2型糖尿病患者血清同型半胱氨酸与胰岛β细胞功能的关系

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Abstract Objective To explore the relationship between serum homocysteine and islet beta cell function in patients with type 2 diabetes mellitus(T2DM).Methods 118 patients with T2DM in our department of Endocrinology from January 2014 to September 2016 were selected and divided into the T2DM with high serum homocysteine level group and the T2DM with normal serum homocysteine level group according to the level of serum homocysteine,oral glucose tolerance tests(OGTT)and insulin secretion tests were performed in the two groups.The clinical features of gender,age,duration,BMI,FBG,HbA1c,serum homocysteine were compared between the two groups,the steady-state model were used to evaluated the function index of islet beta cell,and which were compared between the two groups.Results There were no significantly differences in sex,age,BMI,duration and the level of FBG,FINS,HbA1c,HOMA-β,AUCI30-120/AUCG30-120between the two groups(P＞0.05).TheΔI30/ΔG30in the T2DM with high serum homocysteine level group was lower than that in the T2DM with normal serum homocysteine level group,with significant difference (P＜0.05).There were positive correlation between homocysteine and age (r=0.229,P=0.006).Conclusion T2DM with high serum homocysteine level may be related to age and the early phase insulin secrction were decreased more severly.

Key words： Type 2 diabetes mellitus Serum homocysteine Islet beta cell function

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	Articles by authors
	ZHA NG Si-qing
	XI Yan-hua
	ZHONG Shu-mei
	GUO Jing-qin

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ZHA NG Si-qing,XI Yan-hua,ZHONG Shu-mei, et al. Relationship between serum homocysteine and islet beta cell function in patients with Type 2 Diabetes Mellitus[J]. 中国当代医药, 2017, 24(8): 53-55.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I8/53

[1]	肖丹丹，诸葛欣，陶珍珍.同型半胱氨酸导致血管内皮细胞损伤机制的研究进展[J].中华临床医师杂志（电子版），2016，10（18）：2789-2793.
[2]	易小艳，胡飞跃，匡金石，等.2型糖尿病肾病患者同型半胱氨酸水平的初步分析[J].中国当代医药，2016，23（1）：77-79.
[3]	李会会，姜涛，文祯，等.羟苯磺酸钙辅助治疗对老年2型糖尿病合并视网膜病变患者血清D-二聚体、同型半胱氨酸及C反应蛋白水平的影响[J].中国老年学杂志，2016，36（18）：4488-4490.
[4]	杨彩娴，黄启亚，钟国权，等.新诊断2型糖尿病早期胰岛素强化治疗后三种治疗方案对胰岛β细胞功能及胰岛素抵抗的影响[J].中华糖尿病杂志，2016，8（10）：613-6179.
[5]	Abdul-Ghani MA，Jenkinson CP，Richardson DK，et al.Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance：results from the Veterans Administration Genetic Epidemiology Study[J].Diabetes，2006，55（5）：1430-1435.
[6]	Haffner SM，Miettinen H，Gaskill SP，et al.Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans[J].Diabetes，1995，44（12）：1386-1391.
[7]	洪世华，吴菊琴，柯瑞琼，等.甘精胰岛素联合格列美脲对比联合吡格列酮治疗初诊2型糖尿病疗效观察[J].中国糖尿病杂志，2014，22（12）：1113-1115.
[8]	冯啸宇.血浆同型半胱氨酸与2型糖尿病大血管病变的相关性研究[D].长春：吉林大学，2016.
[9]	程雯，王华，陈淑雯，等.2型糖尿病患者同型半胱氨酸水平与糖尿病肾病、胰岛素抵抗及糖脂代谢的关系探讨[J].上海预防医学，2016，28（2）：125-128.
[10]	陈德鹏.血浆同型半胱氨酸和胱抑素C与糖尿病周围神经病变的相关性研究[J].中国糖尿病杂志，2014，22（12）：1071-1074.
[11]	刘璐璐.血浆同型半胱氨酸与冠心病及其危险因素的相关性研究[D].长春：吉林大学，2016.
[12]	Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes（UKPDS 34）.UK Prospective Diabetes Study（UKPDS）Group[J].Lancet，1998，352（9131）：854-865.
[13]	刘振平，张艳玲.同型半胱氨酸对胰岛β细胞分泌胰岛素的影响[J].军医进修学院学报，2009，30（4）：540-542.
[14]	张耀，陆菊明，谷伟军，等.同型半胱氨酸对胰岛β细胞胰岛素分泌及凋亡的影响[J].中华医学杂志，2008，88（14）：990-993.
[15]	Scullion SM，Hahn C，Tyka K，et al.Improved antioxidative defence protects insulin producing cells against homocysteine toxicity[J].Chem Biol Interact，2016，256：37-46.