非小细胞肺癌患者肿瘤微环境中TAMs及PD-1表达水平及与临床预后的关系

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Abstract Objective To investigate the expression of tumor-associated macrophages (TAMs)and programmed death receptor-1(PD-1)in the tumor microenvironment of patients with non-small cell lung cancer(NSCLC)and their relationship with the prognosis of patients.Methods A total of 76 patients with NSCLC who were diagnosed for the first time in the Department of Thoracic Surgery of the First People′s Hospital of Jiujiang City from January 2019 to December and were undergoing elective surgery were selected as the research objects.The cancer tissues and adjacent tissues were collected during the operation,and the TAMs phenotype and PD-1 expression level were analyzed by immunohistochemistry,the clinical prognostic factors of the patients were collected,the 1-year survival rate was observed,and the TAMs phenotype and PD-1 expression level distribution characteristics under different clinical prognostic factors were analyzed.COX regression were used to analysis the risk factors of patients′death within 1 year.Results The positive expression of PD-1 and CD206 in NSCLC were higher than those in the adjacent tissues,and the positive expression of CD86 was lower than that of the adjacent tissues,and the differences were statistically significant (P<0.05).The positive expression of PD-1 and CD206 in cancer tissues was positively correlated (P＜0.05).The positive expression level of PD-1 in adenocarcinoma was higher than that of squamous cell carcinoma,and the difference was statistically significant(P<0.05).The expression level of well-differentiated CD86 was higher than that of poorly differentiated and moderately differentiated,and the difference was statistically significant(P<0.05).The expression of well-differentiated and moderately differentiated CD206 were lower than that of low-differentiation differentiation,and the differences were statistically significant(P<0.05).The positive expression level of PD-1 in clinical stage Ⅲ and Ⅱ were higher than that in stage Ⅰ,and the differencs were statistically significant(P<0.05).The positive expression level of CD86 in clinical stage Ⅲ and Ⅱ were lower than that in stage Ⅰ,and the differences were statistically significant(P<0.05).The expression level of CD206 in patients with invasive growth was higher than that in non-invasive growth,and the difference was statistically significant(P<0.05).The 1-year survival rate of 76 NSCLC patients was 76.32%.PD-1(β=0.031,RR=1.031,95%CI=1.007-1.056)and CD206(β=0.066,RR=1.068,95%CI=1.013-1.127)were risk factors for the 1-year survival rate of NSCLC patients(P<0.05).Conclusion The expressions of PD-1,CD86 and CD206 in NSCLC cancer tissues and adjacent tissues are significantly different.The high expression of PD-1 and the high infiltration characteristics of M2 macrophages can significantly increase the mortality of patients within one year.

Key words： Non-small cell lung cancer Microenvironment Programmed death receptor-1 CD86 CD206 Expression Prognosis

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	ZHANG Jia-xiu
	DENG Lin-feng
	SHI Jian-bang
	WU Jian-wei

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ZHANG Jia-xiu,DENG Lin-feng,SHI Jian-bang, et al. Expression levels of TAMs and PD-1 in the tumor microenvironment of patients with non-small cell lung cancer and their relationship with clinical prognosis[J]. 中国当代医药, 2021, 28(32): 4-8.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I32/4

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