group(P＜0.05).Conclusion The application of time-efficient encouraging nursing in patients with COPD can significantly improve the treatment compliance and pulmonary function indexes of patients.The level of arterial blood gas can be restored.It is conducive to the early rehabilitation of patients and worthy of promotion. 2017 Vol. 24 (3): 170-172 [Abstract] ( 127 ) HTML (33 KB)  PDF  (0 KB)  ( 33 ) 173 Effect of nursing intervention on pulmonary functions and treatment compliance for elderly patients with bronchial asthma GAO Zhi-dan；LUO Zhang-ying；GUO Hui-ling Objective To investigate the effect of nursing intervention on pulmonary function and treatment compliance for elderly patients with bronchial asthma.Methods 60 cases of elderly patients with bronchial asthma who were treated in our hospital from February 2014 to November 2015 were randomly divided into control group and treatment group, 30 cases in each group.The control group was given with routine care,while,the treatment group was given with nursing intervention.The differences of lung functions,treatment compliance,1-year survival rate and nursing satisfaction degree between the two groups were compared.Results The post-treatment oxygen partial pressure,FEV1,FEV1/FVC in treatment group were higher than those of control group,with differences were significant(P＜0.01).The total compliance rate of treatment group was higher than that of control group,with difference was significant(P＜0.05).No significant difference was found between the 1-year survival rate of control group and treatment group(P＞0.05).The satisfaction rate of treatment group was higher than that of control group,with difference was significant(P＜0.05).Conclusion Nursing intervention can improve lung functions,treatment compliance and the nursing satisfaction degree for elderly patients with bronchial asthma. 2017 Vol. 24 (3): 173-175 [Abstract] ( 148 ) HTML (35 KB)  PDF  (0 KB)  ( 31 ) 176 Effect of comprehensive nursing intervention on cognitive behavior and delivery outcome of pregnant women DENG Jie Objective To explore the influence of comprehensive nursing intervention on cognitive behavior and delivery outcome of pregnant women.Methods Pregnant women accepted antenatal examinations and admission delivery in our hospital from June 2015 to June 2016 were selected as the research objects and they were divided into control group and study group.Control group was given routine nursing,while study group was given comprehensive nursing intervention on the basis of control group.Cognition of delivery knowledge,delivery mode,stage of labor and neonatal condition between two groups were compared.Results After intervention,the good and excellent rate of cognition of delivery method in study group(57.89%)was significantly higher than that in control group(26.31%)(P＜0.05).The delivery mode in study group was significantly better than that in control group(P＜0.05).The natural childbirth in each total stage and the total stage of labor in study group were shorter than those of control group(P＜0.05).Apgar score in study group was significantly better than that in control group(61.06%)(P＜0.05).Conclusion The implementation of prenatal comprehensive nursing intervention can effectively improve the cognition of delivery,help to promote natural childbirth and shorten the childbirth process,which can effectively guarantee the maternal and infant health and improve the safety and it is worthy of popularization and application. 2017 Vol. 24 (3): 176-178转181 [Abstract] ( 135 ) HTML (34 KB)  PDF  (0 KB)  ( 38 ) 179 Feasibility analysis of nursing extension service for patients discharged from cervical cancer operation MOU Yu-lin Objective To analyze the feasibility of nursing extension service for patients discharged from cervical cancer operation.Methods Forty patients with cervical cancer who were treated and discharged from our hospital from January 2014 to February 2016 were selected as research objects.According to a random number table,they were evenly divided into control group and observation group,20 cases in each group.The control group was provided routine discharge guidance,while the observation group was additionally supplied nursing extension service on the basis of the control group.The self-care ability and quality of life at admission and six months after discharge in the two groups were compared.Results There was no significant difference in the quality of life scores between the two groups on admission(P＞0.05).The scores were both increased in the quality of life 6 months after discharge and the improvement of the quality of life scores in the observation group were significantly higher than that of control group(P＜0.05).There was no significant difference in the self-care ability between the two groups on admission.But 6 months after discharge,the scores of the index were significantly improved in both groups,and the improvement in the observation group was more remarkable compared with that in the control group(P＜0.05).Conclusion Nursing extension service can improve the quality of life in patients after cervical cancer operations and the self-care ability.It is more helpful for patients'rehabilitation and worthy of clinical application and promotion. 2017 Vol. 24 (3): 179-181 [Abstract] ( 123 ) HTML (30 KB)  PDF  (0 KB)  ( 36 ) 182 Influence of the international obstetric service model on primiparas′lateral episiotomy rate LUO Ling；ZHANG Xiao-yan；TANG Gui-hua；KONG Yue-xiang Objective To explore the influence of international obstetric service model on primiparas′lateral episiotomy rate.Methods 230 cases of primiparas who were treated in our hospital from February to July 2016 were selected and divided into control group(from February to April)and observation group(from May to July),115 cases in each group. The control group was treated with routine obstetric service model,while,the observation group was treated with the international obstetric service model on the basis of the conventional mode.The lateral episiotomy rate and nursing satisfaction degree of two groups were compared and analyzed.Results The lateral episiotomy rate of observation group was 26.08%,the control group was 69.57%,with significant difference(P＜0.05);the total nursing satisfaction degree of observation group was 98.26%,significantly higher than that of control group of 85.21%,with significant difference(P＜0.05). The factors that affected the lateral episiotomy included the lack of skilled young midwives,inadequate assessment of high-risk puerperas,puerperas′lack of maternal knowledge,medical intervention,lack of clinical supervision and the tension between doctors and patients.After delivery,the rate of perineal hematoma and perineal edema in observation group were significantly lower than those of control group(P＜0.05).Conclusion Application of international obstetric service model in primiparas significantly reduces the rate of episiotomyand greatly improves the satisfaction degree of puerperas and their families. 2017 Vol. 24 (3): 182-184 [Abstract] ( 157 ) HTML (33 KB)  PDF  (0 KB)  ( 39 ) 185 Effect analysis of nursing intervention on assisted reproductive technology in elderly women ZENG Han；WU Qiong-fang；CHEN Jing-jing Objective To evaluate the effect of humanistic nursing intervention in the process of assisting reproductive technology in elderly women.Methods From January to April in 2016,388 elderly infertile women accepted in vitro fertilization-embryo transplantation(IVF-ET)in our center were selected and were divided into observation group(n=200) and control group(n=188)based on the order of filing.In the control group,basic clinical nursing was provided such as regular health education guidance during ovulation induction,needling at night,and before and after egg retrieving and embryo transplantation and the like.The scores of self-rating anxiety scale(SAS)and self-rating depression scale(SDS), and questionnaire survey of patient′s satisfaction were carried out.In the observation group,SAS,SDS,and self-made questionnaire were measured during file-filling,needle-initiating,needling at night,egg retrieving,and embryo transplantation in order to know the psychological state and social demands of the patients during the treatment.After that,targeted mental nursing and health education guidance were adopted.The score of SAS and SDS,and patient′s satisfaction questionnaire after intervention measures were re-tested.The cycle cancellation rate,number of retrieved oocytes,the rate of high quality embryos,the clinical pregnancy rate,score of SAS and SDS,and questionnaire on patient′s satisfaction were observed in both groups.Results There was no great difference in the cycle cancellation rate,number of retrieved oocytes,the rate of high quality embryos or clinical pregnancy rate(P＞0.05).After intervention,the scores of SAS and SDS in the observation group were much lower than those in the control group(P＜0.05).The nursing satisfaction rate in the observation group(96%)was significantly higher than that in the control group accounting for 84%with statistical difference(P＜0.05).Conclusion For elderly female patients,in the process of performing with assisted reproductive technology,humanistic psychological nursing intervention can effectively relieve the psychological stress and improve patient′s satisfaction degree of treatment. 2017 Vol. 24 (3): 185-187转190 [Abstract] ( 114 ) HTML (38 KB)  PDF  (0 KB)  ( 30 ) 188 Application effect of good limb position placement in early rehabilitation nursing in patients with emiplegia due to cerebral apoplexy QIU Qing-qing；CAI Zhen-zhi；WEN Jin-feng；HU Xiao-hong Objective To explore the application effect of placement of good limb position in early rehabilitation in patients with hemiplegia due to cerebral apoplexy.Methods Forty patients with hemiplegia due to cerebral apoplexy from October 2015 to October 2016 in our hospital were selected and divided into observation group(n=20)and control group(n=20).In the control group,conventional treatment and nursing was used,while on the basis of the conventional treatment and nursing,good limb position design and placement was adopted on admission to the hospital in the observation group.The therapeutic effect,nursing satisfaction degree between the two groups were compared.Results After nursing,the score of daily life activity in both groups was obviously higher than that before nursing,and the score in the observation group was higher than that in the control group with statistical difference(P＜0.01).After nursing,the score of affected limb movement ability was both significantly higher than that before nursing.The score in the observation group was higher than that in the control group with statistical difference(P＜0.01).The nursing satisfaction rate in the observation group(97.50%)was greatly higher than that in the control group(85.00%)which was displayed great difference (P＜0.05).Conclusion The application of good limb placement in early rehabilitation of patients with hemiplegia due to cerebral apoplexy can improve the nursing effect and nursing satisfaction degree. 2017 Vol. 24 (3): 188-190 [Abstract] ( 136 ) HTML (31 KB)  PDF  (0 KB)  ( 29 ) 191 Comparative study of evidence-based nursing care and routine care to elderly patients with type 2 diabetes effect WANG Huang Objective To explore evidence-based nursing and regular care for elderly patients with type 2 diabetes care effect comparison.Methods 100 cases with type 2 diabetes from January to December 2015 in our hospital were randomly divided into control group and study group,50 cases in each group,the control group was received routine care,the study group was given evidence-based care,nursing effect of two groups were compared.Results The application effect of evidence-based nursing was significantly better than that of routine nursing,the total effective rate of the study group was 96.0%higher than that of control group of 60.0%(P＜0.05),and the nursing satisfaction rate of study group was 96.0%,higher than that of control group of 70.0%(P＜0.05).Conclusion Evidence-based care has a better effect in the application of clinical nursing elderly patients with type 2 diabetes,the clinical it should be popularized. 2017 Vol. 24 (3): 191-193转196 [Abstract] ( 132 ) HTML (37 KB)  PDF  (0 KB)  ( 40 ) 194 Research of psychological intervention on anxiety and depression in patients with cervical cancer WU Min Objective To investigate the influence of psychological intervention on anxiety and depression in patients with cervical cancer.Methods From January 2012 to September 2016,50 patients with cervical cancer treated in our hospital were randomly divided into the intervention group and the control group,and each group had 25 patients.The control group wast given with basic nursing,life care,health education and so on.The observation group was given the psychological intervention on the basis of the control group.According to the self-rating anxiety scale(SAS)and selfrating depression scale(SDS),SAS score and SDS score were observed before and after intervention in two groups,and the satisfaction with nursing service was also observed.Results After intervention,the intervention group and the control group of the SAS score[(35.72±7.23)points,(46.24±7.76)points]and the SDS score[(31.88±6.55)points,(45.24±5.62)points] were lower than those before intervention[(60.16±7.76)points,(59.56±8.01)points;(55.72±7.24)points,(56.96±7.72 points)],and the intervention group was lower than in the control group,the differences were statistically significant(P＜0.01).The nursing satisfaction rate of intervention group was 92.0%,which was higher than that of control group(68.0%), and the difference was statistically significant(P=0.034).Conclusion The psychological intervention can effectively relieve anxiety and depression in patients with cervical cancer,improve the degree of satisfaction with nursing service and the quality of life. 2017 Vol. 24 (3): 194-196 [Abstract] ( 120 ) HTML (32 KB)  PDF  (0 KB)  ( 35 )

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