二甲双胍联合胰岛素治疗2型糖尿病的效果及安全性评价

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Abstract Objective To evaluate the clinical efficacy and safety of combination of Metformin and Insulin Glargine in the treatment of Type 2 diabetes mellitus.Methods Altogether 60 patients with type 2 diabetes mellitus who were treated in Department of Endocrinology of the Fourth People′s Hospital of Shenyang City from January 2014 to December 2015 and were in line with inclusion criteria were divided into experiment group and control group by random number table method,with 30 cases in each group.Control group was given Premixed Insulin treatment,while experiment group was treated with the combination of Metformin and Insulin Glargine.The fasting blood glucose(FBG),2-hour postprandial blood glucose(2 h BG),glycosylated hemoglobin(HbA1c),body mass index(BMI),insulin dosage and incidence of hypoglycemia events between two groups were observed before and after treatment for 3 months.Results All observation indicators before treatment between two groups showed no significant difference(P＞0.05);FBG,2 h BG,HbA1c,BMI level and insulin dosage after treatment for 3 months in the experiment group was(6.41±0.93)mmol/L,(7.43±1.09)mmol/L,(5.72± 1.53)%,(24.41±2.07)kg/m2and(9.13±3.27)U/d respectively,in contrast with in the control group of(6.53±0.85)mmol/L, (8.75±1.41)mmol/L,(6.53±1.51)%,(26.31±2.11)kg/m2and (15.57±4.21)U/d,with statistically significant difference between two groups(P＜0.05).Conclusion Compared with the application of Premixed Insulin,the combination of application of Metformin and Insulin Glargine in the treatment of type 2 diabetes mellitus is more effective and safe,which is worthy of clinical application.

Key words： Metformin Insulin Type 2 diabetes mellitus

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LI Qian. Evaluation of efficacy and safety of combination of Metformin and Insulin in the treatment of type 2 diabetes mellitus[J]. 中国当代医药, 2017, 24(8): 144-146.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I8/144

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