BMI-1和MMP-3基因多态性与汉族群体乳腺癌易感性的关联分析

Abstract
Figure/Table
References (19)
Related Citation (15)

Download: PDF (0 KB) HTML (40 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective To study the association between three single nucleotide polymorphisms of B-cell-specific moloney leukemia virus insection site 1(BMI-1)and matrix metalloproteinase 3(MMP-3)genes and breast cancer susceptibility in Han nationality.Methods Using the case-control study method,from January 2014 to July 2018,a total of 524 Han women with breast cancer treated in the Second Affiliated Hospital of Qiqihar Medical College,the Third Affiliated Hospital of Qiqihar Medical College,Qiqihar Jianhua Hospital,and Daqing Oilfield General Hospital were selected as the case group,and 518 healthy people receiving healthy checkup in the same period were selected as the control group.PCR-LDR technology was used to detect and type the genetic polymorphisms of BMI-1 gene rs1042059,rs201024480 locus and MMP-3 gene rs3025058 locus,and the risk value(OR)and 95% confidence interval(CI)were used to express the risk of breast cancer.Results There were statistically significant differences in allele frequency and genotype distribution of MMP-3 gene rs3025058 locus between the case group and the control group(P=0.008).There was no statistically significant difference in gene polymorphism of BMI-1 gene rs1042059 locus and rs201024480 locus between the case group and the control group(P>0.05).After adjusting for confounding factors,the risk of breast cancer in the population carrying allele 5A and genotype 5A5A was increased by 1.51 and 1.48 times respectively(OR=1.51,95%CI: 1.17-1.94; P=0.001 and OR=1.48,95%CI: 1.16-1.91; P=0.001).Conclusion The polymorphism of MMP-3 gene rs3025058 is associated with the risk of breast cancer,and can be used as a candidate locus for breast cancer

susceptibility genes.

Key words： Breast cancer B-cell-specific moloney leukemia virus insection site 1 Matrix metalloproteinase 3 Gene polymorphism Susceptibility

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Ming-long
	WANG Xiu-hua
	LYU Ying
	LI Peng-hui
	LIU Dan
	MEI Qing-bu
	LIU Wan-quan
	ZHENG Li-hong

Cite this article:

ZHANG Ming-long,WANG Xiu-hua,LYU Ying, et al. Association analysis of BMI-1 and MMP-3 gene polymorphisms with breast cancer susceptibility in Han nationality[J]. 中国当代医药, 2021, 28(26): 14-17.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I26/14

[1]	Guo X，Lin W，Bao J，et al.A Comprehensive cis -eQTL Analysis Revealed Target Genes in Breast Cancer Susceptibility Loci Identified in Genome-wide Association Studies[J].Am J Hum Genet，2018，102（5）：890-903.
[2]	M JR，S V.BMI1 and PTEN are key determinants of breast cancer therapy：A plausible therapeutic target in breast cancer[J].Gene，2018，678：302-311.
[3]	Sun P，Mu Y，Zhang S.A novel NF-κB/MMP-3 signal pathway involves in the aggressivity of glioma promoted by Bmi-1[J].Tumour Biol，2014，35（12）：12721-12727.
[4]	Balkhi S，Mashayekhi F，Salehzadeh A，et al.Matrix metalloproteinase （MMP）-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer[J].Mol Biol Rep，2020，47（12）：9637-9644.
[5]	Zhu S，Zhao D，Yan L，et al.BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1[J].Nat Commun，2018，9（1）：500.
[6]	Yan Y，Wang Y，Zhao P，et al.BMI-1 Promotes Self-Renewal of Radio- and Temozolomide（TMZ）-Resistant Breast Cancer Cells[J].Reprod Sci，2017，24（12）：1620-1629.
[7]	Zhang J，Sarge KD.Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitinproteasome system[J].FEBS Lett，2009，583：960-964.
[8]	Jiang L，Wu J，Yang Y，et al.Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway[J].BMC Cancer，2012，12：406.
[9]	Wang D，Lou X，Jiang XM，et al.Quercetin protects against inflammation，MMP2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi 1 expression[J].Mol Med Rep，2018，18（1）：610-616.
[10]	Li X，Yang Z，Song W，et al.Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase （MMP）2，MMP -9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway[J].Int J Oncol，2013，43（3）：793-802.
[11]	Sotiriou C，Pusztai L.Gene-expression signatures in breast cancer[J].N Engl J Med，2009，360（8）：790-800.
[12]	Gonzalez-Villasana V，Fuentes-Mattei E，Ivan C，et al.Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer[J].Clin Cancer Res，2015，21：2127-2137.
[13]	Suhaimi SA，Chan SC，Rosli R.Matrix Metallopeptidase 3 Polymorphisms：Emerging genetic Markers in Human Breast Cancer Metastasis[J].J Breast Cancer，2020，23（1）：1-9.
[14]	Hsiao CL，Liu LC，Shih TC，et al.The Association of Matrix Metalloproteinase-1 Promoter Polymorphisms with Breast Cancer[J].In Vivo，2018，32（3）：487-491.
[15]	Oliveira VA，Chagas DC，Amorim JR，et al.Association between matrix metalloproteinase-9 gene polymorphism and breast cancer in Brazilian women[J].Clinics，2020，75：e1762.
[16]	Dofara SG，Chang SL，Diorio C.Gene Polymorphisms and Circulating Levels of MMP-2 and MMP-9：A Review of Their Role in Breast Cancer Risk[J].Anticancer Res，2020，40（7）：3619-3631.
[17]	Lei H，Hemminki K，Altieri A，et al.Promoter polymorphisms in matrix metalloproteinases and their inhibitors：few associations with breast cancer susceptibility and progression[J].Breast Cancer Res Treat，2007，103（1）：61-69.
[18]	Abd Elmaogoud Ragab Ibrahim F，Essam Elfeky S，Haroun M，et al.Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk：A case-control study[J].Mol Clin Oncol，2020，13（1）：54-62.
[19]	Ghilardi G，Biondi ML，Caputo M，et al.A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility[J].Clin Cancer Res，2002，8（12）：3820-3823.