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Quick Search     Adv Search 2020 Vol. 27, No. 10 Published: 2020-04-08   4 Effect of serum containing Huangqi Jianzhong Decoction combined with Cisplatin on A549 cell proliferation and expression of E-cadherin and Snail1 in human lung cancer WANG Xiao-fang； YU Dan； LIU Chun-ying Objective To study the effect of serum containing Huangqi Jianzhong Decoction combined with Cisplatin on A549 cell proliferation and expression of E-cadherin and Snail1 in human lung cancer.Methods A549 cell lines were cultured for 48 h with the serum containing Huangqi Jianzhong Decoction combined with different concentrations of Cisplatin(0,2,4,8,16,32,64 μg/ml).Magnetic Tape Terminal(MTT)was used to detect the proliferation inhibition rate of A549 cell lines and determine the optimal concentration of Cisplatin.A549 cell lines were randomly divided into four groups：blank group,traditional Chinese medicine group,Cisplatin group and combination group,in which complete medium,serum containing Huangqi Jianzhong Decoction,Cisplatin,serum containing Huangqi Jianzhong Decoction and Cisplatin were successively used for intervention.After A549 cell lines were cultured for 48 h,the proliferation inhibition rate of A549 cell lines in each group was further detected by MTT.The protein expression levels of Ecadherin and Snail1 in each group were determined by immunohistochemistry(IHC)and Western Blot(WB).The gene expression levels of E-cadherin and Snail1 were determined by realtime-PCR(RT-PCR).Results The research of MTT method showed that the optimal concentration of Cisplatin in combination was 8 μg/ml.The inhibition rate of A549 cell lines in the combination group was higher than that in the Cisplatin group,the traditional Chinese medicine group and the blank group,the differences were statistically significant(P＜0.05).The research of IHC and WB method showed that the expression level of E-cadherin protein of A549 cell lines in the combination group was higher than that in the Cisplatin group,the traditional Chinese medicine group and the blank group,the differences were statistically significant(P＜0.05).And the expression level of the Snail1 protein of A549 cell lines in the combination group was lower than that in the Cisplatin group,the traditional Chinese medicine group and the blank group,with statistically significant differences(P＜0.05).The research of RT-PCR method showed that the gene expression level of E-cadherin of the A549 cell lines in the combination group was higher than that in the Cisplatin group,the traditional Chinese medicine group and the blank group,with statistically significant differences(P＜0.05).The gene expression level of the Snail1 in the A549 cell lines of the combination group was lower than that of the Cisplatin group,the traditional Chinese medicine group and the blank group,the differences were statistically significant(P＜0.05).Conclusion Serum containing Huangqi Jianzhong Decoction combined with Cisplatin can inhibit the proliferation of A549 cell lines,enhance the expression of E-cadherin protein and gene in A549 cells line of human lung cancer,and reduce the expression of Snail1 protein and gene in A549 cells line of human lung cancer. 2020 Vol. 27 (10): 4-8转12 [Abstract] ( 77 ) HTML (52 KB)  PDF  (0 KB)  ( 8 ) 9 Experimental study of precisely locating foreign body in the lung by CTguided puncture injection of medical glue DENG Shi-long ； XIE Yong-wei ； ZHOU Shun-kai ； YANG Jing-rong； CHEN Xing-chi； YANG Sheng-sheng Objective To establish a model of CT-assisted foreign bodies in lungs of Bama miniature pigs with built-in metal guidewire,and explore the model to study the feasibility and safety of medical glue to accurately locate foreign bodies in the lungs by CT-guided puncture injection after thoracoscopic removal of foreign bodies in the lungs.Methods Four Bama miniature pigs were selected,and 2 cm metal guidewire was inserted into the right lung of Bama mini pigs under CT guidance after anesthesia to simulate foreign bodies in the lungs.After using CT scan to determine the location of the foreign body,puncture and injection of medical glue was used to accurately locate the foreign body in the lung,and then the thoracoscopic removal of the foreign body in the lung was performed.Results Four Bama miniature pigs successfully established CT-assisted models for simulating foreign bodies in the lung with metal guidewire embedded in the lungs.The operation time was 6-9 minutes,with an average of(7.50±1.29)minutes.All CT-guided puncture injections of medical glue were used for localization.The operation time was 18-25 minutes,with an average of(21.25±2.99)minutes.Pneumothorax(25%)appeared in one pig after positioning.The amount of pneumothorax was small,untreated,no hemothorax,pulmonary embolism,and other complications.All Bama miniature pigs underwent thoracoscopy removal of foreign bodies in the lungs.The operation time was 46-93 minutes,with an average of(66.00±20.12)minutes.The location of the foreign body during the operation was 7-11 minutes,with an average of(8.75±1.71)minutes.The anatomy confirmed that after dissection of isolated pig lungs,the medical micelles were located beside the foreign bodies in the lungs.The diameter of the micelles was 8-12 mm,with an average of(9.50±1.91)mm.The distance between the micelles and the foreign objects in the lung was 9-13 mm,with an average of(11.00±1.83)mm.The positioning success rate was 100%.Conclusion The CT-assisted model for locating foreign bodies in Bama miniature pigs lungs with metal guidewire built into the lungs is established,and it is confirmed that the model is safe and feasible for CT-guided puncture and injection of medical glue to accurately locate foreign bodies and to perform thoracoscopic removal of foreign bodies in the lungs,which lays the foundation for further clinical application 2020 Vol. 27 (10): 9-12 [Abstract] ( 93 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 13 Clinical effect of early craniotomy in the treatment of Hunt-Hess high grade aneurysmal subarachnoid hemorrhage XIE Fei; LIU Hong-bin; CHEN Zhi-yuan; ZENG Jia-liang; YE Yong-qiang; HAO Jian-qiang; LIU Huan Objective To exlpore the clinical effect of early craniotomy in the treatment of Hunt-Hess high grade aneurysmal subarachnoid hemorrhage,so as to summarize the clinical experience of early operation for aneurysms.Methods The clinical data of 42 patients with Hunt-Hess grade Ⅳ-Ⅴaneurysmal subarachnoid hemorrhage treated in our hospital from July 2013 to December 2017 were retrospectively analyzed.They were divided into early operation group and delayed operation group according to different operation time.There were 26 patients in early operation group(≤72 h)and 16 patients in delayed operation group(＞72 h).The incidence of intraoperative brain swelling in the two groups was counted,and the Glasgow outcome scale(GOS)was used to assess the prognosis of the two groups after discharge.Results The incidence rate of intraoperative brain swelling in patients in the early operation group was higher than that in the delayed operation group,and the difference was statistically significant(P＜0.05).The GOS grade of patients in the early operation group was better than that in the delayed operation group,and the difference was statistically significant(P＜0.05).Conclusion The prognosis of early craniotomy in the treatment of patients with Hunt-Hess high grade aneurysmal subarachnoid hemorrhage is better than that of delayed operation. 2020 Vol. 27 (10): 13-16 [Abstract] ( 87 ) HTML (38 KB)  PDF  (0 KB)  ( 10 ) 17 Pharmacodynamics study of Qingfei Yihuo Capsules in preventing cough,eliminating phlegm and relieving asthma HU Qian; YAN Yu-feng; LIN Jun; ZHAO Chao; WANG Hui-jing Objective To observe the effect of Qingfei Yihuo Capsules in preventing cough,eliminating phlegm and relieving asthma and its possible mechanisms.Methods The clean ICR mice were selected for antitussive and expectorant experiments,and the healthy guinea pigs were selected for antiasthmatic experiments.They were randomly divided into model group,Qingfei Yihuo Capsules doses groups and Diphenhydramine group.The therapeutic effect of Qingfei Yihuo Capsules were observed using models such as the sulfur dioxide induced cough method,the expelling phlegm method with phenol red,and the histamine induced asthma.The possible mechanisms were discussed using the release model of inflammatory factors in A549 cells induced by dextran sulfate sodium salt(DSS).Results The cough incubation period of the mice in the middle and high dose Qingfei Yihuo Capsules group and Diphenhydramine group were longer than those in the model group and low dose group,the frequency of cough within 2 minutes was fewer than that in the model group and low dose group,the differences were statistically significant(P＜0.05).The secretion of phenol red from trachea in the middle and high dose Qingfei Yihuo Capsules group was higher than that in the model group,the difference was statistically significant(P＜0.05).The incubation period of asthma seizure in the middle and high dose Qingfei Yihuo Capsules group was longer than that in the model group and low dose group,the difference was statistically significant(P＜0.05).In the model of cellular inflammation induced by DSS,the interleukin-1β(IL-1β)levels in cell supernatants in the medium and high concentration groups after using Qingfei Yihuo Capsule were lower than those in the DSS model group and low concentration group,with statistically significant differences(P＜0.05).Conclusion Qingfei Yihuo Capsules has significant effects of preventing cough,eliminating phlegm and relieving asthma,and its possible mechanisms might be related with the anti-histamine effect and the inhibition of the release of inflammatory factors. 2020 Vol. 27 (10): 17-20 [Abstract] ( 99 ) HTML (45 KB)  PDF  (0 KB)  ( 7 ) 21 Study on the correlation between pelvic floor dysfunction and abdominal pelvic biodynamics ZHU Qian Pelvic floor dysfunction is a common gynecological disease in women,the main cause is the weakness of the pelvic floor supporting tissue,and displacement of pelvic organs causes the pelvic organs to move or lead to abnormal pelvic organs.In recent years,many researchers have recognized that the occurrence of pelvic floor function and pelvic floor dysfunction is related to abdominal pelvic biodynamics.This article systematically reviews the relevant research data at home and abroad,through the congenital structure and overall function of women′s pelvic floor and related factors of pelvic floor dysfunction,such as congenital heredity,abdominal pelvic surgery,pregnancy,childbirth,and elaborates the correlation with the abdominal pelvic biodynamics,in order to familiarize with the pelvic abdominal biodynamics,which plays an important role in understanding the pelvic floor function and dysfunction and adopting the correct treatment strategy. 2020 Vol. 27 (10): 21-23 [Abstract] ( 82 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 24 Research progress of nuclear factor-κB and peroxisome proliferator-activated receptor-γ in the pathogenesis of rheumatoid arthritis DONG Jian-bin; LI Jin-tian; ZHANG Yi; YANG Na Rheumatoid arthritis(RA)is a chronic,progressive,invasive,systematic and inflammatory autoimmune disease which mainly involves the surrounding joints.It is characterized by high incidence and high disability rate.At present,it is considered that inflammatory reaction is the core link of its pathogenesis.In the course of the disease,inflammation participates in every stage of the disease,leading to heterophysis and pannus proliferation,bone erosion and cartilage destruction.The discovery of anti-inflammatory and pro-inflammatory mechanisms of peroxisome proliferatoractivated receptor-γ(PPAR-γ)and nuclear factor-κB(NF-κB),the pathway that PPAR-γ can induce apoptosis of macrophages by inhibiting NF-κB,and the close relationship between NF-κB and PPAR-γ provides a new direction for the study of RA.In this paper,the situation of PPAR-γ and NF-κB is reviewed. 2020 Vol. 27 (10): 24-27 [Abstract] ( 93 ) HTML (42 KB)  PDF  (0 KB)  ( 9 ) 28 Research progress on clinical significance of exhaled nitric oxide detection in chronic obstructive pulmonary disease LI Zhi-hui; XU Lin Chronic obstructive pulmonary disease(COPD)as a common disease of the respiratory system,has a high incidence and mortality,and its essence is the chronic inflammatory response of the airway and pulmonary tissue.Therefore,evaluating the degree of inflammatory response is crucial for assessing the condition and guiding treatment.However,the comprehensive assessment of pulmonary function and COPD currently used is one-sided in reflecting airway inflammation.In recent years,exhaled nitric oxide as an inflammatory index has been paid attention for its important role of assessing airway inflammation.It has been widely used in the diagnosis and treatment of asthma,but its application value in the diagnosis and treatment of COPD is still unclear.This article reviews the research progress of exhaled nitric oxide detection in the clinical significance of COPD. 2020 Vol. 27 (10): 28-31 [Abstract] ( 99 ) HTML (42 KB)  PDF  (0 KB)  ( 11 ) 32 Research progress of diagnosis and treatment of multiple primary lung cancer MA Yi-xiang; SHANG Xue-qian; ZHAO Hu Multiple primary lung cancer(MPLC)is a rare type of lung cancer.MPLC is mainly diagnosed based on the pathological type,genetic characteristics,imaging features,appearance and clinical symptoms of the tumor,and adopts multidisciplinary treatment based on surgery.This paper summarizes the latest literature developments on the epidemiological characteristics,etiology,diagnosis,differential diagnosis,treatment and prognosis of MPLC. 2020 Vol. 27 (10): 32-35 [Abstract] ( 84 ) HTML (41 KB)  PDF  (0 KB)  ( 16 ) 36 Research progress on risk factors and nursing countermeasures of pressure ulcers in surgical patients GUO Xiang-ling Surgical pressure ulcers is also called "pressure sore",mainly due to the inability to move the patient′s position during operation,local tissue pressure can not be relieved in time,resulting in blood circulation disorder,tissue hypoxia,ischemia,etc.,and then soft tissue necrosis,festering is extremely common in elderly patients with surgery.Surgical pressure ulcers significantly aggravate the patient′s psychological and physical discomfort,which is manifested as anxiety,worry,fear and severe stress response,which can easily lead to various postoperative complications.Surgical pressure ulcers affect the body′s rehabilitation,reduce the surgical effect,prolong the hospitalization time,increase the cost of hospitalization and the difficulty of nursing,and have now attracted the attention of the clinic.This article focuses on the risk factors of surgical pressure ulcers and nursing measures. 2020 Vol. 27 (10): 36-39 [Abstract] ( 85 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 40 Effect comparison of Amiodarone and Lidocaine in the treatment of severe ventricular arrhythmias LONG Jun-cheng Objective To compare the effect of Amiodarone and Lidocaine in the treatment of severe ventricular arrhythmias.Methods Sixty-two patients with severe ventricular arrhythmias admitted to cardiology department of our hospital from February 2017 to February 2019 were selected as the research subjects,and all patients were divided into the control group(n=31)and the observation group(n=31)according to the random number table method.The control group was treated with Lidocaine,and the observation group was treated with Amiodarone.The clinical efficacy,cardiac function indexes(left ventricular ejection fraction[LVEF],left ventricular end-diastolic diameter[LVEDD],left ventricular end-systolic diameter[LVESD])before and after treatment and incidence of adverse reactions of patients were observed between the observation group and the control group.Results The total effective rate of treatment in the observation group was 96.77%,which was higher than 67.74% in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in cardiac function indexes between the two groups before treatment(P＞0.05).After treatment,the LVEF,LVEDD,and LVESD of the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).The LVEF,LVEDD,and LVESD of the observation group after treatment were lower than those of the control group,and the differences were statistically significant(P＜0.05).The total incidence rate of adverse reactions in the observation group was 9.68%,which was lower than 35.48%in the control group,and the difference was statistically significant(P＜0.05).Conclusion Amiodarone has a good clinical efficacy on severe ventricular arrhythmia,it can effectively improve the cardiac function of patients,and has a higher safety and significant effect,which is worthy of extensive promotion in clinical practice. 2020 Vol. 27 (10): 40-42 [Abstract] ( 89 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 43 Clinical effect of Atorvastatin combined with Aspirin in the treatment of coronary heart disease WANG Qi Objective To discuss the effect of Atorvastatin combined with Aspirin in the treatment of coronary heart disease.Methods A total of 110 patients with coronary heart disease treated in our hospital from January 2018 to January 2019 were selected as the study subjects.According to the average classification method,they were divided into the control group and the observation group,with 55 cases in each group.The control group was treated with Aspirin.The observation group was treated with Atorvastatin in combination with Aspirin.The treatment effect,blood lipid levels,duration of angina pectoris,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The levels of triglyceride,serum total cholesterol and low-density lipoprotein cholesterol in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The highdensity lipoprotein cholesterol of the observation group was higher than that of the control group after treatment,and the difference was statistically significant(P＜0.05).The duration of angina pectoris in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Atorvastatin combined with Aspirin in the treatment of coronary heart disease can improve the clinical effect of patients with coronary heart disease,which is worthy of popularization and application. 2020 Vol. 27 (10): 43-45 [Abstract] ( 88 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 46 Clinical effect of Levosimendan in the treatment of chronic heart failure in the elderly ZHANG Wei-hua; QIU Wei-lin; LI Zhi-long  Objective To explore the clinical effect of Levosimendan in the treatment of chronic heart failure(CHF)in the elderly.Methods Seventy-two elderly patients with CHF treated in our hospital from February 2017 to February 2019 were selected as the research subjects.The patients were divided into the conventional group and the Levosimendan group according to the random number table method,with 36 patients in each group.In the conventional group,regular treatment was used,and in the Levosimendan group,regular treatment combined with Levosimendan was adopted.The serological indicators,cardiac structure,and clinical treatment effect of the two groups were analyzed.Results After 12 and 24 weeks of treatment,the heart fatty acid binding protein(H-FABP),cardiac troponin I(cTnI),aminoterminal brain natriuretic peptide precursor(NT-proBNP),and endothelium-1(ET-1),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),and serum matrix metalloproteinase-9(MMP-9)in the Levosimendan group were lower than those in the conventional group,and the differences were statistically significant(P＜0.05).The nitric oxide(NO),left ventricular ejection fraction(LVEF)and insulin-like growth factor-1(IGF-1)in the levosimendan group were higher than those in the conventional group,the differences were statistically significant(P＜0.05).The total effectiveness rate of treatment in the levosimendan group was higher than that in the conventional group,the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Levosimendan can improve the clinical efficacy of CHF in the elderly,which has a good application effect. 2020 Vol. 27 (10): 46-49 [Abstract] ( 90 ) HTML (39 KB)  PDF  (0 KB)  ( 10 ) 50 Applicatin effect comparison of different dosage of statins in the early stage of acute myocardial infarction CHENG Qian-kun Objective To compare the application effect of different dosage of statins in the early stage of acute myocardial infarction.Methods A total of 60 patients with early stage of acute myocardial infarction treated in our hospital from October 2017 to January 2019 were selected as the subjects.They were divided into experimental group and control group by random number table method,with 30 cases in each group.Patients in the experimental group were treated with Rosuvastatin 20 mg/d,while patients in the control group were treated with Rosuvastatin 10 mg/d,and the patients in both groups were treated for 6 months.The total effective rate,blood lipid index,C-reactive protein,blood pressure and adverse reactions of the two groups were compared.Results The total effective rate of the experimental group was 96.7%,higher than that of the control group(73.3%),the difference was statistically significant(P＜0.05).The levels of triacylglycerol,total cholesterol,low density lipoprotein and C-reactive protein in the experimental group were lower than those in the control group,and the level of high density lipoprotein was higher than that in the control group,the differences were statistically significant(P＜0.05).The systolic and diastolic blood pressure in the experimental group were lower than those in the control group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion In the early stage of acute myocardial infarction,20 mg/d Rosuvastatin can improve the clinical effect,improve the blood lipid index,C-reactive protein level,reduce the blood pressure,reduce the occurrence of adverse reactions,and have a higher safety.It is worthy of clinical application. 2020 Vol. 27 (10): 50-52转59 [Abstract] ( 84 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 53 Clinical effect of small bone window craniotomy in the treatment of hypertensive cerebral hemorrhage HUANG Hao； LIU Kun； ZHOU Dan Objective To explore the clinical effect of small bone window craniotomy in the treatment of hypertensive cerebral hemorrhage.Methods A total of 82 patients with hypertensive cerebral hemorrhage treated in our hospital from July 2017 to April 2019 were selected as the subjects,and divided into control group(n=41)and experimental group(n=41)by digital parity method.The control group used the traditional operation scheme,and the experimental group used the small bone window craniotomy scheme.The total effective rate,quality of life score,intraoperative blood loss,incision length,operation time and hospitalization time between the two groups were compared.Results The total effective rate of the experimental group(97.56%)was higher than that of the control group(80.49%),with statistical significance(P＜0.05).The scores of cognitive function,physical function,social ability and role function in the experimental group were higher than those in the control group,the differences were statistically significant(P＜0.05).The intraoperative blood loss of the experimental group was less than that of the control group,and the incision length,operation time and hospitalization time of the experimental group were shorter than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Small bone window craniotomy can improve the total effective rate of patients with hypertensive cerebral hemorrhage,improve the patients′ quality of life and operation related indicators,and promote the recovery and early outcome of patients′ living ability.It is worthy of clinical application. 2020 Vol. 27 (10): 53-55 [Abstract] ( 88 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 56 Study on correlation between basilar artery plaque parameters and infarct volume LU Xin； YANG Yin-dong； YANG Xiao-fan； CHEN Lan-juan； XIE Jin-jin； HOU Zong-yi Objective To measure the infarct volume and basilar artery plaque parameters in patients with brainstem infarction by resolution magnetic resonance imaging of vascular walls,and to determine the relationship between plaque parameters and infarct volume.Methods A total of 22 patients with brainstem infarction initially diagnosed in Hongqi Hospital Affiliated to Mudanjiang Medical University from October 2017 to June 2018 were enrolled for high-resolution magnetic resonance imaging.The infarct volume,lumen area at the narrowest level,vascular area at the narrowest level,maximum wall thickness and minimum wall thickness were measured by software.The wall area,narrowest patch area,stenosis rate,reconstruction index,patch load and eccentricity index were calculated.The correlation between plaque parameters and infarct volume was analyzed.Results The infarction volume of the 22 patients included in the analysis was(309.07±253.97)mm3,the lumen area at the narrowest level was(4.54±4.13)mm2,the vascular area at the narrowest level was(15.60±8.04)mm2,the wall area was(11.09±4.89)mm2,the plaque area at the narrowest level was(3.63±2.81)mm2,the maximum wall thickness was(1.30±0.32)mm,the minimum wall thickness was(0.60±0.22)mm,and the stenosis rate was 3%～88%.The results of reconstruction mode showed that 7 cases were positive reconstruction,9 cases were negative reconstruction,and 6 cases showed no obvious reconstruction.Negative reconstruction was as common as positive reconstruction.Pearson correlation analysis results showed that the infarct volume was positively correlated with the stenosis rate(r=0.45,P=0.04)and negatively correlated with the reconstruction index(r=-0.47,P=0.03).Conclusion 3.0 T high resolution magnetic resonance measurement of basilar artery plaque parameters can be used to guide clinical treatment and disease monitoring,which is conducive to improving long-term prognosis. 2020 Vol. 27 (10): 56-59 [Abstract] ( 82 ) HTML (41 KB)  PDF  (0 KB)  ( 7 ) 60 Clinical effect of Quintiapine in the treatment of sleep disorder in depression ZHU Fu-lai； SUN Bin； LI Ya-kun Objective To study the clinical effect of Quintiapine in the treatment of sleep disorder in depression.Methods A total of 99 inpatients with depression complicated with sleep disorder treated in the Third People′s Hospital of Ji′an City from January 2017 to January 2019 were selected as the subjects,and divided into experimental group(33 cases,treated with Quintiapine)and control group 1(33 cases,treated with Eszopiclone)and control group 2(33 cases,treated with Alprazolam).The depression(Hamilton depression scale),sleep quality improvement(Pittsburgh sleep quality index scale),adverse reactions(drug side effects scale)and clinical treatment effect among the three groups were compared before and after treatment.Results There was no significant difference in the scores of depression,sleep quality and adverse reactions among the three groups before treatment(P＞0.05).After treatment,the scores of depression and sleep quality in the experimental group were lower than those in the control group 1 and control group 2,the differences were statistically significant(P＜0.05).There was no significant difference in the scores of adverse reactions among the three groups(P＞0.05).The total effective rate of clinical treatment in the experimental group was higher than that in the control group 1 and control group 2,the difference was statistically significant(P＜0.05).Conclusion Quintiapine is effective in the treatment of depressive sleep disorders,and can actively improve sleep quality and depression. 2020 Vol. 27 (10): 60-62转70 [Abstract] ( 126 ) HTML (34 KB)  PDF  (0 KB)  ( 15 ) 63 Effect of safe swallowing management based on swallowing function classification in elderly patients with Alzheimer′s disease eating difficulties WU Hui-min； ZOU Xi-hong； GAO Jing-bin Objective To study the effect of safe swallowing management based on swallowing function classification in elderly patients with Alzheimer′s disease eating difficulties.Methods From May 2016 to July 2018,60 elderly patients with Alzheimer′s disease eating difficulties treated in our hospital were selected as the study objects.The patients were divided into experimental group(28 cases)and control group(32 cases)by simple randomization method.Patients in the control group were given routine diet nursing.Patients in the experimental group were given safe swallowing management,and the patients were evaluated according to the Teng′s swallowing disorder evaluation method and given corresponding safe swallowing management measures.The diet effects,nutritional status and eating cough of two groups before and after intervention were compared.Results After intervention,the time of eating per meal in the experimental group was shorter than that in the control group,and the amount of eating per meal and drinking water per meal in the experimental group were more than those in the control group,the differences were statistically significant(P＜0.05).The levels of serum prealbumin,albumin and hemoglobin in the experimental group were higher than those in the control group,and the level of triacylglycerol was lower than that in the control group,the differences were statistically significant(P＜0.05).The incidence of eating and coughing in the experimental group(10.71%)was lower than that in the control group(31.25%),the difference was statistically significant(P＜0.05).Conclusion The application of safe swallowing management based on swallowing function grading in elderly patients with Alzheimer′s disease who have difficulty eating has better effect.It can not only promote patients′ food intake,improve the nutritional status of patients,but also reduce the incidence of eating and choking cough. 2020 Vol. 27 (10): 63-66 [Abstract] ( 99 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 67 Effect of early swallowing rehabilitation training on patients with dysphagia in acute cerebral infarction CHEN Xiang Objective To observe the effect of early rehabilitation of swallowing function on improving nutritional status and ability of daily living(ADL)in patients with dysphagia in acute cerebral infarction(ACI).Methods Eighty-four patients with dysphagia in ACI from February 2018 to June 2019 treated in our hospital were selected as the subjects,and divided into observation group and control group by random number table method,with 42 cases in each group.In the control group,a conventional treatment plan was carried out,and in the observation group,early rehabilitation training for swallowing function on the basis of the control group was added.The courses of treatment lasted 4 weeks.The swallowing function,nutritional status,and ADL scores of the two groups were evaluated before and after the intervention.Results The swallowing function of the patients in the observation group after intervention was better than that before intervention,and better than that in the control group,the differences were statistically significant(P＜0.05).After intervention,the levels of total protein(TP),albumin(ALB),and triglyceride(TG)in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The ADL scores of the two groups after intervention were higher than those before intervention,and the ADL score of the observation group after intervention was higher than that of the control group,the differences were statistically significant(P＜0.05).Conclusion The combination of early swallowing function rehabilitation exercise in conventional treatment programs can effectively promote the recovery of swallowing function in patients with dysphagia in ACI,increase the ADL score,and improve the nutritional status of patients to a certain extent,which is beneficial to the recovery of the disease. 2020 Vol. 27 (10): 67-70 [Abstract] ( 99 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 71 Changes and significance of serum homocysteine levels in patients with early cerebral infarction XU Kun-ming； LI Shui-bin； CAO Yu-min； LAI Shu-fan Objective To investigate the changes and significance of serum homocysteine levels in patients with early cerebral infarction.Methods A total of 50 patients with early cerebral infarction admitted to our hospital from January to June 2019 were enrolled in the observation group.50 patients with non-cerebral infarction in our hospital were selected as the control group.The level of cystine(Hcy)was determined.According to the condition of patients with cerebral infarction,they were divided into mild,moderate and severe groups.The Hcy levels of the three groups were compared,and the neurological deficits of the three groups were evaluated.The relationship between Hcy and neurological deficits were analysed.Results The Hcy and neurological deficit scores of patients in the severe and moderate groups were higher than those in the mild group,the difference was statistically significant(P＜0.05).The Hcy and neurological deficit scores in the severe group were higher than those in the moderate group,the differences were statistically significant(P＜0.05);and the Hcy level in patients with cerebral infarction was positively correlated with the clinical neurological deficit score(r=0.81,P＜0.05).Conclusion Serum homocysteine can play a positive reference value for early diagnosis of cerebral infarction,assessment of disease severity and prognosis,and it has a greater correlation with neurological deficit. 2020 Vol. 27 (10): 71-73 [Abstract] ( 105 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 74 Application effect of Gastrodin Injection combined with Diphenhydramine Hydrochloride Injection in patients with acute vertigo PAN Yong-yao Objective To explore the effect of Gastrodin Injection combined with Diphenhydramine Hydrochloride Injection in patients with acute vertigo.Methods A total of 74 patients with acute vertigo admitted to the emergency department of our hospital from June 2018 to June 2019 were selected.According to the sequence of treatment time,patients were divided into observation group(n=37)and control group(n=37).The control group was treated with Diphenhydramine Hydrochloride Injection,while the observation group was treated with Gastrodin Injection combined with Diphenhydramine Hydrochloride Injection.The clinical efficacy,vertigo score before and after treatment,time of vertigo improvement and incidence of adverse reactions were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment for 1 and 2 days,the vertigo scores of the observation group were higher than those of the control group,the differences were statistically significant(P＜0.05).The time of vertigo improvement in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Gastrodin Injection combined with Diphenhydramine Hydrochloride Injection has a significant effect in the treatment of acute vertigo,which can effectively improve the vertigo of patients.It is worthy of clinical application. 2020 Vol. 27 (10): 74-76 [Abstract] ( 96 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 77 Application of radical cystectomy combined with ileal orthotopic neobladder in patients with bladder cancer YU Zu-hui； CHEN Bing-chen； WU Xiao-wen； HUANG Qi-ming； LIN Zhen-ming Objective To study the application effect of radical cystectomy combined with ileal orthotopic neobladder in patients with bladder cancer.Methods A total of 80 cases of bladder cancer patients treated in our hospital from July 2017 to May 2018 were selected as the research subjects.The patients were divided into an experimental group(n=40)and a control group(n=40)according to the random number table method.Patients in the control group received radical cystectomy combined with sigmoid orthotopic neobladder,and patients in the experimental group received radical cystectomy combined with ileal orthotopic neobladder.The results of urinary dynamic examination 2 and 4 months after operation the results of urodynamic examination during bladder filling as well as the bladder function were compared between the two groups.Results The maximum abdominal pressure,maximum detrusor pressure,and maximum bladder pressure during the urination period in the experimental group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The bladder compliance during the filling period was higher than that of the control group.The bladder pressure and internal pressure of the bladder filling were lower than those of the control group,and the differences were statistically significant(P ＜0.05).There were no significant differences in neobladder capacity,residual urine and maximum urine flow rate between the two groups(P＞0.05).Conclusion Compared with the sigmoid orthotopic neobladder,the ileal orthotopic neobladder has many more advantages after radical cystectomy.It can effectively promote postoperative bladder compliance,increase the maximum detrusor muscle pressure,and the rate of day and night urine control. 2020 Vol. 27 (10): 77-79 [Abstract] ( 99 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 80 Clinical effect of percutaneous nephrolithotomy laser lithotripsy under Xray localization in the treatment of ureteral calculi HUANG Jun-cheng； LING Feng； MO Fang-sheng； CHEN Hao-xian； CHEN Hong-ming Objective To investigate the clinical effect of percutaneous nephrolithotomy laser lithotripsy under X-ray localization in the treatment of ureteral calculi.Methods A total of 210 patients with ureteral calculi treated in our hospital from January 2012 to January 2019 were enrolled.The patients were divided into open group(n=105)and lithotripsy group(n=105)according to computer random sampling grouping method.The open group was treated with open surgical stone removal,and the lithotripsy group was treated with percutaneous nephrolithotomy laser lithotripsy under X-ray localization.The stone removal effect,surgical and postoperative recovery status,complications and quality of life of were compared between the two groups.Results There was no significant difference in the complete clearance rate of stones at 1 month after operation(P＞0.05).The intraoperative blood loss of the lithotripsy group was less than that of the open group.The operation time and postoperative hospital stay in the lithotripsy group were shorter than those in the open group.The total incidence of postoperative complications in the lithotripsy group was lower than that in the open group.The quality of life score was higher than that of the open group at 2 weeks after operation,and the differences were statistically significant(P ＜0.05).Conclusion The treatment of ureteral calculi with percutaneous nephrolithotomy laser lithotripsy under X-ray localization can achieve good stone removal,with less trauma,less complications and quick recovery,which can improve the prognosis. 2020 Vol. 27 (10): 80-82转86 [Abstract] ( 94 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 83 Clinical effect of Dapagliflozin in the treatment of newly diagnosed type 2 diabetes mellitus TIAN Rui Objective To investigate the clinical effect and safety of Dapagliflozin in the treatment of newly diagnosed type 2 diabetes mellitus.Methods A total of 70 newly diagnosed type 2 diabetes mellitus patients treated in our hospital from March 2018 to June 2019 were selected as the research subjects.The patients were divided into observation group(36 cases)and control group(34 cases)according to the randomized control principle.The patients in the observation group were treated with Dapagliflozin alone,while those in the control group were treated with Metformin alone.The blood glucose indexes(fasting blood glucose[FBG],post-prandial glucosese[PBG],glycosylated hemoglobin[HbA1c])levels,body mass index(BMI),blood pressure(systolic blood pressure[SBP],diastolic blood pressure[DBP]),lipid indicators(total cholesterol[TC],triacylglycerol[TG]),liver and kidney function indicators(alanine aminotransferase[AST],aspartate aminotransferase[ALT],creatinine[Cr])levels before and after treatment and the total incidence rate of adverse reactions were compared between the two groups of patients.Results After 12 weeks of treatment,the FBG,PBG,HbA1c,and BMI of the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).There were no significant differences in FBG,PBG,HbA1c,and BMI between the two groups after 12 weeks of treatment(P＞0.05).After 12 weeks of treatment,the SBP,TC,and TG in the observation group were lower than those before treatment,and the differences were statistically significant(P＜0.05).The SBP in the observation group was lower than that in the control group after 12 weeks of treatment,and the difference was statistically significant(P＜0.05).There was no significant hypoglycemia or allergic reaction in both groups.The total incidence rate of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Dapagliflozin has a definite hypoglycemic effect in the treatment of newly diagnosed type 2 diabetes mellitus,and it can also improve a number of metabolic indicators,without obvious gastrointestinal reactions,and with high safety. 2020 Vol. 27 (10): 83-86 [Abstract] ( 107 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 87 Application of perioperative iodine-free administration in patients with hyperthyroidism XU Zhi-hui； HU Huan Objective To explore the application effect of perioperative iodine-free administration in patients with hyperthyroidism.Methods A total of 78 patients with hyperthyroidism who were treated in our hospital from October 2014 to December 2017 were selected as the research subjects.They were divided into the control group(n=39)and the observation group(n=39)according to the random number table method.In the control group,oral administration of iodine during perioperative period was used,and in the observation group,perioperative iodine-free was adopted.The related surgical indicators,serum free triiodothyronine(FT3)and serum free thyroxine(FT4)levels before and after treatment,incidence of complications after treatment was compared between the two groups.Results There were no significant differences in intraoperative blood loss or operation time between the two groups(P＞0.05).The hospital stay in the observation group after treatment was shorter than that in the control group,and the difference was statistically significant(P＜0.05).There were no significant differences in FT3 or FT4 level between the two groups after treatment(P＞0.05).After treatment,the symptoms of hoarseness,temporary parathyroid injury,and hypothyroidism in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in the levels of thyroid peroxidase antibody(TPOAb)or thyroglobulin antibody(TGAb)before treatment in the two groups(P＞0.05).After treatment,the TPOAb and TGAb indicators in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Perioperative iodine-free administration in patients with hyperthyroidism is feasible,and its routine indicators have not changed significantly,and complications have been reduced,which is worthy of promotion and application. 2020 Vol. 27 (10): 87-89转93 [Abstract] ( 100 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 90 Effect of Insulin Glargine combined with Metformin on islet function and inflammatory factor levels in patients with type 2 diabetes mellitus YANG Yan-yan； LI Fei Objective To investigate the effect of Insulin Glargine combined with Metformin on islet function and inflammatory factor levels in patients with type 2 diabetes mellitus.Methods From June 2018 to May 2019,102 patients with type 2 diabetes mellitus were selected as research subjects,and they were divided into experimental group(n=51)and reference group(n=51)according to the random number table method.In the experimental group,Insulin Glargine+ Metformin was used,and in the reference group,Protamine Biosynthetic Human Insulin + Glargine Insulin was used.The islet function,inflammatory factor levels,and blood glucose levels of the two groups before and after treatment were compared.Results There were no significant differences in the C-peptide,postprandial C-peptide,hyper-sensitivity C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),fasting blood glucose,2 h postprandial blood glucose,and glycated hemoglobin between the two groups before treatment(P＞0.05).The C-peptide and post-prandial C-peptide in the experimental group were higher than those in the reference group after treatment,and the differences were statistically significant(P＜0.05).In the experimental group,the levels of hs-CRP,TNF-α,fasting blood glucose,2 h postprandial blood glucose,and glycated hemoglobin were lower than those in the reference group after treatment,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions was lower than that of the reference group,and the difference was statistically significant(P＜0.05).Conclusion Patients with type 2 diabetes mellitus receiving the treatment of Insulin Glargine + Metformin obtain marked effects.Meanwhile,this regimen can improve patients′ islet function,inflammatory factor levels,and blood glucose levels.It is applicable to the treatment and promotion of patients with type 2 diabetes mellitus. 2020 Vol. 27 (10): 90-93 [Abstract] ( 77 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 94 Clinical effect of anastomotic sacral circumcision combined with ultrasonic scalpel in the treatment of severe mixed hemorrhoids LIU Ke-wen； ZHOU Hao； WANG Gui-ming Objective To study the clinical effect of stapler hemorrhoidectomy(PPH)combined with ultrasound scalpel in the treatment of severe mixed hemorrhoids.Methods Sixty patients with severe mixed hemorrhoids admitted to our hospital from June 20 to May 2019 were selected as the subjects.They were divided into group A,group B and group C by strokes,with 20 cases in each group.Group A was treated with PPH combined with ultrasonic scalpel,group B was treated with PPH combined with electrocautery,and group C was treated with PPH combined with conventional resection.The operation time,intraoperative blood loss,wound healing time,24 h postoperative pain score and complications such as postoperative secondary hemorrhage,anal edema and anal stenosis were compared.Results The operation time and wound healing time in group A were shorter than those in group B and C,the intraoperative blood loss was less than that in group B and C,the operation time and wound healing time in group B were shorter than those in group C,the intraoperative blood loss was less than that in group C,and the differences were statistically significant(P＜0.05).The 24 h pain score of group A was lower than that of group B and group C,and the differences were statistically significant(P＜0.05).The total incidence of complications in group A was lower than that in group B and C,and the difference was statistically significant(P＜0.05).Conclusion PPH combined with ultrasound scalpel has a significant clinical effect in the treatment of severe mixed hemorrhoids,which can effectively control the risk of complications and intraoperative bleeding,reduce the impact of surgical operation on the health of the body,and has a high clinical popularization value. 2020 Vol. 27 (10): 94-96 [Abstract] ( 71 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 97 Clinical effect of external hemorrhoidectomy combined with elastic line internal hemorrhoid ligation in the treatment of mixed hemorrhoids of grade Ⅲand Ⅳ WU Wei-guo； WU Xue-qing； WANG Zhi-liang Objective To investigate the clinical effect of external hemorrhoidectomy combined with elastic line internal hemorrhoid ligation in the treatment of mixed sputum of grade Ⅲand Ⅳ.Methods Seventy patients with mixed sputum of grade Ⅲand Ⅳwho were admitted to Fuzhou Hospital of Traditional Chinese Medicine from January to December 2018 were selected as subjects.They were divided into observation group(n=35)and control group(n=35)by computer blind selection method.The control group was treated with mixed external hemorrhoids and internal ligation.The observation group was treated with external hemorrhoidectomy and elastic line internal hemorrhoid ligation.The operation time,intraoperative blood loss,hospitalization time,symptom score,recurrence rate,total complication rate and total treatment efficiency of the two groups were compared.Results The operation time,hospitalization time and wound healing time of the observation group were shorter than those of the control group,and the differences were statistically significant(P＜0.05).The intraoperative blood loss in the observation group was less than that in the control group,the total effective rate was higher than that of the control group,and the differences were statistically significant(P＜0.05).Before treatment,the symptomscores of pain,edema and blood in the stool in the two groups showed no significant differences(P＞0.05).After treatment,the symptom scores of pain,edema and blood in the stool in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).The total incidence of complications and recurrence rate in the observation group were not significantly different from those in the control group(P＞0.05).Conclusion The treatment of mixed hemorrhoids of grade Ⅲand Ⅳwith external hemorrhoidectomy and elastic line internal hemorrhoid ligation can significantly improve or eliminate various clinical conditions,improve the efficiency of surgical treatment,and the effect is stable.It is worthy of clinical application. 2020 Vol. 27 (10): 97-100 [Abstract] ( 75 ) HTML (37 KB)  PDF  (0 KB)  ( 14 ) 101 Effect of Gukangfang Granules in the treatment of senile osteoporosis CUI Bang-sheng； CHEN Mian-zhi； WU Jia-jun； LIU Yan-fen Objective To explore the effect of Gukangfang Granules in the treatment of senile osteoporosis.Methods A total of 60 cases of senile osteoporosis patients admitted to Shunde Hospital of Guangzhou University of Chinese Medicine from April 2016 to March 2019 were selected as the research objects.According to the random number table method,they were divided into the observation group(30 cases)and the control group(30 cases).The observation group took Calcium Tablets+Alfacalcohol+Alendronate Sodium Tablets+Gukangfang Granules,the control group took Calcium Tablets+Alfacalcohol+Alendronate Sodium Tablets,and both groups were treated for 3 months.The improvement of pain and the occurrence of adverse reactions in the two groups of patients were observed,and the bone mineral density before and after treatment was compared in the two groups.Results The total effective rate of pain improvement in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in bone mineral density before treatment between the two groups of patients(P＞0.05).The bone mineral density of the two groups of patients after 3 months of treatment was higher than that before treatment,and the difference was statistically significant(P＜0.05).The bone mineral density in the observation group of patients after 3 months of treatment was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were no serious adverse reactions during the treatment in the two groups.Conclusion Gukangfang Granules can better relieve the symptoms of pain,and effectively increase the bone mineral density of patients,and can be promoted and used in clinic. 2020 Vol. 27 (10): 101-104 [Abstract] ( 80 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 105 Comparison of the clinical effect of spinal fusion with unilateral and bilateral pedicle screw fixation in spinal degenerative diseases CHEN Tian-he; CHEN Xiao-hu; GUO Qiang; YANG Zhong-han Objective To investigate the effect of spinal fusion with unilateral and bilateral pedicle screw fixation in spinal degenerative diseases.Methods From June 2017 to March 2019,40 patients who met the diagnostic criteria of spinal degenerative diseases were selected as the subjects of the study,they were randomly divided into group A(20 cases)and group B(20 cases)by the random digital table method.Group A was treated with unilateral pedicle screw,and group B was treated with bilateral pedicle screw.The length of operation,the amount of bleeding,the length of hospitalization and postoperative complications were compared between the two groups.The changes of visual analogue scale(VAS)score of waist and leg visual analog score and the changes of Oswestry disability index(ODI)score of the two groups were observed.Results The operation time and hospitalization time of group A were shorter than those of group B,and the amount of bleeding of group A was less than that of group B,the differences were statistically significant(P＜0.05).There was no significant difference in postoperative fusion rate between the two groups(P＞0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(P＞0.05).In addition,after surgical treatment,the VAS score and ODI score of waist and leg in the two groups were lower than those before operation,the differences were statistically significant(P＜0.05).There was no significant difference in VAS score and ODI score between the two groups after operation(P＞0.05).Conclusion The operative effect of unilateral and bilateral pedicle screw internal fixation spinal fusion is similar in the treatment of spinal degenerative diseases,but unilateral pedicle screw internal fixation has the advantages of short operation time,less bleeding and short hospitalization time,which is worthy of further clinical study and application. 2020 Vol. 27 (10): 105-108 [Abstract] ( 74 ) HTML (38 KB)  PDF  (0 KB)  ( 9 ) 109 Clinical application effect of five-point support postoperative rehabilitation exercise combined with percutaneous kyphoplasty in osteoporotic compression fracture of spine LI Bing-gen; ZHAO Jin-liang Objective To explore the clinical application effect of five-point support postoperative rehabilitation exercise combined with percutaneous kyphoplasty(PKP)in osteoporotic compression fracture of spine.Methods A total of 80 cases with osteoporotic compression fracture of spine admitted to Department of Spinal Surgery in Hunan University of Traditional Chinese Medicine and Hunan Provincial Hospital of Traditional Chinese Medicine from November 2017 to July 2019 were selected as the research object,and they were divided into the control group and the observation group according to random number table method,with 40 cases in each group.The control group was treated with PKP,the observation group was treated with five-point support postoperative rehabilitation exercise on the basis of the control group.After discharge,the patients were followed up for one month in outpatient department.The height of anterior and middle column of the injured vertebral bodies,pain and activity ability of the two groups were compared.The time of 10-meter walking and 5 times of sitting position of the two groups were analyzed,and the clinical treatment effect of the two groups was statistically analyzed.Results The height of the anterior and middle column of the injured vertebral bodies in the observation group at one month after discharge were higher than those in the control group,the differences were statistically significant(P＜0.05).The score of lumbago and back pain in the observation group at one month after discharge was lower than that in the control group,and the score of activity ability in the observation group at one month after discharge was higher than that in the control group,the differences were statistically significant(P＜0.05).The time of 10-meter walking and 5 times of sitting position in the observation group at one month after discharge were shorter than that of control group,the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 95.0%,which was higher than 75.00% of the control group,the difference was statistically significant(P＜0.05).Conclusion For elderly osteoporosis patients with compression fracture of spine after PKP,five-point support to strengthen lumbar and dorsal muscle function exercise can effectively improve the recovery of injured vertebral anatomical structure,relieve pain,improve life exercise ability,and thus improve clinical treatment effect. 2020 Vol. 27 (10): 109-112 [Abstract] ( 72 ) HTML (38 KB)  PDF  (0 KB)  ( 15 ) 113 Effect of hepatitis B virus DNA content on pregnancy outcomes JIA Li-hong; ZHAO Xiao-ling; CAO Dan-dan; WANG Su-mei Objective To study and analyze the effect of hepatitis B virus DNA content on pregnancy outcome.Methods From January 2017 to January 2019,270 parturients with HBV detected in the Department of Obstetrics,Maternal and Child Health Care Family Planning Service Center of Huizhou City were selected as the research objects.The DNA contents of 270 parturients were recorded.According to the level of HBV-DNA content,they were divided into three groups：group A(HBV-DNA＞1×106 copies/m,n=94),group B(5×102 copies/ml≤HBV-DNA≤1×106 copies/ml,n=86)and group C(HBV-DNA＜5×102 copies/ml,n=90).The complications of pregnancy hypertension,gestational diabetes,premature rupture of membranes and postpartum hemorrhage were compared among three groups,and the adverse impact of HBV-DNA content on the parturient were summarized.The incidence rates of premature delivery,neonatal asphyxia,low birth weight and stillbirth were compared among three groups,and the adverse impact of HBV-DNA content on the perinatal was summarized.Results The incidence rates of complications such as gestational hypertension,gestational diabetes,premature rupture of membranes and postpartum hemorrhage in group A were higher than those in group B and C,and the incidence rates of complications such as gestational hypertension,gestational diabetes,premature rupture of membranes and postpartum hemorrhage in group B were higher than those in group C,the differences were statistically significant(P＜0.05).The incidence rates of premature delivery,neonatal asphyxia and low birth weight in group A were higher than those in group B,the differences were statistically significant(P＜0.05).The incidence rates of premature delivery,neonatal asphyxia and low birth weight in group A were higher than those in group C,the differences were statistically significant(P＜0.05).There were no significant differences in the incidence rates of premature delivery,asphyxia and low birth weight between the two groups(P＞0.05).There were no significant differences in the incidence rates of stillbirth among the three groups(P＞0.05).Conclusion With the increase of hepatitis B virus DNA content,the incidence of complications such as pregnancy hypertension,gestational diabetes,premature rupture of membranes,postpartum hemorrhage and the incidence of premature delivery,neonatal asphyxia,low birth weight of newborn also increase,which will increase the adverse impact on pregnancy. 2020 Vol. 27 (10): 113-116 [Abstract] ( 75 ) HTML (37 KB)  PDF  (0 KB)  ( 14 ) 117 Clinical effect of intrauterine balloon compression hemostasis method in the treatment of postpartum hemorrhage SU Yue-ting; ZHANG Yuan-feng; LIU Yi-xue Objective To investigate the clinical effect of intrauterine balloon compression and hemostasis in the treatment of postpartum hemorrhage.Methods A total of 56 cases of postpartum hemorrhage patients admitted to our hospital from August 2017 to December 2018 were selected as the study subjects.According to the random number table method,they were divided into control group(n=28)and observation group(n=28).The control group was treated with intrauterine gauze to stop bleeding.The observation group was treated with intrauterine balloon compression hemostasis.The intrauterine tamponade treatment time,hemostasis efficiency,uterine artery ligation rate,postoperative complication rate,24 h postpartum bleeding volume,hemostasis time,hemoglobin,time of getting out of bed and staying in hospital after operation between two groups were compared.Results The intrauterine tamponade treatment time of the observation group was shorter than that of the control group,the difference was statistically significant(P＜0.05).The hemostasis efficiency of the observation group was higher than that of the control group,and the uterine artery ligation rate was lower than the control group,the differences were statistically significant(P＜0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The bleeding volume in the observation group was lower than that in the control group at 24 hours postpartum,the hemostasis time was shorter than that of the control group,and the differences were statistically significant(P＜0.05).The hemoglobin level in the observation group was higher than that in the control group,and the time of hospitalization and hospitalization were shorter than those of the control group,the differences were statistically significant(P＜0.05).Conclusion The effect of intrauterine balloon compression hemostasis in the treatment of postpartum hemorrhage is significant,which can shorten the operation time,improve the hemostatic efficiency,and the complication rate is lower,which is worth clinical application. 2020 Vol. 27 (10): 117-119 [Abstract] ( 92 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 120 Application effect and safety evaluation of cervical balloon combined with Oxytocin in induction of labor in mid-term pregnancy of scar uterus CHEN Hai-ju Objective To investigate the application effect and safety of cervical balloon combined with Oxytocin in the induction of labor in the mid-term pregnancy of scar uterus.Methods A total of 100 cases of mid-term pregnancy induced by scar uterus in our hospital from January 2016 to September 2019 were selected as the study subjects.According to the random number table method,they were divided into group A(50 cases)and group B(50 cases).The group A was treated with cervical balloon combined with Oxytocin,and group B was treated with oral Mifepristone and Misoprostol.The induction time,induction success rate,placental membrane residual rate,postpartum hemorrhage,and adverse reactions were compared between the two groups.Results The induction time of group A was shorter than that of group B.The success rate of induction of labor in group A was higher than that in group B.The residual rate of placental membrane in group A was lower than that in group B.The amount of postpartum hemorrhage in group A was lower than that in group B.The differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.(P＞0.05).Conclusion Cervical balloon combined with Oxytocin has a certain application effect in the induction of labor in the mid-pregnancy of scar uterus.It is safe and effective and worthy of further clinical application and promotion. 2020 Vol. 27 (10): 120-122转126 [Abstract] ( 74 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 123 Application effect of ultrasonic scalpel hemostasis in the operation of ovarian cyst LIU Jian； HU Hong-bo； LIAO Zong-min Objective To investigate the application effect of ultrasonic scalpel hemostasis in the operation of ovarian cyst.Methods From January 2016 to March 2017,200 patients with ovarian cysts who underwent laparoscopic ovarian cyst removal surgery were selected and divided into the experimental group and the control group according to random number table method,100 cases in each group.In the experimental group,ultrasonic scalpel was used for hemostasis and control group unipolar electrocoagulation was used to hemostasis.Serum estrogen(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),progesterone(P),testosterone(T),ovarian artery peak blood flow velocity(PSV),ovarian cross-sectional area,antral follicle number(AFC)were compared between the two groups before and 1 month after operation.Results Before surgery,there were no significant differences in the number of ovarian artery PSV ovarian cross-sectional area sinus follicles in serum E2,FSH,LH,P,T level between the two groups(P＞0.05).One month after surgery,the levels of serum FSH,PLH,P and E2 in the experimental group were lower than those of the control group,and T level was higher than that of the control group,with statistical differences(P＜0.05).The PSV,AFC in the experimental group were higher than those of the control groups,ovarian cross-sectional area was lower than that of the control group,with statistical differences(P＜0.05).Conclusion In the ovarian cyst surgery,the use of ultrasonic scalpel to hemostasis compared with electrocoagulation to hemostasis has a smaller effect on the ovarian function of the patient,and is more conducive to protecting the patient′s ovarian function. 2020 Vol. 27 (10): 123-126 [Abstract] ( 80 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 127 Clinical effect of single hole laparoscopic high ligature of sheath process in the treatment of hydrocele in children ZHANG Jia-de； HU Xiao-hua； ZHONG Chen； ZHANG Ping-feng Objective To investigate the clinical effect of single hole laparoscopic high ligature of sheath process in the treatment of hydrocele in children.Methods A total of 900 children with hydrocele treated in our hospital from April 2015 to April 2018 were selected and divided into control group and observation group according to random digital table method,450 cases in each group.The control group was treated with traditional high ligature of sheath process.The observation group was treated with single hole laparoscopic high ligature of sheath process.The surgical indexes and complications were compared between two groups.Results The operation was smooth in both groups,and the success rate was 100%,the difference had no statistical significance(P＞0.05).There were no significant differences in operation time and intraoperative blood loss between the two groups(P＞0.05).The recovery time of gastrointestinal function and hospitalization time in the observation group were shorter than those in the control group,and the postoperative visual analogue scale(VAS)was lower than that in the control group,the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The effect of single-hole laparoscopy in the treatment of children′s sheath effusion is accurate,the trauma is small,the postoperative recovery is rapid,the complication rate is low,and it has high effectiveness and safety. 2020 Vol. 27 (10): 127-129 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 130 Clinical effect of ultrasound-guided radiofrequency ablation combined with Mifepristone in the treatment of adenomyosis XUE Jie-tao; CHEN Yan; XIAN Xiao-yan; WANG Chu; LIN Tai-mei Objective To investigate the clinical effect of ultrasound-guided radiofrequency ablation（RFA）combined with Mifepristone in the treatment of adenomyosis.Methods One hundred patients with adenomyosis admitted to our hospital from January 2018 to May 2019 were enrolled in the study.According to the random number table method,they were divided into surgical non-drug treatment group and surgical combined drug treatment group,50 cases in each group.The surgical non-medication treatment group in the operation did not use drug therapy after RFA of adenomyosis.The surgery combined drug treatment group was treated with RFA of adenomyosis and treated with Mifepristone.The therapeutic effects,the amount of menstruation before and after treatment,the volume of uterus before and after treatment,and the incidence of complications were compared between the two groups.Results The total effective rate of surgery combined drug treatment was higher than that of surgical non-medical treatment group,with statistical difference(P＜0.05).Before treatment,there was no significant difference in uterine volume between the two groups(P＞0.05).After treatment,the uterine volume of the two groups was smaller than that before the treatment.The uterus volume of the surgical combined drug treatment group was smaller than that of the non-medical treatment group,and the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference in the amount of menstrual blood between the two groups(P＞0.05).After treatment,the menstrual volume of both groups was less than that before treatment,and the amount of surgery combined drug treatment group was less than that of surgical nonmedical treatment group,the differences were statistically significant(P＜0.05).The complication rate was 2%(1/50)in the surgical combination treatment group lower than 18%(9/50)in the surgical non-medical treatment group.The difference was statistically significant(P＜0.05).Conclusion Adenomyosis with RFA combined with Mifepristone is effective,and can achieve ideal results,reduce menstrual flow and reduce uterine volume,reduce the complications. 2020 Vol. 27 (10): 130-132 [Abstract] ( 79 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 133 Clinical effect of Pediatric Compound Amino Acid Injection combined with Racecadotril Granules on children with rotavirus enteritis WU Yuan-fang; HUANG Hui-yi; YU Shu-juan Objective To study the clinical effect of Pediatric Compound Amino Acid Injection(18AA-Ⅱ)combined with Racecadotril Granules on children with rotavirus enteritis.Methods A total of 150 children with rotavirus enteritis treated in our hospital from March 2017 to January 2018 were selected as study subjects.They were divided into test group(n=75)and control group(n=75)by random number table method.The children in the control group were treated with conventional anti-inflammatory and antiviral and fluid replacement.The test group was treated with 18AA-Ⅱwith Racecadotril Granules on the basis of conventional treatment.The clinical effect,clinical symptom improvement time and serum C-reactive protein(CRP)levels at different periods of the two groups were compared.Results After treatment,the total clinical effective rate of patients in the test group was 90.67%,higher than that of the control group accounting for 76.00%,the difference was statistically significant(P＜0.05).The corrected dehydration time,antidiarrheal time,antipyretic time and vomiting stopping time in the test group were shorter than those in the control group,the differences were statistically significant(P＜0.05).CRP levels of the children in the test group at 24,48,and 72 h after treatments were lower than those in the control group,the difference was statistically significant(P＜0.05).Conclusion The 18AA-Ⅱcombined with Racecadotril Granules in children with rotavirus enteritis has a good clinical effect,which can effectively shorten the symptom relief time and enhance the anti-inflammatory effect. 2020 Vol. 27 (10): 133-135 [Abstract] ( 79 ) HTML (31 KB)  PDF  (0 KB)  ( 13 ) 136 Clinical effect of Clostridium Butyricum Enterococcus Triple Viable Tablets combined with Xiyanping Injection in the treatment of children with pneumonia secondary diarrhea LAI Zhi-fei Objective To explore the clinical effect of Clostridium Butyricum Enterococcus Triple Viable Tablets combined with Xiyanping Injection in the treatment of children with pneumonia secondary diarrhea.Methods Fifty children with pneumonia secondary diarrhea treated in our hospital from January 2017 to January 2019 were selected and divided into control group and study group according to random number table method,25 cases in each group.The control group was given Xiyanping Injection,while the study group was given Clostridium Butyricum Enterococcus Triple Viable Tablets based on the treatment of the control group.The improvement time of symptoms,hospitalization time,effective rate of clinical treatment and the levels of glucagon before meal(Glu),motilin(MTL)and vasoactive intestinal peptide(VIP)were compared between two groups.Results The antipyretic time,antidiarrheal time and dehydration correction time in the study group were shorter than those in the control group(P＜0.05),and the hospitalization time in the study group was shorter than that in the control group(P＜0.05).The levels of Glm,MTL and VIP in both groups were lower than those before treatment,and the levels of Glu、MTL and VIP in the study group were lower than those in the control group(P＜0.05).The effect of study group was better than that of control group(U=2.02,P＜0.05),but there was no significant difference in the total effective rate between the two groups(χ2=3.39,P＞0.05).Conclusion Clostridium Butyricum Enterococcus Triple Viable Tablets combined with Xiyanping Injection can attenuate clinical symptoms,shorten treatment time and improve treatment efficiency,which is worthy of clinical application. 2020 Vol. 27 (10): 136-138 [Abstract] ( 88 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 139 Effect of laparoscopic hysteromyomectomy on endocrine and sexual function of patients with hysteromyoma DENG Xin; PAN Xiao-meng Objective To investigate the effect of laparoscopic myomectomy on endocrine and sexual function in patients with uterine fibroids.Methods A total of 80 patients with uterine enlargement over 10 gestational weeks who were needed hystero myomectomy from January 2017 to June 2018 were selected and divided into control group and observation group according to random number table method,40 cases in each group.Conventional laparotomy was performed in the control group,and laparoscopic hysteromyomectomy was performed in the observation group.Then the recurrence of hysteromyoma and natural pregnancy rate,sexual function and sex hormone levels in the two groups one year after operation were compared.Results The natural pregnancy rate 1 year after operation was higher than that in the control group(P＜0.05).1 year after operation,the sub-item scores and total scores of female sexual quality of life standard scale(FSFI)in the observation group were higher than those in the control group(P＜0.05).On the second day of menstruation one year after operation,the level of serum estradiol(E2)in the observation group was higher than control group,and the level of follicle stimulating hormone(FSH)was lower than control group,the differences were statistically significant(P＜0.05).Conclusion Laparoscopic myomectomy for hysteromyoma can effectively promote postoperative pregnancy,improve sexual function and promote the recovery of sex hormone levels. 2020 Vol. 27 (10): 139-141 [Abstract] ( 77 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 142 Effect of Bifidobacterium Triple Viable Bacteria combined with warm saline enema in thetreatment of feeding intolerance in premature infants SUN Xiu-ying; FU Cong Objective To investigate the effect of Bifidobacteria Triple Viable Bacteria combined with warm saline enema in thetreatment of feeding intolerance of premature infants.Methods A total of 84 cases of premature infants with feeding intolerance admitted to our hospital from August 2018 to August 2019 were selected as study subjects,and were divided into observation group(42 cases)and control group(42 cases)according to the random number table.The control group was treated with Bifidobacteria Triple Viable Bacteria method,while the observation group was treated with Bifidobacteria Triple Viable Bacteria combined with warm saline enema method.After treatment,feeding intolerance,gestational defecation age,weight gain,full-milk feeding age and adverse reactions were compared between the two groups.Results The total incidence of feeding intolerance in the observation group at 72 hours and 15 days after birth were lower than those in the control group;the age at the end of defecation and the day of full milk feeding in the observation group were shorter than those in the control group;the growth of body weight in the observation group after birth was greater than that in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application of Bifidobacteria Triple Viable Bacteria combined with warm saline enema in preterm infants with feeding intolerance is conducive to improving the situation of feeding intolerance,shortening the time of defecation and feeding time of milk volume,which is worthy of clinical promotion. 2020 Vol. 27 (10): 142-144 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 19 ) 145 Effect of Progesterone combined with Dydrogesterone in the treatment of threatened abortion OU Jia-min Objective To investigate the effect of Progesterone combined with Dydrogesterone in the treatment of threatened abortion.Methods Sixty patients with threatened abortion admitted to our hospital from July 2018 to July 2019 were enrolled in the study.They were divided into a reference group(30 cases)and an observation group(30 cases)according to the odd-even group method.The reference group was treated with Progesterone.The observation group was treated with Progesterone combined with Dydrogesterone.The human chorionic gonadotropin and progesterone levels,symptom relief and disappearance time,clinical efficacy,adverse reactions in two groups were compared.Results After treatment,the levels of human chorionic gonadotropin and progesterone were higher than those before treatment,and the levels of human chorionic gonadotropin and progesterone in the observation group were higher than those in the reference group,and the differences were statistically significant(P＜0.05).The symptom relief and disappearance time of the observation group were shorter than the reference group,and the differences were statistically significant(P＜0.05).The total effective rate of clinical treatment in the observation group(96.67%)was higher than that of the reference group(76.67%).The difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Progesterone combined with Dydrogesterone in the treatment of threatened abortion patients,can improve human chorionic gonadotropin,progesterone levels,shorten the time to symptom relief and the disappearance of symptoms,with less adverse reactions,higher clinical efficiency,rehabilitation of the disease promote. 2020 Vol. 27 (10): 145-147 [Abstract] ( 87 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 148 Clinical value of color Doppler ultrasonography in the diagnosis of deep venous thrombosis of lower extremities LIANG Zheng-qiao； XI Jia-jing； CHEN Xiang-jie Objective To analyze and evaluate the clinical value of color Doppler ultrasonography in the diagnosis of deep venous thrombosis of lower extremities.Methods Clinical data of 23 patients with deep vein thrombosis of lower extremities in our hospital from March 2017 to March 2019 were retrospectively analyzed and defined as observation group.During the same period,23 healthy people were selected as the control group.Both groups were examined by color Doppler ultrasound,the "gold standard" for the diagnosis of venous thrombosis of lower extremities with the result of venography.The inner diameters of the lower limb veins(bilateral common femoral vein[CFV],superficial femoral vein[SFV],popliteal vein[POV],posterior tibial vein[PTV],and medial sural vein[MGV])of the two groups were observed and compared.The color Doppler flow imaging(CDFI)values of CFV,SFV and POV were compared.The diagnostic accuracy and sensitivity of the observation group were recorded.Venous blood flows(systolic peak velocity,enddiastolic velocity,and resistance index)of the two groups were observed and compared.Results The diameters of CFV,SFV,POV,PTV and MGV in the observation group were higher than those in the control group,with statistically significant differences(P＜0.05).CDFI values of CFV,SFV and POV in the observation group were all lower than those in the control group,with statistically significant differences(P＜0.05).The diagnostic accuracy and sensitivity of the observation group were 91.30% and 90.91% respectively.The systolic peak velocity and end-diastolic velocity in the observation group were higher than those in the control group,and the resistance index was lower than that in the control group,with statistically significant differences(P＜0.05).Conclusion Color Doppler ultrasonography is effective in the diagnosis of deep venous thrombosis of the lower extremities.It can detect the lower extremity venous diameter index and CDFI values,and has high diagnosis accuracy and sensitivity,which can provide a basis for clinical diagnosis and subsequent treament which is suitable for popularization. 2020 Vol. 27 (10): 148-150转154 [Abstract] ( 79 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 151 Application value of color Doppler ultrasound in the diagnosis of liver cirrhosis CHEN Qing； XIONG Mei-e； LIU Rong Objective To explore the application value of color Doppler ultrasound in the diagnosis of liver cirrhosis.Methods Fifty patients suspected with liver cirrhosis who were treated in our hospital from June 2017 to June 2019 were enrolled in the study.All patients underwent color Doppler ultrasound and magnetic resonance imaging(MRI).The pathological biopsy results were used as the gold standard,the accuracy,sensitivity and specificity of color Doppler ultrasound and MRI in the diagnosis of liver cirrhosis were compared and analyzed.Results A total of 48 cases of liver cirrhosis were detected by pathological biopsy,46 cases of liver cirrhosis were detected by color Doppler ultrasound,and 48 cases of liver cirrhosis were detected by MRI.There were no significant differences in the diagnostic results of color Doppler ultrasound,MRI and pathological biopsy(P＞0.05).There were no significant differences in the accuracy,sensitivity,and specificity between color Doppler ultrasound and MRI diagnosis(P＞0.05).Conclusion Color Doppler ultrasound has significant value in the diagnosis of liver cirrhosis.It can evaluate the hemodynamic changes and diameter of portal vein and its branches,and judge the degree of liver cirrhosis damage. 2020 Vol. 27 (10): 151-154 [Abstract] ( 68 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 155 Clinical effect of Budesonide Formoterol Powder Inhalation in the treatment of elderly patients with chronic obstructive pneumonia CHEN Ming-di； CHENG Ming-jian； HUANG Xiao-xia Objective To analyze the effect and compliance of Budesonide Formoterol Powder Inhalation in elderly patients with chronic obstructive pneumonia.Methods A total of 134 elderly patients with chronic obstructive pneumonia who were treated in our hospital from May 2017 to April 2018 were selected as the study subjects.They were divided into control group(n=67)and observation group(n=67)by odd and even grouping method.Patients in the control group received conventional treatment,and patients in the observation group received Budesonide Formoterol Powder Inhalation on the basis of the control group.The clinical efficacy,asthma symptom score,the ratio of maximum peak expiratory flow rate(PEF)accounting for the estimated value,compliance and adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group(97.01%)was higher than that of the control group(85.07%),and the difference was statistically significant(P＜0.05).The scores of asthma symptoms in the two groups after treatment were lower than those before treatment,and the ratio of PEF accounting for the estimated value in the two groups after treatment were higher than those before treatment,with statistically significant differences(P＜0.05).The score of asthma symptoms in the observation group after treatment was(0.24±0.02)points,which was lower than that in the control group of(0.41±0.04)points,the ratio of PEF accounting for the estimated value in the observation group after treatment was(97.22±9.46)%,which was higher than that in the control group of(89.27±8.75)%,with statistically significant differences(P＜0.05).The total compliance rate of the observation group during treatment was 98.51%,which was higher than that of the control group(88.06%),with statistically significant difference(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Patients with chronic obstructive pneumonia in the elderly who are treated with Budesonide Formoterol Powder Inhalation have better effect and have high therapeutic compliance.The adverse reactions during treatment are fewer and worthy of being promoted and applied. 2020 Vol. 27 (10): 155-158 [Abstract] ( 70 ) HTML (38 KB)  PDF  (0 KB)  ( 10 ) 159 Effect and safety of Valsartan combined with Amlodipine Besylate in treatment of hypertension KONG Su-nan Objective To investigate the effect and safety of Valsartan combined with Amlodipine Besylate in treatment of hypertension.Methods A total of 107 cases of patients with hypertension and who treated in our hospital from September 2017 to September 2018 were selected as the research objects in this study,and the patients were divided into the reference group(53 cases)and the study group(54 cases)according to the random number table method.The reference group were treated with Amlodipine Besylate,while the study group were treated with Valsartan combined with Amlodipine Besylate.The clinical effect,the blood pressure level and adverse reactions before and after treatment of two groups of patients were compared.Results The total effective rate in the study group was higher than that in the reference group,and the difference was statistically significant(P＜0.05).Before the treatment,the levels of systolic blood pressure(SBP)and diastolic blood pressure(DBP)between two groups were compared,and there was no significant difference(P＞0.05).After the treatment,the levels of SBP and DBP of two groups were lower than those before treatment,and the levels of SBP and DBP in the study group were lower than those in the reference group,and the differences were statistically significant(P＜0.05).The total incidence adverse reactions between the two groups was compared,and there was no significant difference(P＞0.05).Conclusion The clinical effect of Valsartan combined with Amlodipine Besylate in treatment of hypertension is significant,which can effectively improve the SBP and DBP pressure of patients,and the adverse reactions are less,thus it is worth promoting and applying. 2020 Vol. 27 (10): 159-161 [Abstract] ( 94 ) HTML (31 KB)  PDF  (0 KB)  ( 13 ) 162 Clinical efficacy analysis of floating needle therapy in the treatment of dorsal myofasciitis HU Qian-hua; LI Gui-feng; QUAN Jian-qiang; HU Zhi-qiang Objective To evaluate the application effect of floating needle therapy in the treatment of dorsal myofasciitis.Methods A total of 90 cases of dorsal fasciitis from July 2018 to June 2019 in Ji′an Hospital of Shanghai Oriental Hospital were selected as the subjects,and were divided into acupuncture group,floating needle group and drug group,30 cases in each group.Acupuncture group adopted acupuncture method,floating acupuncture group adopted needle acupuncture method and reperfusion treatment method,patients in the drug group were treated with Celecoxib.The visual analogue scale score,the grade of the tenderness score and total effective rate of treatment were compared among the three groups.Results The score of visual analogue scale in the floating needle group was lower than that in the drug group,and the difference was statistically significant(P＜0.05).The score of visual analogue scale in the floating needle group was lower than that in the acupuncture group,and the difference was statistically significant(P＜0.05).There was no significant difference in the score of visual analogue scale between the acupuncture group and the drug group(P＞0.05).The the grade of the tenderness score of the floating needle group was better than that of the acupuncture group and the drug group,and the differences were statistically significant(P＜0.05).There was no significant difference in the the grade of the tenderness score in acupuncture group and drug group(P＞0.05).The total effective rate of the floating needle group was higher than that of the acupuncture group,and the difference was statistically significant(P＜0.05).The total effective rate of the floating needle group was higher than that of the drug group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total effective rate between the acupuncture group and the drug group(P＞0.05).Conclusion Floating needle therapy has good effect in the treatment of dorsal myofasciitis and is worthy of clinical promotion. 2020 Vol. 27 (10): 162-165 [Abstract] ( 79 ) HTML (38 KB)  PDF  (0 KB)  ( 11 ) 166 Effect of Mecobalamin combined with Huangqi Guizhi Decoction in the treatment of diabetic foot ZHENG Mei-lin; LIN Rui-fang; CHEN Sheng-wen Objective To investigate the effect of Mecobalamin combined with Huangqi Guizhi Decoction in the treatment of diabetic foot and its effect on microinflammation stage.Methods A total of 84 cases of diabetic foot patients treated in our hospital from January 2018 to March 2019 were selected as the research objects.According to the random number table method,they were divided into observation group and control group,42 cases in each group.The patients in the control group received basic treatment and Mecobalamin treatment,while the patients in the observation group received Huangqi Guizhi Decoction on this basis for 4 weeks.The improvement time of foot symptoms clinical efficacy and the changes of facting plasma glecose(FPG),2-hour postprardial blood glucese(2 h PG),glycated hemoglobin(HbA1c),serum tumor necrosis factor-α(TNF-α)and hypersensitive c reactive protein(hs-CRP)before and after treatment were compared between the two groups.Results After treatment,FPG,2 h PG and HbA1c in the observation group were(5.73±1.14),(8.07±1.53)mmol/L,(6.21±0.84)%,respectively,which were lower than those in the control group for(6.23±0.74),(9.27±0.93)mmol/L,(6.92±0.62)%,the differences were of statistically significant(P＜0.05).The TNF-α and hs-CRP were(9.54±2.32)ng/L and(4.05±1.12)mg/L respectively,which were lower than those of the control group for(12.37±2.65)ng/L and(5.32±1.23)mg/L,the differences were of statistically significant(P＜0.05).The time of existence and healing of foot granulation tissue in the observation group were(4.97±1.17)and(18.94±3.79)d,respectively,which were shorter than those in the control group for(6.25±1.42)and(23.79±5.05)d,the differences were of statistically significant(P＜0.05);The total effective rate of the observation group was 90.48%,which was higher than that of the control group(78.57%),the difference was of statistically significant(P＜0.05).Conclusion Huangqi Guizhi Decoction can effectively improve the symptoms of diabetic foot by reducing blood sugar and improving microinflammation. 2020 Vol. 27 (10): 166-169 [Abstract] ( 82 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 170 Clinical effect of Dieda Fengshi Plaster combined with intra-articular injection of Sodium Hyaluronate Injection in the treatment of knee osteoarthritis with wind-cold-damp impediment type LI Si-ren; FU Zhao-cheng; LIU Zhi-jun Objective To investigate the clinical effect of Dieda Fengshi Plaster intra-articular injection of Sodium Hyaluronate Injection in the treatment of knee osteoarthritis with wind-cold-damp impediment type.Methods A total of 60 patients with osteoarthritis with wind-cold-damp impediment type admitted to No.1 Traditional Chinese Medicine Hospital in Changde from July 2018 to June 2019 were selected as the subjects and randomly divided into control group(30 cases)and treatment group(30 cases)by random table method.The control group was treated with Fortaline(Diclofenac Diethylamine Latex)combined with intra-articular injection of Sodium Hyaluronate Injection,the treatment group was treated with Dieda Fengshi Plaster combined with intra-articular injection of Sodium Hyaluronate Injection.The scores of pain,osteoarthritis score and the total effective rate of clinical treatment between the two groups were compared.Results The visual analogue scale(VAS)score of knee joint of treatment group was lower than those in control group,and the difference was statistically significant(P＜0.01).The scores of western Ontario and Mc Master universities osteoarthritis index(WOMA)and the total score of treatment group were all lower than those in control group,and the differences were statistically significant(P＜0.05).The total effective rate of clinical treatment in the treatment group was higher than that in control group，and the difference was statistically significant(P＜0.05).Conclusion Dieda Fengshi Plaster combined with intra-articular injection of Sodium Hyaluronate Injection in the treatment of knee with osteoarthritis with wind -cold -damp impediment type has good efficacy and it is helpful to improve symptoms.It can obviously relieve pain,improve knee joint function,relieve rheumatism,chills and pain. 2020 Vol. 27 (10): 170-173 [Abstract] ( 71 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 174 Investigation on current situation of pre-hospital first aid knowledge,attitude and behaviors of the masses in Nanhai District of Foshan City LUO Jian-wen； WU Guo-xin； DENG Chun； CAI Yang-lin； GUAN Zi-yun； WU Zhi-xin Objective To explore the current situation of pre-hospital first aid knowledge,attitude and behaviors of the masses in Nanhai District of Foshan City.Methods A total of 967 people in Nanhai District were selected by cluster sampling from October 2018 to May 2019,and the current situation of pre-hospital first aid knowledge,attitudes and behaviors of the participants were investigated by questionnaire.Results The awareness rate of 967 Nanhai residents about pre-hospital first aid knowledge was 72.80%.There were higher awareness rates of pre-hospital first aid knowledge among ＞30-50 years old,medical workers,police and people with college degree or above.The scores of pre-hospital first aid attitude and behaviors were(33.32±2.65)and(26.49±2.09)points,respectively.There were significant differences in the scores of pre-hospital first aid attitude among different age,occupation and education(P＜0.05).The pre-hospital first aid attitude and behaviors score of ＞31-40 years old group was the highest,followed by ＞20-30 years old group and ＞40-50 years old group.The scores of pre-hospital first aid attitude and behaviors of medical workers and police were the highest,while the scores of farmers and workers were lower.The scores for pre-hospital first aid attitude and behaviors of doctors were the highest,followed by masters and bachelors,and the score for pre-hospital first aid attitude and behaviors of people receiving primary school education was the lowest.Conclusion People in Nanhai District have a high awareness rate of pre-hospital first aid knowledge,a relatively active attitude and participation in pre-hospital first aid.Among them,rural residents,those with lower education levels and younger ages have different pre-hospital first aid knowledge,attitude and behaviors.The pre-hospital first aid knowledge popularization and relevant skills training should be widely carried out,and relevant laws should be issued to protect the rescuers. 2020 Vol. 27 (10): 174-176转181 [Abstract] ( 66 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 177 Analysis of influencing factors of pathological network use of middle school students in Longhua District,Shenzhen City YANG Wei-kang； LUO Bi-yun； XUE Zhi-qiang Objective To understand the pathological network use and influencing factors of middle school students in Longhua District,Shenzhen City,and to provide theoretical basis for the school and family in the district to take interventions to prevent and control the use of pathological networks.Methods A stratified random cluster sampling method was used to select the middle school students in Longhua District,Shenzhen City in November 2016 for a questionnaire survey.Univariate and multivariate analysis were performed using the χ2-test and Logistic regression model,respectively.Results The number of pathological network use in 3445 middle school students was 266,and the detection rate was 7.7%.The satisfaction degree of parents,the purpose of Internet access,depression disorder and anxiety emotional disorder were the influencing factors of pathological network use in middle school students(P＜0.05),the OR values were as follows.The satisfaction degree of parents：unsatisfactory OR=4.011(95%CI：2.305-6.980),very dissatisfied OR=4.874(95%CI：1.809-13.135);the main purpose of Internet access：playing the games OR=8.208(95%CI：4.479-15.043),chatting OR=3.301(95%CI：1.504-7.248),entertainment OR=2.217(95%CI：1.178-4.173);depression disorder OR=2.283(95%CI：1.604-3.629)and anxiety emotional disorder OR=2.386(95%CI：1.699-3.352).Conclusion Middle school students in Longhua District,Shenzhen City,have a moderate level of pathological network use.The depression disorder,anxiety emotional disorder,playing games,chatting and entertainment for the main purpose of Internet access are risk factors of pathological network use in middle school students in Longhua District,Shenzhen City.Schools and families in this district should take targeted measures to prevent and control the pathological network use of middle school students. 2020 Vol. 27 (10): 177-181 [Abstract] ( 66 ) HTML (38 KB)  PDF  (0 KB)  ( 11 ) 182 Retrospective analysis of 456 severe adverse drug reactions in our hospital SU Jin； YI Wen-yan； WANG Shi-yu Objective To analyze the characteristics of severe adverse drug reactions(ADR)in our hospital,to provide a reference for rational and safe drug use in clinic,and to reduce the incidence of drug-induced diseases.Methods A total of 456 severe ADR reports from January 2014 to December 2018 in our hospital were collected,and analysis was performed from the patients′ age,gender,affected organs,drug types,route of administration,and outcomes.Results The proportion of male and female patients with severe ADR was almost same as 1.05∶1.Most of the patients were over 49 years old(＞49 years old)accounting for 59.6%,and most of them occurred within 7 days of medication.The most frequently reported types of drugs were anti-tumor drugs,anti-tuberculosis drugs,and antibacterial drugs,accounting for 59.98%,14.58% and 13.11% respectively.The severe ADR occured most in combined use of drugs.The main route of administration was intravenous infusion,and the clinical manifestations were more common in blood system damage,hepatobiliary system and endocrine system damage.Conclusion The ADR monitoring of anti-tumor drugs,anti-tuberculosis drugs and antibacterial drugs should be paid great attention.Medication monitoring should be strengthened,and preventive measures should be taken to ensure the drug safety. 2020 Vol. 27 (10): 182-184转188 [Abstract] ( 75 ) HTML (29 KB)  PDF  (0 KB)  ( 15 ) 185 Analysis of the utilization of blood components in Yunfu City from 2015 to 2018 WU Cai-fa； WU Jun-ying Objective In order to understand the utilization status of blood components in Yunfu city,to analyze the preparation,supply and inventory of component blood in our city from January 2015 to December 2018.Methods Based on the information about preparation of blood components,finished products and movements of blood resource in and out of stock,a statistic analysis of preparation,supply and plasma inventory of erythrocytes,plasma,platelets,cryoprecipitates in our station was made from 2015 to 2018.Results From 2015 to 2018,the utilization rates of erythrocytes,plasma,platelets and cryoprecipitates were 94.17%,51.62%,97.62% and 98.03%,respectively.The utilization rate of frozen plasma was 11.39%,and that of fresh frozen plasma was 9.55%.A total of 14 154.0 U was scrapped due to lipid blood,leakage,unqualified examination,etc.,and the(fresh)frozen plasma stock reached 60 814.5 U.The utilization rate of virus inactivated(fresh)frozen plasma was more than 85.00%.4362.0 U was scrapped due to lipid blood,leakage,unqualified examination,etc.,at present,the stock of virus inactivated frozen plasma was 8924.5 U. Conclusion Through the systematic statistical analysis,the blood composition can be reasonably and scientifically prepared,so as to reduce the resource obsolescence or overstocking due to overdue,and reasonably utilize the surplus plasma. 2020 Vol. 27 (10): 185-188 [Abstract] ( 67 ) HTML (31 KB)  PDF  (0 KB)  ( 16 ) 189 Retrospective analysis of 99 adverse drug reaction reports in a hospital LIN Xiao-xia Objective To retrospective analyze the characteristics and regularity of adverse drug reactions(ADR)in our hospital,so as to provide reference for clinical rational drug use and risk prevention.Methods A total of 99 cases of ADR reported by our hospital from January 2018 to June 2019 were collected.The sex and age of patients，the route of administration，the types of drugs,ADR involved organs or systems and clinical manifestation,degree grade outcome and relevance evaluation,combined medication,etc.were analyzed retrospectly.Results In 99 ADR reports,women outnumbered men,and the incidence of ADR was higher in children under 12 years old and patients aged 21-50 years old;87 cases(87.88%)were mainly administered intravenously;the main drugs involved in ADR were anti infective drugs and anti-tumor drugs,with the composition ratio of 50.51% and 22.22% respectively;the clinical manifestations of ADR were mainly skin and accessory damage and blood system damage;the general ADR was 64 cases(64.65%),severe ADR was 35 cases(35.35%),mainly anti-tumor drugs.ADR caused by combined drugs was 28 cases(28.28%).Conclusion ADR are related with many kinds of factors． In clinical practice,the administration of drugs for special population should be strengthen,ADR monitoring of intravenous routes of administration should be emphasized,and the use of anti-infection drugs and anti-tumor drugs should be emphasized.Strengthen ADR reporting quality and management system,discover drug use safety risks in time,ensure public drug use safety,and promote clinical rational drug use. 2020 Vol. 27 (10): 189-192 [Abstract] ( 77 ) HTML (42 KB)  PDF  (0 KB)  ( 13 ) 193 Investigation on the frequency of instruments used in operating room with conventional configuration and study on the relevance between the operating cost of disinfection supply room LIU Su-mei； FU Hong-qun Objective To investigate the correlation between the frequency of instruments used in routine operating room and the operating cost of disinfection supply room.Methods From January 2018 to January 2019,100 operating room instruments packages with 40 instruments in each pack were selected,including 4000 operating room instruments.The frequency of use of 4000 operating room instruments without special conditions was investigated,and the correlation between them and the operating cost of disinfection supply room was analyzed.Results A total of 100 sets of instruments in the existing configuration，the average number of pieces used in a single package was 28.45,the average usage frequency of single package device was 71.13%;18 cm curved forceps,18 cm tissue forceps,needle holder,22 cm tissue shear,18 cm wire scissors,abdominal retractor,12.5 cm toothed,knife handle 4,edentulous oval forceps were used more frequently(>70%);The total operating cost of the disinfection supply room was(3 934 832.0±847 700.0)yuan.Pearson analysis showed that there was a positive correlation between the operating frequency of the operating room and the operating cost of the disinfection supply room(r=0.971,P=0.001).Conclusion There is a positive correlation between the frequency of operating room instruments and the operating cost of disinfection supply room.In order to avoid waste of medical cost,operating room instruments should be reasonably equipped. 2020 Vol. 27 (10): 193-196 [Abstract] ( 63 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 197 Application effect of integrated operation of supply room and operating room in surgical instrument management XU Yong-ying； LUO Si-min Objective To analyze the application effect of integrated operation of supply room and operating room in surgical instrument management.Methods Our hospital implemented the integrated operation of supply room and operating room from January to December 2017.The management of the operating room equipment and the working hours of the medical staff before and after the operation of the model were compared.Results After the integrated operation of the supply room and the operating room,the qualified clearance rate and qualified rate of the surgical instruments were higher than those before the implementation,and the differences were statistically significant(P＜0.05).After the integrated operation of the supply room and the operating room,the working time of the operating room and the supply room were shorter than those before the implementation,with statistical significance(P＜0.05).After the integrated operation in the supply room and the operating room,the washing and packaging quality scores of the staff were higher than before the implementation,with statistical significance(P＜0.05).Conclusion The integrated operation of the supply room and the operating room can improve the management quality of the surgical instruments and reduce the working hours of the operating room staff. 2020 Vol. 27 (10): 197-199转203 [Abstract] ( 82 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 200 Testicular mixed germ cell tumor: a case report and literature review YOU Xiang-yun； YI Cheng； YU Jun-feng； SHI Yang-sheng； SHAN Bao-hua Testicular mixed germ cell tumor(TMGCT)is very rare and highly malignant tumor,which mostly occurs in young people,with concealed symptoms,and is easily misdiagnosed and underdiagnosed in clinical practice.One case of TMGCT is reported,and the clinical features,diagnosis and treatment are analyzed in correlation with literature in order to improve the overall understanding of TMGCT,so as to choose a more reasonable treatment method and to enhance the survival rate of patients. 2020 Vol. 27 (10): 200-203 [Abstract] ( 59 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 204 Extracorporeal membrane oxygenation combined with intra-aortic balloon pump for the emergency treatment of cardiac arrest following large areas of acute myocardial infarction: a case report and literature review DING Rong-ming； ZHONG Gao-jun； WEN Zhong-yu； ZHONG Yi-ming； XIE Dong-ming； XIE Jia-he Myocardial infarction is a common cardiovascular disease characterized by a high incidence and a poor prognosis.Studies have shown that the severe cardiac complications are associated with the prognosis of myocardial infarction,and cardiac arrest is one of the serious complications.At present,there are limited treatment approaches for cardiac arrest,and these patients are associated with a poor prognosis and a high mortality.This article presented a case：appling extracorporeal membrane oxygenation(ECMO)and intra-aortic balloon pump(IABP)to successfully treat a patient with cardiac arrest following the large areas of acute myocardial infarction,so as to provide a reliable reference for patients with severe heart disease such as myocardial infarction complicated with cardiac arrest. 2020 Vol. 27 (10): 204-207 [Abstract] ( 64 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 208 Application of specialized preoperative visit based on the concept of enhanced recovery after surgery in patients undergoing laparoscopic hepatectomy TIAN Chun-mei； DING Ru-lei ； ZENG Gu-qing Objective To investigate the application effect of specialized preoperative visits based on the concept of enhanced recovery after surgery(ERAS)in patients undergoing laparoscopic hepatectomy.Methods A total of 80 patients undergoing laparoscopic hepatectomy in a tertiary class A hospital in Hengyang from January to December 2018 were selected and divided into the intervention group(n=40)and the control group(n=40)according to the admission sequence number .The control group received routin preoperative visit,the intervention group received specialized preoperative visits based on the ERAS concept.The anxiety scores before and after the visit,the incidence of postoperative operating room-related complications and the postoperative rehabilitation were compared between two groups.Results The anxiety score of patients in the intervention group in 5 minutes after entering the operating room was lower than that in the control group,and the difference was statistically significant(P＜0.05).The total incidence of postoperative operating room-related complications and the incidence of moderate to severe pain were lower in the intervention group than those in the control group,the differences were statistically significant(P＜0.05).The time of first eating,activity without bed,exhaust after operation and total hospital stay were shorter in the intervention group than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Applying specialized preoperative visits based on the ERAS concept to patients undergoing laparoscopic hepatectomy can effectively relieve anxiety,reduce surgical stress,and promote postoperative recovery,shorten hospital stay. 2020 Vol. 27 (10): 208-211 [Abstract] ( 74 ) HTML (38 KB)  PDF  (0 KB)  ( 10 ) 212 Effect of peer education on psychological status of patients with condylomaacuminata undergoing photodynamic therapy ZHENG Xia； TAO Xiao-hua； SHUAI Ci-dan； FAN Qing-qing Objective To explore effect of peer education on psychological status of patients with condylomaacuminatum(CA)undergoing photodynamic therapy.Methods A total of 86 CA patients undergoing photodynamic therapy who were admitted to our hospital from March 2018 to March 2019 were enrolled.They were divided into observation group and control group by simple random sampling method,43 cases in each group.The control group was given routine nursing.On this basis,observation group was additionally given peer education.Both groups were continuously intervened for 3 months.After intervention,treatment compliance in both groups was recorded.The psychological status of both groups was assessed by self-rating depression scale(SDS)and self-rating anxiety scale(SAS).Results After intervention,treatment compliance rate of observation group(83.72%)was higher than that of control group(65.12%),the difference was statistically significant(P＜0.05).After intervention,SAS and SDS scores of observation group were lower than those of control group,the differences were statistically significant(P＜0.05).Conclusion Peer education can further improve treatment compliance and psychological status of CA patients undergoing photodynamic therapy. 2020 Vol. 27 (10): 212-214 [Abstract] ( 69 ) HTML (30 KB)  PDF  (0 KB)  ( 16 ) 215 Effect of personalized pain nursing on physiological stress response and pain level in patients with emergency kidney stones ZHONG Li-ling Objective To explore the effect of personalized pain nursing on physiological stress response and pain level in patients with emergency kidney stones.Methods Sixty patients with emergency kidney stones admitted to our hospital from January to December 2015 were selected and divided into control group and study group according to random number table method,30 cases in each group.The control group received routine nursing,patients in the study group received personalized pain nursing.The scores of visual analogue scale(VAS),self-rating anxiety scale(SAS),self-rating depression scale(SDS),Pittsburgh sleep quality index scale(PSQI),and postoperative blood pressure and heart rate changes were compared between the two groups.Results There was no significant difference in pain degree between the two groups before intervention(P＞0.05).The pain degree of the two groups was lower than that of the before the intervention,and which in the study group was lighter than that in the control group.The differences were statistically significant(P＜0.05).There were no significant differences in the scores of SAS,SDS,VAS and PSQI between the two groups before intervention(P＞0.05).After the intervention,the scores of SAS,SDS,VAS and PSQI the two groups were lower than that of before the intervention,and which in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).The postoperative heart rate,diastolic blood pressure and systolic blood pressure in the study group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Personalized pain nursing in patients with emergency kidney stones can effectively alleviate the pain level,improve mental state and sleep quality,and reduce the physiological stress response of patients. 2020 Vol. 27 (10): 215-217 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 218 Application effect of psychological nursing based on Maslow′s hierarchy of needs theory in patients with lung cancer undergoing radiotherapy HU Chun-yi Objective To explore the application effect of psychological nursing based on Maslow′s hierarchy of needs theory on self-efficacy and resilience of patients with lung cancer undergoing radiotherapy.Methods The clinical data of 80 patients with lung cancer undergoing radiotherapy who were admitted to our hospital from January 2015 to February 2018 were retrospectively analyzed.According to different nursing methods,they were divided into the intervention group(n=45)and the routine group(n=35).The intervention group was given psychological nursing based on Maslow′s hierarchy of needs theory while the routine group was given routine psychological nursing.Scores of the general self-efficacy scale(GSES),the Connor-Davidson resilience scale(CD-RISC)and the Newcastle nursing service satisfaction scale(NSNA)scores were compared between the two groups.Results After 3 months of intervention,scores of GSES and CD-RISC of the intervention group were higher than those of the routine group(P＜0.05).The scores of five dimensions(nurses′ attention to themselves,nurses′ accessibility,professional knowledge reserves,care accessibility and care efficiency）of NSNA were also higher than those of the routine group(P＜0.05).Conclusion The application of psychological nursing based on Maslow′s hierarchy of needs theory on self-efficacy and resilience of patients with lung cancer undergoing radiotherapy can enhance patients′ self-confidence and coping ability while facing problems,and improve their satisfaction with nursing services. 2020 Vol. 27 (10): 218-220转224 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 14 ) 221 Application effect of personalized psychological nursing intervention in the diagnosis and treatment of patients with electronic bronchoscopy DING Yi-mei Objective To analyze the effect of personalized psychological nursing intervention on patients undergoing electronic bronchoscopy.Methods From October 2017 to January 2019,60 patients who underwent electronic bronchoscopy in our hospital were selected as the research subjects.They were divided into control group(n=30)and research group(n=30)by blind selection method.The patients in the control group received routine nursing,while those in the research group received basic nursing plus personalized psychological nursing intervention.The changes of vital signs,adverse psychological status and adverse reactions before and after treatment were compared between the two groups.Results There were no significant differences in heart rate,systolic blood pressure and oxygen saturation between the two groups before and after treatment(P＞0.05).Heart rate and systolic blood pressure in the research group were lower than those in the control group,and oxygen saturation in the blood was higher than that in the control group in diagnosis and treatment(P＜0.05).The heart rate,systolic blood pressure and oxygen saturations in the control group were significanty different between those before and after diagnosis and treatment(P＜0.05).There were no significant differences in heart rate,systolic blood pressure and oxygen saturation in,after diagnosis and treatment in the research group than those before diagnosin and treatment(P＞0.05).There were no significant differences in the scores of SAS and SDS between the two groups before diagnosis and treatment(P＞0.05).The scores of SAS and SDS after diagnosis and treatment in the two groups were lower than those before diagnosis and treatment,the differences were no statistially significant(P＞0.05).The scores of SAS and SDS in the research group after diagnosis and treatment were lower than those before diagnosis and treatment and the control group(P＜0.05）.The total incidence of adverse reactions in the research group was lower than that in the control group(P＜0.05).Conclusion Personalized psychological nursing intervention applied in the diagnosis and treatment of patients with electronic bronchoscopy can significantly improve the negative emotions of patients,reduce physical and psychological stress reaction,reduce the incidence of adverse reactions to surgery,improve the effect of examination and nursing quality,which is worthy of clinical reference and application. 2020 Vol. 27 (10): 221-224 [Abstract] ( 77 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 225 Application effect of enhanced recovery after surgery in rehabilitation nursing during perioperative period of laparoscopic hepatectomy WU Na； YU Dan Objective To explore application effect of enhanced recovery after surgery(ERAS)in rehabilitation nursing during perioperative period of laparoscopic hepatectomy.Methods A total of 120 patients who underwent laparoscopic hepatectomy in our hospital from April 2017 to April 2019 were enrolled.They were divided into control group(n=60)and observation group(n=60)by random number table method.The control group was given routine nursing,while observation group was given ERAS nursing.The postoperative recovery conditions,liver function indexes and degree of depression and anxiety were compared between the two groups.Results The postoperative first anal exhaust time,leaving bed time and hospital stay in observation group were shorter than those in control group(P＜0.05).After nursing intervention,levels of direct bilirubin(DBil)and indirect bilirubin(IBil)in observation group were lower than those in control group(P＜0.05),while level of serum albumin(ALB)was higher than that in control group(P＜0.05).After nursing intervention,scores of depression and anxiety degree in observation group were lower than that in control group,with statistical differences(P＜0.05).Conclusion ERAS nursing can shorten postoperative recovery time of patients,significantly reduce degree of depression and anxiety,and effectively improve liver function indexes. 2020 Vol. 27 (10): 225-227 [Abstract] ( 81 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 228 Application effect of comprehensive nursing in laser combined with 5-Aminolevulinic Acid photodynamic therapy for patients in pregnancy complicated with vulvar condyloma acuminata WANG Yan； WANG Xia Objective To investigate the effect of comprehensive nursing in laser combined with 5-Aminolevulinic Acid(ALA)photodynamic therapy for patients with pregnancy complicated with vulvar condyloma acuminata.Methods One hundred patients in pregnancy combined with vulvar condyloma acuminata who were admitted to our hospital from February 2017 to February 2018 were enrolled in the study.They were divided into control group(n=50)and study group(n=50)according to computer random method.The control group received routine nursing,while the study group adopted comprehensive nursing.The nursing efficiency,recurrence rate,total adverse reaction rate,life quality score and total nursing satisfaction rate between the two groups were compared.Results There were no significant differences in the nursing efficiency and recurrence rate between the two groups(P＞0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).The total nursing satisfaction rate and life quality score of the study group were higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Laser combined with ALA photodynamic therapy for patients in pregnancy complicated with vulvar condyloma acuminatum,together with comprehensive nursing intervention can reduce the overall incidence of adverse reactions,and patients are satisfied with this nursing model. 2020 Vol. 27 (10): 228-230 [Abstract] ( 75 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 231 Application effect of hypnotic painless suggestion method in painless delivery of parturients ZHENG Yue-mei； HUANG Wei-chang Objective To explore the application effect of hypnotic painless suggestion method in painless delivery of parturients.Methods A total of 100 cases of painless childbirth in our hospital from July 2017 to December 2018 were selected as the research objects.According to random number table method,they were divided into control group(n=50)and observation group(n=50).The control group received routine childbirth nursing,while the observation group received hypnotic painless suggestion on the basis of the control group.The visual analogue score(VAS)during delivery,the duration of labor,the amount of postpartum hemorrhage,the outcome of the newborn and the mode of delivery were compared between the two groups.Results The VAS scores of the first,second and third stages of labor in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The duration of the first,second and third stages of labor in the observation group were shorter than that in the control group(P＜0.05).The amount of postpartum hemorrhage in the observation group was less than that in the control group,fetal distress rate and neonatal asphyxia rate in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The rate of cesarean section in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The application of hypnotic painless suggestion method in painless delivery of parturients can alleviate the pain of parturients,shorten the duration of labor,reduce postpartum hemorrhage and improve pregnancy outcomes. 2020 Vol. 27 (10): 231-233 [Abstract] ( 80 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 234 Application effect of high-quality nursing intervention on voluntary blood donors in blood stations YOU Hong-xia Objective To investigate the application effect of high-quality nursing intervention on voluntary blood donors in blood stations.Methods From January 2017 to February 2019,a total of 160 voluntary blood people in Zhongshan Central Blood Station were selected,they were divided into the conventional group(n=80)and the intervention group(n=80)according to random number table method.The conventional group received conventional nursing，and the intervention group adopted high-quality nursing intervention.The pain,blood scrapping rate,blood donation reaction and total nursing satisfaction were compared between two groups.Results The pain and blood scrapping rate of blood donation in the intervention group were lower than those in the conventional group,the differences were statistically significant(P＜0.05).The total satisfaction of the intervention group was higher than that in the conventional group,the difference was statistically significant(P ＜0.05).The total incidence of blood donation reaction in the intervention group was lower than that in the conventional group,the difference was statistically significant(P＜0.05).Conclusion The high-quality nursing intervention has a remarkable effect on blood quality,which can effectively alleviate the pain of voluntary blood donors,reduce the incidence of blood donation reactions and the rate of blood scrapping,and is worth promoting. 2020 Vol. 27 (10): 234-236 [Abstract] ( 61 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 237 Application effect of humanistic nursing in patients with appendicitis surgery WU Wen-yan; WU Mu-hua Objective To analyze the application effect of humanistic nursing in patients with appendicitis.Methods A total of 100 patients with appendicitis who underwent surgery from February 2017 to June 2019 in our hospital were selected as study subjects.According to the method of drawing,they were divided into reference group(n=50)and experimental group(n=50).The experimental group adopted humanistic nursing,the reference group used the routine nursing intervention method.The clinical nursing satisfaction,anxiety score,depression score,pain score,first exhaust time,bowel sound recovery time,and first defecation time were compared between the two groups.Results After nursing,the clinical nursing total satisfaction of the experimental group was higher than that of the reference group.The total complication rate,anxiety score,depression score,and pain score were lower than those of the reference group.The first exhaust time,the recovery time of the bowel sound,and the first defecation time were shorter than those of the reference.After nursing,the anxiety score,depression score and pain score of the experimental group and the reference group were lower than those before the nursing,and the differences were statistically significant(P＜0.05).Conclusion Humanistic nursing in patients with appendicitis surgery can help reduce the degree of pain and shorten the recovery time of various indicators. 2020 Vol. 27 (10): 237-239 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 240 Application of abnormal electrocardiogram waveform training in firstline nurses in patients with acute myocardial infarction BAI Yan-mei Objective To explore the application of abnormal electrocardiogram(ECG)waveform training in first-line nurses in patients with acute myocardial infarction(AMI).Methods Eighty patients with AMI admitted to our hospital from December 2017 to July 2019 were enrolled in the study.They were divided into observation group(n=40)and control group(n=40)according to the random number table method.In the control group,routine nursing was performed.The observation group focused on the implementation of abnormal ECG waveform training for the nursing staff.The time of arrhythmia and the hospitalization time after the onset were compared.The detection of arrhythmia during treatment and the successful treatment of the two groups were statistically analyzed.Results The time of recognition of arrhythmia and the hospital stay after onset were shorter in the observation group than those in the control group,with significant differences(P＜0.05).The detection rate of incidence of ventricular fibrillation,ventricular tachycardia and atrioventricular block in the observation group were higher than those in the control group,with significant differences(P＜0.05).The success rescuing rate of the observation group was higher than that of the control group,with significant difference(P＜0.05).Conclusion For arrhythmia after AMI,improving the recognition of nursing staff can effectively shorten the hospital stay,increase the discovery rate of arrhythmia,as well as the success rate of clinical treatment. 2020 Vol. 27 (10): 240-242 [Abstract] ( 72 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 243 Application effect of comprehensive nursing intervention on patients with urinary system disease complicated with diabetes FU Xue-lian； YANG Kai； HUANG Yong-xiang； LIU Yan-cong； GUAN Hong-ying Objective To explore the effect of nursing intervention on patients with urinary system disease and diabetes(DM).Methods A total of 62 patients with urinary system diseases and DM who were admitted to our hospital from June 2018 to May 2019 were selected as the research objects.According to the random number table method,they were divided into control group and study group,31 cases in each group.The control group was given routine nursing measures;the study group was given comprehensive nursing intervention,and the satisfaction of nursing service,selfrating anxiety(SAS)and depression scale(SDS)score,fasting and two-hour postprandial blood sugar control between the two groups were compared.Results The total satisfaction rate of nursing in the study group(93.55%)was higher than that in the control group(83.87%),with statistical difference(P＜0.05).There were no significant differences in SAS and SDS scores between the two groups before intervention(P＞0.05),SAS and SDS scores after intervention in both groups were lower than those before intervention,and SAS and SDS scores after intervention in the study group were lower than those of the control group,the differences were statistically significant(P＜0.05).The quality of life score of the study group after intervention was higher than that of the control group(P＜0.05);the fasting blood glucose and 2-hour postprandial blood glucose of the two groups after intervention were lower than those before intervention,and the fasting blood glucose,2 hours blood sugar of the study group after intervention were lower than those of the control group,the differences were statistically significant(P＜0.05).Conclusion In the implementation of comprehensive nursing measures for patients with urinary system diseases and DM can effectively help patients control blood sugar indicators,improve their clinical symptoms,alleviate bad psychological mood,and deepen the knowledge of health care and grasp.It is of great significance to improve their condition and quality of life through self-control in daily life. 2020 Vol. 27 (10): 243-245转249 [Abstract] ( 76 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 246 A case of specialist nursing for severe hypertriglyceridemia-induced pancreatitis with plasma exchange LI Si-rong； WANG Yuan-jie； LIU Fang-jiu； LIU Hua； HE Jiang； DU Wen-wu Severe pancreatitis caused by hypertriglyceridemia（HTG）is rare in clinic.In recent years,the incidence rate has gradually increased in the population and high level of hyperglycemia seriously affects the disease outcome of patients.The specialist nursing aims to improve the disease outcome of patients with early plasma exchange.This paper summarizes its specific program and experience,in order to provide a direction for the promotion of specialist nursing care in the treatment of severe HTG-induced pancreatitis with early plasma exchange. 2020 Vol. 27 (10): 246-249 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 250 Application of personality dynamic continuity nursing model on patients with early diabetic nephropathy HOU Li-hua； ZHANG Jing； YANG Qi； WANG Yu-ying； QI Li-na  Objective To explore the application of personality dynamic continuity nursing model on patients with early diabetic nephropathy(DN).Methods A total of 104 patients with early DN who were treated in our hospital from May 2018 to April 2019 were selected as research objects.The patients were divided into control group(n=52)and observation group(n=52)according to their bed numbers.The control group adopted routine nursing method,the observation group adopted personality dynamic continuity nursing mode for nursing intervention.After 3 months of nursing,the self-management scores,blood pressure and blood glucose measurement results were compared between the two groups.Results The self-management score of the observation group was higher than that of the control group after 3 months of nursing,and the difference was statistically significant(P＜0.05).The systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group after 3 months of nursing,and the differences were statistically significant(P＜0.05).The fasting blood glucose and postprandial blood glucose levels in the observation group were lower than those in the control group 3 months after nursing,and the differences were statistically significant(P＜0.05).Conclusion The personality dynamic continuity nursing mode for early DN patients nursing intervention,effectively improve the patients′ self-management ability,stabilized the blood pressure and blood sugar test results of patients,nursing effect is significant. 2020 Vol. 27 (10): 250- [Abstract] ( 79 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )

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