枸地氯雷他定不同剂量方案治疗慢性荨麻疹的效果对比

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Abstract Objective To compare the clinical effect of different dosage regimen of Desloratadine citrate disodium in treating chronic urticaria.Methods A total of 62 patients with chronic urticaria who were treated in our hospital from Jannary to June 2016 were enrolled in and divieded into observation group and control group according to random number table method,with 31 patients in each group.Patients in the observation group were given decremental treatment of Desloratadine citrate disodium,while patients in the control group were given conventional treatment.The clinical symptom score,clinical effect,level of serum IgE,adverse reaction rate and recurrence rate of two groups were recorded and compared.Results Clinical symptom scores of pruritus,wheal size,wheal number and duration after treatment in two groups were significantly lower than those before treatment(P＜0.01);after treatment,the difference in clinical symptom score between two groups was statistically significant(P＜0.05).The total effective rate of the observation group was 93.55%,which was significantly higher than that 74.19%of the control group,and the difference was statistically significant(P＜0.05).Level of IgE after treatment in two groups was all significantly lower than that before treatment(P＜0.01), there was no statistically significant difference in level of IgE between two groups(P＞0.05);4 weeks after withdrawal, level of IgE in the observation group was not significantly higher than that after treatment(P＞0.05),while level of IgE in the control group was significantly increased than that after treatment(P＜0.01),level of IgE in the observation group was significantly lower than that in the control group(P＜0.01).Incidence rate of adverse reactions in the observation group was 6.45%,in the control group with 9.68%,and the difference was not statistically significant(P＞0.05).Recurrence rate in the observation group was 19.35%,significantly lower than 48.39%in the control group,and the difference was statistically significant(P＜0.05).Conclusion The decremental treatment of Desloratadine citrate disodium can enhance effective rate,improve level of serum IgE and reduce recurrence rate.

Key words： Desloratadine citrate disodium Conventional treatment Decremental treatment Chronic urticaria

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	HOU Qi-gang
	TANG Li-qin

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HOU Qi-gang,TANG Li-qin. Effect comparison of different doses regimen of Desloratadine citrate disodium in the treatment of chronic urticaria[J]. 中国当代医药, 2017, 24(3): 61-63转67.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I3/61

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