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| Effect of Mecobalamin combined with Huangqi Guizhi Decoction in the treatment of diabetic foot |
| ZHENG Mei-lin LIN Rui-fang CHEN Sheng-wen |
| Department of Pharmacy,Shanwei People′s Hospital,Guangdong Province,Shanwei 516600,China |
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Abstract Objective To investigate the effect of Mecobalamin combined with Huangqi Guizhi Decoction in the treatment of diabetic foot and its effect on microinflammation stage.Methods A total of 84 cases of diabetic foot patients treated in our hospital from January 2018 to March 2019 were selected as the research objects.According to the random number table method,they were divided into observation group and control group,42 cases in each group.The patients in the control group received basic treatment and Mecobalamin treatment,while the patients in the observation group received Huangqi Guizhi Decoction on this basis for 4 weeks.The improvement time of foot symptoms clinical efficacy and the changes of facting plasma glecose(FPG),2-hour postprardial blood glucese(2 h PG),glycated hemoglobin(HbA1c),serum tumor necrosis factor-α(TNF-α)and hypersensitive c reactive protein(hs-CRP)before and after treatment were compared between the two groups.Results After treatment,FPG,2 h PG and HbA1c in the observation group were(5.73±1.14),(8.07±1.53)mmol/L,(6.21±0.84)%,respectively,which were lower than those in the control group for(6.23±0.74),(9.27±0.93)mmol/L,(6.92±0.62)%,the differences were of statistically significant(P＜0.05).The TNF-α and hs-CRP were(9.54±2.32)ng/L and(4.05±1.12)mg/L respectively,which were lower than those of the control group for(12.37±2.65)ng/L and(5.32±1.23)mg/L,the differences were of statistically significant(P＜0.05).The time of existence and healing of foot granulation tissue in the observation group were(4.97±1.17)and(18.94±3.79)d,respectively,which were shorter than those in the control group for(6.25±1.42)and(23.79±5.05)d,the differences were of statistically significant(P＜0.05);The total effective rate of the observation group was 90.48%,which was higher than that of the control group(78.57%),the difference was of statistically significant(P＜0.05).Conclusion Huangqi Guizhi Decoction can effectively improve the symptoms of diabetic foot by reducing blood sugar and improving microinflammation.
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