|
|
|
| Effect of magnesium sulfate on neonatal hypoxic-ischemic encephalopathy |
| YANG Yi-hua |
| Department of Pediatrics,Fukuang General Hospital,Liaoning Health Industry Group,Liaoning Province,Fushun 113008,China |
|
|
|
|
Abstract Objective To investigate the effect of magnesium sulfate in the treatment of neonatal hypoxic-ischemic encephalopathy.Methods A total of 64 asphyxia neonates born in the Department of Obstetrics and Gynecology of Fukuang General Hospital from February 2018 to August 2019 were selected as the research subjects.They were randomly divided into the treatment group(n=32)and the control group(n=32).The control group was given conventional treatment.The treatment group was additionally given magnesium sulfate treatment on the basis of the control group.The clinical efficacy,clinical symptoms improvement time,Mg2+ level,pH level of arterial blood gas and human S100-B protein(S100-B)level,the pediatric growth and development(Gesell developmental scale score),and the occurrence of adverse reactions of the two groups were observed.Results The total effectiveness rate of the treatment group was 93.75%,higher than that of 71.88% of the control group,with statistical significance(P＜0.05).The improvement time of muscular tension,primitive reflex and state of consciousness in the treatment group was shorter than that of the control group,with statistical significance(P＜0.05).The comparison of arterial blood gas pH,Mg2+ level,and S100-B level before treatment between the two groups of children was not statistically significant(P＞0.05).The arterial blood gas pH and Mg2+ levels in the treatment group at 2 and 6 d after treatment were higher than those before treatment and the control group,and the level of S100-B was lower than that before treatment and the control group,with statistical significance(P＜0.05).The arterial blood gas pH and Mg2+ of the control group at 6 d after treatment were higher than those before treatment,and the level of S100-B was lower than that before treatment,with statistical significances(P＜0.05).After 8 months of follow-up,the Gesell score of the treatment group was higher than that of the control group,with statistical significance(P＜0.05).One case of hypotension occurred in the treatment group,and the control group had no adverse reactions,total incidence of adverse reactions was compared between the two groups,the difference was not statistically significant(P＞0.05).Conclusion Magnesium sulfate can effectively improve the clinical symptoms of neonates with hypoxic-ischemic encephalopathy,shorten the course of the disease,promote the recovery of nerve function in high safety.
|
|
|
|
|
|
| [1] |
杨长坤.产科危险因素与新生儿缺氧缺血性脑病相关性研究[J].健康之友，2020，16（20）：8.
|
| [2] |
黄文卿，张巍，刘巍巍.新生儿缺氧缺血性脑病相关药物治疗的研究进展[J].医学综述，2020，26（22）：4457-4461.
|
| [3] |
宋琳，郭津，等.远隔缺血后处理对新生儿缺氧缺血性脑病的神经保护作用[J].中国儿童保健杂志，2020，28（11）：1219-1222.
|
| [4] |
杨璐颖，王灵芝，陈棉.新生儿缺血缺氧性脑病D-二聚体和脂蛋白a 水平及其与病情严重程度和脑损伤的关系[J].重庆医学，2020，49（12）：1969-1972.
|
| [5] |
代红，范小康.高胆红素血症新生儿血清NPY、S100B 蛋白、B/A 比值与胆红素脑损伤的关系[J].海南医学，2020，31（23）：3050-3053.
|
| [6] |
刘聪慧，高伟，等.国内新生儿缺氧缺血性脑病产科危险因素的系统评价[J].中国妇幼保健，2019，34（9）：2169-2173.
|
| [7] |
刘敬.新生儿缺氧缺血性脑病的临床管理——英国《新生儿缺氧缺血性脑病临床管理指南》介绍[J].实用儿科临床杂志，2012，27（2）：150-152.
|
| [8] |
张诗，何慧静，万国斌.200 名晚期早产儿的盖塞尔婴幼儿智能评估量表的测试分析[J].诊断学理论与实践，2017，16（2）：217-220.
|
| [9] |
于波.神经节苷脂联合灯盏花素治疗HIE 的应用研究[J].中国现代医生，2019，57（10）：56-58.
|
| [10] |
李俊英，李杨方.新生儿缺氧缺血性脑病的氧化应激机制与最新治疗进展[J].中国当代医药，2019，26（1）：27-30.
|
| [11] |
黄小玲，林跃清，周冰新，等.血清S100B 蛋白在新生儿缺氧缺血性脑病中的应用[J].中国当代医药，2020，27（30）：82-85.
|
| [12] |
王晓宇，王成秀，陈聪.胎儿炎症反应综合征新生儿脐血NSE、S100B 水平对脑损伤早期筛查的预测价值[J].检验医学与临床，2020，17（16）：2284-2288.
|
| [13] |
苟知贤，鲁利群.褪黑素治疗新生儿缺氧缺血性脑损伤的研究进展[J].成都医学院学报，2018，13（6）：759-762.
|
| [14] |
杨璐颖，王灵芝，陈棉.新生儿缺血缺氧性脑病D-二聚体和脂蛋白a 水平及其与病情严重程度和脑损伤的关系[J].重庆医学，2020，49（12）：1969-1972.
|
| [15] |
张玉娇，周杏.血清电解质、CKBB 及血乳酸水平与新生儿缺氧缺血性脑病严重程度的相关性分析[J].中南医学科学杂志，2020，48（2）：179-182.
|
|
|
|
