轻度认知障碍及阿尔茨海默病的sMRI分析

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Abstract Objective To investigate the characteristics of structural magnetic resonance imaging(sMRI)of mild cognitive impairment(MCI)and Alzheimer disease(AD)in differentbrain regions,and to find out the characteristic indexes so as to provide assistance for early diagnosis.Methods Altogether 543 patients whose number ranged from 4018 to 5210 in the Alzheimer Disease Neuroimaging Initiative(ADNI)database from August 2014 July 2015 were randomly selected as the object of this research and divided into four groups according to the ADNI database diagnostic standards:139 cases in normal cognitive function group(CN),220 cases in early mild cognitive impairment group(EMCI),108 cases in later mild cognitive impairment group(LMCI)and 76 cases in AD group.Mini-Mental State Examination(MMSE)and 272 sMRI data of all the subjects were acquired.And multiple statistics methods were used,including the single-factor variance analysis,multiple comparison,nonparametric test,paired comparison analysis and multiple linear regression analysis,to discover the characteristic index that can make prediction of disease.Results The analysis results showed that among 272 sMRI data,28 indexes of CN group,EMCI group,LMCI group and AD group had statistically significant difference,of which there were 22 indexes in the pairing locations of the left and right brain region.Through analysis of the left and right brain regions by using paired comparison,a more serious atrophy was seen in the left hemisphere.According to the multiple linear regression analysis of 28 sMRI data and MMSE,the lower volume of the left hippocampus played the biggest influence on the MMSE score.Conclusion With the development of MCI into AD,the degree of brain atrophy is gradually increasing,and the left hemisphere is more severe in the progression of disease,among which,the lower volume of the left hippocampal has the greatest influence on the MMSE score.

Key words： Alzhe im er disease Mild cognitive impairment Structural magnetic resonance imaging Mini-mental state rating scale Paired comparative analysis Multiple linear regression analysis

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	QI Xue-dan
	XU Fan-yu
	FAN Zhao

Cite this article:

QI Xue-dan,XU Fan-yu,FAN Zhao. Analysis of sMRI features of mild cognitive impairment and Alzheimer disease[J]. 中国当代医药, 2017, 24(8): 9-13转26.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I8/9

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