Claudin-1、E-cad、CyclinD1和 nm23在不同分化肺腺癌中的表达及临床意义

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Abstract Objective To investigate the expression of Claudin-1,E-Cadherin (E-cad),CyclinD1 and non-metastatic 23 (nm23)in different differentiated lung adenocarcinoma cells,and to explore their correlation with the degree of differentiation and prognosis of lung adenocarcinoma.Methods From March 2013 to March 2017,the lung adenocarcinoma tumor tissue specimens and normal tissue specimens adjacent to the lung adenocarcinoma of 60 patients undergoing lung adenocarcinoma surgery admitted to the Clinic Pathology Diagnosis Center of Qiqihar Medical College were selected as the research objects.The tumor tissue samples were set as the experimental group,and the normal tissue samples adjacent to the lung adenocarcinoma were set as the control group.According to the morphological characteristics of light microscopy,lung adenocarcinoma tumor tissue samples were divided into high differentiation,medium differentiation and low differentiation.Immunohistochemical staining was used to detect the expressions of Claudin-1,E-CAD,CyclinD1 and nm23 in cancer,adjacent and normal tissues.Samples were respectively obtained from cancer,paracancerous and normal lung tissues.Immunohistochemical staining was implemented to detect the expression of Claudin-1,E-cad,nm-23 and CyclinD1.Results The expressions of E-cad and nm23 in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CyclinD1 and Claudin-1 in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).The expression of E-cad and nm23 in highly differentiation was higher than that in low differentiation,and the differences were statistically significant(P<0.05).The expression of CyclinD1 and Claudin-1 in highly differentiation was lower than that in low dif-ferentiation,and the differences were statistically significant(P<0.05).Conclusion Claudin-1,E-cad,nm23 and CyclinD1 play an antagonistic role in the occurrence and development of tumors,which affect the evolution of tumors.They can be used as auxiliary indicators for histological classification,clinical stage and prognosis.

Key words： Claudin-1 E-cadherin Non-metastatic 23 CyclinD1 Lung adenocarcinoma Immunohistochemical staining

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	Articles by authors
	YANG Bai-lu
	LI Zi-yan
	ZHANG Yan-wei
	XIE Yong
	CAO Di
	BAI Qing-yang

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YANG Bai-lu,LI Zi-yan,ZHANG Yan-wei, et al. Expression and clinical significance of claudin-1，E-cad，CyclinD1 and nm23 in different differentiated lung adenocarcinoma[J]. 中国当代医药, 2021, 28(32): 37-39转44.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I32/37

[1]	陈金东.中国各类癌症的发病率和死亡率现状及发展趋势[J].遵义医学院学报，2018，41（6）：653-662.
[2]	肖佳龙，郑莹.全球肺癌的流行及预防进展[J].中国癌症杂志，2020，30（10）：721-725.
[3]	刘相良，袁铭成，纪伟，等.长链非编码RNA在肺癌发生发展中作用的研究进展[J].吉林大学学报：医学版，2017，43（2）：450-453.
[4]	杨云英，王雪涔，彭振维，等.基于生物信息学途径预测MELK基因在肺腺癌及肺鳞癌中的功能机制及临床意义[J].中山大学学报（医学科学版），2020，41（6）：891-901.
[5]	季蓉，朱小娟，郭海莲，等.紧密连接蛋白-1功能研究进展[J].中国细胞生物学学报，2020，42（9）：1617-1623.
[6]	Morin PJ.Claudin proteins in human cancer：promising new targets for diagnosis and therapy[J].Cancer Res，2005，65（21）：9603-9606.
[7]	郭宁宁.非小细胞肺癌EGFR基因突变与E-cadherin、Vimentin表达的相关性[J].内蒙古医科大学学报，2020，42（3）：257-260.
[8]	盛亚，熊艳丽，许明芳，等.nm23-H1核内定位对人肺腺癌A 549 细胞增殖的影响[J].中国肺癌杂志，2017，20（4）：226-232.
[9]	Li J，Liao P，Wang K，et al.Calcium Sensing Receptor Inhibits Growth of Human Lung Adenocarcinoma Possibly via the GSK3β/Cyclin D1 Pathway[J].Front Cell Dev Biol，2020，10（8）：89-94.
[10]	Nasako H，Takashina Y，Eguchi H，et al.Increase in Toxicity of Anticancer Drugs by PMTPV，a Claudin-1-Binding Peptide，Mediated via Down-Regulation of Claudin-1 in Human Lung Adenocarcinoma A549 Cells[J].Int J Mol Sci，2020，21（16）：45-49.
[11]	Dhawan P，Singh AB，Deane NG，et al.Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer[J].J Clin Invest，2005，115（7）：1765-1776.
[12]	王晔恺，周吉航，曾芳.非小细胞肺癌患者紧密连接蛋白-1基因启动子甲基化分析及其临床意义[J].右江医学，2015，43（1）：97-100.
[13]	Sun BS，Yao YQ，Pei BX，et al.Claudin-1 correlates with poor prognosis in lung adenocarcinoma[J].Thorac Cancer，2016，7（5）：556-563.
[14]	Zhao Z，Li J，Jiang Y，et al.CLDN1 Increases Drug Resistance of Non-Small Cell Lung Cancer by Activating Autophagy via Up-Regulation of ULK1 Phosphorylation[J].Med Sci Monit，2017，23（4）：2906-2916.
[15]	夏露花.nm23表达在NSCLC中的研究及PET/CT对其分期与放疗计划的影响[D].乌鲁木齐：新疆医科大学，2020.
[16]	黄虎，栗娜，杨柳，等.非小细胞肺癌组织中 NF-κB和CyclinD1及p27表达与患者化疗敏感性[J].贵州医科大学学报，2019，44（2）：195-199.
[17]	翁绳和.肺腺癌分化程度的相关因素分析[J].中国医药科学，2020，10（4）：243-246.