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| Application effect of progesterone sustained-released vaginal gel for luteal phase support in vitro fertilization and embryo transfer |
| WANG Mei-xian ZHANG Yang SHAO Xiao-guang |
| Reproductive and Genetic Medicine Center of Dalian Women and Children Medical Center,Liaoning Province,Dalian 116000,China |
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Abstract Objective To analyze the efficacy and safety of progesterone sustained-released vaginal gel for luteal phase support in vitro fertilization-embryo transfer(IVF-ET).Methods From January to December 2015,992 patients who were agreed on long-term regimen of IVF-ET were selected.According to different progesterone-support regimens,they were divided into group A(muscular injection progesterone 60 mg,n=56),group B(muscular injection progesterone 40 mg,n=740), and group C(external application of progesterone sustained-released vaginal gel,n=196).The pregnancy rate,implantation rate,multiple-gestation pregnancy rate,miscarriage rate,ectopic pregnancy rate and incidence of adverse drug reactions were compared among the three groups.Results There was no significant difference in pregnancy rate,implantation rate, multiple gestation pregnancy rate,miscarriage rate,orectopic pregnancy rate among the three groups(P＞0.05).However,the pregnancy rate,multiple gestation pregnancy rate and implantation rate had increasing tendency,and miscarriage rate was in a decrease tendency in group C.The total incidence of adverse drug reactions was significantly lower than that in the group A and B，the difference was statistically significant(P＜0.01).Conclusion Progesterone sustained-released vaginal gel is one of the effective and safe methods for luteal phase support in IVF-ET.
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