高级别恶性脑胶质瘤术后三维适型放疗联合经颈动脉灌注化疗的效果分析

Abstract
Figure/Table
References (21)
Related Citation (4)

Download: PDF (0 KB) HTML (48 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the clinical efficacy of hree-dimensional conformal radiotherapy (3DcRT)combined with transcatheter arterial infusion chemotherapy in treatment of high-grade malignant glioma (HGG).Methods From March 2009 to February 2013,37 postoperative patients with HGG treated in our hospital confirmed by pathology were divided into two groups according to the random number table method.The control group (n=18;gradeⅢ in 8 cases, gradeⅣin 10 cases)only underwent 3DcRT,the combined treatment group (n=19;gradeⅢin 9 cases,gradeⅣin 10 cases)underwent 3DcRT combined with transcatheter arterial infusion chemotherapy.In the two groups.The combined treatment group was treated with ACNU[2.0 mg／(kg·time)]and VM-26(50 mg/time)for arterial chemoembolization.Single radiation quantity was 2.0 Gy/(time·d),five times per week,the radiotherapy dose(DT)was 50-56 Gy.The times and frequency of chemotherapy were determined according to the patient′s body and tumor situation.The short-term and longterm efficacy and adverse reaction in the two groups were obseved.Results Survival rate of 6,12,24,36 months after treatment in the control group was 77.78%,66.67%,50.00%,38.89%,22.22%respectively,and it was 89.47%,78.95%, 68.42%,52.63%,36.84%respectively in the combined treatment group,and there was a statistical difference between two groups(P＜0.05).The median survivaltime was 11.2 months in the controlgroup and thatwas 18.6 months in the combined treatment group,the differences were significant(χ2=8.76,P＜0.05).Conclusion 3DcRT combined with transcatheter arterial chemoembolization can significantly improve the survival rate and prolong the survival time of patients with HGG than radiotherap alone.

Key words： High-grade malignant glioma;Three-dimensional conformal radiotherapy;Intra-arterial infusion chemotherapy Combination therapy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TANG Tao
	DING Chang-qing
	SUN Zu-jie
	ZHANG Chao

Cite this article:

TANG Tao,DING Chang-qing,SUN Zu-jie, et al. Efficacy analysis of three-dimensional conformal radiotherapy combined with transcatheter arterial infusion chemotherapy in treatment of highgrade malignant glioma[J]. 中国当代医药, 2017, 24(8): 59-62.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I8/59

[1]	Wang P，Li J，Diao Q，et al.ssessment of glioma response to radiotherapy using 3D pulsed-continuous arterial spin labeling and 3D segmented volume[J].Eur J Radiol，2016，85（11）：1987-1992.
[2]	Oike T，SuzukiY，Sugawara K，etal.Radiotherapy plusconcomitant adjuvant temozolomide for glioblastoma：Japanese mono institutional results[J].PLoS One，2013，8（11）：e78943.
[3]	Stupp R，Masn WP，Van den Bent MJ，et al.Radiotherapy plusconmitant and adjuvant temozolomide for glioblastoma[J].N Engl J Med，2005，352（10）：987-996.
[4]	Khan MN，Sharma AM，Pitz M，et al.High-grade glioma management and response assessment-recent advances and current challenges[J].Curr Oncol，2016，23（4）：383-391.
[5]	Dong Y，Fu C，Guan H，et al.Re-irradiation alternatives for recurrent high-grade glioma[J].Oncol Lett，2016，12（4）：2261-2270.
[6]	Christensen E.Choosing the best endpoint[J].J Hepatol，2008， 49（4）：672-673.
[7]	李红梅，冯锐，王秀美，等.伊立替康联合卡培他滨二线治疗晚期结直肠癌[J].中国肿瘤临床，2007，34（16）：942-944.
[8]	王维军，杨华.人脑胶质瘤综合治疗新进展[J].中国医药科学，2014，4（17）：29-31.
[10]	高翔.颅脑肿瘤治疗趋势[J].现代实用医学，2012，24（10）：1084-1087.
[11]	陈婵娟，王家祺，梁永，等.替莫唑胺联合贝伐单抗同步放疗对高级别脑胶质瘤术后患者的疗效分析[J].肿瘤药学，2015，5（2）：126-129.
[12]	徐华，张海萍，李乐.高分级脑胶质瘤术后同步放化疗联合辅助化疗的临床研究[J].现代肿瘤医学，2015，23（7）：914-916.
[14]	郑伟，聂青，康静波，等.高级别脑胶质瘤患者术后同步放化疗的临床疗效研究[J].中华神经医学杂志，2011，10（9）：900-904.
[9]	Tsien C，Galban CJ，Chenevert TL，et al.Parametric response maSp aging biomarker to distinguish progression from pseudoprogression high-grade glioma[J].J Clin Oncol，2010，28（13）：2293-2299.
[13]	Isaka T，Maruno M，Nakata H，et al.Effectiveness of spray application of ACNU in the localofmalignantgliomas：report of two cases[J].Neurol Res，2002，22（2）：181-184.
[15]	傅相平，李安民，张志文，等.经颈动脉灌注ACNU、VM-26联合治疗复发性脑胶质瘤的临床研究[J].中国临床神经外科杂志，2008，13（3）：168-169.
[16]	杨森，董立新，付占昭，等.恶性脑胶质瘤术后三维适形放射治疗的临床疗效及不良反应[J].医学信息，2015，28（48）：312-313.
[17]	Pirtoli L，Rubino G，Marsili S，et al.Three-dimensional conformal radiotherapy，temozolomide chemotherapy，and high dose fractionated stereotactic boost in a protocoldriven，postoperativetreatment schedule for hign-grade gliomas[J].Tumori，2009，95（3）：329-337.
[18]	Qu J，Rizk JD，Fan Y，et al.Establis hment and partial characterization of a human tumor cell line，GBM-HSF，from aglioblastoma multiform[J].Hum Cell，2014，27（3）：129-136.
[19]	汪洋，盛晓芳，高晶，等.高分级神经胶质瘤112例术后放、化疗疗效及其预后分析[J].肿瘤，2009，29（7）：668-672.
[20]	Woods K，Karunamuni R，Tran A，et al.TH-EF-BRB-01：Best in PHYSICS（Therapy）：dosimetric comparison of 4π and clinical IMRT for cortex-sparing high-grade glioma treatment[J].Med Phys，2016，43（6）：3894.
[21]	Snelling B，Shah AH，Buttrick S，et al.The use of MR perfusion imaging in the evaluation of tumor progression in Gliomas[J].J Korean Neurosurg Soc，2017，60（1）：15-20.