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2021 Vol. 28, No. 25
Published: 2021-09-08
 
 
4 A meta-analysis of risk factors for cognitive impairment in hypertensive patients
ZOU Lian-yu； ZHENG Li-wei；FAN Wei-ying；CHEN Shun； LIU Wei-hua
Objective To explore the risk factors of cognitive impairment(CI)in hypertensive patients by meta-analysis.Methods The literatures related to risk factors of CI in hypertensive patients were retrieved from PubMed,Embase,Web of Science,Cochrane Library,China National Knowledge Infrastructure,VIP database,Wanfang database,Chinese Biomedical Literature database(CBM).The retrieval time limit was from the establishment of the database to May 2020.Two researchers independently screened the literatures,extracted the data,evaluated the literature quality and metaanalysis was performed using RevMan 5.3 software.Results A total of 25 studies were included.Meta-analysis results showed that advanced age(OR=1.11,95%CI[1.07,1.16], P<0.000 01),low educational level(OR=4.44,95%CI[2.21,8.93], P<0.0001),high systolic blood pressure(OR=1.37,95%CI[1.18,1.59], P<0.0001),high microalbumin creatinine ratio(OR=1.18,95%CI[1.08,1.28], P=0.0003),hyperhomocysteinemia(OR=1.65,95%CI[1.27,2.14], P=0.0002),history of cerebrovascular disease(OR=2.26,95%CI[1.58,3.24], P<0.000 01)were risk factors for patients with CI in hypertension(P<0.05).High insulin resistance index was not a risk factor for patients with CI in hypertension(OR=1.57,95%CI[0.92,2.67], P=0.10).Conclusion The current evidence shows that old age,low education level,high systolic blood pressure,high microalbumin creatinine ratio,hyperhomocysteinemia and history of cerebrovascular disease are risk factors for CI in hypertensive patients,but the conclusion still needs more high quality research further validation.
2021 Vol. 28 (25): 4-8 [Abstract] ( 58 ) HTML (49 KB)  PDF  (0 KB)  ( 5 )
9 Clinical study of Wenyang Yiqi Huoxue Decoction combined with acupoint application on bradycardia of yang deficiency and blood stasis type
CHEN Guang-jin； LI Mei-hong ；ZOU Pei-yuan；YANG Qing-bang； ZHUANG Dong-ming
Objective To explore the clinical effect of Wenyang Yiqi Huoxue Decoction combined with acupoint application on bradycardia of yang deficiency and blood stasis type.Methods A total of 60 patients diagnosed with bradyarrhythmia of yang-deficiency and blood stasis type in the Department of Cardiology,Yangjiang Hospital of Traditional Chinese Medicine from January to December 2020 were selected as the research objects,and they were divided into the treatment group and the control group by random number table method,with 30 cases in each group.Patients in the control group were given oral Salbutamol Sulphate Tablets,2 mg/times,3 times/d.Patients in the treatment group were given Wenyang Yiqi Huoxue Decoction,1 dose per day,combined with acupoint application therapy,1 patch per day for a total of 4 weeks.The scores of traditional Chinese medicine(TCM)syndromes,total effective rate of TCM syndromes,resting heart rate,24-hour dynamic electrocardiogram average heart rate,minimum heart rate,total heart rate and total incidence of adverse reactions were compared between the two groups of patients before and after treatment.Results After treatment,the TCM syndrome score of the treatment group was lower than that before treatment,and the difference was statistically significant(P<0.05).There was no statistically significant difference in TCM syndrome score in the control group before and after treatment(P>0.05).The total effective rate of TCM syndromes of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the resting heart rate,24-hour dynamic electrocardiogram average heart rate,the minimum heart rate and the total heart rate in the two groups were higher than those before treatment,and the differences were statistically significant(P<0.05).After treatment,there were no statistically significant differences in the resting heart rate,24-hour dynamic electrocardiogram average heart rate,the minimum heart rate and the total heart rate between the two groups(P>0.05).The total incidence of adverse reactions in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Wenyang Yiqi Huoxue Decoction combined with acupoint application can increase the heart rate of patients with bradyarrhythmia of yang deficiency and blood stasis type,improve the symptoms of TCM,and reduce the occurrence of adverse reactions.
2021 Vol. 28 (25): 9-12转17 [Abstract] ( 49 ) HTML (43 KB)  PDF  (0 KB)  ( 8 )
13 Meta-analysis of comparison between hydromorphone and sufentanil in postoperative intravenous controlled analgesia
FAN Xing； LIU Hui ；PAN Bing-bing
Objective To evaluate the patient controlled intravenous analgesia effect between hydromorphone and sufentanil.Methods PubMed,Cochrane Library,CBM,CNKI,Wanfang Database,and VIP Database(by October 30,2020)were searched for citations comparing hydromorphone and sufentanil for the patient controlled intravenous analgesia.After screening the citations,extracting data,and evaluating the quality,Revman 5.2 software was used for statistical data analysis.The outcomes included pain score,sedation score,the incidence of nausea and vomiting,itching,and respiratory depression during postoperative.Results A total of 14 studies involving 1161 patients were included.The results showed that the postoperative analgesic effect of hydromorphone was better than that of sufentanil in the elderly,with statistically significant difference（MD=-1.13,95%CI=-1.76- -0.50, P=0.0005）,and there was no difference in the younger（MD=0.19,95%CI=-0.10-0.48, P=0.20）.Compared with sufentanil,PCIA with hydromorphone showed no significant difference in the incidence of postoperative sedation,nausea and vomiting,and itching（MD=-0.16,95%CI=-0.47-0.15, P=0.31, OR=0.83,95%CI=0.53-1.30, P=0.42; OR=0.95,95%CI=0.45-2.04, P=0.9）,but lowered the incidence of respiratory depression,with statistically significant difference（OR=0.28,95%CI=0.11-0.72, P=0.008）.Conclusion Compared with sufentanil,PCIA with hydromorphone has a better analgesic effect in the elderly,and reduce the incidence of respiratory depression.
2021 Vol. 28 (25): 13-17 [Abstract] ( 47 ) HTML (41 KB)  PDF  (0 KB)  ( 6 )
18 Effect of depression and anxiety on cognitive function of patients with liver cancer after operation
LIU Zhao-guo；DENG Hui-zhen；HE Xiao-yan
Objective To explore the relationship between depression,anxiety and cognitive dysfunction in patients with liver cancer after operation.Methods A total of 120 patients with liver cancer who underwent inpatient operations in the Department of Hepatobiliary Surgery in the Fourth Affiliated Hospital of Guangxi Medical University from January 2016 to January 2019 were selected as the research subjects.Patients were examined before and after operation using a set of cognitive neuropsychological tests(including line connect test,symbol test,Hopkins vocabulary learningrevised version,simple visual memory test-revised version,Stroop color word test,continuous performance test),selfrating depression scale(SDS),and self-rating anxiety scale(SAS)in order to understand the cognitive function,depression and anxiety.The cognitive function of patients with depression,anxiety and patients without depression and anxiety after operation were compared,and the effect of depression and anxiety on postoperative cognitive function was explored.Results Of the 120 patients with liver cancer,6 were shed at the time of evaluation,so a total of 114 patients completed the survey.The detection rates of depression and anxiety were 40.35% and 31.58% respectively.After surgery,patients with depression and anxiety had longer time of the line connect test than patients without depression and anxiety,and had lower scores of symbol test,Hopkins vocabulary learning-revised version,simple visual memory test-revised version,color word test,continuous performance test than patients without depression and anxiety,the differences were statistically significant(P<0.05).The depression and anxiety of patients after operation were positively correlated with the time of the line connect test,and were negatively correlated with the result of symbol coding test,Hopkins vocabulary learning test,simple visual memory test,color word test,continuous performance test(P<0.05).Conclusion Patients with depression and anxiety after liver cancer surgery have overall cognitive decline.It is speculated that depression and anxiety may further aggravate cognitive dysfunction after liver cancer surgery.
2021 Vol. 28 (25): 18-22 [Abstract] ( 50 ) HTML (43 KB)  PDF  (0 KB)  ( 7 )
23 Determination of testosterone in deer blood by solid phase extraction coupled with liquid chromatography-mass spectrometry
HU Chun-lan； CHEN Yuan-yuan； WANG Chun-min；REN Gui-qi
Objective To establish a method for the determination of testosterone in deer blood by solid phase extraction coupled with liquid chromatography-mass spectrometry for the quality control of deer blood.Methods Firstly,the samples were pretreated,and then the testosterone content in deer blood was determined by using fixed quantum ion(109.06)under the conditions of liquid chromatography and mass spectrometry.Build sample preparation: acetonitrile precipitation deer blood protein,ethyl acetate extracted first testosterone,the solution to the activation of SAX(Maximum loading volume was 500 mg,volume was 3 mL)solid phase extraction column,the liquid obtained by nitrogen blow to nearly dry,N-hexane extraction,three times to add to the activated Florisil(maximum loading volume was 500 mg,volume was 3 mL)solid phase extraction column,abandon the filtrate,ethyl acetate,N-hexane(60∶40,V/V)elution pillars,nitrogen blow dry.The solution was dissolved in 50% methanol and passed through 0.22 μm microporous filtration membrane.High performance liquid chromatography condition:shim-Pack XR-ODS column(2.0 mm×75 mm,2.2 μm).The mobile phase consisted of methanol-0.1% formic acid-water and gradient elution.Column temperature was 40℃.Flow rate was 0.3 mL/min.Sample size was 20 μL.The mass spectrum condition:de-clustering voltage(DP)was 60.0 V,collision energy(CE)was 10.0 eV.Results In the linear range of 1.5165×10-4 to 3.033×10-1 μg/mL,the R of the fixed quantum ion 109.06 was 0.9995.The average recovery was 66.62%(n=6), RSD was 3.44%.The content of testosterone in four batches of deer blood was 3.30×10-4 to 3.48×10-4 μg/mL,with RSD <3%.Conclusion The method for the determination of testosterone in deer blood by solid phase extraction coupled with liquid chromatography-mass spectrometry was established.The linear range and recovery rate of solid phase extraction coupled with liquid chromatography-mass spectrometry are in line with the requirements of laws and regulations,and could provide reference for the quality evaluation of deer blood.
2021 Vol. 28 (25): 23-26 [Abstract] ( 51 ) HTML (41 KB)  PDF  (0 KB)  ( 6 )
27
Effect of Rosuvastatin combined with Ezetimibe in patients with myocardial infarction and its influence on the level of inflammatory factors
Effect of Rosuvastatin combined with Ezetimibe in patients with myocardial infarction and its influence on the level of inflammatory factors
[J]. 中国当代医药, 2021,28(25): 27-31')" href="#">		 WANG Xiang-jie； XU Qing-zong； ZHANG Xue； JIA Bo-han
Objective To explore the effect of Rosuvastatin combined with Ezetimibe in patients with myocardial infarction and its influence on the level of inflammatory factors.Methods A total of 94 patients with myocardial infarction admitted to the Third People′s Hospital of Dalian from January 2019 to January 2020 were selected as the research subjects and divided into the study group(47 cases)and the control group(47 cases)according to the random number table method.The control group was treated with Rosuvastatin,and the study group was treated with Rosuvastatin combined with Ezetimibe.The inflammatory factor levels(tumor necrosis factor -α[TNF-α],hypersensitive C-reactive protein[hs-CRP]and interleukin 6[IL-6]),treatment effect and blood lipid levels(total cholesterol[TC],triylglycerol[TG],low density lipoprotein cholesterol[LDL-C]),the total incidence of adverse reactions and myocardial enzyme levels(lactate dehydrogenase[LDH],creatine kinase[CK],creatinine kinase isoenzyme[CK-MB])of two groups were compared.Results The levels of TNF-α,hs-CRP and IL-6 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before the treatment,there were no statistically significant differences in the levels of TC,TG,LDL-C between the two groups(P>0.05).After the treatment,the levels of TC,TG,LDL-C in the study group were lower than those in the control group,with statistically significant difference(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before the treatment,there were no statistically significant differences in the levels of LDH,CK and CK-MB between the two groups(P>0.05).After the treatment,the levels of LDH,CK and CK-MB in the study group were lower than those in the control group,with statistically significant difference(P<0.05).Conclusion Patients with myocardial infarction were treated with Rosuvastatin combined with Ezetimibe,with a certain therapeutic effect,could effectively improve the clinical symptoms in patients with myocardial infarction,at the same time,also can effectively reduce the blood lipid levels in patients with myocardial infarction,inhibiting inflammatory reaction,reduce the adverse reaction condition,high safety,it′s worth popularizing further application in clinic.
2021 Vol. 28 (25): 27-31 [Abstract] ( 54 ) HTML (41 KB)  PDF  (0 KB)  ( 6 )
32 Research progress on the pharmacological effect of Curculigo orchioides
YIN Jia； LIU Hui-hui；QIANG Ming-min；GAO Yu-qin
Curculigo orchioides is a perennial herbaceous plant in the amaryllidaceae family,which is rich in many important biologically active substances such as polysaccharides,saponins,phenols,phenol glycosides,terpenes and so on，which have been used medicinally in many countries,and it is also included in the Pharmacopoeia of the People′s Republic of China(hereinafter referred to as "Chinese Pharmacopoeia").The pharmacology of traditional Chinese medicine suggests that Curculigo orchioides has the effect of promoting blood and reducing swelling,invigorating the kidney and yang,strengthening muscles and bones,and nourishing essence and blood,it is used for clinical symptoms such as deficiency of kidney yang,cold pain in the lumbar and spine,cold deficiency and uterine bleeding,vaginal discharge,sore swelling and pain,kidney empty internal injury,muscle pain and so on.Modern pharmacological studies have confirmed that Curculigo orchioides has anti-inflammatory,anti-oxidant,anti-osteoporosis,anti-depressant,immune regulation,and protection of vascular endothelial cells,it is of great significance for the treatment of cardiovascular,osteoporosis,diabetes,rheumatism and other related diseases.In this paper,the modern pharmacological effect,toxic and side effect of Curculigo orchioides are reviewed,in order to provide a research basis for the clinical application of Curculigo orchioides.
2021 Vol. 28 (25): 32-36 [Abstract] ( 53 ) HTML (52 KB)  PDF  (0 KB)  ( 8 )
37 Medicinal value and application prospect of Radix Serratulae Chinensis
WANG Song
Radix Serratulae Chinensis as local learning products since a long time,which had the characteristics of clinical widely used,medicinal materials demand volume,and vast space.As a substitute for Cohosh,which had a lot of problems of be replaced,quality standard backward and the research content was limited.Research of Radix Serratulae Chinensis focused on the quality analysis,content determination and extraction process, etc.Research of which in clinical pharmacology,effective mechanism,efficacy of attending,formulation development was limited.The research status was inconsistent with which drug demand and clinical prescription.The author through the literature,summarized research progress on source of medica,replaced usage,active ingredients,quality standard,clinical pharmacology of Radix Serratulae Chinensis.The author put forward the prospect of thinking about Radix Serratulae Chinensis from the base source,resource development,the pharmacological efficacy,quality standard,formulation development to speed up the development of Radix Serratulae Chinensis.
2021 Vol. 28 (25): 37-40 [Abstract] ( 53 ) HTML (41 KB)  PDF  (0 KB)  ( 7 )
41 Clinical research progress of growth hormone secretagogues
MENG Guang-peng； LI Si-jun；MA Hao-yu；XU Miao；LIU Shuang；GAO Jian；FU Xiao-ping；ZHANG Lan
Growth hormone secretagogue(GHS)is a generic term to describe compounds that increase growth hormone release.GHSs include agonists of the growth hormone secretagogue receptor,and agonists of the growth hormone-releasing hormone receptor.Several GHSs have been developed with a view to treating or diagnosing of growth hormone deficiency,which causes growth retardation,gastrointestinal dysfunction,and altered body composition,and in-depth studies on their mechanisms and pharmacology have been conducted.This review will focus on the history,pharmacological findings,and randomized clinical trial data of GHS.Furthermore,the author will highlight the publicly disclosed clinical trials regarding GHS.
2021 Vol. 28 (25): 41-47转55 [Abstract] ( 59 ) HTML (58 KB)  PDF  (0 KB)  ( 9 )
48 Application of autologous platelet-rich plasma combined with transverse tibia lateral bone transport in refractory diabetic foot wounds
DU Yong-wei； LIU Zhen； MO Jian-wen； XU Fang-tian；TANG Wen；YUAN Ge-huan；YAO Fei
Objective To explore the application of autologous platelet-rich plasma(PRP)combined with tibia lateral bone transport in the refractory diabetic foot(DF)wound.Methods A total of 45 patients with DF admitted to the First Affiliated Hospital of Gannan Medical University from January to December 2020,and divided into group A,group B and group C according to the random number table method,with 15 cases in the each group.Group A was treated with PRP,group B was treated with tibia lateral bone transport,and group C was treated with PRP combined with tibia lateral bone transport.The total effective rate,the levels of serum growth factors(epidermal growth factor[EGF],vascular endothelial growth factor[VEGF],basic fibroblast growth factor[bFGF])before and after treatment,and the occurrence of adverse reactions were compared among the three groups.Results After the treatment,the total effective rate was compared among the three groups,with statistically significant difference(P<0.05).The total effective rate of group C was higher than that of the group A and group B,with statistically significant difference(P<0.05).After the treatment,the level of EGF,VEGF and bFGF in the three groups were higher than those before the treatment in the group,and the level of EGF,VEGF and bFGF in group C was higher than those in the group A and group B,the level of EGF,VEGF and bFGF in group B was higher than those in the group A,the differences were statistically significant(P<0.05).There was no statistically significant difference in the occurrence of adverse reactions compared among the three groups(P>0.05).Conclusion The application of PRP combined with tibia lateral bone transport in the treatment of refractory DF wounds could effectively increase response rate of treatment,enhance the activities of tissue regeneration and repair,it′s with highly safety.
2021 Vol. 28 (25): 48-51 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
52 Study of trans-theoretical model combined with motivational interviewing on rehabilitation self-efficacy of patients with hemiplegia
XU Shu-hua； LI Min ；TANG Xiao-dong

Objective To study and analyze the effects of trans-theoretical model(TTM)combined with motivational interviewing(MI)intervention on rehabilitation self-efficacy of patients with hemiplegia.Methods A total of 86 patients with hemiplegia admitted to the Third Affiliated Hospital of Gannan Medical University from May 2019 to June 2020 were selected as the study subjects,and they were divided into the control group(43 cases)and the experimental group(43 cases)according to the random number table method.The control group received with routine nursing intervention method,and the experimental group received with TTM combined with MI intervention method.The self-efficacy level(general self-efficacy scale[GSES]),ability of daily living(barthel index[BI]),quality of life(generic quality of life inventory-74[GQOL-74])and body movement function(Fugl-Meyer assessment[FMA])were compared between the two groups.Results Before intervention,there were no statistically significant differences in the scores of GSES,BI,GQOL-74 between the two groups(P>0.05).After one month of intervention,the scores of GSES,BI,GQOL-74 in experimental group were higher than those in the control group,with statistically significant differences(P<0.05).After one month of intervention,the FMA grade of the experimental group was better than that of the control group,with statistically significant difference(P<0.05).Conclusion TTM combined with MI could improve the body movement function and ability of daily living and enhance the self-efficacy and quality of life of patients with hemiplegia,with high clinical application value.
2021 Vol. 28 (25): 52-55 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
56 Effect of quadruple therapy combined with Kangfuxin Liquid in patients with Helicobacter pylori-related ulcer
YI Zhen
Objective To explore the effect of quadruple therapy combined with Kangfuxin Liquid in patients with Helicobacter pylori-related ulcer.Methods A total of 56 patients with gastric and duodenal bulb ulcers admitted to the Shangrao Municipal Hospital from March 2018 to March 2020 as the research objects,and divided into the control group and the observation group according to the random number table method,with 28 cases in each group.The control group was treated with quadruple therapy,and the observation group as treated with quadruple therapy combined with Kangfuxin Liquid.The total effective rate, Helicobacter pylori eradication rate and recurrence rate,and total incidence of adverse reactions were compared between the two groups.Results After the treatment,the total effective rate of the observation group was 92.86%,which was higher than 67.87% of the control group,and the differences were statistically significant(P<0.05).The Helicobacter pylori clearance rate of the observation group was 96.43%,which was higher than 71.42% of the control group,and the differences were statistically significant(P<0.05).The recurernce rate of the observation group was 7.14%,which was lower than 28.57% of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions of the observation group was 7.14%,lower than 28.57% of the control group,and the differences were statistically significant(P<0.05).Conclusion In patients with Helicobacter pylori associated ulcer disease,quadruple therapy combined with Kangfuxin Liquid could significantly improve the clinical efficacy,improve Helicobacter pylori,reduce the recurrence rate of Helicobacter pylori,and effectively reduce the incidence of adverse reactions,and the clinical application value is significant.
2021 Vol. 28 (25): 56-58转62 [Abstract] ( 112 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
59 Application of improved sheath delivery technology in PICC catheter placement under ultrasound B guidance in patients with thrombocytopenia
JIANG Ze-xian； WU Chun-ling； FANG Jing； SHEN Jia-kun； MA Hui
Objective To explore the application effect of improved sheath delivery technology in peripherally inserted central catheter(PICC)placement under ultrasound B guidance in patients with thrombocytopenia.Methods From June 2019 to June 2020,a total of 81 patients with thrombocytopenia who underwent PICC catheterization under the guidance of B-ultrasound in the Department of Hematology of Shangrao People′s Hospital were selected as research subjects.According to the random number table,they were divided into a traditional group with 41 cases and a modified group with 40 cases.The modified group used a modified sheath delivery method to expand the skin,and the traditional group used a traditional scalpel to expand the skin.Catheterization conditions of the two groups including the success rate of one-time catheterization,completion time of delivery of the sheath,blood loss immediately after the expansion of the skin and delivery of the sheath,the score of pain immediately after catheterization and the post-intubation conditions were compared.In addition,including the number of dressing changes within 96 hours of catheter placement and the occurrence of complications.Results There was no statistically significant difference in the success rate of one-time catheterization between the two groups(P>0.05).The delivery time of the modified group was shorter than that of the traditional group,the difference was statistically significant(P<0.05).The blood loss immediately after the expansion and delivery of the sheath was less than that of the traditional group,the difference was statistically significant(P<0.05).The pain score was lower than that of the traditional group,and the differences were statistically significant(P<0.05).The number of dressing changes within 96 hours of catheter placement in the modified group was less than that of the traditional group,and the incidence of bleeding,exudation,and puncture point infections were lower than that of the traditional group,the difference was statistically significant(P<0.05).Conclusion In patients with thrombocytopenia,the successful rate of one-time catheterization for PICC under the guidance of B-ultrasound is equivalent to that of traditional scalpel expansion.The improved sheath delivery technology can shorten the delivery completion time,reduce the number of dressing changes after catheter placement and the blood loss immediately after expanding the sheath and deliver the sheath,and alleviate pain immediately after catheter placement in higher safety.
2021 Vol. 28 (25): 59-62 [Abstract] ( 45 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
63 Clinical effect of Salmeterol and Fluticasone combined with Montelukast Sodium in the treatment of acute attack of moderate to severe bronchial asthma
SONG Qing-jun
Objective To investigate the clinical effect of Salmeterol and Fluticasone combined with Montelukast Sodium in the treatment of acute attack of moderate to severe bronchial asthma.Methods A total of 135 patients with acute attack of moderate to severe bronchial asthma in Changqing District People′s Hospital of Ji′nan City from January 2019 to December 2020 were selected as the research objects.According to the random number table method,the patients were divided into the control group(68 cases)and the treatment group(67 cases).The patients of the control group were given Salmeterol and Fluticasone aerosol inhalation,while the patients of the treatment group were given Montelukast Sodium on the basis of the control group.The clinical efficacy,pulmonary function indexes before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The clinical efficacy of the treatment group was better than that of the control group,the difference was statistically significant(P＜0.05).There was no statistical significance in the level of forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)in the first second before treatment(P＞0.05).The levels of FEV1 and PEF in the patients of the two groups after treatment were higher than those before treatment,the differences were statistically significant(P＜0.05).The levels of FEV1 and PEF in the treatment group were higher than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the patients in the two groups(P＞0.05).Conclusion The clinical effect of Salmeterol Fluticasone combined with Montelukast Sodium in the treatment of acute attack of moderate to severe bronchial asthma is significant,which can significantly improve the lung function of patients,and does not increase adverse reactions,it is worthy of clinical promotion and application.
2021 Vol. 28 (25): 63-65 [Abstract] ( 59 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
66 Effect of fiberoptic bronchoscopy sputum suction combined with alveolar lavage in the treatment of severe pulmonary infection
ZHANG Nan
Objective To explore the effect of fiberoptic bronchoscope suction combined with alveolar lavage(FBBL)in the treatment of severe pulmonary infections.Methods A total of 78 patients with severe pulmonary infection admitted to the Iron Coal General Hospital of Liaoning Health Industry Group from June 2018 to December 2020 were selected as the research samples,they were divided into observation group(39 cases)and control group(39 cases)by random lottery method.The control group performed conventional treatment methods,on this basis,the observation group used FBBL therapy to compare the arterial blood gas indicators,hospitalization status and complication rate of the two groups.Results After treatment,the partial pressure of carbon dioxide in pulse blood(PaCO2)of the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05);after treatment,the blood oxygen saturation(SpO2)and pondus hydrogenii(pH)of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05);the observation group′s symptom improvement time,mechanical ventilation time,antibacterial drug use time,and ICU hospital stay were shorter than those of the control group,the differences were statistically significant(P<0.05);during the treatment period,the total incidence of complicatiens in the observation group compared with the control group,the difference was not statistically significant(P>0.05).Conclusion As an adjuvant treatment for patients with severe pulmonary infection,FBBL therapy can improve arterial blood gas indicators,improve hospitalization,and will not increase the risk of complications,and patient safety and effectiveness can be guaranteed.
2021 Vol. 28 (25): 66-68转72 [Abstract] ( 47 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
69 Effect of rational use of blood components on the treatment and safety of blood transfusion in patients with upper gastrointestinal bleeding
JIAO Dong-mei
Objective To observe the effect of rational use of blood components on the treatment and safety of blood transfusion in patients with upper gastrointestinal bleeding.Methods A total of 54 patients with upper gastrointestinal bleeding admitted to Baicheng Hospital from October 2018 to October 2020 were selected as the research objects,and they were divided into experimental group(27 cases)and control group(27 cases)using a simple randomization method.The experimental group adopted a planned blood transfusion protocol developed by the department of blood transfusion,and the control group applied for single blood transfusion treatment.The blood routine and coagulation index test results,the success rate of first hemostasis,rebleeding rate,and hospital stay were compared between the two groups.Results One hour before treatment,Comparison of blood routine and coagulation index test results between two group of patients,the differencce was not statistically significant(P>0.05).Three hours after treatment,the levels of hemoglobin(Hb),hematocrit(HCT)and platelet count(PLT)in the test group were higher than those in the control group,and the differences were statistically significant(P<0.05).Three hours after treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)of the test group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the first hemostatic success rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the rebleeding rate of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the hospital stay of the experimental group was shorter than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The rational use of blood components has a positive impact on the blood transfusion treatment of patients with upper gastrointestinal bleeding.It can improve blood routine and coagulation indicators,increase the success rate of first hemostasis,reduce the rate of rebleeding,shorten the length of hospitalization,and improve safety.
2021 Vol. 28 (25): 69-72 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
73 Effect of Baduanjin exercise on cardiac function and quality of life in patients with heart failure after myocardial infarction
ZHOU Yu-xuan； LI San-jun； XIA Wu-mei； LIU Yuan-yuan ；CAO Gan-qiang； WU Ke-qin
Objective To study the effect of Baduanjin exercise on cardiac function and quality of life in patients with heart failure after myocardial infarction.Methods A total of 100 patients with cardiac function grade Ⅱor Ⅲafter myocardial infarction who were treated in the Honggutan Hospital,Jiangxi Provincial People′s Hospital were selected as subjects from September 2019 to September 2020,and the patients were divided into conventional group and combined group according to the random number table method,with 50 cases in each group.Conventional group was given conventional treatment and health education,and combined group was additionally given Baduanjin exercise on the basis of conventional group.The 6 min walking distance,left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and quality of life of the two groups were observed.Results There was no statistical significance in the 6 min walking distance between the two groups before intervention(P>0.05).The 6 min walking test distance after intervention in both groups was longer than those before intervention,and the 6 min walking test distance after intervention in the combined group was longer than that in the conventional group,with statistical significances(P<0.05).Before intervention,there were no significant differences in LVESD,LVEDD and LVEF levels between the two groups(P>0.05).After intervention,the LVESD and LVEDD levels in the two groups were lower than those before intervention,and the LVESD and LVEDD levels in the combined group were lower than those in the conventional group,and the LVEF level in the combined group was higher than that in the conventional group,with statistical significances(P<0.05).The quality of life scores of the two groups after intervention were lower than those before intervention,and the quality of life scores of the combined group after intervention were lower than those of the routine group,with statistical significances(P<0.05).Conclusion Baduanjin exercise can effectively enhance the quality of life,and improve the cardiac function and clinical symptoms of patients with heart failure after myocardial infarction.
2021 Vol. 28 (25): 73-75转79 [Abstract] ( 61 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
76 Clinical effect of Tolvaptan in treatment of chronic heart failure with hypochloremia
YAO Zhang-lu；DONG Bin
Objective To explore the clinical effect of Tolvaptan in the treatment of chronic heart failure(CHF)with hypochloremia.Methods A total of 60 patients with CHF combined with hypochloremia treated in Heping Hospital Affiliated to Changzhi Medical College from September 2018 to June 2019 were retrospectively selected as research subjects.They were divided into the control group(n=30)and the observation group(n=30)according to the treatment method.Loop diuretic was given to the control group,and Tolvaptan was given to the observation group.The treatment time was one week.The serum chloride,serum sodium,serum potassium,urea nitrogen,serum creatinine,serum hydrogen carbonate(HCO3-),serum albumin,N-terminal pro brain natriuretic peptide(NT-proBNP)before and after treatment in the two groups were compared.The clinical symptom and the rehospitalization rate of cardiovascular disease in half a year after discharge in the two groups were also compared.Results The significant efficiency in the observation group after treatment was higher than that in the control group,with statistically significant difference(P＜0.05).The levels of urea nitrogen,serum creatinine and NT-proBNP in the observation group after treatment were lower than those in the control group,and the serum chloride level in the observation group after treatment was higher than that in the control group,with statistically significant differences(P＜0.05).There were no statistically significant differences in the levels of serum albumin,HCO3-,serum sodium(P＞0.05).There was no statistically significant difference in the rehospitalization rate of cardiovascular disease 6 months of treatment between the two groups(P＞0.05).Conclusion The use of Tolvaptan in patients with CHF and hypochloremia can improve hypochloremia,heart function and renal function in the short term.
2021 Vol. 28 (25): 76-79 [Abstract] ( 57 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
80 Application of Ticagrelor combined with percutaneous coronary intervention in patients with coronary heart disease complicated with atrial fibrillation
CHEN Tian-hai； LIU Kai-dong； ZENG Hai-long
Objective To explore the application of Ticagrelor combined with percutaneous coronary intervention(PCI)in patients with coronary heart disease complicated with atrial fibrillation.Methods Seventy patients with coronary heart disease complicated with atrial fibrillation admitted to Chancheng District Central Hospital of Foshan City from January 2019 to June 2020 were selected as the research objects.According to the random number table method,they were divided into an observation group and a control group,with 35 cases in each group.Both groups were treated with PCI surgery.The control group was treated with Clopidogrel Bisulfate,and the observation group was treated with Ticagrelor.The course of treatment for both groups was one month.The changes of serum index levels,platelet levels and atrial fibrillation episodes before and after treatment were compared between the two groups.Results Before treatment,there were no significant differences in serum indexes levels between the two groups(P>0.05).The levels of hypersensitivity C-reactive protein(hs-CRP),creatine kinase isoenzyme(CK-MB),myoglobin and B-type brain natriuretic peptide(BNP)after treatment in the two group were lower than those before treatment,with statistically significant differences(P<0.05).After treatment,the levels of hs-CRP,CK-MB,myoglobin and BNP in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).There were no significant differences in the levels of maximum platelet aggregation rate(MPA)or platelet response index(PRI)between the two groups before treatment(P>0.05).The MPA levels of the two groups after treatment were lower than those before treatment,with statistically significant differences(P<0.05).The PRI level of the observation group after treatment was higher than that before treatment,with statistically significant difference(P<0.05).After treatment,MPA level in the observation group was lower than that in the control group,and PRI level was higher than that in the control group,with statistically significant differences(P<0.05).After six months of treatment,the observation group had fewer episodes of atrial fibrillation than the control group,the duration of episodes was shorter than that of the control group,and the ST-segment depression during the episode was lower than that of the control group,with statistically significant differences(P<0.05).Conclusion Ticagrelor combined with PCI in the treatment of coronary heart disease complicated with atrial fibrillation can effectively improve the patients′ serum levels,and has a significant anticoagulant effect,which helps to reduce the formation of thrombosis.
2021 Vol. 28 (25): 80-83 [Abstract] ( 55 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
84 Red blood cell distribution width and platelet average volume level changes in patients with chronic heart failure and their correlation with plasma N-terminal probrain natriuretic peptide
CHEN Zhao-rong
Objective To analyze the changes of mean platelet volume(MPV)and red blood cell distribution width(RDW)levels in chronic heart failure,and to explore its relationship with plasma N-terminal pro-brain natriuretic peptide(NT-proBNP).Methods A total of 78 patients with chronic heart failure who were treated in the Department of Internal Medicine of Fanchang District People′s Hospital of Wuhu City from February 2018 to December 2020 were selected as the research objects.According to the New York Heart Association(NYHA)cardiac function classification,the patients were divided into grade Ⅰ/Ⅱ(43 cases)and grade Ⅲ/Ⅳ(35 cases).During the same period,78 healthy subjects were selected as the healthy control group.The MPV,RDW and plasma NT-proBNP detection results of patients after admission were collected,and the MPV,RDW and plasma NT-proBNP levels of the three groups of patients were compared,and their correlation was analyzed.Results RDW,MPV levels and plasma NT-proBNP in chronic heart failure patients were higher than those in healthy control group,and the differences were statistically significant(P<0.05).The levels of RDW,MPV and plasma NT-proBNP in grade Ⅲ/Ⅳwere higher than those in grade Ⅰ/Ⅱ,and the differences were statistically significant(P<0.05).The level of MPV in chronic heart failure patients was positively correlated with plasma NT-proBNP(r=0.223, P=0.048);RDW level was positively correlated with plasma NT-proBNP(r=0.544, P=0.001).Conclusion RDW and MPV have important value in the early diagnosis and evaluation of chronic heart failure.
2021 Vol. 28 (25): 84-86转90 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
87 Effect and safety of different doses of Rosuvastatin Calcium Tablets in the treatment of coronary atherosclerosis
WANG Ting
Objective To investigate the efficacy and safety of different doses of Rosuvastatin Calcium Tablets in the treatment of coronary atherosclerosis(CA).Methods A total of 86 CA patients admitted to Zoucheng People′s Hospital from July 2018 to July 2020 were selected as the research objects,and were divided into the control group(43 cases)and the observation group(43 cases)according to the random number table method.Both groups were treated with Rosuvastatin,the control group was orally administered 10 mg/d,and the observation group was orally administered 20 mg/d.Both continued medication for 3 months.The blood lipid levels,changes in plaque,the degree of lumen stenosis,and the safety of medication were compared between the two groups.Results There was no significant difference in blood lipid levels between the two groups before treatment(P>0.05);After treatment,triacylglycerol(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)were lower than before treatment,and high-density lipoprotein cholesterol(HDL-C)was higher than before treatment,the differences were statistically significant(P＜0.05).There were no statistically significant differences of plaque changes and the degree of lumen stenosis between the two groups before treatment(P>0.05).The maximum area of the plaque cross section and the degree of lumen stenosis after treatment were less than before treatment,and the differences were statistically significant(P＜0.05).The largest cross-sectional area of the plaque and the degree of lumen stenosis in the observation group after treatment were smaller than those in the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in total adverse reactions between the two groups(P>0.05).Conclusion High-dose Rosuvastatin has a better lipid-lowering effect in the treatment of CA,which is beneficial to reduce plaque and reduce coronary stenosis without increasing the risk of adverse reactions.
2021 Vol. 28 (25): 87-90 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
91 Application research on CTA three -dimensional visualization assisted cerebral aneurysm intervention
YE Shi-yang； YOU Tao； LIU Xian-bo

Objective To explore the application value of computerized tomography angiography(CTA)three-dimensional visualization assisted cerebral aneurysm intervention.Methods A total of 74 patients with cerebral aneurysm who were admitted to the Pingxiang People′s Hospital from November 2018 to June 2020 were selected as the research subjects.They were divided into an observation group of 37 cases and a control group of 37 cases according to the alternate grouping method.Both groups received intracranial aneurysm intervention.The control group was assisted by three-dimensional digital subtraction angiography(3D-DSA),and the observation group was assisted by CTA three-dimensional visualization.The operation time,radiation dose and Glasgow outcome scale(GOS)score at 3 months after the operation were compared between the two groups,and the complications and recurrence of the two groups were compared.Results There was no statistically significant difference in the operation time,radiation dose or GOS score of the two groups of patients after 3 months(P>0.05).The incidence of thrombus,aneurysm rupture and postoperative aneurysm recurrence rate were compared between the two groups,and the differences were not statistically significant(P>0.05).The incidence of postoperative puncture point bleeding in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with cranial 3D-DSA assisted cerebral aneurysm intervention,the use of CTA three-dimensional visualization assisted treatment can greatly reduce the incidence of postoperative puncture point bleeding,and the operation time,radiation dose and prognosis are equivalent,without increasing intraoperative thrombosis,the incidence of aneurysm rupture or postoperative aneurysm recurrence rate.
2021 Vol. 28 (25): 91-93 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
94 Application comparison of Agomelatine and Duloxetine in the treatment of patients with first-episode depression
SUN Yan；LIN Dong-mei
Objective To compare the application effect of Agomelatin and Duloxetine in the treatment of first-episode depression.Methods A total of 98 patients with first-episode depression treated in the Department of Psychology of the Fourth People′s Hospital of Yingkou City from November 2018 to November 2019 were selected as the research objects.According to the random number table method,they were divided into group A and group B,with 49 cases in each group.group B was treated with oral Duloxetine,and group A was treated with Agomelatin.Hamilton depression scale(HAMD)was used to evaluate the improvement of depression degree of the two groups before and after treatment.The drug treatment effect of the two groups was evaluated according to the score reduction rate of HAMD after treatment,and the occurrence of adverse drug reactions in the two groups was recorded and analyzed.Results There was no significant difference in HAMD scores between the two groups before treatment(P＞0.05).After treatment,the HAMD scores of the two groups were lower than those before treatment,the differences were statistically significant(P＜0.05).The HAMD score of patients in group A was lower than that in group B,the difference was statistically significant(P＜0.05).The total effective rate of group A was 93.88%,which was higher than 79.59% of group B,the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in group A and group B were 14.29% and 18.37% respectively,and there was no significant difference between the two groups(P＞0.05).Conclusion In the treatment of first-episode depression patients,Agomelatin and Duloxetine have better control effect on depressive symptoms,and the adverse reactions of drugs are less,but in contrast,the efficacy of Agomelatin is more significant.
2021 Vol. 28 (25): 94-96 [Abstract] ( 71 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
97 Influence and safety analysis of modified electroconvulsive therapy on memory function in childhood and adolescent schizophrenia
QU Zhi-jun
Objective To explore the influence and safety of modified electroconvulsive therapy(MECT)on memory function in childhood and adolescent schizophrenia.Methods A total of 76 cases of children and adolescents with schizophrenia in Jiangxi Provincial Mental Hospital from January 2019 to December 2020 were selected as the study objects,and they were divided into the observation group and the control group according to random number table method,38 cases in each group.The control group was given conventional antipsychotic drugs,the observation group was treated with MECT on the basis of the control group.Both groups were treated for 4 weeks.and observed for 1 month after treatment.The clinical efficacy,Wechsler memory scale(WMS)score before and after treatment and the incidence of adverse reactions during treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was 90.00%,which was higher than 66.00% of the control group,the difference was statistically significant(P＜0.05).There were no significant differences in recognition,association,picture and back scores between the two groups(P＞0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion MECT in the treatment of childhood and adolescent schizophrenia can significantly improve the total effective rate,has little effect on memory function of patients,has less adverse drug reactions,and has good safety.
2021 Vol. 28 (25): 97-99 [Abstract] ( 56 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
100 Comparison of the application effect of modified keyhole approach and conventional bone flap approach in microvascular decompression of trigeminal neuralgia
LUO Jie； ZHOU Fan； HUANG Yun-feng； YUAN Jin-gang； CHEN Feng； LI Fan
Objective To compare the application effect of modified keyhole approach and conventional bone flap approach in microvascular decompression(MVD)of trigeminal neuralgia.Methods The medical records of 57 patients with trigeminal neuralgia who treated with MVD in the Department of Neurosurgery of Central Hospital of Huanggang City from February 2017 to June 2019 were retrospectively analyzed.They were divided into the conventional bone flap approach group(30 cases)and the modified keyhole approach group(27 cases)according to different surgical methods.The conventional bone flap approach group was treated with MVD through the conventional bone flap approach,and the modified keyhole approach group was treated with MVD through the modified keyhole approach.Clinical efficacy between the two groups was compared.Follow-up was performed for 12 months after surgery,and the incidence of complications such as intracranial hematoma,cranial nerve palsy,subcutaneous effusion,intracranial infection,cerebrospinal fluid leakage,dizziness/hearing loss of the two groups were recorded in detail.Results The total effective rate of the modified keyhole approach group(88.89%)was higher than that of the conventional bone flap approach group(66.67%),and there was a statistical significance(P＜0.05).The total incidence of complications such as intracranial hematoma,cranial nerve palsy,subcutaneous effusion,intracranial infection,cerebrospinal fluid leakage,vertigo/hearing loss of the modified keyhole approach group(14.81%)was lower than that of the conventional bone flap approach group(36.67%),and there was a statistical significance(P＜0.05).Conclusion The therapeutic effect of modified keyhole approach in MVD of trigeminal neuralgia is superior to the conventional bone flap approach,and the incidence of postoperative complications of modified keyhole approach is significantly lower than that of conventional bone flap approach.
2021 Vol. 28 (25): 100-102转106 [Abstract] ( 37 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
103 Influence of motivational interview on patients with schizophrenia
ZHANG Zong-shun； XU Jing ；CAO Bao-rui ；ZHOU Zhong-huan； LI Qing-mei
Objective To explore the influence of motivational interview(MI)on patients with schizophrenia(SZ).Methods Ninety-eight patients with SZ treated in Zaozhuang Mental Health Center from June 2018 to June 2020 were selected as research subjects,and were divided into the control group(n=49)and the experimental group(n=49)by the random number table method.The control group was given routine intervention,and the experimental group was given MI on the basis of the control group.The self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score and compliance before and after intervention in the two groups were compared.Results Before intervention,there were no statistically significant differences in the SAS and SDS scores in the two groups(P＞0.05).Before intervention,there was no statistically significant difference in the compliance rate in the two groups(P＞0.05).After intervention,the compliance rates in the two groups were higher than those before intervention,the compliance rate in the experimental group was higher than that in the control group,with statistically significant differences(P<0.05).Conclusion MI can effectively improve the mental state and treatment compliance of patients with SZ,which is worthy of clinical application.
2021 Vol. 28 (25): 103-106 [Abstract] ( 53 ) HTML (38 KB)  PDF  (0 KB)  ( 10 )
107 Clinical value of Aripiprazole combined with low-dose Clozapine in the treatment of schizophrenia
ZHAO Hong
Objective To explore the clinical value of Aripiprazole combined with low-dose Clozapine in the treatment of schizophrenia.Methods A total of 76 patients with schizophrenia admitted to Huizhou NO.2 Hospital from May 2019 to May 2020 were selected as the research objects,and divided into the control group(38 cases)and the observation group(38 cases)according to the random number table method.The control group received with low-dose Clozapine tablets,and the observation group received with Aripiprazole tablets combined with low-dose Clozapine tablets.The clinical symptom control excellent and good rate,brief psychiatric rating scale(BPRS)score,and treatment emergent symptom scale(TESS)score were compared between the two groups.Results After 2 months of treatment,the clinical symptom control rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After 2 months of treatment,the observation group′s BPRS score and TESS score were lower than those of the control group,with statistically significant differences(P<0.05).Conclusion Aripiprazole combined with low-dose Clozapine has a better curative effect in the treatment of schizophrenia,could more effectively promote the resolution of symptoms,and the safety of clinical medication is better.
2021 Vol. 28 (25): 107-109 [Abstract] ( 59 ) HTML (29 KB)  PDF  (0 KB)  ( 7 )
110 Application of self-made ureteral calculi occluder in percutaneous nephrolithotomy
WU Shi-ping； ZHOU Hang ；XIE Ming ；JIAN Yue-huang
Objective To explore the application value of self-made ureteral calculi occluder in percutaneous nephrolithotomy(PCNL).Methods Fifty-four patients with ureteral calculi who were treated with PCNL in the Third People′s Hospital of Pingxiang City from July 2017 to March 2020 were selected as the research subjects.They were divided into self-made group(27 cases)and conventional group(27 cases)by the random number table method.Routine PCNL treatment was performed in the conventional group,and PCNL treatment was performed under self-made ureteral calculi occluder in the self-made group.Surgery-related indicators and the occurrence of postoperative complications were compared in the two groups.Results The intraoperative blood loss and stone escape rate of the selfmade group were lower than those of the conventional group,the operation time and postoperative hospital stay were shorter than those of the conventional group,and the first-stage stone clearance rate was higher than that of the conventional group,the differences were statisticcally significant(P<0.05).There was no statistically significant difference in the incidence of postoperative complications(P>0.05).Conclusion The use of self-made ureteral calculi occluder during PCNL can reduce the stone escape rate,increase the rate of one-stage stone clearance,shorten the postoperative recovery without increasing the occurrence of complications,which is worthy of clinical promotion.
2021 Vol. 28 (25): 110-112转116 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
113 Impact comparision of three kinds of surgical treatment for varicocele on male sexual function
WAN Bin； ZHANG Zhuo； DENG Xin-xi
Objective To explore and analyze the impact comparision of three surgical treatments for varicocele on male sexual function.Methods A total of 140 patients with varicocele admitted to the First People′s Hospital of Jiujiang City from August 2013 to June 2019 were retrospectively selected as the research objects.They were divided into open operation group(37 cases),laparoscopic operation group(70 cases)and microscopic varicocele ligation group(33 cases)according to different surgical methods.The open operation group was treated with open retroperitoneal high ligation of internal spermatic vein,the laparoscopic operation group was treated with laparoscopic high ligation of spermatic vein,and the microscopic operation group was treated with microscopic ligation of spermatic vein.The international index of erectile function 5(IIEF-5)score,the incidence of postoperative complications and the changes of peripheral blood hormone levels were compared.Results The IIEF-5 score of microsurgery group was higher than that of open operation group and laparoscopic operation group,the difference was statistically significant(P<0.05).The total incidence of postoperative adverse reactions of microsurgery group was lower than that of open operation group and laparoscopic operation group,the difference was statistically significant(P<0.05).The peripheral blood hormone prolactin,follicle stimulating hormone and luteinizing hormone of microsurgery group were significantly lower than those of open operation group and laparoscopic operation group,the differences were statistically significant(P<0.05).Conclusion microscopic varicocele ligation for patients with varicocele has significant effect,high safety advantages,it is worthy of application.
2021 Vol. 28 (25): 113-116 [Abstract] ( 41 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
117 Transvaginal electrical stimulation combined with hip muscle exercise in the treatment of stress incontinence in women and its effect on urodynamics and pelvic floor muscle strength
ZHANG Bo； HU Xiao-qi ；ZHANG Meng； JIANG Xing-jin； WAN Gang
Objective To investigate the effect of transvaginal electrical stimulation combined with hip muscle exercise on stress incontinence in women and its effect on urodynamics and pelvic floor muscle strength.Methods A total of 110 female patients with stress urinary incontinence admitted to Dalian Friendship Hospital from June 2019 to December 2020 were selected as the research objects,and they were divided into the experimental group(n=55)and the control group(n=55)according to the random number table method.The control group was given hip muscle exercise,and the experimental group was given hip muscle exercise+transvaginal electrical stimulation.The urodynamics,pelvic floor muscle tension,degree of urinary incontinence,quality of sexual life were compared in the two groups.Results The maximum detrusor pressure(Pdetmax),maximum urethral closure pressure(MUCP),abdominal pressure leak point pressure(ALPP)and maximum urinary flow rate(Qmax)of the experimental group after treatment were higher than those of the control group,the differences were statistically significant(P<0.05).The vaginal systolic pressure and vaginal resting pressure of the experimental group after treatment were higher than those of the control group,and the duration of vaginal contraction was longer than that of the control group,the differences were statistically significant(P<0.05).After treatment,the score of the international consultation on incontinence questionnaire short-form(ICIQ-SF)in the experimental group was lower than that in the control group,and the score of pelvic organ prolapse-urlnary incontinence sexual life questionnaire-13(PISQ-31)in the experimental group was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The treatment of transvaginal electrical stimulation combined with hip muscle exercise can effectively improve the contractility of pelvic floor muscles,improve the urodynamics,alleviate the symptoms of incontinence and improve the quality of sexual life of women with stress urinary incontinence.
2021 Vol. 28 (25): 117-120 [Abstract] ( 40 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
121 Clinical effect of laparoscopic radical prostatectomy combined with neoadjuvant hormonal therapy for T3N0M0 prostate cancer
JIANG Qi-qi；YE Lie-fu； WU Xiang； LIU Zhi-hua
Objective To explore the clinical effect of laparoscopic radical prostatectomy combined with neoadjuvant hormonal therapy(NHT)for T3N0M0 prostate cancer.Methods The clinical data of 72 patients with T3N0M0 stage prostate adenocarcinoma admitted to Urology of Fujian Provincial Hospital and Fujian Provincial Jinshan Hospital from January 2010 to July 2019 were retrospectively analyzed.They were divided into the experimental group(38 cases)and the control group(34 cases)according to whether NHT was used.The experimental group were treated by laparoscopic radical prostatectomy combined with NHT.The control group were treated by laparoscopic radical prostatectomy.The operation time,intraoperative blood loss,serum prostate specific antige(PSA)level,postoperative incision margin positive,rectal injury,urinary incontinence,anastomotic leakage and erectile dysfunction were compared between the two groups.Results There was no significant difference in the operation time between the two groups(P>0.05).There was no significant difference in the amount of bleeding between the two groups(P>0.05).The number of positive cases in the experimental group was less than that in the control group,the difference was statistically significant(P<0.05).The serum PSA level in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).There were no significant differences in the number of rectal injury,urinary incontinence,urinary fistula and erectile dysfunction between the two groups(P>0.05).Conclusion Laparoscopic radical prostatectomy combined with NHT in the treatment of T3N0M0 stage prostate cancer is safe and effective,which could significantly reduce the positive rate of surgical margin,and have no effect on the operation difficulty and postoperative complications,which is worthy of clinical promotion.
2021 Vol. 28 (25): 121-123转127 [Abstract] ( 55 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
124 Effect of different pneumoperitoneum pressures on central venous pressure in patients undergoing laparoscopic gastrectomy and application of non-monitoring function
YE Wei； CHEN Jin-hong；YAO Sheng-lai
Objective To investigate the effect of carbon dioxide(CO2)artificial pneumoperitoneum with different pneumoperitoneum pressure on central venous pressure in patients undergoing laparoscopic partial gastrectomy.Methods A total of 40 patients with gastric tumors undergoing selective laparoscopic partial gastrectomy under general anesthesia in Huaiyin Hospital of Huai′an City,Jiangsu Province from May 2019 to December 2020 were selected as the study subjects.According to the random number table method,they were divided into group A and group B,with 20 patients in each group.The pneumoperitoneum pressure was set at 10 mmHg in group A and 15 mmHg in group B.The mean arterial pressure(MAP),heart rate(HR),oxygen saturation(SpO2),central venous pressure(CVP),mean airway pressure(Pmean),end-tidal pressure of carbon dioxide(PETCO2)and arterial partial pressure of carbon dioxide(PaCO2)before pneumoperitoneum(T0),30 min after pneumoperitoneum(T1),60 min after pneumoperitoneum(T2)and 10 min after pneumoperitoneum termination(T3)were compared between the two groups.Results There were no statistically significant differences in MAP,HR and SpO2 between the two groups at different time points(P>0.05).CVP,Pmean,PaCO2 and PETCO2 at T1 and T2 were higher than those at T0,and the differences were statistically significant(P<0.05).CVP,Pmean,PaCO2 and PETCO2 in group B at T1 and T2 were higher than those in group A,and the differences were statistically significant(P<0.05).Conclusion The effect of different pneumoperitoneal pressures on CVP differ,CVP increasing with high pressures.Surgery that requires a controlled low CVP,with an appropriate lower pneumoperitoneum pressure,is beneficial in lowering the CVP,at which point the CVP is no longer used as a monitor of circulatory function but rather as an adjunct to assist in lowering the CVP.
2021 Vol. 28 (25): 124-127 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
128 Effect of different doses of Oxycodone in the treatment of traction reaction during the second cesarean section
QIAN Xia-li ；CHEN Ya-jie
Objective To evaluate the effect of different doses of Oxycodone in the treatment of traction reaction during second cesarean section.Methods One hundred and twenty multiparas who underwent second cesarean section in Nanjing Maternity Child Health Care Hospital from October 2019 to December 2020 were selected as the research objects.According to the random number table method,they were divided into O1,O2,O3 and C groups,with 30 cases in each group.After the fetus was delivered,group O1,O2,and O3 were given Oxycodone Hydrochloride Injection 0.08,0.10,0.12 mg/kg,respectively.Group C was given the same dose of normal saline.The mean arterial pressure(MAP),heart rate(HR),saturation of pulse oximetry(SpO2)in the entering the room(T0),before administration(T1),10 min after administration(T2),when exploring the abdominal cavity(T3),and after operation(T4),Ramsay scores at T1,T2,T3 and T4 were compared among the three groups.Results The grading of the pull reaction in groups O2 and O3 were lower than that of the group C,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the grading of traction response between group O1 and group C(P>0.05).There were no statistically significant differences in MAP and HR at T0,T1,T2,T3 and T4 among group O1,O2,O3 and C(P>0.05).The SpO2 level of group O3 was lower than that of group O1,O2 and C at T2,T3 and T4,and the differences were statistically significant(P<0.05).At T1,there was no statistically significant difference in Ramsay scores among the group O1,O2,O3 and C(P>0.05).The Ramsay scores in groups O2 and O3 were higher than those in groups O1 and C at T2,T3 and T4,and the differences were statistically significant(P<0.05).Conclusion After the fetus was delivered,Oxycodone Hydrochloride Injection can provide good sedative and relieve the visceral traction response during the secondary cesarean section.Beyond that,0.10 mg/kg Oxycodone Hydrochloride Injection provides good sedative effect,fully inhibit the visceral traction response,and stabilize maternal vital signs.
2021 Vol. 28 (25): 128-131 [Abstract] ( 56 ) HTML (46 KB)  PDF  (0 KB)  ( 8 )
132 Comparison of the effect of Alfentanil and Sufentanil combined with Propofol intravenous continuous pumping in gastroscopy treatment
WANG Guo-qing
Objective To compare the anesthetic effect of Alfentanil or Sufentanil combined with Propofol in endoscopic therapy.Methods A total of 120 patients with gastric polyp treated with painless high-frequency electrocoagulation and electroresection under gastroscope in the Endoscope Center of People′s Hospital of Panjin City from May 2020 to November 2020 were selected as the research objects and divided into the control group and the experimental group by random number table method,with 60 cases in each group.In the control group,0.1 μg/kg of Sufentanil with 2 mg/kg of Propofol were injected intravenously and 6 mg/(kg·h)of Propofol was maintained.In the experimental group,6 μg/kg of Alfentanil with 2 mg/kg of Propofol were injected intravenously and 3 mg/(kg·h)of Propofol with 7 μg/(kg·h)of Alfentanil were maintained.In both groups,the gastroscope entered the mouth after the eyelash reflex disappeared.Pulse oxygen saturation(SpO2),heart rate(HR),mean arterial pressure(MAP),endoscopic treatment time,recovery time,muscle strength recovery time,total dose of propofol,pain numerical rating scale(NRS)score,incidence of nausea,vomiting,body motion,cough and respiratory depression were compared between the two groups at different time points.Results MAP and HR at T2 and T3 time points in experimental group were higher than those in control group,and SpO2 at T2 time point was higher than that in control group,and the differences were statistically significant(P<0.05).MAP,HR and SpO2 at T2,T3 and T4 were all lower than those at T1,and the differences were statistically significant(P<0.05).The recovery time and muscle strength recovery time of the experimental group were shorter than those of the control group,and the total dose of propofol was less than that of the control group,and the differences were statistically significant(P<0.05).The incidence of respiratory depression in experimental group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Synchronous intravenous pump injection of Alfentanil and Propofol in the gastroscope treatment can not only reduce the dosage of Propofol and shorten the recovery time of anesthesia,but also maintain circulation stability and reduce the occurrence of respiratory depression.
2021 Vol. 28 (25): 132-135 [Abstract] ( 52 ) HTML (40 KB)  PDF  (0 KB)  ( 7 )
136 Value of ultrasound elastography in differential diagnosis of TI-RADS4 thyroid nodules
WANG Fang-fang； SU Chang； WANG Ning； LIU Da-ming
Objective To evaluate the application value of ultrasound elastography in the differential diagnosis of benign and malignant TI-RADS4 thyroid nodules.Methods A total of 93 patients(108 thyroid TI-RADS4 nodules)who were performed thyroid ultrasound examination in the People′s Hospital of Liaoning Province from October 2017 to March 2020 were selected as the research subjects.The pathological diagnosis was taken as the golden standard.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of single application of TIRADS,ultrasonic elastography and combined application of the two for differential diagnosis of benign and malignant thyroid TI-RADS4 nodules were compared,and ROC curves were constructed to evaluate the value of each diagnostic method.Results The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of single application of ultrasonic elastography to diagnose thyroid nodule were 80.88%,75.00%,78.70%,84.61% and 69.77%,respectively.The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of TI-RADS diagnostic system were 77.94%,55.00%,74.65%,59.46% and 69.44%,respectively.The efficacy of TI-RADS classification combined with ultrasound elastography in diagnosis of thyroid nodules was higher than that of the two applications alone.Conclusion TI-RADS combined with ultrasound elastography has a high value in the diagnosis of benign and malignant thyroid TI-RADS4 nodules.
2021 Vol. 28 (25): 136-138转142 [Abstract] ( 48 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
139 Clinical application of S.T.O.N.E.imaging scoring system in ureteroscopic holmium laser lithotripsy for ureteral calculi
XIA Xi； WANG Su-gui； ZHOU Song-lin
Objective To explore the effect of S.T.O.N.E.image scoring system in predicting the stone clearance rate of ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi.Methods The clinical data of 98 patients with ureteral calculi who underwent ureteroscopic holmium laser lithotripsy treated in Dongtai People′s Hospital,Jiangsu Province from January 2017 to December 2019 were retrospectively analyzed.According to the postoperative calculus removal,they were divided into calculus removal group and calculus residual group.Both groups were scored by S.T.O.N.E.imaging scoring system.Surgical duration,postoperative hospital stay,surgical complications and S.T.O.N.E were compared between the two groups.And to analyze the predictive value of the S.T.O.N.E.imaging score system for stone clearance.Results The 98 patients were reexamined one week after surgery for stone residue,including 76 cases in the stone removal group and 22 cases in the stone residue group.The operation time and postoperative hospital stay of the stone removal group were shorter than those of the residual stone group,and the incidence of surgical complications was lower than that of the residual stone group,the differences were statistically significant(P<0.05).The differences in S.T.O.N.E.scores between the two groups were statistically significant(P<0.05).The total S.T.O.N.E score of the stone residue group was higher than that of the stone removal group,and the difference was statistically significant(P<0.05).The AUC of predicting calculus clearance by S.T.O.N.E.score was 0.952(95%CI:0.938-0.971, P<0.05),showing high accuracy.Conclusion S.T.O.N.E.imaging scoring system can effectively predict the clearance of ureteral calculi after ureteroscopic holmium laser lithotripsy,which is worthy of wide clinical application.
2021 Vol. 28 (25): 139-142 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
143 Application of CT combined with serological index in preoperative staging evaluation of female pelvic adjunct mass
ZHANG Yan
Objective To investigate the value of CT combined with serum carbohydrate protein 125(CA125)and human epididymal protein 4(HE4)in the preoperative staging of female pelvic adjunct mass.Methods A total of 92 female patients with pelvic accessory mass admitted to Jianli People′s Hospital in Hubei Province from September 2016 to September 2019 were selected as the research objects.All patients underwent CT examination,blood samples were collected to detect serum levels of CA125 and HE4,and pathological puncture diagnosis was performed to clarify the nature of the mass.The consistency between CT combined with serum CA125 and HE4 diagnosis and pathological diagnosis was analyzed to determine the sensitivity,specificity and accuracy of the combined diagnosis.With pathological staging as the gold standard,the evaluation value of CT combined with serum CA125 and HE4 for preoperative staging of female pelvic adjuncts was analyzed.Results Of the 92 patients,41(44.57%)were malignant and 51(55.43%)were benign.The levels of serum CA125 and HE4 in benign group were lower than those in malignant group,the differences were statistically significant(P<0.05).The consistency between CT diagnosis of pelvic adnexal malignant masses and pathological diagnosis was 0.732.The consistency of serum CA125 combined with HE4 in the diagnosis of pelvic adrenal malignancy was 0.594.The consistency of CT combined with serum CA125 and HE4 in the diagnosis of pelvic adnexal malignant masses was 0.801.With pathological puncture diagnosis as the gold standard,the total coincidence rate of CT combined with serum CA125 and HE4 in the evaluation of preoperative clinical staging of patients with malignant mass was 80.49%.The serum CA125 and HE4 of stage Ⅰpatients were lower than those of stage Ⅱand Ⅲ,and the serum CA125 and HE4 of stage Ⅱpatients were lower than that of stage Ⅲpatients,the differences were statistically significant(P<0.05).Conclusion CT combined with serum CA125 and HE4 has a high value in the identification of pelvic appendages including properties,and can be used in preoperative staging evaluation.
2021 Vol. 28 (25): 143-146 [Abstract] ( 47 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
147 The X-ray and MRI diagnosis of knee joint stress fracture in 25 junior middle school students
FU Zhen-hua； LUO Chun； CHEN Ting-ting； ZHOU Piao-hua
Objective To investigate the X-ray and MRI features of knee joint stress fracture,so as to improve the early diagnosis and treatment of the disease.Methods From April to June 2020,25 cases of knee joint stress fracture diagnosed by Changsha Hospital of Traditional Chinese Medicine were selected as the research object.The X-ray and MRI image characteristics of the patients were retrospectively analyzed,and the diagnostic ability of the two methods was compared.Results In 25 patients with stress fracture of knee joint,28 knees were examined by MRI,15 of them were examined by X-ray at the same time,X-ray examination was performed alone in 2 cases.The most serious injury site was the medial tibial condyle(17 cases,56.7%).12 tibial fracture lines were horizontal,5 femoral fracture lines were oblique,and 1 horizontal fracture line.The positive rate of MRI and the ability of displaying fracture line were higher than those of X-ray examination,the differences were statistically significant.Conclusion The medial metaphysis of tibia is easy to be damaged by stress fracture of knee joint.MRI is the first choice for early diagnosis and confirm diagnosis of stress fracture of knee joint.
2021 Vol. 28 (25): 147-150 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
151 The value of 64-slice spiral CT in preoperative diagnosis of colon cancer
ZUO Kai-rong；CHEN Li； ZHANG Yi；DAI Hong； LIU Yuan-bing
Objective To explore the clinical value of 64-slice spiral CT enhanced scanning and three-dimensional reconstruction in preoperative diagnosis of colon cancer.Methods The clinical data of 128 patients with colon cancer confirmed by surgical pathology or biopsy were analyzed retrospectively form January 2014 and January 2020 in the Second People′s Hospital of Jiangjin District in Chongqing City,and were compared with pathological results,the value of 64-slice spiral CT and three-dimensional reconstruction technique in preoperative diagnosis of colon cancer was evaluated.Results A total of 128 patients with colon cancer underwent 64-slice spiral CT enhanced scanning and three-dimensional reconstruction technique,it was found that 59 cases of colon masses,56 cases of colon thickening,49 cases of invasion around the colon,43 cases of lymph node metastasis,22 cases of liver metastasis,5 cases of peritoneal metastasis,6 cases of lung metastasis,1 case of ovarian metastasis and 5 cases of intestinal obstruction.The diagnostic accuracy and the misdiagnosis(missed diagnosis)rate of 64-slice spiral CT enhanced scanning and three-dimensional reconstruction technique were 86.62% and 13.62%,and there was no significant difference between the detection index and the surgical pathological results(P＞0.05).Conclusion 64-slice spiral CT enhanced scanning and three-dimensional reconstruction technique are accurate and reliable in preoperative diagnosis of colon cancer,and have important clinical application value.
2021 Vol. 28 (25): 151-154 [Abstract] ( 57 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
155 Analysis of characteristics of 60 cases of Risperidone-induced extrapyramidal side effect
ZHANG Ming-hui； ZHANG Hong-wei ；CHEN Jin-lan； HUANG Wen-can； XUE Xin-jie； ZHUANG Shu-li
Objective To analyze the clinical characteristics and medication characteristics of risperidone-induced extrapyramidal side effect(EPS).Methods The general data(sex,age,weight),medication methods(indications,dosage of medication,time of medication,combined medication)and clinical symptoms,treatment measures and outcome of 60 cases of Risperidone-induced EPS reported from Mental Hospital of Guangzhou Civil Affairs Bureau to the National Adverse Drug Reaction Monitoring Center from 2010 to 2019 were retrospectively analyzed.Results From the perspective of age distribution,among 60 adverse drug reaction(ADR)reports,the proportions of prime of life(41-50 years old),youth(21-30 years old)and middle-aged(31-40 years old)were relatively high,18%,17% and 13%,respectively.From the perspective of sex,the incidence of EPS caused by Risperidone was higher in female patients,which was 65.00%.According to the analysis of different types of tablets,the number of adverse reactions caused by oral tablets was the largest in 26 cases(43.33%),followed by orally disintegrating tablets of 24 cases(40.00%).From the dose analysis,when the daily dose of Risperidone was in the range of 4-6 mg,the risk of EPS was relatively high,and we did not observe the occurrence of EPS with a daily dose of 6 mg or more.From the perspective of the way of medication,there were more EPS in 39 cases(65.00%)when Risperidone was used alone.From the analysis of the time of occurrence,53.33% of the cases of EPS occurred within 1 month of medication,and 30.00% cases occurred within 10 days of medication.Among the 60 cases of EPS in this study,Parkinson′s syndrome was the main type(n=43,71.67%);increased muscle tone of the extremities(n=38,63.33%)was also common.After the occurrence of EPS,41.67% of the patients′ clinical symptoms subsided spontaneously as the treatment continued,11 patients improved after symptomatic treatment and dose reduction,and 7 patients needed to be replaced with other antipsychotic drugs.Conclusion The incidence of EPS caused by Risperidone is relatively high in middle-aged patients and mostly occurs within one month of medication.It is more likely to occur with a single medication.Symptomatic treatment and dose reduction can help alleviate the clinical symptoms of EPS.It is recommended to strengthen clinical monitoring of high-risk patients to avoid the occurrence of adverse reactions.
2021 Vol. 28 (25): 155-158 [Abstract] ( 56 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
159 Study on the therapeutic effect of four antituberculous regimens combined with the drug Moxifloxacin on tuberculous pleurisy
JIA Wen-cheng；LU Guan-nan
Objective To explore the therapeutic effect of the quadruple anti-tuberculosis program combined with the drug Moxifloxacin on tuberculous pleurisy.Methods A total of 48 cases of tuberculous pleurisy patients admitted to the Fourth Hospital of Chaoyang City from April 2017 to April 2018 were selected as the research objects,and were divided into the control group(24 cases)and the experimental group(24 cases)according to the random number table method.The control group was treated with a quadruple anti-tuberculosis regimen combined with conventional treatment,and the experimental group was treated with a quadruple anti-tuberculosis regimen combined with the drug Moxifloxacin.The immune function indicators of the two groups were compared,including the levels of T lymphocyte subsets CD8+,CD4+,CD4+/CD8+,and the levels of serum inflammatory factors including interferon-α(INF-α),interferon-γ(INF-γ),and interleukin 2(IL-2),interleukin 4(IL-4),interleukin 10(IL-10),clinical efficacy.Results The CD8+,CD4+,CD4+/CD8+,INF-γ,INF-α of the experimental group after treatment were higher than those of the control group,and the differences were statistically significant(P＜0.05).The IL-2,IL-4,IL-10 of the experimental group after treatment were lower than the control group,the differences were statistically significant(P<0.05).There were no significant difference in CD8+,CD4+,CD4+/CD8+,INF-γ,INF-α,IL-2,IL-4 and IL-10 between two groups before treatment(P>0.05).CD8+,CD4+,CD4+/CD8+,INF-γ,INF-α after treatment in the two groups were all higher than before treatment,and the differences were statistically significant(P<0.05).The IL-2,IL-4,and IL-10 levels of the two groups after treatment were lower than before treatment,and the differences were statistically significant(P<0.05).The total clinical effective rate(87.50%)of the experimental group was higher than that of the control group(54.16%),the difference was statistically significant(P<0.05).Conclusion The quadruple anti-tuberculosis regimen combined with the drug Moxifloxacin has a significant therapeutic effect in patients with tuberculous pleurisy,which can effectively inhibit the development of the disease and reduce adverse reactions.It is worthy of promotion and application.
2021 Vol. 28 (25): 159-162 [Abstract] ( 48 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
163 Effect of pulmonary surfactant combined with Budesonide in treatment of premature infants with neonatal respiratory distress syndrome
MENG Zhao-hui
Objective To investigate the clinical effect of pulmonary surfactant(PS)combined with Budesonide in the treatment of premature infants with neonatal respiratory distress syndrome(NRDS)and its effect on arterial blood gas status.Methods A total of 98 premature infants with severe NRDS admitted to Jinan Laiwu People′s Hospital from July 2019 to July 2020 were selected and divided into two groups according to random number table method,with 49 cases in each group.Both groups were given routine treatment,the control group was additionally treated with PS,and the observation group was additionally treated with Budesonide on the basis of PS treatment.The arterial blood gas status,ventilator related parameters,ventilation related indexes and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in arterial blood gas index and ventilator related parameters between the two groups(P>0.05).The partial blood oxygen pressure(PaO2)and oxygenation index(OI)of the two groups after treatment were higher than those before treatment,and the partial blood carbon dioxide pressure(PaCO2)of the two groups after treatment was lower than that before treatment,the PaO2 and OI of the observation group after treatment were(81.79±6.79)mmHg and(283.69±19.13)mmHg,which were higher than those of the control group,which were(76.68±6.34)and(264.41±17.76)mmHg,PaCO2 of the observation group after treatment was(40.52±4.58)mmHg,lower than that of the control group of(45.31±4.62)mmHg,and the differences were statistically significant(P<0.05).After treatment,the peak inspiratory pressure(PIP),inhaled oxygen concentration(FiO2)and respiratory rate(RR)of the two groups were all lower than those before treatment,and the PIP,FiO2 and RR of the observation group were(17.89±1.86)cmH2O,(29.68±4.05)% and(35.42±4.31)times/min after treatment,which were lower than those in the control group of(19.65±2.02)cmH2O,(33.71±4.27)%,(40.28±4.65)times/min,and the differences were statistically significant(P<0.05).The invasive ventilation time of the observation group was(3.25±0.42)d,weaning time of the observation group was(27.69±3.65)d,and hospitalization time of the observation group was(40.13±5.62)d,which were all shorter than those of the control group of(4.51±0.86),(31.14±3.85)and(46.85±5.79)d,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05),and no serious adverse reactions occurred in the two groups,which did not affect the treatment after symptomatic treatment.Conclusion PS combined with Budesonide can enhance the treatment effect of children with severe NRDS,improve the arterial blood gas index,correct the body′s hypoxia state,reduce the burden of respiratory support,and shorten the weaning time.It is safe and reliable.
2021 Vol. 28 (25): 163-166 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
167 Effect of probiotics in adjuvant treatment of non-alcoholic fatty liver disease
HU Xiao
Objective To investigate the efficacy of probiotics in adjuvant treatment of non-alcoholic fatty liver disease(NAFLD).Methods Seventy-two patients diagnosed with NAFLD in Fujian Provincial Hospital from January 2018 to December 2019 were selected as subjects.They were divided into observation group(n=36)and control group(n=36)by random number table method.The control group was treated with conventional symptomatic treatment,and the observation group was treated with conventional symptomatic treatment plus oral intestinal probiotics.Alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ -glutamyl transpeptidase(GGT),total bilirubin(TBil),total cholesterol(TC),triacylglycerol(TG),tumor necrosis factor-α(TNF-α)and body mass index(BMI)were compared between the two groups before and after treatment.Results After treatment,ALT,AST,GGT,TBil,TC,TG,TNF-α and BMI in the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,ALT,AST,GGT,TC and TG in observation group were lower than those in control group,the differences were statistically significant(P<0.05).There were no significant differences in TBil,TNF-α and BMI between the two groups(P>0.05).Conclusion Taking proper amount of probiotics has a certain positive effect on adjuvant treatment of NAFLD.
2021 Vol. 28 (25): 167-170 [Abstract] ( 61 ) HTML (36 KB)  PDF  (0 KB)  ( 8 )
171 Study on Sihuang Ointment in diabetic foot ulcer
WANG Chao-zhen； MENG Jie； ZHANG Tai-yang
Objective To explore the application effect of Sihuang Ointment in diabetic foot ulcer.Methods The clinical data of 80 patients with diabetic foot ulcers treated in Jiangxi Provincial Hospital of Integrated Traditional and Western Medicine from March 2019 to May 2020 were retrospectively analyzed.They were divided into the control group(40 cases)and the observation group(40 cases)according to different treatment methods.The control group was treated with Mecobalamin tablets orally,and the observation group was treated with Sihuang Ointment combined with Mecobalamin tablets.5 days was a course of treatment,and both groups were treated for 3 courses of treatment.The ulcer wound healing time,hospital stay,total clinical effective rate,the incidence of adverse reactions during treatment and the changes of ankle brachial index(ABI)and toe brachial index(TBI)before and after treatment were compared between the two groups.Results The wound healing time and hospital stay of patients in the observation group were significantly shorter than those in the control group,the differences were statistically significant(P＜0.05).The total clinical effective rate(95.00%)of the observation group after treatment was significantly higher than that of the control group(70.00%),the difference was statistically significant(P＜0.05).There was no statistically significant difference in ABI and TBI between the two groups before treatment(P＞0.05).The ABI and TBI of the two groups after treatment were significantly greater than those before treatment,and the ABI and TBI levels of the two groups after treatment of the observation group were significantly greater than those of the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion Sihuang Ointment can shorten the healing time and hospital stay of patients with diabetic foot ulcers,and significantly improve the total clinical effective rate of patients.It can effectively improve the level of ABI and TBI,and has high safety.
2021 Vol. 28 (25): 171-173 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
174 Effect of Traditional Chinese Medicine Massage,ginger acupoint application combined with acupoint massage on improving gastrointestinal discomfort in hemodialysis patients
CHEN Feng-xiang； CHEN Chang-lian； LIU Pei-pei ；LI Qing-ping ；JIE Li-si； YAN Zi-you
Objective To study the clinical significance of Traditional Chinese Medicine Massage,ginger acupoint application combined with acupoint massage in the treatment of gastrointestinal discomfort during hemodialysis.Methods A total of 60 patients with gastrointestinal discomfort during hemodialysis in the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January to December 2020 were selected and randomly divided into control group(30 cases)and observation group(30 cases).The control group was treated with ginger acupoint application combined with acupoint massage,and the observation group was treated with Traditional Chinese medicine massage on the basis of the control group.The therapeutic effect,motilin and substance P content before and after treatment,Traditional Chinese Medicine syndrome score(nausea and vomiting,vomiting,vomiting water,dizziness and anorexia)and quality of life(mental state,physical health,social role,material life)were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05 ).After treatment,the contents of motilin and substance P in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05 ).After treatment,the Traditional Chinese Medicine syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05 ).After treatment,the quality of life score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical effect of Traditional Chinese Medicine massage,ginger acupoint application combined with acupoint massage in patients with gastrointestinal discomfort during hemodialysis is significant,which can effectively alleviate gastrointestinal discomfort,increase gastric motility,reduce Traditional Chinese Medicine syndromes and improve quality of life.
2021 Vol. 28 (25): 174-177 [Abstract] ( 80 ) HTML (38 KB)  PDF  (0 KB)  ( 5 )
178 Effect analysis of self-made traditional Chinese medicine decoction in the treatment of children with hyperactivity of liver and wind -induced Tourette syndrome
AI Tian-mei； WU Sa
Objective To explore the effect of self-made traditional Chinese medicine decoction in the treatment of children with hyperactivity of liver and wind-induced Tourette syndrome.Methods A total of 60 cases of children with hyperactivity of liver and wind-induced Tourette syndrome treated in Yingtan Hospital of traditional Chinese medicine from January 2020 to February 2021 were selected as the research objects.According to the random number table method,they was divided into the experimental group and the control group,with 30 cases in each group.The experimental group was treated with self-made traditional Chinese medicine decoction,and the control group was treated with conventional western medicine.The therapeutic effects of the two groups were compared.Results The total clinical effective rate in the experimental group(96.66%)was higher than that in the control group(70.00%),and the difference was statistically significant(P＜0.05).The total incidence of skin itching,rash and digestive system adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The traditional Chinese medicine syndrome score of the experimental group was lower than that of the control group,with statistically significant difference(P＜0.05).Conclusion The self-made decoction of Traditional Chinese medicine has a good effect on the children with with hyperactivity of liver and wind-induced Tourette syndrome,which can effectively improve the clinical symptoms and promote the rehabilitation of the children.
2021 Vol. 28 (25): 178-180 [Abstract] ( 54 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
181 Effect of wax therapy combined with acupuncture on pain symptoms and functional rehabilitation of patients with lumbar disc herniation
CHEN Hui-juan ；ZONG Ying ；ZHAN Li-jun
Objective To investigate the intervention effect of wax therapy combined with acupuncture on patients with lumbar disc herniation(LDH).Methods Eighty patients with LDH who were treated in Hongdu Hospital of Traditional Chinese Medicine from April 2018 to May 2020 were selected as the research objects and divided into the control group and the observation group by random number table method,with 40 cases in each group.Patients in the control group were treated with acupuncture+routine nursing,and patients in the observation group were treated with wax therapy on the basis of the control group.Clinical efficacy,pain symptoms,lumbar function and hemorheology were compared between the two groups.Results The total clinical effective rate(97.50%)of the observation group was higher than that of the control group(72.50%),the visual analog scale(VAS)score after intervention was lower than that of the control group,the Japanese Orthopaedic Association scores(JOA)score was higher than that of the control group,the erythrocyte aggregation index,high and low shear blood viscosity were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The use of wax therapy combined with acupuncture in patients with LDH is beneficial to relieve the pain symptoms of patients,and plays an important role in improving the function of the patients′ lumbar spine,which is beneficial to improve the prognosis of patients.
2021 Vol. 28 (25): 181-183转194 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
184 Influence of Jiawei Chengqi Decoction on the coagulation function in patients with severe acute pancreatitis
XU Da-ming
Objective To explore the influence of Jiawei Chengqi Decoction on coagulation function in patients with severe acute pancreatitis.Methods From April 2018 to June 2020,96 patients with severe acute pancreatitis from the Second People′s Hospital of Jingdezhen City were selected,and they were divided into the experimental group and the control group by random number table method.The experimental group received conventional comprehensive treatment combined with Jiawei Chengqi Decoction treatment,the control group received conventional comprehensive treatment.The coagulation function(fibrinogen[FBG],activated partial thromboplastin time[APTT],prothrombin time[PT],platelet count[PLT],and thrombin time[TT])and biochemical indicators(serum calcium concentration,serum amylase)of the two groups were compared.Results After treatment,the level of FBG of the experimental group was lower than that of the control group,APTT,PT,TT of the experimental group were shorter than those of the control group,and the level of PLT indicators of the experimental group were higher than that of the control group,the differences were statistically significant(P＜0.05).After treatment,the serum calcium concentration of the experimental group was higher than that of the control group,and the blood amylase of the experimental group was lower than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion The treatment of Jiawei Chengqi Decoction in patients with severe acute pancreatitis can help patients restore blood coagulation function and improve the quality of life of patients,the clinical treatment effect is significant,and it is worthy of promotion and application.
2021 Vol. 28 (25): 184-186 [Abstract] ( 56 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
187 Clinical study of Bufei Huazhuo Decoction combined with acupoint application in treatment of chronic obstructive pulmonary disease in remission
HE Wei-jian； XIAO Wei； HU Xiao-hua； LIU Chong-shun； ZHANG Ping； HUANG Yu-huan
Objective To study the clinical effect of Bufei Huazhuo Decoction combined with acupoint application in the treatment of chronic obstructive pulmonary disease(COPD)in remission.Methods A total of 60 COPD patients who came to Fuzhou Hospital of Traditional Chinese Medicine from March 2020 to December 2020 were selected as the rasearch objects,and they were divided into the control group and the test group according to the random number table method,with 30 cases in each group.The patients in the control group were given Tiotropium Bromide Powder Inhalation,and the patients in the test group were given Bufei Huazhuo Decoction and acupoint application treatment.Patients in both groups were treated for 8 weeks.The symptom scores,lung function,dyspnea,quality of life,blood rheology indexes before and after treatment were compared between the two groups.Results The total effective rate of the test group(83.3%)was higher than that of the control group(73.3%),and the difference was statistically significant(P<0.05).There were no statistically significant differences in the levels of forced vital capacity(FVC),forced expiratory volume in the 1 second(FEV1)and FEV1 as a percentage of predicted value(FEV1%)between the two groups before treatment(P>0.05).The FVC,FEV1 and FEV1% levels of the two groups of patients after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The FVC,FEV1 and FEV1% of the test group after treatment were higher than that of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the scores of the modified British Medical Research Council respiratory questionnair(mMRC)and the chronic obstructive pulmonary disease assessment test(CAT)between the two groups before treatment(P>0.05).After treatment,the scores of mMRC and CAT of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the scores of mMRC and CAT of the test group were lower than those of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in high-cut whole blood viscosity,mid-cut whole blood viscosity,low-cut whole blood viscosity and plasma viscosity before treatment(P>0.05).After treatment,high-cut whole blood viscosity,mid-cut whole blood viscosity,low-cut whole blood viscosity and plasma viscosity of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,high-cut whole blood viscosity,mid-cut whole blood viscosity,low-cut whole blood viscosity and plasma viscosity of the test group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Bufei Huazhuo Decoction combined with acupoint application can alleviate the clinical symptoms and hemorheology of patients with COPD in remission,while reducing the number of acute attacks,thereby improving patients′ lung function and improving their quality of life.
2021 Vol. 28 (25): 187-190 [Abstract] ( 52 ) HTML (42 KB)  PDF  (0 KB)  ( 6 )
191 Application of Chaihu Shugan Powder combined with Sijunzi Decoction in patients with epigastric pain
QIN Peng； LI Chuang； SHEN Chen
Objective To explore the clinical effect of Chaihu Shugan Powder combined with Sijunzi Decoction in treatment of patients with epigastric pain.Methods Eighty-two patients with epigastric pain admitted to the 968th Hospital of the Joint Logistic Support Force of the People′s Liberation Army from July 2018 to June 2020 were selected as the research subjects.Random number table method was used to divide the patients into the control group and the experimental group,with 41 cases in each group.The control group was treated with conventional western medicine,and the experimental group was treated with Chaihu Shugan Powder and Sijunzi Decoction.The treatment effect,total incidence of adverse reactions,recurrence rate and traditional Chinese medicine syndrome score were compared between the two groups.Results The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in total incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of epigastric pain,epigastric distention,belching and acid reflux in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the scores of epigastric pain,epigastric distention,belching and acid reflux in the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion In the treatment of patients with epigastric pain,Chaihu Shugan Powder combined with Sijunzi Decoction has ideal therapeutic effect,can effectively improve the symptoms of patients and inhibit disease recurrence,and is safe and reliable,which worthy of reference.
2021 Vol. 28 (25): 191-194 [Abstract] ( 65 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
195 Clinical Effect of Yiqi Jianpi Huayu Decoction in sdjuvant treatment of advanced pancreatic cancer
CHEN Zhi-yong
Objective To explore the clinical effect of Yiqi Jianpi Huayu Decoction in adjuvant treatment of advanced pancreatic cancer.Methods A total of 120 patients with advanced pancreas who were admitted to the Department of Oncology,Ningde Hospital of Traditional Chinese Medicine from July 2018 to July 2020 were selected as the research objects.According to the random number table method,they were divided into a control group(60 cases)and an observation group(60 cases).The control group was treated with chemotherapy,and the observation group was treated with Chinese medicine decoction on the basis of the control group.The clinical effects,serum tumor marker levels,and the incidence of grade Ⅲ/Ⅳadverse reactions during the treatment period were compared between the two groups.Results There was no statistically significant difference in the objective response rate(ORR)and disease control rate(DCR)between the two groups(P>0.05).Before treatment,there was no significant difference in the serum carcino-embryonic antigen(CEA)and carbohydrate antigen 199(CA19-9)levels between the two groups(P>0.05).After treatment,the levels of CEA and CA19-9 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment the incidence of grade Ⅲ/Ⅳneutropenia,nausea and vomiting,and skin rash in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Yiqi Jianpi Huayu Decoction in the treatment of advanced pancreatic cancer is helpful to reduce the level of serum tumor markers and reduce serious adverse reactions.
2021 Vol. 28 (25): 195-197 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
198 Clinical effect of Ma′s warm moxibustion in the treatment of primary dysmenorrhea of cold coagulation and blood stasis type
WAN Ying； MENG Fan-ying
Objective To observe the clinical effect of Ma′s warm moxibustion in the treatment of primary dysmenorrhea of cold coagulation and blood stasis type.Methods A total of 40 patients with primary dysmenorrhea of cold coagulation and blood stasis type in Mentougou District Hospital of Traditional Chinese Medicine from January 2020 to November 2020 were selected as the research objects.The patients were divided into the control group and the observation group by random number table method,with 20 cases in each group.Patients in both groups began treatment one week before the onset of menstruation.Patients in the control group were treated with moxibustion box and moxibustion to baliao,and patients in the observation group were treated with Ma′s warm moxibustion,once a day,for 7 days consecutively for each menstrual cycle,for a total of three menstrual cycles.Visual analogue scale(VAS)score and treatment effect were compared between the two groups.Results Before treatment,there was no statistically significant difference in VAS score between the two groups(P>0.05).After 3 times of treatment,VAS scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the VAS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The effect of observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Ma′s warm moxibustion in the treatment of primary dysmenorrhea of cold coagulation and blood stasis type is reliable,the cure rate is higher,which is worthy of promotion.
2021 Vol. 28 (25): 198-200 [Abstract] ( 35 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
201 Investigation on the level of ergonomic load of pediatric nurses in a tertiary a specialized hospital in Jiangxi Province
LEI Jia-fang； LIU Xiao-shu； SUN Wen-jie； ZHU Yu-feng； HUANG Lu； CHEN Xiao-ying
Objective To investigate the ergonomic workload of pediatric nurses and analyze its characteristics.Methods A total of 163 pediatric nurses in Jiangxi Children′s Hospital from March to June 2020 were selected by convenience sampling method.Behavior observation and self-assessment survey were conducted using the comprehensive quick ergonomic check(CQEC).Results The work load score of pediatric nurses in the workplace was(178.88±27.98),at a higher level.The body load of pediatric nurses was different in different parts of the body.The body load of pediatric nurses was the largest in the neck(92.24%),followed by the wrist(80.37%),shoulder and arm(48.47%),lower limbs(33.12%)and back(28.22%).Multiple linear regression analysis showed that duty class and working years were independent factors of labor load level（P＜0.05）.Conclusion Pediatric nurses were highly loaded in positions as a result of various factors.Nursing managers should take intervention measures for the occupational health and safety of pediatric nurses.
2021 Vol. 28 (25): 201-204 [Abstract] ( 32 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
205 Analysis on the current situation and influencing factors of rehabilitation demand of elderly hypertension patients in Nanchang Nursing home
LI Min；DENG Shu-hong； XU Fang
Objective To explore the current situation of rehabilitation demand of elderly hypertensive patients in nursing homes in Nanchang city,and analyze the relevant factors that affect the rehabilitation needs.Methods A total of 146 elderly patients with hypertension admitted to the Fourth Affiliated Hospital of Nanchang University from August to December 2019 were selected as the research subjects.The general data questionnaire and the hypertension rehabilitation demand scale were used to investigate the elderly patients with hypertension who met the inclusion criteria.Multiple linear regression was used to analyze the factors influencing the rehabilitation needs of elderly patients with hypertension.Results The total score of rehabilitation needs of elderly patients with hypertension was(146.22±21.57),which was in the lower level.Univariate analysis showed that the total scores of rehabilitation needs of patients with different ages,education level,course of disease,type of medication,hypertension grade,number of comorbidities and whether they had received training related to hypertension rehabilitation were statistically significant(P＜0.05).Multiple linear regression analysis showed that education level,type of medication,number of comorbidiments and whether or not they have received training related to hypertension rehabilitation are independent factors affecting the rehabilitation needs of elderly patients with hypertension(P＜0.05).Conclusion The rehabilitation needs of elderly hypertensive patients are generally low,and they are affected by many factors.Medical staff should integrate the actual situation of the individual and formulate targeted rehabilitation health education according to the actual needs of the patient to promote the effective recovery of the postoperative patient.
2021 Vol. 28 (25): 205-207转211 [Abstract] ( 48 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
208 The mediating role of social support in stress and sleep quality
WANG Qi； MOU Yan-li； QIU Ri-yang
Objective To explore the mediating role of social support in the relationship between stress and sleep quality to promote the sleep quality of medical staff through intermediary channels.Methods Questionnaires were collected from nursing staff in two branches of Shenzhen Kangning Hospital.A total of 179 participants were enrolled.The questionnaire was designed to understand the nursing staff′s level of social support,mental health and sleep quality.Results Among the 179 nursing staff surveyed in this study,38(21%)reported stress symptoms,57(32%)reported depression symptoms,61(34%)reported the anxiety symptoms.Pearson correlation analysis showed that subjective support was positively associated with objective support,support utilization,and sleep quality(P<0.01);subjective support was negatively associated with stress stress,anxiety,depression(P<0.01);objective support was positively associated with support utilization(P<0.01).Regression analysis results showed that stress,anxiety,and depression is a negative predictor of sleep quality.In the mediation analysis,the utilization of social support played partial mediation effect in the relationship between stress and sleep quality.The Bootstrap test displayed 95% confidence interval[-0.578,-0.012]without 0,and the mediation model was successfully established.Conclusion Stress is closely related to sleep quality.Among them,social support,especially the utilization of social support,plays a mediating role in sleep quality.
2021 Vol. 28 (25): 208-211 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
212 Analysis of a case of Bromadiolone poisoning in children with no medical history and literature review
WU Ze-lin ；WEI Feng-gui
Bromadiolone is a long-acting anticoagulant rodenticide,chronic and highly toxic.The incubation period of poisoning is long,the clinical manifestations are diverse and atypical,and the diagnosis is not difficult for patients with clear exposure history of Bromadiolone.However,some people who have been poisoned are concealing their medical history,especially children,who often omit or conceal their medical history,which may easily lead to missed diagnosis and misdiagnosis,thus delaying treatment and even endangering their lives.The clinical data,diagnosis and treatment of a child with bromadiolone poisoning missed for more than 1 month were retrospectively analyzed.It is suggested that for children with unexplained bleeding and abnormal coagulation function,it is best to improve the routine blood rodenticide examination.At the same time,literature review was carried out in order to attract clinical attention and reduce missed diagnosis and misdiagnosis.
2021 Vol. 28 (25): 212-214 [Abstract] ( 50 ) HTML (28 KB)  PDF  (0 KB)  ( 7 )
215 A case report of Kennedy's disease and literature review
LIU Jie； ZHAO Sen
Kennedy′s disease is a rare nervous system degenerative disease,clinical performance because of its lack of specificity,It′s easy to misdiagnose and miss diagnosis.The diagnosis and differentiation of Kennedy′s disease were discussed through the neuroelectrophysiological changes and clinical characteristics.Genetic testing is still the gold standard for the diagnosis of Kennedy′s disease,which should be differentiated from amyotrophic laternal sclerosis in the early diagnosis.At present,there is no effective treatment for Kennedy′s disease,so early diagnosis and prevention are particularly important.In order to improve clinicians′ understanding of Kennedy′s disease,this article reviewed the clinical data of a patient with Kennedy′s disease who visited Zhongshan Hospital Affiliated to Dalian University from 2014 to 2020,analyzed the neuroelectrophysiology,clinical manifestations,diagnosis and treatment process,combined with literature review,emphasized the early differential diagnosis of Kennedy′s disease.
2021 Vol. 28 (25): 215-217 [Abstract] ( 55 ) HTML (28 KB)  PDF  (0 KB)  ( 6 )
218 Intervention effect of extended nursing on compliance behavior and quality of life of patients with polycystic ovary syndrome
SUN Jin-jin； SUN Lin ；TAO Jing
Objective To explore the intervention effect of extended nursing on compliance behavior and life of patients with polycystic ovary syndrome(PCOS).Methods A total of 79 cases of PCOS patients treated in Dalian Maternal and Child Health Hospital from July 2019 to July 2020 were selected as the research objects and divided into the study group(n=40)and the control group(n=39)by drawing of lots.Patients in the control group were given routine hospital care and discharge education.The study group was given extended nursing intervention on the basis of nursing intervention.The compliance behaviors,such as medication,regular work and rest,scientific diet and exercise were compared between the two groups before and half a year after discharge.The quality of life of the two groups before and after the intervention was compared,and the nursing satisfaction of the two groups was investigated and counted.Results Between the two groups,there were no significant difference in the scores of compliance behaviors on the compliance,regular rest,scientific diet and exercise before intervention(P＞0.05).After 6 months of intervention,the scores of compliance behaviors on the compliance,regular rest,scientific diet and exercise in the control group were lower than those before discharge(P<0.05).There were no significant difference between the scores of compliance behaviors on the compliance,regular rest,scientific diet and exercise in the study group(P＞0.05).After 6 months of intervention,the scores of compliance behaviors on the compliance,regular rest,scientific diet and exercise in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Before discharge,there was no significant difference in the scores of quality of life between the two groups(P＞0.05).Six months after discharge,the scores of quality of life in the two groups were higher than those before discharge,and the scores of quality of life in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).The nursing total satisfaction of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion The implementation of extended nursing can urge PCOS patients to maintain good compliance behavior,and has a positive role in improving their quality of life and nursing satisfaction.
2021 Vol. 28 (25): 218-220转224 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
221 Application effect of the Internet+integrated medical care model in children discharged from hospital after pediatric surgical fracture
LIN Mei-fang； LI Heng
Objective To explore the application effect of the internet+integrated medical care model in children discharged from the hospital after pediatric surgical fractures.Methods Eighty children with fractures admitted to Pingxiang People′s Hospital from August 2018 to October 2020 were selected as the research subjects.They were divided into the conventional group(n=40)and the observation group(n=40)used computer-generated random number table method.The conventional group adopted the traditional nursing model,and the observation group used the internet+integrated medical care model.The pain scores,knowledge scores,complications and compliance of the two groups of patients were compared.Results There was no statistically significant difference in pain scores between the two nursing groups(P＞0.05).After nursing,the pain score of the observation group was lower than that of the conventional group,the follow-up score of the observation group was higher than that of the conventional group,and the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the conventional group,the total compliance of the observation group was higher than that of the conventional group,the differences were statistically significant(P<0.05).Conclusion The model based on the Internet+integrated medical care can alleviate the pain of children,reduce the risk of complications,and improve their compliance outside the hospital.
2021 Vol. 28 (25): 221-224 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
225 Application of patient participation model based on grounded theory in rehabilitation nursing of hip replacement
FAN Fen； XU Fang
Objective To explore the application value of patient participation model based on grounded theory in rehabilitation nursing of hip replacement.Methods Sixty-three patients underwent hip replacement in the Fourth Affiliated Hospital of Nanchang University from October 2017 to October 2019 were selected as research subjects,and were divided into the observation group(n=30)and the control group(n=33)by coin toss.The control group was given routine health education and rehabilitation training.The observation group was given the patient participation model based on grounded theory,the emotion and reaction of patients were taken as the theoretical basis to guide the postoperative rehabilitation nursing,and the rehabilitation nursing in line with the actual situation of patients was formulated and implemented.Harris hip function score,activities of daily living(ADL),rehabilitation training compliance and nursing satisfaction were compared between the two groups.Results Harris score,ADL score,rehabilitation training compliance and nursing satisfaction in the observation group were higher than those in the control group,with statistical differences(P<0.05).Conclusion The patient participation model based on grounded theory has a definite application effect in the rehabilitation nursing of hip replacement surgery,which is conducive to obtaining better rehabilitation effects and improving the life quality of patients.
2021 Vol. 28 (25): 225-228 [Abstract] ( 40 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
229 Clinical application of pagination type pressing bag for medical surgical wiring harness in the nursing process of operating room
ZHANG Lian-ying；CHEN Yu； SONG Li； ZHOU Zeng；LONG Jie
Objective To explore the clinical application of pagination type medical surgical wiring harness pressing bag in the nursing process of operating room.Methods The clinical data of 88 patients with surgical treatment in Ganzhou Maternal and Child Health Hospital from June to December 2020 were retrospectively analyzed.According to the different placement methods of suture bundles during surgical treatment,they were divided into the control group(44 cases)and the study group(44 cases).The control group was placed with ordinary medical cloth alone,and the study group was placed with pagination type medical surgical harness pressing bag.The operation time of threading needle and wire,the moisture retention time of wiring harness,the situation of suture confusion,knot and winding,and the satisfaction with the operation and scheme were compared between the two groups.Results The operation time of the study group was shorter than that of the control group,the moisture retention time of wiring harness of the study group was longer than the control group,the situation of suture confusion,knot and winding of the study group had fewer than that of the control group,the differences were statistically significant(P<0.05).The study group was more satisfied with the operation and the scheme than the control group,the difference was statistically significant(P<0.05).Conclusion In the process of nursing in the operating room,the application of pagination type medical surgical wire harness pressing bag to place suture wire harness can shorten the operation time of threading,wire harness moisturizing and operation time,solve the problems of suture confusion,knot and winding,and significantly improve the level of satisfaction.
2021 Vol. 28 (25): 229-231 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
232 Effect of animation health education based on empowerment theory on self-efficacy of patients with rib fracture rehabilitation
XU Xiao-li； HUANG Yan-qing； REN Hai-bo
Objective To explore the effect of empowering theory-based animation education on the self-efficacy of patients with rib fracture rehabilitation.Methods A total of 60 adult patients with rib fracture from June 2019 to July 2020 in Pingxiang Second People′s Hospital were selected and divided into the experimental group and the control group according to random number table method,30 cases in each group.The control group received conventional health education intervention,and the experimental group received four times of animation health education intervention according to the authorization theory at the time of admission,one week after admission,three weeks after admission and seven weeks after admission,the scores of self-efficacy,compliance of behavior habit and pulmonary complications were compared between the two groups.Results At the time of entry,there were no statistically significant difference between the two groups′ self-efficacy scores and behavioral compliance(P＞0.05).After 1,3,and 7 weeks,the self-efficacy score of the observation group was higher than that of the control group,the observation group′s behavioral habit compliance was higher than that of the control group,and the differences were statistically significant(P<0.05).The pulmonary complications of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Animated health education based on empowerment theory can improve the self-efficacy of patients recovering from rib fractures,improve their compliance with doctors,reduce complications,relieve negative emotions,and improve patient and family satisfaction.
2021 Vol. 28 (25): 232-235 [Abstract] ( 49 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
236 Application effect of acupoint massage combined with traditional Chinese medicine body differentiation and conditioning nursing in patients with hypertension
LIU Ying；LI Zheng
Objective To explore the application effect of acupoint massage combined with traditional Chinese medicine body differentiation and conditioning nursing in patients with hypertension.Methods A total of 130 hypertensive patients admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from September 2020 to January 2021 were selected as the research objects.The random number table was used to divide them into the observation group(65 cases)and the control group(65 cases).The control group used conventional treatment and traditional Chinese medicine body-differentiation and conditioning nursing methods,and the observation group used conventional treatment,traditional Chinese medicine body-differentiation and conditioning nursing methods and acupoint massage methods.The clinical efficacy of the two groups of patients after 3 months of nursing,before nursing and 3 months after nursing,the scores of traditional Chinese medicine syndromes such as pain,dizziness,irritability，insomnia,tinnitus,anxiety,depression,and quality of life negative emotions were compared.Results After 3 months of nursing,the total clinical effective rate of the observation group(90.77%)was higher than that of the control group(72.31%),and the difference was statistically significant(P<0.05).The two groups had headache,dizziness,irritability and irritability after 3 months of nursing,the scores of traditional Chinese medicine syndromes such as anger,insomnia,tinnitus,anxiety,depression,quality of life and negative emotion scores were lower than those before nursing,The observation group was lower than the control group,and the differences were statistically significant(P<0.05).Conclusion Acupoint massage combined with traditional Chinese medicine body differentiation and conditioning nursing can effectively relieve the clinical symptoms of patients with hypertension,improve emotions,improve compliance and clinical efficacy,and control the progression of the disease.
2021 Vol. 28 (25): 236-239转243 [Abstract] ( 48 ) HTML (40 KB)  PDF  (0 KB)  ( 8 )
240 Influence of staged nursing on patients with endometrial cancer
TIAN Xiao-yu；ZHANG Ying-yan；JIANG Xue-mei
Objective To discuss the influence of staged nursing on patients with endometrial cancer.Methods A total of 80 endometrial cancer patients admitted to the Northern Theater General Hospital from December 2019 to December 20 were selected as the research subjects.According to the random paper method,they were divided into the control group and the observation group,40 cases in each group.Patients in the control group adopted routine nursing measures,and in the observation group,staged nursing used.The score of uncertainty,the score of quality of life,the score of depression,and the score of anxiety of the two groups of patients were compared before and after the intervention.Results There were no significant difference in the uncertainty score,the quality of life score，the depression score,or the anxiety score between the two groups of patients before the intervention(P＞0.05).After the intervention,the two groups of patients′ uncertainty scores and quality of life scores were higher than those of the before the intervention,depression scores and anxiety scores were lower than those of the before intervention,the scores of uncertainty and quality of life of the observation group were higher than those of the control group and the depression score and anxiety score were lower than those of the control group,the compliance of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion The application of staged nursing on patients with endometrial cancer can improve the patient′s uncertainty in disease,quality of life,psychological mood,and increase compliance.
2021 Vol. 28 (25): 240-243 [Abstract] ( 46 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
244 Application effect of positive psychology theory in rehabilitation nursing of schizophrenia
ZHU Yan-ling； LIAO Xiao-hua； ZHANG Xian-qiang；LIU Shu-xian；HUANG Cai-ming；DU Shu-hua； ZHU Hai-bin
Objective To explore the application effect of positive psychology theory in rehabilitation nursing of schizophrenia.Methods A total of 96 patients with schizophrenia in Mental Hospital of Guangzhou Civil Affairs Burea from May 2019 to April 2020 were selected as subjects.The patients were divided into the control group and the experimental group according to the random number table method,48 patients in each group.The control group received routine nursing.The experimental group received routine nursing combined with positive psychological theory intervention.The scores of happiness enterprising initiative questionnaire(HEIQ)scale and self -rated health measurement scale(SRHMS)were observed and compared between the two groups at admission and 1,2,3 months after intervention.Results After 1,2,and 3 months of intervention,the HEIQ scores of patients of the two groups were gradually increased and higher than the HEIQ scores at admission,the differences within the group were statistically significant(P＜0.05).After 1,2,and 3 months of intervention,the scores of HEIQ scale in the experimental group were higher than those in the control group at the same time period,and the difference was statistically significant(P＜0.05).After 1,2,and 3 months of intervention,the SRHMS scale scores of patients of the two groups were gradually increased and higher than the SRHMS scale scores at admission,the differences within the group were statistically significant(P＜0.05).After 1,2,and 3 months of intervention,the scores of SRHMS scale in the experimental group were higher than those in the control group at the same time,the differences were statistically significant(P＜0.05).Conclusion The application of positive psychology theory to patients with schizophrenia can improve the health status of patients while improving their happiness and enterprising,which is worthy of clinical promotion.
2021 Vol. 28 (25): 244-246 [Abstract] ( 41 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
247 Application effect of in-hospital + early-discharge home rehabilitation model in patients with acute coronary syndrome
SHI Ying
Objective To explore the application effect of in-hospital+early-discharge home rehabilitation model in patients with acute coronary syndrome.Methods From June 2019 to June 2020,60 patients with acute coronary syndrome admitted to the First People′s Hospital of Jingdezhen City in Jiangxi Province were selected as the research subjects.According to the random number table method,they were divided into the control group(30 cases)and the test group(30 cases).The control group received routine secondary prevention nursing of coronary heart disease,and the test group received in-hospital + early-discharge home rehabilitation model nursing.Both groups received nursing for 3 months.The clinical observation indexes and 6 min walking distance of the two groups before and after nursing were compared.Results There were no significant difference in the total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),body mass index(BMI),systolic blood pressure,diastolic blood pressure,smoking cessation rate,6-min walking distance in the first between the two groups before nursing(all P＞0.05).The levels of TC and LDL-C of the two groups of patients after nursing were lower than those before nursing,and the levels of TC and LDL-C of the test group after nursing were lower than those the control group,the differences were statistically significant(P＜0.05).The smoking cessation rate of patients in the test group(60.00%)was higher than that of the control group(30.00%),and the difference was statistically significant(P＜0.05).The 6-min walking distance in the two groups after nursing were greater than those before nursing,and the 6-min walking distance in the experimental group after nursing was greater than that in the control group,the differences were statistically significant(all P＜0.05).While there were no significant difference in the levels of the BMI,systolic blood pressure,and diastolic blood pressure between the two groups after nursing(all P＞0.05).Conclusion In hospital + early-discharge home rehabilitation mode can effectively improve the levels of TC and LDLC in patients with acute coronary syndrome,increase the 6-minute walking distance,and improve their daily physical activity ability,the application effect is better.
2021 Vol. 28 (25): 247-249 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
250 Analysis of continuing nursing needs and influencing factors for patients with moderate to severe psoriasis
DENG Wen-ya；DONG Le； GUI Jun-fang； LIU Yan-ru2； WANG Rong
Objective To explore the current situation and influencing factors of continuing nursing care demands of patients with moderate to severe psoriasis.Methods A total of 477 patients diagnosed with moderate to severe psoriasis in Shanghai Skin Disease Hospital from December 2020 to February 2021 were selected by convenience sampling method,and the questionnaire survey was conducted to analyze the demand for continuing care and its influencing factors.Results There were 402 patients(85.35%)with continuing nursing care demands,the most demanding items were medication methods and precautions.Network communication was the best form of service.Hospital nurses were the most popular service staffs.Univariate analysis showed that different treatment methods,education level,family per capita monthly income,medical payment forms,treatment schemes and complications were associated with continuing care needs of patients with moderate to severe psoriasis(P<0.05). Logistic regression analysis showed that traditional treatment plan(β=1.005, OR=2.733,95%CI=1.590-4.700)and complications(β=2.093, OR=8.111,95%CI=0.819-3.325)were the independent risk factors affecting the continuing care needs of patients with moderate to severe psoriasis(P<0.05).The payment form of medical insurance for urban workers was a protective factor(β=-0.705, OR=0.494,95%CI=0.258-0.946).Conclusion There are more demands for continuing nursing care in patients with moderate to severe psoriasis,suggesting that the continuing care scheme should be based on the patients′ continuing care demands,and build an individualized and diversified continuing care mode.

 
2021 Vol. 28 (25): 250-254 [Abstract] ( 48 ) HTML (40 KB)  PDF  (0 KB)  ( 8 )
255 Application of music intervention combined with comfort pacifier in neonatal puncture
QIU Yu-zhen； ZHENG Li-ting； TANG Li-zhen
Objective To study the application effect of music intervention combined with pacifier in neonatal puncture.Methods Sixty newborns who were born in Shekou People′s Hospital,Nanshan District,Shenzhen from December 2018 to November 2019 who needed puncture were selected as the research objects.The random number table method was used to divide them into the experimental group and the control group,30 cases in each group.The control group of newborns only routine care was used for the puncture operation,and the newborns in the experimental group were combined with music intervention and comfort pacifiers,the pain degree score,heart rate,respiration,systolic blood pressure,diastolic blood pressure,diastolic blood pressure(SpO2),quality of life score,and adverse reactions between the two groups were compared.Results Before intervention,there was no statistically significant difference in neonatal pain scores between the two groups(P＞0.05).After intervention,the neonatal pain score in the experimental group was lower than that in the control group,with statistical difference(P<0.05).Before nursing,the heart rate,respiration,systolic blood pressure,SpO2 between the two groups were not statistically significant(P＞0.05).After nursing,the heart rate,respiration,systolic blood pressure,diastolic blood pressure and SpO2 of the experimental group were lower than those of the control group,with statistical differences(P<0.05).Before intervention,there was no significant difference in quality of life scores between the two groups(P＞0.05).After nursing,the quality of life score of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The nursing intervention based on music intervention combined with pacifier can significantly relieve the pain of puncture neonates,improve the physical stress status during puncture,and promote the improvement of the quality of life of infants,and it is safe and reliable.
2021 Vol. 28 (25): 255-258 [Abstract] ( 39 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
259 Influence of comprehensive nursing intervention and the application of maternal and child health information management platform on the outcome of re-pregnancy in scarred uterus
LI Feng-rong； HUANG Xiao-yan； HE Xing
Objective To explore the influence of comprehensive nursing intervention and the application of maternal and child health information management platform on the outcome of re-pregnancy and delivery in scarred uterus.Methods A total of 200 re-pregnant women with scarred uterus who were admitted to Yangjiang Maternal and Child Health Hospital from March to November 2020 were selected as the research subjects.According to the random number table method,they were divided into the control group(n=100)and the observation group(n=100).In the control group,routine prenatal clinics and health education were used,and in the observation group,scarred uterus comprehensive nursing intervention and maternal and child health information platform management were adopted.The delivery methods,the total labor of vaginal delivery,the amount of bleeding during delivery and 24 h after delivery,the occurrence of postpartum complications,the weight of the newborn,and the Apgar scores of the newborn at 1 and 5 min of the two groups were compared.Results The observation group had more vaginal delivery cases than the control group,and the total labor was shorter than that of the control group,the amount of bleeding during delivery and 24 h after delivery were lower than those in the control group,with statistical differences(P<0.05).The rate of postpartum complications occurred in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The weight of newborns in the observation group was lower than that in the control group,and the Apgar score at 1 min was lower than that in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in 5 min Apgar score between the groups(P＞0.05).Conclusion The application of comprehensive nursing intervention and maternal and child health information management platform to pregnant women with scarred uterus can improve the outcome of childbirth.
2021 Vol. 28 (25): 259-261转265 [Abstract] ( 52 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
262 Influence of mental awareness intervention program on psychosocial adaptation of patients with breast cancer with radiotherapy
WEI You-fang； SU Jiang-hua； HE Qiu-na；n KONG Mei-lan； ZHAI Xiao-juan
Objective To analyze the influence of mental awareness intervention program on the psychosocial adaptation of breast cancer patients with radiotherapy.Methods Eighty-eight breast cancer patients who accepted radiotherapy and were admitted to Xiaolan Hospital of Southern Medical University from January to December 2019 were selected as the research subjects.They were divided into the control group(n=44)and the observation group(n=44)by random number table method.Patients in the control group received routine nursing care,and in the observation group,they received mental awareness intervention on the basis of routine nursing.The scores of psychosocial adaptation and mental awareness level between the two groups were compared before and after the intervention.Results There were no significant difference in score of anxiety/depression,self-esteem and self-acceptance,attitude,sense of belonging,selfcontrol or self-efficacy between the two groups before intervention(P＞0.05).The scores of anxiety/depression,self-esteem and self-acceptance,attitude,sense of belonging,self-control and self-efficacy between the two groups after intervention were higher than those in the same group before the intervention,the observation group had higher scores of anxiety/depression,self-esteem and self-acceptance,attitude,sense of belonging,self-control and self-efficacy after the intervention than the control group,the differences were statistically significant(P<0.05).There was no significant difference between the observation group and the control group in the scores of mental awareness before the intervention(P＞0.05).The scores of the mental awareness of the two groups after intervention were higher than those in the same group before the intervention,the score of mental awareness level after intervention in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The mental awareness intervention program can improve the psychosocial adaptation of patients with breast cancer for radiotherapy in clinic,and it is worthy of reference and promotion in clinical practice.
2021 Vol. 28 (25): 262-265 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
266 Applications of mobile multimedia memory therapy in alleviating behavioral and psychological symptoms of patients with Alzheimer disease
LI Yan-ling；WANG Xiu；SHAN Shu-zhen； WANG Wei
Objective To investigate the role of mobile multimedia memory therapy in alleviating Alzheimer′s Disease(AD).Methods A total of 100 AD patients admitted to Xinhua Hospital Affiliated to Dalian University from April 2016 to April 2019 were selected as the research objects,and were divided into the experimental group and the control group by drawing lots,50 cesas in each group.The control group was given memantine tablets 10 mg/time,2 times/d,for 16 weeks,and the experimental group was given multimedia memory therapy on the basis of the control group.The minimental stateamination(MMSE)was used to measure cognitive function.The neuropsychiatric inventory(NPI)was used to measure the behavioral and psychological symptoms of dementia(BPSD).The evaluation results of MMSE and NPI scales were compared between the two groups before treatment and at the end of the 16th week.Results The MMSE scores of the experimental group after 16 weeks of treatment were higher than before treatment,the MMSE scores of the experimental group was higher than that of the control group,the differences were statistically significant(P<0.05).After 16 weeks of treatment,the indicators of agitation/aggression,depression/dysthymia,and anxiety in the experimental group were lower than those before treatment,the differences were statistically significant(P<0.05).Conclusions Mobile multimedia memory therapy could be used for alleviating AD and improving mental and behavioral symptoms.This therapy could be recommended for clinical application.
2021 Vol. 28 (25): 266-269 [Abstract] ( 36 ) HTML (36 KB)  PDF  (0 KB)  ( 8 )
270 Effect of humanistic care on the clinical symptoms of patients with confusion after artificial hip replacement
LIU Dan； YANG Wan-xiang
Objective To explore the effect of humanistic care on the clinical symptoms of patients with confusion after artificial hip replacement(THA).Methods A total of 100 patients with delirium after THA who were admitted to the First Affiliated Hospital of Fujian Medical University from January 2018 to October 2020 were selected as the research subjects.According to the random number table method,they were divided into the experimental group(50 cases)and the control group(50 cases).The control group was treated with conventional nursing and the experimental group was treated with humanistic care nursing.The confusion assessment method(CAM)score,duration of confusion,and hospital stay between the two groups were compared.Results The 24,48,72 h,and pre-discharge CAM scores of the experimental group were lower than those of the control group after surgery,the CAM scores of the experimental group at 48,72 h,before discharge,and the control group at 72 h and before discharge were lower than 24 h after operation,the differences were statistically significant(P<0.05).The duration of confusion and hospital stay in the experimental group were shorter than those in the control group,the nursing satisfaction score was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion Patients with confusion after THA receiving humanistic care intervention can greatly control the degree of postoperative confusion,shorten the duration of confusion and hospital stay,and the patients′ satisfaction is high,which is of great application significance.
2021 Vol. 28 (25): 270-272转276 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
273 Application effect of new dressings in patients with open infected wounds in orthopedic surgery
PENG Yin-ling； HUANG Xue-ping； PENG Xi-ling

Objective To explore the application effect of new dressing care for open infected wounds of orthopedic surgery patients in preventing postoperative infections.Methods A total of 90 orthopedic surgery patients admitted from January to December 2019 in Huadu District People′s Hospital of Guangzhou were selected as the research subjects.They were divided into the control group(45 cases)and the study group(45 cases)according to the random mumber table method.The control group was treated with conventional gauze dressing.The study group was provided with new dressings to change dressings.The hospitalization time,the number of dressing changes,the healing time of orthopedic open infection wounds,the incidence of complications and the evaluation of patients′ satisfaction with nursing care were observed and compared between the two groups.Results The hospitalization time and healing time of orthopedic open infection wounds in the study group were shorter than those in the control group,the number of dressing changes in the study group was less than that in the control group,the differences were statistically significant(P<0.05).The incidence of complications was lower than that in the control,.the total satisfaction of nursing care of the study group was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion The implementation of new dressing care for orthopedic open infection wounds of orthopedic surgery patients obtains significant clinical effects.It can shorten the wound healing time,reduce the incidence of complications and improve patients′ satisfaction with nursing work.It is worthy of extensive promotion in the clinic.
2021 Vol. 28 (25): 273-276 [Abstract] ( 52 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
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