2型糖尿病并不同水平血清TSH亚临床甲状腺功能减退患者的临床特点及高血清TSH水平对患者的影响

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Abstract Objective To analyze the clinical characteristics of type 2 diabetes mellitus and subclinical hypothyroidism with different levels of serum thyrotropin (TSH),and to explore the influence of high serum TSH levels on patients. Methods 75 patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism who were diagnosed and treated in our hospital from May 2012 to May 2016 were selected as the observational group.75 patients with type 2 diabetes mellitus not complicated with subclinical hypothyroidism were selected as the control group at the same period.The clinical characteristics and their influence on complications were compared between the two groups.According to the level of thyrotropin,the patients were divided into the normal group (75 cases),the mildly elevated group(45 cases)and the markedly elevated group (30 cases).The complications of the three groups were compared.Results The level of thyroglobulin antibody (TgAb),thyroid peroxidase (TpoAb)and TSH in the observation group was higher than that in the control group,serum free triiodothyronine(FT3)level in the observation group was lower than that in the control group,with significant difference(P＜0.01).The levels of total cholesterol(CHOL)and low density lipoprotein(LDLC)in the observation group was higher than that in the control group,with significant difference (P＜0.01).There was no significant difference of the level of HDL-C,ApoB and ApoA1 between the two groups(P＞0.05).The incidence rate of complications in the patients with elevated thyrotropin level group was higher than that in the mildly elevated group and the normal group,with significant difference (P＜0.01).Conclusion The abnormal degree of laboratory indices and the incidence rate of complications in patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism are higher than those in healthy people.Therefore,prevention and treatment should be performed in the patients complicated with subclinical hypothyroidism,so as to prevent the occurrence of complications.

Key words： Diabetes mellitus Subclinical hypothyroidism Thyrotropin

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	LIU Cai-juan
	HUA NG Xi-fan
	YANG Jun-feng

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LIU Cai-juan,HUA NG Xi-fan,YANG Jun-feng. Clinical characteristics of different levels of serum TSH subclinical hypothyroidism in patients with type 2 diabetes mellitus and the influence of high serum TSH level on the patients[J]. 中国当代医药, 2017, 24(8): 56-58转68.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I8/56

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