乳腺癌患者组织Her-2与Ki-67表达和血清CA153、CA125、CEA水平的相关性

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Abstract Objective To explore the correlation between the expression of human epidermal growth factor receptor 2(Her-2)and proliferating cell nuclear antigen Ki-67(Ki-67)and the levels of serum tumor antigen 153(CA153),serum tumor antigen 125(CA125),carcinoembryonic antigen(CEA)in patient with breast cancer.Methods Eighty patients with breast cancer treated in Huaian Maternal and Child Health Care Hospital from January 2017 to December 2019 were selected as research subjects.Patients were divided into the Her-2(+)group and the Her-2(-)group according to the immunohistochemical method.Automatic chemiluminescence analysis method was adopted in the Her-2(+)group and the Her-2(-)group.The serum levels of CA153,CA125,and CEA and the expression of Ki-67 in cancer tissues were retrospectively analyzed.Results The expression of Ki-67 of patients with breast cancer in the Her-2(+)group was higher than that in the Her-2(-)group,with statistically significant difference(P＜0.05).There were no statistically significant differences in the levels of CA153,CA125 and CEA between the two groups(P＞0.05).The expression rate of Ki-67≤20% was 20%(16/80),and the expression rate of Ki-67＞20% was 80%(64/80).The high expression of Ki-67 was positively correlated with the expression of Her-2 in patients(P＜0.05).Conclusion The serum levels of CA153,CA125 and CEA in patients with breast cancer have nothing to do with the expression of Her-2.However,the high expression of Ki-67 is positively correlated with the expression of Her-2.

Key words： Breast cancer Human epidermal growth factor receptor 2 Proliferating cell nuclear antigen Ki-67 Tumor markers

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	Articles by authors
	LYU Yan-guan
	SUN Xiao-chong
	ZHU Ting

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LYU Yan-guan,SUN Xiao-chong,ZHU Ting. Correlation between expression of Her-2 and Ki-67 in breast cancer tissues and levels of serum CA153,CA125 and CEA in patients with breast cancer[J]. 中国当代医药, 2021, 28(26): 220-222.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I26/220

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