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Quick Search     Adv Search 2019 Vol. 26, No. 16 Published: 2019-06-08   4 Influence of Exenatide on homocysteine-induced injury in human umbilical vein endothelial cells DENG Guo-xiong; WEI Jin-ru; CHEN Mei-xiang Objective To explore the influence of Exenatide on homocysteine (Hcy)-induced injury in human umbilical vein endothelial cells (HUVECs).Methods Hcy-induced HUVECs were used to establish an inflammatory injury model,which were divided into the normal group,the model group (200 μmol/L Hcy),the low dose of Exenatide treatment group (200 μmol/L Hcy,ExE-L 5 nmol/L),the medium dose of Exenatide treatment group (200 μmol/L Hcy,ExE-M 10 nmol/L),the high dose of Exenatide treatment group(200 μmol/L Hcy,ExE-H 20 nmol/L).The cell viability in each group was detected,and the content of nitric oxide(NO),the level of interleukin-6(IL-6),the level of intercellular adhesion factor-1(ICAM-1),the level of endothelin-1(ET-1),the expression of inhibitor protein kappa B-alpha(IκBα)and nuclear factor-κB (NF-κB)p65 protein were compared.Results The cell viability,the content of NO and protein expression of IκBα in the model group were significantly lower than that in the control group,the supernatant levels of IL-6,ICAM-1 and ET-1 and protein expression of NF-κB p65 in the model group were significantly higher than those in the control group,with significant difference (P＜0.05).The cell viability,the content of NO and protein expression of IκBα in the each Exenatide group were significantly lower than those in the model group,the supernatant levels of IL-6,ICAM-1,ET-1 and the protein expression of NF-κB p65 in the each Exenatide group were significantly lower than those in the model group,with significant difference(P＜0.05).Conclusion Exenatide can improve Hcy-induced HUVECs,injuried through inhibiting inflammatory response. 2019 Vol. 26 (16): 4-7 [Abstract] ( 80 ) HTML (40 KB)  PDF  (0 KB)  ( 9 ) 8 Relationship between plasma circulating microRNA-328-3p and rheumatic heart disease with atrial fibrillation TANG Chun-shi； LU Xin-lin； TAN Li-hui； CHEN Wen-jiang Objective To investigate whether plasma circulating microRNA-328-3p is related to the occurrence of rheumatic heart disease with atrial fibrillation,and to explore its pathogenesis.Methods A total of 19 patients with rheumatic heart disease and atrial fibrillation from August 2017 to July 2018 were selected as observation group and 21 patients with sinus rhythm of rheumatic heart disease were selected as control group.The expression of plasma circulating microRNA-328-3p was detected by qRT-PCR.The ROC curve of the relative expression of plasma circulating microRNA-328-3p was analyzed.Bioinformatics software such as mirFocus and starBase were used to predict the bioinformatics of microRNA-328-3p.Results The expression level of plasma circulating microRNA-328-3p of the observation group was 0.31±0.05,lower than 0.69±0.03 in the control group,the difference was statistically significant(P<0.01).ROC curve analysis showed that the area under the plasma circulating miR-328-3p curve was 0.9323,95%confidence interval was 0.8598-1.0005 (P<0.01).Bioinformatics predictions showed that the KEGG signaling pathways of microRNA-328-3p were mainly related to cell division,binding protein,ventricular formation,insulin receptor signaling pathway,PI3K pathway,Wnt pathway and so on.The target genes are TLE1,STT3A,USP37,EN2,NRIP1,FOXO4 and so on.Conclusion Plasma circulating microRNA-328-3p may be involved in the occurrence of rheumatic heart disease with atrial fibrillation,and can be used as a biomarker of rheumatic heart disease with atrial fibrillation.It may lead to the occurrence of rheumatic heart disease with atrial fibrillation by regulating PI3K pathway and Wnt pathway. 2019 Vol. 26 (16): 8-11转15 [Abstract] ( 80 ) HTML (39 KB)  PDF  (0 KB)  ( 9 ) 12 Expression and significance of SRSF6 in non-small cell lung cancer MEI Juan-juan； LI Gui-he； HUANG Wei-hua Objective To investigate the expression and significance of serine/arginine-rich splicing factor 6(SRSF6)in non-small cell lung cancer(NSCLC).Methods Seventy-five patients with NSCLC admitted to our hospital from January 2013 to January 2017 were selected as the study subjects and divided into non-small cell lung cancer(NSCLC)tissues and corresponding adjacent tissues according to the different samples,the expression of SRSF6 in non-small cell lung cancer(NSCLC)and its adjacent tissues was detected by immunohistochemical SP method,the relationship between the expression of SRSF6 and gender,age,clinical stage,distant metastasis and differentiation of NSCLC was also analyzed.Results The positive expression of SRSF6 in NSCLC tissues was (1.65±0.48)%,which was significantly higher than(0.57±0.23)%in adjacent tissues,the difference was statistically significant(P<0.05).To investigate the relationship between SRSF6 and clinical parameters of patients with NSCLC,and according to the expression intensity of SRSF6 in lung cancer tissues,SRSF6 was divided into four groups:-,+,++,+++,it was found that SRSF6 expression was not related to age and sex of patients with NSCLC,and there was no significant difference (P>0.05).There were significant differences in clinical stage,distant metastasis and differentiation,the difference was statistically significant(P<0.05).Conclusion SRSF6 is less expressed in adjacent tissues and highly expressed in NSCLC,which provides a theoretical basis for clinical diagnosis and treatment of NSCLC,and helps to provide new ideas for clinical treatment. 2019 Vol. 26 (16): 12-15 [Abstract] ( 79 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 16 Carding and analysis of experimental literature on traditional Chinese medicine hangover SUN Yu； DU Juan； LI An-qi； ZHAO Ying-ying； WANG Meng； ZHANG Ru Through reviewing and searching the literatures of hangover of traditional Chinese medicine(TCM)published from June 2005 to October 2018 on China National Knowledge Internet(CNKI),the current situation and progress of the research on TCM antialcoholism and experiment was understood,and the existing common problems in the paper were analyzed and sorted out to provide the ideas and references for the related researches.In 56 related papers that were searched for the purpose of the study,it was found that the researches on the hangover effect of TCM increased in recent years,such as pharmaceutical dosage forms,production processes,etc.,especially in the fields of pharmacological experimental verification and mechanism of action.At the same time,there were some limitations and inconsistencies in the experimental methods and evaluation indexes of antialcoholic effect,which were not conducive to the screening of antialcoholic drugs and the evaluation of antialcoholic effect. 2019 Vol. 26 (16): 16-19 [Abstract] ( 92 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 20 Research progress of the application of Dexmedetomidine in postoperative analgesia and recovery of laparoscopic colorectal cancer surgery ZENG Shuang； LI Meng-yuan； CHEN Chun Colorectal cancer is currently one of the three most common types of cancer in China,and surgical treatment is still the most effective treatment for colorectal cancer.With the continuous development of endoscopic instruments and surgical techniques,laparoscopic minimally invasive surgery has been widely used in colorectal cancer resection because of its advantages of small trauma and rapid recovery.However,postoperative pain and related complications still affect the postoperative recovery of these patients.As a highly selective α2agonist,Dexmedetomidine has been widely used and beneficial in the perioperative period of colorectal cancer surgery.This article reviews the application of Dexmedetomidine in postoperative analgesia and postoperative recovery of colorectal cancer. 2019 Vol. 26 (16): 20-23 [Abstract] ( 77 ) HTML (43 KB)  PDF  (0 KB)  ( 13 ) 24 Research progress of knee osteoarthritis treatment LI Yan； LI Zhao-wei； REN Rong； LI Ze-qing Knee osteoarthritis (KOA)is also known as knee degenerative disease,is a common and frequent disease.The incidence of the disease increases year by year,which seriously affects the life of the elderly patients and brings a certain burden to the society and families.At present,there are non-surgical treatment and surgical treatment in the treatment of KOA.Non-surgical treatment in clinical can temporarily improve symptoms,improve the quality of life of patients,but the long-term effect is poor,prone to recurrent attacks.But the surgical treatment method is relatively many,mostly is according to the operators′experience,uses the different operation method,lacks the unified step treatment.This article summarizes the methods of treatment in order to provide a reference for clinical treatment of KOA. 2019 Vol. 26 (16): 24-27 [Abstract] ( 84 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 28 Clinical effect of Shexiang Baoxin Pills combined with Losartan in the treatment of hypertension complicated with left ventricular hypertrophy ZHENG Zhi-gang； YU Min； TANG Ping； CHEN Qiao-hong Objective To explore the clinical effect of Shexiang Baoxin Pills combined with Losartan in the treatment of hypertension complicated with left ventricular hypertrophy.Methods A total of 50 patients treated in internal medicince department of our hospital and diagnosed with primary hypertension complicated with left ventricular hypertrophy from June 2013 to March 2018 were selected as the study subjects.All patients were divided into experimental group and control group according to the random number table method,with 25 cases in each group.The control group was treated with Losartan,and the experimental group was treated with Shexiang Baoxin Pills on the basis of the control group.The 24-hour ambulatory blood pressure indexes and echocardiography indexes(left ventricular end diastolic diameter[LVEDD],left ventricular end systolic diameter[LVESD],left ventricular ejection fraction[LVEF])were compared between the two groups before and after treatment,and the incidence of adverse reactions during treatment was compared between the two groups.Results The indexes of 24-hour ambulatory blood pressure after treatment in the experimental group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The LVEDD and LVESD after treatment in the experimental group were significantly lower than those in the control group,and the LVEF was significantly higher than that in the control group,with statistically significant differences (P<0.05).No serious adverse reactions occurred in either group during the course of treatment.Conclusion Shexiang Baoxin Pills combined with Losartan can significantly reduce the blood pressure in the treatment of hypertension complicated with left ventricular hypertrophy,improve the condition of ventricular hypertrophy,and the effect is significant,which is worthy of clinical promotion and application. 2019 Vol. 26 (16): 28-30 [Abstract] ( 117 ) HTML (34 KB)  PDF  (0 KB)  ( 13 ) 31 Effect of chest pain center establishment on the treatment of patients with acute ST-segment elevation myocardial infarction LI De-qing； LIU Zi-yong Objective To investigate the effect of chest pain center establishment on the treatment of patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 269 patients with acute STEMI admitted to our hospital from January 2016 to December 2017 were selected as subjects.The patients were divided according to the time of the patients′visit.The time from January to December 2016(before establishment of chest pain center)was used as the control group(130 cases),and the time from January to December 2017(after establishment of chest pain center)was used as the research group(139 cases).The time from onset to balloon dilatation time(S2B),direct percutaneous coronary intervention(PPCI)from entry to balloon dilation time(D2B),time for thrombolytic therapy from entry to the beginning of thrombolysis(D2N),the incidence rate of heart failure during hospitalization(Killip grade≥2)and the mortality during hospitalization were counted in the two groups,and patients were followed up for 3 months.Results The S2B,D2B and D2N of the research group were shorter than those of the control group,the incidence rate of heart failure and the mortality during hospitalization were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence rate of heart failure,mortality,and other adverse events in the research group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The establishment of the chest pain center can effectively and timely treat patients with acute STEMI,reduce the mortality of STEMI,and thus effectively improve the treatment effect of patients with acute STEMI. 2019 Vol. 26 (16): 31-34 [Abstract] ( 78 ) HTML (35 KB)  PDF  (0 KB)  ( 4 ) 35 Feasibility and safety of Valsartan in the treatment of essential hypertension ZENG Xian-xin Objective To investigate the clinical therapeutic effect of Valsartan in the treatment of essential hypertension,the improvement of ambulatory blood pressure and the safety of treatment.Methods Forty-eight patients with primary hypertension admitted to our hospital from October 2015 to October 2017 were selected and divided into observation group and control group according to random number table method,24 cases in each group.The patients in the observation group were given Ammonia Chloride 5 mg/d plus Valsartan 80 mg/d,the control group received Amlodipine 5 mg/d,the two groups were treated for 5 months,the treatment of total effective rate,ambulatory blood pressure monitoring and incidence of adverse reactions were compared detween the two groups.Results The total effective rate of treatment in the observation group (95.83%)was significantly higher than that in the control group (70.83%),and the difference was statistically significant(P<0.05).The 24-hour systolic blood pressure (SBP),24-hour systolic blood pressure variability (SBPV),24-hour diastolic blood pressure (DBP),and 24-hour diastolic blood pressure variability(DBPV)were significantly lower in the observation group than in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion The clinical effect of valsartan in the treatment of essential hypertension is clear,it can positively improve the blood pressure status of patients,and it is safe and worthy of clinical application. 2019 Vol. 26 (16): 35-37 [Abstract] ( 87 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 38 Application effect of Leech Powder in the treatment of patients with cerebral infarction LI Xi-nian； NIU Peng； ZENG Ji-chao Objective To observe the effect of Leech Powder in the treatment of patients with cerebral infarction.Methods A total of 50 cases of patients with cerebral infarction treated in our hospital from June 2017 to November 2018 were selected as the subjects,and randomly divided into two groups,with 25 cases in each group.The control group were treated with routine prevention,the study group were treated with Leech Powder on the basis of routine prevention.The blood hematovascular pseudohemophilia factor(vWF),platelet alpha-granule membrane protein 140(GMP-140)levels,neurological deficit scores,life state scores and clinical efficacy of the two groups were statistically analyzed.Results The blood vWF level,neurological deficit score and living ability score of the study group were significantly lower than those of the control group,the differences were statistically significant(P<0.05),and the total treatment effective rate(84.0%[21/25])was significantly higher than that of the control group(72.0%[18/25]),the difference was statistically significant(P<0.05).The difference of GMP-140 after treatment between the two groups was not significant(P>0.05).Conclusion Leech Powder has significant effect in the treatment of neurological function of patients with cerebral infarction. 2019 Vol. 26 (16): 38-40 [Abstract] ( 118 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 41 Effect comparison of aneurysm clipping and endovascular embolization of coil tumors operation in the treatment of high-grade aneurysmal subarachnoid hemorrhage YANG Na； LI Ji-hua； LI Ren-zi； YUAN Bin； MA Jun-chi； GAO Jian-chao； CUI Yong-peng； LIU Yun Objective To compare the effect of aneurysm clipping and endovascular embolization of coil tumors operation in the treatment of high-grade aneurysmal subarachnoid hemorrhage.Methods A total of 110 patients with highgrade aneurysmal subarachnoid hemorrhage treated in our hospital from September 2016 to February 2018 were selected and they were divided into the control group and the observation group according to the random digital table method,there were 55 cases in each group.The two groups were given with conventional subarachnoid hemorrhage treatment.On this basis,patients in the control group were treated by the aneurysm clipping operation,while patients in the observation group were treated by the endovascular embolization of coil tumors operation.After 3 months of treatment,the incidence of complications were recorded and compared between the two groups.The Glasgow prognosis scale(GOS)was used to evaluate the efficacy and prognosis of the two groups.Results The good prognosis rate of the observation group was 54.55%,which was higher than that of the control group(38.18%),and the difference was statistically significant(P<0.05).There was no significant difference in GOS score between the two groups before treatment(P>0.05),after treatment,the GOS scores of both groups decreased,and the scores of observation group were lower than those of control group,and the differences were statistically significant(P<0.05).The main complications of the two groups were rebleeding,hydrocephalus and cerebral vasospasm.The total incidence of complications in the observation group was 16.36%,which was significantly lower than that in the control group(30.93%),and the difference was statistically significant(P<0.05).Conclusion Aneurysm clipping and endovascular embolization of coil tumors operation in the treatment of high-grade aneurysmal subarachnoid hemorrhage can achieve certain therapeutic effect,but the total incidence of complications after endovascular embolization of coil tumors operation is lower,with higher safety and better curative effect. 2019 Vol. 26 (16): 41-43 [Abstract] ( 98 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 44 Significance of MIF gene polymorphism in patients with ischemic stroke MENG Li-li； LU Jun-hua； XU Ying； ZHANG Li Objective To explore the significance of MIF gene polymorphism in patients with ischemic stroke(CIS).Methods All of 146 patients with CIS who treated in Mudanjiang Medical School Affiliated Hongqi hospital and 143 healthy persons who examined in the physical examination center were selected as object of study from December 2017 to November 2018.They were divided into stroke group and healthy group.The genotype and allele frequency of MIF-173 G/C polymorphic loci were compared between the two groups.Results In terms of genotype analysis results of MIF-173 G/C polymorphic loci,the GG gene frequency of stroke group was lower than that of healthy group,and the CC gene frequency was higher than that of healthy group.In terms of the frequency comparison results of mif-173 g/C allele,the frequency of MIF-173 G/C allele G in the stroke group was lower than that in the healthy group,and the frequency of allele C was higher than that in the healthy group.The differences were statistically significant(P<0.05).Conclusion People with MIF-173CC have a higher risk of stroke,and allele C increases the risk of stroke. 2019 Vol. 26 (16): 44-46 [Abstract] ( 86 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 47 Effect of Shugan Jieyu Capsules combined with Aripiprazole in the treatment of schizophrenia and its influence on the levels of oxidative stress GAO Yun； LU Wei-yu； CUI Wen-yan； ZHONG Yu-long； GUO Yue-ping； KUANG Ye Objective To observe the effect of Shugan Jieyu Capsules combined with Aripiprazole in the treatment of schizophrenia and its influence on the levels of oxidative stress.Methods A total of 80 patients diagnosed with schizophrenia and treated in our hospital from January to December 2018 were selected as research objects,and they were divided into the control group and the observation group according to the random principle,40 cases in each group.The control group was treated with Aripiprazole orally,while the patients in the observation group were treated with Shugan Jieyu Capsules combined with Aripiprazole orally.The positive and negative symptom scale (PANSS)scores and the levels of oxidative stress indicators(total superoxide dismutase[T-SOD],glutathione peroxidase[GSH-Px],catalase[CAT])before and after treatment were observed between the two groups.The total effective rate of treatment was compared between the two groups of patients.Results There were no significant differences in the PANSS scores between the two groups before treatment(P>0.05).The PANSS scores of the two groups after 8 weeks of treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The score of negative symptoms in the observation group was significantly lower than that in the control group after 8 weeks of treatment,and the difference was statistically significant(P<0.05).There was no significant difference in the total effective rate of treatment between the two groups (P>0.05).There were no significant differences in serum levels of T-SOD,GSH-Px and CAT between the two groups before treatment(P>0.05).After treatment,the serum levels of T-SOD and GSH-Px in the two groups were higher than those before treatment,and the CAT level was significantly lower than that before treatment,with statistically significant differences(P<0.05).The serum levels of T-SOD and GSH-Px in the observation group after treatment were higher than those in the control group,and the CAT level was lower than that in the control group,with statistically significant differences (P<0.05).Conclusion Shugan Jieyu Capsules combined with Aripiprazole can effectively improve the clinical symptoms of schizophrenia patients and help to enhance the oxidative stress ability of patients. 2019 Vol. 26 (16): 47-50转54 [Abstract] ( 122 ) HTML (44 KB)  PDF  (0 KB)  ( 16 ) 51 Clinical effect of Yangxue Qingnao Granules in the adjunctive treatment of emotional disorder insomnia LIAO Shang； YANG Jing； LIU Li-fang Objective To investigate the effect of Yangxue Qingnao Granules combined with Paroxetine in the treatment of patients with emotional disorder insomnia and its influence on thyroid hormone levels.Methods Ninety-six patients with emotional disorders insomnia who were treated in our hospital from January 2017 to May 2018 were selected as the study subjects.They were divided into observation group and control group according to the order of treatment,48 cases in each group.The patients in the control group were treated with Paroxetine Hydrochloride Tablets orally,and the patients in the observation group were supplemented with Yangxue Qingnao Granules on the basis of the control group with the way of dissolution,8 weeks was a course of treatment.The Pittsburgh sleep quality index(PSQI)and Hamilton anxiety scale(HAMA)were used to evaluate the sleep and anxiety status of the two groups before and after treatment.The levels of thyroid hormones(triiodothyronine[T3],thyroxine[T4],thyrotropin releasing hormone[TRH],and thyroid stimulating hormone[TSH])were measured before and after treatment in both groups.The incidence of adverse reactions during the treatment was recorded between the two groups.Results There were no significant differences in scores of PSQI and HAMA between the two groups before treatment(P>0.05).The scores of PSQI and HAMA in the two groups after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).The scores of PSQI and HAMA in the observation group after treatment were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in levels of T3,T4,TRH and TSH between the two groups before treatment(P>0.05).The levels of T3,T4,TRH and TSH in the two groups after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of T3,T4,TRH and TSH in the observation group after treatment were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence rate of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Yangxue Qingnao Granules can significantly improve the sleep and anxiety symptoms of patients with emotional disorders insomnia,and regulate thyroid hormone levels,which is safe and reliable. 2019 Vol. 26 (16): 51-54 [Abstract] ( 94 ) HTML (38 KB)  PDF  (0 KB)  ( 9 ) 55 Clinical effect of hyperbaric oxygen combined with motor imagination and in-cabin exercise in the treatment of cerebral infarction hemiplegia LEI Jing-kuan； LIU Jin； GUO Tian-chang； LIANG Li-shao Objective To explore the clinical effect of hyperbaric oxygen combined with motor imagination and in-cabin exercise in the treatment of cerebral infarction hemiplegia.Methods A total of 100 patients with cerebral infarction hemiplegia motor dysfunction diagnosed in our hospital from June 2016 to August 2018 were selected as subjects and randomly divided into treatment group(n=50)and control group(n=50).After the comprehensive treatment of patients in the two groups in the internal medicine department,all patients were treated with hyperbaric oxygen in a single pure oxygen chamber,and the treatment group was given the motor imagination therapy in the cabin.The motor function(upper limb Brunnstrom functional grading,lower limb Brunnstrom functional grading)and self-care ability (daily activity ability improved Barthel index score)were compared of the two groups before and after treatment.Results There were no significant differences in the Brunnstrom functional grading of the upper limb,the Brunnstrom functional grading of the lower limb,and the daily activity ability improved Barthel index score before treatment(P>0.05).The Brunnstrom functional grading of the upper limbs and the Brunnstrom functional grading of the lower limbs after treatment in the two groups were better than those before treatment,the daily activity ability improved Barthel index scores were higher than those before treatment,and the differences were statistically significant(P<0.05).The Brunnstrom functional grading of the upper limbs and the Brunnstrom functional grading of the lower limbs after treatment in the treatment group were better than those in the control group,the daily activity ability improved Barthel index score was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion The oxygen combined with motor imagination and in-cabin exercise therapy can improve motor function and self-care ability of patients with cerebral infarction hemiplegia. 2019 Vol. 26 (16): 55-58 [Abstract] ( 86 ) HTML (37 KB)  PDF  (0 KB)  ( 15 ) 59 Clinical effect of Fluoxetine combined with antipsychotics in the treatment of schizophrenia with obsessive-compulsive symptoms LIANG Qi-sheng； DU Ying Objective To investigate the clinical effect of Fluoxetine combined with antipsychotics in the treatment of schizophrenia with obsessive-compulsive symptoms.Methods A total of 83 schizophrenia patients with obsessive-compulsive symptoms who were treated in our hospital from August 2016 to March 2018 were selected as subjects.All patients met the diagnostic criteria of schizophrenia in the International Classification of Diseases(10th edition)(ICD-10),and they were divided into the control group(n=41)and the study group(n=42)according to the random number table method.Patients in the control group were treated with antipsychotics,and patients in the study group were treated with Fluoxetine on the basis of the control group.The treatment effect,the scores of Yale-Brown obsessive compulsive scale(Y-BOCS)and positive and negative symptom scale (PANSS)were observed and analyzed between the two groups of patients before treatment and after 8 weeks of treatment.The treatment emergent symptom scale (TESS)was used to record the incidence of adverse reactions during treatment in both groups.Results The total effective rate of treatment in the study group was 90.48%,which was significantly higher than that in the control group (70.73%),and the difference was statistically significant(P<0.05).There were no significant differences in the scores of Y-BOCS and PANSS between the two groups before treatment(P>0.05).The scores of Y-BOCS and PANSS in the two groups after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.01).The scores of Y-BOCS and PANSS in the study group after treatment were significantly lower than those in the control group,and the differences were statistically significant(P<0.01).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Fluoxetine combined with antipsychotics can significantly improve the mental and obsessive-compulsive symptoms in patients with obsessive-compulsive schizophrenia,and it does not increase the adverse reaction,which has the clinical application value. 2019 Vol. 26 (16): 59-61转64 [Abstract] ( 95 ) HTML (35 KB)  PDF  (0 KB)  ( 10 ) 62 Effect comparison of Aspirin and Nimodipine in the treatment of migraine SHENG Fei； LI Ting-yi； LI Wen-hui Objective To observe and analyze the effects of Aspirin and Nimodipine in the treatment of migraine.Methods A total of 100 migraine patients who treated in our hospital from August 2016 to August 2018 were selected as the study subjects.According to the different treatment regimens,the patients were divided into study group and reference group,50 cases in each group.Among them,patients in the reference group were treated with Nimodipine,while in the study group,Aspirin was adopted.The therapeutic effects of the two groups were compared,including observation of overall treatment effectiveness rate,incidence of complications,and recurrence rate.Results The total effectiveness rate in the study group was 96.00%,higher than that in the reference group accounting for 80.00%with significant difference (P<0.05).The total incidence of complications in the study group was 4.00%,greatly lower than that in the study group accounting for 18.00%with statistical difference (P<0.05).The recurrence rate in the study group was 2.00%,significantly lower compared with that in the reference group accounting for 18.00%with significant difference(P<0.05).Conclusion In the treatment of migraine,both Nimodipine and Aspirin can obtain certain effects,but the effect is more remarkable used by Aspirin than Nimodipine. 2019 Vol. 26 (16): 62-64 [Abstract] ( 83 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 65 Analysis of influencing factors of delayed intracerebral hematoma after craniocerebral injury CAO Huang-rong； FAN Yue-feng Objective To analyze the influencing factors of delayed intracerebral hematoma after craniocerebral injury.Methods A total of 144 patients with craniocerebral injury who were treated in our hospital from January 4,2015 to December 18,2018 were selected as research objects,including 72 patients with delayed intracerebral hematoma after craniocerebral injury and 72 patients with simple craniocerebral injury.According to different disease types,72 patients with simple craniocerebral injury were used as control group,and 72 patients with delayed intracerebral hematoma after craniocerebral injury were used as observation group.Both groups received plasma D-dimer test(immunotactic turbidimetry),the clinical data of patients with craniocerebral injury were compared,and the influencing factors of delayed intracerebral hematoma after craniocerebral injury were analyzed by Logistic regression.Results The proportions of midline shift>0.5 cm,ring pool blur or disappearance and subarachnoid hemorrhage(SAH)in the observation group were higher than those in the control group,the Glasgow outcome scale(GOS)score and the Glasgow coma scale(GCS)score were lower than those in the control group,and the D-dimer level was higher than that in the control group,with statistically significant differences(P<0.05).Logistic regression analysis showed that SAH,ring pool blur or disappearance,midline shift>0.5 cm,D-dimer level and GCS score were the influencing factors of delayed intracerebral hematoma after craniocerebral injury (P<0.05).Conclusion The influencing factors of delayed intracerebral hematoma after craniocerebral injury are closely related to SAH,ring pool blur or disappearance,midline shift>0.5 cm,D-dimer level and GCS score. 2019 Vol. 26 (16): 65-67转70 [Abstract] ( 95 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 68 Effect comparison of different doses of Butylphthalide in the treatment of cerebral infarction LYU Jiang-hua Objective To explore the clinical effect of different doses of Butylphthalide in the treatment of cerebral infarction.Methods A total of 80 patients with cerebral infarction admitted to our hospital from December 2015 to December 2017 were selected as the research objects.According to the random sampling method,they were divided into control group and observation group,with 40 cases in each group.All patients were treated with Butylphthalide.The dose of control group was 100 mg/time,and that of observation group was 200 mg/time.All patients were treated for one month.The short-term curative effect of two groups of cerebral infarction patients was compared.Results The neurological deficit scores of the patients with cerebral infarction in the observation group were lower than those in the control group at 2 weeks and 1 month after treatment,and the differences were statistically significant(P<0.05).The scores of daily living ability index in the observation group were higher than those in the control group at 2 weeks and 1 month after treatment,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group for one month,and the difference was statistically significant(P<0.05).Conclusion High dose of Butylphthalide in the treatment of cerebral infarction in the short term effect is remarkable,can significantly improve the neurological deficits in patients with cerebral infarction,and improve the daily living ability of patients,improve the quality of life of patients,the application effect is satisfactory. 2019 Vol. 26 (16): 68-70 [Abstract] ( 97 ) HTML (30 KB)  PDF  (0 KB)  ( 15 ) 71 Effect of shock wave combined with transcutaneous electrical nerve stimulation in treatment of gastrocnemius spasm after stroke YE Hui-min； DING De-quan； LI Yue-tao Objective To explore the application value of shock wave combined with transcutaneous electrical nerve stimulation （TENS）in treatment of gastrocnemius spasm after stroke (CVA).Methods All of 30 cases of patients with gastrocnemius spasm after CVA who received in our hospital from February to July 2018 were selected,and were numbered by the odd and even.15 cases of odd numbered patients were treated with shock wave combined with TENS as the observation group,while 15 cases of even number of patients were treated with TENS as the control group.Then,the treatment effect and changes of the length of the gastrocnemius muscle bundles,the exercise energy (FMA)score and activity of daily living(ADL)score before and after treatment of two groups of patients were compared.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than that in the control group of 73.33% (P<0.05).There was no significant difference in ankle 0°position and ankle plantar flexion 30°position extremely acute fasciculus length before treatment between the two groups(P＞0.05).After treatment,the ankle 0°position and ankle metatarsal flexion 30°position extremely acute fasciculus length in the observation group were significantly higher than those in the control group (P<0.05).Before treatment,there was no significant difference in FMA and ADL scores between the observation group and the control group (P＞0.05).After treatment,the scores of FMA and ADL in the observation group were higher than those before treatment and in the control group(P<0.05).Conclusion The treatment effects of shock wave combined with TENS in treatment of gastrocnemius spasm after CAV are significant,which can effectively promote the recovery of motor function of patients,thus it is worth promoting and using. 2019 Vol. 26 (16): 71-73 [Abstract] ( 77 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 74 Clinical effect of low dose Valproic Acid combined with Lamotriazine in the treatment of epilepsy XIE Bing-xiu； WANG Zao-ming； ZHANG Kang-jing Objective To observe the clinical effect of low-dose Valproic Acid combined with Lamotrigine in the treatment of epilepsy.Methods A total of 110 patients with epilepsy admitted to our hospital from November 2016 to December 2017 were selected as the subjects of study.According to random lottery,the patients were divided into control group(55 cases)and observation group(55 cases).The control group was treated with Lamotrigine,while the observation group was treated with low-dose Valproic Acid combined with Lamotrigine.The clinical efficacy,duration,frequency and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group(96.36%)was higher than that of the control group(78.18%),and the difference was statistically significant(P<0.05).The duration of seizures in the observation group was (2.12±0.71)minutes,which was shorter than that in the control group(3.10±0.99)minutes,and the difference was statistically significant(P<0.05).The number of episodes in the observation group was(0.45±0.21)times,less than that in the control group(1.25±0.46)times,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Clinical treatment of patients with epilepsy can take a small dose of Valproic Acid combined with Lamotrigine therapy,the treatment effect is significant,can shorten the duration and frequency of attacks.Reducing the incidence of adverse reactions,and can be widely used in clinical practice 2019 Vol. 26 (16): 74-76 [Abstract] ( 80 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 77 Effect of Agomelatine combined with Compound Diazepam treating depression-anxiety comorbidity CHEN Wen-ying； DU Zhi-hua； LI Li Objective To investigate the clinical effect of Agomelatine combined with Compound Diazepam treating depression-anxiety comorbidity.Methods A total of 90 patients with depression and anxiety comorbidity treated in our hospital from February 2016 to February 2017 were selected and they were randomly divided into group A (n=30)and group B(n=30),group C(n=30).Group A was treated with Agomelatine combined with Compound Diazepam,group B was treated with Compound Diazepam Tablets,and group C was treated with Agomelatine.Clinical efficacy and the incidence of side reaction were compared among the three groups.Results Before treatment,the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)scores of the three groups were not significantly different(P>0.05).After treatment,the HAMD and HAMA scores of group A were significantly lower than those of group B and C(P＜0.05).There were no significant differences in the TESS scores among the three groups(P>0.05).Conclusion The combination of Agomelatine and Compound Diazepam in the treatment of depression and anxiety comorbidity can effectively improve the anxiety and depression of patients,and has high safety and can help patients to return to normal life as soon as possible. 2019 Vol. 26 (16): 77-79 [Abstract] ( 129 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 80 Effect of Amisulpride in the treatment of female patients with schizophrenia ZHANG Yang-guang； CAO Huo-jun； JIANG Chuan-xun； LI Dan Objective To investigate the effect of Amisulpride in the treatment of female patients with schizophrenia.Methods From October 2017 to April 2018,86 female schizophrenia patients admitted to our hospital were enrolled in the study.According to a random number table,they were assigned to the study group(n=43)and the control group(n=43).In the study group,Amisulpride was used,while in the control group,Risperidone was adopted.After 24-week observation,the total scores of the personal and social performance scale (PSP)before and after treatment,the incidence of adverse reactions,and serum prolactin levels before and after treatment were compared.Results The total scores of PSP after treatment were significantly higher than those before treatment in the two groups(P<0.05).The total score of PSP in the study group was higher than that in the control group after treatment(P<0.05).Serum prolactin levels in the two groups at 6 and 24 weeks after treatment were higher than those before treatment,and after 24-week treatment,the blood prolactin levels were higher than those at 6 weeks (P<0.05).There were no significant differences in prolactin levels between the two groups before treatment and after treatment at 6 and 24 weeks(P>0.05).There was no significant difference in the incidence of extrapyramidal reaction,constipation,headache,amenorrhea and lactation between the two groups (P>0.05).Conclusion Amisulpride applied to female schizophrenia can markedly improve the social function.After treatment,serum prolactin levels are elevated,but without the increase of the incidence of amenorrhea and lactation. 2019 Vol. 26 (16): 80-82 [Abstract] ( 100 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 83 Influencing factors analysis of time window of intravenous thrombolysis for acute cerebral infarction HE Miao-hong； XU Ji-fen； YAO Bing-ming Objective To analyze the influencing factors of the time window of intravenous thrombolytic therapy for acute cerebral infarction.Methods The clinical data of 104 patients with acute cerebral infarction treated in our hospital from June 2016 to June 2018 were retrospectively analyzed.The patients were divided into group A (time interval≤3 hours,34 cases)and group B (time interval>3 hours,70 cases).The data of living style,place of onset and route of delivery to emergency department of the two groups were collected and compared,and the influence of intravenous thrombolytic therapy on acute cerebral infarction was analyzed.Single factor of time window and risk factors of occurrence were analyzed by Logistic.Results The proportion of children in group A living with their spouses,understanding the symptoms of cerebral infarction,understanding the thrombolytic therapy of cerebral infarction,understanding the time window of thrombolytic therapy and emergency 120 visits rate were higher than those in group B,and the proportion of children living alone was lower(P<0.05).Logistic analysis showed that solitude was a risk factor affecting the time window of intravenous thrombolytic therapy in acute cerebral infarction(OR>1,P<0.05).The protective factors affecting intravenous thrombolysis time window of acute cerebral infarction were children′s residence,understanding of cerebral infarction symptoms,thrombolysis therapy,thrombolysis time window and emergency 120 visits （OR<1,P<0.05）.Conclusion Living alone is a risk factor affecting the time window of intravenous thrombolytic therapy for acute cerebral infarction.Intervention measures should be taken in time to improve the therapeutic effect of intravenous thrombolysis for highrisk patients. 2019 Vol. 26 (16): 83-85 [Abstract] ( 76 ) HTML (29 KB)  PDF  (0 KB)  ( 10 ) 86 Clinical effect comparison of microchannel percutaneous nephroscope and retroperitoneoscope in the treatment of incarcerated upper ureteral calculi YAN Quan-hua Objective To investigate the clinical effect of microchannel percutaneous nephroscopy and retroperitoneal laparoscopy in the treatment of incarcerated upper ureteral calculi.Methods A total of 80 cases of incarcerated upper ureteral calculi admitted to our hospital from January 2017 to March 2018 were selected as research objects.The patients were divided into two groups,with 40 cases in each group.The control group was treated by retroperitoneal laparoscopic lithotomy,and the study group was treated by microchannel percutaneous nephroscopy.Operative time,intraoperative bleeding,stone removal rate,length of hospital stay,visual analogue score(VAS)for postoperative pain and complications were compared between the two groups.Results The operation time and hospitalization time of patients in the study group were shorter than those in the control group,and the VAS score of 24 h after surgery was lower than that in the control group,the differences were statistically significant(P<0.05),while there was no significant difference in intraoperative blood loss between the two groups(P>0.05).The stone removal rate in the study group(100.00%)was higher than that in the control group(90.00%),and the difference was statistically significant(P<0.05).The total incidence of complications in the study group(5.00%)was compared with that in the control group(7.50%),and the difference was not statistically significant(P>0.05).Conclusion Microchannel percutaneous nephrolithotomy for the treatment of incarcerated upper ureteral calculi has definite clinical effect,and has the advantages of simple operation,quick recovery and so on.It also has advantages in stone removal rate and is worth learning. 2019 Vol. 26 (16): 86-88 [Abstract] ( 66 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 89 Application of spiral CT in the treatment of complicated stones with multi-mirror lithotripsy YU Zhao-cun； HUANG Hua-sheng； YANG Chang-jun； FANG Zhong-jin； CHEN Zao-qing Objective To explore the value of spiral CT in the treatment of complex calculi with multi-mirror combined with lithotripsy.Methods From January 2016 to October 2018,60 patients with complicated calculi were initially diagnosed in our hospital by color Doppler ultrasound and abdominal plain film.They were divided into experimental group and control group by simple randomization method,with 30 cases in each group.In the experimental group,spiral CT scan and three-dimensional reconstruction were performed,and the established model was used to locate the stones and guide the selection of treatment options.In the control group,ordinary CT scan was used to guide the selection of surgical program.The operation time,postoperative hospitalization time,diagnostic effect,stone removal rate and complication rate were compared between the two groups.The value of spiral CT in the treatment of complex calculi with multi-mirror combined with lithotripsy was discussed.Results The diagnostic coincidence rate of stones in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).The primary stone clearance rate,secondary stone clearance rate and total stone clearance rate in the experimental group were all higher than those in the control group,with statistically significant difference(P<0.05).The operation time and hospitalization time of the experimental group were shorter than that of the control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Spiral CT can accurately diagnose stones,clear the three-dimensional structure of stones and kidneys,and guide multi-mirror combined with lithotripsy in the treatment of complex calculus.It is worthy of clinical application. 2019 Vol. 26 (16): 89-91转107 [Abstract] ( 75 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 92 Effect of ureteroscopic holmium laser lithotripsy in the treatment of incarcerated ureteral calculi complicated with inflammatory polyps MAI Zuo-lian； CAI Hua-zai； YUAN Ping-qing； MA Zhi-yong； WANG Zuo-min； GU Jian-feng； LI Yong-hao； YI Sheng Objective To investigate the clinical efficacy of ureteroscopic holmium laser lithotripsy in the treatment of incarcerated ureteral calculi complicated with inflammatory polyps.Methods A total of 72 patients with invasive ureteral calculi complicated with inflammatory polyps admitted to the Fifth People′s Hospital of Foshan City from March 2016 to March 2018 were selected as subjects.The 72 patients were divided into control group (36 cases)and observation group (36 cases)by random number table method.Patients in the control group underwent routine open surgery,and patients in the observation group were treated with ureteroscopic holmium laser lithotripsy.The clinical indicators,clinical efficacy and postoperative adverse reactions of the two groups were compared.Results The duration of surgery,the time of postoperative spontaneous recovery,and the length of hospital stay were shorter in the observation group than those in the control group,the intraoperative blood loss was less than that in the control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative adverse reactions was lower than that of the control group,and the difference was statistically significant(P<0.05).The total treatment efficiency of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The use of ureteroscopic holmium laser lithotripsy is effective in the treatment of patients with invasive ureteral calculi complicated with inflammatory polyps.This procedure has high clinical value and safety. 2019 Vol. 26 (16): 92-94 [Abstract] ( 75 ) HTML (34 KB)  PDF  (0 KB)  ( 12 ) 95 Correlation study of calcification factors in radial artery in uremia patients MO Yi-hao； SONG Dai-kun； KANG Wen-hui； WANG Li； HU Ming-liang Objective To investigate the correlation of calcification factors of radial artery in uremia patients.Methods From January 2015 to December 2016,60 cases of uremic patients treated in our hospital were selected as the research objects.The von Kossa staining for radial artery blood vessel,and X-ray film for both hands and pelvis was photographed.The vascular calcification score was calculated,blood pressure indexes were measured,blood biochemical indexes such as phosphorus and calcium were detected,and the level of whole parathyroid hormone was detected,and the correlation of vascular calcification was analyzed.Results In this study,a total of 29 patients developed radial artery calcification,accounted for 48.33%.The serum phosphorus,calcium phosphate product,alkaline phosphatase,parathyroid hormone,vascular calcification rate and vascular calcification score of the patients with radial artery calcification were all higher than those patients without radial artery calcification,and the differences were statistically significant(P<0.05).There was no significant difference in age,gender,serum total calcium and serum creatinine between patients with and without radial artery calcification (P>0.05).Vascular calcification was taken as the dependent variable,and the results of multiple linear regression suggested that there were positive correlation between high level of serum phosphorus,total parathyroid hormone vascular calcification rate,alkaline phosphatase calcium phosphate product and the formation of vascular calcification (r=0.503,0.281,0.519,0.542,0.451,P<0.05).Conclusion Calcification of the radial artery is common in uremic patients,and there is a significant correlation between serum phosphorus,vascular calcification rate,alkaline phosphatase and calcium phosphorus product and the formation of calcification of the radial artery in uremic patients. 2019 Vol. 26 (16): 95-97 [Abstract] ( 64 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 98 Clinical effect of Calcium Hydroxybenzenesulfonate combined with Yishen Huashi Granules in the treatment of chronic nephritis TANG Chong-yu Objective To investigate the clinical effect of Calcium Hydroxybenzenesulfonate combined with Yishen Huashi Granules in the treatment of patients with chronic nephritis.Methods A total of 60 patients with chronic nephritis proteinuria treated in our hospital from January 2015 to December 2017 were selected as the subjects.The patients were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group received routine comprehensive treatment.The observation group was supplemented with Yishen Huashi and Calcium Hydroxybenzenesulfonate on the basis of the control group.The 24-hour urine protein quantitation and clinical treatment effects of the two groups were recorded and compared.Results After treatment,the 24-hour urine protein quantitation,serum creatinine and blood urea nitrogen in the observation group were lower than those in the control group,and serum albumin was higher than that in the control group (P<0.05).The total clinical effective rate of the observation group was higher than that of the control group (P<0.05).Conclusion Yishen Huashi combined with Calcium Hydroxybenzenesulfonate in the treatment of chronic nephritis proteinuria patients can effectively reduce the 24-hour urine protein quantitation,reduce proteinuria excretion,and effectively improve the clinical treatment effect of patients. 2019 Vol. 26 (16): 98-100 [Abstract] ( 78 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 101 Effect comparison of two-micron laser prostate vaporization enucleation and transurethral bipolar plasma prostatectomy in the treatment of large benign prostatic hyperplasia MA En-hui； XU Tao； GUO Zhen-jia； GU Yu-feng； WU Kai-da； LIANG Zhong-cheng； Objective To compare the clinical effect of two-micron laser prostate vaporization enucleation and transurethral bipolar plasma prostatectomy in the treatment of large benign prostatic hyperplasia.Methods A total of 110 patients with large benign prostatic hyperplasia who were treated in our hospital from May 2017 to May 2018 were selected as the subjects.They were divided into control group (transurethral bipolar plasma prostatectomy)and observation group(two-micron laser prostate vaporization enucleation)by the random number table method,with 55 cases in each group.The clinical indicators of the two groups were compared.Results After treatment,the postoperative hospital stay,indwelling catheter time and bladder irrigation time in the observation group were shorter than those in the control group,with statistical significances(P<0.05).The hemoglobin level 1 h after surgery in the observation group was higher than that of the control group,with a statistical difference (P<0.05).There were no significant differences in the operation time,prostate volume,residual urine volume,maximum urinary flow rate and international prostate symptom scores in the observation group compared with those of the control group (P>0.05).Conclusion The two-micron laser prostate vaporization enucleation can effectively improve the prognosis of patients with large benign prostatic hyperplasia.It is tantamount to transurethral bipolar plasma prostatectomy and is worthy of promotion. 2019 Vol. 26 (16): 101-103 [Abstract] ( 85 ) HTML (33 KB)  PDF  (0 KB)  ( 14 ) 104 Effect comparison of peritoneal dialysis and hemodialysis in the treatment of end-stage diabetic nephropathy SHI Yan-chun Objective To compare the effect of peritoneal dialysis(PD)and hemodialysis(HD)in the treatment of endstage diabetic nephropathy.Methods A retrospective analysis was conducted in 75 patients with end-stage diabetic nephropathy who were treated in our hospital from January 2011 to December 2017.According to the different dialysis methods,they were divided into PD group and HD group,including 38 patients in PD group and 37 patients in HD group.The clinical efficacy,blood lipid changes and adverse reactions of the two groups of patients after 1 year of treatment were compared.Results The serum creatinine(SCr),urea nitrogen(BUN),24 h urine volume,and glomerular filtration rate(GFR)of the two groups were lower than those before treatment(P<0.05).The urine volume of 24 h in the PD group was higher than that of the control group,and the difference was statistically significant(P<0.05).The levels of triglyceride (TG)and low-density lipoprotein cholesterol(LDL-C)in the PD group were significantly higher than those before treatment and the control group (P<0.05).There were no significant differences in total cholesterol(TC)and high-density lipoprotein cholesterol(HDL-C)between the two groups before and after treatment(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion PD and HD are feasible and effective for patients with diabetic nephropathy and uremia,but have different effects on 24-hour urine volume and blood lipids.The dialysis method needs to be determined according to the specific conditions of the patients. 2019 Vol. 26 (16): 104-107 [Abstract] ( 69 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 108 Clinical effect of standard channel percutaneous nephrolithotomy under B-mode ultrasound combined with instantaneous X-ray localization in the treatment of non-nephredema renal calculi FENG Quan-yao; XU Xun; ZHANG Zhan-ying; HUANG Yi-heng; YANG Yun-jie; CUI Xue-jiang Objective To investigate the clinical effect of standard channel percutaneous nephrolithotomy(PCNL)under B-mode ultrasound combined with instantaneous X-ray localization in the treatment of non-nephredema renal calculi.Methods Eighty-six patients with non-nephredema renal calculi admitted to our hospital from February 2016 to October 2018 were randomly divided into study group and control group,with 43 cases in each group.The standard channel PCNL was located by B-mode ultrasound combined with instantaneous X-ray in the study group,and the standard channel PCNL was located by B-mode ultrasound in the control group.The time of channel establishment,operation time,hospitalization time,primary stone clearance rate and complications were compared between the two groups.Results The time of channel establishment and operation in the study group was shorter than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in hospitalization time between the two groups(P>0.05).The stone clearance rate of the study group was 90.7%,which was higher than 74.4%of the control group,the difference was significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups (P>0.05).Conclusion Standard channel PCNL under B-mode ultrasound combined with instantaneous X-ray localization in the treatment of non-nephredema renal calculi can shorten the time of establishing percutaneous renal channel and operation,with high stone clearance rate,which is worthy of clinical promotion. 2019 Vol. 26 (16): 108-111 [Abstract] ( 62 ) HTML (36 KB)  PDF  (0 KB)  ( 13 ) 112 Clinical effect of acupuncture combined with traditional Chinese medicine triple sequential therapy on senile knee osteoarthritis OU Zhi-jian Objective To explore the clinical effect of acupuncture combined with triple sequential therapy of traditional Chinese medicine in the treatment of senile knee osteoarthritis.Methods From February 2018 to January 2019,80 elderly patients with knee osteoarthritis treated in our hospital were selected as the subjects.They were divided into observation group and control group according to the principle of random control,with 40 cases in each group.The control group received conventional clinical rehabilitation treatment,and the observation group added acupuncture combined with traditional Chinese medicine triple therapy sequential treatment on this basis.Before and 2 weeks after the intervention,the patients were evaluated by knee osteoarthritis severity index(ISOA)and the efficacy was evaluated.Results After treatment,the ISOA scores of the observation group were significantly lower than those of the control group(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Acupuncture combined with traditional Chinese medicine is effective in the treatment of osteoarthritis of the knee joint in the elderly.It can be used in clinical treatment and has popularization value. 2019 Vol. 26 (16): 112-114 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 115 Effect of bone transfer technique in the treatment of infectious nonunion of large femoral shaft HONG Yong-jun; ZENG Cheng-guan; LIN Qiu-yu; RUAN Cai-zheng; OUYANG Si-qiang Objective To investigate the effect of bone transfer technique in the treatment of infectious nonunion of large femoral shaft.Methods From October 2015 to October 2018,40 patients with massive infectious nonunion of femoral shaft in our hospital were selected and divided into the control group (n=20)and the study group (n=20)according to random number table method.The patients in the control group were treated with routine operation,and the patients in the study group were treated with bone transfer technique.The therapeutic effect,bleeding volume,operation time,hospitalization time and complication rate were compared between the two groups.Results The total effective rate of the study group was 95.00%,which was higher than that of the control group (65.00%),with significant difference (P＜0.05).The total incidence of complications in the study group was 5.00%,which was lower than that in the control group(30.00%),the difference was statistically significant(P＜0.05).The amount of bleeding in the study group was less than that in the control group,and the operation time and hospitalization time in the study group were shorter than those in the control group,the difference was statistically significant(P＜0.05).Conclusion The bone transfer technique is effective in the treatment of large segment of infectious nonunion of the femoral shaft.This technique can not only obtain ideal curative effect,but also reduce the operation time and the amount of bleeding,and prevent the occurrence of complications,make the patient recover better and faster. 2019 Vol. 26 (16): 115-117 [Abstract] ( 68 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 118 Effect of channel-tendon overall syndrome differentiation in the treatment of knee osteoarthritis CHEN Yu; WU Xuan; LI Zheng Objective To explore the effect of channel-tendon overall syndrome differentiation in the treatment of knee osteoarthritis(KOA).Methods A total of 80 patients with KOA treated in our hospital from February 2016 to February 2018 were enrolled in the study.They were divided into the observation group (40 cases)and the control group(40 cases)according to the number of hospitalization numbers.The observation group was treated with channel-tendon overall syndrome differentiation,and the control group was treated only at the knee tendon.The degree of pain,knee joint function,clinical symptoms,signs score and curative effect were compared between the two groups.Results After treatment,the knee joint score(HSS)of the observation group was higher than that before treatment,and the difference was statistically significant(P＜0.05).The HSS score of the observation group after treatment was higher than that of the control group,and the difference was statistically significant(P＜0.05).The visual analogue scale (VAS)score and symptom scores after treatment in both groups were lower than those before treatment,the differences were statistically significant(P＜0.05).The VAS and symptom scores of the observation group after treatment were lower than those of the control group,and the difference was statistically significant(P＜0.05).The total effective rate of the observation group(97.50%)was higher than that of the control group (82.50%),and the difference was statistically significant(P＜0.05).Conclusion Application of channel-tendon overall syndrome differentiation in the treatment of KOA can effectively improve the treatment effect,relieve pain,and improve the knee function,which is worthy of promotion and application. 2019 Vol. 26 (16): 118-121 [Abstract] ( 76 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 122 Causes and preventive measures of malunion and nonunion after internal fixation of limb fractures CHEN Yin-qin; WANG Shan-lin; HUANG De-quan Objective To investigate the causes of malunion and nonunion after internal fixation of limb fracture.Methods A total of 40 patients with malunion and nonunion after limb internal fixation in our hospital from June 2014 to June 2018 were selected as the study subjects,the causes and prevention measures were analyzed.Results The main causes of malunion and nonunion after internal fixation of limb fractures were excessive fracture injury,anatomical characteristics of fracture site,postoperative infection,implant materials and functional exercises.The total effective rate of treatment for patients with malunion and nonunion was 90.00%.Conclusion There are many factors affecting the occurrence of malunion and nonunion after internal fixation of limb fractures.Strengthening prevention and rapid diagnosis and treatment after operation can promote rapid healing and accelerate the recovery time of patients. 2019 Vol. 26 (16): 122-124 [Abstract] ( 85 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 125 Clinical effect of minimally invasive surgery under lumbar foramen endoscopy in the treatment of lumbar disc herniation XIANG Dong-gang Objective To investigate the clinical effect of minimally invasive surgery under lumbar foramen endoscopy in the treatment of lumbar disc herniation.Methods A total of 60 patients with lumbar disc herniation admitted to our hospital from October 2016 to October 2018 were selected as the research objects.According to the random number table method,they were divided into the control group(30 cases)and the minimally invasive group(30 cases).The control group was treated with routine open surgery via posterior approach,and the minimally invasive group was treated with minimally invasive surgery under lumbar foramen endoscopy.The patients were followed up for 2 months.The operation time,amount of bleeding during operation,the time of leaving bed after operation,the visual analogue scale(VAS)score of pain before and after before and 1 week after operation,the incidence of complications during hospitalization,Fugl-Meyer lower extremity score and Oswestry dability index(ODI)score of lumbar before and 2 months after operation were compared between the two groups.Results The length of operation,the time of leaving bed after operation in the minimally invasive group were shorter than those in the control group,the amount of bleeding during operation in the minimally invasive group was less than that in the control group,and the VAS score in the first week after operation in the minimally invasive group was lower than that in the control group,the difference was statistically significant(P＜0.001).The incidence of complications in the minimally invasive group was 3.33%,which was significantly lower than that in the control group(20.00%),the difference was statistically significant(P＜0.05).The Fugl-Meyer lower limb score of the minimally invasive group at 2 months after operation was significantly higher than that of the control group,and the ODI score of the minimally invasive group at 2 months after operation was significantly lower than that of the control group,the difference was statistically significant(P＜0.001).Conclusion In the treatment of patients with lumbar disc herniation,minimally invasive surgery with lumbar foramen endoscopy has the advantages of short operation time,less trauma,less bleeding,less complications and less pain,which is beneficial to the recovery of lower limb function and lumbar function.The effect is ideal. 2019 Vol. 26 (16): 125-127转131 [Abstract] ( 69 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 128 Clinical effect of distal cutaneous branch flap of dorsal metacarpal artery for repairing soft tissue defects of fingers YAO Keng LIANG Jun-feng TAN Yu-shun Objective To explore the effect of the cutaneous branch of distal palm-back artery flap in repairing soft tissue defects of fingers.Methods A total of 62 patients with finger soft tissue defect accepted in our hospital from March 2015 to March 2016 were selected as the subjects,and randomly divided into two groups,with 31 cases in each group.The control group received lateral flap repair,and the observation group received dorsal metacarpal artery flap repair.The clinical effects of the two groups were compared.Results The operation time and healing time of the observation group were shorter than those of the control group,the amount of bleeding was less than that of the control group,and total incidence of complications of the observation group were lower than that of the control group(P<0.05).The healing rate,survival rate,TAM hand function score,mental health score and social function score of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in body pain score between the two groups(P>0.05).Conclusion The cutaneous branch of distal palm-back artery flap has significant effect in repairing soft tissue defects of fingers,and it is worthy of clinical promotion. 2019 Vol. 26 (16): 128-131 [Abstract] ( 68 ) HTML (37 KB)  PDF  (0 KB)  ( 11 ) 132 Comparison of minimally invasive acromioclavicular and coracoclavicular ligament reconstruction and clavicular hook plate fixation treating acromioclavicular joint dislocation HUANG Cong-wu; CHEN Ke-ming Objective To compare the effect of minimally invasive acromioclavicular and coracoclavicular ligament reconstruction and clavicular hook plate fixation treating acromioclavicular joint dislocation.Methods Sixty patients with acromioclavicular joint dislocation admitted to our department from May 2017 to February 2018 were randomly divided into the two groups.In the control group,clavicular hook plate fixation was used,while in the observation group,mitek repair with acromioclavicular and coracoclavicular ligament reconstruction in minimally invasive small incision was adopted.The surgical effect,various surgical indexes and incidence of complication of patients between the two groups were compared.Results The excellent and good rate of Karksson score in the observation group was 96.67%one month after operation,which was significantly higher than that in the control group(80.00%)(P<0.05).The operation time and hospital stay of the observation group were greatly shorter than those of the control group,the amount of bleeding during operation was significantly less than that of the control group,the VAS pain score of the first day after operation was significantly lower than that of the control group,and the Constant-Murley score of the last follow-up was significantly higher than that of the control group (P<0.05).The total incidence of complications including postoperative periodontitis,acromial impingement,subacromial bone erosion,and re-dislocation of acromioclavicular joint was lower than that of the control group (P<0.05).Conclusion Minimally invasive acromioclavicular and coracoclavicular ligament reconstruction is more better treating acromioclavicular joint dislocation,which obviously improves the shoulder joint function at advantages of reliable ligament healing and low complication rate,and has positive clinical significance. 2019 Vol. 26 (16): 132-134 [Abstract] ( 61 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 135 Clinical effect of distal tibial locking compression plate in the treatment of complex Pilon fracture ZHANG Wen-ge； YANG Lin； LIANG Xi-zhang Objective To investigate the clinical effect of distal tibial locking compression plate in the treatment of complex Pilon fracture.Methods A total of 60 patients with complex Pilon fracture (excluding typeⅠPilon fracture)admitted to our hospital from June 2015 to June 2018 were selected and randomly divided into the observation group(30 cases)and the control group (30 cases).Both groups were given continuous combined spinal-epidural anesthesia.The control group was treated with anatomical compression plate internal fixation.The observation group was treated with distal tibial locking compression plate internal fixation.The operative effect,operation time,recovery time,hospitalization time and complications (incision infection,skin necrosis,ankle swelling,ankle stiffness,delayed fracture healing)were compared between the two groups.Results The total effective rate in the observation group was 95.5%,which was significantly higher than that in the control group (77.8%),the difference was statistically significant(P＜0.05).The operation time,recovery time and hospitalization time in the observation group were shorter than those of the control group,the difference was statistically significant(P＜0.05).The incidence rate of complication in the observation group was 8.8%,which was significantly lower than that in the control group (26.7%),the difference was statistically significant(P＜0.05).Conclusion The treatment of complex Pilon fracture with locking compression plate of distal tibia has remarkable curative effect,with fewer complications and quick recovery after operation.It is worth popularizing and applying in clinic. 2019 Vol. 26 (16): 135-137转141 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 138 Retrospective analysis of G6PD screening results in newborns in Jiangmen City YANG Ying-song； YANG Mei； ZHONG Zhi-lai； LI Zhi-ming； LIU Ying-yan； LI Ya-zhen； FENG Jian-jiang ； TANG Jia Objective To investigate the incidence of G6PD deficiency in newborns in Jiangmen City,and to analyze the reliability of fluorescence quantitative method for screening G6PD deficiency.Methods Fluorescent quantitative screening of 73183 newborns born from January 2017 to September 2018 for G6PD deficiency was carried out.The patients who were positive for fluorescence quantitative screening were recalled and re-diagnosed by enzyme or gene detection,and the three diagnostic results were compared.Results A total of 73 183 newborns(38 240 males and 34 943 females)were screened,and 3027 cases(2632 males and 395 females)were positive.The overall screening positive rate was 4.14%(3027/73 183).The positive rates of male and female screening were 6.88%(2632/38 240)and 1.13%(395/34943),respectively.The coincidence rate between fluorescence screening and enzymatic diagnosis was 96.57%(367/380),in which the coincident rates of male and female were 98.56%(343/348)and 75.00%(24/32)respectively.The coincidence rate between fluorescence quantitative method and gene detection was 92.98% (212/228).The coincident rates of male and female were 96.23%(153/159)and 85.51%(59/69),respectively.The coincidence rate of gene detection and enzyme activity was 89.22%(149/167),and the coincidence rate of male and female was 100.00%(112/112)and 67.27%(37/55),respectively.Conclusion Our city is a high incidence area of G6PD deficiency.At present,the fluorescence quantitative screening method can screen most male patients and female homozygotes,but the sensitivity to female heterozygotes is not high.Enzyme activity and gene detection should be carried out at the same time for suspicious children with positive screening and highly suspected clinically. 2019 Vol. 26 (16): 138-141 [Abstract] ( 77 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 142 Effect of microdissection testicular sperm extraction on the function in patients with azoospermia SHEN Yan； LI Qiang； WANG Jin-bao； ZHAO Li-jiang； YANG Wen-jie； HUANG Xiang； WU Xue-qing Objective To investigate the change of serum sex hormone levels and the sexual function in patients with azoospermia after microdissection testicular sperm extraction.Methods Seventy patients with azoospermia who underwent microsurgery from May 2016 to December 2017 were selected,by using the self-control method,the serum sex hormone levels and the sexual function of patients were compared before and after microdissection testicular sperm extraction.Results The luteinizing hormone (LH)and follicle stimulating hormone(FSH)levels and serum total testosterone(TT)and testosterone secretion index(TSI,TSI=TT/LH)and free testosterone index(FTI,FTI=TT/SHBG)values and international index of erectile function-5 (HEF-5)had not a significant difference compared with before operation(P＞0.05).Conclusions Microdissection testicular sperm extraction has little effect on testicular function in patients with azoospermia. 2019 Vol. 26 (16): 142-144 [Abstract] ( 59 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 145 Clinical effect of Low Molecular Weight Heparin in the treatment of recurrent spontaneous abortion and its influence on immune function and hormone levels LIN Zhi-jin； YANG Xiu-zhen； ZHANG Jiong-lan； CHEN Jian-ying； LIN Xiao-tao； CHEN Liang-wan Objective To explore the clinical effects of Low Molecular Weight Heparin combined with traditional placenta therapy in the treatment of patients with recurrent spontaneous abortion and its influence on immune function and hormone levels.Methods A total of 204 patients with recurrent spontaneous abortion who admitted to our hospital from February 2016 to March 2017 were selected as the research objects.According to the random number table method,the patients were divided into the control group(102 cases)and the study group(102 cases).The control group was treated with traditional placenta therapy,while the study group was treated with Low Molecular Weight Heparin as adjuvant therapy on the basis of the control group.Pregnancy outcomes,the level of serum estradiol(E2),human chorionic gonadotropin(HCG),progesterone(P),interleukin-4(IL-4),interferon-γ (IFN-γ),IFN-gamma/IL-4 and adverse reactions were compared between the two groups.Results The success rate of fetal protection in the study group was 88.24%,which was higher than that in the control group(59.80%),and the difference was statistically significant(P＜0.05).The level of IFN-γ and IFN-γ/IL-4 in the study group after intervention were lower than those in the control group,and the difference was statistically significant(P＜0.05).The levels of IL-4,HCG,P,and E2in the study group after intervention were higher than those in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Recurrent abortion with traditional placenta therapy combined with Low Molecular Weight Heparin treatment can significantly improve the success rate of fetal protection,improve the body hormone level and immune function,and the incidence of adverse reactions is low. 2019 Vol. 26 (16): 145-147 [Abstract] ( 73 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 148 Clinical analysis of pregnancy outcome in pregnancy-induced hypertensive disease complicated with intrahepatic cholestasis of pregnancy XI Qun； LIU Hai-hua； CHEN Qiu-lian； YANG Qiu-juan Objective To explore the effect of pregnancy-induced hypertension combined with intrahepatic cholestasis of pregnancy on pregnancy outcome.Methods A total of 31 patients with gestational hypertension complicated with intrahepatic cholestasis during pregnancy were selected as the study group from December 2016 to December 2017,and 31 healthy pregnant women who came to our hospital for pregnancy examination during the same period were selected as the control group.Pregnancy outcomes and perinatal complications of the two groups were compared.Results The incidence of adverse pregnancy outcomes of premature rupture of membranes,cesarean section,preterm delivery and cloudy amniotic fluid in the study group were higher than that in the control group,and the differences were statistically significant(P<0.05).The total incidence of perinatal complications in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Pregnancy-induced hypertension and intrahepatic cholestasis of pregnancy can increase the incidence of maternal adverse pregnancy,which not only threatens the life of pregnant women but also affects the safety and health of perinatal children.Therefore,pregnant women who have this condition should be clinically performed.Active and effective treatment to reduce the incidence of adverse pregnancy outcomes. 2019 Vol. 26 (16): 148-150 [Abstract] ( 76 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 151 Application of healthcare failure modeand effect analysis in neonates with peripherally inserted central catheters LI Hai-xiang； XIONG Feng-xia； LI Xiao-cui； LIU Shu-xia； WANG Xia Objective To improve the application effect of healthcare failure modeand effect analysis (HFMEA)in neonates with peripherally inserted central catheters(PICC).Methods From March 2016 to February 2017,74 neonates treated by NICU in Gaoming District People′s Hospital of Foshan City were selected as the control group,and they were given routine PICC nursing program,while 76 neonates from March 2017 to February 2018 treated were selected as the observation group,and the potential risk was analyzed by HFMEA,the high-risk process was screened out and improved.The incidence of puncture site infection and catheter-related bloodstream infection (CRBSI),the daily incidence of CRBSI catheter and the average days of PICC catheter use were compared between the two groups.Results The incidence of puncture site infection,the incidence of CRBSI and the daily incidence of CRBSI catheter in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The average number of days used for PICC catheter in observation group was longer than that in control group,and the difference was statistically significant(P<0.05).Conclusion The application of HFMEA in strengthening the management of PICC CRBSI in neonates can effectively reduce the incidence of catheter-related infections and prolong the effective use time of PICC catheters,which is worthy of further promotion in clinic. 2019 Vol. 26 (16): 151-154 [Abstract] ( 70 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 155 Diagnostic value of conventional abdominal ultrasound combined with vaginal ultrasound in cesarean scar pregnancy LIN Xue-ru Objective To explore the diagnostic value of conventional abdominal ultrasound combined with vaginal ultrasound in cesarean scar pregnancy (CSP).Methods A total of 86 cases of early pregnancy after cesarean section in our hospital from June 2017 to June 2018 were selected as the research objects,they were randomly divided into the observation group(43 cases)and the control group(43 cases).The observation group was examined by conventional abdominal ultrasound combined with transvaginal ultrasound,while the control group was examined by conventional abdominal ultrasound.The cystic pregnancy,missed diagnosis type and recognition of ultrasound diagnosis were compared between the two groups.Results The diagnostic accuracy rates of cystic pregnancy and mixed mass pregnancy in the observation group were higher than those in the control group,with significant difference (P＜0.05).The scores of patients′satisfaction with diagnosis and doctors′evaluation of diagnosis process in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).The sensitivity and specificity of the observation group were higher than those of the control group,with significant difference(P＜0.05).Conclusion Abdominal ultrasound combined with vaginal ultrasound in the diagnosis of CSP after cesarean section can make more accurate diagnosis,and further reduce misdiagnosis and missed diagnosis. 2019 Vol. 26 (16): 155-157 [Abstract] ( 76 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 158 Clinical study on pelvic floor bioelectric stimulation to promote postpartum lactation and uterine involution NIE Ying； MAO Zhong-ying； FENG Hong； HUANG Dong-mei Objective To observe the effect of pelvic floor bioelectric stimulation on postpartum lactation and uterine involution,and to explore the clinical application value.Methods A total of 180 primiparas from 20 to 40 years old with no gestational co-morbidities and complications who gave birth to full-term infants from March 2015 to January 2017 in Women and Children′s Hospital in Nanhai District of Foshan City were selected as the study subjects.The prospective randomized method was used to divide the patients into study group A,study group B and control group,with 60 cases in each group.Patients in the control group were given postpartum routine nursing care,patients in the study group were given different treatment protocols using bioelectric technique on the basis of the control group(surface projection of the uterus body+sacrococcygeal region in group A,surface projection of bilateral uterine horn+surface projection of uterine body+sacrococcygeal region).The height of uterus fundus,the condition of lactation and uterine involution by ultrasound examination were compared.Results The uterus in the study group A was smaller than that in the study group B at 42 days after birth,and the difference between groups was statistically significant(P<0.05).The uterus in the study group A was smaller than that in the control group at 42 days after birth,and the difference between groups was statistically significant(P<0.05).The uterus in the study group B was smaller than that in the control group 42 days after birth,and the difference between groups was statistically significant(P<0.05).The change rate of uterine height at 72 hours after delivery was compared between the study group A,study group B and control group,there was no statistically significant difference between the three groups (P>0.05).The postpartum lactation adequacy rate and the postpartum 24 h lactation function score in the study group A were higher than those in the control group,and the differences were statistically significant(P<0.05).The postpartum lactation adequacy rate and the postpartum 24 h lactation function score in the study group B were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the postpartum lactation adequacy rate and postpartum 24 h lactation function score between the study group A and study group B (P>0.05).Conclusion Early application of bioelectric technique at 2 h after delivery can promote postpartum uterine involution and promote early lactation. 2019 Vol. 26 (16): 158-160转164 [Abstract] ( 66 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 161 Infection rate of group B hemolytic streptococcus in middle and late pregnant women and its effect on maternal and fetal outcomes DU Cai-rong； HU Jin； LUO Jian-ting Objective To investigate the infection risk of group B hemolytic streptococcus in middle and late pregnant women and its effect on the maternal and fetal outcomes.Methods By a random simple sampling,217 women in the middle and late pregnancyfor regular pregnancy tests were enrolled from March to December in 2017 in the department of obstetrics and gynecology in our hospital.The colloidal gold chromatography was used for group B hemolytic streptococcus detection,and the infection rate of group B hemolytic streptococcus was analyzed.After that,22 pregnant women with positive group B hemolytic streptococcus infection were enrolled as observation group,and the remaining 195 pregnant women with negative group B hemolytic streptococcus infection were as control group.The infection rate of group B hemolytic streptococcus,pregnancy outcomes including incidence of premature rupture of membranes,premature delivery,and fetal distress,and neonatal outcomes including incidence of neonatal infection,premature infant,and neonatal asphyxia in the two groups were compared.Results Twenty-two of the 217 patients were infected with group B hemolytic streptococcus,accounting for 10.1%.The infection rate of group B hemolytic streptococcus in≥30-year-old pregnant women was significantly higher than that in pregnant women less than 30 years old,and the difference was statistically significant(P<0.05).The incidence of premature rupture of membranes,premature delivery and fetal distress in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of neonatal infection in the observation group was higher than that in the control group,and the incidence of neonatal jaundice,premature infant and neonatal asphyxia were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Infection of group B hemolytic streptococcus in middle and late pregnant women can lead to adverse pregnancy outcomes such as premature delivery,premature rupture of membranes,and neonatal infection.It is necessary to standardize treatment interventions to improve pregnancy outcomes. 2019 Vol. 26 (16): 161-164 [Abstract] ( 80 ) HTML (36 KB)  PDF  (0 KB)  ( 13 ) 165 Effect of different delivery modes on ultrasound parameters and myoelectric value of pelvic floor structure in early postpartum primipara CHEN Mian-hong； CAI Min-lan Objective To explore the effect of different delivery modes on ultrasound parameters and myoelectric value of pelvic floor structure in early postpartum primipara.Methods A total of 129 primipara who were hospitalized in our hospital from January 2017 to March 2018 were selected as subjects.They were divided into selective cesarean section group(62 cases)and natural delivery group(67 cases)according to different modes of delivery,and 45 healthy uncultivated women were selected as the control group at the same time.All subjects were given the pelvic floor ultrasonography.The ultrasonic measurement parameters included urethral tilt angel(UTA),posterior ureterovesical angel(PUA),bladder neck position (BNP)and cervical mouth position (CMP)and urethral rotation angel(URA),bladder neck descent(BND),cervix down distance (CDD)were calculated.The values of pelvic floor electromyography of primipara were measured at the period of before delivery,6 weeks and 3 months after delivery respectively.Results At rest,the BNP in the selective cesarean section group and the natural delivery group was significantly lower than that in the control group,the CMP in the natural delivery group was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).In the maximum Valsalva state,the BNP of the selective cesarean section group and the natural delivery group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The UTA in the natural delivery group was significantly higher than that in the other two groups,the BNP and CMP were significantly lower than those in the other two groups,and the differences were statistically significant(P<0.05).The URA and BND of the natural delivery group were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).The sEMG peak,vitality and velocity values of the selective cesarean section group and the natural delivery group at 6 weeks after delivery were significantly lower than those before delivery,and the differences were statistically significant(P<0.05).The sEMG peak,vitality and velocity values of the natural delivery group at 6 weeks and 3 months after delivery were significantly lower than those in the selective cesarean section group,and the differences were statistically significant(P<0.05).Conclusion The mode of delivery has little effect on the ultrasound parameters of pelvic floor structure in primipara,and the effect of selective cesarean section on early electromyography is smaller than that of natural delivery. 2019 Vol. 26 (16): 165-168转172 [Abstract] ( 73 ) HTML (42 KB)  PDF  (0 KB)  ( 12 ) 169 Clinical characteristics analysis of late pregnancy electrocardiogram in elderly pregnant women with gestational diabetes mellitus XU Shao-yong; YOU Hai-ying Objective To explore the clinical characteristics of electrocardiogram(ECG)in late pregnancy of elderly pregnant women with gestational diabetes mellitus,and to provide guidance for clinical practice.Methods A total of 120 pregnant women with gestational diabetes mellitus(with gestational age of 28-41 weeks)admitted to our hospital from July 2016 to July 2018 were randomly selected as the observation group.The pregnant women in the observation group were divided into the elderly group(>35 years old,60 cases)and the appropriate age group(≤35 years old,60 cases)according to different ages,and another 60 cases of normal pregnant women who came to our hospital for the product inspection during the same period were selected as the control group.The total incidence rate of ECG abnormalities(arrhythmia,ST-segment change,low voltage,left-axis,short P-R interval),fasting blood glucose level and glycosylated hemoglobin level were compared in the observation group and the control group,the elderly group and the appropriate age group.The relationship between the age of pregnant women with gestational diabetes mellitus and the incidence rate of ECG abnormalities,fasting blood glucose level and glycosylated hemoglobin level was analyzed.Results The total incidence rate of ECG abnormalities in the observation group(36.67%)was significantly higher than that in the control group (10.00%),and the difference was statistically significant(P<0.05).The levels of fasting blood glucose and glycosylated hemoglobin in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Among the pregnant women in the observation group,the total incidence rate of ECG abnormalities in the elderly group (50.00%)was higher than that in the appropriate age group (23.33%),and the difference was statistically significant(P<0.05).The levels of fasting blood glucose and glycosylated hemoglobin in the elderly group were significantly higher than those in the appropriate age group,and the differences were statisti-cally significant(P<0.05).Correlation analysis showed that the age of pregnant women with gestational diabetes mellitus was moderate positively correlated with the incidence of ECG abnormalities,blood glucose level and glycosylated hemoglobin level(P<0.05).Conclusion Pregnant women with gestational diabetes mellitus have a higher incidence rate of ECG abnormalities in the late pregnancy,especially in elderly women.In order to ensure maternal and child safety,ECG should be carried out regularly for pregnant women. 2019 Vol. 26 (16): 169-172 [Abstract] ( 66 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 173 Study of changes of thyroid function in pregnant women with gestational diabetes mellitus GUO Yong-hui Objective To discuss the change of thyroid function in pregnant women with gestational diabetes mellitus.Methods A retrospective analysis was made on 90 pregnant women with gestational diabetes diagnosed from July 2017 to June 2018 in hospital,they were selected as the observation group.Another 100 pregnant women without complications of pregnancy in the same period were selected as the control group.The levels of triiodohyronine (T3),thyroxine(T4),free triiodothyronine(FT3),free thyroxine(FT4),thyraid-stinuslating hormore(TSH)and the positive rate of thyroperaseidase ourtibadies(TPOAb)in peripheral blood of the two groups were compared in early pregnancy,mid-pregnancy and late pregnancy.Results There was no significant difference in the levels of T3,T4,FT3,FT4,TSH and the positive rate of TPOAb between the two groups in early pregnancy(P＞0.05).In the second trimester of pregnancy,the level of T3and the positive rate of TPOAb in the observation group were significantly higher than those in the control group,with significant difference (P＜0.05).There was no significant difference in the level of T4,FT3,FT4and TSH between the two groups in the second trimester of pregnancy (P＞0.05).In the third trimester of pregnancy,the level of T4of the observation group was significantly lower than that of the control group,and the positive rate of TPOAb was significantly higher than that of the control group,with significant difference(P＜0.05).There was no significant difference in the level of T3,FT3,FT4and TSH between the two groups in the third trimester of pregnancy (P＞0.05).Conclusion The level of T3of gestational diabetes mellitus patients increases significantly in the second trimester,the level of T4decreases significantly in the third trimester,the positive rate of TPOAb is the highest in the second trimester,and the positive rate of TPOAb decreases in the third trimester,but still at a higher level. 2019 Vol. 26 (16): 173-176 [Abstract] ( 79 ) HTML (47 KB)  PDF  (0 KB)  ( 10 ) 177 Clinical effect of Bifidobacterium Tetrad Viable Tablets in the treatment of secondary diarrhea in children with pneumonia CHEN Yuan-ge Objective To explore the clinical effect of Bifidobacterium Tetrad Viable Tablets in the treatment of secondary diarrhea in children with pneumonia.Methods Forty children with pneumonia secondary diarrhea were selected from July to December 2018,they were divided into study group (n=20)and control group (n=20)by occult random grouping method.Both groups were given montmorillonite powder,on this basis,the research group took Bifidobacterium Tetrad Live Bacterial Tablets,the therapeutic effect,relief time and safety were compared.Results The total effective rate in the study group was higher than that in the control group,the remission time of clinical symptoms(nausea,vomiting,fever and abdominal pain)was shorter than that of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions was lower than that of the control group,but the difference had no statistical significance(P＞0.05).Conclusion Bifidobacterium Tetralogy Viable Tablets in the treatment of children with pneumonia secondary diarrhea can improve the therapeutic effect,accelerate the improvement of symptoms,reduce drug toxicity and side effects,it is worthy of clinical recommendation. 2019 Vol. 26 (16): 177-179 [Abstract] ( 61 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 180 Value of 64-slice CT coronary artery imaging in the diagnosis of occult coronary heart disease PENG Jiang-qiang； XIAO Pei-biao； MAI Yong-bin； ZHOU Xiao-juan Objective To study the value of 64-slice (computed tomography)CT coronary artery imaging in occult coronary heart disease(CHD).Methods A total of 58 patients with occult CHD who received treatments in our hospital from January 2016 to December 2018 were enrolled.All patients were performed with 64-slice CT coronary artery imaging.The diagnostic results of all patients were compared with the gold standard and the examinations were analyzed in details.Results The results of coronary angiography (CAG)were used as the gold standard.Among them,patients with mild stenosis accounted for 68.97%,and moderate stenosis for 31.03%.After comparison,the incidence of single coronary artery stenosis was 72.41%,and multiple was 27.59%,which was not displayed statistical difference between the 64-slice spiral CT and CAG (P＞0.05).After 64-slice spiral CT examinations in all participants,and there were 462 segments of coronary artery segment with a diameter of more than 2 mm.The image quality was observed after the patient′s examination.The image quality satisfied the clinical diagnosis accounted for 85.50%,and the rest was not qualified (14.50%),of which diagonal branch image was 21.43%,followed by the distal segment of left circumflex(20.59%),and the proximal segment of left circumflex (17.14%).The image quality of left main coronary artery can meet the clinical evaluation in a high proportion accounting for 90.91%,followed by the distal segment of left anterior descending branch (90.39%)and proximal segment of left anterior descending branch (89.66%).Conclusion For patients with suspected occult CHD,64-slice CT coronary artery imaging can be used for diagnosis,which benefits for timely diagnosis of coronary artery condition and plaque property,and actively improve patient′s prognosis.It is worthy of application. 2019 Vol. 26 (16): 180-182转192 [Abstract] ( 69 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 183 Clinical value of ultrasonography in screening fetal severe cardiac malformations at 11-13+6 weeks gestation +6 weeks gestation[J]. 中国当代医药, 2019,26(16): 183-185')" href="#"> HUANG Shu-xian; SHE Ling-na; ZENG Mei; LIU Li-na Objective To investigate the clinical value of prenatal ultrasound screening for fetal severe cardiac malformations at 11-13+6 weeks of gestation.Methods From January 2016 to December 2018,5128 pregnant women in the prenatal diagnosis center of our hospital were selected as the study subjects.The pregnant women were screened by NT ultrasound standardized structure at 11-13+6 weeks of gestation.All patients were screened for fetal heart with fourchamber(4CV)and three-vessel tracheotomy(3VVT).The results of severe cardiac malformations detected by the two methods alone and in combination were analyzed retrospectively.Results Among the 5128 pregnant women who underwent NT examination in our hospital since 11-13+6 weeks of gestation,the rates of obtaining 4CV,3VVT,4CV+3VVT by three methods were 91.56%,78.91%and 95.82%,respectively.A total of 26 cases of severe fetal heart malformations were examined,with the incidence of 0.5‰.Among them,14,7 and 22 cases of abnormal cardiac structure were detected by 4CV,3VVT and 4CV+3VVT respectively.The specificity of the three methods in the diagnosis of severe fetal heart malformation was similar,and there was no statistical difference (P＞0.05).The sensitivity of 4CV+3VVT in the diagnosis of severe fetal heart malformation was higher than that of the other two methods,but the rate of missed diagnosis was lower than that of the other two methods(P<0 05).Conclusion Prenatal ultrasound examination in pregnant women at 11 to 13+6 weeks of gestation is of great clinical value in screening for severe fetal heart deformities,especially,the combined screening of 4CV and 3VVT can effectively improve the diagnosis rate of severe cardiac malformations of fetus during the first trimester of pregnancy. 2019 Vol. 26 (16): 183-185 [Abstract] ( 70 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 186 Effect of eye acupuncture treating abducens nerve injury after brainstem stroke LI Xiao-quan; WANG Shu-juan; ZHANG Lei Objective To observe the effect of eye acupuncture treating abducens nerve injury after brainstem stroke.Methods All of 42 patients with abducens nerve injury after brainstem stroke from outpatient and inpatient department of the Shenyang Hunhe Integrated Traditional Chinese and Western Medicine Hospital from October 2015 to October 2017 were selected,and they were randomly divided into the treatment group(n=20)and control group(n=22).Patients in the two groups were given modern rehabilitation treatment,and the treatment group was treated with eye acupuncture additionally.10 consecutive times as a course of treatment,patients were treated for 4 courses.At the end of the second and fourth courses,the clinical effect between the two groups was compared.Results The total effective rate of the second course of treatment was not significantly different between the two groups (P=0.08),and the total effective rate of the fourth course of treatment was significantly different between the two groups (P=0.032).Conclusion Eye acupuncture therapy can significantly improve abducent nerve injury symptoms after brainstem stroke. 2019 Vol. 26 (16): 186-188 [Abstract] ( 63 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 189 Summary of professor HAO Xiao-bo′s experience of characteristic external therapy of traditional chinese medicine on ophthalmopathy CHEN Jin-hao; LIN Liu-yan; ZHONG Shu-yang; ZHANG Cai-xia; ZHAO Jian-ying; HAO xiao-bo Professor HAO Xiao-bo is a well-known expert in ophthalmology of traditional Chinese medicine in China,and he has been engaged in ophthalmology of traditional Chinese medicine for more than 30 years from watch,hear,ask and touch to regulating Ren Du meridians.In the external treatment of ophthalmopathy,he followed the theory of traditional Chinese ophthalmology and made some innovations and developments,with abundant experience,and gradually formed his own unique treatment method.Now the experience of external treatment of ophthalmopathy in TCM is summarized as four points:①Regulating Ren Du meridians and dredging meridians to improve immediate vision;②Acupoint catgut embedding combined with syndrome differentiation and skillful treatment of intractable uveitis;③Midnight-noon ebb-flow,eight methods of intelligent turtle for acupoint opening combined with acupuncture in the treatment of difficult ophthalmopathy;④Zhuang medicine medicated thread moxibustion treating eye disease. 2019 Vol. 26 (16): 189-192 [Abstract] ( 83 ) HTML (36 KB)  PDF  (0 KB)  ( 11 ) 193 Investigation of hearing loss in senile deafness and the effect evaluation of drug treatment ZHANG Bi-ru; CHEN Yong-ming; YANG Jia-ying; XU Jia-bao; LU Qiu-ping; ZENG Li-na Objective To understand the deafness or hearing impairment in the elderly who complained of hearing loss over 60 years old,and to explore the effectiveness of drug therapy.Methods Sixty patients with complaint of hearing loss admitted to our hospital from January to September 2018 were selected as the study subjects,all patients were examined by pure tone audiometry and acoustic immittance test.They were assessed according to the hearing loss classification established by the World Health Organization.The hearing thresholds of different age groups were investigated.The patients with hearing loss were treated with microcirculation improvement and neurotrophic therapy for 2 to 4 weeks,the pure tone hearing threshold level was tested after 1 month to evaluate the intervention effect.Results A total of 60 patients,54 had hearing loss in 105 ears,hearing loss is mainly concentrated in the mild,moderate,moderate and severe and severe stages with hearing threshold of 26-＜90 dB.There were significant differences in pure tone hearing thresholds between different age groups and different frequencies (P<0.05),which tended to increase with the increase of age.The total effective rate of drug treatment was 14.81%.Conclusion Elderly people over 60 years old mostly suffer from hearing loss in varying degrees,the degree of hearing loss increases with age,and the effect of drug treatment is not good. 2019 Vol. 26 (16): 193-195 [Abstract] ( 66 ) HTML (34 KB)  PDF  (0 KB)  ( 10 ) 196 Application effect of the dynamic appraisal of situational aggression in newly hospitalized psychiatric patient ZHANG Xiao-Chun; FANG Min; HE Yong; Gao Yun Objective To explore the application effect of dynamic violence risk assessment scale(DASA)on newly admitted psychiatric patients.Methods From April to September 2018,in the Baiyun Psychiatric Rehabilitation Hospital and The Mental Hospital of Guangzhou Civil Administration Bureau,360 newly admitted psychiatric patients were selected as the study subjects.According to the method of random number table,patients were divided into study group and control group,180 cases in each group.The study group was assessed the scores of all subjects with DASA,and then given the corresponding intervention measures.The control group did not use the DASA scale,according to the clinical experience of medical staff to give appropriate interventions.The incidence of violent injuries,the time of protective restraint and patient satisfaction were compared between the two groups.Results The incidences of violent injuries in the study group was lower than that in the control group,the protective restraint time was shorter than that of the control group,and the patients′satisfaction was higher than that in the control group,the differences were statistical significance(P<0.01).Conclusion The application of the DASA can effectively improve the accuracy of predicting violence in newly admitted psychiatric patients and reduce the potential violence of psychiatric inpatients.It helps to reduce the time of protective restraint,the satisfaction of the newly psychiatric patients is improved. 2019 Vol. 26 (16): 196-198 [Abstract] ( 64 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 199 Analysis of neonatal disease screening in Enshi from 2006 to 2016 XIE Ying; WANG Yong; XIANG Shi-gui; TIAN Fang-fang Objective To analyze the screening status,incidence and recall rate of congenital hypothyroidism(CH)and phenylketonuria (PKU)in Enshi Prefecture since the application of neonatal disease screening.Methods A retrospective analysis of neonatal disease screening data from 2006 to 2016 in Enshi Prefecture was conducted.Thyroid hormone(TSH)and Phenylalanine(PA)concentrations were measured by time-resolved immunofluorescence and immunofluorescence,respectively.Results From 2006 to 2016,a total of 290 973 neonates were screened by the Neonatal Disease Screening Center of Enshi Prefecture.The average positive detection rate of CH was 1∶2575,and the average positive detection rate of PKU was 1∶41 568.From 2006 to 2016,the number of screenings arose from 4508 to 33 271,and the screening rate increased from 15.82%to 94.43%.The positive rate of CH increased from 0 to 1∶2218.The positive rate of PKU increased from 0 to 1∶41 568.The screening rate and positive rate increased significantly over the ten years.The average recall rate of CH and PKU from 2006 to 2016 was 79.7%and 76.5%,respectively.The tendency of recall rate change was irregular.Conclusion The screening of newborn diseases in Enshi Prefecture is on the right track.In order to reduce the incidence of neonatal growth and metal development disorder,the management of neonatal disease screening should be strengthened.Also,early detection,diagnosis and treatment should be ensured. 2019 Vol. 26 (16): 199-201 [Abstract] ( 73 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 202 Review and analysis of prescriptions for Chinese medicine pieces in our hospital ZHANG Jing-yi; GUAN Sheng-jiang▲ Objective To analyze the problems existing in the prescriptions of Chinese medicine pieces,so as to promote its rational clinical application and improve the safety for patients.Methods A total of 1150 outpatient prescriptions for Chinese medicine pieces from January to September in 2018 were randomly selected from our hospital information system for statistical analysis.Results Among them,50 prescriptions were unreasonable,including large dose/error in 8 cases,accounting for 16%;inconsistence of drug and pattern in 23,accounting for 46%;inappropriate herbal medicine selection in 4 cases,accounting for 8%;special decoction without labeling in 5 cases,accounting for 10%;improper administration in 5 cases,accounting for 10%;the disease diagnosis being too general in 3 cases,accounting for 6%.The unqualified rate was 4.35%,and the qualified prescription rate was 95.65%.Conclusion The qualified rate of Chinese medicine pieces in our outpatient clinic is relatively high,but the doctors should pay attention to the nonstandard prescriptions.At the same time,the occupational study of pharmacist should be strengthened and the prescription review should be attached great importance in order to improve the professional and technical levels and ensure patients′safe,rational and effective medication. 2019 Vol. 26 (16): 202-204 [Abstract] ( 83 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 205 Analysis of usage rationality of anti-neoplastic drugs in pharmacy intravenous admixture services CAI Li; CHEN Wen-jing; XIAN Bao-zhen Objective To analyze the rationality of anti-neoplastic drugs in pharmacy intravenous admixture services(PIVAS)and reference for the safety and effectiveness of clinical antineoplastic drugs in the future.Methods A retrospective analysis was made on the prescriptions of 2000 groups of antineoplastic drugs prepared by PIVAS in our hospital from August 2014 to August 2017,according to the instructions of various anti-neoplastic drugs,referring to the relevant drug use standards(such as pharmacopoeia,newly compiled pharmacology,China National Prescription Collection,clinical intravenous drug dispensing and use guidelines),as well as the relevant warnings issued by the State Food and Drug Administration (CFDA)and the United States FDA,et al.The dosage and selection of solvents in prescriptions were counted,and the route,dosage,sequence and other irrational drug use of antineoplastic drugs were also counted.The choice of solvent,concentration and infusion time of common antineoplastic drugs were counted.The order of administration of antineoplastic drugs in combination was counted.Results A total of 127 out of 2000 prescriptions were unqualified,accounting for 6.35%,among them,unreasonable solvents accounted for 70.08%(89/127),which showed improper dosage and selection.The irrational rate of anti-neoplastic drugs was 22.05%(28/127),including irrational route of administration,irrational dosage and irrational order of administration.Other unreasonableness accounted for 7.09% (9/127).There were differences in the stability of solvents and liquids used in different antineoplastic drugs,so the clinical infusion time and precautions were different.There was a certain order of administration in the clinical application of antineoplastic drugs.If the order of administration was wrong,it would affect the anti-neoplastic effect of drugs or cause serious adverse reactions.Conclusion There are some unreasonable prescriptions in the use of PIVAS antineoplastic drugs,such as improper solvent dosage,improper selection,irrational route of administration,irrational dosage and irrational order of administration,et al.Hospitals need to strengthen the audit of the above issues to ensure the quality and rational use of antineoplastic drugs. 2019 Vol. 26 (16): 205-208 [Abstract] ( 66 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 209 Bibliometric analysis of nursing research related to mindfulness decompression therapy in China WANG Jing； XIE Xian-ping Objective To analyze the application status and development trend of our mindfulness decompression therapy in the field of nursing,and provide reference for future research in this field.Methods The related literatures on mindfulness decompression therapy was searched in China Knowledge Network (CNKI),Wanfang Database,China Biomedical Literature Database (CBM),PubMed,CINAHL,Science Direct,Wliey Online Library,and Web of science database.The search time limit was built.The library would be until September 30,2018,metrological analysis of standards-compliant literature.Results A total of 149 articles were included,and the first one was published in 2010.The total number of documents has increased year by year,with the majority of documents in Shandong,Jiangsu and Guangdong.A total of 29 articles were included in the core journals of nursing,accounting for 19.46%of the total number of documents;Most of the research types were clinical experimental research,and the subjects were mainly breast cancer patients;The outcome indicators that focus on anxiety were depression,perceived stress,negative emotions,cancer-related fatigue,and occupational stress.Conclusion Nursing research on mindfulness decompression in China has gradually received attention.The quality of research needs to be further improved,the depth of research fields and research content should be broadened,the types and forms of research design should be enriched,and the interventional plan for mindfulness decompression should be standardized to promote the in-depth application of mindfulness decompression therapy and promotion. 2019 Vol. 26 (16): 209-212转216 [Abstract] ( 75 ) HTML (41 KB)  PDF  (0 KB)  ( 8 ) 213 Screening for diabetic retinopathy in type 2 diabetic patients in Qindu District，Xianyang City WANG Fang; WANG Min; SONG Qiu-li; HOU Li-hua; LIU Hao; ZHAO Jin Objective To screen for diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM)diagnosed in Qindu District,Xianyang City.Methods From January to June 2017,101 patients with T2DM diagnosed in our hospital in Qindu District,Xianyang City were enrolled in the study.All patients were provided with fundus screening and questionnaire survey to study the prevalence of DR and its influencing factors.Results There were 101 diabetic patients with clear detection of fundus,including 27 cases of DR(26.7%).The prevalence of DR with disease duration≤5,＞5-10,＞10-15,＞15-20,and ＞20 years was 13.5%,34.8%,43.5%,9.1%,and 42.9%with statistical significance(P<0.05).The prevalence of diabetic patients with or without family history was 50%and 16.9%,respectively,which was statistically significant(P<0.05).The age of patients,the course of DM,and hypertension were closely related with DR.Conclusion The risk factors of DR in this survey are age,disease duration,and hypertension,which increase the awareness of DR and play an important role in controlling the occurrence and development of DR. 2019 Vol. 26 (16): 213-216 [Abstract] ( 81 ) HTML (37 KB)  PDF  (0 KB)  ( 11 ) 217 Application effect of continuity nursing in patients with chronic heart failure gallstone complicated with atrial fibrillation YANG Mu-lan; WEN Fang-fang; HU Hui-lian Objective To explore the effect of continuity nursing on patients with chronic heart failure(CHF)and atrial fibrillation gallstone with self-care behavior and external medication compliance.Methods All of 200 cases of patients with CHF and atrial fibrillation gallstone in our hospital from April 2015 to June 2018 were selected.According to random number table method,they were divided into the control group and the intervention group,100 cases in each group.Two groups of patients were told take medicine as prescribed when they left hospital,intervention group were given continuously nursing on the basis of control group,two groups patients self care ability and medication compliance and prognosis were compared.Results After discharge,the self-care ability score of the intervention group was significantly higher than that of the control group(P<0.05).The external medication total compliance of the intervention group was 85.00%,significantly higher than 65.00%of the control group(P<0.05),and the prognosis effect of the intervention group was significantly better than that of the control group(P<0.05).Conclusion To patients with CHF and atrial fibrillation gallstone were given continuous medical treatment.It can satisfied the patients self-care behavior and external medication compliancec needs when they left hospital,and improve the patients′behavior and medication adherence.This is meaningful and worth promoting further in clinic. 2019 Vol. 26 (16): 217-219 [Abstract] ( 70 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 220 Risk factors disscussion of acute pressure sore occcurence in patients with forced lateral prone position in operating room LIU Fang-lian Objective To investigate the risk factors of acute pressure sore in patients with forced lateral prone position in operating room.Methods From December 2017 to December 2018,105 patients with lateral position and prone position who underwent elective operation were selected as the subjects of study.The basic data of the patients and the related factors before operation were analyzed retrospectively,and the occurrence of acute pressure sore during operation was analyzed.The risk factors of acute pressure sore during operation were analyzed by single factor analysis and multivariate Logistic regression analysis.Results There were 12 cases of acute pressure sore in 105 patients,all of them were stageⅠpressure sore,and the incidence of acute pressure sore was 11.43%.Single factor analysis showed that age,body mass index(BMI),preoperative hemoglobin,intraoperative pressure,duration of operation and intraoperative protective measures were associated with the occurrence of acute pressure sore(P＜0.05),while multivariate Logistic regression analysis showed that BMI,preoperative hemoglobin,duration of operation and no protective measures during operation were risk factors for the occurrence of acute pressure sore(P＜0.05).Conclusion The occurrence of acute bedsore in patients with forced lateral prone position in operating room is related to BMI,preoperative hemoglobin,duration of operation and protective measures during operation.Therefore,intervention measures should be taken for related risk factors in order to reduce the incidence of surgical pressure sore. 2019 Vol. 26 (16): 220-222 [Abstract] ( 73 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 223 Effect of nursing intervention on psychological status and quality of life of tuberculosis patients ZHOU Qiu-hong; HUANG Ying-lian; XIE Shu-zhen Objective To explore the effect of nursing intervention on psychological status and quality of life of tuberculosis patients.Methods A total of 98 cases of pulmonary tuberculosis patients admitted to our hospital from May 2016 to April 2018 were selected as subjects.According to the random number table method,they were divided into control group and observation group,49 cases in each group.The control group was given routine nursing intervention,while the observation group was given comprehensive nursing intervention.The improvement of psychological status and quality of life of two groups of patients were compared after two different nursing methods.Results Before nursing,there was no significant difference in depression score and anxiety score between the two groups(P>0.05).After comprehensive nursing intervention,the depression score and anxiety score of the observation group were (14.73±2.16)ponits and (12.85±2.94)ponits respectively,which were significantly lower than those of the control group ([19.87±3.16],[18.90±3.74]ponits),the differences were statistically significant(P<0.05).Moreover,the life quality score of the observation group after nursing intervention was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the process of nursing for tuberculosis patients,comprehensive nursing intervention can not only significantly improve the negative psychological state of patients,but also improve their quality of life score and promote prognosis recovery,which is worthy of clinical reference and implementation. 2019 Vol. 26 (16): 223-226 [Abstract] ( 67 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 227 Application effect of operating room quality nursing mode in patients undergoing gastrointestinal surgery CHEN Wen-ting; FENG Hui-ting Objective To explore the influence of operating room quality nursing mode on wound healing and recovery,complications and nursing satisfaction of patients undergoing gastrointestinal surgery.Methods A total of 186 cases of gastrointestinal surgery patients admitted to our hospital from March 2016 to March 2018 were selected as the research objects.According to the random number table method,they were divided into experimental group and control group,with 93 cases in each group.The control group received basic nursing intervention in the operating room,and the experimental group gave high-quality nursing intervention in the operating room on the basis of basic measures.The wound healing,complication incidence and total nursing satisfaction of the two groups were compared.Results Surgical incision healing in the experimental group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).The total incidence of complications in the experimental group was 2.15%,higher than that in the control group(10.75%),and the difference was statistically significant(P<0.05).The total nursing satisfaction of patients in the experimental group was 96.77%,higher than that of the control group (75.27%),and the difference was statistically significant(P<0.05).Conclusion High quality nursing in the operating room significantly improved the wound healing rate of patients,significantly reduced complications,and patients'satisfaction with nursing services was higher. 2019 Vol. 26 (16): 227-229 [Abstract] ( 73 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 230 Effect of health education combined with pain nursing on the rehabilitation effect of children undergoing circumcision SHI Qi; CHI Cheng-tao; ZHANG Xiao-li; GE Wei-hua Objective To explore the influence of health education combined with pain nursing on the rehabilitation effect of children undergoing circumcision.Methods From January 2017 to July 2018,138 children circumcision in pediatric surgery of Hongqi Hospital Affiliated to Mudanjiang Medical College were selected as nursing objects from January 2017 to July 2018.The children were divided into control group and observation group according to random number table method,with 69 cases in each group.The children in the control group received routine nursing,while the children in the observation group received health education combined with pain nursing.The fear situation of the two groups was compared.The pain scores of the two groups were compared at different postoperative time(6,24,48 h after surgery).The total incidence of postoperative complications was compared between the two groups.Results The fear situation of children in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).At 24 and 48 h after surgery,the pain scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Health education combined with pain nursing was effective to improve the rehabilitation effect of children undergoing circumcision. 2019 Vol. 26 (16): 230-233 [Abstract] ( 77 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 234 Application effect of perioperative nursing cooperation in small incision thyroid surgery with endoscopy and ultrasound scalpel WEN Jun Objective To study on the value of perioperative nursing cooperation in small incision thyroid surgery with endoscopy and ultrasound scalpel.Methods A total of 52 patients who underwent thyroid surgery from December 2016 to December 2018 in our hospital were selected.According to the random number table method,they were divided into the experimental group and the control group,with 26 cases in each group.The control group was given routine nursing care,and the experimental group was given perioperative nursing care.The total degree of nursing satisfaction,anxiety score(SAS),depression score(SDS),operation time,hospitalization time,pain score,and the incidence rate of complication between the two groups were compared.Results The total degree of nursing satisfaction of the experimental group was higher than that of the control group(P＜0.05).The SAS and SDS scores of the two groups after nursing were lower than those before nursing,and the SAS and SDS scores of the experimental group after nursing were lower than those of the control group (P＜0.05).The operation time and hospitalization time of the experimental group were shorter than those of the control group (P＜0.05).The pain score and the incidence rate of complication in the experimental group were significantly lower than those in the control group (P＜0.05).Conclusion The application of perioperative nursing cooperation in small incision thyroid surgery with endoscopy and ultrasound scalpel can effectively improve patients′negative emotions and improve patients′nursing satisfaction,which is safe and effective,and has clinical application value. 2019 Vol. 26 (16): 234-236 [Abstract] ( 64 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 237 Effect of hand holographic acupoint combined with auricular acupoint pressing on patients with acute exacerbation of chronic obstructive pulmonary disease undergoing mechanical ventilation HU Cai-tian; WANG Min-zhu; PAN Zhi-ming; FENG Yan Objective To explore the effect of hand holographic acupoint combined with auricular acupoint pressing on mechanical ventilation patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Sixty patients with AECOPD and respiratory failure diagnosed in our hospital Department of critical care medicine from January 2016 to November 2017 were selected for mechanical ventilation.They were divided into observation group and control group according to random number table method,30 cases in each group.The control group was the routine treatment nursing group (condition observation,medicine,artificial airway,balloon,sputum suction,ventilator pipeline,oral cavity,off-line,psychological care)etc.The observation group was based on routine treatment and nursing combined with hand holographic acupoints and auricular acupoint pressing,and the respiratory frequency,oxygen saturation recovery time of the two groups of patients were compared;the time of off-machine and off-bed activity of the ventilator;the incidence and survival rate of atelectasis,pulmonary dysfunction,circulatory failure,ventilator-associated pneumonia were observed in observation group.Results Respiratory frequency and oxygen saturation returned to normal in the observation group;the time of off-line and out-of-bed activities of the ventilator was significantly shorter than that of the control group (P<0.05);the proportion of atelectasis,decreased pulmonary function,circulatory failure and ventilater associated pneamonia in the observation group was significantly lower than that of the control group,and the survival rate was significantly increased than that in the observation group (P<0.05).Conclusion Holographic hand acupoint pressing combined with ear acupoint pressing can promote the recovery of pulmonary function and improve the survival rate of AECOPD patients undergoing mechanical ventilation. 2019 Vol. 26 (16): 237-240 [Abstract] ( 63 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 241 Nursing effect of continuing nursing service on patients with central venous catheterization via peripheral vein WAN Li Objective To explore the nursing effect of continuous nursing service on patients with central venous catheter(PICC)implantation via peripheral vein.Methods All of 400 patients with PICC catheterization admitted from January 2017 to October 2018 were selected as the study subjects.They were divided into control group and research group according to random number table method,200 cases in each group.The control group was received routine nursing methods,while the research group was received continuing nursing service intervention.The incidence of catheter-related complications,unplanned extubation,nursing total satisfaction and WHOQOL-00 score before and after nursing were compared between the two groups.Results The total incidence of complications in the study group was 2.00%,lower than 10.50%in the control group,with statistical significance (P<0.05);the nursing satisfaction rate in the study group was 99.00%,higher than 91.50%in the control group,with statistical significance(P<0.05);there was no statistical difference in the physiological health score,psychological state score,independent ability score and social relationship score between the two groups before nursing(P＞0.05);the physical health score,psychological state score,independent ability score and social relationship score of the study group after nursing were higher than those of the control group,the differences were statistically significant(P＜0.05）.Conclusions Continuing nursing interventions for patients with PICC catheterization can significantly improve the quality of life of patients and reduce catheter-related complications Incidence and unplanned rate,improve nursing satisfaction,it has higher clinical application value. 2019 Vol. 26 (16): 241-243 [Abstract] ( 86 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 244 Effect of traditional Chinese medicine acupoint sticking on improving gastrointestinal function recovery and nursing satisfaction after gynecological laparoscopy WANG Qun-hui Objective To study the effect of the traditional Chinese medicine on the recovery of gastrointestinal function and the improvement of nursing satisfaction in the operation of gynecological laparoscopic operation.Methods From May 2017 to April 2018,90 cases of gynecologic laparoscopic surgery in our hospital were selected and divided into control group and observation group according to random number table method,45 cases in each group.The control group was given conventional nursing,the observation group was used traditional Chinese medicine acupoint sticker on the basis of conventional nursing.The incidence of postoperative abdominal distension,gastrointestinal function recovery and total nursing satisfaction were compared between the two groups.Results The first exhaust time,recovery time of bowel sound and defecation time were shorter in the observation group than those in the control group(P<0.05).The degree of postoperative abdominal distension in the observation group was significantly lighter than that in the control group (P<0.05),and the total nursing satisfaction in the observation group was 97.78%,which was higher than that in the control group (80.00%,P<0.05).Conclusion In the nursing of patients after gynecological laparoscopy,acupoint paste of traditional Chinese medicine can promote the recovery of gastrointestinal function,reduce the occurrence of abdominal distension,and improve the satisfaction of nursing. 2019 Vol. 26 (16): 244-246 [Abstract] ( 68 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 247 Effect of PDCA nursing mode on improving sleep quality of psychiatric patients LI Miao-yin Objective To discuss the effect of PDCA nursing mode on improving sleep quality of psychiatric patients.Methods A total of 76 patients admitted to department of psychiatry in our hospital from February 2017 and July 2018 were selected as the subjects,and randomly divided into observation group and control group,with 38 cases in each group.The control group was intervened by routine nursing methods.The observation group used PDCA.The Pittsburgh sleep quality index score and the self-rating sleep scale score of hospitalized patients were compared between the two groups.Results After the nursing intervention,the Pittsburgh sleep quality index score in the observation group were lower than those in the control group,and the sleep self-rating scale socre better than that in the control group,the differences were statistically significant(P<0.05).Conclusion After implementing PDCA nursing mode,patients′sleep quality has been significantly improved.It can be seen that PDCA nursing mode has a high clinical application value. 2019 Vol. 26 (16): 247-249 [Abstract] ( 87 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 250 Application effect of targeted nursing intervention in ICU patients with cerebral hemorrhage LI Jian; GONG Li-ping; CAO Ri-jin Objective To explore the application effect of targeted nursing intervention in ICU patients with cerebral hemorrhage.Methods Seventy patients with cerebral hemorrhage treated by ICU from May 2016 to April 2018 were selected as the study subjects.They were randomly divided into the control group(35 cases)and intervention group(35 cases)according to the random number method.The control group was given routine nursing intervention,while the intervention group was given targeted nursing intervention.The blood gas index levels before and after intervention and the incidence of complications during nursing were compared in patients between the two groups.Results The blood gas index levels of the two groups after intervention were significantly higher than those before intervention,with statistical differences(P<0.05).After nursing intervention,the blood gas index levels of the intervention group were significantly higher than those of the control group,with statistical differences (P<0.01).The rates of aspiration,pulmonary infection and hypoxemia in intervention group were 2.86%,0.00%and 0.00%,which were lower than those in control group(25.71%,11.43%and 11.43%,respectively),and the differences were statistically significant(P<0.05).The incidence of pressure ulcer after intervention in both groups was 2.86%,and there was no significant difference between the two groups(P>0.05).Conclusion Targeted nursing intervention can significantly reduce the incidence of aspiration,pulmonary infection and hypoxemia in ICU patients with cerebral hemorrhage,and improve the blood gas index of patients with satisfactory effect. 2019 Vol. 26 (16): 250-252 [Abstract] ( 61 ) HTML (29 KB)  PDF  (0 KB)  ( 8 )

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