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Quick Search     Adv Search 2021 Vol. 28, No. 32 Published: 2021-11-18   4 Expression levels of TAMs and PD-1 in the tumor microenvironment of patients with non-small cell lung cancer and their relationship with clinical prognosis ZHANG Jia-xiu；DENG Lin-feng；SHI Jian-bang；WU Jian-wei Objective To investigate the expression of tumor-associated macrophages (TAMs)and programmed death receptor-1(PD-1)in the tumor microenvironment of patients with non-small cell lung cancer(NSCLC)and their relationship with the prognosis of patients.Methods A total of 76 patients with NSCLC who were diagnosed for the first time in the Department of Thoracic Surgery of the First People′s Hospital of Jiujiang City from January 2019 to December and were undergoing elective surgery were selected as the research objects.The cancer tissues and adjacent tissues were collected during the operation,and the TAMs phenotype and PD-1 expression level were analyzed by immunohistochemistry,the clinical prognostic factors of the patients were collected,the 1-year survival rate was observed,and the TAMs phenotype and PD-1 expression level distribution characteristics under different clinical prognostic factors were analyzed.COX regression were used to analysis the risk factors of patients′death within 1 year.Results The positive expression of PD-1 and CD206 in NSCLC were higher than those in the adjacent tissues,and the positive expression of CD86 was lower than that of the adjacent tissues,and the differences were statistically significant (P<0.05).The positive expression of PD-1 and CD206 in cancer tissues was positively correlated (P＜0.05).The positive expression level of PD-1 in adenocarcinoma was higher than that of squamous cell carcinoma,and the difference was statistically significant(P<0.05).The expression level of well-differentiated CD86 was higher than that of poorly differentiated and moderately differentiated,and the difference was statistically significant(P<0.05).The expression of well-differentiated and moderately differentiated CD206 were lower than that of low-differentiation differentiation,and the differences were statistically significant(P<0.05).The positive expression level of PD-1 in clinical stage Ⅲ and Ⅱ were higher than that in stage Ⅰ,and the differencs were statistically significant(P<0.05).The positive expression level of CD86 in clinical stage Ⅲ and Ⅱ were lower than that in stage Ⅰ,and the differences were statistically significant(P<0.05).The expression level of CD206 in patients with invasive growth was higher than that in non-invasive growth,and the difference was statistically significant(P<0.05).The 1-year survival rate of 76 NSCLC patients was 76.32%.PD-1(β=0.031,RR=1.031,95%CI=1.007-1.056)and CD206(β=0.066,RR=1.068,95%CI=1.013-1.127)were risk factors for the 1-year survival rate of NSCLC patients(P<0.05).Conclusion The expressions of PD-1,CD86 and CD206 in NSCLC cancer tissues and adjacent tissues are significantly different.The high expression of PD-1 and the high infiltration characteristics of M2 macrophages can significantly increase the mortality of patients within one year. 2021 Vol. 28 (32): 4-8 [Abstract] ( 60 ) HTML (42 KB)  PDF  (0 KB)  ( 7 ) 9 Related genetic analysis for preimplantation genetic testing in carriers of balanced translocations with different genders HE Ping；LI Zhe-tao；WANG Wen-dan；WEI Shuo-feng；YAN Ti-zhen Objective To explored the preimplantation genetic testing (PGT)in carriers of balanced translocations with different genders chromosome group composition situation and the influence of different parental sources on the chromosome formation of offspring.Methods The infertile couples who have undergone peripheral blood chromosome examination in Liuzhou Maternal and Child Health Hospital from January 2017 to June 2021 were selected for karyotype analysis,and balanced translocation carriers were screened out,and assisted reproductive technology was implemented for the balanced translocation carrier couples.Stage embryos use high-throughput sequencing technology for embryo PGT,and analyze and compare the types and composition of blastocyst stage embryo chromosomes of carriers of chromosomal balance translocations of different sexes.Results Through chromosome karyotype analysis,a total of 113 couples with one of them as carriers of balanced chromosomal translocation were screened,fourty-two female carriers and seventyone male carriers.Using high-throughput sequencing to perform preimplantation genetic testing for structural rearrangements(PGT-SR)detection,a total of 738 blastocyst stage embryos and obtained 168 transferable embryos were detected,126 were from male carriers,and 42 were from female carriers.The rate of obtaining transferable embryos,the rate of simple unbalanced embryos,the rate of sporadic abnormal embryos,and the rate of complex abnormal embryos were respectively 27.8%,19.6%,41.6%,and 38.8% of male interbalanced carriers.The rate of obtaining transferable embryos,the rate of simple unbalanced embryos,the rate of sporadic abnormal embryos,and the rate of complex abnormal embryos were respectively 15.5%,25.9%,32.9%,41.2% of female interbalanced carriers.The rate of transferable embryos from different parental sources was compared,with significantly different(27.8% from paternal origin,15.5% from maternal origin,χ2=15.253,P<0.05).There was no significant difference in the rate of unbalanced embryos(19.6% from paternal origin,25.9% from maternal origin,χ2=3.096,P>0.05).The rate of sporadic abnormal embryos from different parental origins was compared,with significantly different(41.6% from paternal origin,32.9% from maternal origin,χ2=4.310,P<0.05).There was no significant difference in the rate of complex abnormal embryos (38.8% from paternal origin,41.2% from maternal origin,χ2=0.320,P>0.05).Conclusion The rate of female reciprocal translocation carriers obtaining transferable embryos and the rate of sporadic abnormal embryos were significantly lower than those of male carriers,and the rates of simple unbalanced embryos and complex abnormal embryos were higher than those of male carriers. 2021 Vol. 28 (32): 9-13转18 [Abstract] ( 63 ) HTML (40 KB)  PDF  (0 KB)  ( 7 ) 14 Clinical effect of Zishen Annian decoction in treatment of perimenopausal syndrome with kidney-yin deficiency CHEN Ling-yan；HU Li-sha Objective To investigate the clinical effect of Zishen Annian Decoction in the treatment of perimenopausal syndrome with kidney-yin deficiency.Methods A total of 60 cases of perimenopausal syndrome with kidney yin deficiency syndrome in Maternal and Child Health Hospital of Jiangxi Province from January to October 2020 were selected as the research objects,they were divided into treatment group and control group according to the random number table method,with 30 cases in each group.The treatment group were given Zishen An′nian Decoction for 28 days,and the control group was not administered.The modified Kupperman index score and kidney-yin deficiency syndrome scores of two groups before enrollment,14 days and 28 days of enrollment were compared,and the curative effect of the treatment group was observed.Results There was no significant difference in the modified Kupperman index score between the two groups(P>0.05).The modified Kupperman index score of the treatment group at 14 and 28 d was lower than that of the control group at the same period,and the difference was statistically significant(P<0.05).There was no significant difference in the score of kidney-yin deficiency syndrome between the two groups (P>0.05).The score of kidney-yin deficiency syndrome in the treatment group was lower than that in the control group at 14 and 28 days,the difference was statistically significant(P<0.05).The total effective rate of the treatment group was 73.33%.Conclusion Zishen Annian Decoction in the treatment of perimenopausal syndrome with kidney-yin deficiency can significantly reduce the improved Kupperman score and kidney-yin deficiency syndrome scorewith good curative effect,and the therapeutic effect is related to the treatment time. 2021 Vol. 28 (32): 14-18 [Abstract] ( 59 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 19 Analysis of high risk subtypes and related protein expression of human papillomavirus in different types of cervical cancer CHEN Chen；WANG Hao-yuan Objective To analyze the distribution and expression characteristics of high risk human papillomavirus(HPV)subtypes in cervical adenocarcinoma and squamous cell carcinoma.Methods A total of 120 patients with cervical cancer complicated with high-risk HPV infection diagnosed in Jiangmen Central Hospital from January 2018 to February 2020 were selected as the research subjects.HPV subtypes were analyzed by hybrid captune (HC2)method,and the expression of HPV E6,E7,P53 and Rb proteins were detected by immunohistochemical method,the expression differences of HPV high-risk subtypes and E6,E7,P53,Rb protein in cervical adenocarcinoma and squamous cell carcinoma were analyzed,and the correlation between HPV high-risk subtypes and E6,E7,P53,Rb protein expression were analyzed.Results Among the 120 cases of cervical cancer,34 cases were adenocarcinoma and 86 cases were squamous cell carcinoma.The proportion of HPV 18 subtype in cervical adenocarcinoma was higher than that in squamous carcinoma,and the proportion of HPV 16 subtype was lower than that in squamous carcinoma,and the multiple infection rate in cervical adenocarcinoma was higher than that in squamous carcinoma,the differences were statistically significant(P<0.05).There was no significant difference in E6 protein expression between cervical adenocarcinoma and squamous cell carcinoma (P>0.05).The expression of E7 protein in cervical adenocarcinoma was higher than that in cervical squamous cell carcinoma,while the expression of P53 and Rb protein was lower than that in cervical squamous cell carcinoma,the differences were statistically significant(P<0.05).HPV 16 subtype,HPV 18 subtype and positive expression of E6,E7,P53 and Rb protein in cervical cancer patients were positively correlated (P<0.05).Conclusion HPV 16 is the main high-risk HPV subtype of cervical squamous cell carcinoma,and HPV 18 is the main highrisk HPV subtype of cervical adenocarcinoma.There are large differences in the positive expression of E7,P53 and Rb protein between cervical squamous cell carcinoma and adenocarcinoma.Cervical adenocarcinoma Higher multiple infection rate and higher co-expression rate of E6 and E7 may be important factors affecting poor prognosis,and it is worthy of further study and discussion. 2021 Vol. 28 (32): 19-22 [Abstract] ( 52 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 23 Meta-analysis of diagnostic value of glycosylated serum albumin in diabetes mellitus LUO Jin-hua；HE Lai-peng；YUAN Man Objective To evaluate the diagnostic value of glycated serum albumin in diabetes mellitus by meta-analysis.Methods Databases including PubMed,Cochrane Library,Wanfang,VIP,CNKI were retrieved by computer,and the literatures about the diagnostic value of glycated serum albumin for diabetes mellitus published before December 30,2020 were screened out.Diagnostic test accuracy quality assessment tool QUADAS-2 was used to evaluate the quality of the included literature,meta-disc 1.4 and Stata 15.1 software lines were used for comprehensive quantitative evaluation.Results A total of 18 articles were included.Meta-analysis showed that the combined sensitivity(SE)of glycated serum albumin in the diagnosis of diabetes mellitus was 0.73,95%CI=0.71-0.74;combined specificity (SP)was 0.89,95%CI=0.88-0.89;combined diagnostic odds ratio(DOR)was 30.52,95%CI=18.31-50.87;area under the SROC curve(AUCSROC)was 0.8366,SEAUC=0.0522.They were divided into three subgroups according to population,race and diagnostic criteria.The combined SE,combined SP,combined DOR,combined positive likelihood ratio(PLR),AUCSROCin hospital group were higher than those in community group,while the combined negative likelihood ratio (NLR)was lower than that in community group.The combined SE,combined SP,combined DOR,combined PLR and AUCSROCof the yellow race group were higher than those of the non-yellow race group,while the combined NLR was lower than that of the non-yellow race group.The combined SP,combined PLR,combined NLR in the oral glucose tolerance test(OGTT)group were higher than those in the non-OGTT group,combined SE,combined DOR and AUCSROCwere lower than non-OGTT group.Conclusion The sensitivity of glycated serum albumin in diagnosing diabetes mellitus is fair,with high specificity and high diagnostic accuracy. 2021 Vol. 28 (32): 23-27 [Abstract] ( 56 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 28 Research progress of hyperlipidemia acute pancreatitis GUO Ling-long；LI Juan-juan；LI Jing-wei；JIANG Xiao-yan；ZHANG Chun-hong；HUANG Bin With the improvement of people′s living standards and changes in dietary patterns,the incidence of hyperlipidemia acute pancreatitis (HLAP)continues to rise.It has the characteristics of younger,more severe,easy to relapse,and atypical symptoms,and there are no relevant guidelines for HLAP to guide the treatment of HLAP,so HLAP is attracting more and more attention.In this paper,we summarize the research on HLAP at home and abroad in terms of etiology,pathogenesis and treatment,and conclude that hyperlipidemia is the key predisposing factor of HLAP,and the pathogenesis is mainly related to free fatty acid damage,microcirculatory disorders,inflammatory response,calcium overload and oxidative stress and so on.However,the lack of a clear treatment plan and the severity of the disease make the treatment difficult.Therefore,the latest research on HLAP in recent years is discussed in order to provide reference for the clinical treatment of HLAP. 2021 Vol. 28 (32): 28-32 [Abstract] ( 44 ) HTML (50 KB)  PDF  (0 KB)  ( 7 ) 33 Research progress of hyperlipidemic acute pancreatitis LAI Meng-chao；WU Xiong-jian Acute pancreatitis is an acute inflammation of the pancreas,the common cause of which is biliary and hyperlipidemia.In recent years,with the change of people′s lifestyle and dietary conditions,the incidence of acute pancreatitis with hyperlipidemia as the etiology is on the rise.The treatment and prognosis of hyperlipidemic acute pancreatitis are often related to serum triglyceride levels.At present,clinical treatment options include:general treatment,drug therapy,blood purification,Chinese herbal adjuvant therapy,etc.While for some special hyperlipidemic acute pancreatitis,such as familial celiac syndrome,there are special gene drug treatment options.Therefore,this article reviews the research progress in the treatment of hyperlipidemic acute pancreatitis,hoping to help clinicians in the treatment of patients with hyperlipidemic acute pancreatitis. 2021 Vol. 28 (32): 33-36 [Abstract] ( 50 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 37 Expression and clinical significance of claudin-1，E-cad，CyclinD1 and nm23 in different differentiated lung adenocarcinoma YANG Bai-lu；LI Zi-yan；ZHANG Yan-wei；XIE Yong；CAO Di；BAI Qing-yang Objective To investigate the expression of Claudin-1,E-Cadherin (E-cad),CyclinD1 and non-metastatic 23 (nm23)in different differentiated lung adenocarcinoma cells,and to explore their correlation with the degree of differentiation and prognosis of lung adenocarcinoma.Methods From March 2013 to March 2017,the lung adenocarcinoma tumor tissue specimens and normal tissue specimens adjacent to the lung adenocarcinoma of 60 patients undergoing lung adenocarcinoma surgery admitted to the Clinic Pathology Diagnosis Center of Qiqihar Medical College were selected as the research objects.The tumor tissue samples were set as the experimental group,and the normal tissue samples adjacent to the lung adenocarcinoma were set as the control group.According to the morphological characteristics of light microscopy,lung adenocarcinoma tumor tissue samples were divided into high differentiation,medium differentiation and low differentiation.Immunohistochemical staining was used to detect the expressions of Claudin-1,E-CAD,CyclinD1 and nm23 in cancer,adjacent and normal tissues.Samples were respectively obtained from cancer,paracancerous and normal lung tissues.Immunohistochemical staining was implemented to detect the expression of Claudin-1,E-cad,nm-23 and CyclinD1.Results The expressions of E-cad and nm23 in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CyclinD1 and Claudin-1 in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).The expression of E-cad and nm23 in highly differentiation was higher than that in low differentiation,and the differences were statistically significant(P<0.05).The expression of CyclinD1 and Claudin-1 in highly differentiation was lower than that in low dif-ferentiation,and the differences were statistically significant(P<0.05).Conclusion Claudin-1,E-cad,nm23 and CyclinD1 play an antagonistic role in the occurrence and development of tumors,which affect the evolution of tumors.They can be used as auxiliary indicators for histological classification,clinical stage and prognosis. 2021 Vol. 28 (32): 37-39转44 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 40 Construction of Dectin-1 gene knockout mouse models based on CRISPRCas9 CHEN Jie；XIE Ye-wen；PAN Jie；DING Jun Objective To investigate the effect of the deletion of the dendritic cell-associated C-type lectin-1(Dectin-1)gene on the tumor growth in mice.Methods CRISPR-Cas9 gene editing technology was used to construct the Dectin-1 gene knockout mouse model.sgRNA targeting the gene of interest was designed to achieve specific cutting of DNA double strand by Cas9 protein.The F0 generation mice were obtained from C57BL/6 surrogate mice,which were fertilized egg micro-injected with sgRNA and ssDNA purified in vitro and Cas9,and Dectin-1 deficient mice were obtained from F0 generation mice by gene identification and DNA sequencing.The tumor models of Wild-type and Dectin-1 knockout mice were further established to evaluate Dectin-1 on the antitumor effect of beta-glucan.Results The Dectin-1 gene of C57BL/6 wild-type mice was successfully knocked out using CRISPR-Cas9 gene editing technology.The deletion of partial nucleotides of Dectin-1 gene was confirmed by PCR technology and DNA sequencing,and the functional experiment showed that the tumor growth rate of Dectin-1 knockout mice was higher than that of wild-type mice,the difference was statistically significant(P<0.05).Conclusion The Dectin-1 gene knockout mouse model is successfully constructed,and the mouse tumor model further confirms the effect of Dectin-1 on the antitumor of beta-glucan,which can lay a foundation for the further study of the role of Dectin-1 in tumor immunotherapy. 2021 Vol. 28 (32): 40-44 [Abstract] ( 43 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 45 Correlation between serum CA125 and ascites in patients with liver cirrhosis ZHANG Xiao；ZHOU Xin-hua Objective To investigate the correlation between serum carbohydrate antigen 125 (CA125)and ascites in patients with liver cirrhosis.Methods A total of 102 patients with liver cirrhosis who treated in People′s Hospital of Pingxiang City from September 2019 to December 2020 were selected as research objects and were divided into the cirrhosis group(36 cases)and the ascites cirrhosis group(66 cases)according to different disease types.Fasting elbow venous blood was collected and serum CA125 level was determined.The differences of CA125 levels in cirrhotic group,ascites cirrhosis group and different Child-Pugh grades were compared.The differences of CA125 levels in ascites cirrhosis group and the correlation between CA125 and Child-Pugh grades and ascites were analyzed by Spearman rank correlation.Results The serum CA125 level of ascites cirrhosis group was(386.81±35.84)U/ml,which was higher than that of cirrhotic group(18.78±3.65)U/ml,and the difference was statistically significant(P<0.05).With the continuous increase of Child-Pugh grades and the amount of peritoneal effusion increased,the serum CA125 level gradually increased,and the differences were statistically significant(P<0.05).CA125 level was positively correlated with Child-Pugh grades and peritoneal fluid volume(r=0.605,0.732,P<0.05).Conclusion Serum CA125 level is closely related to Child-Pugh grades and the amount of ascites,which can be used as an important index to evaluate the degree of liver function damage and the amount of ascites. 2021 Vol. 28 (32): 45-47 [Abstract] ( 52 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 48 The clinical efficacy and safety of ultrasound-guided radiofrequency thermocoagulation of the sensory nerve plexus of the knee in osteoarthritis ZHANG Zhi-gang；WANG Ya-li；GENG Peng-cheng；XIAO Jian-min Objective To investigate the clinical efficacy and safety of ultrasound-guided radiofrequency thermocoagulation of the sensory nerve plexus of the knee in osteoarthritis.Methods A total of 160 patients with osteoarthritis of the knee who were admitted to the Department of Orthopedics of Ningjin County People′s Hospital from March 2020 to November 2020 were selected as the research subjects,and they were divided into two groups A and B using a random number table method,eighty for each group.Group A received pain point anti-inflammatory analgesic solution and sodium hyaluronate injection in the knee joint cavity,group B received ultrasound-guided radiofrequency thermocoagulation of the sensory nerve plexus of the knee joint on the basis of group A.The visual analog scale (VAS)score,the keen society score (KSS)score and the occurrence of complications during the treatment were compared between the two groups.Results Before treatment,there were no significant differences in VAS score and KSS score between the two groups of patients(P>0.05).The VAS score of group B was lower than those of group A at 1 month and 3 months after treatment,and the KSS scores of 1 week,1 month,and 3 months after treatment were all higher than those of group A,the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Ultrasound-guided radiofrequency thermocoagulation of the sensory nerve plexus of the knee joint assisted in the clinical treatment of osteoarthritis is beneficial to relieve pain,improve joint function,and is safe. 2021 Vol. 28 (32): 48-51 [Abstract] ( 55 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 52 Clinical effect of Hydrotalcite combined with quadruple therapy in the treatment of helicobacter pylori infection and duodenal ulcer CHENG Lin；ZHANG Xian-jun Objective To explore the clinical effect of Hydrotalcite combined with quadruple therapy in the treatment of helicobacter pylori(Hp)infection and duodenal ulcer(DU).Methods A total of 108 DU patients with HP infection who were visited in the outpatient department of Qianjiang Central Hospital Affiliated to Changjiang University from May 2017 to December 2019 were selected.According to the random digital table method,they were divided into control group(n=54)and study group(n=54).The control group was given a quadruple regimen of Colloidal Bismuth Tartrate,Pantoprazole,Clarithromycin and Amoxicillin.The study group was combined with Hydrotalcite on this regimen.The clinical efficacy and Hp eradication rate of the two groups of patients after treatment were compared,and the changes in serum inflammatory factor levels before and after treatment were compared.Results The total effective rate of treatment and Hp eradication rate in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,the levels of serum interleukin-6(IL-6)and tumor necrosis factor alpha (TNF-α)in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Hydrotalcite combined with quadruple therapy can improve the clinical symptoms of DU patients with Hp infection,increase the Hp eradication rate,reduce the level of inflammatory mediators,Improve the degree of inflammation of gastric antrum mucosa,and enhance the efficacy. 2021 Vol. 28 (32): 52-54 [Abstract] ( 57 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 55 Clinical diagnostic value of Xpert MTB/RIF technique in patients with non sputum and bacterial negative pulmonary tuberculosis LIN Yi-min；LI Min；CHEN Feng-di Objective To study the detection effect and application value of mycobacterium tuberculosis(MTB)/Rifampin (RIF)resistant real-time fluorescent quantitative nucleic acid amplification (Xpert MTB/RIF)in patients with non sputum and bacterial negative pulmonary tuberculosis.Methods A total of 56 patients with suspected sputum free and bacterial negative pulmonary tuberculosis admitted to Qingyuan People′s Hospital from January 2019 to October 2020 were selected as the research objects.After admission,all patients underwent sputum smear acid fast staining examination,and sputum smear was negative for three times.According to imaging detection,patients with no sputum or less sputum underwent bronchoscopy and alveolar lavage,after collecting the bronchoalveolar lavage fluid,they were divided into 3 parts (5 ml/part)and detected by acid fast bacilli smear,Mycobacterium tuberculosis complex DNA and xpert MTB/RIF at the same time.Results The sensitivity,positive predictive value and negative predictive value of Xpert MTB/RIF technology detection were higher than those of Mycobacterium tuberculosis complex DNA detection and acid-fast smear detection,and the specificity is higher than that of Mycobacterium tuberculosis complex DNA detection,and the differences were statistically significant(P<0.05).Conclusion Xpert MTB/RIF technology plays an important role in the clinical detection and drug sensitivity test of Mycobacterium tuberculosis negative pulmonary tuberculosis patients,which is conducive to the early diagnosis and treatment of patients,and has high clinical application value. 2021 Vol. 28 (32): 55-57 [Abstract] ( 57 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 58 Study on risk factors and prognosis of nosocomial infection in elderly patients with chronic gastritis complicated with upper gastrointestinal bleeding WANG Xiao-qian Objective To study on risk factors and prognosis of nosocomial infection in elderly patients with chronic gastritis complicated with upper gastrointestinal bleeding(UGIB).Methods A total of 358 elderly patients with chronic gastritis admitted to the Department of Gastroenterology,Zhuanghe Central Hospital from October 2018 to January 2020 were selected as the research subjects.Among them,a total of 173 patients with UGIB were included in the study group,and the remaining a total of 185 patients without UGIB were included in the control group.The incidence of infection and prognosis during hospitalization were compared between the two groups of patients,and the logistic regression equation was used to analyze the influencing factors of the patient′s infection.Results The incidence of infection in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in gender,body mass index,hypertension,lung disease,blood transfusion treatment and chronic gastritis between infected and uninfected patients(P>0.05);age of infected people,prevalence of diabetes,invasive hemostasis application the number of cases were higher than those of uninfected patients,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that age≥70 years,long hospital stay,diabetes mellitus and invasive hemostasis were all risk factors for nosocomial infection in elderly patients.According to the bleeding volume of the patients,a total of 60 cases of mild bleeding patients,a total of 75 cases of moderate bleeding patients,and 38 cases of severe bleeding patients were shown.The recurrence rate,fatality rate and infection rate of severe bleeding patients were higher than those of moderate and mild bleeding patients,the differences were statistically significant(P＜0.05).Conclusion The elderly patients with chronic gastritis and UGIB are at higher risk of nosocomial infections.Among them,patients≥70 years of age,longer hospital stay,diabetes and invasive hemostasis are all risk factors for nosocomial infection,and patients with heavier bleeding the higher incidence of infection and the worse the prognosis. 2021 Vol. 28 (32): 58-60转64 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 61 Effect of lower limb positive pressure support treadmill training combined with intramuscular effect in the rehabilitation of musculoskeletal injuries and its influence on the recovery of sports function WANG Wen-zong Objective To observe the effect of applying lower extremity positive pressure to support the treadmill and intramuscular effect patch in the rehabilitation training of musculoskeletal injury and its influence on the recovery of sports function.Methods From January 2018 to January 2021,80 patients with musculoskeletal injury admitted to the Department of Rehabilitation,the First Affiliated Hospital of Fujian Medical University were selected as the research objects,and they were divided into the control group and the intervention group according to a random lottery method,with 40 cases in each group.The control group used lower limb positive pressure support treadmill training,and the intervention group was treated with muscle effect tape based on the control group.The muscle strength of quadriceps femoris,triceps calf tension,balance ability of lower limbs and walking gait were compared between the two groups.Results After treatment,the unarmed muscle strength table(MMT)score of the intervention group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the melioration Ash-worth scale(MAS)score of the intervention group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the Berg balance scale(BBS)score of the intervention group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the timed up and go test(TGUT)of the intervention group was shorter than that of the control group,and the difference was statistically significant significance (P<0.05).After treatment,the step length,step width and pace of the intervention group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion In the rehabilitation training of musculoskeletal injury,the effect of using lower limb positive pressure support treadmill and intramuscular effect patch is significant,which can improve the muscle strength of the posterior quadriceps,the tension of the calf triceps,and the balance ability of the lower limbs.Walking gait promotes the recovery of motor function and is worthy of popularization and application. 2021 Vol. 28 (32): 61-64 [Abstract] ( 62 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 65 Effect of continuous oxygen-driven atomization inhalation on prevention of prolapse pneumonia in elderly bedridden patients CHEN Li-li；DU Chao；CHEN Xiao-an Objective To analyze the effect of continuous oxygen driven aerosol inhalation on prevention of entrapment pneumonia in elderly bedridden patients.Methods From July 2019 to September 2020,90 elderly bedridden patient in Zaozhuang Mental Health Center were selected and divided into control group and observation group according to random odd-even number method,with 45 cases in each group.The control group was treated with ultrasonic atomization inhalation,and the observation group was treated with continuous oxygen driven atomization inhalation.The incidence of entrapment pneumonia,survival rate,blood gas index,quality of life score and satisfaction of patients were compared between the two groups.Results The incidence of entrapment pneumonia in the observation group was lower than that in the control group,the survival rate was higher than that in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in arterial blood gas indexes between the two groups (P>0.05).After treatment,PaCO2in the observation group was lower than that in the control group,SaO2and PaO2in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,PaCO2of the two groups were lower than those before treatment,SaO2 and PaO2were higher than those before treatment,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the scores of quality of life between the two groups (P>0.05).After intervention,the scores of physiological function,vitality,physiological function,general health,physical pain,emotional function,mental health and social function in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).After intervention,the scores of physical function,vi-tality,physical function,general health,physical pain,emotional function,mental health and social function of the two groups were higher than those before intervention,and the differences were statistically significant(P<0.05).The total satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Continuous oxygen driven aerosol inhalation intervention can not only effectively reduce the incidence of entrapment pneumonia,but also improve the survival rate,quality of life and satisfaction of the elderly bedridden patients. 2021 Vol. 28 (32): 65-68 [Abstract] ( 62 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 69 Efficacy and safety of ultrasound-guided percutaneous microwave ablation in the treatment of benign thyroid nodules LI Ji-sheng Objective To analyze and discuss the effect and safety of ultrasound-guided percutaneous microwave ablation in the treatment of benign thyroid nodules.Methods A total of 66 patients with benign thyroid nodules in Anshan Cancer Hospital of Liaoning Province from September 2017 to September 2019 were selected as the research objects,and they were divided into the control group and the observation group according to the dynamic random grouping method,with 33 patients in each group.The control group was treated with conventional surgery,while the observation group was treated with ultrasound-guided percutaneous microwave ablation.The operative indexes,the incidence of complications and thyroid function were compared between the two groups.Results The amount of intraoperative bleeding in the observation group was less than that in the control group,the operation time,postoperative scar length and hospital stay in the observation group were shorter than those in the control group,and the incidence of complications in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).The levels of free triiodothyronine(FT3)and free thyroxine(FT4)in the observation group were higher than those in the control group,and the levels of thyroid stimulating hormone (TSH)in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Ultrasound-guided percutaneous microwave ablation for benign thyroid nodules has significant effect,which can not only improve the operation index,but also reduce the incidence of complications and improve thyroid function,which is suitable for clinical implementation and development. 2021 Vol. 28 (32): 69-71 [Abstract] ( 69 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 72 Comparison of the efficacy and safety of single and bilateral plate internal fixation in the treatment of complex tibial plateau fractures HUANG Qiang Objective To analyze the comparison of the efficacy and safety of single and bilateral plate internal fixation in the treatment of complex tibial plateau fractures.Methods A total of 100 patients with complex tibial plateau fractures admitted to the Department of Orthopedics,People′s Hospital of Yichun City,Jiangxi Province from January 2018 to December 2019 were selected and divided into the control group (50 cases)and the experimental group (50 cases)according to the random number table method.Patients in the control group were treated with unilateral plate internal fixation,and patients in the test group were treated with bilateral plate internal fixation.The treatment effects,total incidence of complications,and various basic indicators after treatment were compared between the two groups.Results The overall effective rate of the experimental group after treatment was higher than that of the control group,and the difference was statistically significant(P＜0.05);the complication rate of the experimental group was lower than that of the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the operation time,length of stay in hospital after operation,blood loss in operation,and fracture healing time between the two groups(P>0.05).Conclusion For the surgical treatment of complex tibial plateau fracture,the choice of bilateral plate internal fixation is more effective,the application advantage of this technique is more obvious. 2021 Vol. 28 (32): 72-74转78 [Abstract] ( 62 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 75 Comparison of clinical effects between minimally invasive percutaneous locking compression plate fixation and traditional fixation in patients with limb fractures YANG Yong-hua；HU Bin；YANG Hai-long；YANG Min-jie；GAO Zhan-wang Objective To investigate comparison of clinical effects between minimally invasive percutaneous locking compression plate fixation and traditional fixation in patients with limb fractures.Methods A total of 82 patients with limb fractures admitted to our hospital from May 2017 to May 2020 were selected as the research subjects.They were divided into an observation group and a control group by a random number table,with 41 cases in each group.Patients in the observation group were treated with minimally invasive percutaneous locking compression plate for internal fixation,while patients in the control group were treated with traditional plate and screw for internal fixation.The clinical efficacy,operation-related indexes,hemorheology indexes,and complications were compared between the two groups.Results The clinical total overall response rate (95.1%)of the observation group was higher than that of the control group accounting for 80.5%,the difference was statistically significant(P<0.05).The surgical time and hospital stay of the observation group were shorter than those of the control group,the intraoperative blood loss of the observation group was less than that of the control group,the incision length of the observation group was shorter than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in whole blood viscosity,plasma fibrinogen or erythrocyte sedimentation rate between the two groups before surgery (P>0.05).The whole blood viscosity,plasma fibrinogen,and erythrocyte sedimentation rate of the observation group were all lower than before surgery,the whole blood viscosity,plasma fibrinogen,and erythrocyte sedimentation rate of the observation group three days after surgery were all lower than those of the control group,the differences were statistically significant(P<0.05).The total complication rate (7.3%)of the observation group was lower than that of the control group accounting for 24.4%,the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of minimally invasive percutaneous locking compression plate in patients with limb fractures is much better than that of traditional plate and screw fixation,and it can effectively improve the local blood circulation of patients to promote the early healing of the fracture of patients,and is conducive to early discharge. 2021 Vol. 28 (32): 75-78 [Abstract] ( 56 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 79 Clinical effect of anterior and posterior surgery combined with Rifampin in the treatment of spinal tuberculosis LI Zhong；LIU Zhi-hong；DAI Zhen-zhen；WANG Chang-fa；WU Ji-guang Objective To explore the clinical efficacy of anterior and posterior surgery combined with Rifampin in the treatment of spinal tuberculosis.Methods The clinical data of 60 patients with spinal tuberculosis treated in the Third People′s Hospital of Jiujiang City from January to December 2019 were retrospectively analyzed.They were divided into the combined group(n=32),the surgery group(n=10)and the single medication group(n=18)according to different treatment methods.The single medication group was treated with Rifampin alone,the surgery group was treated with anterior and posterior surgery,and the combined group was treated with anterior and posterior surgery and Rifampin combined treatment.The clinical efficacy,spinal cord nerve function and Cobb angle were compared among the three groups.Results There were significant difference in the total effective rate of treatment in the combined group,the surgery group and the simple medication group (93.75%,60.00%,66.67%)(P＜0.05).There was no significant difference in the total effective rate between the combined group and the surgery group (P＞0.008).There was no significant difference in the total effective rate between the surgery group and the single medication group(P＞0.008).Postoperative Frankel classification of the combined group were better than those of the surgery group and the simple medication group,and the differences were statistically significant(P＜0.05).The Cobb angle of the combined group([10.85±2.16]°)were lower than those of the surgery group ([13.97±2.64]°)and the simple medication group ([15.12±1.89]°),and the differences were statistically significant(P＜0.05).Conclusion Anterior and posterior surgery combined with Rifampin in the treatment of spinal tuberculosis can correct kyphosis,restore spinal cord nerve function,and promote the healing of tuberculosis lesions,which can be promoted in clinical practice as an optimal treatment for spinal tuberculosis. 2021 Vol. 28 (32): 79-82 [Abstract] ( 51 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 83 Application effect of arthroscopic limited debridement combined with Chinese medicine fumigation in the treatment of early and middle stage knee osteoarthritis CAI Han-hua；CHEN Guo-li；CHEN Jin-hui；YAO Ling；ZHENG Feng Objective To investigate the application effect of arthroscopic limited debridement combined with Chinese medicine fumigation in the treatment of early and middle knee osteoarthritis.Methods A total of 90 patients with early and middle knee osteoarthritis admitted to Affiliated Hospital of Putian University from January 2017 to January 2019 were selected as the research objects.According to the random number table methods,they were randomly divided into the control group and the observation group,45 patients in each group.The control group was treated with arthroscopic limited debridement,and the observation group was treated with arthroscopic limited debridement combined with traditional Chinese medicine fumigation.The score of pain visual analogue scale (VAS),knee range of motion(ROM),Lysholm knee function score before and 2,4,8 and 12 weeks after surgery and the clinical efficacy of traditional Chinese Medicine at 12 weeks after surgery were compared between the two groups.Results The total effective rate of clinical efficacy of traditional Chinese medicine in the observation group at 12 weeks after surgery was 95.56%,which was significantly higher than that in the control group (82.22%),with statistical significance (P＜0.05).Before and 2 weeks after surgery,there were no significant differences in the VAS pain score,knee ROM and Lysholm knee function score between the two groups(P＞0.05).The VAS pain score of the observation group at 4,8 and 12 weeks after surgery were lower than those of the control group,and the differences were statistically significant(P＜0.01).The Knee ROM and Lysholm knee function score of the observation group were higher than those of the control group at 4,8 and 12 weeks after surgery,and the differences were sta-tistically significant(P＜0.01).The VAS pain score,knee ROM and Lysholm knee function score of patients in the same group at 12 weeks after surgery were compared with those before surgery and 2 weeks after surgery,and the differences were statistically significant (P＜0.01).Conclusion Arthroscopic limited debridement combined with fumigation of Bushen Huoxue decoction can effectively relieve the pain of knee joint,improve the function of knee joint,and have a good effect on early and middle knee osteoarthritis. 2021 Vol. 28 (32): 83-87 [Abstract] ( 58 ) HTML (43 KB)  PDF  (0 KB)  ( 7 ) 88 Clinical effect of video-assissted thoracic surgery sleeve lobectomy for central non-small cell lung cancer FAN Hai-yin；ZHANG Jin；YAN Jin-jin；LIU Yu-zhen；ZHAO Long；FU Hong-fan；WANG Wu-ming Objective To explore the clinical effect of video-assissted thoracic surgery sleeve lobectomy for central non-small cell lung cancer(NSCLC).Methods A total of 30 central NSCLC patients in Jiangxi Chest Hospital from Jan 2016 to Dec 2018 were selected as the research objects,then divided into the experimental group (15 cases)and the control group(15 cases)according to the random number table method.The experimental group was treated with videoassissted thoracic surgery sleeve lobectomy,and the control group was treated with traditional open thoracotomy.The related clinical indexes (operation time,intraoperative bleeding,postoperative 6 hours visual analogue scale[VAS]score,postoperative 3 days drainage volume,postoperative drainage time,postoperative hospital stay and the number of lymph node dissection groups]and postoperative complications occurred of two groups were compared.Results The intraoperative blood loss and postoperative 3 days drainage volume of the experimental group were less than the control group,the postoperative 6 hours VAS score were lower than the control group,the postoperative drainage time and postoperative hospital stay of the experimental group were shorter than the control group,the differences were statistically significant(P<0.05);There were no statistically significant of operation time and the number of lymph node dissection groups between the two group (P>0.05).There was no statistically significant in total incidence of postoperative complications between the two group (P>0.05).Conclusion Video-assissted thoracic surgery sleeve lobectomy can significantly reduce the amount of blood loss of central NSCLC patients,shorten the postoperative hospital stay and effectively reduce the degree of postoperative pain,which is safe and feasible. 2021 Vol. 28 (32): 88-91 [Abstract] ( 58 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 92 Correlation analysis of procalcitonin and D-dimer with lung cancer ZHOU Jian-zhong Objective To analyze the correlation between procalcitonin (PCT)and D-dimer and lung cancer.Methods A total of 63 patients with lung cancer admitted to Affiliated Hospital of Jinggangshan University were enrolled as observation group between June and November 2020,while other 36 healthy controls during the same period were enrolled as control group.The levels of PCT and D-dimer in the two groups were compared,and the levels of PCT and D-dimer in patients with different lung cancer stages in the observation group were compared,and the correlation between PCT and D-dimer and the occurrence and development of lung cancer was analyzed.Results PCT and D-dimer levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC of PCT and D-dimer in the diagnosis of lung cancer was 0.855 and 0.920,respectively,lower than that of the combined detection of PCT and D-dimer(0.967)(P<0.05).The serum LEVELS of PCT and D-dimer in observation group increased with the progression of cancer stage (P<0.05).PCT and D-dimer levels were positively correlated with lung cancer stage progression (P<0.05).Conclusion The levels of PCT and D-dimer are related to the occurrence of lung cancer,which can be applied in the early screening and diagnosis of lung cancer.The levels of PCT and D-dimer are also closely related to the progression of lung cancer staging. 2021 Vol. 28 (32): 92-94 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 95 Application of transurethral plasma enucleation of bladder tumor and transurethral resection of bladder tumor in non-muscular invasive bladder cancer ZHANG Shou-peng Objective To compare and analyze the clinical efficacy and 1-year follow-up of transurethral plasma enucleation of bladder tumor(TeURBT)and transurethral resection of bladder tumor(TURBT)in the treatment of non-muscular invasive bladder cancer.Methods A retrospective analysis of 92 patients with non-muscular invasive bladder cancer admitted to the Department of Urology in the Dandong Central Hospital from June 2018 to December 2019 was conducted.They were divided into the group A and the group B according to different surgical methods,with 46 patients in each group.The group A were given TURBT operation and the group B were given TeURBT operation.The perioperative indicators,complications,serum indicators and recurrence were compared and analyzed between the two groups.Results The operation time in the group B was longer than that in the group A,while the duration of catheter indwelling,bladder irrigation and hospitalization in the group B were shorter than those in the group A,and the blood loss during operation in the group B was less than that in the group A,with statistically significant differences(P<0.05).The total incidences of postoperative complications in the group B was lower than that in the group A,with statistically significant difference(P<0.05).The expressions of monocyte chemoattractant protein-1(MCP-1),human cartilage glycoprotein-39 (YKL40)and vascular endothelial growth factor(VEGF)at the time of reexamination were lower than those before surgery,with statistically significant differences(P<0.05).But there were no statistically significant differences of MCP-1,YKL40 and VEGF between the two groups (P>0.05).The cumulative recurrence rate at 1 year after operation in the group B was 6.52%,which was lower than that in the group A as 21.74%,with statistically significant difference (P<0.05).Conclusion Both TeURBT and TURBT can achieve significant effects in the treatment of nonmuscular invasive bladder cancer,but TeURBT has more advantages in improving perioperative indicators,and reducing incidence of complications and recurrence rate. 2021 Vol. 28 (32): 95-98 [Abstract] ( 59 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 99 Effect of mucosal dissection under digestive endoscopy in the treatment of early gastric cancer and its influence on inflammatory factors and recurrence GAO Xian-hai；FU Chen-xue；BAI Yang-ze Objective To explore the effect of mucosal dissection under digestive endoscopy in the treatment of early gastric cancer and its influence on inflammatory factors and recurrence.Methods The clinical data of 40 patients with early gastric cancer who were treated with digestive endoscopic mucosal dissection from March 2014 to September 2019 in Xincheng Hospital of Liaoyang Central Hospital was retrospectively analyzed as the observation group.The clinical data of 43 patients with early gastric cancer who received traditional surgery during the same period were selected as the control group.The perioperative indicators,serum inflammatory factor levels before and after treatment,and the recurrence rate of 1 year follow-up were compared between the two groups.Results The operation time,hospitalization time,gastric emptying time,and gastrointestinal ventilation time of the observation group were shorter than those of the control group,the intraoperative blood loss of the observation group was less than that of the control group,the complication rate of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).There were no significant differences in the levels of interleukin-6(IL-6),interleukin-8(IL-8),interleukin-12(IL-12)and interleukin-1 β (IL-1β)between the two groups before surgery(P>0.05).The levels of IL-6,IL-8,IL-12 and IL-1β in the two groups were higher than before operation,and the levels of IL-6,IL-8,IL-12 and IL-1β in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the recurrence rate between the two groups(P>0.05).Conclusion Digestive endoscopic mucosal dissection in the treatment of early gastric cancer has better perioperative indexes,lower incidence of related complications,higher safety,and less postoperative recurrence. 2021 Vol. 28 (32): 99-101转112 [Abstract] ( 55 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 102 Analysis of singleton pregnancy outcome and incidence of low birth weight by assisted reproductive technology LI Tian-feng；SHUAI Zhen-hong；ZHANG Wan-jing；LI Xue-mei Objective To investigate the risk factors of singleton pregnancy outcome and incidence of low birth weight(LBW)with assisted reproductive technology(ART).Methods Retrospectively analyzed the clinical data of 1434 patients with live singletons in Shenzhen maternal and child health management system from January 2016 to December 2019.According to the way of pregnancy,they were divided into ART group (691 cases)and natural pregnancy (NC)group(743 cases).The univariate analysis was used to analyze the pregnancy outcome of singleton pregnant women,multivariate logistic regression analysis was performed to explore the risk factors affecting the occurrence of LBW infants.Results The proportion of pregnant women in ART group with bachelor degree or above and no previous pregnancy and childbirth history were higher than those in NC group,and the offspring′s LBW and preterm birth rate of ART group were higher than those in NC group,the differences were statistically significant(P<0.05).Univariate analysis showed that preterm birth was associated with ART offspring′s LBW(P<0.01),however,multivariate logistic regression analysis revealed that preterm birth wasn′t the influence factor of ART offspring′s LBW (OR=0.816,95%CI:0.321-2.073,P=0.670).Conclusion The incidence of ART singleton LBW increased was not related to the related factors involved in this study.However,it is not only necessary to strengthen the management of ART pregnant women with high risk and pay attention to their healthcare during pregnancy and childbirth,but also need to conduct a multi-area,large-sample randomized controlled study to clarify the impact of the occurrence of LBW in ART singletons. 2021 Vol. 28 (32): 102-105 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 106 Guiding effect of bispectral index monitoring on postoperative sedation treatment in patients with severe preeclampsia ZHAO Fei；LIAO Zong-gao；GONG Mei Objective To explore the guiding effect of bispectral index(BIS)monitoring on postoperative sedation treatment in patients with severe preeclampsia.Methods A total of 50 patients with severe preeclampsia treated in Maternal and Child Health Hospital of Jiangxi Province from October 2019 to December 2020 were selected as the research objects.They were divided into control group and observation group according to the random number table method,with 25 cases in each group.Both groups underwent cesarean section surgery.Nitroglycerin and Diazepam injection were used as antihypertensive sedatives.The control group took empirical medications,and the observation group took BIS to monitor the dosage of the drugs,both groups were observed for 48 hours after operation.The mean arterial pressure(MAP)and heart rate (HR)levels before operation,8,24 and 48 hours after operation,and the incidence of eclampsia,postpartum hemorrhage and heart failure at 48 hours after operation of the two groups were compared.Results There were no statistically significant differences in MAP and HR levels between the two groups before surgery(P>0.05).The MAP and HR levels of the two groups at 8,24,and 48 h after surgery were lower than those before surgery,and the MAP and HR levels at 24 h after surgery were lower than those at 8 h after surgery,and the MAP and HR levels at 48 h after surgery were lower than those at 24 h after surgery,the differences were statistically significant(P<0.05).The MAP and HR levels of the observation group at 8,24 and 48 h after surgery were lower than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the observation group at 48 h after surgery was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion BIS monitoring can regulate the dosage of relevant drugs,so as to reduce the levels of MAP and HR in patients with severe preeclampsia,reducing the incidence of postoperative complications,and guiding the drugs to achieve sedative effect. 2021 Vol. 28 (32): 106-108转122 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 109 Effect of lateral episiotomy on postpartum pelvic floor function of vaginal delivery WANG Ying；WEN Ying；MA Lin；LI Hai-ying Objective To explore the effect of lateral episiotomy on postpartum pelvic floor function of vaginal delivery.Methods The clinical data of 86 full-term pregnant women who underwent vaginal delivery in Chunliu District of Dalian Women and Children Medical Center(Group)from February 2019 to February 2021 were retrospectively analyzed.According to the midwifery technology,they were divided into lateral episiotomy group and non lateral episiotomy group,43 cases in each group.The patients in the lateral episiotomy group underwent lateral episiotomy during vaginal natural delivery,and the patients in the non lateral episiotomy group did not undergo lateral episiotomy during vaginal natural delivery.The stress urinary incontinence(SUI),perineal pain,pelvic floor muscle electromyography,pelvic organ prolapse(POP),POP stage and pelvic floor muscle strength were compared between the two groups.Results The incidence of SUI at 42 d after delivery in the lateral episiotomy group was higher than that in the non lateral episiotomy group,the visual analogue scale (VAS)score at 42 d after delivery was higher than that in the non lateral episiotomy group,and the pelvic floor muscle electromyography at 42 d after delivery was lower than that in the non lateral episiotomy group,the differences were statistically significant(P<0.05).There were no significant differences between the two groups in the incidence of POP,POP stage,shallow class Ⅰ and class Ⅱ muscle fiber strength,deep class Ⅰ and class Ⅱ muscle fiber strength at 42 d after delivery (P>0.05).Conclusion The use of lateral episiotomy in vaginal delivery can increase the incidence of SUI and perineal pain,and aggravate the damage to pelvic floor muscle function.Therefore,it is necessary to limit the use of lateral episiotomy and strictly grasp the indications of lateral episiotomy. 2021 Vol. 28 (32): 109-112 [Abstract] ( 38 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 113 Effect of Nifuratel and Three Vitamins and Nysfungin Suppositories on vaginal microflora disorder in pregnant women with mycotic vaginitis LIU Mei-rong；CHI Zhi-qun；ZHANG Yan Objective To investigate the Effect of Nifuratel and Three Vitamins and Nysfungin Suppositories on vaginal microflora disorder in pregnant women with mycotic vaginitis.Methods Sixty patients with mycotic vaginitis during pregnancy admitted to the Department of Obstetrics and Gynecology,Maternal and Child Health Hospital of Ruijin city from January 2019 to December 2020 were retrospectively selected as the research subjects,and were divided into observation group(30 cases)and control group(30 cases)according to treatment methods.The control group was treated with Nifurtel Nystatin Vaginal Ointment,and the observation group was treated with Nifurtel Nystatin Vaginal Ointment combined with Three Vitamins and Nysfungin Suppositories.The clinical treatment effect,vaginal pH value,total incidence of adverse reactions,recurrence rate,colony≥1/2 area rate and correction rate of vaginal flora were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The vaginal pH value of the observation group was lower than that of the control group,the disease recurrence rate of the observation group was lower than that of the control group,and the bacterial colony≥1/2 area rate and vaginal microflora correction rate of the observation group were higher than that of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse drug reaction in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion in the treatment of mycotic vaginitis of pregnancy,the combination of Nifuratel and Three Vitamins and Nysfungin Suppositories can significantly improve the treatment effect,improve the vaginal environment,increase the area rate of beneficial flora in vagina,increase the correction rate of flora in vagina,improve the disorder of vaginal flora,and control the recurrence rate and adverse reactions,which is worthy of promotion. 2021 Vol. 28 (32): 113-115 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 116 Effect of noninvasive positive pressure ventilation in the treatment of severe bronchial asthma in children JIANG Ling；LIAO Long-yue；AI Zhong-hua Objective To investigate the effect of noninvasive positive pressure ventilation (NIPPV)in the treatment of severe bronchial asthma in children.Methods A total of 83 children with severe bronchial asthma treated in the Department of Pediatrics of Xinyu People′s Hospital from January 2017 to September 2020 were selected as research objects and divided into the control group(41 cases)and the treatment group(42 cases)according to the random number table method.The control group received conventional treatment,and the treatment group was given noninvasive positive pressure ventilation on this basis.The children in both groups were observed for 24 h.The clinical efficacy and arterial blood gas changes at different time period before and after treatment were compared between the two groups.Results The total clinical effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no significant differences in the levels of partial pressure of oxygen(PO2),partial pressure of carbon dioxide (PCO2)and blood oxygen saturation (SaO2)between the two groups before treatment(P>0.05).At 4,8 and 24 h after treatment,the levels of PO2and SaO2in the two groups were higher than those before treatment,and the levels of PO2and SaO2in the treatment group were higher than those in the control group,the levels of PCO2in the two groups were lower than those before treatment,and the level of PCO2in the treatment group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion NIPPV can effectively improve the clinical symptoms of children with severe bronchial asthma,improve their respiratory function,reduce the diseases′damage to the children′s body,and have a positive impact on the children′s recovery. 2021 Vol. 28 (32): 116-118 [Abstract] ( 67 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 119 Application effect of early language training in the rehabilitation of children with developmental delay CHEN Li-ping Objective To explore the application effect of early language training in the rehabilitation of children with developmental delay.Methods A total of 76 children with developmental delay admitted to the Department of Rehabilitation in the Quanzhou Women′s and Children′s Hospital from January 2019 to January 2020 were selected.They were divided into the control group and the observation group according to the random number table method,with 38 children in each group.The control group were given conventional rehabilitation training,and the observation group were given additional early language rehabilitation training.The treatment effect and Gesell Developmental Scale score were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in Gesell Developmental Scale score between the two groups before training (P>0.05).The scores of all dimensions of Gesell Development Scale after training were higher than those before training,the scores of all dimensions in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion Early language rehabilitation training can significantly improve training effect and effectively promote children′s language development function in children with developmental delay.It has positive significance for improving children′s language expression and language comprehension ability,indicating values for clinical use and promotion. 2021 Vol. 28 (32): 119-122 [Abstract] ( 54 ) HTML (33 KB)  PDF  (0 KB)  ( 5 ) 123 Effect of Magnesium Sulfate combined with Ritodrine Hydrochloride on premature rupture of membranes SHEN Xia；GENG Mao-lin；DONG Juan-li Objective To analyze the therapeutic effect of magnesium sulfate combined with ritodrine hydrochloride on premature rupture of membranes.Methods A total of 86 patients with premature premature rupture of membranes admitted to Korla Hospital of the Second Division of Xinjiang Production and Construction Corps from March 2020 to March 2021 were selected.They were divided into study group and control group according to the different treatment schemes,with 43 cases in each group.Those who were given Magnesium Sulfate treatment were recorded as the control group,those who were treated with Magnesium Sulfate combined with Ritodrine Hydrochloride were recorded as the study group.And the comprehensive effective rate of treatment,uterine contraction inhibition time,pregnancy extension time,neonatal Apgar score,pregnancy outcome,cytokine level,the total incidence of adverse reactions of the two groups were compared.Results The comprehensive effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).The inhibition time of uterine contraction in the study group was shorter than that in the control group,the extension time of pregnancy was longer than that in the control group,and the neonatal Apgar score and vaginal delivery rate were higher than those in the control group,the differences were statistically significant(P<0.05).The study group′s interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),fetus fibronectin(fFN)and prostaglandin E2(PGE2)was lower than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion During the clinical treatment of patients with premature rupture of membranes,the use of Magnesium Sulfate combined with Ritodrine Hydrochloride can achieve satisfactory therapeutic effect,can significantly prolong the gestational age,increase the newborn′s Apgar score,vaginal delivery rate,and better improve IL-6,TNF-α,fFN,PGE2and other cytokine levels,and the combination of drugs will not greatly increase the adverse drug reactions,and the safety is reliable. 2021 Vol. 28 (32): 123-125转129 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 126 Application effect of gonadotropin-releasing hormone agonists combined with laparoscopic surgery in the treatment of ovarian endometriosis cyst SUN Bo；LIU Lian-hua Objective To investigate the efficacy of gonadotropin-releasing hormone agonist(GnRH-a)combined with laparoscopic surgery in the treatment of ovarian endometriosis cyst.Methods A total of 60 patients with ovarian endometriosis cyst admitted to Nanjing Jiangning Hospital from September 2018 to September 2020 were retrospectively selected as the study subjects,and were divided into experimental group (32 cases)and control group (28 cases)according to different treatment regimens.The control group was treated directly with laparoscopic surgery,and the experimental group was treated with GnRH-a on the basis of the control group.The levels of luteinizing hormone(LH),estradiol(E2),follicle stimulating hormone (FSH),menstrual cycle,menstrual time and dysmenorrhea were compared before and after the two groups.The recurrence rate and pregnancy status were followed up for half a year.Results After treatment,the LH and E2levels in the two groups were lower than before,and the LH and E2levels in the experimental group were lower than those in the control group,with statistical significance(P<0.05).There was no significant difference in FSH level between 2 groups before and after treatment(P>0.05).After treatment,the menstrual cycle of the two groups was shorter than before treatment,and the menstrual duration was longer than before treatment,with statistical significance (P<0.05).There was no significant difference in menstrual cycle and menstrual time between the two groups after treatment(P>0.05).Follow-up for half a year,the recurrence rate of the experimental group was lower than the control group,the postoperative pregnancy rate of the experimental group was higher than the control group,the difference was statistically significant(P<0.05).Visual analogue scale (VAS)score of dysmenorrhea in the two groups after treatment was lower than before,and VAS score of dysmenorrhea in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion GnRH-a combined with laparoscopic surgery in the treatment of patients with ovarian endometriosis cysts obtains a good application effect.It can restore the patient′s hormone level,promote the recovery of the patient′s menstrual condition,and alleviate the patient′s dysmenorrhea. 2021 Vol. 28 (32): 126-129 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 130 Analysis of dental unit waterlines infection ZHAI Yan；BAO Ai-qin；JIANG Fan；LI Yan-hui Objective To explore and analyze the influencing factors of dental unit waterlines(DUWLS).Methods A total of 76 dental chair units (DCU)in 6 general hospitals in Futian District of Shenzhen from June 2018 to December 2019 were selected as the subjects.According to China′s drinking water testing standards,on-site evaluation and hygienic sampling methods were used to determine whether the DUWLS of oral comprehensive treatment units were infected,and they were divided into infected group(n=23)and uninfected group(n=53)according to the water sample test results.The general data of the two groups of DUWLS were recorded,including:installation time,average daily service person times,regular maintenance,cleaning and disinfection after use,water supply source,whether the mobile phone/three-purpose water gun were sucked back,and the influencing factors were analyzed.Results A total of 228 water samples were collected,of which 70 were positive,with an infection rate of 30.70%,and the highest positive rate of effluent from mobile phones was 48.68%.The results of univariate analysis indicated that there were statistically significant differences between the two groups in average daily service visits,regular maintenance,cleaning and disinfection after use,water supply sources,and whether the mobile phone/three-use gun was sucked back (P<0.05).The results of multivariate analysis showed that the average daily service time exceeded 10 people (β=0.692,OR=2.684,95%CI=1.860-3.696),no regular maintenance (β=0.427,OR=2.092,95%CI=1.714-3.172),no cleaning and disinfection after use 95%CI=3.341-8.391),using municipal water source (β=0.246,OR=1.592,95%CI=1.249-2.367),mobile phone/three-purpose gun suck back (β=1.891,OR=6.143,95%CI=4.121-10.461)were the risk factors of DUWLS infection.Conclusion DUWLS infection rate is high,and it is affected by many factors.It is necessary to formulate corresponding intervention measures according to possible influencing factors to reduce the hospital infection rate. 2021 Vol. 28 (32): 130-133 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 134 Analysis on the accuracy of 6 formulas for calculating the degree of intraocularlens in cataract patients with an eye with a long axial length YANG Zhi；SHI Qing-cheng；WU Hai-juan；ZHOU Yan-wen Objective To compare the accuracy of postoperative refractive calculation with the six intraocularlens(IOL)calculation formulas(Kane,Hoffer QST,Barrett Universal Ⅱ,SRK-T,Hoffer Q and Holladay2)in long-axis cataract patients.Methods Retrospective case-series study.The clinical data of 44 cases(44 eyes)of long-axis cataract(＞26 mm)from March 2019 to March 2020 collected at Shenyang aier optometric hospital were analyzed.All patients underwent phacoemulsification combined with implantation of intraocular lens.The median absolute refraction errors(Med AE)and the proportion of the error within 0.50 D and 1.0 D of the six formulas were calculated and compared.Results Barrett Universal Ⅱ,Kane formula compared with SRK-T,Hoffer Q and Holladay 2 formula,Hoffer QST formula compared with Hoffer Q and Holladay2 formula,the error was smaller,and the differences were statistically significant(P<0.05).The proportions of the errors within 0.5 D of Kane,Barrett Universal Ⅱ,Hoffer QST,SRK-T,Holladay2 and Hoffer Q formulas were 36.4%,27.3%,22.7%,9.1%,4.5%,4.5%,respectively,the differences were statistically significant(P<0.001).The proportions within 1.0 were 70.5%,63.6%,50%,31.8%、11.4%,9.1%,respectively,the differences were statistically significant(P<0.05).The mean refractive error(ME)of Kane,Barrett Universal Ⅱ,Hoffer QST,SRK-T,Holladay2 and Hoffer Q formulas were 0.64±0.61,0.82±0.55,1.01±0.64,1.32±0.64,1.64±0.62,1.91±0.61,with statistically significant differences.Conclusion Among the six formulas,Kane,Barrett Universal Ⅱ and Hoffer QST are more accurate in the calculation of IOL degree for patients with long-axis cataract,the proportions within 0.5 D and 1.0 D are higher,are recommended for clinical use.All formulas drift towards farsightedness,so it is suggested to reserve a certain degree of myopia according to the axial length. 2021 Vol. 28 (32): 134-136 [Abstract] ( 58 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 137 Clinical comparative analysis of immediate implant restoration and residual root preservation restoration in the treatment of patients with dental defects SHI Fu-qiao；ZENG Xian-huan；ZHANG Xin-lu；CHEN Bei-si；YUN Hui-yuan Objective To explore and compare the clinical effects of immediate implant restoration and residual root preservation restoration in the treatment of patients with dental defects.Methods A total of 100 patients with dental defects treated in the Department of Stomatology,Airport Hospital of Tianjin Medical University General Hospital from January 2019 to June 2020 were selected as the research objects.They were divided into control group and experimental group according to the computer grouping method,with 50 cases in each group.The control group was treated with residual root preservation repair,and the experimental group with immediate implant repair.The cure,oral function score,clinical efficacy,complications and satisfaction of the two groups were compared.Results The oral function score of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).The incidence of complications in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).The satisfaction of experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion The comparison of immediate implant restoration and residual root preservation and restoration shows that implant restoration has better clinical effects,which can effectively improve the oral function of patients with tooth defects,immediate improve the cure rate and patient satisfaction,and have a low incidence of complications. 2021 Vol. 28 (32): 137-139转143 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 140 Clinical effect of Qiming Granule combined with Esculin and Digitalis Glycosides Eye Drops in the treatment of type 2 diabetes mellitus dry eye LI Chun-wei；CHANG Dan Objective To investigate the clinical effect of Qiming Granule combined with Esculin and Digitalis Glycosides Eye Drops in the treatment of type 2 diabetes mellitus(T2DM)complicated with dry eye.Methods From September 2018 to September 2020,a total of 120 patients with dry eye complicated with T2DM admitted to the Department of Ophthalmology,Central Hospital Affiliated to Shenyang Medical College were selected as the research objects,and divided into the experimental group(60 cases)and the control group(60 cases)by systematic randomization.The control group was treated with Qiming Granule orally,while the experimental group was treated with Qiming Granule oral administration combined with Esculin and Digitalis Glycosides Eye Drops.The total effective rate after treatment was compared between the two groups,and the results of breaking up time(BUT),Sehirmer I test(S1t)and fuorescentstaining(FL)before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences in BUT,S1t and FL between the two groups before treatment(P＞0.05).After treatment,BUT,S1t and FL of the two groups were higher than those before treatment in the group,the differences were statistically significant(P<0.05).After treatment,BUT,S1t and FL of the test group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Qiming Granule combined with Esculin and Digitalis Glycosides Eye Drops can significantly improve dry eye symptoms in T2DM dry eye,and it is safe and effective. 2021 Vol. 28 (32): 140-143 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 144 Effect comparison of the zirconia post and fiber post in restoring the residual root and crown of upper anterior teeth WANG Zhao-hui Objective To investigate the effect of zirconia post and fiber post in restoring the residual root and crown of upper anterior teeth.Methods A total of 61 patients with residual roots and crowns of upper anterior teeth who were admitted to the Third Affiliated Hospital of Xuzhou Medical University from February 2018 to December 2019 were selected as the research subjects.A total of 84 teeth were selected and divided into group A (30 cases,44 teeth)and group B(31 cases,40 teeth)according to the random number table method.Group A was repaired with fiber posts,and group B was repaired with zirconia posts.After the post-core crown restoration,the dentin shoulder collar and tooth body were prepared,and finally the porcelain crown was repaired and cemented.Both groups were followed up for 1 year.The success rate of restoration of residual roots,failure of restoration and chewing efficiency 1 year after restoration were compared in the two groups.Results There was no significant difference in the restoration success rate of group B(90.00%)and group A(77.27%)(P>0.05).In group B,the incidence of post-core loss or fracture,gingival inflammation,staining of the gingival margin,and root fracture was not statistically different from that of group A (P>0.05).The total effectiveness rate of chewing efficiency was compared between group B and group A one year after restoration of the tooth,and the difference was not statistically significant(P>0.05).Conclusion Both the zirconia post and the fiber post can achieve good therapeutic effects in the restoration of the residual root and crown of the upper anterior teeth,and there is no significant difference in the success rate or the effect on the patient′s chewing efficiency.Clinically,the appropriate one can be selected according to the patient′s specific situation. 2021 Vol. 28 (32): 144-146 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 147 Application of Ropivacaine combined with Dexmedetomidine erector spinal block in thoracic spine surgery LIU Zhen-hua；ZHU Jin-you；LI Jun-jun；LONG Yan；YANG Hong-biao；ZHOU Wen Objective To study the clinical effect of Ropivacaine combined with Dexmedetomidine erector spinal block in thoracic spine surgery.Methods A total of 60 patients who planned to receive thoracic surgery in Ganzhou People′s Hospital from June 2019 to November 2020 were selected as the research objects.They were divided into experimental group and control group by random number table method,with 30 patients in each group.The control group was given Ropivacaine erector plane block during thoracic surgery,and the experimental group was given Ropivacaine combined with Dexmedetomidine erector plane block.The operation center rate,mean arterial pressure,dosage of general anesthetics,recovery time of post-anesthesia recovery room(PACU)and complications in recovery period were compared between the two groups.The visual analogue scale (VAS)score at 2,4,8 and 12 h after operation,the number of intravenous analgesic compressions and the satisfaction of patients were compared.Results The operation center rate and mean arterial pressure in the experimental group were lower than those in the control group,the dosage of general anesthesia was lower than that in the control group,and the time of PACU recovery was shorter than that in the control group,the differences were statistically significant(P<0.05).VAS scores of both groups at 4,8 and 12 h after operation were higher than those of this group at 2 h after block,and VAS scores of the experimental group at different time points were lower than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Ultrasonicguided ropivacaine combined with dexmedetomidine erector spinal muscle plane block can be used for thoracic spine surgery analgesia.Dexmedetomidine can significantly prolong the action time of ropivacaine,provide a more complete analgesic effect,and is conducive to the rapid postoperative recovery of patients undergoing thoracic surgery. 2021 Vol. 28 (32): 147-149 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 150 Influence of superficial cervical plexus block on the quality of resuscitation and inflammatory response in patients undergoing general anesthesia for thyroid surgery WU Hong-hui；ZHENG Man；TIAN Wei-qian；JIANG Hui-li；CUI Yao-mei；YANG Guang Objective To investigate the influence of superficial cervical plexus block(SCPB)on the resuscitation quality and inflammatory response of patients undergoing thyroid surgery under general anesthesia.Methods A total of 201 patients requiring thyroid surgery in Affiliated Hospital of Nanjing University of Chinese Medicine from March to November 2020 were retrospectively selected as the study subjects.According to whether bilateral ultrasound-guided SCPB was performed,the patients were divided into SCPB group (82 cases)and non-SCPB group (119 cases).Operation time,intraoperative blood loss,serum interleukin-6(IL-6),tumor necrosis factor-α (TNF-α)and interleukin-1 β(IL-1β)levels,intraoperative dosage of propofol,sufentanil and remifentanil,recovery time of spontaneous breathing of patients in anesthesia recovery room (PACU),time of tracheal tube removal and PACU retention time,visual analogue scale(VAS)score and condition of post operative nausea and vomitting(PONV)at 24 h postoperatively were compared between the two groups.Results There were no significant differences in operative time and intraoperative blood loss between the two groups(P>0.05).The intraoperative dosage of propofol,sufentanil and remifentanil in SCPB group was lower than that in non-SCPB group,the difference was statistically significant(P<0.05).The recovery time of spontaneous breathing and the time of tracheal tube removal were earlier in SCPB group than in non-SCPB group,and the PACU residence time was shorter in SCPB group than in non-SCPB group,the differences were statistically significant(P<0.05).The levels of IL-1β,IL-6 and TNF-α in SCPB group were lower than those in non-SCPB group,the differences were statistically significant(P<0.05).24 h after surgery,VAS score and PONV incidence in SCPB group were lower than those in non-SCPB group,the differences were statistically significant(P<0.05).Conclusions Ultrasound-guided bilateral superficial cervical plexus block could improve the quality of resuscitation in patients undergoing general anesthesia for thyroid surgery.The consumptions of intraoperative anesthetics were reduced,the postoperative pain and PONV during the firsr postoperative 24 h were reduced,and postoperative inflammatory reactions were reduced. 2021 Vol. 28 (32): 150-153 [Abstract] ( 43 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 154 Effect of ultrasound-guided thoracic paravertebral nerve block combined with laryngeal mask general anesthesia on analgesic effect cognitive function and sleep quality in middle-aged and elderly patients with breast cancer ZHANG Feng Objective To investigate the effects of ultrasound-guided thoracic paravertebral nerve block combined with laryngeal mask general anesthesia on analgesic effect,cognitive function and sleep quality in middle-aged and elderly patients with breast cancer.Methods A total of 66 middle-aged and elderly breast cancer patients admitted to Affiliated Hospital of Xuzhou Medical University from January 2018 to January 2021 were selected as the research subjects,and were divided into observation group (33 cases)and control group (33 cases)according to random number table method.Patients in the control group were received general anesthesia with laryngeal mask,and patients in the observation group were received ultrasonic-guided thoracic paravertebral nerve block combined with laryngeal mask general anesthesia.The analgesic effect,cognitive function and sleep quality of the two groups were compared.Results The visual analog scale(VAS)score of the observation group were lower than those of the control group at 4,12 and 24 h after surgery,and the differences were statistically significant(P<0.05).The Mini-Mental State Examination(MMSE)score of the two groups at 1 and 3 h after operation were lower than that before operation,but the MMSE score of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).The score of Pittsburgh Sleep Quality Index(PSQI)in the two groups after surgery were lower than those before surgery,and the PSQI score in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Ultrasound-guided thoracic paravertebral nerve block combined with laryngeal mask general anesthesia can relieve postoperative pain,improve the level of cognitive and improve sleep quality in middleaged and elderly patients with breast cancer. 2021 Vol. 28 (32): 154-157 [Abstract] ( 55 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 158 Clinical effect of Bugan Yishen Huoxue Decoction on liver and kidney deficiency syndrome of ankylosing spondylitis KE Ming-zhu；FENG Xiao-yan；ZHANG Huan-huan；CHEN Chun-wei Objective To explore the clinical effect of Bugan Yishen Huoxue Decoction in the treatment of liver and kidney deficiency syndrome of ankylosing spondylitis.Methods Sixty patients with liver and kidney deficiency syndrome of ankylosing spondylitis who admitted to Yangjiang Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected as the research objects and divided into Western medicine group and Chinese medicine group by coin flipping method,with 30 cases in each group.The Western medicine group was treated with Celecoxib (0.2 g/time,2 times/d),and the Chinese medicine group was treated with Celecoxib and Bugan Yishen Huoxue Decoction(Chinese medicine bulk granules).The curative effect,traditional Chinese medicine(TCM)syndrome score,pain score,spinal joint function,activity index before and after treatment and adverse reactions of the two groups were compared.Results The total effective rate of the Chinese medicine group was higher than that in the Western medicine group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in TCM syndrome score and visual analog scale (VAS)score between the two groups(P>0.05).After treatment,the TCM syndrome score and VAS score of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the TCM syndrome score and VAS score in the Chinese medicine group were lower than those in the Western medicine group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in Bath ankylosing spondylitis functional index(BASFI)and Bath ankylosing spondylitis disease activity index(BASDAI)between the two groups(P>0.05).After treatment,BASFI and BASDAI in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,BASFI and BASDAI in Chinese medicine group were lower than those in Western medicine group,and the differences were statistically significant(P<0.05).There were no serious adverse reactions in the two groups.Conclusion Bugan Yishen Huoxue Decoction is effective in treating liver and kidney deficiency syndrome of ankylosing spondylitis.Comparing with Western medicine alone,it can significantly improving the clinical symptoms and signs of patients,reducing pain,improving spinal joints and mobility,and has high safety. 2021 Vol. 28 (32): 158-161 [Abstract] ( 56 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 162 Effect of microneedle acupuncture on improving swallowing dysfunction in patients with pseudobulbar palsy after stroke YU Hong-mei；WU Gang；LE Zhi-qing Objective To analyze the effect of microneedle acupuncture on improving swallowing dysfunction in patients with pseudobulbar palsy after stroke.Methods A total of 60 patients with pseudobulbar palsy after stroke treated in Jingdezhen Hospital of Traditional Chinese Medicine from September 2018 to October 2020 were selected as the research subjects.They were divided into control group and experimental group by random number table method,with 30 cases in each group.Patients in control group were treated with basic treatment,and patients in experimental group were treated with basic treatment combined with microneedle acupuncture.The clinical efficacy and swallowing function of the two groups were compared.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in modified Mann assessment swallowing ability(MMASA)score between the two groups(P>0.05).After treatment,MMASA scores of the two groups were higher than those before treatment,and the differences were statistically significant(P<0.05).After treatment,MMASA score of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of patients with pseudobulbar palsy after stroke,the effect of microneedle acupuncture is outstanding,which can significantly improve the swallowing dysfunction of patients,and is worthy of clinical promotion. 2021 Vol. 28 (32): 162-164 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 165 Clinical effect of traditional Chinese massage combined with Huoxue Zhitong Decoction for the treatment of limb swelling at the late stage of bone injury ZHANG Yuan；CHEN Zu-ping Objective To explore the therapeutic effect of traditional Chinese massage combined with Huoxue Zhitong Decoction for the treatment of limb swelling at the later stage of bone injury.Methods Ninety patients with post-injury limb swelling who were admitted to the Department of Orthopedics and Traumatology of Ningde Hospital of Traditional Chinese Medicine from February 2019 to February 2020 were selected as the research subjects.They were divided into the control group and the observation group by the random number table method.In the control group,patients were treated with conventional Western medicine,and in the observation group,patients were treated with traditional Chinese massage combined with Huoxue Zhitong Decoction.The therapeutic effect of the two groups were compared.Visual analogue scale (VAS)and swelling degree of pain before and 2 weeks after treatment were compared between the two groups.The recovery of limb function before and after treatment was compared between the two groups.The detumescence time,hospital stay and callus growth time were compared between the two groups.Results The total effective rate of observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).VAS score and swelling degree in observation group at 2 weeks after treatment were lower than those in control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in limb function scores between the two groups(P>0.05).The limb function scores of observation group at 2 weeks after treatment and 3 months after treatment were higher than those of control group,with statistical significances (P<0.05).The detumescence time,hospitalization time and callus growth time in observation group were shorter than those in control group,and the differences were statistically significant(P<0.05).Conclusion Traditional Chinese massage combined with Huoxue Zhitong Decoction is effective in treating limb swelling at the later stage of bone injury.It can effectively alleviate pain,relieve limb swelling,promote callus growth and limb function recovery,speed up swelling disappearance and fracture healing,and shorten hospital stay. 2021 Vol. 28 (32): 165-168 [Abstract] ( 40 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 169 Clinical diagnosis and prognosis analysis of Hcy,PCT and coagulation function in patients with cerebral infarction XU Zhi-jian；FU Dong-qin；LONG Lin-juan Objective To investigate the effect of combined detection of serum homocysteine(Hcy),serum procalcitonin(PCT)and coagulation function on clinical diagnosis and prognosis of patients with cerebral infarction.Methods A total of 80 patients with cerebral infarction admitted to First People′s Hospital of Fuzhou City from June 2019 to June 2020 were selected as the cerebral infarction group.According to the National Institutes of Health Stroke Scale(NIHSS)score standard,they were divided into good prognosis group (≤21 points,44 cases)and poor prognosis group (22-25 points,36 cases).At the same time,80 healthy people who received physical examination at the same time were selected as the control group.5 ml of fasting cubital vein blood was collected to measure Hcy,PCT and coagulation function indexes,including activated partial thromboplastin time (APTT),prothrombin time (PT),D-Dimer(D-D),fibrinogen(FIB),thrombin time (TT).Hcy,PCT and coagulation function indexes of cerebral infarction group and control group were compared,and Hcy,PCT and coagulation function indexes in good prognosis group and poor prognosis group in cerebral infarction group were compared.The correlation of Hcy,PCT and coagulation function and cerebral infarction was analyzed.Results Hcy,PCT,FIB and D-D in cerebral infarction group were higher than those in control group(P<0.05).Hcy,PCT,FIB and D-D in poor prognosis group were higher than those in good prognosis group,and the differences were statistically significant (P<0.05).Pearson analysis showed there were positive correlations between Hcy、PCT、FIB and D-D and the prognosis of NIHSS scores in patients with cerebral infarction (P<0.05).Conclusion The combined detection of Hcy,PCT and coagulation function has positive significance for the clinical diagnosis of patients with cerebral infarction,and also helps to analyze and evaluate the prognosis of patients. 2021 Vol. 28 (32): 169-172 [Abstract] ( 52 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 173 Application of PCR fluorescence probe method combined with DNA micro-display chip method in the diagnosis and treatment of pulmonary tuberculosis WANG Xiao-hong Objective To explore the application effect of PCR fluorescence probe method combined with DNA microdisplay chip method in the diagnosis and treatment of pulmonary tuberculosis.Methods A total of 128 patients with pulmonary tuberculosis admitted to Shangrao Second People′s Hospital from January to October 2020 were selected as the observation group.Meanwhile,40 patients without pulmonary tuberculosis were selected as the control group.Morning sputum of the two groups were collected for detection of Mycobacterium tuberculosis using acid-fast staining of sputum smear,serum tuberculosis antibody and PCR fluorescent probe.Then DNA micro-display chip method was used to detect drug resistance of Mycobacterium tuberculosis.The diagnostic efficiencies of the three methods were compared,and the results of rifapicin isoniazid resistance detection by DNA microarray chip method were analyzed.Results The sensitivity,specificity,positive predictive value and accuracy of PCR fluorescence probe in the diagnosis of tuberculosis were higher than those of acid-fast staining of sputum smear and serum tuberculosis antibody testing,with statistically significant differences(P<0.05).DNA micro-display chip method found 45 cases sensitive to rifampicin,11 cases resistant to rifampicin,44 cases sensitive to isoniazid,12 cases resistant to isoniazid,and 5 cases resistant to both drugs.Conclusion PCR fluorescence probe method combined with DNA micro-display chip method can not only increase the detection rate of Mycobacterium tuberculosis,but also quickly detect the drug resistance of Mycobacterium tuberculosis,and the diagnosis and drug resistance results can be obtained within 48 hours,thereby assisting in early diagnosis and development of effective treatment plans,which is of great significance for improving the prognosis of patients with pulmonary tuberculosis. 2021 Vol. 28 (32): 173-175转179 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 176 Analysis of severe lipemia interfering partial biochemical indicators detected by dry and wet chemical methods ZHANG Han-yun；LI You-qiang；DENG Yu-jie；WANG Jing-jing；GAN Zhao-xing；ZENG Fan-xing；CHEN Xi-quan Objective To compare the anti-interference ability of dry chemical method with that of wet chemical method on severe lipemia,the results of 14 biochemical indicators of lipemia specimens before and after high-speed centrifugation detected by the dry and wet chemical instruments were observed.Methods A total of 41 cases of clinical severe lipemia specimens were collected.After routine centrifugation,14 biochemical indicators which included aspartate aminotransferase (AST),creatine kinase (CK),creatine kinase isoenzyme MB (CK-MB),amylase(AMY),lactate dehydrogenase(LDH),cholinesterase(CHE),Urea,creatinine(Cr),HCO3-、glucose(Glu),Ca2+,K+,Na+and Clwere detected by H7600 automatic biochemical analyzer and V5600 dry chemical analyzer,respectively.After highspeed centrifugation,the lower layer of transparent serum was absorbed to detect the above indicators again，and the results before high-speed centrifugation were compared with that after high-speed centrifugation.Results After highspeed centrifugation,there were no statistically significant differences in the results of 3 indicators which included AMY,CK and Ca2+in 41 lipemia specimens detected by H7600 automatic biochemical analyzer(P>0.05),while the differences in the results of other 11 indicators which included AST、CK-MB、LDH、CHE、Urea、Cr、HCO3-、Glu、K+、Na+and Cl-were statistically significant(P<0.05).After high-speed centrifugation,there were no statistically significant differences in the results of 8 indicators which included AMY、CK、Ca2+、AST、LDH、Urea、Cr and K+in 41 lipemia specimens detected by V5600 dry chemistry analyzer(P>0.05),while the differences in the results of the other 6 indicators which included CK-MB、CHE、HCO3-、Glu、Na+and Cl-were statistically significant(P<0.05).Conclusion The antiinterference ability of dry chemical method against severe lipemia is better than that of wet chemical method in some biochemical indicators.It is recommended that severe lipemia specimens be detected after high-speed centrifugation for the accuracy of the results. 2021 Vol. 28 (32): 176-179 [Abstract] ( 54 ) HTML (38 KB)  PDF  (0 KB)  ( 9 ) 180 Analysis of birth defects of gestational age less than 28 weeks in Fujian Province from 2018 to 2020 LIN Ying-ying；ZHU Wen-bin；LIN Juan；XIU Xiao-yan；YAN Jian-ying Objective To analyze the birth defects of gestational age less than 28 weeks in Fujian Province from 2018 to 2020,and provide basis for comprehensive prevention and treatment of birth defects.Methods Clinical data of perinatal infants from 103 hospitals in the birth defect surveillance system of Fujian Province from January 2018 to December 2020 were collected,and various data of birth defects of gestational age less than 28 weeks were statistically analyzed.Results From 2018 to 2020,a total of 795 475 perinatal infants and 31 475 birth defects were monitored,of which 7241 cases had a gestational age less than 28 weeks (23.01%).The therapeutic induction rate of infants with birth defects of gestational age less than 28 weeks was 97.51%.Most malformation was diagnosed prenatally and mainly based on ultrasound or chromosomes,with the main outcome was generally stillbirth.Birth defects of gestational age less than 28 weeks differed greatly in maternal age,usual residence and fetal gender.The incidence of birth defects was higher among women with advanced age,urban residents and male infants,with the differences were statistically significant(P<0.001).The five major types of birth defects of gestational age less than 28 weeks were congenital heart disease,the cleft lip with or without cleft palate,Down′s syndrome,neural tube defects and umbilical bulge.Conclusion Birth defects of gestational age less than 28 weeks are mainly severely lethal and disabling birth defects.Comprehensive consideration,along with prevention and control strategies,should be given to the characteristics of birth defects of different gestational ages. 2021 Vol. 28 (32): 180-183 [Abstract] ( 48 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 184 Analysis of social function status in patients with schizophrenia and its influencing factors LIU Qiu-lan；WU Wen-yan Objective To explore the social function status in patients with schizophrenia and its influencing factors.Methods A total of 76 patients with schizophrenia who received treatment in Ji′an Third People′s Hospital from August 2018 to August 2020 were selected as the research objective.The social function of all patients was evaluated according to the social functional rafing scale(SFRS),and the influencing factors of low social function in patients with schizophrenia were analyzed.Results A total of 76 patents after SFRS assessment,there were 31 patients had low social function,accounting for 40.79%,and 45 patients had good social function,accounting for 59.21%.The results of logistic regression analysis test showed that female (β=3.296,OR=27.000,95%CI=7.514-97.025),hospitalization times ≥3 times (β=3.486,or=32.667,95%CI=9.701-96.684),low degree of disease cognition (β=2.014,OR=15.796,95%CI=4.257-36.740),high score of extravertebral side effects (β=2.749,OR=21.307,95%CI=6.226-53.281)were the risk factors of low social function in patients with schizophrenia(OR>1,P<0.05).The degree of disease cognition(β=-1.074,OR=0.342,95%CI=0.200-0.582)was the protective factor of social function in patients with schizophrenia,the higher the degree of disease cognition,the better the social function of patients(OR>1,P<0.05).Conclusion A part of patients with schizophrenia have low social function,and female,hospitalization times≥3 times,low degree of disease cognition,high score of extravertebral side effects are the risk factors of low social function in patients with schizophrenia,at the same time,the degree of disease cognition is the protective factor of social function,targeted preventive measures can be implemented according to the risk factors in clinic,in order to improve the social function of patients. 2021 Vol. 28 (32): 184-187 [Abstract] ( 57 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 188 Cognition survey and influencing factors analysis of parents of children hepatitis B vaccinated WANG Ping；ZHANG Ping；LIU Qi Objective To investigate and analyze the cognition situation and influencing factors of parents of children vaccinated with hepatitis B vaccinated.Methods A questionnaire about hepatitis B vaccination was conducted among the parents of 60 children who received hepatitis B vaccination in the Third People′s Hospital of Pingxiang City from January 2020 to April 2021.According to the parents′cognitive level,the subjects were divided into a high cognitive level group(n=44)and a low cognitive level group(n=16).To analyze the influencing factors of parents′cognition level on hepatitis b vaccination.Results Parents aged Patients>40 years old (β=0.834，P<0.05，OR=2.303，95%CI=1.348-3.932),with educational level below junior middle school level(β=0.977，P<0.05，OR=2.656，95%CI=1.335-5.285),and those whose domicile was foreign (β=0.876，P<0.05，OR=2.401，95%CI=1.288-4.478),and ignorance of domestic vaccine events (β=0.784，P<0.05，OR=2.190，95%CI=1.030-4.658)were all factors influencing parents′cognition about hepatitis B vaccination.Conclusion By analyzing the factors affecting parents′awareness of hepatitis B vaccination,it is found that age>40 years old,education level of junior high school or below,household registration in a foreign country,and lack of knowledge of domestic vaccine incidents are all factors that lead to their low level of awareness.Risk factors,clinical measures can be taken to improve parents′awareness of hepatitis B vaccination,to increase the vaccination rate. 2021 Vol. 28 (32): 188-190 [Abstract] ( 55 ) HTML (26 KB)  PDF  (0 KB)  ( 7 ) 191 Effect of improved tube sealing method to prevent peripheral vein indwelling needle from blocking the tube in oncology patients ZHANG Jie-ling；HUANG Fen Objective To explore the effect of improved sealing method in preventing blockage of peripheral venous indwelling needle in oncology patients.Methods A total of 300 patients who underwent peripheral venous indwelling needle in the Second Affiliated Hospital of Nanchang University from March 2019 to February 2020 were selected as research objects.They were divided into the control group and the experimental group according to the order of puncture catheterization,150 cases in each group.After the tube was placed,the experimental group underwent modified tube sealing technique and the control group underwent the conventional approach.The two groups were compared concerning the incidences of blood back flow,blockage 24 hours after closure and the average indwelling time.Results The incidences of blood back flow and blocked tube in experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).The catheter life-time of experimental group was longer than that of control group,the difference was statistically significant(P<0.05).The total incidence of phlebitis in experimental group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The improved sealing method can effectively prevent the occurrence of peripheral venous indwelling needle occlusion and prolong the indwelling time of the catheter in oncology patients 2021 Vol. 28 (32): 191-194 [Abstract] ( 58 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 195 Application value of mobile home care platform in improving the quality of gestational diabetes mellitus follow-up management HE Qiu；ZHOU Tong Objective To explore the application effect of mobile home care platform in the follow-up management of gestational diabetes mellitus (GDM).Methods A total of 96 GDM patients treated in Yichun Maternity and Child Health Hospital from January to May 2021 were selected as objects of study.They were divided into the control group(48 cases)and the observation group (48 cases)according to random number table method.The control group received routine follow-up management,while the observation group adopted the mobile home nursing platform to intervene.The two groups were followed up to the patients after delivery.The blood glucose control effect,quality of life and pregnancy outcome were compared between the two groups.Results After the intervention,the fasting blood glucose and 2-hour postprandial blood glucose levels in the observation group were(3.41±0.57)and(6.88±1.52)mmol/L respectively,which were lower than those in the control group of(3.98±0.65)and(7.85±1.70)mmol/L;the score of quality of life was(70.70±15.82)points,which was higher than that in the control group of(62.63±14.79)points,the total incidence of adverse pregnancy outcome was 4.17% lower than that in the control group of 18.75%,the differences were statistically significant(P＜0.05）.Conclusion Mobile home care platform has a high application value in the follow-up management of GDM,which is beneficial to improving the effect of blood sugar control,improving the quality of life and improving the outcome of pregnancy. 2021 Vol. 28 (32): 195-197转201 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 198 Peycho educational program in patients with initial insulin treatment of type 2 diabetes ZHONG Mei-lan；WANG Chun-xia Objective To investigate the application of structured peycho education program (PEP)in insulin therapy for type 2 diabetes （T2DM）patients.Methods From January 2018 to January 2019,100 patients with T2DM were admitted to the Fourth Affiliated Hospital of Nanchang University were selected and divided into the observation group(50 cases)and the control group(50 cases)by random digital table method.The control group was given traditional nursing care,based on the control group,the observation group was given regular guidance PEP the project plan.The exercise of self-care agency sccale(ESCA)score and minnesota living with heart failure questionnaire(MLHFQ)score were analyzed and compared between the two groups.Results The ESCA score in the observation group was higher than that in the control group after 3 months of nursing,and the MLHFQ score was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion The nursing effect of the PEP program in T2DM patients treated with insulin is remarkable,it can become a new method with application prospect. 2021 Vol. 28 (32): 198-201 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 202 Application effect of nursing intervention of traditional Chinese medicine encapsulation in patients with epigastric pain TANG Hai-yan HE QiWEN Qin Objective To investigate the application effect of nursing intervention of traditional Chinese medicine encapsulation in patients with epigastric pain.Methods A total of 92 patients with epigastric pain admitted to Ruichang Hospital of Traditional Chinese Medicine from February 2020 to February 2021 were selected as the research objects,and were divided intot he control group (46 cases)and the observation group (46 cases)by random number table method.The two groups were treated with conventional western medicine,the control group was added with conventional nursing intervention,and the observation group was treated with nursing intervention of traditional Chinese medicine on the basis of the control group.The intervention effect and clinical symptom disappearance time were compared between the two groups.Results The total effective rate of the observation group was 95.65%,higher than 82.61% of the control group,with statistical difference (P<0.05).The disappearance time of symptoms of epigastriac pain,vomiting water,cold limbs and symptoms in the observation group were(4.03±0.69),(3.96±0.52),(5.12±1.08)and(3.48±0.46)d,which were shorter than(5.71±1.12),(4.87±1.03),(6.52±1.13)d and(4.31±0.57)d in the control group,with statistical differences (P<0.05).Conclusion The nursing intervention of traditional Chinese medicine encapsulation can enhance the intervention effect of epigastric pain,accelerate the disappearance of clinical symptoms and alleviate the suffering of patients. 2021 Vol. 28 (32): 202-204 [Abstract] ( 53 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 205 Application of self-made glove restraint belt in anesthesia recovery room after general anesthesia in children XIAO Fang-fang Objective To explore the application effect of self-made glove restraint band in the recovery room of anesthesia after general anesthesia in children.Methods To design and make a safe,effective and easy to use self-made glove restraint band for the restraint and fixation of children in the recovery period after general anesthesia.A total of 60 cases of children with agitation who received treatment in the Anesthesia Room of Pingxiang People′s Hospital from May 2019 to July 2020 were selected as the research objects.According to the drawing method,they were divided into the experimental group(30 cases)and the control group(30 cases).The experimental group was treated with glove restraint band,while the conventional group was treated with traditional restraint band.The effectiveness of constraints,the incidence of complications with constraints and family satisfaction were compared between the two groups.Results The total incidence of complications in the experimental group was lower than that in the conventional group,the difference was statistically significant(P＜0.05).The comfort degree and the degree of family satisfaction of children in the experimental group were better than those in the conventional group,and the differences were statistically significant(P＜0.05).The visual analogue scale(VAS)score of the experimental group was(3.2±0.3)points,which was lower than that of the control group([5.8±0.6]points),and the difference was statistically significant(P＜0.05).Conclusion The effect of self-made glove restraint band in clinical application is obviously better than that of traditional restraint band,which increases the sense of security and comfort of children,and it is worthy of clinical promotion and application. 2021 Vol. 28 (32): 205-207 [Abstract] ( 48 ) HTML (29 KB)  PDF  (0 KB)  ( 10 ) 208 Influence of WeChat group discharge care in the blood glucose management of diabetic patients and its influence on patients′blood glucose and negative emotions WANG Hong-yan；HU Qing-di；JIAN Dong-mei Objective To explore the influence of WeChat group discharge care on blood glucose management of diabetic patients.Methods A total of 101 diabetic patients treated in Xinyu Fourth Hospital in Jiangxi Province from November 2018 to March 2019 were selected for retrospective analysis.According to different intervention methods,the patients were divided into the observation group(n=60)and the control group(n=41).In the control group,basic nursing intervention was provided.In the observation group,basic nursing and WeChat group discharge care were provided.The two methods on the self-management behavior,blood glucose level,the patients′satisfaction on staff and the negative emotions of the two groups of patients were compared.Results Before receiving nursing care,summary of diabetes self-care activities (SDSCA)score,fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin level,self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score between the two groups were compared,and there were no statistical significance (P＞0.05).After receiving nursing care,the SDSCA score in the observation group was higher than that of the control group,with statistical difference (P<0.05).After receiving nursing care,the fasting blood glucose,2 h postprandial blood glucose,and glycated hemoglobin level of the observation group were lower than those of the control group,with statistical differences(P<0.05).After receiving nursing care,the service attitude,professional skills,verbal communication and health education scores of the observation group were higher than those of the control group,with statistical significance (P<0.05).After receiving nursing care,the SAS and SDS scores of patients in the observation group were lower than those of the control group,with statistical differences (P<0.05).Conclusion To certain extent,WeChat group discharge care can effectively strengthen patients′self-discipline ability,improve patients′blood glucose status,and increase patients′satisfaction with treatment in this hospital. 2021 Vol. 28 (32): 208-211 [Abstract] ( 56 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 212 Effect of combination of evidence-based medicine strategy and humanbased nursing on comfort,nursing satisfaction and quality of life in patients with intestinal obstruction during gastrointestinal decompression TANG Li-juan；GUO Yong Objective To explore the effect of evidence-based medicine strategy combined with human-based nursing on comfort,nursing satisfaction and quality of life in patients with intestinal obstruction during gastrointestinal decompression.Methods A total of 82 patients with intestinal obstruction admitted to Ezhou Second Hospital in Hubei Province from October 2019 to October 2020 were selected as the research objects.They were divided into the observation group(41 cases)and the control group(41 cases)according to the random number table method.The control group was used routine nursing intervention,the observation group was used evidence-based medicine strategy combined with human-based nursing,the comfort,nursing satisfaction,and quality of life between the two groups were compared.Results The general comfort question (GCQ)score of the two groups after intervention were higher than those before the intervention,and the GCQ score of the observation group was higher than that of the control group,and the differences were statistically significant(P＜0.05）.The Newcastle nursing satisfaction scale(NSNS)after the intervention of the two groups were higher than those before the intervention,the NSNS score of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).The generic quality of life Inventory-74(GQOL-74)scores of the two groups after the intervention were higher than those before the intervention,the GQOL-74 score of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Evidence-based medicine strategy combined with human-based nursing during gastrointestinal decompression for patients with intestinal obstruction can improve patients′comfort and nursing satisfaction,improve patients′quality of life,and have high application value. 2021 Vol. 28 (32): 212-215 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 216 Clinical effect of comprehensive nursing on prevention of DVT thrombosis in patients with AMI in Coronary Care Unit XU Meng-meng Objective To explore the clinical effect of comprehensive nursing on the prevention of DVT thrombosis in patients with acute myocardial infarction (AMI)in CCU.Methods A total of 88 patients with clinically diagnosed AMI who admitted to the First Affiliated Hospital of Bengbu Medical College from January to December 2020 were selected.According to the sequence of admission time,they were divided into the control group (44 cases)and the observation group(44 cases).The control group received routine clinical nursing and the observation group received comprehensive nursing.The coagulation indicators(prothrombin time[PT],activated partial thrombin time[APTT],D-dimer[D-dimer],fibrinogen [FBG],etc.),incidence of lower extremity DVT and nursing satisfaction of the two groups were compared.Results The incidence of lower limb DVT in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There were no difference in coagulation indicators(such as PT,APTT,D-dimer,FBG etc.)before nursing between the two groups(P＞0.05).After nursing,PT,APPT,D-dime,FBG of the observation group were lower than before nursing,APPT ot the control group was lower than before nursing,PT,APPT,D-dime,FBG of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The nursing total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Comprehensive nursing is helpful to reduce the incidence of lower limb DVT,the coagulation indicators,nursing quality and satisfaction in patients with AMI of CCU. 2021 Vol. 28 (32): 216-218转222 [Abstract] ( 55 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 219 Risk factors and nursing countermeasures of rapid rehabilitation nursing for precision liver resection ZHENG Xiao；XU Xi；WEI Ying Objective To discuss the risk factors and nursing countermeasures of rapid rehabilitation nursing for precision liver resection.Methods A retrospective selection of 44 patients who underwent precision liver resection and rapid rehabilitation care in the Affiliated Hospital of Jiujiang University from January 2018 to March 2019 were selected as the control group,and were divided into a good prognosis group (26 cases)and a poor prognosis group based on the nursing effect group (18 cases),and then from June 2019 to October 2020,a total of 30 patients with optimized precision liver resection and rapid rehabilitation care at the Affiliated Hospital of Jiujiang University served as the research group.Patients in the control group were given rapid rehabilitation care for precision liver resection,and patients in the study group were given rapid rehabilitation care for optimized precision liver resection.Calculate the basic clinical data of the two groups and conduct single-factor analysis,conduct multi-factor unconditional logistic regression analysis on related risk factors that affect precision liver resection and rapid rehabilitation care,and discuss nursing strategies.Results Univariate analysis showed that the poor prognosis group had ASA gradeⅢ-Ⅳ,total bilirubin (TBil)>21 μmol/L,alanine aminotransferase(ALT)>50 U/L,activated partial thromboplastin time(APTT)>40.0 s,blood transfusion and intraoperative blood loss>400 ml,the proportion of patients with good prognosis were higher than those of the good prognosis group,the differences were statistically significant(P<0.05);the results of multivariate analysis indicated that ASA grade Ⅲ-Ⅳ,TBIL>21 μmol/L,ALT>50 U/L,APTT>40.0 s,blood transfusion and intraoperative blood loss>400 ml were all precision liver resection rapid rehabilitation care plans Risk factors for failure (P<0.05).The postoperative anal exhaust time and hospital stay in the research group were shorter than those in the control group,the differences were statistically significant(P<0.05).The Connor-Davidson resilience scale (CD-RISC)scores after nursing in the research group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Formulating nursing strategies for risk factors and optimizing precise liver resection and rapid rehabilitation nursing methods can help shorten the treatment time of patients,alleviate the patients′bad mood,and promote the recovery of the disease. 2021 Vol. 28 (32): 219-222 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 223 Effect of a small low frequency therapeutic apparatus combined with Chinese herbal package on uterus and holistic nursing on promoting postpartum uterine contraction LIU Jian-ying；ZENG Shu-hua；XU Chun-di Objective To analyze the therapeutic effect of uterine contractions after delivery of parturients by using a small low frequency therapeutic apparatus combined with Chinese herbal package on uterus and holistic nursing.Methods Sixty-six clinical cases of postpartum women who were admitted to Ruijin Maternity and Child Health Hospital from July to December 2020 were selected as the research subjects.They were divided into a control group and an observation group according to the random number table method,with 33 cases in each group.The control group used conventional nursing,manual uterine massage,and uterine contraction injection methods,and the observation group used low-frequency therapy instrument combined with traditional Chinese medicine to seal the uterus and holistic nursing methods.The pain degree of postpartum uterine contraction,the duration of contraction pain,and the amount of postpartum vaginal bleeding between the two groups were compared between the two groups.Results The pain of uterine contractions and vaginal bleeding in the observation group at 6,12,24,and 48 h were lower than those of the control group,and the differences were statistically significant(P＜0.05).The comparison between the observation group and the control group in terms of pain degree of uterine contractions and vaginal bleeding between groups,time point and time point,and group time point interaction,the difference was statistically significant(P<0.05).The duration of pain reduction in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The combination of a small low frequency therapeutic apparatus,Chinese herbal package on uterus,and holistic nursing can effectively alleviate the pain of postpartum contractions,promote uterine contractions,facilitate uterine recovery,reduce postpartum hemorrhage rate,relieve maternal pain,and make women feel safe and healthy in body and mind,which has good social and economic benefits,and can be used for clinical promotion and application. 2021 Vol. 28 (32): 223-226 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 227 Intervention effect of clustered nursing combined with personalized nutritional support on patients with severe stroke ZHENG Lan-lan Objective To explore intervention effect of clustered nursing combined with personalized nutritional support on patients with severe stroke.Methods A total of 60 patients with severe stroke who were admitted to Shangrao Municipal Hospital from May 2019 to December 2020 were selected as the research subjects,and they were divided into the control group(30 cases)and the study group(30 cases)according to the random number table method.The control group was given routine nursing and nutritional support,and the study group was given clustered nursing and personalized nutritional support.The patient′s serum hemoglobin(Hb),blood lipid levels,nutritional indexes before and after nursing,and complications during nursing were compared.Results Serum Hb,triacylglycerol(TG),total cholesterol(TC),triceps skinfold thickness(TSF),upper arm muscle circumference(AMC),body mass index(BMI)levels of patients in the study group after nursing were lower than those in the control group,and the differences were statistically significant(P<0.05);the total incidence of complications during the nursing period of the study group was 6.67%,which was lower than the 26.67% of the control group,and the difference was statistically significant(P<0.05).Conclusion Clustered nursing combined with personalized nutritional support can effectively restore the serum hemoglobin and blood lipid levels of patients with severe stroke,improve the nutritional status of patients,reduce the incidence of complications,and enhance the effect of intervention. 2021 Vol. 28 (32): 227-229转233 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 230 Application effect of detailed nurse and cognitive intervention in the treatment of uterine scar pregnancy with focused ultrasound LIN Jia-mei；CHEN Jian-ying；HUANG Gui-rong Objective To discuss the application effect of detailed nurse and cognitive intervention in the treatment of uterine scar pregnancy with focused ultrasound.Methods 80 cases of uterine scar pregnancy ultrasound focused treatment patients admitted in Yangjiang Maternity and Child Health Hospital,Guangdong Province from January 2020 to January 2021 were selected and divided into the control group(n=40)and the observation group(n=40)by random envelope method.The control group carried out routine perioperative nursing,and the observation group used detailed nursing combined with cognitive intervention.Negative emotions before and after nursing were compared between the two groups,and treatment compliance and satisfaction with nursing service were evaluated after nursing.Results The self-rating anxiety scale(SAS)and self-rating depression scale(SDS)scores of the two groups after nursing were lower than those before nursing,and SAS and SDS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05）;the treatment compliance of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05）;the nursing total satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05）.Conclusion Perioperative detailed nursing combined with cognitive intervention can improving the negative emotion of patients with uterine scar pregnancy ultrasound focused treatment,and improving their treatment compliance and nursing satisfaction.It is worthy of application and promotion. 2021 Vol. 28 (32): 230-233 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 234 Analysis of the effect of acupoint massage combined with emotional nursing on blood pressure control in patients with hypertension FU Xin-yu Objective To analyze the effect of acupoint massage combined with emotional nursing on blood pressure control in patients with hypertension.Methods 158 cases of hypertensive patients accepted in Fushun Hospital of Traditional Chinese Medicine from February 2020 to February 2021 were selected as the research objects,and they were divide into the control group(79 cases)and the experiment group(79 cases)by random number table method.The control group was given acupoint massage,the experimental group was given acupoint massage combined with emotional nursing.The blood pressure control effect,negative emotion and self-efficacy of the two groups of patients were compared.Results After intervention,the diastolic and systolic blood pressure levels of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).The self-rating anxiety scale(SAS)score and self-rating depression scale(SDS)score of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).The GSES score of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Acupoint massage combined with emotional care has a significant effect in the application of hypertensive patients,which can improve their blood pressure control effect,relieve negative emotions,and promote self-efficacy. 2021 Vol. 28 (32): 234-236转240 [Abstract] ( 50 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 237 The preventive and nursing effect of intermittent air pressure therapy instrument on deep vein thrombosis in ICU HUANG Jin-pen Objective To explore the effect of intermittent barotherapy in the prevention and nursing of deep venous thrombosis in ICU.Methods 76 ICU patients in Xiamen Hospital of Traditional Chinese Medicine from September 2019 to July 2020 were selected as the research objects.They were divided into the control group (38 cases)and the observation group(38 cases)according to random number table method.The control group implemented routine preventive nursing measures.The observation group added deep venous thrombosis therapeutic instrument on the basis of the control group.The blood flow velocity,peripheral diameter and incidence of DVT of lower extremity in the two groups were compared.Results there was no significant difference in the blood flow velocity of lower extremity deep vein between the two groups before intervention(P＞0.05).The blood flow velocity of lower extremity deep vein in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the degree of peripheral diameter swelling of lower limbs between the two groups before intervention (P＞0.05).The degree of peripheral diameter swelling of lower limbs in the observation group was less than that in the control group after 7 days of intervention,the difference was statistically significant(P<0.05).The incidence of lower limb DVT in the observation group was 2.63%,which was lower than 21.05% in the control group,the difference was statistically significant(P<0.05).Conclusion Intermittent barotherapy instrument has a good application effect in the prevention and nursing of DVT in ICU patients.It is conducive to accelerate the blood flow velocity of deep veins of lower limbs,reduce the peripheral diameter swelling of lower limbs and reduce the incidence of DVT of lower limbs. 2021 Vol. 28 (32): 237-240 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )

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