氟西汀联合抗精神病药物治疗精神分裂症伴强迫症状的临床效果

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Abstract Objective To investigate the clinical effect of Fluoxetine combined with antipsychotics in the treatment of schizophrenia with obsessive-compulsive symptoms.Methods A total of 83 schizophrenia patients with obsessive-compulsive symptoms who were treated in our hospital from August 2016 to March 2018 were selected as subjects.All patients met the diagnostic criteria of schizophrenia in the International Classification of Diseases(10th edition)(ICD-10),and they were divided into the control group(n=41)and the study group(n=42)according to the random number table method.Patients in the control group were treated with antipsychotics,and patients in the study group were treated with Fluoxetine on the basis of the control group.The treatment effect,the scores of Yale-Brown obsessive compulsive scale(Y-BOCS)and positive and negative symptom scale (PANSS)were observed and analyzed between the two groups of patients before treatment and after 8 weeks of treatment.The treatment emergent symptom scale (TESS)was used to record the incidence of adverse reactions during treatment in both groups.Results The total effective rate of treatment in the study group was 90.48%,which was significantly higher than that in the control group (70.73%),and the difference was statistically significant(P<0.05).There were no significant differences in the scores of Y-BOCS and PANSS between the two groups before treatment(P>0.05).The scores of Y-BOCS and PANSS in the two groups after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.01).The scores of Y-BOCS and PANSS in the study group after treatment were significantly lower than those in the control group,and the differences were statistically significant(P<0.01).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Fluoxetine combined with antipsychotics can significantly improve the mental and obsessive-compulsive symptoms in patients with obsessive-compulsive schizophrenia,and it does not increase the adverse reaction,which has the clinical application value.

Key words： Obsessive-compulsive symptoms Antipsy chotics Fluoxetine Schizophrenia Efficacy

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	LIANG Qi-sheng
	DU Ying

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LIANG Qi-sheng,DU Ying. Clinical effect of Fluoxetine combined with antipsychotics in the treatment of schizophrenia with obsessive-compulsive symptoms[J]. 中国当代医药, 2019, 26(16): 59-61转64.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I16/59

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