盐酸吡格列酮对2型糖尿病患者血管内皮功能的影响研究

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Abstract Objective To explore the effect of Pioglitazone Hydrochloride on vascular endothelial function in patients with type 2 diabetes.Methods A total of 80 patients diagnosed with type 2 diabetes in the Department of Endocrinology,Affiliated Hospital of Jiujiang University from January to December 2019 were selected as the research objects,and divided into the Pioglitazone group and the placebo group according to the random number table method,with 40 cases in each group.The placebo group received placebo treatment,and the Pioglitazone group received Pioglitazone Hydrochloride treatment.The blood glucose control effect,vascular endothelial function,and the asymmetric dimethylarginine(ADMA)and dimethylarginine-dimethylarginine in the peripheral serum,the level of methylamine hydrolase(DDAH),mental state scores,body mass index,and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of endothelin(ET-1)and ADMA in the Pioglitazone group were lower than those in the placebo group,the differences were statistically significant(P＜0.05);nitric oxide(NO),blood flow-mediated vasodilation(Flow-mediated dilation,FMD)and DDAH levels in the Pioglitazone group after treatment were higher than those the placebo group,the differences were statistically significant(P＜0.05).After treatment,the fasting blood glucose content,two hours postprandial blood glucose content,glycosylated hemoglobin content,mental state scores,and body mass index of the Pioglitazone group were lower than those of the placebo group,the differences were statistically significant(P＜0.05).Conclusion Pioglitazone Hydrochloride is effective in the treatment of type 2 diabetes with good safety.More popularization and application can help improve the treatment effect and reduce the occurrence of adverse reactions.

Key words： Pioglitazone Hydrochloride Type 2 diabetes Vascular endothelial function Asymmetric dimethylarginine Dimethylarginine-dimethylamine hydrolase

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	YU Jian-xin
	ZHOU Li-lan
	XU Ren-wei

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YU Jian-xin,ZHOU Li-lan,XU Ren-wei. Study on the effect of Pioglitazone Hydrochloride on vascular endothelial function in patients with type 2 diabetes[J]. 中国当代医药, 2021, 28(26): 73-76.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I26/73

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