不同剂量他汀类药物在急性心肌梗死早期患者中的应用效果比较

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Abstract Objective To compare the application effect of different dosage of statins in the early stage of acute myocardial infarction.Methods A total of 60 patients with early stage of acute myocardial infarction treated in our hospital from October 2017 to January 2019 were selected as the subjects.They were divided into experimental group and control group by random number table method,with 30 cases in each group.Patients in the experimental group were treated with Rosuvastatin 20 mg/d,while patients in the control group were treated with Rosuvastatin 10 mg/d,and the patients in both groups were treated for 6 months.The total effective rate,blood lipid index,C-reactive protein,blood pressure and adverse reactions of the two groups were compared.Results The total effective rate of the experimental group was 96.7%,higher than that of the control group(73.3%),the difference was statistically significant(P＜0.05).The levels of triacylglycerol,total cholesterol,low density lipoprotein and C-reactive protein in the experimental group were lower than those in the control group,and the level of high density lipoprotein was higher than that in the control group,the differences were statistically significant(P＜0.05).The systolic and diastolic blood pressure in the experimental group were lower than those in the control group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion In the early stage of acute myocardial infarction,20 mg/d Rosuvastatin can improve the clinical effect,improve the blood lipid index,C-reactive protein level,reduce the blood pressure,reduce the occurrence of adverse reactions,and have a higher safety.It is worthy of clinical application.

Key words： Different dosage of statins Acute myocardial infarction Early stage Therapeutic effect

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	CHENG Qian-kun

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CHENG Qian-kun. Applicatin effect comparison of different dosage of statins in the early stage of acute myocardial infarction[J]. 中国当代医药, 2020, 27(10): 50-52转59.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I10/50

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