糖化血红蛋白及血脂在糖尿病合并冠心病中的检测意义

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Abstract Objective To investigate significance of glycosylated hemoglobin and serum lipids detection in patients with diabetes mellitus complicated with coronary heart disease.Methods A total of 185 patients with type 2 diabetes mellitus in Department of Endocrinology of the hospital were selected from June 2015 to June 2016.Among them,98 patients with type 2 diabetes mellitus complicated with coronary heart disease were selected as complication group and 87 patients with simple type 2 diabetes mellitus as diabetes group,and then 60 healthy people for physical examination at the same period in the hospital were selected as control group.The levels of TC,TG,LDL-C,HDL-C,APOA-I,APOB,HbA1c were analyzed statistically.80 patients were randomly selected from 185 patients with type 2 diabetes mellitus,the fasting blood glucose level≥11.10 mmol/L was taken as group A,7.0 mmol/L≤fasting blood glucose level＜11.10 mmol/L as group B,relationship between blood glucose and blood lipid was analyzed.Results The level of TC,TG,LDL-C,APOB and HbA1c in the diabetic group and the complication group was significantly higher than that in the control group;the levels of HDL-C and APOA-Ⅰwas significantly lower than that in the control group;the levels of TG,HDL-C and HbA1c in the complication group was significantly higher than that in the diabetic group,there was significant difference between two groups(P＜0.05).The levels of TG in group A was significantly higher than that in group B[(2.76±1.32) mmol/L vs.(1.93±1.06)mmol/L](P＜0.05).APOB was significantly higher than that in group B[(1.34±0.19)g/L vs.(1.18± 0.23)g/L],there was significant difference(P＜0.05).Conclusion TG,HDL-C and HbA1c are the predictors of the development of type 2 diabetes mellitus patients with coronary heart disease.The patients with higher blood glucose levels are more prone to abnormal lipid metabolism,which may lead to vascular endothelial dysfunction.Therefore,strict control of type 2 diabetic patients mellitus with blood glucose,blood lipid levels,can play an important role in delaying and preventing coronary heart disease.

Key words： Type 2 diabetes Coronary heart disease Glycated hemoglobin Lipids Apolipoprotein

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XIAO Chun-jie. Detection significance of glycosylated hemoglobin and serum lipids in patients with diabetes mellitus complicated with coronary heart disease[J]. 中国当代医药, 2017, 24(3): 129-131.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I3/129

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