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Observation on immune effect of hepatitis B vaccine in children from 6 months to 5 years old in Yizhou,Guangxi |
ZHANG Sheng-hong1 HUANG Huan-hui1▲ HUANG Dong1 HE Wei-ji1 OU Jian-lian1 WEI Ri-qiang1 WEI Ling-xue1 WANG Xue-yan2 |
1.Yizhou Disease Prevention and Control Center,Guangxi Zhuang Autonomous Region,Yizhou 546300,China;
2.Guangxi Center for Disease Control and Prevention,Guangxi Zhuang Autonomous Region,Nanning 530022,China |
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Abstract Objective To get known the immune effect of hepatitis B vaccine injected in children aged from 6 months to 5 years in Yizhou City in order to provide the basis for hepatitis B vaccine vaccination.Methods From December 1 to 15 in 2015,the serum from 1127 children aged from 6 months to 5 years was collected by multi-stage stratified random sampling,the level of HBsAg and anti-HBs were detected.Results The positive rates of HBsAg and anti-HBs was 0.09%and 84.83%in all participants respectively.The positive rate of anti-HBs in children without enhancement of immunization decreased with age,there was significantdifference in anti-HBs positive rate among allage groups(P<0.01). There was no significant difference in anti-HBs positive rate among children of different genders (P>0.05).The anti-HBs positive rate in children living in urban was higher than that in villages (P<0.01).The positive rate of anti-HBs in children with the history of enhancement of immunization was higher than that without enhancement(P<0.01).Conclusion Immunization of hepatitis B vaccine in Yizhou has obtained great effect.The immunization effect is related to the factors containing years of immunization,enhanced immunization etc.The key measures to improve the effect of hepatitis B vaccination include implementation of anti-HBs monitoring in an appropriate time,timely enhancement of immunization.
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