两种不同助孕方案在前次早卵泡期长方案助孕失败患者中的应用效果比较

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Abstract Objective To explore the application effect of two different pregnancy aid regimens in patients with previous pregnancy aid failure with long-term early follicular phase.Methods From January 2019 to December 2020,a total of 122 patients admitted to Ganzhou Maternal and Child Health Hospital,who had failed the previous in-vitro fertilization-embryo transfer assisted pregnancy and received the second assisted pregnancy were selected as the research subjects.According to the coin toss method,the patients were divided into group A(52 cases)and group B(70 cases).The patients in group A were treated with the long-term early follicular phase program,and the patients in group B were treated with the antagonist program.The clinical indicators and the results of ovulation induction were compared between the two groups.Results There was no statistical significance in the number of eggs obtained and the number of embryos transferred between the two groups(P＞0.05).The total dose of gonadotropin(Gn)in group B was less than that in group A,and Gn days were shorter than that in group A.The number of 2 prokaryotic embryos,cleavage number and transferable embryos in group B were more than that in group A,the differences were statistically significant(P＜0.05).On Gn initiation day,there was no statistical significance in FSH between two groups(P＞0.05),the levels of estrogen(E2)and luteinizing hormone(LH)in group B were lower than those in group A,the differences were statistically significant(P＜0.05).On the day of human chorionic gonadotropin(HCG)injection,there was no significant difference in endometrial thickness between the two groups(P＞0.05),the levels of E2 and progesterone in group B were higher than those in group A,the differences were statistically significant(P＜0.05).There was no statistical significance in the optimal embryo rate,transplantation rate,blastocyst formation rate and early abortion rate between the two groups(P＞0.05).The cumulative pregnancy rate in group B was higher than that in group A,and the incidence of moderate to severe ovarian hyperstimulation syndrome(OHSS)was lower than that in group A,the differences were statistically significant(P＜0.05).Conclusion For those who have failed the early follicular phase long program,the antagonist program for re-fertilization can effectively increase the cumulative pregnancy rate and reduce the incidence of moderate to severe OHSS,and the effect is significant.

Key words： Fertility program Previous early follicular phase Fertility failure Pregnancy rate

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	HUANG Yun
	SHUAI Mei
	YUE Lin-lin

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HUANG Yun,SHUAI Mei,YUE Lin-lin. Comparison of the effect of two different pregnancy aid regimens in patients with previous pregnancy aid failure with long-term early follicular phase[J]. 中国当代医药, 2021, 28(26): 144-147.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I26/144

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