不同剂量阿托伐他汀对冠心病介入术后患者心功能、血脂指标的影响及其安全性评价

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Abstract Objective To study the effect of different doses of Atorvastatin on cardiac function and blood lipid index in patients with coronary artery disease(CAD)after coronary intervention as well as their safety.Methods 100 patients with CAD undergone percutaneous coronary intervention(PCI)in our hospital from January to December 2015 were selected as research objects.By a random number table method,they were randomly divided into conventional(n=50)and highdose group(n=50).After surgery,they were both provided with Atorvastatin at a dose of 20 mg once per day(conventional dose group)and 40 mg once per day(high dose group).The course of treatment was lasted for one month.The cardiac function,blood lipid and drug safety between the two groups were compared.Results Before treatment,there was no difference in each index of cardiac function between the two groups(P＞0.05).After therapy,the left ventricular end systolic volume index(LVESVI)and left ventricular end diastolic volume index(LVEDVI)in the high dose group were both significantly lower than those in the conventional dose group,the left ventricular ejection fraction(LVEF)was higher in comparison with that in the conventional dose group,which were all displayed statistical difference(P＜0.05).No difference was found in each index of blood lipid before treatment in both groups(P＞0.05).After PCI,the total cholesterol (TC)and low density lipoprotein cholesterol(LDL-C)were both obviously lower than those in the conventional dose group with statistical difference(P＜0.05).With regards to adverse reactions,there were vertigo in one case,digestive tract reaction in two cases,and increase of urea nitrogen in one case in the high dose group,and the total incidence of adverse reactions was 8.0%.In the conventional dose group,one case was occurred with vertigo,one was digestive tract reaction, and one case with the increase of urea nitrogen.The total incidence of adverse reactions was 6.0%,which was not displayed difference after comparison(P＞0.05).Conclusion Atorvastatin can effectively improve cardiac function and blood lipid index after PCI in patients with CAD.The effect is better if used in a high dose of the drug with better safety, which is worthy of clinical promotion and application.

Key words： Coronary heart disease;Interventional surgery Atorvastatin;Dose;Cardiac function;Blood lipid

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	JIANG Yu
	BI Hui

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JIANG Yu,BI Hui. Influence of different doses of Atorvastatin on cardiac function and blood lipid index in patients with coronary artery disease after percutaneous coronary intervention and their safety evaluation[J]. 中国当代医药, 2017, 24(3): 104-106.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I3/104

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