CT引导下穿刺注射医用胶精准定位肺内异物的实验研究

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Abstract Objective To establish a model of CT-assisted foreign bodies in lungs of Bama miniature pigs with built-in metal guidewire,and explore the model to study the feasibility and safety of medical glue to accurately locate foreign bodies in the lungs by CT-guided puncture injection after thoracoscopic removal of foreign bodies in the lungs.Methods Four Bama miniature pigs were selected,and 2 cm metal guidewire was inserted into the right lung of Bama mini pigs under CT guidance after anesthesia to simulate foreign bodies in the lungs.After using CT scan to determine the location of the foreign body,puncture and injection of medical glue was used to accurately locate the foreign body in the lung,and then the thoracoscopic removal of the foreign body in the lung was performed.Results Four Bama miniature pigs successfully established CT-assisted models for simulating foreign bodies in the lung with metal guidewire embedded in the lungs.The operation time was 6-9 minutes,with an average of(7.50±1.29)minutes.All CT-guided puncture injections of medical glue were used for localization.The operation time was 18-25 minutes,with an average of(21.25±2.99)minutes.Pneumothorax(25%)appeared in one pig after positioning.The amount of pneumothorax was small,untreated,no hemothorax,pulmonary embolism,and other complications.All Bama miniature pigs underwent thoracoscopy removal of foreign bodies in the lungs.The operation time was 46-93 minutes,with an average of(66.00±20.12)minutes.The location of the foreign body during the operation was 7-11 minutes,with an average of(8.75±1.71)minutes.The anatomy confirmed that after dissection of isolated pig lungs,the medical micelles were located beside the foreign bodies in the lungs.The diameter of the micelles was 8-12 mm,with an average of(9.50±1.91)mm.The distance between the micelles and the foreign objects in the lung was 9-13 mm,with an average of(11.00±1.83)mm.The positioning success rate was 100%.Conclusion The CT-assisted model for locating foreign bodies in Bama miniature pigs lungs with metal guidewire built into the lungs is established,and it is confirmed that the model is safe and feasible for CT-guided puncture and injection of medical glue to accurately locate foreign bodies and to perform thoracoscopic removal of foreign bodies in the lungs,which lays the foundation for further clinical application

Key words： CT localization Medical glue Foreign bodies in the lung Bama miniature pigs

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	Articles by authors
	DENG Shi-long
	XIE Yong-wei
	ZHOU Shun-kai
	YANG Jing-rong
	CHEN Xing-chi
	YANG Sheng-sheng

Cite this article:

DENG Shi-long,XIE Yong-wei,ZHOU Shun-kai, et al. Experimental study of precisely locating foreign body in the lung by CTguided puncture injection of medical glue[J]. 中国当代医药, 2020, 27(10): 9-12.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I10/9

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