低分子肝素辅助治疗复发性流产的临床效果及对免疫功能、激素水平的影响

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Abstract Objective To explore the clinical effects of Low Molecular Weight Heparin combined with traditional placenta therapy in the treatment of patients with recurrent spontaneous abortion and its influence on immune function and hormone levels.Methods A total of 204 patients with recurrent spontaneous abortion who admitted to our hospital from February 2016 to March 2017 were selected as the research objects.According to the random number table method,the patients were divided into the control group(102 cases)and the study group(102 cases).The control group was treated with traditional placenta therapy,while the study group was treated with Low Molecular Weight Heparin as adjuvant therapy on the basis of the control group.Pregnancy outcomes,the level of serum estradiol(E2),human chorionic gonadotropin(HCG),progesterone(P),interleukin-4(IL-4),interferon-γ (IFN-γ),IFN-gamma/IL-4 and adverse reactions were compared between the two groups.Results The success rate of fetal protection in the study group was 88.24%,which was higher than that in the control group(59.80%),and the difference was statistically significant(P＜0.05).The level of IFN-γ and IFN-γ/IL-4 in the study group after intervention were lower than those in the control group,and the difference was statistically significant(P＜0.05).The levels of IL-4,HCG,P,and E2in the study group after intervention were higher than those in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Recurrent abortion with traditional placenta therapy combined with Low Molecular Weight Heparin treatment can significantly improve the success rate of fetal protection,improve the body hormone level and immune function,and the incidence of adverse reactions is low.

Key words： Low Molecular Weight Heparin Recurrent abortion Immune function Hormone

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	Articles by authors
	LIN Zhi-jin
	YANG Xiu-zhen
	ZHANG Jiong-lan
	CHEN Jian-ying
	LIN Xiao-tao
	CHEN Liang-wan

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LIN Zhi-jin,YANG Xiu-zhen,ZHANG Jiong-lan, et al. Clinical effect of Low Molecular Weight Heparin in the treatment of recurrent spontaneous abortion and its influence on immune function and hormone levels[J]. 中国当代医药, 2019, 26(16): 145-147.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I16/145

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