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2021 Vol. 28, No. 26
Published: 2021-09-18
 
 
4 Inhibitory effect of the main active components of Brucea javanica and Silythistle on the metabolism of Phenytoin
CHEN Yue-yue； LIU Yong； CHEN Yin-nan； LI Wei
Objective To evaluate whether the main components of Brucea and Milk thistle will inhibit Phenytoin metabolism in human liver microsomes.Methods Ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)was used to determine the formation rate of 5-(4-hydroxyphenyl)-5-phenylacetonitroide(P-HPPH),a metabolite of phenytoin,in ESI positive mode.The alteration of p-HPPH formation rate was employed to evaluate the inhibitory effect of brusatol,bruceine D,silybin A and silybin B on Phenytoin metabolism by human liver microsomes.Results Silybin A potently inhibited human liver microsomes catalyzed phenytoin metabolism with an IC50 values of 7.67 μmol/L.Silybin B was a moderate inhibitor with an IC50 values of 15.49 μmol/L.Brusatol and bruceine D showed no significant inhibitory effect.Conclusion In order to avoid drug interaction caused by adverse clinical response,the combination of silybin A and silybin B with antiepileptic drug phenytoin should be avoided.
2021 Vol. 28 (26): 4-7转13 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
8 Study on quality standard of Sanghuang of North Korea medicine
WANG Hui； WANG Yue-qi；YANG Shu-dong； HAN Da； SONG Ai-qun
Objective To establish the quality standard for Sanghuang of North Korea medicine.Methods Microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS)was used to determine the content of 26 elements in Sanghuang,thin layer chromatography(TLC)was used to identify Sanghuang,the content of Sanghuang′s polysaccharide and total flavonoids were determined by ultraviolet-visible spectrophotometry.Results The r value of standard curve,recovery rate and relative standard deviation(n=6)of 26 elements by ICP-MS met the requirements of Pharmacopoeia of the People′s Republic of China(2020,Volume Ⅳ).The five high content beneficial elements in 10 batches of Sanghuang from different areas were kalium(2772.0-6514.7 mg/kg),magnesium(1299.9-1938.2 mg/kg),calcium(523.62-1753.90 mg/kg),sodium(19.886-359.370 mg/kg)and iron(38.469-534.440 mg/kg).The TLC method was effective in the identification of Sanghuang.There were a good linear relationship of Sanghuang′s polysaccharide in the range of 0.024-0.120 mg(r=0.9982)and the total flavonoids of total flavonoids in the range of 0.2-1.2 mg(r=0.9996).Conclusion According to the Pharmacopoeia of the People′s Republic of China(2020,Volume Ⅰ),the content of five heavy metals and harmful elements in 10 batches of Sanghuang from different places do meet regulations;five high content beneficial elements may be related to the efficacy of Sanghuang;the other 16 low content elements have no safety risk so far.Ten batches of samples from different places are investigated.The established standard can effectively control the quality,which is of great significance to its research and development.
2021 Vol. 28 (26): 8-13 [Abstract] ( 51 ) HTML (50 KB)  PDF  (0 KB)  ( 8 )
14 Association analysis of BMI-1 and MMP-3 gene polymorphisms with breast cancer susceptibility in Han nationality
ZHANG Ming-long；WANG Xiu-hua；LYU Ying； LI Peng-hui；LIU Dan；MEI Qing-bu； LIU Wan-quan；ZHENG Li-hong
Objective To study the association between three single nucleotide polymorphisms of B-cell-specific moloney leukemia virus insection site 1(BMI-1)and matrix metalloproteinase 3(MMP-3)genes and breast cancer susceptibility in Han nationality.Methods Using the case-control study method,from January 2014 to July 2018,a total of 524 Han women with breast cancer treated in the Second Affiliated Hospital of Qiqihar Medical College,the Third Affiliated Hospital of Qiqihar Medical College,Qiqihar Jianhua Hospital,and Daqing Oilfield General Hospital were selected as the case group,and 518 healthy people receiving healthy checkup in the same period were selected as the control group.PCR-LDR technology was used to detect and type the genetic polymorphisms of BMI-1 gene rs1042059,rs201024480 locus and MMP-3 gene rs3025058 locus,and the risk value(OR)and 95% confidence interval(CI)were used to express the risk of breast cancer.Results There were statistically significant differences in allele frequency and genotype distribution of MMP-3 gene rs3025058 locus between the case group and the control group(P=0.008).There was no statistically significant difference in gene polymorphism of BMI-1 gene rs1042059 locus and rs201024480 locus between the case group and the control group(P>0.05).After adjusting for confounding factors,the risk of breast cancer in the population carrying allele 5A and genotype 5A5A was increased by 1.51 and 1.48 times respectively(OR=1.51,95%CI: 1.17-1.94; P=0.001 and OR=1.48,95%CI: 1.16-1.91; P=0.001).Conclusion The polymorphism of MMP-3 gene rs3025058 is associated with the risk of breast cancer,and can be used as a candidate locus for breast cancer
susceptibility genes.
2021 Vol. 28 (26): 14-17 [Abstract] ( 50 ) HTML (40 KB)  PDF  (0 KB)  ( 6 )
18 Comparison of effect of Dexmedetomidine and Sufentanil in preventing adverse reactions of Carboprost Tromethamine during cesarean section
XIANG Bo； LU Li-xiong； YU Jin
Objective To compare the effect of Dexmedetomidine and Sufentanil in preventing adverse reactions of Carboprost Tromethamine during cesarean section.Methods A total of 90 primiparas undergoing elective cesarean section under combined spinal epidural anesthesia in Chongqing Health Center for Women and Children from January to June 2020 were selected as the research objects,and they were divided into the Dexmedetomidine group(group D),the Sufentanil group(group S)and the normal saline group(group C)according to the random number table method,with 30 cases in each group.All the three groups were injected with Carboprost Tromethamine in the uterine body during the operation.At the same time,group D was given Dexmedetomidine intravenously,group S was given Sufentanil intravenously,and group C was given normal saline intravenously.The amount of intraoperative rehydration,intraoperative blood loss,urine volume and adverse reactions were recorded.The mean blood pressure(MAP),heart rate(HR),respiration rate(RR)and pulse oxygen saturation(SpO2)were compared with each other in Rest for 10 min(baseline),immediately after intramuscular injection(T0),2 min after injection(T2),5 min after injection(T5),10 min after injection(T10)and at the end of operation between the three groups,and the Ramsay sedation score were observed.Results There was no statistical significance in intraoperative fluid rehydration,intraoperative blood loss and urine volume among the three groups(P＞0.05).The MAP at T2,T5,T10 and end of group D was lower than that of group C,and the MAP at T10 and end of group D was lower than that of group S,the differences were statistically significant(P＜0.05).The HR of group D at T2,T5,T10 and end was lower than that of group C and group S,the differences were statistically significant(P＜0.05).The RR of group D was lower than that of group S and group C at the end,the differences were statistically significant(P＜0.05).There was no significant difference in SpO2 levels among the three groups at each time point(P＞0.05).The intraoperative Ramsay sedation score of group D and S was better than that of group C,the differences were statistically significant(P＜0.05).The incidence of nausea,vomiting and chills in group D and S was lower than that in group C,the differences were statistically significant(P＜0.017).Conclusion In cesarean section,intrauterine injection of Carboprost Tromethamine combined with Dexmedetomidine or Sufentanil can play a sedative effect,effectively reduce the incidence of headache,nausea,vomiting and shivering,but Dexmedetomidine can inhibit the increase of blood pressure and heart rate,and the hemodynamics is more stable.
2021 Vol. 28 (26): 18-22转35 [Abstract] ( 53 ) HTML (54 KB)  PDF  (0 KB)  ( 7 )
23 Study of the effects and mechanisms of gastrodin on acute hyperuricemia of mice induced by hypoxanthine
CHU Ya-hui ；KONG Wei-jia
Objective To study the effects and possible mechanisms of gastrodin(GAS)on acute hyperuricemia(HUA)of mice induced by hypoxanthine.Methods A total of 50 male Kunming mice were randomly divided into five groups,which included the normal group,the model group,GAS 200 mg/kg group,GAS 400 mg/kg group,and allopurinol(ALLO)10 mg/kg group.There were 10 mice in each group,and the drugs were intragastricaly administered for 14 days.One hour after the last drug administration,mice were intraperitoneally injected with hypoxanthine at a dose of 1000 mg/kg,except for the normal group.Blood samples were collected for the assay of serum biochemical parameters 45 minutes after the injection.The animals were then sacrificed,and their livers were harvested for the determination of xanthine oxidase(XOD)activity by a kit.The kidneys were also collected for RNA extraction,and after reverse transcription,the mRNA expression levels of urate transporter 1(URAT1)and organic anion transporter 1(OAT1)were determined by quantitative real-time PCR.Results The serum uric acid(UA)level and liver XOD activity of the model group were higher than that of the normal group,the mRNA expression level of URAT1 in the kidney was higher than that of the normal group,while the mRNA expression level of OAT1 was lower than that of the normal group,the differences were statistically significant(P＜0.01 or P＜0.001).Administration of 200 mg/kg and 400 mg/kg of GAS decreased serum UA of the mice.Meanwhile,they also reduced liver XOD activity,decreased renal URAT1 mRNA expression level and increased that of OAT1(P＜0.05 or P＜0.01 compared to model group).ALLO restored the above parameters to normal(P＜0.01 or P＜0.001 compared to model group).Conclusion GAS improves acute HUA of mice induced by hypoxanthine,which may be attributable to inhibition of liver XOD activity,down-regulation of renal URAT1 mRNA expression,and up-regulation of renal OAT1 mRNA expression.
2021 Vol. 28 (26): 23-26 [Abstract] ( 74 ) HTML (40 KB)  PDF  (0 KB)  ( 8 )
27 Application of early low calorie nutritional support on mild hyperlipidemic acute pancreatitis
TU Yun-fan； LIN Pei-wen
Objective To study the application of early low calorie nutritional support on mild hyperlipidemic acute pancreatitis(HLAP)patients.Methods A total of 46 patients with mild HLAP in the First Affiliated Hospital of Xiamen University from March to November 2020 were selected as the rasearch objects and divided into the standard calorie group and the low calorie group by random number table method,with 23 cases in each group.In early disease stage,the standard calorie group patients were supplied with a nutritional support of 24 kcal/kg per day,while the low calorie group patients were supplied with a nutritional support of 11 kcal/kg per day.After 3 days of different nutritional support,the therapeutic effect(including triglyceride[TG],amylase[AMY],lipase[LIP],C-reaction protein[CRP],interleukin-6[IL-6]and procalcitonin[PCT]),gastrointestinal function recover time(including the remission time of abdominal pain and distension,first exhausting/defecating time and the time of intestinal peristaltic sound resuming to 5 times/minute),incidence of hypoglycemia(blood glucose＜2.8 mmol/L)and prognosis(including severity progress,fatality rate and hospital stay length)were compared.Results After 3 days of treatment,TG,CRP and IL-6 in low calorie group were lower than those in standard calorie group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in AMY,LIP and PCT between the two groups after 3 days of treatment(P ＞0.05).There were no statistically significant differences in the relief time of abdominal pain and distension,the time for the first exhaust or defecation and the time for the recovery of bowel sounds to 5 times/min between the two groups(P＞0.05).No hypoglycemia occurred in the two groups.There was no statistically significant difference in the incidence of disease progression to moderate severe acute pancreatitis(MSAP)between the two groups(P＞0.05).No patients in the two groups progressed to severe acute pancreatitis(SAP)or died.The length of hospital stay in the low calorie group was shorter than that in the standard calorie group,and the difference was statistically significant(P＜0.05).Conclusion For mild HLAP patients,early low calorie nutritional support could promote serum lipid reduction,improve inflammation condition,shorten the hospital stay length,and will not affect the recovery of gastrointestinal function or increase the incidence of hypoglycemia,which provide a reference for clinicians to choose a better nutritional support for mild HLAP patients.
2021 Vol. 28 (26): 27-30 [Abstract] ( 51 ) HTML (37 KB)  PDF  (0 KB)  ( 5 )
31 Application progress of data mining technology in adverse drug reaction monitoring
GAO Song；GAO Yue-juan； ZHU Ren-ying；WANG Li-li；XIU Yan-li；BI Lin-yu
Data mining technology has been widely used in the monitoring of adverse drug reactions in the era of big data.The monitoring of adverse drug reactions has a long history.Combined with data mining technology to carry out more accurate and effective monitoring has become a hot issue today.There are many methods of adverse drug reaction monitoring,including frequency method,Bayesian method,association rule,cluster analysis,decision tree,principal component analysis,and active monitoring methods developed in recent years.In this paper,the application status and progress of the above methods in adverse drug reaction monitoring will be summarized in order to provide meaningful guidance for adverse drug reaction monitoring.
2021 Vol. 28 (26): 31-35 [Abstract] ( 47 ) HTML (42 KB)  PDF  (0 KB)  ( 9 )
36 Treatment status of triple negative breast cancer with integrated traditional Chinese and Western medicine
SUN Xiao-hu； FU Jun-ru； TANG Jing-jing
Different from other types of breast cancer,triple negative breast cancer(TNBC)is characterized by rapid growth,high degree of malignancy,poor pathological grade,early recurrence,poor prognosis and high mortality.Therefore,optimizing treatment measures and exploring effective therapies have become the focus of current breast cancer research and attention.The author believes that TNBC should be treated by stages,stages and the whole process of integrated Traditional Chinese and Western medicine.In this paper,the present situation and research progress of TNBC integrated Traditional Chinese and Western medicine were summarized.It is expected that with the in-depth study of TNBC and the full cooperation of Traditional Chinese and Western medicine,the diagnosis and treatment of TNBC can enter a more effective and accurate era.
2021 Vol. 28 (26): 36-41 [Abstract] ( 50 ) HTML (56 KB)  PDF  (0 KB)  ( 8 )
42 Research progress on the effect of vasoactive drugs on uterine circulation
YIN Yi-bo ；GUO Wen-jun
Uterine circulation is the core of nutrient and oxygen exchange between parturient and fetus.Factors affecting uterine circulation include hemodynamics,fluid management,use of vasoactive drugs,maternal posture and mode of anesthesia.However,there is no accurate definition of uterine circulation.Vasoactive drugs are one of the important influencing factors.Studies have shown that uterine circulation is related to the long-term outcome of the fetus.This article reviews the effects of vasoactive drugs on uterine circulation in order to guide the clinic and improve the long-term outcome of parturient and fetus.
2021 Vol. 28 (26): 42-45 [Abstract] ( 52 ) HTML (38 KB)  PDF  (0 KB)  ( 9 )
46 Research progress of erythropoietin and its derivatives on neuroprotection
HU Ming-pei；WANG Dan-dan；XU Ming-bo； YANG Zhong-fan；CAO Rong-yue
Erythropoietin(EPO)exerts an erythropoiesis effect by binding to the homodimer(EPOR)2 of the erythropoietin receptor(EPOR)and was initially used as an anemia treatment.In the past two decades,a large number of studies have confirmed that EPO can protect a variety of tissue systems,especially the nervous system,by anti-apoptosis,reducing inflammatory responses and supporting the reconstruction of damaged function by stimulating cell proliferation and differentiation.Further studies showed that the protective effect was mediated by EPOR/βCR,a heterodimer composed of EPOR and common β chain receptor(βCR).To avoid the side effects of erythropoiesis produced in the process of EPO treatment for tissue damage,different forms of EPO derivatives have been developed.This article aims to review the protective effects and mechanisms of EPO and its derivatives in the nervous system,hoping to provide guidance for the clinical application of EPO in neurological diseases.
2021 Vol. 28 (26): 46-50 [Abstract] ( 46 ) HTML (48 KB)  PDF  (0 KB)  ( 8 )
51 Research progress of microecological agents regulating intestinal microorganism of obesity
LU Lin-li；JU Hai-bing
Obesity has become a global epidemic disease that urgently needs to be solved.Studies have shown that obesity is related to the imbalance of intestinal microbiota in the body.The imbalance of intestinal microbiota leads to the disorder of substance and energy metabolism,metabolic endotoxemia,systemic inflammation and insulin resistance in the obese body.Prebiotics can be fermented by intestinal probiotics to produce short-chain fatty acids and other metabolites to improve the diversity and abundance of the intestinal microbiota of the obese body,increase energy consumption,and reduce fat deposition.Meanwhile,short-chain fatty acids can stimulate gastrointestinal hormones of satiety,reduce inflammation,improve insulin resistance,and reduce appetite through the microbiota-gut-brain axis.Prebiotics,probiotics and their derived microecological agents(probiotics,probiotics,synbiotics,postbiotics)have become the hot spot and new strategy for the beneficial treatment of obesity.This research reviews the effect of microbiological products in the treatment of obesity,discusses the related mechanisms,and makes a prospect for its treatment in the future.
2021 Vol. 28 (26): 51-55 [Abstract] ( 51 ) HTML (47 KB)  PDF  (0 KB)  ( 10 )
56 Research on application of virtual 3D surgical simulation in unicompartmental kenn arthroplasty
DENG Gang； CAI Xing-jian； WU Ai-ping ；XIAO Shi-liang
Objective To explore the application value of virtual 3D surgical simulation in unicompartmental kenn arthroplasty(UKA).Methods Thirty patients with osteoarthritis(OA)of medial compartment of knee joint who were admitted to Ganzhou People′s Hospital from January 2019 to December 2020 for UKA were selected and divided into study group(15 cases)and control group(15 cases)according to random number table method.The study group was given virtual 3D surgical simulation assisted UKA,while the control group was given conventional UKA.Operation-related indexes,postoperative imaging indexes and joint function recovery were compared between the two groups.Results The intraoperative blood loss and postoperative drainage volume in the study group were less than those in the control group,the duration of operation and postoperative hospital stay in the study group were shorter than those in the control group,the height of knee joint extension space and the angle of knee varus in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).The Tegner knee motion scores and Lysholm knee joint scores in both groups after surgery were higher than those before surgery,and the differences were statistically significant(P＜0.05).The postoperative Tegner knee joint motion scores and Lysholm knee joint scores were not significantly different between the two groups(P＞0.05).Conclusion Virtual 3D surgical simulation assisted UKA can reduce surgical trauma,reduce intraoperative blood loss and postoperative drainage volume,improve postoperative imaging indicators,and shorten postoperative recovery time,which is worthy of clinical promotion.
2021 Vol. 28 (26): 56-58转62 [Abstract] ( 50 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
59 Research on the application of intelligent body temperature detection system in the temperature management of fever patients
WANG Xiao-juan ；WANG Yan； XU Feng ；ZHAO Xue-jia
Objective To explore the effect of VIVALNK′s intelligent body temperature detection system in measuring the body temperature of fever patients,and to provide a basis for continuous intelligent body temperature monitoring.Methods A total of 65 patients with body temperature above 37.3℃admitted to the fever observation ward in Maternal and child health care hospital of Ningxia Hui Autonomous Region from March to June 2020 were selected as the research objects.The body temperature of patients was measured by mercury thermometer,VIVALNK intelligent body temperature paste and mercury thermometer.Taking mercury thermometer as the gold standard,the measurement results of VIVALNK intelligent body temperature paste and TP500 frontal thermometer and the cognition of patients(or family members of children)on the use of intelligent body temperature paste were compared.Results There was no significant difference between the average body temperature of VIVALNK smart body temperature patch and mercury thermometer(P>0.05);a total of 96.92% of patients(or family members of patients)could accept the use of smart body temperature patch in the hospital.Conclusion The effect of VIVALNK intelligent body temperature patch to monitor body temperature is highly consistent with that of mercury thermometers,and can continuously monitor body temperature changes for 24 hours,and is easy to be accepted by patients,and clinical use is feasible.
2021 Vol. 28 (26): 59-62 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
63 Application of improved cervical collar in "beach chair" position surgery
YANG Shu-qin； CHEN Mei； CAI Jie
Objective To explore the application value of improved cervical collar in "beach chair" position surgery.Methods A total of 86 patients with "beach chair" posture surgery in the First Affiliated Hospital of Gannan Medical College from January 2019 to December 2020 were selected as the research subjects.According to the random number table method,they were divided into the improved cervical collar group(43 cases)and the traditional fixation group(43 cases).The traditional fixation group was performed by the traditional fixation method,and the improved cervical collar group was performed by the improved cervical collar method.The fixation effect,comfort level,preoperative postural placement time,incidence of adverse events and patient satisfaction were compared between the two groups.Results The fixation stability rate of the improved cervical collar group was higher than that of the traditional fixation group,and the difference was statistically significant(P＜0.05).The surgical impact rate of the improved cervical collar group was lower than that of the traditional fixation group,the difference was statistically significant(P＜0.05).The head and neck comfort rate of the improved cervical collar group and the fixation comfort rate were higher than those of the traditional fixation group,the differences were statistically significant(P＜0.05).The preoperative positioning time of the improved cervical collar group was shorter than that of the traditional fixation group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse events between the two groups(P＞0.05).The total satisfaction of patients surgical in the improved cervical collar group was higher than that in the traditional fixation group,and the difference was statistically significant(P＜0.05).Conclusion The application of the improved cervical collar in the "beach chair" position surgery can shorten the preoperative position placement time,improve the fixation effect and comfort level,reduce the influence on the operation,avoid postoperative neck discomfort and other adverse events,and improve patient surgical satisfaction.
2021 Vol. 28 (26): 63-66 [Abstract] ( 52 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
67 Application value of gastrointestinal ultrasound in clinical practice
LI Ying；LUO Wen-ming；LIU You-yuan；CHEN Xiang-yue；CHEN Hu-jun；SONG Bing
Objective To explore the clinical value of gastro intestinal ultrasound contrast in gastro duodenal disease.Methods Sixty patients with gastro duodenal diseases admitted to Brain Hospital of Hunan Province from May 2018 to May 2020 were selected as the research objects.Gastrointestinal contrast-enhanced ultrasonography and barium meal examination of upper digestive tract were given.The sensitivity,accuracy and specificity of gastrointestinal contrastenhanced ultrasonography and barium meal examination of upper digestive tract were compared with gastroscopy.Results A total of 15 cases(25.00%)of 60 patients were diagnosed as malignant lesions after endoscopic pathological examination,including 2 cases of gastric malignant lymphoma and 13 cases of gastric cancer.A total of 17 cases of malignant gastro duodenal diseases were diagnosed by gastrointestinal contrast-enhanced ultrasonography,including 3 cases of gastric malignant lymphoma and 14 cases of gastric cancer.After upper gastrointestinal barium meal examination,a total of 25 cases were diagnosed as malignant lesions,including 7 cases of gastric malignant lymphoma and 18 cases of gastric cancer.The sensitivity,accuracy and specificity(93.33%,93.33%,93.33%)of gastrointestinal contrast-enhanced ultrasound were higher than those of upper gastrointestinal barium meal contrast(46.67%,56.67%,60.00%),and the differences were statistically significant(P＜0.05).Conclusion Gastrointestinal contrast-enhanced angiography has high clinical value in the diagnosis of gastro duodenal diseases.It is simple,convenient,non-invasive,safe,and reproducible.It is suitable for large-scale census of gastro intestinal diseases and is worthy of promotion in primary hospitals.
2021 Vol. 28 (26): 67-69 [Abstract] ( 48 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
70 Application effect of autologous blood recovery and transfusion in the treatment of ectopic pregnancy and splenic rupture
LU Jian-pu； LI Yan-yuan； ZHANG Jian-hui； WANG Chuan-zhen
Objective To explore the application effect of autologous blood recovery and transfusion in the treatment of ectopic pregnancy and splenic rupture.Methods A retrospective analysis of 50 patients with ectopic pregnancy and splenic rupture admitted to Shishi Hospital in Fujian Province from June 2017 to December 2019.According to the blood transfusion method,they were divided into 25 cases in the control group,25 cases in the treatment group,patients in the control group were infused with allogeneic bamked blood,and patients in treatment group were infused with autologous blood.For allogeneic banked blood,the treatment group used autologous blood to be recovered and transfused to compare the adverse effects of blood transfusion,blood routine before and after surgery,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)levels between the two groups.Results Comparison of blood routine indexes between two groups of patients,and the difference was not statistically significant(P＞0.05);the incidence of adverse reactions in the treatment group was lower than that in the control group,and the difference was statistically significant(P＜0.05);the preoperative ESR and CRP levels of the two groups were compared,and the differences were not statistically significant(P＞0.05);the postoperative ESR and CRP levels of the treatment group were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion The recovery and transfusion of autologous blood for patients with ectopic pregnancy and splenic rupture can reduce the probability of adverse reactions of allogeneic blood transfusion,improve postoperative ESR,CRP and other indicators,and the effect is relatively ideal.
2021 Vol. 28 (26): 70-72 [Abstract] ( 55 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
73 Study on the effect of Pioglitazone Hydrochloride on vascular endothelial function in patients with type 2 diabetes
YU Jian-xin ；ZHOU Li-lan； XU Ren-wei
Objective To explore the effect of Pioglitazone Hydrochloride on vascular endothelial function in patients with type 2 diabetes.Methods A total of 80 patients diagnosed with type 2 diabetes in the Department of Endocrinology,Affiliated Hospital of Jiujiang University from January to December 2019 were selected as the research objects,and divided into the Pioglitazone group and the placebo group according to the random number table method,with 40 cases in each group.The placebo group received placebo treatment,and the Pioglitazone group received Pioglitazone Hydrochloride treatment.The blood glucose control effect,vascular endothelial function,and the asymmetric dimethylarginine(ADMA)and dimethylarginine-dimethylarginine in the peripheral serum,the level of methylamine hydrolase(DDAH),mental state scores,body mass index,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of endothelin(ET-1)and ADMA in the Pioglitazone group were lower than those in the placebo group,the differences were statistically significant(P＜0.05);nitric oxide(NO),blood flow-mediated vasodilation(Flow-mediated dilation,FMD)and DDAH levels in the Pioglitazone group after treatment were higher than those the placebo group,the differences were statistically significant(P＜0.05).After treatment,the fasting blood glucose content,two hours postprandial blood glucose content,glycosylated hemoglobin content,mental state scores,and body mass index of the Pioglitazone group were lower than those of the placebo group,the differences were statistically significant(P＜0.05).Conclusion Pioglitazone Hydrochloride is effective in the treatment of type 2 diabetes with good safety.More popularization and application can help improve the treatment effect and reduce the occurrence of adverse reactions.
2021 Vol. 28 (26): 73-76 [Abstract] ( 46 ) HTML (39 KB)  PDF  (0 KB)  ( 6 )
77 Application of high-frequency color Doppler ultrasound in surgical treatment of secondary hyperparathyroidism
XIONG Jian-ding； RAO Xun-jian；XIE Hai-tao； CHEN Yi-biao； LAI Ming-liang
Objective To investigate the application effect of high-frequency color Doppler ultrasound in surgical treatment of secondary hyperparathyroidism(SHPT).Methods A total of 40 patients with SHPT admitted to Fengcheng People′s Hospital from December 2018 to June 2020 were selected as the research objects.All patients were given highfrequency color ultrasound examination,parathyroidectomy and postoperative pathological diagnosis.The operative pathological results,ultrasonographic results and their accuracy,sensitivity and specificity were observed.The serum intact parathyroid hormone（iPTH）,calcium(Ca)and phosphorus(P)were compared between preoperative and postoperative.Results A total of 133 nodules were resected in 40 patients,and 118 parathyroid hyperplasia,eight lymph nodes,three thyroid nodules,two ectopic thymus glands,and two adipose tissue were pathologically diagnosed.The results of ultrasonography showed 103 enlargement or hyperplasia of parathyroid glands.The pathological diagnosis was considered as the golden standard.The accuracy,sensitivity and specificity of ultrasonic diagnosis were 78.20%,81.36% and 53.33%.The serum iPTH,Ca and P of 40 patients after operation were lower than those before operation,the differences were statistically significant(P＜0.05).Conclusion The application of high-frequency color Doppler ultrasound in the preoperative examination of SHPT has high accuracy and sensitivity,which provides an important reference basis for clinical treatment and preoperative positioning.
2021 Vol. 28 (26): 77-79转83 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
80 Influence of fire dragon cupping on pain and lumbar function in patients with lumbar disc herniation of cold-damp type
GUO Ya-li；LI Hai-ting； WANG Qing
Objective To explore the influence of fire dragon cupping on pian and lumbar function in patients with lumbar disc herniation(LDH)of cold-damp type.Methods A total of 68 patients with LDH of cold-damp type,who were admitted to Luoyang Orthopedic-Traumatological Hospital of He′nan Province(He′nan Procincial Orthopedic Hospital)from September 2020 to January 2021 were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,34 cases in each group.The control group was given routine orthopedic conservative treatment and nursing,and the observation group was given fire dragon cupping on the basis of the control group.The clinical efficacy,visual analogue scale(VAS)score and Japanese orthopaedic association(JOA)scores of the two groups were compared.Results After intervention,the total effective rate of the observation group was 90.91%,which was higher than that of the control group of 71.88%,and the difference was statistically difference(P＜0.05).The VAS score of the two groups after intervention was lower than that before intervention,and the difference was statistically significant(P＜0.05).The VAS score after intervention in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The JOA score of the two groups after intervention was higher than that before intervention,and the difference was statistically significant(P＜0.05).The JOA score of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The intervention of fire dragon cupping therapy in patients with LDH of colddamp type has certain clinical effect,which can relieve pain and improve lumbar function.
2021 Vol. 28 (26): 80-83 [Abstract] ( 63 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
84 Clinical effect analysis of Bushen Zhuanggu Decoction on reducing recurrent fracture after vertebroplasty
WU Ting-sheng； TAO Zhi-qiang；FAN Shao-yong
Objective To study the application effect of Bushen Zhuanggu Decoction combined with vertebroplasty in patients with osteoporotic fractures.Methods A total of 120 cases of osteoporotic fracture patients treated in the Tenth Department of Orthopedics of Hongdu Hospital of Traditional Chinese Medicine of Nanchang City from May 2017 to May 2018 were selected as the study objects.All cases were divided into the treatment group and the control group according to random number table method,60 cases in each group.The control group was treated with percutaneous vertebroplasty,and the treatment group was treated with Bushen Zhuanggu Decoction on the basis of percutaneous vertebroplasty.The Cobb angle,bone mineral density,visual analogue scale(VAS),the height of the anterior vertebral body,the height of the middle vertebral body and the incidence of fractures at 3,6,12 and 24 months were compared between the two groups.Results The Cobb angle and bone mineral density in the treatment group were lower than those in the control group,and the VAS score in the treatment group was lower than that in the control group,the differences were statistically significant(P＜0.05).The height of anterior body and the height of the midline vertebral body in the treatment group after treatment were higher than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference between the two groups in the incidence of recurrent vertebral fractures at 3 months after surgery(P＞0.05).The incidence of fracture at 6,12 and 24 months after surgery in the treatment group was lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion Percutaneous vertebroplasty combined with traditional Chinese medicine can improve bone mineral density and Cobb angle of osteoporotic fracture patients,reduce the degree of pain,reduce the incidence of fracture after treatment,and the effect is safe and reliable.
2021 Vol. 28 (26): 84-87 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
88 Analysis of the effect of combined spinal internal fixation in the treatment of intraspinal tumors with the aid of microscope
CHEN Wen-ming ；KANG Jian； ZHANG Ting； HU Xin-yuan； WEN Jian； TONG Jian-ping； DENG Kun-kang
Objective To analyze the effect of microscope-assisted tumor resection combined with spinal internal fixation in the treatment of intraspinal tumors.Methods A total of 60 patients with intraspinal tumors in the Pingxiang People′s Hospital from January 2015 to May 2020 were selected as the research objects,and they were divided into the control group(30 cases)and the study group(30 cases)using a random number table method.The control group was treated with a microscope-assisted tumor resection,and the study group was treated with spinal internal fixation on the basis of the control group.The perioperative indicators,postoperative complications,and neurological function ratings before operation and 6 months after operation were compared between the two groups.Results There was no statistically significant difference in operation time,intraoperative blood loss and postoperative hospital stay between the two groups(P＞0.05).The total incidence of complications in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).At 6 months after operation,the neurological function ratings of the two groups were better than those before the operation,and the neurological function ratings of the study group was better than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Microscope-assisted tumor resection combined with spinal internal fixation can effectively reduce the neurological damage of patients with intraspinal tumors,reduce the incidence of complications,and have a positive impact on the patient′s postoperative recovery.
2021 Vol. 28 (26): 88-90 [Abstract] ( 48 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
91 Development of improved universal single pulley traction frame and its application in shoulder arthroscopic surgery
HUANG Cai-hong; LIU Jin-ming; GAO Yuan-yan; CHEN Min
Objective To explore the development of improved universal single pulley traction frame and its application in shoulder arthroscopic surgery.Methods A total of 88 patients who underwent arthroscopic surgery in the First Affiliated Hospital of Gannan Medical College from January 2019 to December 2020 were selected and divided into the control group(44 cases)and the observation group(44 cases)according to the random number table method.The control group was treated with the conventional beach chair position,and the observation group was treated with the improved universal single pulley traction frame to adopt the lateral lying traction position.The general comfort questionnaire(GCQ)scores before and six hours after operation and the patients′ satisfaction with the application of the traction frame of the two groups were compared.Results Six hours after operation,the GCQ score of the observation group was higher than that of the control group,and the total satisfaction degree of postural traction was higher than that of the control group,with statistical differences(P＜0.05).Conclusion The improved universal single pulley traction frame used in shoulder arthroscopic surgery can improve the patient′s comfort and satisfaction with the position traction.
2021 Vol. 28 (26): 91-93 [Abstract] ( 55 ) HTML (29 KB)  PDF  (0 KB)  ( 6 )
94 Repair of soft tissue defects of extremities with anterolateral thigh perforator flap and free skin graft combined with acuum assisted closure
YAO Bin； AO Zhi-ping ；TONG Xiao-hua； LI Bang-liang
Objective To analyze the effect of anterolateral thigh perforator flap combined with free skin graft combined with vacuum scaling drainage(VSD)in repairing soft tissue defects of extremities.Methods From April 2020 to January 2021,60 patients with soft tissue defects of limbs admitted to the First Affiliated Hospital of Jiangxi Medical College were selected as research objects,and they were randomly divided into control group(30 cases)and observation group(30 cases)according to the random number table method.The control group was treated with traditional flap repair and routine dressing change,while the observation group was treated with anterolateral thigh perforator flap combined with free skin grafting combined with VSD.The survival rate of skin flap transplantation,satisfaction of limb function recovery,postoperative complications and wound infection rate were compared between the two groups.Results The survival rate of skin flap transplantation and the satisfaction of limb function recovery in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The wound infection rate and total incidence of postoperative complication in the observation group were lower than those in the control group,with statistical differences(P＜0.05).Conclusion Anterolateral thigh perforator flap combined with free skin graft combined with VSD can improve the survival rate of flap transplantation,reduce the incidence of infection and postoperative complications in patients with soft tissue defects of the extremities,and patients are satisfied with the recovery of limb function.It is worthy of being widely popularized.
2021 Vol. 28 (26): 94-97 [Abstract] ( 49 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
98 Clinical study of intra-articular injection of Sodium Hyaluronate for joint function rehabilitation after tibial plateau fracture
LIN Yong-hang； CHEN Ding-qi ；WANG Sheng-lang； TAN Qing-hao； ZHENG Kai-da； FENG Shi-hua ；YE Zhi-hui
Objective To explore the influence of intra-articular injection of Sodium Hyaluronate on joint function rehabilitation after tibial plateau fracture.Methods A total of 80 inpatient postoperative patients with tibial plateau fractures who were admitted to the First Department of Orthopedics of Yangjiang Traditional Chinese Medicine Hospital from August 2019 to November 2020 were selected,and they were divided into the control group(40 cases)and the observation group(40 cases)by lottery methods.The control group was given guidance and standardized knee joint functional exercises after operation,and the observation group was given intra-knee injection of Sodium Hyaluronate injection on the basis of the control group after 2 weeks after operation.Both groups were intervened for 4 weeks.After 6 weeks,the knee joint recovery of the two groups were recorded,and the pain scores of functional exercise at 2,4,and 6 weeks after operation and the occurrence of postoperative complications were compared between the two groups.Results The scores of pain,symptoms,activities of daily living,exercise and recreational ability,knee joint-related quality of life,and the excellent and good rate of the observation group were higher than those of the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the functional exercise VAS scores between the two groups at 2 weeks after operation(P＞0.05).The functional exercise VAS scores in the observation group at 4 and 6 weeks after operation were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Intra-articular injection of Sodium Hyaluronate after tibial plateau fracture can effectively improving the knee joint function of patients,reducing the pain score of functional exercise,and reducing the incidence of postoperative complications.
2021 Vol. 28 (26): 98-100 [Abstract] ( 52 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
101 Clinical study of external fixator combined with vacuum sealing drainage and skin flap transplantation in the treatment of open tibiofibular fracture with soft tissue defect
WEI Shi-qiang；WANG An-hong；XI Chen
Objective To explore the effect of external fixator combined with vacuum sealing drainage(VSD)and skin flap transplantation in the treatment of patients of open tibiofibular fracture with soft tissue defect.Methods A total of 80 patients with open tibiofibular fracture and tissue defect admitted to the Ganzhou People′s Hospital from July 2020 to February 2021 were selected as the research objects.According to the random number table method,they were divided into the control group(40 cases)and the observation group(40 cases).The control group was treated with external fixator combined with conventional dressing change,the second stage was treated with flap transplantation.The observation group was treated with external fixator combined with VSD.The treatment effect,clinical related indicators(wound cleaning time,fracture healing time,granulation tissue time,hospitalization time),ankle joint and quality of life scores were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The wound cleaning time,fracture healing time,granulation tissue appearance time,hospitalization time of the observation group were shorter than those of the control group,the differences were statistically significant(P＜0.05).The ankle score and quality of life score of the observation group were higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion The application of external fixator combined with VSD and skin flap transplantation in the treatment of open tibiofibular fracture and soft tissue defect is effective.
2021 Vol. 28 (26): 101-104 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
105 Clinical research of operation combined with infrared radiation,wax therapy and Baduanjin functional exercise in the treatment of lumbar disc herniation
WEI Zi-you； ZHU Ning；LIU Wu-yang
Objective To explore the clinical effect of surgery combined with infrared radiation,wax therapy,and Ba Duan Jin functional exercise in the treatment of lumbar disc herniation.Methods From January to February 2020,101 patients with lumbar intervertebral disc herniation in the Orthopedics Department of the Third Affiliated Hospital of Gannan Medical College were selected as the research objects.They were divided into the reference group(50 cases)and the treatment group(51 cases)according to the random number table.The reference group was treated with small incision fenestration nucleus pulposus,and the treatment group was combined with infrared radiation,wax therapy,and Baduanjin functional exercise therapy on the basis of the reference group.The degree of pain,lumbar spine function and efficacy before and after treatment were compared between the two groups.Results There were no significant difference in visual analogue scale(VAS)score and Japanese orthopaedic associations(JOA)score between the two groups before treatment(P＞0.05).After treatment,the VAS score of the treatment group was lower than the reference group,and the JOA score was higher than the reference group ,the differences were statistically significant(P＜0.05).The total effective rate of treatment in the treatment group was higher than that of the reference group,and the difference was statistically significant(P＜0.05).Conclusion Surgery combined with infrared radiation,wax therapy,and Ba Duan Jin functional exercise to treat lumbar intervertebral disc herniation can better relieve the patient′s pain and improve the lumbar function.The effect is significant,and it can be preferred.
2021 Vol. 28 (26): 105-107转111 [Abstract] ( 54 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
108 Effect of different administration times of Tranexamic Acid on blood loss during and after the initial unilateral total hip arthroplasty
LIAO Zhang-yu； LIU Hong-yan； ZENG Xian-hui
Objective To investigate the effect of different administration times of Tranexamic Acid on blood loss during and after the initial unilateral total hip arthroplasty.Methods A retrospective analysis was performed on the clinical data of 75 patients who underwent primary unilateral total hip replacement in the Second Department of Orthopedics,Nankang District Traditional Chinese Medicine Hospital from December 2018 to February 2021.According to the time of medication,they were divided into control group,preoperative group and intraoperative group with 25 cases each.All three groups were treated with routine infection prevention,anticoagulation and fluid rehydration after operation.The control group was not given hemostatic drugs.The preoperative group was given 1 g Tranexamic Acid intravenously 10 min before surgery,and 1 g intravenous drip again 6 h after surgery.The intraoperative group was given 1 g Tranexamic Acid intravenous infusion 10 min before the end of surgery,and another 1 g tranexamic acid intravenous infusion 6 h after surgery.Intraoperative blood loss,postoperative drainage,recessive blood loss,total blood loss and the number of cases of blood transfusion,hemoglobin levels 24 h before surgery,12 h,24 h and 36 h after surgery were compared among the three groups.Seven days after the operation,the blood vessels of the affected limb were reexamined by color doppler ultrasonography.Results The intraoperative blood loss,postoperative drainage,hidden blood loss and total blood loss in the preoperative and intraoperative groups were lower than those in the control group,the differences were statistically significant(P＜0.05),and the preoperative group had less intraoperative blood loss and postoperative drainage than the intraoperative group,the differences were statistically significant(P＜0.05).24 h before operation,there was no significant difference in hemoglobin level among the three groups(P ＞0.05).The hemoglobin of preoperative group and intraoperative group was higher than that of control group 12,24,36 h after operation,and the differences were statistically significant(P＜0.05).One patient in the preoperative group and one patient in the intraoperative group received blood transfusion,and the rate of blood transfusion was 4.00%(1/25),lower than that of the control group(24.00%,6/25),the differences were statistically significant(P＜0.05).No lower limb venous thrombosis occurred in the three groups.Conclusion Preoperative and intraoperative application of Tranexamic Acid can reduce blood loss after initial unilateral total hip replacement,reduce blood transfusion rate,and do not increase the risk of thrombosis,and the effect of preoperative administration is slightly better than that of intraoperative administration.medicine.
2021 Vol. 28 (26): 108-111 [Abstract] ( 54 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
112 Clinical effect of Wiltse approach decompression and fixation fusion in the treatment of lumbar disc herniation
ZHENG Hao-fen； ZHENG Hao-xia ；LI Guan-zhen； SU Jian； MA Gui-chu
Objective To investigate the clinical effect of Wiltse approach decompression and fixation fusion in the treatment of lumbar disc herniation.Methods The clinical data of 80 patients with lumbar disc herniation treated in the Department of Orthopedics of Qinzhou Hospital of Traditional Chinese Medicine from July 2018 to July 2020 were analyzed retrospectively.According to the surgical method,they were divided into the control group(40 cases)and the intervention group(40 cases).Tthe control group used the posterior median approach for fusion,and the intervention group used the Wiltse approach for fusion.The operation time,intraoperative blood loss,postoperative drainage,postoperative pain,and recovery were compared between the two groups.Results The operation time of the intervention group was shorter than that of the control group,and the difference was statistically significant(P＜0.05).The intraoperative blood loss and postoperative drainage volume of the intervention group were less than those of the control group,the differences were statistically significant(P＜0.05).The scores of visual analogue scale(VAS)in the intervention group at 3 and 14 days after operation were lower than those in the control group,and the differences were statistically significant(P＜0.05).The Oswestry dysfunction index(ODI)of the intervention group at 1 and 6 months after operation were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion The Wiltse approach is more effective than the posterior median approach in the treatment of lumbar disc herniation,which can improve the surgical index,quickly relieve the postoperative pain of the patient,and promote the postoperative recovery.It is worthy of popularization and application.
2021 Vol. 28 (26): 112-114转119 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
115 Effect of minimally invasive pedicle screw fixation on Cobb′s angle and anterior vertebral height in patients with traumatic thoracolumbar spinal fractures
LI Rong-jun；ZHANG Meng
Objective To investigate the effect of minimally invasive pedicle screw fixation(MIPSF)on Cobb′s angle and anterior vertebral height(AVH)in patients with traumatic thoracolumbar spinal fractures(TTSF).Methods A total of 80 patients with TTSF treated in Dalian Second People′s Hospital from August 2017 to December 2019 were selected,the patients were divided into the control and the study group according to different surgical procedures,40 cases in each group.Patients in the control group were treated with traditional open pedicle screw fixation,while patients in the study group were treated with MIPSF.Cobb′s angle,AVH,clinical indicators,visual analogue scale(VAS)score,lumbar function and postoperative complications were compared between the two groups.Results There were no significant differences in the Cobb′s angle or AVH between the two groups before surgery(P＞0.05).At 6 months after surgery,the Cobb′s angle of the two groups were less than before surgery,AVH of the two groups were greater than before surgery,the differences were statistically significant(P＜0.05);but there were no significant differences between the two groups(P＞0.05).The operative time and hospital stay of the study group were shorter than those of the control group,the length of surgical incision of the study group was shorter than that of the control group,the amount of blood loss and the volume of drainage in the study group were less than that in the control group,the differences were statistically significant(P＜0.05).There were no significant differences in VAS score and Japanese Orthopedic Association(JOA)score of lumbar function between the two groups before surgery(P＞0.05).At one week and two months after surgery,and the VAS score were lower than before surgery,lumbar spine function JOA score were higher than before surgery,VAS score in the study group was lower than that in the control group,and JOA score in the study group was higher than that in the control group,the differences were statistically significant(P＜0.05).The total incidence of surgical incision infection,internal fixation displacement,bone nonunion and vascular and nerve injury in the study group was 7.5%,lower than that of the control group accounting for 32.5%,the difference was statistically significant(P＜0.05).Conclusion MIPSF for TTSF can effectively improve the reducing Cobb′s angle and AVH,improve the clinical indicators,promote the functional recovery of the lumbar spine and reduce postoperative complications,and is worthy of clinical promotion and application.
2021 Vol. 28 (26): 115-119 [Abstract] ( 46 ) HTML (40 KB)  PDF  (0 KB)  ( 7 )
120 Short-term clinical efficacy of 4K ultra hd laparoscopy in the treatment of rectal cancer
ZHUANG Hai-wen； WANG Jian ；ZHAO Hai-jian； ZHANG Xiao-yu
Objective To investigate the short-term clinical effect of 4K ultra high definition laparoscopy in the treatment of rectal cancer.Methods Clinical data of 60 patients who underwent laparoscopic radical resection of rectal cancer in Huai′an Second People′s Hospital from January 2018 to October 2020 were retrospectively analyzed.According to different laparoscopic systems used in surgery,the patients were divided into 4K group and 2D group,with 30 patients in each group.The 4K group was operated with German Xion 4K Ultra High Definition laparoscopic system,while the 2D group was operated with German Storz High Definition laparoscopic system.The operative time,intraoperative blood loss,number of lymph nodes,postoperative exhaust time,postoperative first time out of bed and postoperative complications were compared between the two groups.Results All 60 patients successfully completed laparoscopic surgery.The operation time of 4K group was shorter than that of 2D group,the intraoperative blood loss of 4K group was less than that of 2D group,and the differences were statistically significant(P＜0.05).There were no significant differences in the number of lymph nodes acquired,postoperative exhaust time,postoperative first time out of bed and incidence of postoperative complications between two groups(P＞0.05).Conclusion The 4K ultra high definition laparoscopic system has the same safety and effectiveness as the 2D high-definition laparoscopic system.The short-term outcome is efficient.Compared with the 2D high definition laparoscopic system,the 4K ultra high-definition laparoscopic system can reduce the operative time and intraoperative blood loss in laparoscopic rectal cancer surgery.
2021 Vol. 28 (26): 120-122转129 [Abstract] ( 48 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
123 Application of Compound Kushen Injection in the treatment of rectal cancer patients with radiotherapy and chemotherapy
WANG He；SHENG Jian-wen； YIN Wei -hua；FAN Hui-zhen
Objective To explore the application of Compound Kushen Injection in the treatment of rectal cancer patients with radiotherapy and chemotherapy.Methods A total of 60 patients with rectal cancer in People′s Hospital of Yichun City,Jiangxi Province from December 2018 to August 2020 were selected as subjece and divited into the control group and the observation group according to the random number table method,with 30 cases in each group.The control group received radiotherapy and chemotherapy treatment,and the observation group received Compound Kushen Injection treatment.Both groups received continuous treatment for 6 weeks.The clinical efficacy of the two groups was compared after treatment.The immune function before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results The total clinical effective rate of the observation group after treatment was 93.33%,higher than that of the control group of 66.66%,the difference was statistically significant(P＜0.05).The peripheral blood CD4+,CD4+/CD8+ levels of patients of the two groups after treatment were lower than those before treatment,the peripheral blood CD4+ and CD4+/CD8+ levels of the observation group after treatment were higher than those of the control group,the differences were statistically significant(P＜0.05).The peripheral blood CD8+levels of patients in the two group after treatment were higher than those before treatment,and the peripheral blood CD8+ level of the observation group was lower than that of the control group after treatment,and the differences were statistically significant(P＜0.05).There were no significant differences in the levels of peripheral blood CD4+,CD8+,CD4+/CD8+ between the two groups before treatment(P＞0.05).During the treatment period,the total incidence of adverse reactions in the observation group was 30.00%,which was lower than 66.67% in the control group,the difference was statistically significant(P＜0.05).Conclusion Compound Kushen Injection can improve the immune function of patients with rectal cancer,reduce the side effect of radiotherapy and chemotherapy,and can improve the clinical efficacy of radiotherapy and chemotherapy,which is safer.
2021 Vol. 28 (26): 123-125转133 [Abstract] ( 53 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
126 Application of air pressure therapy in patients with cervical cancer undergoing radiotherapy
ZHU Shu-fang；LIU Hua-zhi； HUANG Chun-lan
Objective To investigate the application effect of air pressure therapy in patients with cervical cancer radiotherapy.Methods A total of 74 patients with cervical cancer who were received radiotherapy in Ganzhou Cancer Hospital from May 2018 to August 2020 were selected as the research subjects.They were divided into two groups according to a random number table method,with 37 cases in each group.All patients were given rehydration,anti-infection and other treatments.On this basis,patients in the control group were helped to turn over once every 2 hours after radiotherapy.The lower limbs of the patients were raised,the lower limbs were massaged,and the patients got out of bed 2-3 days after radiotherapy,the nutritional support were strengthened,and the warm measures were takened.The observation group was treated with air pressure therapeutic apparatus on the basis of the control group.The treatment effect,activeated partial thromboplasting time(APTT),lower extremity condition,blood flow velocity of lower extremity vein and circumference of lower extremity before and after treatment were compared between the two groups.Results The total effective rate of observation group(94.59%)was higher than that of control group(72.97%),and the difference was statistically significant(P＜0.05).The rates of lower extremity swelling,lower extremity pain and thrombosis of the observation group(2.70%,2.70%,0.00%)were lower than those in the control group(21.62%,24.32%,16.22%),and the differences were statistically significant(P＜0.05).APTT of the observation group on 1,7 and 14 days after treatment was shorter than that of the control group,and the differences were statistically significant(P＜0.05).After treatment,the blood flow velocity of lower extremity vein in the observation group was higher than that in the control group,and the circumferential diameter of lower extremity was shorter than that in the control group,and the differences were statistically significant(P＜0.05).Conclusion Air pressure therapy intervention for on cervical cancer after radiotherapy can effectively reduce the incidence rate of swelling,pain and venous thrombosis of the lower extremities,and which can increase the venous blood flow velocity of the lower extremities.
2021 Vol. 28 (26): 126-129 [Abstract] ( 58 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
130 Effect of hepatic artery chemoembolization combined with radiofrequent ablation on serum T lymphocyte subsets and transforming growth factor β1 levels in patients with hepatocellular carcinoma
SHEN Rui-chao； XIONG Gong-peng； HOU Mo-long ；LU Hao
Objective To investigate the effect of transcatheter arterial chemoembolization(TACE)combined with radiofrequent ablation(RFA)in the treatment of patients with liver cancer.Methods A total of 61 patients with liver cancer admitted to the Department of Liver Surgery of Xiamen Hospital of Traditional Chinese Medicine from December 2017 to July 2020 were selected as the research subjects.According to the random number table method,they were divided into the control group(30 cases)and the observation group(31 cases).The control group was treated with TACE,and the observation group was treated with RFA based on the control group.The clinical efficacy,immune function and growth factors of the two groups were compared.Results After treatment,the total effective rate of observation group(61.29%)was higher than that of control group(36.67%),and the difference was statistically significant(P＜0.05).CD3+,CD4+,CD4+/CD8+in the observation group were higher than those in the control group,and CD8+was lower than that in the control group,the differences were statistically significant(P＜0.05).The levels of transforming growth factor β1(TGF-β1)and vascular endothelial cell growth factor(VEGF)in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion TACE combined with RFA in the treatment of liver cancer has a significant effect,which can improve the immune function of patients and regulate the level of growth factors.
2021 Vol. 28 (26): 130-133 [Abstract] ( 49 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
134 Effect of percutaneous microwave ablation for low -risk thyroid micropapillary carcinoma and its impact on quality of life
LI Ji-sheng
Objective To investigate the effect of percutaneous microwave ablation for low-risk thyroid micropapillary carcinoma and its effect on quality of life.Methods A total of 80 low-risk thyroid micropapillary carcinoma patients admitted to Anshan Cancer Hospital from December 2019 to December 2020 were selected as the research subjects,and divided into the observation group(40 cases)and the control group(40 cases)according to the method of drawing lots.The observation group was treated with percutaneous microwave ablation,and the control group was treated with open surgery.The total effective rate,incidence of adverse reactions and quality of life of the two groups were compared.Results The total effective rate of observation group was higher than control group,the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).After treatment,the physical,psychological,social and material life scores of the observation group were higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion The effect of percutaneous microwave ablation in the treatment of low-risk thyroid micro papillary carcinoma is very significant,and it can improve the quality of life score of patients.
2021 Vol. 28 (26): 134-136 [Abstract] ( 50 ) HTML (29 KB)  PDF  (0 KB)  ( 4 )
137 Clinical effect of Pemetrexed combined with Cisplatin in patients with lung adenocarcinoma and its effect on the levels of thyroid transcription factor-1 and neuron-specific enolase
WU Hua
Objective To explore the clinical effect of Pemetrexed combined with Cisplatin in patients with lung adenocarcinoma and its effect on the levels of thyroid transcription factor-1(TTF-1)and neuron-specific enolase(NSE).Methods Seventy-eight patients with lung adenocarcinoma treated in Loudi Central Hospital from September 2017 to December 2019 were selected as research subjects,and were retrospectively analyzed.According to different treatment methods,patients were divided into control group(n=39)and study group(n=39).The Docetaxel combined with Cisplatin was given to the control group,and the Pemetrexed combined with Cisplatin was given to the research group.The objective response rate(ORR)and the disease control rate(DCR)in the two groups were observed.The occurrence of adverse reactions was compared between the two groups.The levels of tumor markers(serum TTF-1 and serum NSE)were compared between the two groups.Results The ORR and DCR in the research group were higher than those in the control group,with statistically significant differences(P＜0.05).The incidence rates of adverse reactions in the research group were lower than those in the control group,with statistically significant differences(P＜0.05).The serum TTF-1 and serum NSE levels after treatment in the research group were lower than those in the control group,with statistically significant differences(P ＜0.05).Conclusion In patients with lung adenocarcinoma,the combined use of Pemetrexed and Cisplatin can improve the efficacy,with fewer adverse reactions,and can also reduce the levels of serum TTF-1 and serum NSE.
2021 Vol. 28 (26): 137-140 [Abstract] ( 49 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
141 Clinical effect of laparoscopic ovarian cystectomy in the treatment of ovarian cysts
YUAN Li ；DING Xiao-yan ；LIU Ting
Objective To investigate the clinical effect of laparoscopic ovarian cystectomy in the treatment of ovarian cysts.Methods A total of 106 patients with ovarian cyst admitted to the Affiliated Hospital of Zunyi Medical University from January 2018 to November 2020 were retrospectively selected as the study subjects,and divided into the observation group(53 cases)and the control group(53 cases)according to different surgical methods.The observation group was treated with laparoscopic ovarian cystectomy,and the control group was treated with open ovarian cystectomy.The operation time,hospital stay,first exhaust time,intraoperative blood loss,time out of bed,postoperative complications and the recovery of ovarian function were compared between the two groups.Results The operation time,hospitalization time,first exhaust time and ambulation time of the observation group were shorter than those of the control group,and the intraoperative blood loss of the observation group was less than that of the control group,the differences were statistically significant(P＜0.05).The levels of serum luteinizing hormone,follicle stimulating hormone and estradiol in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Minimally invasive surgery for patients with ovarian cysts can effectively reduce the cost of surgery,reduce the operation time and the length of hospitalization,and the postoperative ovarian function recovers well,with fewer complications,safe and effective,and it is worthy of popularization.
2021 Vol. 28 (26): 141-143转147 [Abstract] ( 55 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
144 Comparison of the effect of two different pregnancy aid regimens in patients with previous pregnancy aid failure with long-term early follicular phase
HUANG Yun； SHUAI Mei ；YUE Lin-lin
Objective To explore the application effect of two different pregnancy aid regimens in patients with previous pregnancy aid failure with long-term early follicular phase.Methods From January 2019 to December 2020,a total of 122 patients admitted to Ganzhou Maternal and Child Health Hospital,who had failed the previous in-vitro fertilization-embryo transfer assisted pregnancy and received the second assisted pregnancy were selected as the research subjects.According to the coin toss method,the patients were divided into group A(52 cases)and group B(70 cases).The patients in group A were treated with the long-term early follicular phase program,and the patients in group B were treated with the antagonist program.The clinical indicators and the results of ovulation induction were compared between the two groups.Results There was no statistical significance in the number of eggs obtained and the number of embryos transferred between the two groups(P＞0.05).The total dose of gonadotropin(Gn)in group B was less than that in group A,and Gn days were shorter than that in group A.The number of 2 prokaryotic embryos,cleavage number and transferable embryos in group B were more than that in group A,the differences were statistically significant(P＜0.05).On Gn initiation day,there was no statistical significance in FSH between two groups(P＞0.05),the levels of estrogen(E2)and luteinizing hormone(LH)in group B were lower than those in group A,the differences were statistically significant(P＜0.05).On the day of human chorionic gonadotropin(HCG)injection,there was no significant difference in endometrial thickness between the two groups(P＞0.05),the levels of E2 and progesterone in group B were higher than those in group A,the differences were statistically significant(P＜0.05).There was no statistical significance in the optimal embryo rate,transplantation rate,blastocyst formation rate and early abortion rate between the two groups(P＞0.05).The cumulative pregnancy rate in group B was higher than that in group A,and the incidence of moderate to severe ovarian hyperstimulation syndrome(OHSS)was lower than that in group A,the differences were statistically significant(P＜0.05).Conclusion For those who have failed the early follicular phase long program,the antagonist program for re-fertilization can effectively increase the cumulative pregnancy rate and reduce the incidence of moderate to severe OHSS,and the effect is significant.
2021 Vol. 28 (26): 144-147 [Abstract] ( 38 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
148 Effect of rehabilitation physiotherapy combined with bodybuilding exercise in the treatment of postpartum rectus diastasis
ZENG Yi； HU Hong-xia
Objective To investigate the effect of rehabilitation physiotherapy combined with bodybuilding exercise in the treatment of postpartum rectus diastasis.Methods A total of 60 patients with postpartum rectus diastasis admitted to Jiangxi Baijia Aima Maternity Hospital between June 2019 and June 2020 were selected as study subjects and divided into the control group(30 cases)and the study group(30 cases)according to random number table method.The control group received routine autonomous training,while the study group received rehabilitation physiotherapy and bodybuilding exercise.Clinical effect of the two groups were recorded.The inter recti distance,waist circumference recovery,lower back pain evaluated by visual analogue scale(VAS)and quality of life evaluated by 36-item short form health survey(SF-36)were compared between the two groups.Results The total response rate in study group was higher than that in control group(P＜0.05).Before treatment,there were no significant differences in inter recti distance,upper umbilical circumference,umbilical circumference and lower umbilical circumference between the two groups(P＞0.05).After treatment,the above indexes in study group were smaller than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in VAS and SF-36 scores between the two groups(P＞0.05).After treatment,the VAS score of the study group was lower than that of thecontrol group,and the SF-36 score was higher than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion Rehabilitation physiotherapy combined with bodybuilding exercise can improve the curative effect on postpartum rectus diastasis,improve the inter-rectus distance and recovery of waist circumference,reduce pain and improve quality of life.
2021 Vol. 28 (26): 148-150转154 [Abstract] ( 65 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
151 A control study on the application of risk early warning assessment management in high risk pregnant women under the “two child” policy
YANG Hong ；LI Li ；XIAO Jie
Objective To explore the effect of risk early warning assessment and management in high-risk pregnant women under the “two child” policy.Methods The clinical data of 76 pregnant women with high risk of second child admitted to Pingxiang Maternal and Child Health Hospital from January to October 2020 were retrospectively analyzed.According to the intervention method,they were divided into control group(38 cases)and observation group(38 cases).The control group adopted the traditional high risk scoring method,and the observation group adopted the risk early warning assessment management intervention method.Risk classification,successful delivery,maternal and infant outcomes,pregnancy comorbidities and complications,and neonatal Apgar score were compared between the two groups.Results The total incidence of high-risk pregnancy in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the successful delivery rate between the two groups(P＞0.05).The total incidence of adverse maternal and infant outcomes in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).The incidence of pregnancy complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in Apgar score 1 min after birth between the two groups(P＞0.05).The Apgar score of the observation group was higher than that of the control group 5 min after birth,the difference was statistically significant(P＜0.05).Conclusion The application of risk early warning assessment management under the "two child" policy in high-risk pregnant women has good effect,the total incidence of high-risk pregnancy is low,the successful delivery rate is high,and the maternal and infant outcomes are good.
2021 Vol. 28 (26): 151-154 [Abstract] ( 37 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
155 Clinical effect of Tongqiao Biyan Tablets combined with Pidotimod in treatment of allergic rhinitis in children
WANG Qing； ZHAO Jian-bo
Objective To explore the clinical effect of Tongqiao Biyan Tablets combined with Pidotimod Oral Liquid in the treatment of allergic rhinitis in children.Methods A total of 84 children with allergic rhinitis admitted in the Second People′s Hospital of Yichun City from January 2020 to September 2020 were selected as the research subjects,and they were divided into the control group(42 cases)and the study group(42 cases)by random number table method.The control group was treated with Pidotimod Oral Liquid,and the study group was treated with Tongqiao Biyan Tablets combined with Pidotimod Oral Liquid.The clinical effect,levels of inflammatory cytokine,clinical symptom scores and adverse reactions were compared between the two groups.Results The total effective rate in the study group was 92.86%,which was higher than that in the control group(76.19%),and the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in the levels of interleukin-5(IL-5)and tumor necrosis factor-α(TNF-α)between the two groups(P＞0.05).After treatment,the levels of IL-5 and TNF-α in the study group were(10.21±0.87)pg/ml and(26.29±3.67)mg/ml,respectively,which were lower than those in the control group of(12.36±1.26)pg/ml and(36.51±4.64)mg/ml,with statistical significances(P＜0.05).Before treatment,there were no significant differences in sneeze frequency score,nasal overflow score,nasal obstruction score and the total score between the two groups(P＞0.05).After treatment,the sneeze frequency score,nasal overflow score,nasal congestion score and total score of the study group were(0.92±0.08),(1.12±0.11),(1.04±0.13),(3.08±0.32)points,respectively,which were lower than those in the control group of(1.36±0.18),(1.64±0.21),(1.67±0.24)and(4.67±0.63)points,with statistical significances(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Tongqiao Biyan Tablets combined with Pidotimod Oral Liquid can effectively relieve the clinical symptoms of allergic rhinitis in children,reduce the level of inflammatory cytokin,and has obvious effect and high application value.
2021 Vol. 28 (26): 155-158 [Abstract] ( 46 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
159
Tangent analysis and the occurrence of genetic mutations of glucose-6-phosphate dehydrogenase deficiency screening method for newborns in Jiangmen city
Tangent analysis and the occurrence of genetic mutations of glucose-6-phosphate dehydrogenase deficiency screening method for newborns in Jiangmen city[J]. 中国当代医药, 2021,28(26): 159-163')" href="#"> YANG Ying-song； ZHONG Zhi-lai； YANG Mei ；TAN Jie-liang； LIU Ying-yan； ZENG Qin-long； LI Zhi-ming； TANG Jia
Objective To investigate the genetic mutations of glucose 6-phosphate dehydrogenase(G6PD)in newborns in Jiangmen city,and to explore the cut-off value of G6PD fluorescence quantitative screening in Jiangmen city.Methods From January 2018 to May 2020,113 665 cases of newborns with blood spots who were screened in the Neonatal Genetic Metabolic Disease Screening Center in Jiangmen City were selected as the study subjects for retrospective analysis,and G6PD detection and screening were performed by fluorescence quantitative method.A total of 889 cases of recalled G6PD screening positive newborns were selected as suspected G6PD deficiency(G6PDd)newborns for investigation,and their venous blood was collected for G6PD enzyme activity or hot spot gene mutation detection.The results of G6PD fluorescence quantitative screening in all newborns were counted,and the results of hot spot gene mutation detection and G6PD enzyme activity diagnosis in newborns suspected of G6PDd were counted.At the same time,889 newborns suspected of G6PDd and 2839 newborns initially screened with G6PD negative were followed up,ROC curve was used to analyze the cut-off value of G6PD fluorescence quantitative method.Results In Jiangmen city,the positive rates of male and female were 7.01% and 1.51%,respectively,and the overall positive rate of screening was 4.39%.Of 889 newborns suspected of G6PDd,222 newborns were tested for hot spot gene mutation detection,and the mutations were detected in 220 cases.Hemizygous mutation in 188 male infants,the detection rates of c.1388G>A,c.1376G>T,c.95A>G,c.871G>A,c.1024C>T,c.392G>T,c.1360C>T,c.1004C>A were high,accounted for 94.68%of male mutation sites detected.Enzyme activity was confirmed in 835 cases,and there were 801 confirmed positive cases.ROC curve analysis of G6PD fluorescence quantitative screening values showed that the maximum AUC values of male and female were 0.992 and 0.888,respectively,and the corresponding G6PD cut-off values were 2.98 and 2.97 U/g Hb,respectively.Conclusion The occurrence of neonatal G6PD gene mutation in Jiangmen is at a moderate level,in which c.1388G＞A,c.1376G＞T,c.95A＞G,c.871G＞A,c.1024C＞T,c.392G＞T,c.1360C＞T,c.1004C＞A are the main mutation sites.It is suggested that 3.0 U/g Hb should be used as the cut-off value for the fluorescence quantitative screening of G6PD in Jiangmen city.
2021 Vol. 28 (26): 159-163 [Abstract] ( 58 ) HTML (37 KB)  PDF  (0 KB)  ( 9 )
164 Application effect of lactose free diet supplementary program in children with rotavirus enteritis
ZHANG Ying； HUANG Ming-jian
Objective To explore the application effect of lactose free diet supplementary program in children with rotavirus enteritis.Methods Clinical data of 60 children with rotavirus enteritis admitted to the Department of Pediatrics,Maternal and Child Health Hospital of Haizhu District,Guangzhou from October 2019 to October 2020 were retrospectively analyzed.According to the treatment method,they were divided into control group(30 cases)and experimental group(30 cases).The control group was treated with xiaoxie Sustop granule,and the experimental group was treated with lactose free diet on this basis.Laboratory indexes,total effective rate,clinical related indexes(time to stop diarrhea,time to improve vomiting symptoms,time to recover stool traits)and the occurrence of adverse reactions were compared between the two groups.Results After treatment,C-reactive protein level and serum white blood cell count in the experimental group were lower than those in the control group,the differences were statistically significant(P＜0.05).The total effective rate of the experimental group(96.67%)was higher than that of the control group(73.33%),the difference was statistically significant(P＜0.05).The antidiarrheal time,vomiting symptom improvement time,fever reduction time and stool recovery time of the experimental group were shorter than those of the control group,the differences were statistically significant(P ＜0.05).The incidence of adverse reactions in the experimental group was 3.33%,lower than that in the control group(30.00%),the difference was statistically significant(P＜0.05).Conclusion The application of lactose free dietary control auxiliary program in children with rotavirus enteritis has significant effect,can improve inflammatory factors and clinical symptoms,and high safety.
2021 Vol. 28 (26): 164-166转170 [Abstract] ( 52 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
167 Comparison of the effect of hysteroscopic electroresection and clamping in the treatment of infertility of endometrial polyps
WEI Feng-jiao； XU Yan-ping； WU Jia-ni
Objective To compare the effect of hysteroscopic electroresection and clamping in the treatment of infertility of endometrial polyps.Methods The clinical data of 108 cases of infertility patients with intrauterine polyp admitted to Xiamen Xianyue Hospital from March 2018 to April 2019 were retrospectively analyzed.According to different surgical procedures,they were divided into observation group and control group,with 54 patients in each group.The observation group was treated with hysteroscopic electroresection,and the control group was treated with hysteroscopic clamps.Surgical indexes,menstrual volume and endometrial thickness were compared between the two groups.Results There was no statistical significance in the length of stay,operation time and intraoperative blood loss between the two groups(P＞0.05).One month after surgery,the menstrual volume and endometrial thickness of the observation group were less than those of the control group,the differences were statistically significant(P＜0.05).The recurrence rate of observation group was lower than control group 6 months after operation,the difference was statistically significant(P＜0.05).There was no significant difference in the recurrence rate between the two groups 6 to 12 months after operation(P＞0.05).There was no significant difference in pregnancy rate between the two groups 6 months after operation(P＞0.05).The pregnancy rate of observation group was higher than control group 6 to 12 months after operation,the difference was statistically significant(P ＜0.05).Conclusion The effect of hysteroscopic electroresection of endometrial polyps with infertility is better than that of clamp surgery,the postoperative pregnancy rate is high,the recurrence rate is low,and the regulation of patients′ menstrual volume is better.
2021 Vol. 28 (26): 167-170 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
171 Application of pelvic floor static and dynamic MRI in female patients with chronic pelvic pain syndrome
CHEN Can； GUO Hai-xia； WANG Yuan-ju
Objective To explore the value of static and dynamic magnetic resonance imaging(MRI)in female patients with chronic pelvic pain syndrome(CPPS).Methods A total of 30 patients with CPPS admitted to Bao′an District Central Hospital of Shenzhen from January 2019 to May 2020 were selected as the study group,meanwhile 30 patients with normal pelvic floor function at the same period were chosen as the control group.Both groups were examined by static and dynamic MRI of pelvic floor function,and the imaging characteristics were compared between the two groups.Results The anteroposterior diameter of the levator ani hiatus in the study group was shorter than that in the control group,the area of the levator ani hiatus in the study group was shorter than that in the control group,the anal lift muscle thickness in the study group was thicker than that in the control group,with statistically significant differences(P＜0.05).There were no significant difference in the area of pubococcygeus,iliococcygeus,pubis straighmuscle,and the length of H-line,M-line between the two groups(P＞0.05).Conclusion The imaging features of pelvic floor static and dynamic MRI in the onset of CPPS were spasmodic changes of levator ani muscle,which has guiding significance.
2021 Vol. 28 (26): 171-173转177 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
174 Effect of magnesium sulfate on neonatal hypoxic-ischemic encephalopathy
YANG Yi-hua
Objective To investigate the effect of magnesium sulfate in the treatment of neonatal hypoxic-ischemic encephalopathy.Methods A total of 64 asphyxia neonates born in the Department of Obstetrics and Gynecology of Fukuang General Hospital from February 2018 to August 2019 were selected as the research subjects.They were randomly divided into the treatment group(n=32)and the control group(n=32).The control group was given conventional treatment.The treatment group was additionally given magnesium sulfate treatment on the basis of the control group.The clinical efficacy,clinical symptoms improvement time,Mg2+ level,pH level of arterial blood gas and human S100-B protein(S100-B)level,the pediatric growth and development(Gesell developmental scale score),and the occurrence of adverse reactions of the two groups were observed.Results The total effectiveness rate of the treatment group was 93.75%,higher than that of 71.88% of the control group,with statistical significance(P＜0.05).The improvement time of muscular tension,primitive reflex and state of consciousness in the treatment group was shorter than that of the control group,with statistical significance(P＜0.05).The comparison of arterial blood gas pH,Mg2+ level,and S100-B level before treatment between the two groups of children was not statistically significant(P＞0.05).The arterial blood gas pH and Mg2+ levels in the treatment group at 2 and 6 d after treatment were higher than those before treatment and the control group,and the level of S100-B was lower than that before treatment and the control group,with statistical significance(P＜0.05).The arterial blood gas pH and Mg2+ of the control group at 6 d after treatment were higher than those before treatment,and the level of S100-B was lower than that before treatment,with statistical significances(P＜0.05).After 8 months of follow-up,the Gesell score of the treatment group was higher than that of the control group,with statistical significance(P＜0.05).One case of hypotension occurred in the treatment group,and the control group had no adverse reactions,total incidence of adverse reactions was compared between the two groups,the difference was not statistically significant(P＞0.05).Conclusion Magnesium sulfate can effectively improve the clinical symptoms of neonates with hypoxic-ischemic encephalopathy,shorten the course of the disease,promote the recovery of nerve function in high safety.
2021 Vol. 28 (26): 174-177 [Abstract] ( 46 ) HTML (37 KB)  PDF  (0 KB)  ( 9 )
178 Etiological characteristics and treatment of common viral respiratory tract infection in children
MAO Ai-jun； LIU Hong-fei； CHEN Zheng
Viral respiratory tract infection is the most common disease in pediatric clinic,it ranks first in pediatric cases,which seriously threatens the health and safety of children.There are many types of viruses causing respiratory tract infection,including Respiratory Syncytial Virus,Influenza Virus,Parainfluenza Virus,Rhinovirus,Adenovirus and so on.The characteristics of etiology and epidemiology of common respiratory viruses are summarized in this paper,and the clinical features,treatment and prevention measures of that are researched,and the commonly used drugs,doses and precautions of the treatment of respiratory tract infections are proposed.This paper has a certain guiding significance for the diagnosis and treatment,rational drug use,prevention and control of respiratory tract infections,especially for rural or remote areas that do not have the conditions for pathogenic examination.
2021 Vol. 28 (26): 178-181 [Abstract] ( 51 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
182 Nutrition status of serum vitamin A and E in pregnant women and health education in a hospital
XU Shu-yun； HE Hui-min； HU Dan
Objective To study the nutrition status of serum vitamin A and E in pregnant women in a hospital of Dalian for the purpose of scientific basis for preventing vitamin A and E deficiency.Methods The basic information and blood samples of 3648 pregnant women who tested in Dalian Maternal and Child Health Care Hospital from January to December 2018 were retrospective and analyzed.The levels of serum vitamin A and E was tested by chemiluminescence method,and the differences of the levels of serum vitamin A and E were compared.Results The average level of serum vitamin A in 3648 pregnant women was(0.28±0.08)mg/L,and the deficiency rate was 7.2%.The average level of serum vitamin E in 3517 pregnant women was(12.28±2.95)mg/L,all of them were at adequate levels.Divided the pregnant women into three groups according to their age,the levels of vitamin A was compared in the three groups,the differences were statistically significant(P＜0.05);and the deficiency rate of vitamin A was compared in the three groups,with no statistical significance difference(P＞0.05).The level and deficiency rate of vitamin A was compared in different seasons,the differences were statistical significance(P＜0.05),the highest deficiency rate of vitamin A was in spring(9.1%),followed by summer(8.2%).Divided the pregnant women into three groups according to their age,the levels of vitamin E was compared in the three groups,the differences were statistically significant(P＜0.05);the level of vitamin A was compared in different seasons,the difference was statistical significance(P＜0.05).Conclusion The deficiency of vitamin A and the overdose of vitamin E in pregnant women aged older than 35 years should be taken more attention,and the clinical health care and health education strategy should be adjusted in time for the high vitamin A deficiency rate of pregnant women in spring and summer in clinical work.
2021 Vol. 28 (26): 182-184 [Abstract] ( 57 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
185 Effect of Dexamethasone combined with Xueshuantong atomization inhalation on postoperative vocal cord polyps of qi stagnation and blood stasis type
XIONG Mei-hua； HU Shi-ping ；LI Wen-hui
Objective To explore the application effect of Dexamethasone combined with Xueshuantong atomization inhalation in postoperative vocal cord polyps of qi stagnation and blood stasis type.Methods From January 2019 to October 2020,60 patients with vocal cord polyps with qi stagnation and blood stasis were selected as research objects,and were divided into observation group(n=30)and control group(n=30)according to random number table method.The control group were treated with Dexamethasone,and the observation group were treated with Xueshuantong atomization inhalation on the basis of the control group after operation.The curative effect and adverse reactions of the two groups were compared.Results The total effective rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Compared with traditional Dexamethasone atomization inhalation,Xueshuantong atomization inhalation can significantly improve the curative effect of patients and reduce adverse reactions such as dry mouth,which is worthy of clinical application.
2021 Vol. 28 (26): 185-187 [Abstract] ( 87 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
188 Correlation analysis of idiopathic macular epiretinal membrane with ocular vision and color vision
LIN Nan； LIU Li； TIAN Jie； LEI Xiao-jun ；HU Yue-ping
Objective To analyze the correlation between the macular microstructure of the idiopathic macular epiretinal membrane(IMEM)and ocular vision and color vision.Methods A total of 30 monocular IMEM patients(60 eyes)who were admitted to Department of Ophthalmology of Dalian Friendship Hospital from January 2019 to January 2021 were selected as the research subjects.According to whether these eyes with IMEM or not,they were divided into IMEM eye group and control group,with 30 eyes in each group.The best correlated visual acuity(BCVA)of the two groups were observed,the color vision was examined by Farnsworth Munsell 100 Hue Test(FM 100 Hue Test),and central foveal thickness(CFT)was examined by frequency domain optical coherence tomography(SD-OCT).The continuity of ellipsoid zone(EZ)in macular area was observed and analyzed statistically.Results The BCVA of IMEM eye group was lower than control group,the color vision score was higher than control group,the CFT was thicker than control group,the differences were statistically significant(P＜0.05).BCVA with complete EZ continuity was higher than that with EZ continuity interruption,and the color vision score was lower than that with EZ continuity interruption,the differences were statistically significant(P＜0.05).CFT and IMEM grades were positively correlated with BCVA and color vision scores(P＜0.05),and age was positively correlated with color vision scores(P＜0.05).Conclusion BCVA and color vision of IMEM eyes were lower than control eyes,and CFT were thicker than control eyes.The elder the age,the higher the grade of IMEM and the thicker CFT,as well as the worse BCVA and color vision.BCVA and color vision of IMEM with continuous EZ were better than those with discontinuous EZ.
2021 Vol. 28 (26): 188-190转194 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
191 Correlation between carotid intima-media thickness,ankle-brachial index and the degree of coronary artery disease in patients with periodontal disease
ZHANG Fu-lan ；WANG Sheng-nan； JIN You-ren
Objective To investigate the correlation between carotid intima-media thickness(CIMT),ankle-brachial index(ABI)and the degree of coronary artery disease in patients with periodontal disease.Methods A total of 180 patients with periodontal disease admitted to Hankou Hospital of Wuhan City from February 2018 to December 2019 were selected as the research objects.According to the Gensini scores,they were divided into normal group(n=40,Gensini score=0),group A(n=35,Gensini score＞0-36),group B(n=37,Gensini score＞36-78),group C(n=32,Gensini score＞78-117)and group D(n=36,Gensini score＞117-160).The CIMT,ABI,and Gensini scores of these group were compared.The Spearman method was used to analyze the correlation between ABI,CIMT,and Gensini scores in patients with periodontal disease and coronary artery disease.The ROC curve method was used to analyze ABI,CIMT and Gensini scores to predict the clinical value of coronary artery disease with periodontal disease.Results There was no statistically significant difference between the ABI of group A and the normal group(P＞0.05),the ABI of groups B,C,and D were all lower than the normal group,and the CIMT and Gensini scores were higher than those of the normal group,and the difference was statistically significant(P＜0.05).In patients with periodontal disease and coronary artery disease,ABI was negatively correlated with Gensini score(r=-0.602, P＜0.05),and CIMT was positively correlated with Gensini score(r=0.651, P＜0.05).The AUC,sensitivity and specificity for ABI,CIMT respectively predicting periodontal disease combined with coronary artery disease were lower compared with Gensini score,and the differences were statistically significant(P＜0.05).There were no significant differences in AUC,sensitivity,specificity and Gensini score of ABI combined with CIMT in predicting periodontal disease with coronary artery disease(P＜0.05).Conclusion CIMT and ABI are closely related to the degree of coronary artery disease in patients with periodontal disease.The clinical value of ABI combined with CIMT in predicting periodontal disease with coronary artery disease is similar to the Gensini score and has better application value.
2021 Vol. 28 (26): 191-194 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
195 Comparison of the effect of single-visit and multiple-visit root canals in the treatment of acute pulpitis
CHEN Hao
Objective To compare the effects of the single-visit and multiple-visit root canals in the treatment of acute pulpitis.Methods A total of 100 patients with acute pulpitis(120 co-affected teeth)who were admitted to Fushun Stomatological Hospital from March 2018 to May 2019 were selected as the research subjects.They were divided into the control group(n=50,60 co-affected teeth)and the experimental group(n=50,60 co-affected teeth)according to the random number table method.The control group were treated with multiple-visit root canal treatment,and the experimental group was treated with one-time root canal treatment.The clinical effect,total incidence of adverse reactions,quality of life between the two groups were compared.Results The overall response rate of the experimental group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The total adverse reaction rate of the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The scores of psychological function,social function,role function,and physical function in the experimental group after treatment were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Compared with multiple-single root canal treatment,the use of single-visit root canal in the treatment of patients with acute pulpitis obtains a more remarkable clinical effect and fewer adverse reactions,which is beneficial to improve the quality of life of patients and is worthy of extensive use in clinical practice.
2021 Vol. 28 (26): 195-197 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
198 Clinical study of acupoint application combined with Gastrodin and Xuesaitong in the treatment of vertebrobasilar artery insufficiency vertigo
HUANG Yu-huan； DUAN Xiao-lin； HU Xiao-hua ；HE Wei-jian； HUANG Li-min
Objective To explore the effect of acupoint application combined with Gastrodin and Xuesaitong in the treatment of vertigo due to vertebra-basal artery insufficiency.Methods A total of 70 patients with vertigo due to vertebral-basilar artery insufficiency admitted to the Department of Internal Medicine of Fuzhou Hospital of Traditional Chinese Medicine from May 2019 to June 2020 were selected as the research objects and divided into the control group and the observation group by random number table method,with 35 cases in each group.The control group was treated with Gastrodin and Xuesaitong,and the observation group was treated with acupoint application combined with Gastrodin and Xuesaitong for 10 days.The mean blood velocity(Vm)of the left vertebral artery(LVA),right vertebral artery(RVA)and basilar artery(BA),blood viscosity before and after treatment and clinical efficacy were compared between the two groups.Results Before treatment,there were no statistically significant differences in Vm of LVA,RVA and BA between the two groups(P＞0.05).After treatment,the Vm of LVA、RVA、BA in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no statistically significant differences in the comparison of whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity between the two groups(P＞0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).Conclusion Acupoint application combined with Gastrodin and Xuesaitong in the treatment of vertebrobasilar insufficiency vertigo can effectively improve hemorheology,promote blood circulation,improve curative effect and has good safety.
2021 Vol. 28 (26): 198-201 [Abstract] ( 54 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
202 Clinical effect of Huangqi Jiedu Decoction on postoperative recurrence and metastasis of triple-negative breast cancer
CHI Yan-jun；LIU Ning；YANG Zhe

Objective To investigate the clinical effect of Huangqi Jiedu Decoction on recurrence and metastasis of triple negative breast cancer after operation.Methods A total of 56 patients with primary triple negative breast cancer who were treated in Dalian Hospital of Integrated Traditional Chinese and Western Medicine from February 2016 to February 2018 were selected as the research objects and divided into the control group and the observation group by computer random grouping method,with 28 cases in each group.The control group was treated with Paclitaxel periodic chemotherapy or surgery,and the observation group was treated with Huangqi Jiedu Decoction on the basis of the control group.Serum tumor markers,solid tumor volume under computed tomography(CT),adverse reactions and longterm treatment results were compared between the two groups before and after treatment.Results After treatment,the carbohydrate antigen 153(CA153)and carcinoembryonic antigen(CEA)in the observation group were higher than those in the control group,the solid tumor volume under CT was smaller than that in the control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05).The recurrence and metastasis rates of observation group at 6,12 and 18 months after treatment were lower than those of the control group,the differences were statistically significant(P＜0.05).Conclusion In the treatment of triple negative breast cancer patients with postoperative recurrence and metastasis,the use of Huangqi Jiedu Decoction can not only effectively reduce the CA153 and CEA values of patients,but also reduce the probability of postoperative adverse reactions,and help to reduce the probability of postoperative recurrence and metastasis.
2021 Vol. 28 (26): 202-204转208 [Abstract] ( 70 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
205 Study on the efficacy of application of Feitai Capsules in the retreatment of pulmonary tuberculosis patients
JIA Wen-cheng； LU Guan-nan
Objective To investigate the efficacy of application of Feitai Capsules in the retreatment of pulmonary tuberculosis patients.Methods A total of 80 patients of retreated tuberculosis admitted to the Fourth Hospital of Chaoyang City from January 2019 to January 2020 were selected as the research objects.According to the random number table method,the patients were divided into the control group(40 cases)and the experimental group(40 cases).The control group used routine anti-tuberculosis drug treatment,the experimental group adopted the method of adding Feitai Capsules treatment on the basis of conventional anti-tuberculosis drugs.The index of cardiopulmonary function,serum inflammatory factor levels and clinical efficacy were compared between the two groups.Results The levels of oxygen partial pressure,forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),FEV1/FVC after treatment in the experimental group were higher than those in the control group,the levels of carbon dioxide partial pressure,tumor necrosis factor α(TNF-α),interleukin 6(IL-6),interleukin 8(IL-8),and C-reactive protein(CRP)after treatment in the experimental group were lower than those in the control group,the differences were statistically significant(P＜0.05).There were no significant difference in the levels of oxygen partial pressure,FEV1,FVC,FEV1/FVC,carbon dioxide partial pressure,TNF-α,IL-6,IL-8,CRP before treatment in the two groups(P＞0.05).The levels of oxygen partial pressure,FEV1,FVC,FEV1/FVC after treatment in the two groups were higher than those before treatment,the levels of partial pressure of carbon dioxide,TNF-α,IL-6,IL-8,and CRP after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).The total clinical effective rate of the experimental group(90%)was higher than that of the control group(70%),the difference was statistically significant(P＜0.05).Conclusion Feitai Capsules has a significant effect in the treatment of patients with retreatment of pulmonary tuberculosis.Combined use with conventional anti-tuberculosis drugs can effectively improve the cardiopulmonary function and related serum indicators of patients,and it is worthy of clinical application and promotion.
2021 Vol. 28 (26): 205-208 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
209 Clinical effect of integrated traditional Chinese and Western medicine in the treatment of lower extremity deep venous thrombosis
XIAO Ling； ZHENG Guang-ru； JIANG Qiu-hong
Objective To explore the clinical effect of integrated traditional Chinese and Western medicine in the treatment of lower extremity deep venous thrombosis.Methods The clinical data of 60 patients with lower extremity deep venous thrombosis who were admitted from June 2017 to October 2019 in the Department of Vasculature of the Second Hospital of Sanming City were selected and analyzed retrospectively.The 60 patients were divided into the observation group and the control group according to different treatment methods,with 30 cases in each group.Both groups were given comprehensive treatment.The control group was treated with subcutaneous injection of Low-Molecular-Weight Heparin Sodium injection and oral Warfarin tablets on the basis of comprehensive treatment.On the basis of the control group,the observation group was given traditional Chinese medicine for oral administration and selfmade modified Huoxue Zhitong prescription based on different syndromes,and external application of Chinese medicine to the affected area.Thirty days lasted a course of treatment.The two groups were both treated for a course of treatment and the results were observed and compared.Results The total effectiveness rate of the observation group was 93.33%,which was higher than 73.33% of the control group,with statistical significance(χ2=4.320, P＜0.05).After treatment,thigh circumference difference of the observation group was(1.24±0.45)cm,which was smaller than(1.56±0.46)cm of the control group,with statistical significance(t=2.750, P＜0.01).The calf circumference difference of the observation group was(1.06±0.43)cm,which was smaller than(1.44±0.58)cm of the control group,with statistical significance(t=2.865, P＜0.01).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Integrated traditional Chinese and Western medicine in the treatment of lower extremity deep venous thrombosis is beneficial to enhance the curative effect and reduce the formation of sequelae of lower extremity deep venous thrombosis,which is worthy of clinical promotion.
2021 Vol. 28 (26): 209-212 [Abstract] ( 55 ) HTML (38 KB)  PDF  (0 KB)  ( 9 )
213 Study on the value of combined detection of IL-2,IL-8 and CA153 in the diagnosis of breast cancer
ZHU Chun-long； ZHANG Yang-lin； WAN Ren-jie； DENG Yao； LI Qing-xiang
Objective To investigate the value of combined detection of interleukin-2(IL-2),interleukin-8(IL-8)and carbohydrate antigen 153(CA153)in the diagnosis of breast cancer.Methods Serum samples were collected from 65 patients with breast cancer,40 patients with benign breast tumor and 40 healthy subjects admitted to the Third Hospital of Nanchang City from June 2019 to December 2020.ELISA method and chemiluminescence method were used to detect serum levels of IL-2,IL-8 and CA153,respectively.In combination with IL-2,IL-8 and CA153,the receiver operating characteristic(ROC)curve was plotted in medcale software to calculate the diagnostic value and diagnostic efficacy of each indicator in the diagnosis of breast cancer.Results The level of IL-2 in the breast cancer group was lower than that in the benign breast tumor group and the healthy health group,and the level of IL-2 in the benign breast tumor group was lower than that in the healthy health group,the differences were statistically significant(P＜0.05).The levels of IL-8 and CA153 in the breast cancer group were higher than those in the benign breast tumor group and the healthy health group,and the level of IL-8 in the benign breast tumor group was higher than that in the healthy health group,the differences were statistically significant(P＜0.05).The area under ROC curve(AUC)of IL-2,IL-8 and CA153 detected by the combination was larger than that detected by each indicator alone.Conclusion The combined detection of serum IL-2,IL-8 and CA153 has a good value in the diagnosis of breast cancer.
2021 Vol. 28 (26): 213-215转219 [Abstract] ( 60 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
216 Diagnostic value comparison of effector T cell spot test of alveolar lavage fluid and RNA constant temperature amplification real-time fluorescence detection for smear-negative pulmonary tuberculosis
HUANG Jian； ZHANG Zhi-da； LI Xi-jiu
Objective To compare the diagnostic value of effector T cell spot test(T-SPOT)of alveolar lavage fluid and RNA constant temperature amplification real-time fluorescence detection(STA-TB)for smear-negative pulmonary tuberculosis.Methods Eighty patients with suspected tuberculosis who were admitted to Jiangxi Chest Hospital from January to December 2019 were selected.Sputum smears showed that there were 35 cases in the smear-positive group,and 45 cases in the smear-negative group.The molecular biological examination of 45 cases in the smear-negative group showed that 35 cases were diagnosed as pulmonary tuberculosis,and 10 cases were diagnosed as non-tuberculosis infection.The effector T cells in the alveolar lavage fluid of the smear-positive and smear-negative group patients were detected by the tuberculosis infection effect T-SPOT,and the positive rate were analyzed.The alveolar lavage fluid were collected from the patients in the smear-negative group and alveolar lavage fluid were detected by using mycobacterium tuberculosis simultaneous amplification and testing for SAT-TB.The diagnostic value of the effect of alveolar lavage fluid T cell detection were analyzed by comparing results with T-SPOT detection.Results By the T-SPOT test,the positive rate of smear-positive group(97.14%)was higher than that in smear-negative group(75.56%),and the difference was statistically significant(P＜0.05).When the smear-negative group was tested,the positive rate(94.29%)in the smear-negative tuberculosis group by T-SPOT was higher than that in SAT-TB test(77.14%),and the difference was statistically significant(P＜0.05).By T-SPOT test,the sensitivity(94.29%),the positive predictive value(PPV)(97.06%)and the negative predictive value(NPV)(81.82%)were higher than those in SAT-TB(77.14%,96.43%,and 52.94%),and the differences were statistically significant(P＜0.05).The specificity of the two detection methods were both 90.00%.Conclusion In the rapid detection of smear-negative pulmonary tuberculosis,the detection of effector T cells in alveolar lavage fluid has high sensitivity and remarkable application value.
2021 Vol. 28 (26): 216-219 [Abstract] ( 56 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
220 Correlation between expression of Her-2 and Ki-67 in breast cancer tissues and levels of serum CA153,CA125 and CEA in patients with breast cancer
LYU Yan-guan； SUN Xiao-chong； ZHU Ting
Objective To explore the correlation between the expression of human epidermal growth factor receptor 2(Her-2)and proliferating cell nuclear antigen Ki-67(Ki-67)and the levels of serum tumor antigen 153(CA153),serum tumor antigen 125(CA125),carcinoembryonic antigen(CEA)in patient with breast cancer.Methods Eighty patients with breast cancer treated in Huaian Maternal and Child Health Care Hospital from January 2017 to December 2019 were selected as research subjects.Patients were divided into the Her-2(+)group and the Her-2(-)group according to the immunohistochemical method.Automatic chemiluminescence analysis method was adopted in the Her-2(+)group and the Her-2(-)group.The serum levels of CA153,CA125,and CEA and the expression of Ki-67 in cancer tissues were retrospectively analyzed.Results The expression of Ki-67 of patients with breast cancer in the Her-2(+)group was higher than that in the Her-2(-)group,with statistically significant difference(P＜0.05).There were no statistically significant differences in the levels of CA153,CA125 and CEA between the two groups(P＞0.05).The expression rate of Ki-67≤20% was 20%(16/80),and the expression rate of Ki-67＞20% was 80%(64/80).The high expression of Ki-67 was positively correlated with the expression of Her-2 in patients(P＜0.05).Conclusion The serum levels of CA153,CA125 and CEA in patients with breast cancer have nothing to do with the expression of Her-2.However,the high expression of Ki-67 is positively correlated with the expression of Her-2.
2021 Vol. 28 (26): 220-222 [Abstract] ( 51 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
223 Diagnostic value of α-fetoprotein,α-fetoprotein heterogenes and tumor necrosis factor-α in the diagnosis of primary liver cancer
ZHANG Dan-xia；ZHANG Yong-hu； GUI Ruo-hu； WANG Xiao-yang； WU You-xing
Objective To explore the application value of α-fetoprotein(AFP),α-fetoprotein heterogenes(AFP-L3)and tumor necrosis factor-α(TNF-α)detection in the diagnosis of primary liver cancer.Methods Fifty patients with primary liver cancer who were treated in Hengyang Central Hospital from January to December 2019 were selected as the research group,and 50 healthy people who came to Hengyang Central Hospital for physical examination during the same period were selected as the control group.The two groups of personnel were tested for AFP,AFP-L3 and TNF-α.The two groups were compared and analyzed for AFP,AFP-L3 and TNF-α test results,test results of patients with different pathological stages in the study group and the diagnostic power of the combined test.Results The levels of AFP,AFP-L3 and TNF-α of the study group were higher than those of the control group,the differences were statistically significant(P＜0.05).The levels of AFP,AFP-L3 and TNF-α in patients with tumor stage of Ⅲ-Ⅳwere higher than those in patients with tumor stage of Ⅰ-Ⅱ,and the differences were statistically significant(P＜0.05).The levels of AFP,AFP-L3 and TNF-α of patients in the moderately differentiated group and the well-differentiated group were lower than those of the poorly differentiated group,and the differences were statistically significant(P＜0.05).The sensitivity of the combined detection of AFP,AFP-L3 and TNF-α indicators were higher than those of independent detection,and the differences were statistically significant(P＜0.05).Conclusion The combined detection of AFP,AFP-L3 and TNF-α in patients with primary liver cancer can reflect the severity of the patient′s condition,and the detection is highly sensitive,which is beneficial to clinical application and promotion.
2021 Vol. 28 (26): 223-225转229 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
226 Levels changes and correlation analysis of serum ferritin and inflammatory factors in elderly patients with osteoporosis and pathological fracture
ZHONG Jian
Objective To analyze the levels changes and correlation of serum ferritin(FERR)and inflammatory factors in elderly patients with osteoporosis and pathological fracture.Methods A total of 81 patients with osteoporosis and pathological fractures admitted to Hangzhou Yuhang Banger Hospital from September 1,2017 to January 31,2021 were selected as the experimental group,and 30 physical examinations in the same period were selected as the control group.The two groups of bone mineral density(BMD),FERR,serum amyloid A(SAA),hypersensitive C-reactive protein(hs-CRP)and interleukin 6(IL-6),immunoglobulin A(IgA),white blood cell count(WBC),neutrophil percentage(Neu%),lymphocyte percentage(Lym%)levels were compared,and Spearman correlation analysis was also performed.Results The BMD and LYM% in the experimental group were lower than those in the control group,the differences were statistically significant(P＜0.05).FERR,SAA,hs-CRP,IL-6,IgA,Neu% in the experimental group were higher than those in the control group,the differences were statistically significant(P＜0.05).In the experimental group,FERR level was negatively correlated with bone mineral density(r=-0.406, P＜0.05),and positively correlated with SAA,hs-CRP,IL-6,IgA and other inflammatory factors(r=0.331,0.385,0.371,0.288; P＜0.05).Conclusion The serum FERR level of elderly patients with osteoporosis associated with pathological fracture is positively correlated with the levels of inflammatory factors such as SAA,hs-CRP,IL-6 and IgA(P＜0.05),which has certain clinical reference value for the prevention,diagnosis and treatment of this disease.
2021 Vol. 28 (26): 226-229 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 5 )
230 Application of self-made follow-up manual and personalized education in improving self-management of stroke patients
LUO Qiu-lan；OUYANG Liang-mei； ZHAO Li-li；LAN Gui-xiang
Objective To explore the application effect of self-made follow-up manual combined with personalized education in improving self-management of stroke patients.Methods A total of 200 cases of stroke patients in Ganzhou Municipal Hospital from January to December 2019 were selected as the rasearch onjects and divided into the comteol group and the observation group by random number table method,with 100 cases in each group.The control group received traditional follow-up+health education,while the observation group received self-made follow-up manual+personalized health education.The awareness rate of stroke risk factors knowledge,medication compliance,daily life dependence and stroke recurrence rate 6 and 12 months after discharge were compared between the two groups.Results The knowledge rate of stroke risk factors and medication compliance of patients in the observation group were higher than those in the control group,the degree of dependence on daily life was lower than that in the control group,and the recurrence rate of stroke at 6 and 12 months after discharge were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The self-made follow-up manual combined with personalized education has good effect in improving the self-management of stroke patients.
2021 Vol. 28 (26): 230-232 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
233 Application research of standardized patients combined with "microclass+flipped classroom" teaching mode in the practical teaching of Basic Nursing
CHEN Wei
Objective To explore the application effect of standardized patients combined with "micro-class+flipped classroom" teaching mode in the practical teaching of Basic Nursing.Methods From September 2019 to January 2020,46 people from Class 1 of 2018 Nursing College of Huizhou Health Vocational And Technical College were selected as the observation group,and 42 people from Class 2 were selected as the control group.In the practical teaching of Basic Nursing,the observation group adopted the teaching mode of standardized patients combined with "micro-class+flipped classroom".The control group adopted the traditional teaching mode of "theory teaching-teacher teaching-group practice".After the teaching,the comprehensive test scores,teaching model scores and satisfaction with the teaching model of the two groups were compared.Results The overall score of comprehensive examination in the observation group([97.6±1.2]points)was higher than that in the control group([88.5±2.6]points),and the difference was statistically significant(P＜0.001).In the observation group,the scores for facilitating communication ability cultivation([91.6±9.9]points),promoting knowledge understanding and memory([75.1±9.9)points],exercising clinical adaptability([83.5±10.7]points),improving the ability of analyzing and solving problems([79.2±11.4]points),facilitating the mastery of skill operation([86.5±10.2]score)and stimulating learning initiative and developing cooperative consciousness([91.2±10.5]score)were higher than those of the control group([70.2±10.4],[61.0±10.5],[60.4±9.2],[60.5±10.2],[70.6±10.4],[67.1±10.4]points),and the differences were statistically significant(P＜0.05).The satisfaction of the observation group with teaching mode(95.7%)was higher than that of the control group(76.2%),and the difference was statistically significant(P＜0.05).Conclusion The teaching mode of standardized patients combined with "micro-class+flipped classroom" highlights the teaching concept of "student-oriented",which is conducive to the cultivation of thinking,practical and innovative talents,and is worthy of popularization and application in the practical teaching of Basic Nursing.
2021 Vol. 28 (26): 233-236 [Abstract] ( 54 ) HTML (40 KB)  PDF  (0 KB)  ( 9 )
237 Application study of online and offline mode in continuing nursing care of gestational diabetes
LEI Jun ；YAN Yan； CHEN Hai-xia； SHI Xiang-hong ；ZHOU Yan； SONG Wei
Objective To explore the application effect of online and offline models in the continued care of patients with gestational diabetes mellitus(GDM).Methods From January to December 2020,60 cases of GDM patients admitted to the Jiujiang Maternal and Child Health Hospital in Jiangxi Province were selected as the research objects.They were divided into the observation group(30 cases)and the control group(30 cases)by random number table method.The control group used conventional home continuous care,and the observation group used online information platform+home continuous care supported by outpatient consultation.The blood glucose level,mental state and body mass index of the two groups were compared.Results The fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of the observation group after nursing were lower than those of the control group,the differences were statistically significant(P＜0.05).The self-rating anxiety scale(SAS)and depression self-evaluation(SDS)scores of the observation group after nursing were lower than those of the control group,and the differences were statistically significant(P＜0.05).The body mass index of the observation group after nursing was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The online and offline combined model has a good application effect in the continuous care of GDM patients,which can effectively control their blood sugar levels,help relieve negative emotions and improve body mass index.
2021 Vol. 28 (26): 237-239 [Abstract] ( 59 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
240 Application effect of exercise based cardiac rehabilitation nursing in elderly patients with chronic heart failure
XIAO Yan-lan； XIAO Lin； YANG Min
Objective To explore the application effect of exercise-based cardiac rehabilitation nursing in elderly patients with chronic heart failure(CHF).Methods A total of 70 CHF elderly patients hospitalized in the Second Affiliated Hospital of the University of South China from March to July 2020 were selected as the research objects.According to the random number table method,they were divided into the control group(n=35)and the observation group(n=35).The control group received routine nursing,and the observation group added exercise rehabilitation training.The effective rate of nursing,the changes of cardiac function index and exercise ability before and after nursing were compared between the two groups.Results The total effective rate in the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).There were no significant differences in cardiac function and exercise ability between the two groups before nursing(P＞0.05).After nursing,the heart ejection fraction of the observation group was higher than that before nursing and the control group,the difference was statistically significant(P＜0.05);the left ventricular end systolic diameter and end diastolic diameter of the two groups after nursing were lower than those before nursing,and the left ventricular end systolic diameter and end diastolic diameter of the observation group after nursing were lower than those of the control group,the differences were statistically significant(P＜0.05);the six min walking distance of the two groups after nursing were longer than those before nursing,the six min walking distance of the observation group after nursing was longer than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Exercise based cardiac rehabilitation nursing can significantly improve the clinical effect during elderly patients with CHF the patients，cardiac indicators and exercise tolerance have been significantly improved,that plays an important role in reducing the impact of various complications.
2021 Vol. 28 (26): 240-243 [Abstract] ( 59 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
244 Application of nursing intervention based on INS standards in maintenance of peripheral vein indwelling needle in pediatric respiratory department
ZHU Shu-gui； DENG Yu-ying； HUANG Pian-pian
Objective To explore the application effect of nursing intervention based on the Infusion Therapy Standards of Practice(infusion nurses society[INS]standards,compiled by the INS in 2016)in the maintenance of peripheral venous indwelling needles in pediatric respiratory department.Methods A total of 688 children received indwelling peripheral intravenous needles who were admitted to Zhuhai Maternal and Child Health Hospital were selected as the research subjects.They were grouped according to the time of admission: the children admitted from May to August 2019 were set as the control group(n=342),and routine maintenance and care of peripheral vein indwelling needles were performed;the children admitted from September to November 2019 were set as the observation group(n=346),corresponding intervention was provided with the reference to the standards formulated by the INS after summarizing and analyzing the occurrence and causes of catheter blood return,errhysis,dressings coverslipped or loose,non-standardized fixation of indwelling needle,and phlebitis during the maintenance of intravenous indwelling needles.The indwelling time and the incidence of adverse reactions between the two groups were compared.Results The indwelling time of the venous indwelling needle in the observation group was longer than that in the control group,the incidence of blood return,dressings coverslipped or loose,irregular fixation of the indwelling needle,and phlebitis in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of intravenous indwelling needle errhysis between the two groups(P＞0.05).Conclusion The nursing intervention for the maintenance of indwelling needles in children based on INS standards can better reduce the incidence of adverse reactions during the maintenance of indwelling needles in children,increase the safety of indwelling veins,and effectively prolong the indwelling time of indwelling needles.
2021 Vol. 28 (26): 244-246转250 [Abstract] ( 58 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
247
[15]夏云祥，楚云杰，马远，等.中药熏蒸联合穴位按摩在髋部骨折患者术后康复中的应用[J].长春中医药大学学报，2018，34（2）：127-129.
Effect analysis of acupoint massage combined with emotional nursing intervention in lower extremity fracture
[15]夏云祥，楚云杰，马远，等.中药熏蒸联合穴位按摩在髋部骨折患者术后康复中的应用[J].长春中医药大学学报，2018，34（2）：127-129.
Effect analysis of acupoint massage combined with emotional nursing intervention in lower extremity fracture
[J]. 中国当代医药, 2021,28(26): 247-250')" href="#">		 LIU Ying；LI Zheng
Objective To explore the effect of acupoint massage combined with emotional nursing intervention in lower extremity fracture.Methods A total of 110 patients with lower extremity fracture after surgery admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from May 2018 to February 2021 were selected.According to the random digital table method,patients were divided into the control group(55 cases)and the observation group(55 cases).The control group used traditional orthopedic intervention,and the observation group carried out acupoint massage combined with TCM emotional nursing intervention on the basis of the control group.Both groups were treated with intervention for one course(30 d).The self-rating anxiety scale(SAS),self-rating depression scale(SDS),hospital of special surgery knee score(HSS)and barthel index(MBI)scores and the incidence of complications during intervention between two groups were compared.Results There were no significant differences in SAS and SDS scores between the two groups before intervention(P＞0.05);the SAS and SDS scores of the two groups after intervention were lower than those before intervention,the SAS and SDS scores of the observation group after intervention were lower than those of the control group,and the differences were statistically significant(P＜0.05).There were no significant difference in HSS and MBI scores between the two groups before intervention(P＞0.05);the HSS and MBI scores of the two groups after intervention were higher than those before intervention,the scores of HSS and MBI in the observation group were higher than those in the control group after intervention,the differences were statistically significant(P＜0.05).During the intervention,the total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion The application of acupoint massage combined with TCM emotional nursing intervention for patients with lower limb fractures can effectively relieve anxiety and depression,promote the recovery of knee joint function,improve the quality of life,and reduce complications.
2021 Vol. 28 (26): 247-250 [Abstract] ( 61 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
251 Effect of ADL capacity-based training on self-care ability and complications in elderly maintenance hemodialysis patients
ZHANG Lian-he； LI Xiu-mei；ZHOU Qiao-ling
Objective To explore the value of daily life ability(ADL)training intervention in elderly patients with maintenance hemodialysis(MHD).Methods A total of 64 elderly patients with MHD admitted to Affiliated Hospital of Gansu University of Traditional Chinese Medicine from January 2018 to January 2021 were selected,and divided into the control group(32 cases)and the observation group(32 cases)according to random number table method.The control group used routine care,ADL ability training intervention was used in the observation group.The negative emotion(self-rating depression scale[SDS],self-care ability Barther index[BI]),nursing satisfaction and complications were compared between the two groups.Results Before the intervention,the differences in SDS,BI scores of two groups were not statistically significant(P＞0.05).After the intervention,SDS score in the observation group was lower than that in the control group,BI score was higher than that of the control group,the differences were statistically significant(P＜0.05).The nursing total satisfaction of the observation group was higher than that of the control group,the total incidence of complications in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion ADL ability training intervention can reduce depression in elderly patients with MHD,improve their ability to take care of themselves,reduce complications,improve nursing satisfaction.
2021 Vol. 28 (26): 251-254 [Abstract] ( 55 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
255 Application value of MDT nursing intervention in elderly patients undergoing laparoscopic common bile duct incision and stone removal
FU Ying； FU Ting
Objective To explore the application value of multi-disciplinary team(MDT)nursing intervention in elderly patients undergoing laparoscopic common bile duct incision and stone removal.Methods A total of 84 elderly patients undergoing laparoscopic choledochectomy and lithotripsy who were admitted to Yichun People′s Hospital from October 2019 to October 2020 were selected as the research subjects.They were divided into the control group(42 cases)and the observation group(42 cases)by using random number table.Patients in the control group received routine nursing care,and patients in the observation group used MDT nursing intervention.The recovery of gastrointestinal function,pain degree,quality of life,nursing satisfaction and total occurrence of postoperative complications were compared between the two groups.Results The observation group′s postoperative food intake,first anal exhaust,first defecation,and bowel sound recovery time were shorter than those of the control group,the differences were statistically significant(P＜0.05).Before the intervention,the visual analogue scoring(VAS),the quality of life questionnaire(QOL-30)score comparison showed no significant differences(P＞0.05).After the intervention,the VAS score of the observation group was lower than that of the control group,and the QOL-30 score was higher than that of the control group,the differences were statistically significant(P＜0.05).The total nursing satisfaction of the observation group was higher than that of the control group,the total incidence of postoperative complications in the observation group was lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion The application of MDT nursing intervention in elderly patients undergoing laparoscopic common bile duct incision and stone removal can promote the recovery of gastrointestinal function,reduce postoperative complications,improve the quality of life,and increase nursing satisfaction.
2021 Vol. 28 (26): 255-258 [Abstract] ( 47 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
259 Application effect of the guidance of turning over by medical-nursing cooperation in critically ill patients in the ICU
ZHAO Jia-feng
Objective Exploring the application effect of the medical-nursing cooperation guidelines for turning over in critically ill patients in the ICU.Methods From January 1，2019 to June 30,the 213 patients who were treated in Jiaxing Hospital of Traditional Chinese Medicine according to the conventional turn-over method were selected as the control group.From July 1,2019 to December 31,the 219 patients who were treated in Jiaxing Hospital of Traditional Chinese Medicineaccording to the turn-over guidelines established by doctors and nurses were selected as the study group.The incidence of adverse events,incidence of complications,rate of secondary intubation,unplanned stay in ICU,and nursing satisfaction were compared between the two groups.Results The total incidence of adverse events in the study group was lower than that of the control group,the total incidence of complications was lower than that of the control group,the rate of secondary intubation was lower than that of the control group,the unplanned stay in ICU was shorter than that of the control group,and the nursing total satisfaction was higher than that of the control group,the differences were statistically significant(P＜0.05).Conclusion The medical-nursing cooperation guidelines for turning over critically ill patients can reduce complications,adverse events,unplanned extubation,make patients more satisfied.
2021 Vol. 28 (26): 259-261 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
262 Research of traditional Chinese medicine emotional nursing on anesthetic effect and psychological pain of patients undergoing painless gastroscopy
ZHANG Wei； SHI Gui-mei ；WANG Liang
Objective To explore the effect of traditional Chinese medicine(TCM)emotional nursing in patients with painless gastroscopy.Methods A total of 70 patients underwent painless gastroscopy in iujiang Hospital of Traditional Chinese Medicine from October 2018 to October 2020 were selected and divided into the control group and the observation group by random number table method,35 patients in each group.Patients in the control group were given routine intervention,while patients in the observation group were given TCM emotional nursing on this basis.Psychological state including self-rating anxiety scale(SAS),self-rating depression scale(SDS)and psychological pain including the 6-point behavioral rating scale(BRS-6)scores were compared between the two groups before and after examination.Anesthetic effect was statistically compared between the two groups,and patients′satisfaction with nursing was investigated.Results After examination,the scores of SAS was(22.35±3.11),SDS was(23.50±3.14)and BRS-6 was(1.37±0.13)points in the observation group，lower than those in the control group of(28.98±3.15),(29.91±3.28)and(2.20±0.16)points,respectively.The disappearance time of eyelash reflex was(40.53±4.32)s and waking time was(6.02±0.08)min in the observation group，shorter than those of the control group of(55.84±5.21)s and(6.45±0.12)min,respectively.The dosage of propofol was(2.71±0.19)mg/kg in the observation group,less than the control group of(4.59±0.52)mg/kg,the nursing total satisfaction of the observation group was 94.29%,higher than that of the control group accounting for 77.14%,the differences were statistically significant(P＜0.05).Conclusion TCM emotional nursing can improve the negative emotions of patients undergoing painless gastroscopy,relieve the psychological pain of patients,enhance anesthetic effect,and increase patients′ satisfaction.
2021 Vol. 28 (26): 262-264转268 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
265 Effect of visual dispersion nursing on pain and psychological status of children with congenital heart disease in intensive care unit
LIN Yu
Objective Effect of visual dispersion nursing on pain and psychological status of children with congenital heart disease in intensive care unit.Methods 56 children with congenital heart disease admitted in the ICU of Fujian Provincial Hospital from January to December 2020 as the research objects，and divide them into the control group（n=28） and the observation group （n=28） according to random number table method.The control group adopts the ordinary nursing model，and the observation group adopts the visual dispersive nursing based on ordinary nursing,the family nursing l satisfaction，visual analogue scale （VAS） and medical fear scale score （CMFS） scale were compared between two groups.Results The nursing total satisfaction of the family members of the observation group was higher than that of the control group after taking nursing measures，and the difference was statistically significant （P＜0.05）.Before the nursing intervention，there was no significant difference in the VAS scale scores between the two groups of children （P＞0.05）;The VAS score of the observation group after nursing intervention was lower than that of the control group，the medical fear scale scores of the observation group were lower than the control group，the differences were statistically significant （P＜0.05）.The drug usage rate of the observation group was lower than that of the control group，the length of stay in ICU was shorter than that of the control group，and the comfort score was higher than that of the control group，the differences were statistically significant （P＜0.05）.Conclusion The application of visual dispersion nursing in ICU congenital heart disease nursing has exact effect，which is conducive to improving the quality of nursing.
2021 Vol. 28 (26): 265-268 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
269 Clinical value of continuous nursing based on WeChat in children with asthma
LIN Rong ；YE Li-qing
Objective To observe the clinical effect of WeChat based continuous nursing in children with asthma.Methods A total of 116 asthmatic children admitted to the First Hospital of Nanping City from April 2018 to February 2020 were selected as the study subjects and divided into the test group(n=58)and the control group(n=58)using random number table method,while the control group received usual care,and the test group applied continuing care on the basis of control group two groups regarding medication adherence,asthma perception,inhalation technique scores differences in asthma control rates,lung function measures,and quality of life(AQLQ)scores among patients with asthma.were compared.Results There were no significant differences in medication compliance,asthma awareness,inhalation technique,lung function index,AQLQ score between the two groups before nursing(P＞0.05);the test groups medication compliance and asthma awareness after nursing,the scores of inhalation technique and asthma control rate were higher than those of the control group,and the differences were statistically significant(P＜0.05);the lung function index levels and AQLQ quality of life scores of the test group after nursing were higher than those of the control group,and the differences were statistically significant.Significance(P＜0.05).Conclusion The application of WeChat based continuity care to asthmatic children is able to play a desirable role and deserves to be widely promoted in the clinic.
2021 Vol. 28 (26): 269-272 [Abstract] ( 51 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
273 Effect of Roy′s adaptive nursing model on patients with Crosne′s disease
LI Xiao-fang
Objective To approach effect of Roy′s adaptive nursing model on patients with Crosne′s disease.Methods The 60 cases crohn patients in Fujian Medical University Affiliated the First Hospital from February 2018 to February 2020 were selected as research objects,they were divided into the control group and the detection group by random number table method,30 cases in each group.The control group was used routine nursing,the detection group was used Roy adaptation nursing mode.The depress score,anxious score,mental toughness score,coping style score of two group patients before intervention and after intervention were detected,the complications of two group patients were detected.Results The depress score,anxious score,mental toughness score,coping style score of two group patients before intervention were compared,the difference were no statistical significance(P＞0.05);after intervention,the depress score,anxious score of two group were lower than before intervention,mental toughness score,coping style score were higher than before intervention,the depress score,anxious score of detection group were lower than those of the control group,mental toughness score,coping style score were higher than those of the control group,the total complications of detection group was lower than that of the control group,the differences were statistical significance(P＜0.05).Conclusion The application of crohn patients by Roy adaptation nursing mode,which could improve depress,anxious,increase mental toughness and coping style,decrease complications.
2021 Vol. 28 (26): 273-276 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
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