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Quick Search     Adv Search 2017 Vol. 24, No. 8 Published: 2017-03-18   9 Analysis of sMRI features of mild cognitive impairment and Alzheimer disease QI Xue-dan;XU Fan-yu;FAN Zhao Objective To investigate the characteristics of structural magnetic resonance imaging(sMRI)of mild cognitive impairment(MCI)and Alzheimer disease(AD)in differentbrain regions,and to find out the characteristic indexes so as to provide assistance for early diagnosis.Methods Altogether 543 patients whose number ranged from 4018 to 5210 in the Alzheimer Disease Neuroimaging Initiative(ADNI)database from August 2014 July 2015 were randomly selected as the object of this research and divided into four groups according to the ADNI database diagnostic standards:139 cases in normal cognitive function group(CN),220 cases in early mild cognitive impairment group(EMCI),108 cases in later mild cognitive impairment group(LMCI)and 76 cases in AD group.Mini-Mental State Examination(MMSE)and 272 sMRI data of all the subjects were acquired.And multiple statistics methods were used,including the single-factor variance analysis,multiple comparison,nonparametric test,paired comparison analysis and multiple linear regression analysis,to discover the characteristic index that can make prediction of disease.Results The analysis results showed that among 272 sMRI data,28 indexes of CN group,EMCI group,LMCI group and AD group had statistically significant difference,of which there were 22 indexes in the pairing locations of the left and right brain region.Through analysis of the left and right brain regions by using paired comparison,a more serious atrophy was seen in the left hemisphere.According to the multiple linear regression analysis of 28 sMRI data and MMSE,the lower volume of the left hippocampus played the biggest influence on the MMSE score.Conclusion With the development of MCI into AD,the degree of brain atrophy is gradually increasing,and the left hemisphere is more severe in the progression of disease,among which,the lower volume of the left hippocampal has the greatest influence on the MMSE score. 2017 Vol. 24 (8): 9-13转26 [Abstract] ( 167 ) HTML (57 KB)  PDF  (0 KB)  ( 27 ) 14 Systematic review and Meta analysis of the influence of insertion depth on marginal hard tissue of dental implants CHEN Shi-yu;LI Yun-sheng;SHAO Jian;JIANG Yan-jun Objective To review the change of marginal bone level around dental implants while inserted different depths.Achieving an ideal insertion depth to provide an theoretical basis and practical activity for clinical application. Methods A literature search of electronic databeses(PubMed,Medline,Embase,The Cochrane Library,CBM,CNKI,Wan-Fang)were performed up,and works published in the English and Chinese languge from January 1st,2006 to June 1st, 2016.Full-text analysis was performed in relevant publications,and to make data extraction,the quality evaluation. Revman 5.3 software was used for Meta analysis and forest plot drawing.The effect indexes were mean differences(MD) and 95%confidence intervals(CI).Results 105 studies were searched and 28 articles were preliminary chosen.After the full-text reading,5 articles were eventually included.Irrespective of platform switching,the marginal bone loss around implants in the crestal level was significantly less than the implants in the subcrestal level among the early stage after placements[MD=0.30,95%CI(0.20,0.39),P＜0.000 01].Subgroup analyses,2 articles were regarding of platform switching im plants,but no statistically significant difference was detected(P=0.99).4 articles were regarding of non-switched platform implants,Subgroup analyses showed thatthe marginalbone loss around cretalbone levelimplants was significantly less than the subcrestal bone levelimplants,respectively during the period of 3-6 months[MD=0.26,95%CI(0.15，0.38),P＜0.000 01]. And less bone lossin the above bone levelimplants than the crestalbone levelimplants in more than 1 year after prosthetic loading[MD=-0.59,95%CI(-0.72，-0.46),P＜0.000 01].Conclusion Implants in a subcrestal position may be associated with a higher amount of bone loss during the remodeling process than implants placed in an epior supracrestal position. 2017 Vol. 24 (8): 14-18 [Abstract] ( 171 ) HTML (54 KB)  PDF  (0 KB)  ( 38 ) 19 Research progress in the surgery treatment of esophagealand gastric cancer LIANG Jian;HUANG Jie;FU Yin;XIE Song-ping Esophageal and gastric cancer refers to the location independent primary tumor of the esophagus and stomach.Reconstruction of digestive tract after tumor resection is difficult,clinical treatment of patients with esophageal cancer and gastric cancer,most used non surgical treatment.This paper based on the clinical experience and reading reports,summarize the surgical treatment of esophageal cancer and gastric cancer in clinic.For different parts of the concurrent cancer of esophagus and stomach cancers,choosing a different surgical approach and reconstruction of digestive organs to make the surgical treatment of esophageal and gastric cancer. 2017 Vol. 24 (8): 19-26 [Abstract] ( 160 ) HTML (86 KB)  PDF  (0 KB)  ( 32 ) 27 Research progress of treatment of pulmonary metastases from hepatocellular carcinoma PENG Wei-zhong;YANG Mao-sheng Hepatocellular carcinoma(HCC)is one of the world′s most common malignant tumors and pulmonary metastasis is the most common distant metastases.In the event of pulmonary metastasis,development of deterioration is rapid, which often speed up the death.In this work,the treatment of pulmonary metastases from HCC,including surgical treatment,chemotherapy drugs,radiotherapy,minimally invasive treatment,molecular targeted drug therapy and combination therapy were discussed systematically,and the advantages and disadvantages of these treatments were discussed.The constructive suggestions on the choice of treatment regimen and the implementation details of individualized therapy were presented,and hope to give out some new insights for the development and selection of clinical treatment options in patients with pulmonary metastases from HCC in order to achieve individualized treatment,improve the patient′s survival and quality of life. 2017 Vol. 24 (8): 27-30 [Abstract] ( 143 ) HTML (55 KB)  PDF  (0 KB)  ( 38 ) 31 Clinical effect observation of laparoscopic ureterolithotomy and percutaneous nephrolithotomy in the treatment of complex upper ureteral calculi YU Quan-sheng;CHEN Meng;CHEN Zhi-yong;FAN Jian-hua;PANG Kun;ZHANG Wei;HAN Cong-hui Objective To compare the clinical effect of laparoscopic ureteroscopy and percutaneous nephrolithotomy in the treatment of complex upper ureteral calculi.Methods A clinical data of 67 patients with complex upper ureteral calculi from January 2012 to December 2015 in the WU Jie-ping Urology Center of People′s Hospital of Shuyang County and Department of Urology of Xuzhou Hospital Affiliated to Medical College of Southeast University were retrospectively analyzed.The patients were divided into the RLU group(n=31)and the PCNL group(n=36)according to the operation mode,and the operation time,intraoperative blood loss,stone clearance rate,maximum body temperature, time of catheter removal,and postoperative hospital stay were compared between the two groups.Results There was no significant difference between the two groups in the operation time,stone clearance rate and the maximum body temperature after operation(P＞0.05).The time of catheter removal,and postoperative hospital stay in the RLU group was shorter than that in the PCNL group,the amount of intraoperative blood loss in the RLU group was lower than that in the PCNL group,with significant difference (P＜0.01).Conclusion RLU is a safe treatment,and the treatment of upper ureteral calculi can shorten the length of hospital stay and reduce the amount of bleeding. 2017 Vol. 24 (8): 31-33转49 [Abstract] ( 134 ) HTML (42 KB)  PDF  (0 KB)  ( 36 ) 34 Principle of serum lipids changing in acute promyelocytic leukemia treated by Arsenic Trioxide combined with chemotherapy and its adverse reaction XU Li-ming Objective To study the changes of serum lipids and adverse reaction triggered by Arsenic Trioxide in acute promyelocytic leukemia with the combination of chemotherapy.Methods A total of 64 patients with acute promyelocytic leukemia in our department of internal medicine in our hospital from April 2005 to March 2015 were selected.The levels of serum total cholesterol(TC)and triacylglycerol(TG),adverse reactions,survival rate and recurrence rate were analyzed during combination of Arsenic Trioxide and chemotherapy.Results After 3 courses oftreatment,the indexes of TC and TG were both displayed increasing tendency with statistical differences(P＜0.05).The adverse reaction was mainly occurred in digestive system,and the most serious adverse reactions were bone marrow suppression and damages on the functions of liver and kidney.The survival rates 6,12,18 months after treatment was 96.77%,91.94%,85.48%respectively,the recurrence rate 6,12,18 months after treatment was 9.68%,6.45%,4.84%respectively.Conclusion In the clinical treatment of acute promyelocytic leukemia,combination of Arsenic Trioxide and chemotherapy will lead to the increase of serum lipids as well as many types of adverse reactions. 2017 Vol. 24 (8): 34-36 [Abstract] ( 168 ) HTML (38 KB)  PDF  (0 KB)  ( 46 ) 37 Application effect of early cluster strategy in integrated treatment of multiple trauma patients with traumatic brain injury ZOU Xian-ming;CHEN Fu-ping;WU Liu-zai Objective To investigate the application effect of early cluster strategy in the treatment of multiple trauma patients with traumatic brain injury.Methods From April 2013 to January 2016,52 cases of multiple trauma patients with traumatic brain injury were divided into control group(n=26)and observation group(n=26)according to the different treatment method.Patients in the control group received routine emergency treatment,and patients in the observation group were treated with early cluster therapy.Change of each index,Fugl-Meyer motor function (FMA score),Functional Independence Score (FM score),Glasgow coma scale (GCS score),and adverse event rate were compared between two groups before and after treatment.Results The level of PaO2,PaCO2,PaO2/FiO2and Hb at treatment for 1，24 h of the observation group was significantly higher than thatofthe control group(P＜0.05),and the levelof Lac at treament for 1,24 h of the observation group was significantly lower than that of the control group (P＜0.05).2 months after treatment,FMA score,FM score and GCS score in two groups was significantly improved(P＜0.05);FMA score,FM score and GCS score of the observation group was significantly higher than thatof the control group(P＜0.05)2 months after treatment.The adverse events ofnursing intervention in the observation group was significantly lower than that in the control group (11.54%vs. 50.00%,P＜0.05).Conclusion The early cluster treatment can effectively improve hemodynamic,motor function,awareness of multiple trauma patients with traumatic brain injury,reduce the incidence of adverse events,which can be widely used in clinical practice. 2017 Vol. 24 (8): 37-39 [Abstract] ( 150 ) HTML (41 KB)  PDF  (0 KB)  ( 33 ) 40 Effect comparison of single-port method and double-port thoracoscopic pulmonary bulla resection in the treatment of spontaneous pneumothorax XU Guang Objective To explore the advantages and disadvantages of single-port method and double-portthoracoscopic pulmonary bulla resection in the treatment of spontaneous pneumothorax.Methods From December 2009 to December 2015,88 patients with spontaneous pneumothorax in our hospital were divided into single-port group(treated by singleport resection,n=48)and double-port group (treated by double-port resection,n=40).Perioperative situation(operation time,blood loss,volume of drainage,drainage indwelling time,length of hospitalization,mortality rate and VAS pain score), complications rate and recurrence rates,patients′satisfaction were compared between two groups.Results Operation time between two groups had no statistical differences(P＞0.05).Blood loss,volume of drainage,drainage indwelling time,length of hospitalization and VAS pain score ofthe single-portgroup was lower than that of the double-port group (P＜0.05).There was no mortality and recurrent patients in two groups,there was 1 case of pulmonary leakage in each group,while the complications rate had no statistically difference(P＞0.05).But satisfaction rate of the single-port group was significantly higher than that of the double-port group(P＜0.05).Conclusion The method of single-port and double-port have the same therapeutic effect and prognosis effect.But the single-port method has smaller trauma,less pain,faster recovery,and higher patients′satisfaction rate,which is worth to be promoted. 2017 Vol. 24 (8): 40-42 [Abstract] ( 174 ) HTML (38 KB)  PDF  (0 KB)  ( 30 ) 43 A preliminary study of blood flow ultrasonography in carotid artery by unarmed and mechanical cardiopulmonary resuscitation DOU Lian-feng;FAN Guo-ai;YIN Zhi-yong;ZHANG Yan-zhen;TIAN Fei Objective To explore the characteristics and monitoring effect of blood flow ultrasonography in carotid artery during unarmed and mechanical cardiopulmonary resuscitation.Methods A total of 28 patients with cardiac arrest ad鄄mitted into our department of emergency from November 2015 to November 2016 were selected as research objects. They were evenly divided into unarmed cardiopulmonary resuscitation(CPR)group (n=14)and mechanical CPR group (n=14)in random.In the unarmed CPR group,unarmed chest compression for 30 minutes was used,while in the me鄄chanical CPR group,30-minute mechanical chest compression was adopted.The average of peak systolic velocity(PSV) in carotid artery and frequency of compression in each minute during the initial 5 minutes and the terminal 5 minutes were measured by Ultrasound Doppler technique.Results In the unarmed CPR group,the average PSV value in carotid artery during the initial 5 minutes was higher than that of the terminal 5 minutes with a statistical difference(P＜0.01). The achieved rate of compression frequency was also higher than that in the terminal 5 minutes(P＜0.05).In the me鄄chanical CPR group,the average PSV values in the initial 5 minutes,terminal 5 minutes,and achieved rate of compres鄄sion frequency were all higher than those in the unarmed CPR group with statistical differences(P＜0.01).The achieved rate of compression in the mechanical CPR was 100%.Conclusion Compared with unarmed CPR,the mechanical CPR can obtain a better carotid artery perfusion.Ultrasonography can realize the real-time feedback of compression frequen鄄cy and blood flow in carotid artery,and is used as a non-invasive CPR quality control. 2017 Vol. 24 (8): 43-46 [Abstract] ( 123 ) HTML (46 KB)  PDF  (0 KB)  ( 32 ) 47 The randomized,double blind and control study of Probiotics in the treatment of psoriasis vulgaris LU Xiu-yi Objective To investigate the randomized,double blind,and control study of Probiotics in the treatment of psoriasis vulgaris and to analyze the curative effect and application value of Probiotics in the clinical treatment of psoriasis vulgaris.Methods 50 patients with psoriasis vulgaris were treated in our hospital from June to October 2016 were evenly divided into two groups by random,double-blind,and comparison.The controlgroup(n=25)was used the Actretin Capsules for treatment,while on the basis of treatment in control group,the observation group(n=25)was accompanied it with Probiotics for treatment.The post-treatment clinical efficiency,skin lesion area before and after treatment,severity index scores(PASI)before and after the treatment were comprared after 3 months.Results The total effective rate in the observation group was 92%(23/25),which was significantly higher than that in the control group of 72%(18/25),with significant difference (P＜0.05).Before treatment,there was no significant difference in PASI score between two groups (P＞0.05),while after treatment,the PASI score of the observation group was (6.82±4.22)points,which was significantly lower than that of the control group (10.76±5.35)points,with significant difference (P＜0.05).Conclusion In the therapeutic process of psoriasis vulgaris,both the conventional treatment and Probiotics treatment can significantly improve the efficacy,and reduce the PASI score,it is worthy of promotion. 2017 Vol. 24 (8): 47-49 [Abstract] ( 189 ) HTML (35 KB)  PDF  (0 KB)  ( 40 ) 50 Effect analyzing of Clobetasol Propionate Cream combined with Epinastine Hydrochloride Capsules in the treatment of chronic eczema HUANG Xiu-ping;LI Fang-gu;CHEN Lei;LIN Ying-ping;LAO Fu-zhou Objective To explore the effect of Clobetasol Propionate Cream combined with Epinastine Hydrochloride Capsules in the treatment of chronic eczema.Methods 56 cases of chronic eczema patients in our hospital from February 2015 to February 2016 were selected and divided into the control group and the combined treatment group according to different treatment methods,28 cases in each group.The control group was treated with Qingpeng Ointment,the combined treatment group was given Clobetasonl Propionate Cream combined with Epinastine Hydrochloride Capsules. The clinical symptom score,total effective rate and adverse reactions were observed before and after treatment in the two groups.Results The clinical symptom scores of the two groups after treatment was lower than that before treatment, the clinical symptom score ofthe combined treatment group after treatmentwas lower than thatof the controlgroup after treatment,with significant difference(P＜0.05).The total effective rate of the combined treatment group was higher than that ofthe control group,with significantdifference(P＜0.05).The incidence rate ofadverse reactions in the combined treatment group was lower than that in the control group,with significant difference(P＜0.05).Conclusion The clinical effect of Clobetasol Propionate Cream combined with Epinastine Hydrochloride Capsules in the treatment of chronic eczema is obvious,it is worthy of clinical promotion and application. 2017 Vol. 24 (8): 50-52 [Abstract] ( 168 ) HTML (38 KB)  PDF  (0 KB)  ( 27 ) 53 Relationship between serum homocysteine and islet beta cell function in patients with Type 2 Diabetes Mellitus ZHA NG Si-qing;XI Yan-hua;ZHONG Shu-mei;GUO Jing-qin Objective To explore the relationship between serum homocysteine and islet beta cell function in patients with type 2 diabetes mellitus(T2DM).Methods 118 patients with T2DM in our department of Endocrinology from January 2014 to September 2016 were selected and divided into the T2DM with high serum homocysteine level group and the T2DM with normal serum homocysteine level group according to the level of serum homocysteine,oral glucose tolerance tests(OGTT)and insulin secretion tests were performed in the two groups.The clinical features of gender,age,duration,BMI,FBG,HbA1c,serum homocysteine were compared between the two groups,the steady-state model were used to evaluated the function index of islet beta cell,and which were compared between the two groups.Results There were no significantly differences in sex,age,BMI,duration and the level of FBG,FINS,HbA1c,HOMA-β,AUCI30-120/AUCG30-120between the two groups(P＞0.05).TheΔI30/ΔG30in the T2DM with high serum homocysteine level group was lower than that in the T2DM with normal serum homocysteine level group,with significant difference (P＜0.05).There were positive correlation between homocysteine and age (r=0.229,P=0.006).Conclusion T2DM with high serum homocysteine level may be related to age and the early phase insulin secrction were decreased more severly. 2017 Vol. 24 (8): 53-55 [Abstract] ( 188 ) HTML (38 KB)  PDF  (0 KB)  ( 33 ) 56 Clinical characteristics of different levels of serum TSH subclinical hypothyroidism in patients with type 2 diabetes mellitus and the influence of high serum TSH level on the patients LIU Cai-juan;HUA NG Xi-fan;YANG Jun-feng Objective To analyze the clinical characteristics of type 2 diabetes mellitus and subclinical hypothyroidism with different levels of serum thyrotropin (TSH),and to explore the influence of high serum TSH levels on patients. Methods 75 patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism who were diagnosed and treated in our hospital from May 2012 to May 2016 were selected as the observational group.75 patients with type 2 diabetes mellitus not complicated with subclinical hypothyroidism were selected as the control group at the same period.The clinical characteristics and their influence on complications were compared between the two groups.According to the level of thyrotropin,the patients were divided into the normal group (75 cases),the mildly elevated group(45 cases)and the markedly elevated group (30 cases).The complications of the three groups were compared.Results The level of thyroglobulin antibody (TgAb),thyroid peroxidase (TpoAb)and TSH in the observation group was higher than that in the control group,serum free triiodothyronine(FT3)level in the observation group was lower than that in the control group,with significant difference(P＜0.01).The levels of total cholesterol(CHOL)and low density lipoprotein(LDLC)in the observation group was higher than that in the control group,with significant difference (P＜0.01).There was no significant difference of the level of HDL-C,ApoB and ApoA1 between the two groups(P＞0.05).The incidence rate of complications in the patients with elevated thyrotropin level group was higher than that in the mildly elevated group and the normal group,with significant difference (P＜0.01).Conclusion The abnormal degree of laboratory indices and the incidence rate of complications in patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism are higher than those in healthy people.Therefore,prevention and treatment should be performed in the patients complicated with subclinical hypothyroidism,so as to prevent the occurrence of complications. 2017 Vol. 24 (8): 56-58转68 [Abstract] ( 149 ) HTML (39 KB)  PDF  (0 KB)  ( 36 ) 59 Efficacy analysis of three-dimensional conformal radiotherapy combined with transcatheter arterial infusion chemotherapy in treatment of highgrade malignant glioma TANG Tao;DING Chang-qing;SUN Zu-jie;ZHANG Chao Objective To evaluate the clinical efficacy of hree-dimensional conformal radiotherapy (3DcRT)combined with transcatheter arterial infusion chemotherapy in treatment of high-grade malignant glioma (HGG).Methods From March 2009 to February 2013,37 postoperative patients with HGG treated in our hospital confirmed by pathology were divided into two groups according to the random number table method.The control group (n=18;gradeⅢ in 8 cases, gradeⅣin 10 cases)only underwent 3DcRT,the combined treatment group (n=19;gradeⅢin 9 cases,gradeⅣin 10 cases)underwent 3DcRT combined with transcatheter arterial infusion chemotherapy.In the two groups.The combined treatment group was treated with ACNU[2.0 mg／(kg·time)]and VM-26(50 mg/time)for arterial chemoembolization.Single radiation quantity was 2.0 Gy/(time·d),five times per week,the radiotherapy dose(DT)was 50-56 Gy.The times and frequency of chemotherapy were determined according to the patient′s body and tumor situation.The short-term and longterm efficacy and adverse reaction in the two groups were obseved.Results Survival rate of 6,12,24,36 months after treatment in the control group was 77.78%,66.67%,50.00%,38.89%,22.22%respectively,and it was 89.47%,78.95%, 68.42%,52.63%,36.84%respectively in the combined treatment group,and there was a statistical difference between two groups(P＜0.05).The median survivaltime was 11.2 months in the controlgroup and thatwas 18.6 months in the combined treatment group,the differences were significant(χ2=8.76,P＜0.05).Conclusion 3DcRT combined with transcatheter arterial chemoembolization can significantly improve the survival rate and prolong the survival time of patients with HGG than radiotherap alone. 2017 Vol. 24 (8): 59-62 [Abstract] ( 151 ) HTML (48 KB)  PDF  (0 KB)  ( 35 ) 63 Clinical analysis of Shenqi Fuzheng Injection combined with TP regimen in the treatment of ovarian cancer YU Cong;FENG Xiao-li Objective To investigate the clinical effect of Shenqi Fuzheng Injection combined with TP regimen in the treatment of ovarian cancer.Methods From February 2013 to January 2016,clinical data of 50 patients with ovarian cancer treated in our hospital were retrospectively analyzed and patients were divided into the observation group(n=25) and the control group(n=25)according to clinical data of patients.Both groups were treated with Taxol and Platinum(TP regimen).On the basis,the observation group was treated with Shenqi Fuzheng Injection,intravenous drip of 250 ml Shenqi Fuzheng Injection,once a time,and 3 weeks was a cycle.The efficacy of treatment,quality of life(KPS)and the incidence of adverse reactions were compared between two groups.Results There was no significant difference in the total effective rate and disease control rate between the two groups(P＞0.05).The improvement rate of KPS score in the observation group was 96.0%while in the control group was 72.0%,and there was a statistical difference between two groups(P＜0.05).The incidence rate of leukopenia,hair loss,bone marrow suppression,vomiting and nausea,gastrointestinal reactions and other adverse reactions in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion The clinical effect of Shenqi Fuzheng Injection combined with TP regimen is significantin the treatment of ovarian cancer.It can significantly improve the quality of life of patients,reduce the adverse reactions caused by chemotherapy,and improve patients′tolerance to drugs,which has positive effect on the prognosis of patients,it is worthy of clinical prumotion an application. 2017 Vol. 24 (8): 63-65 [Abstract] ( 150 ) HTML (38 KB)  PDF  (0 KB)  ( 37 ) 66 Diagnostic value of HC2 and TCT in cervical cancer and precancerous lesion CHENG Xi-yun;YU Ying;WANG Dong-mei Objective To analyze the diagnostic value of high-risk human papillomavirus DNA (HC2-HPV-DNA)detected by two generation hybrid capture and thinprep cytology test(TCT)in cervical cancer and precancerous lesion. Methods From June 2014 to June 2016,342 patients with cervical lesion admitted into our hospital were selected.All patients were given TCT test,HC2 test,combined test,and pathological biopsy.TCT test was performed by the TBS grading system;HC2 test was performed by two generation hybrid capture.The combined test of two methods and pathological biopsy were carried out in the patients,and the test results were observed.Results According to the principle of cytological and histological diagnosis could differ by class 1,the coincidence rate of LSIL,HSIL,SCC of TCT detection result and final pathological diagnosis result was 50.0%,84.9%,and 100.0%,respectively.In addition,for different pathological diagnosis results,the positive rate of HC2 was also different.If the cervical lesions were more severe,the positive rate of HC2 test was higher,and the difference was statistically significant(P＜0.05).The sensitivity,specificity,accuracy, negative predictive value and positive predictive value for combined test of TCT+HC2 were higher than those of single detection.Conclusion Combined test detection of TCT+HC2 in the diagnosis of cervical cancer and precancerous lesion has a higher accuracy,which is worthy of clinical promotion and application. 2017 Vol. 24 (8): 66-68 [Abstract] ( 149 ) HTML (37 KB)  PDF  (0 KB)  ( 27 ) 69 Analysis of 86 cases of stage T1breast cancer treated with breast and axillary reservation operation SHI Li-bo;WANG Wei;YU De-hai;TIAN Hong-yu Objective The observe the therapeutic effect of breast and axillary reservation operation for stage T1breast cancer.Methods The clinicaldata of86 patients with stage T1breastcancer who underwentbreastand axillary reservation operation treated in our hospitalform August 2009 to October 2014 were retrospectively analysed.The postoperative complications,the effectofbreastaesthetics and the relationship between tumor size and prognosis were analyzed.Results Surgicalincision in 86 patients with stageⅠhealing,no limb lymphedema,postoperative satisfaction effects on aesthetics ofbreast was 96.5%(83/86).The tumor diameter less than 1 cm were 40 cases(group 1),the positive rate ofsentinellymph nodes was 0(0/40);tumordiametermore than 1 cm and less than 2 cm were 46 cases(group 2),the positive rate ofsentinellymph nodes was 15.2%(7/46).There was significant difference in the positive rate of sentinellymph node between two groups(P＜0.05). Further survival analysis showed that the survival rate of the group 1 was slightly higher than that of group 2,but the difference was not statistically significant(P＜0.05).All cases were followed up for 24-87 months,the median follow-up time of 50 months,and no recurrence and metastasis were found.Conclusion Breast and axillary reservation operation in the treatment of stage T1breast cancer has good effect and few complications,which is worthy of clinical application. 2017 Vol. 24 (8): 69-71转77 [Abstract] ( 158 ) HTML (44 KB)  PDF  (0 KB)  ( 40 ) 72 Effect of Bevacizumab combined with XELOX scheme in teatment of metastatic coloretal cancer HE Sheng-quan;LUO ying-chao;LAI Jia-jun;ZENG De-qiang;ZHANG Tao Objective To compare the clinical effect,safety and survival rate between Bevacizumab combined with XELOX(Capecitabine combined with Oxaliplatin)regimen and only XELOX regimen in treatment of metastatic coloretal cancer.Methods 55 patients with metastatic coloretal cancer treated in our hospital from January 2013 to June 2014 were selected and randomly divided into observation group (26 cases)and control group (29 cases).The observation group was treated with Bevacizumab combined with XELOX regimen while the control group with XELOX regimen only.The clinical effect,incidence rate of adverse reaction and survival rate between two groups were compared.Results The effective rate in observation group (26.92%)was higher than thatof 10.34%in control group,and the difference was statistically significant(P＜0.01).There was no statistic difference in incidence rate of adverse reaction,disease control rate and survival rate(P＞0.05).Conclusion Bevacizumab combined with XELOX regimen is safe,which can increase the clinicalefficacy treating metastatic coloretal cancer. 2017 Vol. 24 (8): 72-74 [Abstract] ( 177 ) HTML (39 KB)  PDF  (0 KB)  ( 39 ) 75 The significance of the thymidylate synthase expression in therapeutic effect evaluation of Pemetrexed treating patients with advanced ovarion cancer HU Yong-hua;FAN Yu-fei;QIN Yuan;LI Ding-gang Objective To evaluate the significance ofthe thymidylate synthase(TS)expression in therapeutic effect evaluation of Pemetrexed in patients with advanced ovarion cancer.Methods Eighty patients with advanced recurrent ovarian cancer from July 2010 to July 2014 treated in our hospital were analyzed retrospectively,all of them were treated by Pemetrexed combined with Nedaplatin,the experimental group had 40 cases,their tumor tissue were detected by immunohistochemistry with TS negative expression,the control groups of 40 cases with unknown TS expression.The therapeutic effectwas analyzed.Results In experimental group,there were 2 cases achieved complete responses(CR)of the 40 cases, 21 cases achieved partial response(PR),8 cases achieved stable disease(SD)and 9 patients with progressive disease(PD), while in observation group,there was 1 case achieved CR of the 40 cases,13 cases achieved PR,7 cases achieved SD and 19 patients with PD,while in experimental group,the overall response rate,the disease control rate and one year survival rate were 57.5%,77.5%and 60.0%respectively,in observation group,it was 35.0%,52.5%,37.5%respectively,and there was a statistical difference between two groups(P＜0.05).Conclusion TS expression may serve as an indicator to predict the sensitivity of chemosensitivity to Pemetrexed in patients with advanced ovarian cancer,the negative expression of TS can benefit from chemotherapy with Pemetrexed. 2017 Vol. 24 (8): 75-77 [Abstract] ( 141 ) HTML (36 KB)  PDF  (0 KB)  ( 36 ) 78 Screening results and significance of breast cancer and cervical cancer among women at appropriate age in Huangdao District of Qingdao City CHEN Dong-hong;LI Xiu-fen Objective To explore the screening results and significance of breast cancer and cervical cancer among women at appropriate age in Huangdao District of Qingdao City.Methods A total of 2000 women at appropriate age participating in free cervical cancer and breast cancer screening from January to December in 2016 were selected as research objects.All these participants were provided with regular breast cancer and cervical cancer examinations for free.The screening results were calculated.The prevalence of breast cancer and cervical cancer was analyzed.Detection of breast precancerous lesion,breast cancer,and cervicitis at different age groups including 36 to 50 years old and 51 to 64 years old were analyzed.Results There were 2000 women performed with hand touching on breasts,700 ones with mammary gland ultrasonography,and 315 with mammography.Among them,the number of BI-RADS 2,BI-RADS 3,BIRADS 4A,and BI-RADS 4C was 4,11,3,and 1 case,of which one person was diagnosed as breast malignant tumor.With regards to detection rates of breast precancerous lesion and breast cancer,there was no statistical difference between 36 to 50 years old and 51 to 64 years old (P＞0.05).All participants received with cervical smear,and the abnormal rate of cervical Papanicolaou (Pap)was 1.15% (23/2000).200 women were dealt with vaginoscopy,and 100 with pathological examination of cervical tissues.The cervical inflammation rate was 2.95%,and cervical malignant tumor was not detected.The positive detection rate of cervical Pap at 36 to 50 years old was 1.43%,ahich was much higher than that at 51 to 64 years old accounting for 0.84%,with a statistical difference (P＜0.05).The detection rate of cervical inflammation at 36 to 50 years old was 3.93%,which was significantly higher than that at 51 to 64 years old,which was displayed a statistical difference.No breast precancerous lesion was detected in the screening of breast cancer and cervical cancer. Conclusion Implementation of breast cancer and cervical cancer screening at women appropriate age in Huangdao District of Qingdao City is satisfactory.It can effectively detect breast cancer and cervical cancer,and is beneficial to early treatment and prognosis improvement. 2017 Vol. 24 (8): 78-80 [Abstract] ( 147 ) HTML (37 KB)  PDF  (0 KB)  ( 30 ) 81 Analysis of the application of pregnancy plasma D-dimer testing in the diagnosis of pregnancy-induced hypertension syndrome ZHAO Li-min;LI Xia-ying;LI Shi-rong;LI Wen-zhu Objective To study the application value of plasma D-dimer testing in diagnosis of pregnancy-induced hypertension syndrome.Methods From February 2015 to December 2016,in our hospital for prenatal diagnosis,delivery and hypertension syndrome,300 cases of pregnant women were selected as observation group,in the same period 300 cases of normal pregnant women were selected as pregnancy group,at the same time taken the same period of women health check-up 300 cases were selected as control group.Levels of plasma D-dimer were compared between the three groups. In addition,pregnant women of the observation group were divided into mild group(124 cases),moderate group(86 cases)and severe group(90 cases)according to the illness severity,levels ofplasma D-dimer were compared among the three groups,and the correlation between plasma D-dimer level and severity of pregnancy-induced hypertension syndrome was analyzed by Spearman correlation coefficient.Results The levelofD-dimer in the observation group was(0.83±0.52)mg/L, significantly higher than that of the pregnancy group and the control group[(0.39±0.17),(0.17±0.09)mg/L],and the normalpregnancy group was significantly higher than that of the control group,the differences were statistically significant (P＜0.05).Levelof D-dimer in the mild group[(0.52±0.22)mg/L],was significantly lower than thatin the moderate group[(0.78± 0.21)mg/L]and the severe group[(1.19±0.66)mg/L],and level of D-dimer in the moderate group was lowerthan thatin the severe group,the differences were statistically significant(P＜0.05).By the Spearman correlation analysis,plasma D-dimer level and severity of pregnancy-induced hypertension syndrome was significantly positive correlation(r=0.745,P＜0.01). Conclusion Through clinical examination level of plasma D-dimer pregnancy-induced hypertension syndrome can be effectively diagnosed,and clinical diagnosis value is higher. 2017 Vol. 24 (8): 81-83 [Abstract] ( 160 ) HTML (35 KB)  PDF  (0 KB)  ( 39 ) 84 Analysis of the curative effect in different gestational ages premature infants with PDA by oral Ibuprofen ZHANG Ke-gang;LI Jie;SUN Bo;WU Jing-cai Objective To explore the curative effect of oral Ibuprofen in different gestational ages (GA)premature infants with patent ductus arteriosus(PDA).Methods The premature infants of gestational age＜37 weeks for 2427 cases were examined by Doppler ultrasound in our hospital from November 2013 to October 2016,and they were divided into ten groups by differentgestationalages:15 cases＜28 weeks,43 cases of28 weeks,81 cases of29 weeks,156 cases of30 weeks, 267 cases of 31 weeks,336 cases of 32 weeks,359 cases of 33 weeks,457 cases of 34 weeks,371 cases of 35 weeks, 342 cases of 36 weeks,and each premature infant with a hemodynamically significant patent ductus arteriosus(hsPDA) was treated by oral Ibuprofen.The course of treatment was 3 days.They were given Ibuprofen 10 mg/kg,then Ibuprofen 5 mg/kg after 24 and 48 hours,and they were examined by Doppler ultrasound when one or two days after the treatment. The rate ofartery catheter closure was counted,and the side effects ofIbuprofen was observed.Results There were 203 infants with hsPDA in 2427 premature infants.The closure rate ofeach group was 63.6%in less than 28 weeks,71.4%in 28 weeks, 74.1%in 29 weeks,77.1%in 30 weeks,80.4%in 31 weeks,82.1%in 32 weeks,89.5%in 33 weeks,92.3%in 34 weeks, 100.0%in 35 weeks,100.0%in 36 weeks.There were 17 cases with adverse reactions,including 4 cases ofgastrointestinal bleeding,7 cases of gastric retention,2 cases of abdominal distension and 4 cases of oliguria.Conclusion In the treatment of PDA premature infants with different gestational age,Ibuprofen has the characteristic of the smaller of the gestational age,the lower closure rate of PDA,and the adverse reactions of Ibuprofen is easy to be observed and treated, it is worthy of clinical application. 2017 Vol. 24 (8): 84-86 [Abstract] ( 178 ) HTML (31 KB)  PDF  (0 KB)  ( 38 ) 87 Effect comparison of hysteroscopy and abdominal ultrasonography in the diagnosis of endometrial lesions GENG Yun-xia Objective To explore the effect of hysteroscopy and abdominal ultrasonography in the diagnosis of endometrial lesions.Methods Seventy patients probably suspected with endometriosis who were admitted to our hospital from February 2010 to June 2015 were enrolled in this study.All patients were performed with abdominal B-ultrasonography, hysteroscopy,and histopathological examination.The diagnosis of B-ultrasonography,hysteroscopy and pathology was observed;the sensitivity and specificity of B-ultrasonography and hysteroscopy,coincidence rate with the pathological diagnosis were observed.Results Among the 70 patients,there were 66 cases in abnormal diagnosis by histopathology and 4 cases in normal.By the abdominal B-ultrasonography,the number of abnormal and normalcases was 62 and 8 respectively.There were 65 cases in abnormal diagnosis and 5 cases in normal by hysteroscopy.The sensitivity and specificity by hysteroscopical diagnosis were both higher than those by the abdominal B-ultrasonography;the coincidence rates of endometrial polyps,birth control ring incarceration,uterine adhesions,secondary or primary infertility,uterine submucous myoma,and normal endometrial diagnosed by hysteroscope and the total coincidence rate with the pathological diagnosis were both higher in comparison with those by the abdominal B-ultrasonography,the differences were statistically significant(P＜0.05).Conclusion Hysteroscopy is more accurate in the diagnosis of endometrial lesions than abdominal B-ultrasound,which is more beneficial for the condition evaluation and subsequent symptomatic treatment of patients,it is proposed for promotion and application in clinic. 2017 Vol. 24 (8): 87-89 [Abstract] ( 140 ) HTML (38 KB)  PDF  (0 KB)  ( 32 ) 90 Clinical effect of intermittently taking iron dextran oral liquid on pediatric nutritionaliron deficiency anemia TANG Ying;WU Na;WANG Huan;FAN Zhen;ZHANG Ding-ping Objective To explore the application effect of intermittently taking iron dextran oral liquid (IDOL)on pediatric nutritional iron deficiency(NIDA)therapy.Methods 300 cases of NIDA children who were admitted into our hospital from October 2012 to May 2016 were selected and divided into experiment group(150 cases)which treated with IDOL intermittently and control group(150 cases)which treated with IDOL continuously.After six weeks,the clinical effects,adverse reaction and the levels of hemoglobin,serum iron and reticulocyte of patients between two groups were compared.Results Aftertreatment,the incidence ofexperimentalgroup(98.2%)was higherthan thatofcontrolgroup(88.0%), the incidence of adverse reaction(12.7%)was lower than that of control group(44.7%),and the difference was statistically significant(P＜0.05).The levels of hemoglobin,serum iron and reticulocyte of patients in two groups were all improved after treatment,and the levels of hemoglobin,serum iron were higher than those in control group,and the difference was statistically significant(P＜0.05).The treatment cost in experiment group[(260.00±27.00)Yuan]was lower than in control group[(102.00±11.00)Yuan],and the difference was statistically significant(P＜0.01).Conclusion Intermittently take IDOL has a good effect and less adverse reaction on pediatric NIDA,and it is worth to be recommanded in clinic. 2017 Vol. 24 (8): 90-92 [Abstract] ( 154 ) HTML (40 KB)  PDF  (0 KB)  ( 35 ) 93 Effect of vaginal microflora on adverse pregnancy outcomes in late pregnancy TONG Yu;SHAO Xiao-guang Objective To explore the effect of vaginal microflora on adverse pregnancy outcomes in late pregnancy. Methods 220 cases of pregnant woman who took prenatal examination in our hospital from January to June 2016 in late pregnancy were selected,then vaginalfluid were collected and detected pH,hydroge(H2O2),leucocyte esteraseand sialidase,and vaginal microflora were evaluated,effect of vaginal microflora to vaginal pH were observed,all pregnant woman were followed up,and effect of vaginal microflora to adverse pregnancy outcomes(premature rupture of membranes,premature delivery,intrauterine asphyxia,low birth weightinfant,puerperal infection)were observed.Results Among the 220 late pregnants,152 cases(69.1%)were normal in vaginal microflora(microflora normal group);54 cases(24.5%)were vaginal micro-ecologicalimbalance(microflora imbalance group);14 cases(6.3%)were bacterialvaginosis(bacterialvaginosis group). Vaginal pH in microflora imbalance group and bacterial vaginosis group was higher than that in microflora normal group;vaginal pH in bacterial vaginosis group was higher than that in microflora imbalance group,and the differences were statistically significant(P＜0.01).The incidence of premature rupture of membranes,intrauterine asphyxia,premature delivery,low birth weight infant in microflora imbalance group and bacterial vaginosis group were higher than those in microflora normal group,and those in bacterial vaginosis group were higher than those in microflora imbalance group;the incidence of puerperal infection in bacterial vaginosis group was higher than that in microflora imbalance group and microflora normal group,and all the differences were statistically significant(P＜0.05).Conclusion Vaginal microflora has obvious effect in pregnancy outcomes,it is a reason of adverse pregnancy outcomes,prenatal examination care shoud pay attention to maintaining vaginal microflora healthy. 2017 Vol. 24 (8): 93-95 [Abstract] ( 147 ) HTML (39 KB)  PDF  (0 KB)  ( 40 ) 96 Efficacy analysis of uterine artery interventional treatment in uterine incision pregnancy LIU Shu-fang Objective To explore the efficacy of uterine artery interventional treatment in uterine incision pregnancy. Methods 134 patients with uterine incision pregnancy in our hospital from December 2013 to December 2015 were selected and divided into two groups according to random number table method with 67 cases in each group.Patients in the control group received methotrexate lesion intervention.Patients in the observation group received uterine artery intervention+curettage.The clinical indexes before and after treatment,treatment effect and complications were compared between two groups.Results After treatment,the levels of serumβ-HCG and progesterone of patients in two groups were decreased,and those in the observation group [(143.7±21.5)U/L,(5.8±0.6)nmol/L]were lower than those in the control group[(271.9±34.8)U/L,(7.1±1.0)nmol/L];the amount of bleeding during operation[(68.5±7.1)ml]and hospital costs [(14 502.6±1137.9)Yuan]in the observation group were less than those in the control group [(189.2±10.3)ml,(16 387.2±1305.4)Yuan].The time of hospitalization,serum β-HCG,progesterone and menstruation returning to normal [(11.7±1.6),10.7±1.2),(5.7±1.3),(52.6±4.3)d]in the observation group were shorter than those in the control group [(15.3±2.1),(13.6±1.4),(7.9±1.1),(70.8±5.9)d];the incidence of complications in the observation group (3.0%)was lower than that in the control group(11.9%),and all the differences were statistically significant(P＜0.05).Conclusion Uterine artery interventional treatment has significant effect in uterine incision pregnancy,which has the advantages of small wound,fast recovery,economy,safety and so on.It is worthy of clinical application. 2017 Vol. 24 (8): 96-98 [Abstract] ( 118 ) HTML (39 KB)  PDF  (0 KB)  ( 34 ) 99 Clinical efficacy of different dose of gamma globulin in children with Kawasaki Disease HUANG Wang-bin;OU Qiu-yan;LIN Dong-li Objective To explore the clinical efficacy of different dose of gammag lobulin in children with Kawasaki disease(KD).Methods Forty children with KD from February 2014 to December 2015 were selected and randomly divided into the control group and the observation group,with 20 cases in each group.The control group was treated with lowdose gamma globulin,while the observation group was treated with high dose gammag lobulin.The time of fever clearance and hospitalization,the incidence of coronary artery lesions,and the levels of C-reactionprotein(CRP)and procalcitonin(PCT)before and after treatment of children in two groups were compared.Results The time of fever clearance and hospitalization of children in the observation group[(21.37±2.85)h,(3.24±0.89)d]were shorter than those in the control group[(33.09±3.17)h,(4.98±1.15)d],the differences were statistically significant(P＜0.05);the incidence of coronary artery lesions after 1 year follow-up in the observation group(5.00%)was lower than that in the control group(30.00%),the difference was statistically significant(P＜0.05).After treatment,the levels of CPR and PCT of children in two groups were decreased,comnpared with those before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The application of high dose of gamma globulin has significant effect in children with KD,which can shorten the time of fever clearance and hospitalization,reduce coronary artery lesions and decrease the levels of CRP and PCT of children.It is worthy of clinical application. 2017 Vol. 24 (8): 99-101 [Abstract] ( 125 ) HTML (36 KB)  PDF  (0 KB)  ( 29 ) 102 Clinical application and observation of new labor standards in the second stage of labor HUANG Li-chuan Objective To observe and compare the advantages and disadvantages of clinical application of a new and old labor standards in the second stage of labor,and to further verify the applicability of the new labor standard in clinical. Methods 50 primiparas with age of 22-30 years old,the head position and the normal measurement of the pelvis,the estimated fetal weight less than 4000 g from January 2012 to January 2014 in our hospital were selected as control group, the second stage of labor(more than 2 h)was diagnosed as prolonged second stage of labor according to the old labor standards;50 primiparas(selection criteria as above mentioned)from July 2015 to June 2016 of our hospital were selected as observation group,the second stage of labor(more than 3 h)was diagnosed as prolonged second stage of labor according to the new labor standards.The difference of the tate of cesarean section,vaginal delivery rate,postpartum hemorrhage and neonatal severe asphyxia in two groups were compared.Results The rate of cesarean section in the observation group was significantly lower than that in the control group,and the rate of vaginal birth in the observation group was significantly higherthan thatin the controlgroup,the difference was statistically significant(P＜0.05).There was no significant difference in the rate of postpartum hemorrhage and neonatal severe asphyxia between the two groups(P＞0.05). Conclusion The application of the new labor standard reduces the rate of cesarean section,increases the rate of vaginal delivery,and does not increase the incidence of postpartum hemorrhage and mild and severe neonatal asphyxia. 2017 Vol. 24 (8): 102-104 [Abstract] ( 154 ) HTML (33 KB)  PDF  (0 KB)  ( 35 ) 105 Hemostatic effect of Oxytocin combined with Shenghuatang Pills in patients with bleeding after drug abortion LIANG Shi-ying Objective To study the hemostatic effect of Oxytocin combined with Shenghuatang Pills in patients with bleeding after drug abortion.Methods A total of 90 patients undergone drug abortion from October 2015 to October 2016 in our station were selected.By a random number table,they were divided into control group and observation group,with 45 cases in each group.The Mifepristone and Misoprostol for termination of pregnancy were used in both groups.Besides,Oxytocin in the control group was selected to stanch bleeding,while in the observation group,combination of Oxytocin and Shenghuatang Pills was adopted.The hemostatic effectin both groups was compared.Results The amount of vaginal bleeding in the observation group was mainly equal to or less than that in the menstrual period,while the amount of bleeding was more than or equal to that in the menstrual period in the control group,the amount of vaginal bleeding in the two groups had statistically significantdifference(P＜0.05).In the observation group,number ofpatients with bleeding time less than 1 week was significantly larger than that in the control group(P＜0.05).The therapeutic effective rate in the observation group was 97.78%,significantly higher than that of the control group(80.00%)(P＜0.01).Conclusion The combination of Shenghuatang Pills and Oxytocin obtains a great effect on stanching bleeding after drug abortion,which can significantly reduce the amount of bleeding,shorten the bleeding time at advantages of good curative effect and practicality,and is worth of wide recommendation in clinic. 2017 Vol. 24 (8): 105-106转109 [Abstract] ( 115 ) HTML (37 KB)  PDF  (0 KB)  ( 37 ) 107 Prevention and treatment effect of intrauterine implantation Misoprostol in postpartum hemorrhage of pregnancy induced hypertension syndrome XU Fu-yan Objective To study the prevention and treatment effect of intrauterine implantation Misoprostol in postpartum hemorrhage of pregnancy induced hypertension syndrome.Methods 100 patients with postpartum hemorrhage of pregnancy induced hypertension syndrome from October 2015 to November 2016 treated by our hospital were selected. Patients were divided into observation group(50 cases)and control group(50 cases)according to treatment method.The control group was used Oxytocin and the observation group was used Misoprostol.After treatment,the total effective rate, incidence rate of total adverse effect and postpartum hemorrhage(intrapartum,postpartum 12 h and postpartum 24 h)of patients in two groups were observed.Results The total effective rate in observation group(96.00%)was obviously higher than that was 60.00%in control group;the incidence rate of adverse effect in observation group (4.00%)was lower than that was 14.00%in control group;the postpartum hemorrhage in observation group was respectively (15.22±7.25) ml at intrapartum,(32.21±16.12)ml at postpartum 12 h and (76.15±42.15)ml at postpartum 24 h,and they were less than those in control group[(45.15±21.45),(66.23±37.56)ml and(125.55±66.35)ml respectively](P＜0.05).Conclusion The effect of intrauterine implantation Misoprostol in postpartum hemorrhage of pregnancy induced hypertension syndrome is obvious,which can effectively reduce the incidence rate of adverse reaction,reduce the amount of postpartum hemorrhage and is worth to popularize in clinic. 2017 Vol. 24 (8): 107-109 [Abstract] ( 139 ) HTML (35 KB)  PDF  (0 KB)  ( 38 ) 110 Effect observation of bronchoalveolar lavage with bronchofibroscope in the treatment of children with lobar pneumonia CHEN Qiang Objective To explore the clinicaleffect of bronchoalveolar lavage(BAL)with bronchofibroscope(BFS)in the treatment of children with lobar pneumonia.Methods 80 children with lobar pneumonia in our hospital from August 2015 to November 2016 were selected and divided into the observation group and the control group by random number table method,40 cases in each geoup.The control group was treated with anti-infection,relieving cough and reducing sputum,abatement of fever,the observation group was given BAL with BFS on the basis of the control group.The clinical effects,fever clearance time,cough alleviation time,antibiotics consumption time,extinction time of lung rale,hospital stays and occurrence of complications of the two groups were compared.Results The curative total effective rate of the observation group was 95.00%,which was higher than that of the control group(77.50%),with significant difference(P＜0.05).The fever clearance time,cough alleviation time,antibiotics consumption time,extinction time of lung rale and hospital stays of the observation group was shorter than that of the control group,with significant difference (P＜0.05).The incidence rate of complications of the observation group was lower than that of the control group,with significant difference(P＜0.05).Conclusion The effect of BAL with BFS in the treatment of children with lobar pneumonia is significant, it can effectively increase clinical efficacy,shorten treatment time,reduce the incidence of complications and have higher safety,which has higher promotional value in clinical application. 2017 Vol. 24 (8): 110-112 [Abstract] ( 165 ) HTML (38 KB)  PDF  (0 KB)  ( 30 ) 113 Influence of different doses of Mifepristone on fibroid sizes in perimenopausal patients with uterine fibroids ZOU Min;LIU Yuan-xiang Objective To explore the influence of different doses of Mifepristone on the fibroid sizes in perimenopausal patients with uterine fibroids.Methods A total of 60 perimenopausal patients with uterine fibroids treated in our hospital from February 2015 to February 2016 were selected.They were evenly divided into the observation group and the controlgroup in random,30 cases in each group.In the control group,25 mg Mifepristone for oral administration once per day was provided,while in the observation group,half dose of Mifepristone in the control group was used once per day. The course of treatment was lasted for 6 months.The clinical curative effect,the changes of fibroid sizes,the level of estradiol(E2)and progesterone(P),the incidence rate of adverse reactions were compared between the two groups.Results The total clinical effective rate in the observation group was 96.67%,and 90.00%in the control group,there was no significant difference between the two groups(P＞0.05).Compared with before treatment,the sizes of uterus and uterine fibroids after treatment in the two groups were both significantly reduced,with significant differences(P＜0.05).However,there was no significant difference in the sizes of uterus and uterine fibroids after treatment between the two groups (P＞0.05).The total incidence rate of adverse reactions like nausea,vomiting,and profuse sweating was 13.33%, which was lower than that in the control group accounting for 30.00%,with significant difference(P＜0.05).The levels of E2and P after treatment in the two groups was lower than thatbefore treatment,with significantdifferences(P＜0.05).There was no significant difference in the levelof E2and P after treatmentbetween the two groups(P＞0.05).Conclusion Compared with conventional dose,the effect on perimenopausal uterine fibroids treated by low-dose Mifepristone is optimal with a lower incidence of adverse reactions and higher safety,which is worthy of clinical application and promotion. 2017 Vol. 24 (8): 113-115 [Abstract] ( 125 ) HTML (42 KB)  PDF  (0 KB)  ( 32 ) 116 Effect observation of 4 different methods for preventing dental caries in deciduous molars GE Feng-hua;CHEN Qi-qin;XI Xiao-ying;ZHANG Guo-ming;LIU Chun-zi Objective To investigate the clinical effect of 4 different methods for preventing dental caries in deciduous molars.Methods 160 cases of children aged 3-5 years in this district(Baoan District of Shenzhen City)from January to June in 2015 were selected as the research objects and divided into four groups with 40 cases in each group according to the different preventing decay methods.Children in group A used fluoride toothpaste to brush their teeth,children in group B used fluoride toothpaste to brush their teeth and their teeth were coated with fluoride protection paint,children in group C used fluoride toothpaste to brush their teeth and their teeth were coated with liquid resin pit and fissure sealant,children in group D used fluoride toothpaste to brush their teeth and their teeth were coated with fluoride protection paint and liquid resin pit and fissure sealant.The caries status of children in 4 groups 6,12,18 months after intervention were observed.Results In group A,the caries prevalence rates of primary molars was respectively 5.00%, 15.00%and 40.00%when 6,12,18 months after intervention,which was 5.00%,25.00%12,18 months after intervention in group B,with 10.00%12 months and 25.00%18 months after intervention in group C,and with 10.00%18 months after intervention in group D.The incidence of dental caries in group A 18 months after intervention was significantly higher than that of group B,group C or group D,the incidence of dental caries in group D was the lowest and there were statistically significant differences(P＜0.05).The incidence of adjacent caries showed that no caries occurred in 4 groups at the end of 6,12 months intervention.The incidence of adjacent caries in group A was 15.00%18 months after intervention,10.00%in both group B and C and there was no adjacent caries in group D.There was significant differences between group D and group A,group B, group C (P＜0.05).The caries showed in 4 groups6,12,18 mo nths after intervention that the caries in group B,group C or group D 18 months after intervention was significantly lower than that in A group,and the difference was statistically significant(P＜0.05).Conclusion The effect of only using toothpaste with fluoride to prevent the deciduous molar caries is the worst and the effect of using fluoride toothpaste brush with fluid resin pit closed and fluoride protective paint is the best.Fluoride varnish has a protective effect of pit and fissure sealant and also can prevent blocking off,which has significant preventive effect on deciduous molar caries. 2017 Vol. 24 (8): 116-118转124 [Abstract] ( 156 ) HTML (47 KB)  PDF  (0 KB)  ( 36 ) 119 Clinical effect of otic endoscope in the treatment of external auditory canal cholesteatoma FANG Xiao-min Objective To discuss the effect of otic endoscope in the treatment of external auditory canal cholesteatoma (EACC).Methods 40 patients with EACC in Department of E.N.T of People′s Hospital of Puning City form March 2014 to May 2016 were divided into observation group(n=20)and control group(n=20)by random number table method,the observation group were treated with otic endoscope,the control group were treated with traditional surgical,the curative effect and recurrence rate were compared between two groups.Results The effective rate was 100%in the observation group,significantly higher than 80%in the control group(P＜0.05).The recurrence rate was 5%in the observation group, significantly lower than 15%in the control group (P＜0.01).Conclusion Effects of otic endoscope in the treatment of EACC was significant,which has lower recurrence rate and easy to accept. 2017 Vol. 24 (8): 119-121 [Abstract] ( 131 ) HTML (35 KB)  PDF  (0 KB)  ( 41 ) 122 Effect comparison of Minocycline Hydrochloride Ointment and Iodine Glycerin in the treatment of acute pericoronitis CHEN Gui-rong;LUO Qun-di Objective To explore the clinical effect difference of Minocycline Hydrochloride Ointment and Iodine Glycerin in the treatment of acute pericoronitis.Methods 98 patients with acute pericoronitis who were treated in our hospital from January 2015 to June 2016 were chosed and divided into control group (n=49)and observation group (n=49) according to the parity of ID number.The control group was given Iodine Glycerin,the observation group was given Minocycline Hydrochloride Ointment.The therapeutic efficiency rate and change of flora in pericoronitis before and after treatment were compared between two groups.Results All the patients completed treatment,in the comparison of therapeutic effects,the therapeutic efficiency rate（93.9%）after treatment in the observation group was significantly better than that in the control group（79.6%）(P＜0.05);in the comparison of changes of flora,the bacteria density,G-proportion, spirochete proportion in the observation group was significantly lower than that in the control group,and G+proportion was higher(P＜0.05).Conclusion Minocycline Hydrochloride Ointment is effective for acute pericoronitis patients,with more effective control of inflammation infection and better treatment effect than Iodine Glycerin,which is worthy of a further application in clinical treatment. 2017 Vol. 24 (8): 122-124 [Abstract] ( 115 ) HTML (40 KB)  PDF  (0 KB)  ( 36 ) 125 Clinical application comparison of low-temperature radiofrequency ablation under laryngostroboscope and traditional laryngoscope in the treatment of epiglottic cyst CHENG Bing-wen;HU Li-qun;XU Ping-mei Objective To compare the clinical efficacy of low-temperature radiofrequency ablation under laryngostroboscope and traditional laryngoscope in the treatment of epiglottic cyst.Methods 90 patients with epiglottic cyst admitted into our hospital from April 2015 to June 2016 were selected as research object and randomly divided into two groups, 45 cases in each group.Control group took traditional laryngoscope,while observation group took low-temperature radiofrequency ablation under laryngostroboscope.The surgery situation,epiglottic cyst score,incidence of complications and recurrence of two groups were compared.Results The surgery time,intra-operative bleeding volume and postoperative recovery time of the observation group was lower than that of the control group (P＜0.05).There was no significant difference in the epiglottic cyst score between two groups before surgery(P＞0.05);the epiglottic cyst score of the observation group was significantly lower than that of the control group after surgery(P＜0.05).There was no significant difference in the incidence of complications and recurrence rate between two groups(P＞0.05).Conclusion Compared with traditional laryngoscope,low-temperature radiofrequency ablation under laryngostroboscope has quick postoperative healing,less complications,low recurrence rate,smaller tissue damage,which is worthy of generalization in clinical application. 2017 Vol. 24 (8): 125-127 [Abstract] ( 145 ) HTML (36 KB)  PDF  (0 KB)  ( 42 ) 128 Analgesic effect of different concentrations of Ropivacaine in post-delivery parturients QIU Yang;GUO Ying-liang Objective To analyze the epidural anesthesia effect of application of different concentrations of Ropivacaine in cesarean section after labor analgesia.Methods Altogether 90 cases of parturients who were hospitalized in our hospital from February 2015 to May 2016 were involved as the object of this research and randomly divided into group A and group B according to the even and odd number.45 cases in group A were administered with 0.75%Ropivacaine, while 45 cases in group B were administered with 1.00%Ropivacaine.The analgesic effect,motor nerve block and sensory block onset time of two groups were compared,and the occurrence of adverse reactions were analyzed.Results The skin incision analgesia scores and intraoperative analgesia scores of parturients in group B was(0.42±0.17),(0.34±0.06) scores,lower than that in group A[(0.93±0.25),(0.79±0.41)scores](P＜0.05);the modified Bromage scores of two groups had no statistically significant difference(P＞0.05);sensory block onset time of group B was(4.34±1.86)min,shorter than that ofgroup A[(5.12±1.43)min](P＜0.05).The incidence of adverse reactions ofgroup B was 20.00%,significantly higher than that of group A(4.44%),with statistically significant difference(P＜0.05).Conclusion Application of 0.75%Ropivacaine in epidural analgesia for parturients with cesarean section after labor analgesia can achieve considerable effect. 2017 Vol. 24 (8): 128-130 [Abstract] ( 149 ) HTML (38 KB)  PDF  (0 KB)  ( 31 ) 131 Effects of Ropivacaine combined with Methylprednisolone on brachial plexus block LIU Cai-tang;LI Xue-ping;LIU Hui-qin;ZHOU Li-li;CHEN Xiao-ling;LI Jian-wen;TIAN Ke-jing;WANG Guo-sheng Objective To explore the effects and safety of brachial plexus block(BPB)with Ropivacaine combined with Methylprednisolone.Methods 200 patients undergoing operation below shoulder level in our hospital from June 2015 to May 2016 were randomly divide into observation group (0.33%Ropivacaine 30 ml+Methylprednisolone 40 mg)and control group (0.33%Ropivacaine 30 ml)with 100 cases in each group according to the random number table method, two groups were guided to the BPB by the nerve stimulator.The sensory and motor block onset time,duration time of anesthesia,and complications were compared.Results Sensory and motor block onset time of the observation group was (10.2±3.8),(13.7±3.9)min,shorter than that of the control group [(14.4±3.1),(18.1±3.4)min](P＜0.05);duration time of sensory block and motor block of the observation group was (825.2±61.3),(733.5±77.1)min respectively,longer than that of the control group[(691.3±56.3),(566.9±78.3)min](P＜0.05);the observation group had 2 cases ofbradycardia,the control group was obsererved 4 cases of bradycardia and 4 cases of dizziness,the incidence of adverse reaction of the observation group(2.0%)was lower than that of the control group(8.0%)(P＜0.05).Conclusion Ropivacaine combined with Methylprednisolone for BPB shortens the sensory and motor block onset time,prolongs the duration time of anesthesia,and improves the safety of anesthesia. 2017 Vol. 24 (8): 131-133 [Abstract] ( 134 ) HTML (36 KB)  PDF  (0 KB)  ( 35 ) 134 Effects of Dezocine in different ways of administration on extubation and analgesia and sedation during recovery period after Remifentanil combined anesthesia therapy YUAN Zong-bao;MIAO Ming-hui Objective To study the effect of two different methods of administration by intramuscular injection and intravenous injection of Dezocine on Remifentanil combined anesthesia therapy.Methods 94 patients undergoing elective surgery with Remifentanil anesthesia and treated in Liaoning Maternal and Child Health Care Hospital from January 2015 to November 2016 were selected as research objects and divided into intramuscular injection group and intravenous injection group according to the random number method,47 cases in each group.Patients in two groups was respectively given 0.2 mg/kg of Dezocine by intramuscular injection or intravenous injection 30 minutes before the end of surgery.VAS scores and sedation scores at different time points,the recovery time,extubation time and respiratory recovery time,the incidence of hypotension,the use rate of Propofol and the satisfaction rate of patients were compared between two groups.Results The VAS scores of 1 hour and 2 hours when recovery in two groups was significantly higher than that when recovery (P＜0.05).However,there was no significant difference in the VAS scores between 4 hours after recovery and at the time when patients woke up (P＞0.05).The sedation scores of 1 hour and 2 hours after recovery were higher than that when recovery,but there was no significant difference (P＞0.05).There were significant differences in VAS scores and sedation scores at same time points between intramuscular injection group and intravenous injection group(P＜0.05).The recovery time,extubation time and respiratory recovery time after operation in the intramuscularinjection group was significant shorter than thatin the intravenous injection group(P＜0.05).The incidence rate of adverse reaction and the use rate of Propofol in the intramuscular injection group was significantly lower than that in the intravenous injection group (P＜0.05).The satisfaction rate of patients in the intramuscular injection group was significantly higher than thatin the intravenous injection group(P＜0.05).Conclusion Dezocine can effectively relieve the restlessness and pain of patients undergoing Remifentanil combined anesthesia,and the effect of intramuscular injection is better.At the same time intramuscular injection can also help to reduce adverse reactions and the number of analgesic drugs. 2017 Vol. 24 (8): 134-137 [Abstract] ( 122 ) HTML (44 KB)  PDF  (0 KB)  ( 30 ) 138 Effect of Methimazole combining with Quetiapine in treatment of mental disorders caused by thyroid function hyperfunction ZHANG Guang-biao;YAO Su-hua;ZENG Xue-mei Objective To investigate the effect of Methimazole combining with Quetiapine in treatment of mental disorders caused by thyroid function hyperfunction.Methods 100 cases of mental disorders caused by hyperthyroidism in our hospital from June 2015 to January 2016 were selected and randomly divided into study group and control group,50 cases in each group,the study group was given Methiramazole and Quetiapine,the control group was given Methiramazole.The thyroid function and neurological status were compared between two groups.Results The level of thyroid function of two groups were improved after treatment,the levels of FT3,FT4,TSH and BPRS in study group was significantly better than those in the control group after 2,4 and 6 weeks for treatment,and the levels of BPRS was lower than that in control group,the difference was significant(P＜0.05).Conclusion The combination of Methimazole and Quetiapine in the treatment of mental disorders caused by hyperthyroidism can effectively improve the thyroid function and the mental state of the patients,the effect is significant and it is worthy of popularization and application. 2017 Vol. 24 (8): 138-140 [Abstract] ( 123 ) HTML (38 KB)  PDF  (0 KB)  ( 44 ) 141 Effect analysis of Bushen Antai Decoction combined with Progesterone Capsules in the treatment of threatened miscarriage XIAO Shan;ZENG Qing;LIU Yan-qing Objective To analyze the clinical efficacy of Bushen Antai Decoction combined with Progesterone Capsules in the treatment of threatened abortion.Methods A total of 72 patients with threatened abortion treated in our hospital from January to July in 2016 were selected as object of study and divided into research group and control group according to the dynamic randomization,36 cases in each group.The patients in the control group were treated with Progesterone Capsules,and in the research group,Bushen Antai Decoction combined with progesterone was adopted.The clinical efficacy,levels of human choronic gonadotropin(HCG)before and after treatment,and disappearing time of symptoms between two groups were compared.Results The total effective rate in the research group was 91.67%,much higher than that in the control group accounting for 72.22%,with a statistical difference(P＜0.05).The HCG level after treatment in the research group was significantly higher than that in the control group,with a statistical difference(P＜0.05).The disappearing time of symptoms in the research group was shorter than that in the control group,which was displayed a statistical difference (P＜0.05).Conclusion The combination of Bushen Antai Decoction and Progesterone Capsules is effective in the treatment of patients with threatened abortion.It can effectively improve the level of HCG and shorten the disappearing time of symptoms. 2017 Vol. 24 (8): 141-143 [Abstract] ( 160 ) HTML (42 KB)  PDF  (0 KB)  ( 37 ) 144 Evaluation of efficacy and safety of combination of Metformin and Insulin in the treatment of type 2 diabetes mellitus LI Qian Objective To evaluate the clinical efficacy and safety of combination of Metformin and Insulin Glargine in the treatment of Type 2 diabetes mellitus.Methods Altogether 60 patients with type 2 diabetes mellitus who were treated in Department of Endocrinology of the Fourth People′s Hospital of Shenyang City from January 2014 to December 2015 and were in line with inclusion criteria were divided into experiment group and control group by random number table method,with 30 cases in each group.Control group was given Premixed Insulin treatment,while experiment group was treated with the combination of Metformin and Insulin Glargine.The fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h BG),glycosylated hemoglobin(HbA1c),body mass index(BMI),insulin dosage and incidence of hypoglycemia events between two groups were observed before and after treatment for 3 months.Results All observation indicators before treatment between two groups showed no significant difference(P＞0.05);FBG,2 h BG,HbA1c,BMI level and insulin dosage after treatment for 3 months in the experiment group was(6.41±0.93)mmol/L,(7.43±1.09)mmol/L,(5.72± 1.53)%,(24.41±2.07)kg/m2and(9.13±3.27)U/d respectively,in contrast with in the control group of(6.53±0.85)mmol/L, (8.75±1.41)mmol/L,(6.53±1.51)%,(26.31±2.11)kg/m2and (15.57±4.21)U/d,with statistically significant difference between two groups(P＜0.05).Conclusion Compared with the application of Premixed Insulin,the combination of application of Metformin and Insulin Glargine in the treatment of type 2 diabetes mellitus is more effective and safe,which is worthy of clinical application. 2017 Vol. 24 (8): 144-146 [Abstract] ( 145 ) HTML (40 KB)  PDF  (0 KB)  ( 40 ) 147 Effect of pharmaceutical intervention on enhancing the rational use of cardiovascular injections made from Chinese herbal medicines in clinic LYU Pei-shan Objective To explore the effect of pharmaceutical intervention on enhancing the rational use of cardiovascular injections made from Chinese herbal medicines in clinic.Methods A total of 300 patients were treated with Chinese herbal medicine injection before pharmaceutical intervention from January to December 2015 in our hospital were selected as control group.Another group of 300 patients with cardiovascular diseases after pharmaceutical intervention from January to December 2016 in our hospital was classified into observation group.The medical cases in the both groups were analyzed.The use of cardiovascular injections made from Chinese herbal medicines,irrational drug usage, and adverse reactions were observed in the two groups.Results The utilization rate of various drugs in the observation group was significantly lower than that in the control group(P＜0.05).The incidence of unreasonable drug usage including medication without indications,over-dose use,drug combination without signs,improper solvent selection and presence of incompatibility were all much lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion Pharmaceutical intervention can not only promote the rational application of cardiovascular medicine injection,but also reduce the adverse reactions,which is worthy of clinical application and promotion. 2017 Vol. 24 (8): 147-149 [Abstract] ( 151 ) HTML (36 KB)  PDF  (0 KB)  ( 36 ) 150 Effectofpillpressing on ear pointon anxiety in the patients receiving maintenance hemodialysis LI Han;ZHONG Jian;CHEN Yi-an;WANG Xiao-lan;CAO Po Objective To observe the effect of pill pressing on ear point on the anxiety of patients receiving maintenance hemodialysis (MHD),and to explore the correlations between the changes of anxiety scores before and after the intervention and urea clearance index(Kt/V),hemoglobin(Hb),serum albumin(Alb),calcium,phosphorus product(Ca×P) and other indicators.Methods A total of 44 patients who were given MHD in the dialysis room in Dongzhimen Hosptial from March to October 2016 were selected.They were randomly divided into two groups.Cross-test design was applied, and the treatment was divided into two stages.Each stage lasted for 6 weeks.The treatment group (22 cases)was given pill pressing on ear point on the basis of conventional hemodialysis treatment,and the control group (n=22)was given conventional hemodialysis treatment.At the end of the first stage,after 4 weeks of elution,the two groups were crossed and the second stage of treatment was started.The Hamilton Anxiety Scale (HAMA)was scored for both groups before the treatment and after the first stage of treatment,at the end of the elution period and after the second stage of treatment.The rate of reduction of score was taken as the evaluation criterion of efficacy,and the indices of Kt/V,Hb,Alb,Ca×P before and after treatment were observed at the same time.Whether they were correlated with the changes of HAMA score was analyzed.Results The score of HAMA in the treatment group were significantly decreased after treatment,and the difference was statistically significant(t= 0.575,P＜0.01).There was no significantdifference in HAMA score in the control group before and after treatment(t= 0.770,P＞0.05);there was no statistically significant correlation between HAMA score and Kt/V before and aftertreatment in both groups(P＞0.05).It was negatively correlated with Hb and Alb,namely when Hb and Alb were increased,HAMA score was decreased.The correlations were allstatistically significant(P＜0.05).It was positively correlated with Ca×P,namely when Ca×P was increased,HAMA score was increased.The correlations were statistically significant(P＜0.05);the total effective rate in the treatment group was 88.6%.Conclusion HAMA score is reduced after the patients with MHD are given pill pressing on ear point,suggesting that pill pressing on ear point can improve the anxiety of MHD patients to a certain extent,and the changes of HAMA score and Hb,Alb and Ca×P are correlated. 2017 Vol. 24 (8): 150-153转163 [Abstract] ( 149 ) HTML (50 KB)  PDF  (0 KB)  ( 32 ) 154 Effect and safety of self-made Chinese medicine lotion combined with Mupirocin in the treatment of pediatric impetigo vulgaris LIN Jie-peng Objective To investigate the efficacy and safety of self-made Chinese medicine lotion combined with mupirocin in the treatment of pediatric impetigo vulgaris.Methods From October 2010 to October 2014,200 children with impetigo vulgaris who were treated in the Department of Dermatology in our hospital were randomly divided into two groups.The control group was treated with Mupirocin alone,and the observation group was treated with self-made Chinese medicine lotion combined with Mupirocin.The efficacy,symptom improvement time and adverse reactions were compared between the two groups.Results The total effective rate was 95%in the observation group,which was significantly higher than that of 82%in the control group,and the difference was statistically significant(P＜0.05);the time of relieving itching,the time of relieving herpes,the time of scabbing,the time of recovery were obviously shorter than those of control group and the rate of recurrence in the observation group was significantly lower than that in the control group,and the differences were statistically significant(P＜0.05);there was no significant adverse reaction between the two groups after drug administration,and some patients showed mild irritation on their skin,there was no significant difference(P＞0.05).Conclusion Self-made Chinese medicine lotion combined with mupirocin in the treatment of pediatric impetigo vulgaris has significant effect,can significantly relieve the symptoms,reduce the auto-implantation induced by scratching,shorten the course of treatment and improve the curative effect,which has a positive clinical significance. 2017 Vol. 24 (8): 154-156 [Abstract] ( 124 ) HTML (39 KB)  PDF  (0 KB)  ( 38 ) 157 Investigation on quality of life and its influencing factors of the primarylevel medical stuff in Lhasa ZHANG Die;CHENG Ru-yuan;CAI Wang;Gong-ga-qu-jie;De-ji Objective To understand the current situation of the quality of life and its influencing factors of primarylevel medical stuf in Lhasa,and to provide theoretical basis for the government to introduce relevant policies to improve the quality of life of medical staff.Methods Form September 2015 to August 2016,primary-level stuffs of 4 country people′s hospitals were chosed to fill chinese edition WHOQOL-BREF scale.Results Compared with the usual domestic model,the score of Tibetan medical stuffs′common sense and health condition was apparently higher than that in the usual domestic model,with significant difference (P＜0.05).The comparison aboutothers fields did not have statistical significance (P＞0.05).The score that common sense,health condition and others fields of Han nationality medical stuffs was obviously lower than that in the domestic model,with significant difference (P＜0.05).Some factors likes nationality, marriage,disease,family friction and appetite influenced the life quality ofprimary-level medicalstuffs(P＜0.05).Conclusion Tibetan medical stuff′s life quality is excellent,but the life quality of Han nationality is stillin urgent need of improvement. The life quality of medical stuffs is influenced by many factors.In addition,the condition of lacking of highly educated talents and asymmetrical distribution ofdoctors and nurses also need improvement. 2017 Vol. 24 (8): 157-159 [Abstract] ( 130 ) HTML (39 KB)  PDF  (0 KB)  ( 41 ) 160 Investigation and analysis of anxiety in Yao nationality rural patients WEI Jie;ZHANG Ai-ping Objective To explore the difference of anxiety of Yao and Han nationality patients in rural areas before operation,and to analyze the related factors of preoperative anxiety in rural patients of Yao nationality.Methods The selfrating anxiety scale and self-made general questionnaire were used to investigate 200 patients undergoing elective surgery in Ruyuan Yao Autonomous County People′s Hospital from March 2015 September 2016 to in rural areas of Yao and Han nationality,100 cases in rural areas of Yao nationality were selected as Yao nationality group,and 100 cases in the the same period in rural areas of Han nationality were selected as Han nationality group.Results The severity of preoperative anxiety of Yao nationality group was worse than that of Han nationality group,and the difference was statistically significant(P＜0.01).The anxiety score of Yao nationality group was(47.58±10.32)scores,higher than that of Han nationality group[(38.16±11.09)scores],and the difference was statistically significant(P＜0.01).The education level,age,caregiver and family economic condition of Yao nationality were the factors of anxiety.The junior middle school and primary school,aged 60 years or more,low social support were the independent risk factors of patients with preoperative anxiety in rural areas of Yao nationality.Conclusion The preoperative anxiety level of Yao nationality patients in rural areas is significantly higher than that of Han nationality patients in rural areas,and there are so many factors,the nursing staff should individualized intervention,to ensure to smooth operation. 2017 Vol. 24 (8): 160-163 [Abstract] ( 132 ) HTML (45 KB)  PDF  (0 KB)  ( 39 ) 164 Observation on immune effect of hepatitis B vaccine in children from 6 months to 5 years old in Yizhou,Guangxi ZHANG Sheng-hong;HUANG Huan-hui;HUANG Dong;HE Wei-ji;OU Jian-lian;WEI Ri-qiang;WEI Ling-xue;WANG Xue-yan Objective To get known the immune effect of hepatitis B vaccine injected in children aged from 6 months to 5 years in Yizhou City in order to provide the basis for hepatitis B vaccine vaccination.Methods From December 1 to 15 in 2015,the serum from 1127 children aged from 6 months to 5 years was collected by multi-stage stratified random sampling,the level of HBsAg and anti-HBs were detected.Results The positive rates of HBsAg and anti-HBs was 0.09%and 84.83%in all participants respectively.The positive rate of anti-HBs in children without enhancement of immunization decreased with age,there was significantdifference in anti-HBs positive rate among allage groups(P＜0.01). There was no significant difference in anti-HBs positive rate among children of different genders (P＞0.05).The anti-HBs positive rate in children living in urban was higher than that in villages (P＜0.01).The positive rate of anti-HBs in children with the history of enhancement of immunization was higher than that without enhancement(P＜0.01).Conclusion Immunization of hepatitis B vaccine in Yizhou has obtained great effect.The immunization effect is related to the factors containing years of immunization,enhanced immunization etc.The key measures to improve the effect of hepatitis B vaccination include implementation of anti-HBs monitoring in an appropriate time,timely enhancement of immunization. 2017 Vol. 24 (8): 164-166 [Abstract] ( 134 ) HTML (39 KB)  PDF  (0 KB)  ( 42 ) 167 Analysis of birth defects surveillance in perinatal infant in Changqing District of Jinan City from 2012 to 2016 LIU Chun-fang Objective To understand the incidence rate and change of birth defects in Changqing District from 2012 to 2016,and to provide reference for the development of intervention measures.Methods The perinatal birth defects in Changqing District from October 2012 to September 2016 were analyzed retrospectively.Results The total number of perinatal fetus was 18 479 cases in 5 years.Among of them,the death of perinatal was 99 cases,died with in 7 days was 9 cases,and the number of defective children was 140 cases(non-including 68 cases of defective childrenwho were less than 28 weeks).The total incidence of birth defects was 75.76/10 000.The rate during 2012 to 2016 was 47.6/10 000-88.9/10 000.It was lower than the level rate of the province but rose year by year.There was significant difference in the incidence of birth defects among different age groups(P＜0.01).The top five birth defects had little change,especially the top three defects which almost had no change in the past three years.While the rate of limb deformity was high in the last 2 years,and neural tube defects did not show a downward trend in 3 years.Conclusion Pregnant women should be careful in doing family guidance in the premarital examination at the same time,who should be guided the regular prenatal care,the publicity and education work shoule be placed in the first place,Folic acid supplement service should be put in place,which can effectively reduce the incidence of birth defects,improve population quality. 2017 Vol. 24 (8): 167-169 [Abstract] ( 121 ) HTML (38 KB)  PDF  (0 KB)  ( 33 ) 170 Investigation on the irrational use of glucocorticoid drugs in outpatients of our hospital in 2016 WANG Shuang;WANG Qin Objective To investigate the use of glucocorticoid drugs in outpatient department of our hospital in 2016,and to ensure the safety and effectiveness of drug use.Methods 1200 outpatient glucocorticoid prescriptions were randomly selected from January to December in 2016,all drawing prescriptions were reviewed,types and statistics of glucocorticoid drugs in clinical diagnosis and other information were counted,and the unreasonable prescription were analyzed.Results 7 kinds of glucocorticoid drugs were useded in the 1200 glucocorticoid drug prescriptions,including 1 kind of oral medicine,3 kinds of injection drugs,3 kinds of inhalation or spray.They were Prednisone Acetate Tablets,Dexamethasone Sodium Phosphate for Injection,Methylprednisolone Sodium Succinate for Injection,Hydroprednisone Injection,Fluticasone Propionate Nasal Spray,Budesonide Suspension,Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation.After prescription comment,1064 reasonable prescriptions were founded in all prescriptions,the rate was 88.67%.136 irrational prescriptions were founded,and super indications medication were used in 114 irrational prescriptions,accounting for 9.50%;route of administration were not suitable in the other 22 irrational prescriptions,accounting for 1.83%.Conclusion The use of glucocorticoid drugs in outpatient department of our hospital in 2016 is basically reasonable,but there are still abuse cases.The special review of glucocorticoid prescription needs to be further strengthened. 2017 Vol. 24 (8): 170-172 [Abstract] ( 135 ) HTML (34 KB)  PDF  (0 KB)  ( 37 ) 173 Investigation on status of nurse functional gastrointesinal disordes in Guangning County primary and second grade hospital LU Hui-fang;FENG Zhong-cheng;TAN Chuan-wen;LI Cheng-wen Objective To investigate on status of nurse functional gastrointesinal disordes (FGIDs)in Guangning county primary and second grade hospital,in order to provide scientific reference for the prevention and control of this disease. Methods 242 case of female nurses who were willing to accept the physical examination in three different levels hospital[People′s Hospital of Guangning County(grade 2A),Hengshan Town Health Center of Guangning County(grade 1A) and Binheng Town Health Center of Guangning County (grade 2B)]from June to December in 2016 were randomly selected to investigate digestive system symptom questionnaire,the prevalence of FGIDs was calculated,and the relevant psychological mood table formats were assessed.Results The total prevalence of nurse FGIDs was 12.81%,the prevalence of the general group was highest(17.05%),the prevalence of the outpatient group was second (15.19%),and the prevalence of the emergency group was lowest(5.33%).The SDKL total score,CNSS total score and MBI total score in the FGIDs group was higher than that in the no FGIDs group,while the EPSQ total score in the FGIDs group was lower than that in the no FGIDs group,with significant difference(P＜0.01).Conclusion The nurse groups are high-risk groups of FGIDs,it has a positive and important role to reduce the occurrence of FGIDs by training the basic psychological quality and targeted interventions. 2017 Vol. 24 (8): 173-175 [Abstract] ( 158 ) HTML (38 KB)  PDF  (0 KB)  ( 38 ) 176 Questionnaire survey analysis of front-line scientific research teachers participating in the undergraduate basic course teaching WANG Wei-wei;CUI Jia-yi;WU Ying-li Objective To understand the degree of satisfaction of undergraduate student to front-line scientific research teachers in the undergraduate basic course teaching,to analyse the advantages and disadvantages of front-line scientific research teachers in the undergraduate course,and in order to provide some improvement suggestions.Methods A questionnaire survey was conducted among 332 undergraduate students in the School of Basic Medical Sciences of Shanghai Jiaotong University School of Medicine from March to December in 2016.Results The results showed that five major problems were raised by the students:the scientific knowledge of the classroom was difficult to master(46%);there were problems in the implementation of the syllabus(26%);the coherence of classroom knowledge was not enough(31%);the bibliography and materials involved in the class were problematic (16%);the examination method should be improved (63%).Conclusion Front-line scientific research teachers have their unique teaching characteristic and advantage in undergraduate education,but its objective nature of the work also led to the occurrence of some problems.Front-line scientific research teachers should be pay more attention to the student′s point of view to understand the difficulties of students,to make appropriate improvements to these problems. 2017 Vol. 24 (8): 176-178转182 [Abstract] ( 132 ) HTML (35 KB)  PDF  (0 KB)  ( 34 ) 179 Impact of extended care on the disease control and life quality in elderly patients with chronic heart failure LIXiu-ying;SHI Zhen-dong;ZHANG Yue Objective To explore the impact of extended care on the disease control and life quality in elderly patients with chronic heartfailure(CHF).Methods 112 elderly patients with CHF from February 2013 to February 2015 in ourhospital were divided into observation group and control group,according to their hospital admission sequence,56 cases in each groups.Patients in observation group were added regular telephone follow-up and family follow-up on the basis of that with in 12 months,and patients in control group were received cycle of internal conventional western medicine and nursing.The readmission rate,mortality rate and changes of life quality of patients in two groups were compared.Results The readmission rate in observation group was 32.1%,obvious lower than that of 62.5%in control group,and the difference was significant(P＜0.01).The mortality rate in observation group was 3.6%,obvious lower than that of 10.7%in control group,and the difference was significant(P＜0.05).The life quality of the two groups were improved compared significantly with pre-treatment(P＜0.05),but the improvement effects in observation group were more obvious(P＜0.05). Conclusion The extended care can effectively control the progression of CHF in elderly patients,reduce the readmission rate,and obvious improve the life quality. 2017 Vol. 24 (8): 179-182 [Abstract] ( 137 ) HTML (44 KB)  PDF  (0 KB)  ( 37 ) 183 Clinical effect of individualized nursing intervention on early acute mastitis WANG Bo-jun;LIU Zheng-rong Objective To explore the clinical efficacy of individualized nursing intervention in patients with early acute mastitis.Methods 108 patients with early acute mastitis from March 2015 to March 2016 were evenly divided into observation group and control group in random,54 cases in each groups.The control group was used regular nursing,while, the observation group was provided individual nursing intervention.The clinical efficacy,breast-feeding after cessation, and incidence of breast abscess were compared in two groups.The nursing satisfaction was also recorded in both groups. Results The total clinical effective rate of observation group was 96.30%,significantly higher than that of control group accounting for 85.19%,with statisticantdifference(P＜0.05).Compared with the controlgroup,the disappearing time ofswelling pain,time of inflammation resolution,and hospital discharge were all greatly shorter in the observation group,with statisticant differences(P＜0.01).The incidence of breast abscess in the observation group was 3.70%,much lower than that in the control group of 14.81%.The rate of breast-feeding after cessation in the observation group was 96.30%,superior to that in the control group accounting for 62.96%,with statisticant difference(P＜0.05).The total nursing satisfaction of observation group was higher than that of control group(P＜0.05).Conclusion The application of individualized nursing intervention in early acute mastitis patientscan effectively improve the therapeutic effect in clinic,shorten course of treatment,and plays a role in promoting breastfeeding,which is worthy of clinical promotion. 2017 Vol. 24 (8): 183-185 [Abstract] ( 126 ) HTML (38 KB)  PDF  (0 KB)  ( 36 ) 186 Application of comprehensive nursing intervention combined with endometrial collector in the follow-up of conservative treatment for patients with endometrial disease SU Yin-zhi Objective To explore the application value of comprehensive nursing intervention combined with endometrial collector in the follow-up of conservative treatment for patients with endometrial diseases.Methods 70 patients with endometrial diseases who received endometrial examination in our hospital from July 2013 and December 2014 were randomly divided into observation group and control group,35 cases in each group.The control group was given routine nursing intervention,while the observation group was given comprehensive nursing intervention.The satisfaction rate of samples and the efficiency of endometrial collector in the detection of endometrial diseases were analyzed.The self-rating anxiety scale(SAS),self-rating depression scale(SDS)and quality of life measurement table(QOL-BREF)were used to assess the psychological status and quality of life.Results The satisfaction rate of samples collected by endometrial collector,and the sensitivity,specificity and accuracy in the detection of endometrial diseases were 95.70%,69.70%, 75.00%and 70.00%,respectively.After intervention,the SAS score and SDS score were significantly lower in observation group[(29.09±0.57),(30.42±1.09)points]than those in control group(P＜0.05).While QOL-BREF score was(85.23±1.34) points,which was significantly higher than that in control group of(69.25±1.86)points(P＜0.05).Conclusion The effect of comprehensive nursing intervention combined with endometrial collector applied in the follow-up of conservative treatment for patients with endometrial disease is good.It can effectively improve the quality of life and emotion and is worth clinical application. 2017 Vol. 24 (8): 186-188 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 189 The effect of mild hypothermia therapeutic apparatus in the treatment of central hyperpyrexia patient after severe craniocerebral injury operation DENG Su-xuan;LU Qing-mei2▲QIN Qian3CHEN Mei-mei1WANG Yu-mei4LU Liu-xue5 Objective To observe the effect of mild hypothermia therapeutic apparatus in the treatment of severe craniocerebral injury patient with central hyperpyrexia after operation.Methods 42 cases of severe craniocerebral injury patients with central hyperpyrexia after operation from January 2015 and December 2016 were selected and divided into observation group and control group,21 cases in each group,according to random number table.Both group were given the routine treatment and nursing,the observation group was cooled down with mild hypothermia therapeutic apparatus when having fever,the control group was performed routine cooling(ice hat,ice pillow,cooling gel sheet,anti-febrile),the body temperature decreases in 0.5,1,2 and 72 hours of two groups after the cooling measurement were recorded and compared,the satisfaction of the patients′family members of were also compared.Results After the cooling treatment,the body temperature was compared of two groups,with statisticant difference(P＜0.01);the temperature change of observation group was bigger than that of control group,the difference was statisticant(P＜0.01);compared to the temperature before cooling measurement,the body temperature was de-creased of observation group after 0.5,1,2 and 72 hours,with statisticantdifference(P＜0.01),the temperature change of the control group after 1,2 and 72 hours was compared with before cooling measurement,with statisticant difference(P＜0.01), but the change after 0.5 hour had no statisticant difference (P＞0.05);the family member′s satisfaction of observation group was 95.24%,higher than that of control group of 47.62%,with statisticant difference (P＜0.01).Conclusion Using mild hypothermia therapeutic apparatus in the treatment of severe craniocerebral injury patients with central hyperpyrexiais convenient,safe and effective;the treatment method can increase job efficiency and the satisfaction of family members of the patient,it is worth to be popularized in primary hospitals. 2017 Vol. 24 (8): 189-191 [Abstract] ( 139 ) HTML (39 KB)  PDF  (0 KB)  ( 41 ) 192 Clinical effect of psychological nursing intervention on depression in patients PAN Gui-chun Objective To explore the value of psychological nursing intervention in treatment depression.Methods 120 depression patients from January 2015 to June 2016 ofour hospital were divided into control group(general treatment and nursing)and observation group (psychological nursing intervention on the basis of control group)according to random number table,60 cases in each group.Intervention effect between two groups were compared.Results After intervention, the HAMD score,SES score,SCCS score and life quality score in two groups were improved than before intervention(P＜0.05),and the improvement in observation group was obvious better than in control group (P＜0.05).Conclusion On the basis of general treatment,using psychological nursing intervention for depression patients can obvious improve the treatment effect and life quality,and is worth to widely popularize in clinical. 2017 Vol. 24 (8): 192-194 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 39 ) 195 Observation on the practical effect of targeted nursing in the nursing of children with pneumonia ZHU Yan Objective To explore the practical effect of targeted nursing in the nursing of children with pneumonia. Methods 100 children with pneumonia treated in our hospital from July 2013 to July 2016 were selected as the research objects.By odd or even number,they were evenly divided into control group and observation group,50 cases in each group.The control group was used regular nursing,while the observation group was adopted targeted nursing.The time of children′s body temperature to normal,hospital stay,family psychological status (SAS and SDS)and nursing satisfaction were compared in two groups.Results The time of children patient′s body temperature to normal and hospital stay in the observation group were both shorter than those in the control group(P＜0.05).The scores of SAS and SDS in patient′s families of observation group were better than those of control group(P＜0.05).The total nursing satisfaction from families in the observation group was 96.00%,significantly better than that in the control group of 80.00%(P＜0.05).Conclusion The application of targeted nursing in children with pneumonia can obtain a remarkable effect.It can also shorten the time of reducing fever and hospital stay,and is worthy of promotion. 2017 Vol. 24 (8): 195-197 [Abstract] ( 123 ) HTML (41 KB)  PDF  (0 KB)  ( 45 )

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